Miyaki Shigeru 味八木茂

… Alternative Names

MIYAKI Shigeru 味八木茂

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Researcher Number	10392490
Other IDs
Affiliation (Current)	2022: 広島大学, 病院(医), 講師
Affiliation (based on the past Project Information) *help	2015 – 2022: 広島大学, 病院(医), 講師 2017: 広島大学, 病院, 講師 2013 – 2015: 広島大学, 病院, 講師 2012 – 2015: 広島大学, 大学病院, 講師 2012: 広島大学, 病院(医), 講師 … More 2011: 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 共同研究員 2010: 独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 研究員 2009: 国立成育医療センター(研究所), 移植・外科研究部, 共同研究員 2008 – 2009: 国立成育医療センター(研究所), 移植・外科研究部, 研究員 2007: 国立成育医療センター(研究所), 移植・外科研究部, 共同研究員 2005 – 2006: 国立成育医療センター(研究所), 移植外科研究部, 流動研究員 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Biological Sciences / Food science / Applied health science / Laboratory animal science / Complex Systems Disease Theory / Basic Section 38050:Food sciences-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Transformative Research Areas, Section (IV) / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator microRNA / 変形性関節症 / エクソソーム / マイクロRNA / 軟骨 / 軟骨細胞 / 組織再生 / 間葉系幹細胞 / 滑膜 / 関節病態 … More / マイクロＲＮＡ / 酸化ストレス / ヘムオキシゲナーゼ-１ / SOD2 / アポトーシス / 抗酸化 / ジンクフィンガープロテイン / HO-1 / 糖鎖 / マイクロENA / 腱 / 靭帯 / Dicer / Scleraxis / 発生・成熟 / 組織修復 / 腱・靭帯 / 組織再生・修復 / 再生 / 細胞老化 / ドラックリポジショニング / 機械学習 / 老化細胞 … More Except Principal Investigator microRNA / エクソソーム / 再生医学 / 変形性関節症 / 発生・分化 / 転写因子 / 関節軟骨 / マイクロRNA / 関節病学 / 血管新生 / 骨肉腫 / 抗老化 / 食品機能成分 / 幹細胞 / 遺伝子発現 / 骨成長 / 間葉系幹細胞 / miRNA / 脊椎脊髄病学 / カルノシン酸 / トランスサイレチン / アミロイド / 老化 / 軟骨再生 / 再生医療 / クロマチン / 発現制御 / 応用動物 / 遺伝子 / 軟骨 / 骨・軟骨代謝 / 四肢 / 肢芽 / 骨・軟骨代謝学 / Mohawk / 腱 / 靭帯 / 血管再生 / ｴｸｿｿｰﾑ / 転移 / 脱細胞化 / 末梢血単核球 / エクソソーﾑ / 変形性関節性 / 組織再生 / 筋・神経病学 / 運動器外傷学 / 脊髄脊髄病学 / オートファジー / FoxO3a / 運動器 / 脳機能 / 老齢疾患 / 脳 / 膝関節 / 肝臓 / スルフォラファン / 光干渉断層法 / 軟骨組織 / 定量評価 / 離断性骨軟骨炎 / 光診断 / 磁気ターゲッティング / 難治性骨折 / 骨壊死 / 単核球 / 細胞移植 / 脊髄損傷 / 小胞体ストレス / OASIS / グリオーシス / Exosome / 運動 / 食品 / 骨粗鬆症 / 血中マーカー / 数理モデル / 画像解析 / 骨代謝マーカー / 予測シミュレーション / 数理シミュレーション / 骨代謝 / 軟骨代謝 / シミュレーション / 変形性関節症（OA） / 神経ペプチド / MSC由来エクソソーム / デリバリーシステム / homing機能 / homing / MSC / ホーミング / 特発性大腿骨頭壊死症 / 診断マーカー / 大腿骨頭壊死症 / MicroRNA / 血清 / 組織液 / 腸 / マイクロニードルアレイシート / ドラックデリバリー / 腱・靭帯 / 腱修復 / 幹細胞老化 / 筋衛星細胞 / ゲノム解析 / 組織幹細胞 / 転写制御 / 骨棘 / ドキソルビシン / プロドラッグ / 心毒性 / 骨髄抑制 / レチノイン酸 / 骨形成 / 化合物群 / シナジー効果 / AI / 組み合わせ / 最適化 / 骨格幹細胞 / 軟骨損傷 / 椎体終板障害 / 腰痛 / 切断四肢保存 / 自己血灌流 Less

変形性関節症における骨棘軟骨を用いた新規軟骨再生医療の確立
- Principal Investigator
  
  中佐智幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
低酸素下でのみ薬剤を遊離作用可能にしたプロドラッグを用いた骨肉腫治療の開発
- Principal Investigator
  
  古田太輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
レチノイン酸による骨の形成・維持の制御メカニズムの解明と臨床応用への発展
- Principal Investigator
  
  内部健太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Hiroshima University
関節軟骨維持・再生に関わる骨格幹細胞の同定
- Principal Investigator
  
  安達伸生
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Hiroshima University
microRNAを介した腰椎椎体終板障害の機能解明および新たな治療戦略の確立
- Principal Investigator
  
  中前稔生
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
切断四肢保存のための人工赤血球灌流療法の開発
- Principal Investigator
  
  四宮陸雄
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
Study on the mechanisms of anti-aging food compounds by suppressing amyloid formation in gut
- Principal Investigator
  
