Ohtsuka Takashi 大塚崇

… Alternative Names

OHTSUKA Takashi 大塚崇

大塚崇オオツカタカシ

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Researcher Number	40306717
Other IDs	https://orcid.org/0000-0002-8039-9159
Affiliation (Current)	2023: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 東京慈恵会医科大学, 医学部, 教授 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 准教授 2015: 慶應義塾大学, 医学部, 准教授 2011 – 2014: 慶應義塾大学, 医学部, 講師 2002: 慶應大, 医学部, 助手 2000 – 2001: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Respiratory surgery / Thoracic surgery / Basic Section 55040:Respiratory surgery-related / Thoracic surgery Except Principal Investigator Respiratory surgery / Basic Section 49030:Experimental pathology-related / Basic Section 55010:General surgery and pediatric surgery-related / Experimental pathology / General surgery / Thoracic surgery
Keywords	Principal Investigator 肺移植 / 拒絶反応 / 急性肺障害 / 一酸化炭素 / 間葉系幹細胞 / 移植 / 制御性Ｔ細胞 / Ｔ細胞 / 肺移植拒絶反応 / マトリックスメタロプロテアーゼ … More / メタロプロテアーゼ / マイクロソフィア / 血管新生 / 人工酸素運搬体 / 血管新生抑制物質 … More Except Principal Investigator プロテアーゼ / 人工酸素運搬体 / 肺損傷 / 空間的発現解析 / 腫瘍免疫 / がん微小環境 / 心臓移植 / 虚血再灌流傷害 / 人工ガス運搬体 / 心移植 / がん関連線維芽細胞 / エピゲノム / 網羅的解析 / 腫瘍間質 / 線維芽細胞 / がん / radiation / chemotherapy / artificial oxygen carrier / Ly-80 / tumor / rat / 補助科学療法 / 動脈内注入 / 腫瘍循環 / 腫瘍内酸素分圧 / LK-80 / 放射線療法 / 抗癌剤 / LY-80 / 腫瘍 / ラット / オートファジー / ビスフォスフォネート / ゾレドロン酸 / 悪性胸膜中皮腫 / ヘモグロビン小胞体 / 呼吸不全 / 肺切除 / 出血性ショック / 外科手術 / 人工赤血球 / Eセレクチン / E-selectin / 肺線維症 / 可溶性分画 / 動物モデル / 好中球 / セレクチン / 急性肺損傷 / 肺移植 Less

個細胞空間的degradome解析に基づくプロテアーゼを介したがん免疫制御の解明
- Principal Investigator
  
  下田将之
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Jikei University School of Medicine
Amelioration of acute lung injury by lung mesenchymal stem cell and carbon monoxide.Principal Investigator
- Principal Investigator
  
  大塚崇
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Jikei University School of Medicine
Establishment of a new method using carbon monoxide aiming at long-term preservation of donor heart for heart transplantation
- Principal Investigator
  
  Kimura Naritaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Keio University
Amelioration of rejection after lung transplant by newly developed gas carrier.Principal Investigator
- Principal Investigator
  
  Ohtsuka Takashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Jikei University School of Medicine
  Keio University
Analysis of cancer-associated fibroblasts from the perspective of proteinases and epigenetics
- Principal Investigator
  
  SHIMODA MASAYUKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.Principal Investigator
- Principal Investigator
  
  Ohtsuka Takashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Keio University
The cytostatic effects of zoledronic acid on ACC-MESO-1 cells
- Principal Investigator
  
  Asakura Keisuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Keio University
Effect of oxygen infusion with hemoglobin vesicles on respiratory insufficiency
- Principal Investigator
  
  KOHNO Mitsutomo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Tokai University
  Keio University
Involvement of E-selectin in reimplantation lung injury
- Principal Investigator
  
  GOTO Taichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
The effect of Carbon monoxide and Adenosine receptor in bronchiolitis obliterans in mice trachea transplantation model.Principal Investigator
- Principal Investigator
  
  OHTSUKA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
肺癌の浸潤、転移におけるプロテアーゼの関与の研究Principal Investigator
- Principal Investigator
  
  大塚崇
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KEIO UNIVERSITY
人工酸素運搬体と血管新生抑制物質の併用による腫瘍抑制効果の測定Principal Investigator
- Principal Investigator
  
  大塚崇
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University

All 2020 2019 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Simultaneous 2D and 3D simulation of thoracoscopic sleeve lobectomy: a quick understanding pitfalls2020
- Author(s)
  Nakada Takeo、Noda Yuki、Kato Daiki、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
- Journal Title
  
