Shigematsu Naoyuki 茂松直之

… Alternative Names

Researcher Number	30178868
Other IDs
External Links
Affiliation (Current)	2019: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 慶應義塾大学, 医学部(信濃町), 教授 2009 – 2015: Keio University, 医学部, 教授 2002: Keio Univ., School of Medicine, Associate Professor, 医学部, 講師 2001: Radiology, School of Medicine, Keio University Lecture, 医学部, 助手 2000: School of Medicine, KEIO University Associate Professor, 医学部, 専任講師 … More
Review Section/Research Field	Principal Investigator Radiation science / Radiation science / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / General surgery
Keywords	Principal Investigator 放射線治療 / 放射線生物学 / 放射線照射 / 増感剤 / 放射線増感剤 / 胃癌 / 遺伝子突然変異 / LET / アポトーシス / Radiotherapy … More Except Principal Investigator 放射線感受性 / 放射線療法 / 放射線治療 / リンパ球 / Radiotherapy / Lymphocyte / LET / 人工酸素運搬体 / artificial oxygen carrier / chemotherapy / 晩期放射線障害 / 線維芽細胞 / 障害予測因子 / 放射線慢性障害 / 慢性放射線障害 / 耐用線量 / 光学的生存率測定 / 初代培養細胞 / Late radiation injury / Fibroblast / Predictive assay / 炭素粒子線 / ネオン粒子線 / 突然変異 / hprt / 重粒子線 / 培養細胞 / Carbon beamd / Neon beams / Mutation / 腫瘍の酸素化 / 抗癌剤感受性試験 / 感受性の増強 / 化学療法 / 腫瘍細胞の酸素化 / oxygenations of tumors / drug sensitivity test / increment of sensitivity / FISH法 / 染色体変異 / カリクレインA / カリクレイン / FISH method / Transformation / Radiosensitivity / Calicurein A / ラット / 腫瘍 / LY-80 / 抗癌剤 / LK-80 / 腫瘍内酸素分圧 / 腫瘍循環 / 動脈内注入 / 補助科学療法 / rat / tumor / Ly-80 / radiation Less

クロロキンのドラッグリポジショニングによる新規放射線増感治療の開発Principal InvestigatorOngoing
- Principal Investigator
  
  茂松直之
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Development of tumor-specific innovative drug Metformin for gastric cancer cell linesPrincipal Investigator
- Principal Investigator
  
  Shigematsu Naoyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Keio University
Radiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitorsPrincipal Investigator
- Principal Investigator
  
  SHIGEMATSU Naoyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Keio University
Administration of a hypoxic cell sensitizer, 6-FP, enhance of radiation-induced apoptosis in human carcinomaPrincipal Investigator
- Principal Investigator
  
  SHIGEMATSU Naoyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Keio University
Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  KEIO UNIVERSITY
Application of Modified FISH to Analyze Tumor Cell Radioresistance and Development of Its Clinical Application
- Principal Investigator
  
  ITO Hisao
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
PREDICTIVE SCREENING ASSAY FOR RADIATION INDUCED DAMAGES CAUSED BY CLINICAL RADIOTHERAPYPrincipal Investigator
- Principal Investigator
  
  SHIGEMATSU Naoyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  KEIO University
Tumor oxygenation to in crease sensitivity to anti-cancerous drug by using artificial oxygen carrier
- Principal Investigator
  
  KOBAYASHI Koichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General surgery
- Research Institution
  Keio University
EVALUATION OF APOPTOSIS RELATED GENE AND MUTATION INDUCTION FATER IRRADIATION.Principal Investigator
- Principal Investigator
  
  SHIGEMATSU Naoyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  KEIO University
Analysis of Redioresistant Tumor by Heavy Particle Irradiation
- Principal Investigator
  
  ITO Hisao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Keio University
Predictive assay for late radiation injury with fibroblast and lymphocyte
- Principal Investigator
  
  ITO Hisao
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  School of Medicine, Keio University

All 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation

[Journal Article] Pleural contact decreases survival in clinical T1N0M0 lung cancer patients undergoing SBRT.2019
- Author(s)
  Eriguchi T, Takeda A, Tsurugai Y, Sanuki N, Kibe Y, Hara Y, Kaneko T, Taguri M, Shigematsu N.
- Journal Title
  