  松原主典
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Hiroshima University
Development a novel approach for articular cartilage repair/regeneration using microneedle array sheet
- Principal Investigator
  
  石川正和
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
腱・靭帯の分子生物学的情報を基盤とした新たな治療法の開発
- Principal Investigator
  
  安達伸生
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
運動器における幹細胞老化の理解と制御
- Principal Investigator
  
  寺村岳士
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kindai University
Search and design of compounds with synergistic effects by AI
- Principal Investigator
  
  山西芳裕
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  Kyushu Institute of Technology
Development of a novel delivery system and osteosarcoma therapy using down-regulated MSC-derived exosomes
- Principal Investigator
  
  Furuta Taisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
New strategy for the diagnosis of osteonecrosis of the femoral head
- Principal Investigator
  
  Shoji Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
The role of chondrocyte/senescent cells-derived exosomal microRNA in pathogenesis of osteoarthritis, and in silico drug discoveryathogenesis of osteoarthritis and in silico drug discoveryPrincipal Investigator
- Principal Investigator
  
  Miyaki Shigeru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
Systems Bone Biology
- Principal Investigator
  
  Shinohara Masahiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Therapeutic strategy for osteoarthritis by targeting neuropeptides.
- Principal Investigator
  
  Nakasa Tomoyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
Anti-aging effect of transthyretin stabilizing food-derived bioactive compounds
- Principal Investigator
  
  Matsubara Kiminori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Hiroshima University
Elucidation and control of gliosis mechanism after spinal cord injury via endoplasmic reticulum stress sensor OASIS
- Principal Investigator
  
  Kamei Naosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Development of articular cartilage repair using minced cartilage and microRNA/exosomes
- Principal Investigator
  
  Adachi Nobuo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Analysis of novel communication factor exosomes for the treatment and diagnosis of osteoarthritis(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  MIYAKI Shigeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
The role of microRNA in maturation of tendon /ligamentPrincipal Investigator
- Principal Investigator
  
  MIYAKI Shigeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Search for early marker of Osteoarthritis using Exosome and establish monitoring index of exercise and nutritional effects
- Principal Investigator
  
  ISHITOBI Hiroyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
  Laboratory animal science
- Research Institution
  Kyoto Sangyo University
  The University of Tokyo
Acceleration of bone repair using miRNA-induced bone marrow cells for osteonecrosis
- Principal Investigator
  
  YAMASAKI Takuma
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Analysis of novel communication factor exosomes for the treatment and diagnosis of osteoarthritisPrincipal Investigator
- Principal Investigator
  
  MIYAKI Shigeru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Preventive effect of food-derived bioactive compounds with anti-angiogenic and autophagy activities on aging.
- Principal Investigator
  
  Matsubara Kiminori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Hiroshima University
Development of a novel diagnostic system for osteochondritis dissecans of the knee using optical coherence tomography
- Principal Investigator
  
  ISHIKAWA Masakazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
The strategy for refractory fracture using the combination of microRNA with magnetic targeting system
- Principal Investigator
  
  OCHI MITSUO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
The role of exosomes as a novel communication factor in tissue regeneration
- Principal Investigator
  
  OCHI MITSUO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Development of new treatments using pro-angiogenic and tissue-specific microRNAs for the injury of musculoskeletal and nerve tissue
- Principal Investigator
  
  KAMEI NAOSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Bach1 deficiency reduces severity of osteoarthritis, and induction of HO-1 is a novel target in OA prevention.Principal Investigator
- Principal Investigator
  
  MIYAKI Shigeru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Therapeutic strategy based on angiogenesis induce by microRNA in orthopaedic field
- Principal Investigator
  
  NAKASA Tomoyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Exosome-formed miRNA for the treatment of osteosarcoma
- Principal Investigator
  
  SHIMOSE Shoji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
cartilage regeneration using decellularized tissue, peripheral blood mononuclear cell, and microRNA
- Principal Investigator
  
  OCHI Mitsuo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
Exosomes including microRNA as a new mediators of communication among joint cells in OA pathogenesisPrincipal Investigator
- Principal Investigator
  
  MIYAKI Shigeru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hiroshima University
四肢前後軸を形成する転写ネットワークの解析
- Principal Investigator
  
  横山成俊
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Research Institute for Child Health and Development
Elucidation for mechanisms of development and regeneration in tendon and ligament
- Principal Investigator
  
  ASAHARA Hiroshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Research Institute for Child Health and Development
Non-coding RNAs regulating cartilage development
- Principal Investigator
  
  ASAHARA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Research Institute for Child Health and Development
腱の発生・再生に関わるホメオボックス遺伝子Mohawkの機能解析
- Principal Investigator
  
  浅原弘嗣 (淺原弘嗣), 工藤寛枝
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Research Institute for Child Health and Development
核内蛋白質のクロマティン因子および成長因子としての内軟骨性骨化における役割の解明
- Principal Investigator
  
  淺原弘嗣 (浅原弘嗣)
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Research Institute for Child Health and Development
ヒト骨髄由来間葉系幹細胞におけるmicroRNAによる分化制御の網羅的解析
- Principal Investigator
  
  ASAHARA Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Research Institute for Child Health and Development
核内蛋白HMGB1の成長因子としての骨分化におけるメカニズムの解明
- Principal Investigator
  
  浅原弘嗣
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Research Institute for Child Health and Development
新規Znフィンガープロテインの機能解析による軟骨発生・分化のメカニズムの解明
- Principal Investigator
  
  浅原弘嗣 (淺原弘嗣)
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Research Institute for Child Health and Development

[Book] 変形性関節症の診断と治療　別冊整形外科672015
- Author(s)
  味八木　茂
- Total Pages
  222
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-24689057
[Journal Article] The therapeutic capacity of bone marrow MSC-derived extracellular vesicles in Achilles tendon healing is passage-dependent and indicated by specific glycans.2022
- Author(s)
  Hayashi Y, Yimiti D, Sanada Y, Ding C, Omoto T, Ogura T, Nakasa T, Ishikawa M, Hiemori K, Tateno H, Miyaki S, Adachi N.
- Journal Title
  
  FEBS Lett.
  
