AZUMA Hiroshi 東寛

Researcher Number	00167909
Other IDs
Affiliation (Current)	2023: 旭川医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2021: 旭川医科大学, 医学部, 名誉教授 2019 – 2020: 旭川医科大学, 医学部, 特命教授 2013 – 2019: 旭川医科大学, 医学部, 教授 1995: Asahikawa Medical College, Department of Pediatrics, Associate, 医学部, 講師 1993: ASAHIKAWA MEDICAL COLLEGE DEPT PED, INSTRUCTOR, 医学部, 助手 1989 – 1991: 旭川医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Pediatrics
Keywords	Principal Investigator リポソーム / MDSC / B7-H3 / liposome / マクロファージ / iNOS / macrophage / NFkB / immunosuppression / ナノ粒子 … More / ectosome / regulatory macrophage / B7 family / CD276 / IL6 / 可溶性IL6レセプター / 脳脊髄液 / グリオブラストーマ / アストロサイトーマ / 単純ヘルペス感染症 / リポポリサッカライド / 中枢神経感染症 / チリオブラストーマ / interleukin 6 / soluble interleukin 6 receptor / cerebro spinal fluid / glioblastoma / astorcytoma / herpes simplex infection / liopolysaccharide / central nervous system infection / 抑制性マクロファージ / microvesicle / extosome / exosome / B7H3 / 刺激伝達系 / fatty acid / MAP kinase / micro vesicle / ER stress / MDSD … More Except Principal Investigator 概日リズム / 縮日リズム / 長日リズム / ゴナドトロピン / 成長速度 / テストステロン / 成長ホルモン / 170Hプロゲステロン / 性腺刺激ホルモン / 概日性リズム / 成長ホルモン欠損症 / タ-ナ-症候群 / 先天性副腎過形成 / 170Hプロケステロン / Circadian Rhythm / Ultradian Rhythm / Infradian Rhythm / Growth hormone / Gonadotropin / 17-Hydroxyprogesterone / Growth Velocity / 黄体化ホルモン / 卵胞刺激ホルモン / 思春期 / 二次性徴 / 性成熟 / インターロイキン / CIRCADIAN RHYTHM / ULTRADIAN RHYTHM / INFRADIAN RHYTHM / LETEINIZING HORMONE / FOLLICLE STIMULATING HORMONE / TESTOSTERONE / PUBERTY Less

Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppressionPrincipal Investigator
- Principal Investigator
  
  Azuma Hiroshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Asahikawa Medical College
Mechanism of B7-H3 expression on liposome induced MDSC-like cell and its influence on immunosuppressionPrincipal Investigator
- Principal Investigator
  
  Hiroshi Azuma
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikawa Medical College
Detection of molecules involved in the induction of immunosuppressive function of MDSC-like cells induced by liposomePrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikawa Medical College
Analysis of interleukin 6 and its soluble receptor in cerebrospinal fluidPrincipal Investigator
- Principal Investigator
  
  AZUMA Hiroshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikawa Medical College
STUDIES ON THE DEVELOPMENT OF CIRCADIAN, ULTARADINAN AND INFRADIAN RHYTHMS IN BIOLOGICAL ACTIVITY.
- Principal Investigator
  
  OKUNO Akimasa
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  ASAHIKAWA MEDICAL COLLEGE
Studies on the Development of Circadian and Ultradian Rhythms in the Hypothalamo-Pituitary System in Children and Adolescents
- Principal Investigator
  
  OKUNO Akimasa
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Asahikwa Medical College

All 2020 2019 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book Patent

[Book] Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics2014
- Author(s)
  Hiroshi Azuma, Mitsuhiro Fujihara, Hiromi Sakai
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461578
[Journal Article] Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells- Induction of MDSC by lipid vesicles (liposome)2020
- Author(s)
  Yoshida Y, Nagamori T, Ishibazaawa E, Kobayashi H, Kure T, Sakai H, Takahashi D, Fujihira F, Azuma h
- Journal Title
  
  IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  
  Volume: 42 Pages: 614-624
- DOI
  10.1080/08923973.2020.1837866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08854
[Journal Article] Liposomal micro particle injection can induce myeloid-derived suppressor cells(MDSC)-like cells in vivo2017
- Author(s)
  Azuma h, Yoshida Y, Takahashi H, Ishibazawa E, Kobayashi H, Sakai H, Takahashi D, Fujihara M
- Journal Title
  
  Immunopharm Immunot
  
  Volume: 39 Pages: 140-147
- DOI
  10.1080/08923973.2017.1306867
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461578, KAKENHI-PROJECT-16K10010
[Journal Article] Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function2017
- Author(s)
  Azuma H, Fujihara M, Sakai H
- Journal Title
  
  J Funct Biomate
  
  Volume: 8 Pages: 24-24
- DOI
  10.3390/jfb8030024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10010
[Journal Article] Primary and secondary immune response to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicles, an artificial oxygen carrier2013
- Author(s)
  Fujihara M, Takahashi D, Abe, H, Sakai H, Horinouchi H, KObayashi K, Ikeda H, Azuma H
- Journal Title
  