  Radiother Oncol
  
  Volume: 134 Pages: 191-198
- DOI
  10.1016/j.radonc.2019.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07771
[Journal Article] A Highly Advanced Gastric Cancer Maintaining a Clinical Complete Response after Chemoradiotherapy Comprising S-1 and Cisplatin.2018
- Author(s)
  Yura Masahiro、Takahashi Tsunehiro、Fukuda Kazumasa、Nakamura Rieko、Wada Norihito、Fukada Junichi、Kawakubo Hirofumi、Takeuchi Hiroya、Shigematsu Naoyuki、Kitagawa Yuko
- Journal Title
  
  Case Rep Gastroenterol
  
  Volume: 12 Pages: 578-585
- DOI
  10.1159/000492206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10492, KAKENHI-PROJECT-18K07771
[Journal Article] Prostate-specific antigen nadir within 12 months as an early surrogate marker of biochemical failure and distant metastasis after low-dose-rate brachytherapy or external beam radiotherapy for localized prostate cancer.2018
- Author(s)
  Nishimura S, Ohashi T, Momma T, Sakayori M, Eriguchi T, Tanaka T, Yamashita S, Kosaka T, Oya M, Shigematsu N
- Journal Title
  
  Cancer Med
  
  Volume: 7 Pages: 1794-1801
- DOI
  10.1002/cam4.1443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07771
[Journal Article] Long-term Clinical Results of Concurrent Chemoradiotherapy for Patients with Cervical Esophageal Squamous Cell Carcinoma2017
- Author(s)
  Atsuhiro Kumabe, Sadatomo Zenda, Atsushi Motegi, Masakatsu Onozawa, Naoki Nakamura, Takashi Kojima, Hiroyuki Daiko, Naoyuki Shigematsu, and Tetsuo Akimoto
- Journal Title
  
  Anticancer Research
  
  Volume: 37(9) Pages: 5039-5044
- DOI
  10.21873/anticanres.11919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10411, KAKENHI-PROJECT-15K10008
[Journal Article] Long-term results of concurrent chemoradiotherapy with daily-low-dose continuous infusion of 5-fluorouracil and cisplatin (LDFP) for Stage I-II esophageal carcinoma2017
- Author(s)
  Kumabe A、Fukada J、Kota R、Koike N、Shiraishi Y、Seki S、Yoshida K、Kitagawa Y、Shigematsu N
- Journal Title
  
  Diseases of the Esophagus
  
  Volume: 31 Pages: 1-8
- DOI
  10.1093/dote/dox138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10008
[Journal Article] Clinical evidence of particle beam therapy2012
- Author(s)
  Shigematsu N, Shiraishi Y., Seki S., Fukada J., Ohashi T
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 17(2) Pages: 75-78
- NAID
  10030626272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591619
[Journal Article] Impact of MRI-based postimplant dosimetric assessment in prostate brachytherapy using contrast-enhanced T1-weighted images2012
- Author(s)
  Ohashi T., Momma T., Yamashita S., Nagatusma K., Kanai K., Kitagawa K., Takahashi S., Hanada T., Yorozu A., Shigematsu N
- Journal Title
  