  Volume: 596(8) Pages: 1047-1058
- DOI
  10.1002/1873-3468.14333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22740, KAKENHI-PROJECT-20H03805
[Journal Article] Pharmacological Targeting of Heme Oxygenase-1 in Osteoarthritis.2021
- Author(s)
  Sanada Yohei, Tan Sho Joseph Ozaki, Adachi Nobuo, Miyaki Shigeru
- Journal Title
  
  Antioxidants (Basel)
  
  Volume: 10 Pages: 419-419
- DOI
  10.3390/antiox10030419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16223, KAKENHI-PROJECT-19H03785
[Journal Article] Therapeutic effect of targeting Substance P on the progression of osteoarthritis2021
- Author(s)
  Shirakawa Y, Nakasa T, Kanemitsu M, Nekomoto A, Ishikawa M, Yimiti D, Miyaki S, Adachi N.
- Journal Title
  
  Mod Rheumatol
  
  Volume: －
- DOI
  10.1093/mr/roab089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03785
[Journal Article] Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone.2020
- Author(s)
  Kanemitsu M, Nakasa T, Shirakawa Y, Ishikawa M, Miyaki S, Adachi N
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09066
[Journal Article] Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis2020
- Author(s)
  Nagira Keita, Ikuta Yasunari, Shinohara Masahiro, Sanada Yohei, Omoto Takenori, Kanaya Haruhisa, Nakasa Tomoyuki, Ishikawa Masakazu, Adachi Nobuo, Miyaki Shigeru, Lotz Martin
- Journal Title
  
  Sci Rep
  
  Volume: 10 Pages: 10077-10077
- DOI
  10.1038/s41598-020-66979-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16223, KAKENHI-PROJECT-19H03785, KAKENHI-PROJECT-19H03991
[Journal Article] Role of vasoactive intestinal peptide in the progression of osteoarthritis through bone sclerosis and angiogenesis in subchondral bone2020
- Author(s)
  Kanemitsu Munekazu、Nakasa Tomoyuki、Shirakawa Yoshiko、Ishikawa Masakazu、Miyaki Shigeru、Adachi Nobuo
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 25 Pages: 897-906
- DOI
  10.1016/j.jos.2019.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09066
[Journal Article] Repair of an osteochondral defect with minced cartilage embedded in atelocollagen gel: rabbit model.2019
- Author(s)
  Matsushita R, Nakasa T, Ishikawa M, Tsuyuguchi Y, Matsubara N, Miyaki S, Adachi N.
- Journal Title
  
  American Journal of Sports Medicine
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-17H04314
[Journal Article] Repair of an Osteochondral Defect With Minced Cartilage Embedded in Atelocollagen Gel: A Rabbit Model.2019
- Author(s)
  Matsushita R, Nakasa T, Ishikawa M, Tsuyuguchi Y, Matsubara N, Miyaki S, Adachi N.
- Journal Title
  
  Am J Sports Med.
  
  Volume: 47(9) Pages: 2216-2224
- DOI
  10.1177/0363546519854372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04314
[Journal Article] The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration.2018
- Author(s)
  Tsuyuguchi Y, Nakasa T, Ishikawa M, Miyaki S, Matsushita R, Kanemitsu M, Adachi N.
- Journal Title
  
  Cartilage
  
  Volume: Epub ahead of print
- DOI
  10.1177/1947603518805205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04314
[Journal Article] A novel Mucidosphaerium sp. from Beppu hot spring down-regulates inflammatory gene expression in skin and articular cells2018
- Author(s)
  Miyata M, Iwata S, Mifude C, Tajima M, Kameyama M, Ihara M, Matsui T, Yamagishi S, Ishitobi H, Miyaki S, Kaseda K
- Journal Title
  
  Alternative therapies in health and medicine
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21192
[Journal Article] Extracellular vesicles in cartilage homeostasis and osteoarthritis2018
- Author(s)
  Miyaki S, Lotz MK.
- Journal Title
  
  Curr Opin Rheumatol
  
  Volume: 1 Pages: 129-135
- DOI
  10.1097/bor.0000000000000454
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959, KAKENHI-PROJECT-15KK0308
[Journal Article] Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes2018
- Author(s)
  Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, Lotz MK, Matsubara K, Miyaki S, Adachi N.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 830 Pages: 1-8
- DOI
  10.1016/j.ejphar.2018.04.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959, KAKENHI-PROJECT-15KK0308, KAKENHI-PROJECT-18K17873, KAKENHI-PROJECT-18K17990
[Journal Article] 食品機能成分による加齢性疾患の予防効果2017
- Author(s)
  松原主典、柴田紗知、味八木茂
- Journal Title
  