  Artif Organs
  
  Volume: 38 Pages: 234-238
- DOI
  10.1111/aor.12148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461578
[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015
- Inventor(s)
  東　　寛、酒井宏水
- Industrial Property Rights Holder
  旭川医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-04-01
- Data Source
  KAKENHI-PROJECT-25461578
[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015
- Inventor(s)
  東　寛、酒井宏水
- Industrial Property Rights Holder
  国立大学法人旭川医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-068296
- Filing Date
  2015-03-30
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] HbVを構成しているリポソームの細網内皮系細胞への取り込み機序の検討2020
- Author(s)
  東　　寛、酒井　宏水
- Organizer
  第27回日本血液代替物学会年次大会
- Data Source
  KAKENHI-PROJECT-19K08854
[Presentation] Induction of B7-H3 positive myeloid-derived suppressor cells(MDSC) by liposomal nanoparticles2019
- Author(s)
  Azuma H, Yoshida Y, Nagamori T, Ishibazawa E, Kobayashi H, Skai H, Takahashi D, Fujihara M
- Organizer
  The 17th international Symposium on Blood Substitute and Oxygen Therapeutics
- Invited
- Data Source
  KAKENHI-PROJECT-19K08854
[Presentation] HbVに使用されているリポソーム粒子のマクロファージへの影響について2017
- Author(s)
  東　　寛
- Organizer
  第24回日本血液代替物学会年次大会
- Data Source
  KAKENHI-PROJECT-16K10010
[Presentation] リポソームにより誘導される抑制性マクロファージの機能解析2016
- Author(s)
  東　寛
- Organizer
  第23回日本血液代替物学会
- Place of Presentation
  東京
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K10010
[Presentation] Membrane-derived microvesicleによる免疫抑制細胞(MSC)の誘導について2016
- Author(s)
  東　寛
- Organizer
  北日本小児科学会
- Place of Presentation
  弘前
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] Menbrane-derived microvesicleによる免疫抑制細胞(MDSC)の誘導について2016
- Author(s)
  東　寛
- Organizer
  北日本小児科学会
- Place of Presentation
  弘前
- Data Source
  KAKENHI-PROJECT-16K10010
[Presentation] リポソームにより誘導される抑制性マクロファージの機能解析2016
- Author(s)
  東　寛
- Organizer
  第23回日本血液代替物学会
- Place of Presentation
  東京
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 人工赤血球（ヘモグロビン小胞体）を構成する脂質２重膜の薬理作用について2015
- Author(s)
  東　　寛、吉田陽一郎、高橋弘典、高橋大輔、藤原満博、酒井宏水
- Organizer
  日本血液代替物学会
- Place of Presentation
  熊本
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] リポソームの投与後の脾細胞からCon A刺激により産生されるサイトカイン・ケモカイン動態の網羅的解析2013
- Author(s)
  東　　寛, 高橋弘典, 永井一樹, 長森恒久, 高橋大輔, 藤原満博, 酒井宏水
- Organizer
  第20回日本血液代替物学会年次大会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 人工赤血球(ヘモグロビン小胞体）を構成する脂質２重膜のもつ免疫調節効果について2013
- Author(s)
  東　　寛, 　酒井宏水
- Organizer
  第20回日本血液代替物学会年次大会
- Place of Presentation
  奈良県新公会堂
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 輸血治療を補完する人工赤血球の効力と安全性
- Author(s)
  東　寛、藤原満博、酒井宏水
- Organizer
  第62回日本輸血細胞治療学会
- Place of Presentation
  奈良
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25461578
[Presentation] 人工赤血球製剤（ヘモグロビン小胞体）の効能を安全性
- Author(s)
  東　寛
- Organizer
  第21回日本血液代替物学会
- Place of Presentation
  東京
- Year and Date
  2014-12-08 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461578

1. 酒井宏水 (70318830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. OKUNO Akimasa (10000960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OKI Junichi (60152401)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YANO Koichi (60182383)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OKA Toshiaki (30111206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 長森恒久 (40400098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 高橋弘典 (50431408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 岡嶋一樹 (70213931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 更科岳大 (40431407)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 吉田陽一郎 (80750306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OKA Ryuji (40113724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KAKUYA Fujio (70240645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ITO Yoshiya (70241437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 古谷野伸 (30312458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鳥海尚久 (30516399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 佐々木一弘

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 鈴木直己

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AZUMA Hiroshi 東 寛

Research Projects

Research Products

Co-Researchers

Search into the mechanism of B7-H3 expressing MDSC generation by liposome and its T cell suppressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of B7-H3 expression on liposome induced MDSC-like cell and its influence on immunosuppressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of molecules involved in the induction of immunosuppressive function of MDSC-like cells induced by liposomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of interleukin 6 and its soluble receptor in cerebrospinal fluidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDIES ON THE DEVELOPMENT OF CIRCADIAN, ULTARADINAN AND INFRADIAN RHYTHMS IN BIOLOGICAL ACTIVITY.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the Development of Circadian and Ultradian Rhythms in the Hypothalamo-Pituitary System in Children and Adolescents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics2014

Author(s)

Publisher

Data Source

[Journal Article] Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells- Induction of MDSC by lipid vesicles (liposome)2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liposomal micro particle injection can induce myeloid-derived suppressor cells(MDSC)-like cells in vivo2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biocompatibility of HbV: Liposome-Encapsulated Hemoglobin Molecules-Liposome Effects on Immune Function2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Primary and secondary immune response to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicles, an artificial oxygen carrier2013

Author(s)

Journal Title

DOI

Data Source

[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロフ ァージの誘導方法2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージ の誘導方法2015

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] HbVを構成しているリポソームの細網内皮系細胞への取り込み機序の検討2020

Author(s)

Organizer

AZUMA Hiroshi 東寛

[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015

[Patent] リポソームを含有する免疫抑制剤及びこれを用いた抑制性マクロファージの誘導方法2015