  Brachytherapy
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591619
[Presentation] ステージI-II期食道癌に対する化学放射線療法2017
- Author(s)
  外山弘文、深田淳一、隈部篤寛、公田龍一、小池直義、白石悠、北川雄光、茂松直之
- Organizer
  日本放射線腫瘍学会第30回学術大会
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] Pleural and pericardial effusion after chemoradiotherapy in esophageal cancer patients. A predictive modeling using mean pericardial irradiated dose2016
- Author(s)
  J. Fukada, T. Abe, A. Kumabe, H. Takaishi, Y. Kitagawa,N. Shigematsu
- Organizer
  57th Annual Meeting of American Society for Therapeutic Radiology and Oncology
- Place of Presentation
  ボストン(アメリカ合衆国）
- Year and Date
  2016-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] Chromosomal Aberrations in Normal and AT Cells Exposed to High Dose of Low-dose-rate Irradiation2015
- Author(s)
  Kawata T, Liu C, Fukada J, Kota R, Shigematsu N
- Organizer
  International congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] adiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitors2015
- Author(s)
  Fukada J, Kota R, Mishima M, Kawata T, Shigematsu N
- Organizer
  International congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] 食道癌化学放射線治療後の心嚢水・胸水貯留-平均心嚢照射線量を用いた予測モデル-2015
- Author(s)
  深田淳一，阿部貴行，隈部篤寛，高石官均，北川雄光，茂松直之
- Organizer
  第53回癌治療学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] PI3K/AKT/mTOR inhibitors enhance cytotoxic effect in combination with radiotherapy in gastric cancer cell lines2015
- Author(s)
  深田淳一, 公田龍一, 三島眞代, 川田哲也, 茂松直之
- Organizer
  日本放射線腫瘍学会第28回学術大会
- Place of Presentation
  ベイシア文化ホール（群馬県前橋市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] Cytogenetic Effects of Radiation and Caffeine on Normal Human Fibroblast and Ataxia Telangiectasia Heterozygous Fibroblast Cells2015
- Author(s)
  Shigematsu N, Fukada J, Kota R, Shiraishi Y, Kawata T
- Organizer
  International congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10008
[Presentation] Symptomatic pericardial effusion after chemoradiation therapy for esophageal cancer: A historical comparison.2013
- Author(s)
  Fukada J, Shigematsu N, Takeuchi H, Shiraishi Y, Hanada T, Ohashi T, Kota R, Kumabe A, Sutani S, Kitagawa Y.
- Organizer
  55th Annual Meeting of American Society for Therapeutic Radiology and Oncology
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-24591850
[Presentation] Inter- and intrafraction gastric motion study –Impact of breathing and stomach filling2012
- Author(s)
  J. Fukada, N. Shigematsu, T. Hanada, T. Ohashi, T. Tanaka, Y. Shiraishi, H. Takeuchi, Y. Kitagawa
- Organizer
  American society for radiation oncology 54th annual meeting
- Place of Presentation
  Boston convention and exhibition center, Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-24591850
[Presentation] Radiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitors
- Author(s)
  Junichi Fukada、Ryuichi Kota, Masayo Mishima, Tetsuya Kawata, Naoyuki Shigematsu
- Organizer
  International Congress of Radiation Reseach
- Place of Presentation
  国立京都国際会館
- Year and Date
  2015-05-25 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-24591850
[Presentation] 上腹部リンパ節の呼吸性移動－４ＤＣＴを用いた検討－
- Author(s)
  祝田勇輝、深田淳一、酢谷真也、花田剛士、高橋常浩、北川雄光、茂松直之
- Organizer
  日本放射線腫瘍学会第27回学術大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-24591850

1. ITO Hisao (20095574)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KAWATA Tetsuya (60234077)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. KUTUKI Shoji (00234443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUKADA Junichi (50338159)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
5. NAKAYAMA Toshitake (90189077)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TOYA Kazuhito (30265912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOBAYASHI Koichi (80051704)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. WATANABE Masazumi (90201227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HORINOUCHI Hirohisa (60173647)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NISHIMURA Shuichi (40571138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHIGUCHI Iku (20198451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OGAWA Koichi (00158817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KA Wei-Jei (10224320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAJIMA Atsushi (50276276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YASUDA Shigeo (20251176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKANO Hideyuki (40197116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. UNO Takashi (30302540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OSAMU Kawaguchi (90276428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ISHIBASHI Ryochi (90286584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KASAMATSU Tomotaka (30317242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KAWAMURA Masafumi (70169770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YAMAMOTO Manabu (10317159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 原竜介 (50312939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐藤導直 (80255554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 山内徳子 (30306732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 大塚崇 (40306717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 公田龍一 (00464834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 小池直義 (60464913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ISOBE Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MOTEGI Atushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 秋元哲夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shigematsu Naoyuki 茂松 直之

SHIGEMATSU Naoyuki 茂松 直之

Research Projects

Research Products

Co-Researchers

クロロキンのドラッグリポジショニングによる新規放射線増感治療の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of tumor-specific innovative drug Metformin for gastric cancer cell linesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Radiosensitization in gastric cancer cell lines using different PI3K/AKT/mTOR inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Administration of a hypoxic cell sensitizer, 6-FP, enhance of radiation-induced apoptosis in human carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of Modified FISH to Analyze Tumor Cell Radioresistance and Development of Its Clinical Application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PREDICTIVE SCREENING ASSAY FOR RADIATION INDUCED DAMAGES CAUSED BY CLINICAL RADIOTHERAPYPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tumor oxygenation to in crease sensitivity to anti-cancerous drug by using artificial oxygen carrier

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EVALUATION OF APOPTOSIS RELATED GENE AND MUTATION INDUCTION FATER IRRADIATION.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Redioresistant Tumor by Heavy Particle Irradiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Predictive assay for late radiation injury with fibroblast and lymphocyte

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pleural contact decreases survival in clinical T1N0M0 lung cancer patients undergoing SBRT.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Highly Advanced Gastric Cancer Maintaining a Clinical Complete Response after Chemoradiotherapy Comprising S-1 and Cisplatin.2018

Author(s)

Journal Title

DOI

Shigematsu Naoyuki 茂松直之

SHIGEMATSU Naoyuki 茂松直之