  細胞
  
  Volume: 49 Pages: 502-505
- NAID
  40021807800
- Data Source
  KAKENHI-PROJECT-17K07791
[Journal Article] Mitochondrial Regulation in the Pathogenic Process of Inflammatory Arthritis by Microalgal Mucidosphaerium Species2017
- Author(s)
  Chie K. M, Ishitobi H, Miyaki S and Kaseda K
- Journal Title
  
  Molecular Medicine: Current Aspects
  
  Volume: 1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21192
[Journal Article] The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice2017
- Author(s)
  Matsubara Kiminori、Okuda Mayumi、Shibata Sachi、Miyaki Shigeru、Ohkubo Takeshi、Izu Hanae、Fujii Tsutomu
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 82 Pages: 647-653
- DOI
  10.1080/09168451.2017.1403883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07791
[Journal Article] 食品機能成分による加齢性疾患の予防効果2017
- Author(s)
  松原主典、柴田紗知、味八木茂
- Journal Title
  
  アグリバイオ
  
  Volume: 1 Pages: 85-90
- NAID
  40021807800
- Data Source
  KAKENHI-PROJECT-17K07791
[Journal Article] <b>The role of tetraspanin CD9 in osteoarthritis using three different mouse </b><b>models </b>2016
- Author(s)
  Sumiyoshi N, Ishitobi H, Miyaki S, Miyado K, Adachi N, Ochi M.
- Journal Title
  
  Biomedical Research
  
  Volume: 37 Issue: 5 Pages: 283-291
- DOI
  10.2220/biomedres.37.283
- NAID
  130005432956
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959, KAKENHI-PROJECT-14J05729, KAKENHI-PROJECT-26293363, KAKENHI-PROJECT-26670733, KAKENHI-PROJECT-16K21192
[Journal Article] Carnosic acid protects starvation-induced SH- SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a2016
- Author(s)
  Shibata S, Ishitobi H, Miyaki S, Kawaoka T, Kayashima T, Matsubara K.
- Journal Title
  
  Int. J. Food Sci. Nutr.
  
  Volume: 8 Pages: 977-82
- DOI
  10.1080/09637486.2016.1208734
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J05729, KAKENHI-PROJECT-26450159, KAKENHI-PROJECT-16K21192
[Journal Article] Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model.2016
- Author(s)
  TAISUKE FURUTA, SHIGERU MIYAKI, HIROYUKI ISHITOBI, TOSHIHIKO OGURA, YOSHIO KATO, NAOSUKE KAMEI, KENJI MIYADO, YUKIHITO HIGASHI, MITSUO OCHI
- Journal Title
  
  Stem Cells Translational Medicine
  
  Volume: 5 Pages: 1620-1630
- DOI
  10.5966/sctm.2015-0285
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04365, KAKENHI-PROJECT-15H04959, KAKENHI-PROJECT-14J05729, KAKENHI-PROJECT-26293363, KAKENHI-PROJECT-16K21192
[Journal Article] Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-12015
- Author(s)
  Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, Lotz MK, Ochi M.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 17 Pages: 285-285
- DOI
  10.1186/s13075-015-0792-1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253089
[Journal Article] Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration.2015
- Author(s)
  Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N, Akimoto T, Higashi Y, Ochi M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Pages: 1257-1265
- DOI
  10.1016/j.febslet.2015.03.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253089, KAKENHI-PROJECT-25670762
[Journal Article] Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration.2015
- Author(s)
  Nakamura Y, Miyaki S, Ishitobi H, Matsuyama S, Nakasa T, Kamei N, Akimoto T, Higashi Y, Ochi M.
- Journal Title
  
  FEBS Lett
  
  Volume: 589(11) Pages: 1257-65
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24689057
[Journal Article] Exosomes from IL-1beta stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes.2014
- Author(s)
  Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, Ochi M.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 4 August Pages: 163-174
- DOI
  10.1186/ar4679
- NAID
  40020598563
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J05729, KAKENHI-PROJECT-24689057, KAKENHI-PROJECT-25253089
[Journal Article] 骨格筋損傷に対する新たな治療開発2014
- Author(s)
  亀井直輔，石川正和，中佐智幸，大川新吾，森亮，味八木茂，越智光夫
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume: 88 Pages: 230-235
- Data Source
  KAKENHI-PROJECT-25293324
[Journal Article] Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration.2014
- Author(s)
  Shinbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S, Ochi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 445 Pages: 381-387
- DOI
  10.1016/j.bbrc.2014.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592235, KAKENHI-PROJECT-24689057, KAKENHI-PROJECT-25253089
[Journal Article] Administration of microRNA-210 promotes spinal cord regeneration in mice2014
- Author(s)
  Ujigo S, Kamei N, Hadoush H, Fujioka Y, Miyaki S, Nakasa T, Tanaka N, Nakanishi K, Eguchi A, Sunagawa T, Ochi M
- Journal Title
  
  Spine
  
  Volume: 39 Pages: 1099-1107
- DOI
  10.1097/brs.0000000000000356
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293324
[Journal Article] Macroview of microRNA function in osteoarthritis.2012
- Author(s)
  Miyaki Shigeru
- Journal Title
  
  Nature Reviews Rheumatology
  
  Volume: 14 ; 8(9) Pages: 543-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689057
[Journal Article] MicroRNA-140 plays dual roles in both cartilage development and homeostasis.2010
- Author(s)
  Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H.
- Journal Title
  
  Genes Dev. 24(11)
  