  The Annals of Thoracic Surgery
  
  Volume: 印刷中 Issue: 5 Pages: e383-e385
- DOI
  10.1016/j.athoracsur.2019.11.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08581
[Journal Article] Infiltration of tumor‐associated macrophages is involved in tumor programmed death‐ligand 1 expression in early lung adenocarcinoma2020
- Author(s)
  Shima Toshiyuki、Shimoda Masayuki、Shigenobu Takao、Ohtsuka Takashi、Nishimura Tomoyasu、Emoto Katsura、Hayashi Yuichiro、Iwasaki Tatsuro、Abe Takayuki、Asamura Hisao、Kanai Yae
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 727-738
- DOI
  10.1111/cas.14272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08581, KAKENHI-PROJECT-19K07422, KAKENHI-PROJECT-17K10800
[Journal Article] Risk factors and cancer recurrence associated with postoperative complications after thoracoscopic lobectomy for clinical stage I non‐small cell lung cancer2019
- Author(s)
  Nakada Takeo、Noda Yuki、Kato Daiki、Shibasaki Takamasa、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Hirano Jun、Odaka Makoto、Ohtsuka Takashi
- Journal Title
  
  Thoracic Cancer
  
  Volume: 10 Issue: 10 Pages: 1945-1952
- DOI
  10.1111/1759-7714.13173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08581
[Journal Article] Recovery of pulmonary function after lung wedge resection2019
- Author(s)
  Mori Shohei、Shibazaki Takamasa、Noda Yuki、Kato Daiki、Nakada Takeo、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
- Journal Title
  
  Journal of Thoracic Disease
  
  Volume: 11 Issue: 9 Pages: 3738-3745
- DOI
  10.21037/jtd.2019.09.32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08581
[Journal Article] Risk factors for recurrence of primary spontaneous pneumothorax after thoracoscopic surgery2019
- Author(s)
  Asano Hisatoshi、Ohtsuka Takashi、Noda Yuki、Kato Daiki、Mori Shohei、Nakada Takeo、Matsudaira Hideki
- Journal Title
  
  Journal of Thoracic Disease
  
  Volume: 11 Issue: 5 Pages: 1940-1944
- DOI
  10.21037/jtd.2019.04.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08581
[Journal Article] Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis2019
- Author(s)
  Tsubouchi K、Araya J、Yoshida M、Sakamoto T、Koumura T、Minagawa S、Hara H、Hosaka Y、Ichikawa A、Saito N、Kadota T、Kurita Y、Kobayashi K、Ito S、Fujita Y、Utsumi H、Hashimoto M、Wakui H、Numata T、Kaneko Y、Mori S、Asano Hi、Matsudaira H、Ohtsuka T、Nakayama K、Nakanishi Y、Imai H、Kuwano K
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 8 Pages: 2076-2087
- DOI
  10.4049/jimmunol.1801232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581, KAKENHI-PROJECT-18K14906
[Journal Article] Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis2019
- Author(s)
  Saito N、Araya J、Ito S、Tsubouchi K、Minagawa S、Hara H、Ito A、Nakano T、Hosaka Y、Ichikawa A、Kadota T、Yoshida M、Fujita Y、Utsumi H、Kurita Y、Kobayashi K、Hashimoto M、Wakui H、Numata T、Kaneko Y、Asano H、Odaka M、Ohtsuka T、Morikawa T、Nakayama K、Kuwano K.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 5 Pages: 1428-1440
- DOI
  10.4049/jimmunol.1801293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08188, KAKENHI-PROJECT-18K08581
[Journal Article] The prevention of tracheal graft occlusion using pioglitazone: A mouse tracheal transplant model study.2019
- Author(s)
  Shigenobu T, Ohtsuka T ,Shimoda M
- Journal Title
  
  Transplant Immunology
  
  Volume: 53 Pages: 21-27
- DOI
  10.1016/j.trim.2018.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10800, KAKENHI-PROJECT-18K08581
[Journal Article] Demographics, Safety and Quality, and Prognostic Information in Both the Seventh and Eighth Editions of the TNM Classification in 18,973 Surgical Cases of the Japanese Joint Committee of Lung Cancer Registry Database in 20102019
- Author(s)
  Okami Jiro、Shintani Yasushi、Okumura Meinoshin、Ito Hiroyuki、Ohtsuka Takashi、Toyooka Shinichi、Mori Takeshi、Watanabe Shun-ichi、Date Hiroshi、Yokoi Kohei、Asamura Hisao、Nagayasu Takeshi、Miyaoka Etsuo、Yoshino Ichiro
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 14 Issue: 2 Pages: 212-222
- DOI
  10.1016/j.jtho.2018.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08581
[Journal Article] Attenuation of lung ischemia-reperfusion injury by Rho-associated kinase inhibition in a rat model of lung transplantation.2014
- Author(s)
  Kohno M, Watanabe M, Goto T, Kamiyama I, Ohtsuka T, Tasaka S, Sawafuji M.
- Journal Title
  