  Pages: 1173-1185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] The Mohawk homeobox gene is a critical regulator of tendon differentiation2010
- Author(s)
  Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: Vol.107,No.23 Pages: 10538-10542
- DOI
  10.1073/pnas.1000525107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659278
[Journal Article] MicroRNA-140 plays dual roles both in cartilage development and homeostasis2010
- Author(s)
  Miyaki S, et al.
- Journal Title
  
  Genes & Development
  
  Volume: 24(11) Pages: 1173-1185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] MicroRNA-140 plays dual roles both in cartilage development and homeostasis2010
- Author(s)
  Miyaki S, et al.
- Journal Title
  
  Genes & development
  
  Volume: 24(11) Pages: 1173-1185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591696
[Journal Article] MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates IL-1 responses.2009
- Author(s)
  Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz MK, Asahara H.
- Journal Title
  
  Arthritis Rhuem. 60(9)
  
  Pages: 2723-2730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates IL-1 responses2009
- Author(s)
  Miyaki S, et al.
- Journal Title
  
  Arthritis and rheumatism 60(9)
  
  Pages: 2723-2730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates IL-1 responses2009
- Author(s)
  Miyaki S, et al.
- Journal Title
  
  Arthritis Rheum (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] Real-time functional imaging for monitoring miR-133 during myogenic differentiation.2009
- Author(s)
  Kato Y, Miyaki S, Yokoyama S, Omori S, Inoue A, Horiuchi M, Asahara H.
- Journal Title
  
  Int J Biochem Cell Biol. 41(11)
  
  Pages: 2225-2231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] Sox9 directily promotes Bapx1 gene expression to repress Runx2 in chondrocytes.2009
- Author(s)
  Yamashita S, Andoh M, Ueno-Kudoh H, Sato T, Miyaki S, Asahara H.
- Journal Title
  
  Exp Cell Res. 315(13)
  
  Pages: 2231-2240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] Expression of microRNA-146 in rheumatoid arthritis synovial tissue.2008
- Author(s)
  Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H.
- Journal Title
  
  Arthritis Rheum. 58(5)
  
  Pages: 1284-1292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Journal Article] MicroRNA-140 plays dual roles both in cartilage development and homeostasis
- Author(s)
  Miyaki S, et al.
- Journal Title
  
  Genes & development (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390409
[Patent] FoxO3aリン酸化阻害剤、医薬、FoxO3aリン酸化阻害用添加剤および機能性食品2015
- Inventor(s)
  松原主典、味八木茂、柴田紗知、川岡知博、谷田貝光克
- Industrial Property Rights Holder
  広島大学、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-000439
- Filing Date
  2015-01-05
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] 変形性関節症におけるmicroRNAとエピトランスクリプトーム2022
- Author(s)
  味八木　茂
- Organizer
  第34回日本軟骨代謝学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03785
[Presentation] 変形性関節症の発症におけるmiR-23a/b clusterの役割2022
- Author(s)
  藤原祐輔、味八木茂、眞田洋平、Chenyang Ding、秋本崇之、中佐智幸、石川正和、亀井直輔、安達伸生
- Organizer
  第34回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19H03785
[Presentation] 新たな細胞間コミュニケーション因子”エクソソーム”の関節疾患や組織再生への応用2021
- Author(s)
  味八木　茂
- Organizer
  第8回JAPSAM PRP・幹細胞研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03785
[Presentation] RNAプロセッシング酵素Dicerは腱の発生・成熟および損傷修復過程に関与する2021
- Author(s)
  大本武児、味八木茂、眞田洋平、中佐智幸、石川正和、亀井直輔、宿南知佐、安達伸生
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20H03805
[Presentation] 靭帯変性における神経ペプチドの発現解析2020
- Author(s)
  徳本真矢、中佐智幸、石川正和、生田祥也、味八木茂、金光宗一、白川圭子、安達伸生
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09066
[Presentation] トランスサイレチン安定化作用を持つカルノシン酸の機能解析2019
- Author(s)
  海切弘子，谷本暁, 柴田紗知，味八木茂，松原主典
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K07791
[Presentation] 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳樂慶太、真田洋平、篠原正浩、萩野浩、味八木茂
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳樂慶太、味八木茂、生田祥也、眞田洋平、篠原正浩、安達伸生、永島英樹、Lotz Martin
- Organizer
  第34回日本整形外科基礎学会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 変形性関節症マウスモデルを用いたひざ関節周囲骨の組織学的スコアリングシステムの確立2019
- Author(s)
  柳楽慶太、生田祥也、篠原正浩、中佐智幸、眞田洋平、大本武児、安達伸生、味八木茂、Martin Lotz
- Organizer
  第32回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-18KT0018
[Presentation] 変形性膝関節症におけるsubstance Pの治療効果の検討2019
- Author(s)
  白川圭子、中佐智幸、金光宗一、石川正和、眞田洋平、味八木茂、安達伸生
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09066
[Presentation] 変形性膝関節症におけるsubstance Pの軟骨・半月板での発現2018
- Author(s)
  白川圭子、中佐智幸、金光宗一、石川正和、味八木茂、安達伸生
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09066
[Presentation] Articular chondrocytes-derived EVs regulate osteoclastogenesis, but not osteogenesis2018
- Author(s)
  Sanada Y, Miyaki S, Adachi N.
- Organizer
  International Society for Extracellular Vesicles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0308
[Presentation] The advantages of minced cartilage on chondrocyte proliferation and migration compared to isolated chondrocyte in atelocollagen gel.2018
- Author(s)
  Yusuke Tsuyuguchi, Tomoyuki Nakasa, Masakazu Ishikawa, Shigeru Miyaki, Ryosuke Matsushita, Munekazu Kanemitsu, Nobuo Adachi.
- Organizer
  Othopaedic Research Society 2018 annual meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04314
[Presentation] Histological scoring system for periarticular bone changes in mouse models of osteoarthritis2018
- Author(s)
  Nagira K, Miyaki S, Ikuta Y, Lotz MK.
- Organizer
  Osteoarthritis Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] Senescence accelerated mice as a new mouse model for spontaneous osteoarthritis2018
- Author(s)
  Sanada Y, Miyaki S, Ikuta Y, Ishitobi H, Shinohara M, Nagira K, Ishikawa M, Nakasa T, Matsubara K, Lotz MK, Adachi N.
- Organizer
  Osteoarthritis Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0308
[Presentation] カルノシン酸はheme oxyganase-1を誘導し軟骨変性を抑制する2018
- Author(s)
  石飛博之,真田洋平,加藤義雄,生田祥也,柴田紗知,松原主典,安達伸生,味八木茂
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-16K21192
[Presentation] Articular chondrocytes-derived EVs regulate osteoclastogenesis, but not osteogenesis2018
- Author(s)
  Sanada Y, Miyaki S, Adachi N.
- Organizer
  International Society for Extracellular Vesicles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] Histological scoring system for periarticular bone changes in mouse models of osteoarthritis2018
- Author(s)
  Nagira K, Miyaki S, Ikuta Y, Lotz MK.
- Organizer
  Osteoarthritis Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0308
[Presentation] 細砕軟骨を用いた組織工学的治療法の有用性の検討2018
- Author(s)
  露口勇輔、中佐智幸、石川正和、松下亮介、金光宗一、味八木茂、安達伸生
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H04314
[Presentation] 半月板変性におけるvasoactive intestinal peptide(VIP)の関連2018
- Author(s)
  金光宗一、中佐智幸、白川圭子、石川正和、味八木茂、安達伸生
- Organizer
  第33回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K09066
[Presentation] Senescence accelerated mice as a new mouse model for spontaneous osteoarthritis2018
- Author(s)
  Sanada Y, Miyaki S, Ikuta Y, Ishitobi H, Shinohara M, Nagira K, Ishikawa M, Nakasa T, Matsubara K, Lotz MK, Adachi N.
- Organizer
  Osteoarthritis Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] MSC由来エクソソームによるアキレス腱修復促進効果とエクソソーム表面糖鎖解析の検証2017
- Author(s)
  林　悠太，味八木　茂，眞田　洋平，亀井　直輔，石川　正和，中佐　智幸，安達　伸生
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K15667
[Presentation] 老化促進マウスにおけるカルノシン酸の肝臓及び腎臓保護効果2017
- Author(s)
  柴田紗知,石飛博之,奥田真友美,味八木茂,萱島知子,川岡知博,松原主典
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学,ウェスティン都ホテル京都(京都府京都市東山区)
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K21192
[Presentation] 老化促進マウスにおけるカルノシン酸の肝臓及び腎臓保護効果.2017
- Author(s)
  柴田紗知, 石飛博之, 奥田真友美, 味八木茂, 萱島知子, 川岡知博, 松原主典
- Organizer
  日本農芸化学会2017年度（平成29年度）大会
- Place of Presentation