  Annals of thoracic and cardiovascular surgery
  
  Volume: 未定
- NAID
  130003387995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462183
[Presentation] Pioglitazone Induces Infiltrations of Regulatory T Cells in the Tracheal Graft and Attenuates Allograft Rejection2019
- Author(s)
  Takashi Ohtsuka
- Organizer
  International society for heart and lung transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10800
[Presentation] Peroxisome proliferator-activated receptor（PPAR）-γアゴニストによるマウス気管移植での拒絶反応抑制2019
- Author(s)
  大塚　崇
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10800
[Presentation] Pioglitazone induces infiltrations of regulatory T cells in the tracheal graft and attenuates allograft rejection.2019
- Author(s)
  Takashi Ohtsuka
- Organizer
  39th annual meeting of International society of heart and lung transplantation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10800
[Presentation] Peroxisome proliferator-activated receptor（PPAR）-γアゴニストによるマウス気管移植での拒絶反応抑制2019
- Author(s)
  大塚　崇
- Organizer
  第119回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10800
[Presentation] Pioglitazone投与による気管移植動物モデルの拒絶反応抑制，FoxP3陽性細胞の集積2015
- Author(s)
  重信敬夫　大塚　崇
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-04-15
- Data Source
  KAKENHI-PROJECT-26462134
[Presentation] Pioglitazone投与による期間移植動物モデルの拒絶反応抑制、FoxP3陽性細胞の集積2015
- Author(s)
  重信敬夫、大塚　崇
- Organizer
  第１１５回日本外科学会定期学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-15
- Data Source
  KAKENHI-PROJECT-26462134
[Presentation] CORM-2のBOに対する抑制効果2013
- Author(s)
  大塚　崇
- Organizer
  日本呼吸器外科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23791577
[Presentation] Carbon Monoxide-Releasing Molecule Attenuates Allograft Airway Rejection2012
- Author(s)
  大塚　崇
- Organizer
  International society of Heart and Lung transplantation
- Place of Presentation
  チェコ　プラハ
- Data Source
  KAKENHI-PROJECT-23791577
[Presentation] Wate-soluble carbon monoxide-releasing molecule attenuates allograft airway rejection2012
- Author(s)
  Takashi Ohtsuka, Taichiro Goto, Masaki Anraku, Mitsutomo Kohno, Hiroaki Nomori
- Organizer
  International society of heart and lung transplantation
- Place of Presentation
  プラハチェコ
- Year and Date
  2012-04-17
- Data Source
  KAKENHI-PROJECT-23791577
[Presentation] マウス気管移植(同所と異所)によるbronchiolitis obliterans モデルの検討Tracheal allograft oblitaration in a murine tracheal transplant model2011
- Author(s)
  大塚崇、後藤太一郎、安樂真樹、河野光智、泉陽太郎、堀之内宏久、野守裕明
- Organizer
  第64回日本胸部外科学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-09
- Data Source
  KAKENHI-PROJECT-23791577

1. SHIMODA MASAYUKI (70383734)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. ANRAKU Masaki (70598557)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KOHNO Mitsutomo (10276272)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. WATANABE Masazumi (90201227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. GOTO Taichiro (80317148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKUI Masayuki (30594494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Yusuke (00445214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKAI Hiromi (70318830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Asakura Keisuke (90383786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOBAYASHI Koichi (80051704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWAMURA Masafumi (70169770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HORINOUCHI Hirohisa (60173647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIGEMATSU Naoyuki (30178868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAMOTO Manabu (10317159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Kimura Naritaka (90348657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 羽藤泰 (10365281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 重信敬夫 (50626702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 涌井昌俊 (90240465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山内徳子 (30306732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 久保健一郎 (20348791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 西村知泰 (90348649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 橋本浩平 (70464964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KANAI Yae

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. OKADA Yasunori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ARAYA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 中山勝敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ohtsuka Takashi 大塚 崇

OHTSUKA Takashi 大塚 崇

大塚 崇 オオツカ タカシ

Research Projects

Research Products

Co-Researchers

個細胞空間的degradome解析に基づくプロテアーゼを介したがん免疫制御の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Amelioration of acute lung injury by lung mesenchymal stem cell and carbon monoxide.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a new method using carbon monoxide aiming at long-term preservation of donor heart for heart transplantation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Amelioration of rejection after lung transplant by newly developed gas carrier.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cancer-associated fibroblasts from the perspective of proteinases and epigenetics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ameliorating bronchiolitis oblietrans after transplantation using hemoglobin vesicles by controlling ADAM/MMP expressions.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The cytostatic effects of zoledronic acid on ACC-MESO-1 cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of oxygen infusion with hemoglobin vesicles on respiratory insufficiency

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of E-selectin in reimplantation lung injury

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of Carbon monoxide and Adenosine receptor in bronchiolitis obliterans in mice trachea transplantation model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺癌の浸潤、転移におけるプロテアーゼの関与の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

人工酸素運搬体と血管新生抑制物質の併用による腫瘍抑制効果の測定Principal Investigator

Principal Investigator

Ohtsuka Takashi 大塚崇

OHTSUKA Takashi 大塚崇

大塚崇オオツカタカシ