  京都（京都）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] アテロコラーゲン包埋細砕軟骨片による軟骨細胞増殖・基質産生の検討2017
- Author(s)
  露口勇輔、中佐智幸、石川正和、松下亮介、味八木茂、安達伸生
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H04314
[Presentation] Comparison of biological activities between carnosic acid and piciferic acid.2017
- Author(s)
  Shibata, S., Kayashima, T.,Ishitobi, H., Miyaki, S., Kawaoka, T., Matsubara, K.
- Organizer
  FFC’s 21st International Conference and Expo on Functional Foods
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2017-03-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] 変形性関節症におけるmicroRNAを含むエクソソーム2016
- Author(s)
  味八木茂
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島市南区）
- Year and Date
  2016-02-19
- Invited
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] OA治療標的分子としてのHO-1とmicroRNAの可能性2016
- Author(s)
  味八木茂、安達伸生
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡市博多区）
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] 間葉系幹細胞由来エクソソームは新たな組織再生因子である2016
- Author(s)
  味八木茂、古田太輔、中邑祥博、石飛博之、越智光夫
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場（大阪市北区）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] 老化促進マウスにおけるカルノシン酸の長期間経口摂取による脳機能及び運動機能への影響2016
- Author(s)
  松原主典,柴田紗知,石飛博之,味八木茂,萱島知子,川岡知博
- Organizer
  日本抗加齢学会
- Place of Presentation
  パシフィコ横浜会議センター(神奈川県横浜市西区)
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-16K21192
[Presentation] 間葉系幹細胞由来エクソソームは新たな組織再生因子である2016
- Author(s)
  味八木茂、古田太輔、中邑祥博、石飛博之、越智光夫
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪国際会議場（大阪市北区）
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] シンポジウム「OA治療標的分子としてのHO-1とmicroRNAの可能性」2016
- Author(s)
  味八木　茂
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡市博多区）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] 老化促進マウスにおけるカルノシン酸の長期間経口摂取による脳及び運動機能への影響.2016
- Author(s)
  松原主典, 柴田紗知, 石飛博之,味八木茂, 萱島知子, 川岡知博
- Organizer
  第16回日本抗加齢医学会総会
- Place of Presentation
  横浜（神奈川）
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] カルノシン酸の新規作用機構と脳機能保護効果2016
- Author(s)
  柴田紗知、石飛博之、味八木茂、萱島知子、川岡知博、松原主典
- Organizer
  日本農芸化学大会2016
- Place of Presentation
  札幌市
- Year and Date
  2016-03-30
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] 変形性関節症におけるmicroRNAを含むエクソソーム2016
- Author(s)
  味八木　茂
- Organizer
  第29回日本軟骨代謝学会
- Place of Presentation
  広島大学広仁会館（広島市南区）
- Year and Date
  2016-02-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H04959
[Presentation] OA治療標的分子としてのHO-1とmicroRNAの可能性2016
- Author(s)
  味八木　茂
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場（福岡市博多区）
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-15KK0308
[Presentation] MSC由来エクソソームによるマウスモデルの骨折治癒の促進の検討2015
- Author(s)
  古田太輔、味八木茂、石飛博之、越智光夫
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場（富山市大手町）
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] MSC由来エクソソームによるマウスモデルの骨折治癒の促進の検討2015
- Author(s)
  古田太輔、味八木茂、石飛博之、越智光夫
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] Mesenchymal stem cell-derived exosomes containing microRNAs accelerate skeletal muscle regeneration.2014
- Author(s)
  Yoshihiro Nakamura, Shigeru Miyaki, Hiroyuki Ishitobi, Tomoyuki Nakasa, Naosuke Kamei, Mitsuo Ochi
- Organizer
  International Society for Extracellular Vesicles 2014
- Place of Presentation
  Rotterdam, Nederland
- Invited
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] Administration of MicroRNA-210 Promotes Spinal Cord Regeneration2014
- Author(s)
  Satoshi Ujigo, Naosuke Kamei, Shigeru Miyaki, Tomoyuki Nakasa, Mitsuo Ochi
- Organizer
  2014 Annual Meeting of the Orthopaedic Research Society
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-25293324
[Presentation] THE ROLE OF TETRASPANIN CD9 IN PATHOGENESIS OF OSTEOARTHRITIS2014
- Author(s)
  Sumiyoshi, S. Miyaki, T. Takada, H. Ishitobi, T. Nakasa, M. Ochi
- Organizer
  Osteoarthritis Research Society, world congress 2014
- Place of Presentation
  フランス、パリ
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] Exosomes derived from mesenchymal stem cells accelerate skeletal muscle regeneration2014
- Author(s)
  Y. Nakamura, H. Ishitobi, T. Kato, T. Takada, T. Nakasa, M. Lotz, S. Miyaki, M. Ochi
- Organizer
  Orthopaedic Research Society 2014
- Place of Presentation
  アメリカ、ニューオリンズ
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] カルノシン酸による変形性関節症予防効果の検討2014
- Author(s)
  石飛博之、柴田紗知、山崎聡士、味八木茂、松原主典
- Organizer
  日本抗加齢医学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-08
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] BACH1 DEFICIENT MICE REDUCE SEVERITY OF AGE-RELATED AND EXPERIMENTAL OSTEOARTHRITIS2014
- Author(s)
  T. Takada, S. Miyaki, H. Ishitobi, T. Nakasa, M. K. Lotz2 M. Ochi
- Organizer
  Osteoarthritis Research Society, World Congress 2014
- Place of Presentation
  フランス、パリ
- Data Source
  KAKENHI-PROJECT-25670651
[Presentation] Mesenchymal stem cell-derived exosomes containing microRNAs accelerate skeletal muscle regeneration2014
- Author(s)
  Yoshihiro Nakamura, Shigeru Miyaki, Hiroyuki Ishitobi, Tomoyuki Nakasa, Naosuke Kamei, Mitsuo Ochi
- Organizer
  International Society for Extracellular Vesicles 2014
- Place of Presentation
  オランダ、ロッテルダム
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] Exosomes derived from mesenchymal stem cells accelerate skeletal muscle regeneration.2014
- Author(s)
  Y. Nakamura, H. Ishitobi, T. Kato, T. Takada, T. Nakasa, M. Lotz, S. Miyaki, M. Ochi
- Organizer
  Orthopaedic Research Society 2014
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] Bach1 deficient mice reduce severity of age-related osteoarthritis through the maintenance of autophagy and SOD22014
- Author(s)
  suyoshi Takada, Shigeru Miyaki, Hiroyuki Ishitobi, Tomoyuki Nakasa, Kazuhiko Igarashi, Martin Lotz, Mitsuo Ochi
- Organizer
  Orthopaedic Research Society 2014
- Place of Presentation
  アメリカ、ニューオリンズ
- Data Source
  KAKENHI-PROJECT-25670651
[Presentation] MicroRNA-210の関節内投与による半月板修復に対する促進効果2014
- Author(s)
  川西啓生，中佐智幸，亀井直輔，味八木茂，越智光夫
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Data Source
  KAKENHI-PROJECT-25293324
[Presentation] カルノシン酸による変形性関節症の予防効果の検討2014
- Author(s)
  石飛博之、柴田紗知、山崎聡士、味八木茂、松原主典
- Organizer
  日本体力医学会
- Place of Presentation
  長崎
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-26450159
[Presentation] Bach1ノックアウトマウスは加齢性および実験的変形性関節症の症状を軽減する2014
- Author(s)
  高田剛志、味八木茂、石飛博之、中佐智幸、中邑祥博、加藤智弘、五十嵐和彦、越智光夫
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都府医師会館（京都市中京区）
- Data Source
  KAKENHI-PROJECT-25670651
[Presentation] microRNA-210による脊髄再生2013
- Author(s)
  宇治郷諭，亀井直輔，味八木茂，中佐智幸，越智光夫
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場（千葉市美浜区）
- Data Source
  KAKENHI-PROJECT-25293324
[Presentation] MicroRNA-210の関節内投与による半月板修復に対する促進効果2013
- Author(s)
  川西啓生，中佐智幸，亀井直輔，味八木茂，越智光夫
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場（千葉市美浜区）
- Data Source
  KAKENHI-PROJECT-25293324
[Presentation] 血管新生マイクロRNAによる脊髄再生2013
- Author(s)
  宇治郷諭，亀井直輔，味八木茂，中佐智幸，越智光夫
- Organizer
  第42回日本脊椎脊髄病学会
- Place of Presentation
  沖縄コンベンションセンター（宜野湾市真志喜）
- Data Source
  KAKENHI-PROJECT-25293324
[Presentation] 変形性関節症におけるmicroRNAの役割2013
- Author(s)
  味八木　茂
- Organizer
  第28回日本整形外科基礎学術集会
- Place of Presentation
  幕張メッセ国際会議場（千葉市美浜区）
- Invited
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] Expression of miR-140 in human articular cartilage and during chondrogenesis2008
- Author(s)
  Miyaki S, et al.
- Organizer
  The 72nd annual meeting of the American College of Rheumatology and the 43nd annual meeting of the Association of Rheumatology Health Professionals
- Place of Presentation
  San Francisco, CA, USA
- Data Source
  KAKENHI-PROJECT-20390409
[Presentation] Expression of miR-140 in human articular cartilage and during chondrogenesis.2008
- Author(s)
  Miyaki S, et al.
- Organizer
  The 72nd annual meeting of the American College of Rheumatology and the 43nd annual meeting of the Association of Rheumatology Health Professionals.
- Place of Presentation
  San Francisco, CA(米国)
- Data Source
  KAKENHI-PROJECT-20390409
[Presentation] Expression of microRNA-146 in rheumatoid arthritis synobial tissue2007
- Author(s)
  Miyaki S.
- Organizer
  2007ACR/ARHP Annual Scientific Meeting
- Place of Presentation
  Boston Convention and Exhibition Center(MA, USA)
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-19659391
[Presentation] Expression of microRNA-146 in rheumatoid arthritis synobial tissue.2007
- Author(s)
  Miyaki S.
- Organizer
  2007 ACR/ARHP Annual Scientific Meeting
- Place of Presentation
  Boston Convention and Exhibition Center (MA, USA)
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-18055038
[Presentation] Expression of microRNA-146 in rheumatoid arthritis synobial tissue2007
- Author(s)
  Miyaki S.
- Organizer
  2007ACR/ARHP Annual Scientific Meeting
- Place of Presentation
  Boston Convention and Exhibition Center (MA, USA)
- Year and Date
  2007-11-09
- Data Source
  KAKENHI-PROJECT-17659480
[Presentation] Mesenchymal stem cells-derived exosomes promote bone repair in mouse model
- Author(s)
  Furuta T, Miyaki S, Ishitobi H, Kamei N, Miyado K, Ochi M
- Organizer
  Orthopaedic Research Society 2015 Annual Meeting
- Place of Presentation
  Las Vegas, U.S.A
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] テトラスパニンCD9,エクソソームと骨折治癒の検討
- Author(s)
  古田大輔、味八木茂、石飛博之、住吉範彦、越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] テトラスパニンCD9,エクソソームと骨折治癒の検討
- Author(s)
  古田大輔、味八木茂、石飛博之、住吉範彦、越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] Bach1ノックアウトマウスは加齢性および実験的変形性関節症の症状を軽減する
- Author(s)
  高田剛志、味八木茂、石飛博之、中佐智幸、五十嵐和彦、マーティン　ロッツ、越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25670651
[Presentation] microRNAを含む間葉系幹細胞由来エクソソームは骨格筋再生を促進する
- Author(s)
  中邑祥博、味八木茂、石飛博之、中佐智幸、亀井直輔、越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] THE ROLE OF TETRASPANIN CD9 IN PATHOGENESIS OF OSTEOARTHRITIS
- Author(s)
  Sumiyoshi N, Miyaki S, Takada T, Ishitobi H, Nakasa T, Ochi, M
- Organizer
  Osteoarthritis Research Society International world congress
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] IL-1刺激滑膜細胞由来エクソソームは軟骨細胞に関節症性変化を引き起こす
- Author(s)
  加藤智弘、味八木茂、石飛博之、中邑祥博、中佐智幸、マーティン　ロッツ、越智光夫
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  東京医科歯科大学（東京都文京区）
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] Mesenchymal stem cell-derived exosomes containing microRNAs accelerate skeletal muscle regeneration
- Author(s)
  Nakamura Y, Miyaki S, Ishitobi H, Nakasa T, Kamei N, Ochi M.
- Organizer
  International Society for extracellular vesicles
- Place of Presentation
  Rotterdam, The Netherlands
- Year and Date
  2014-04-30 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] THE ROLE OF TETRASPANIN CD9 IN PATHOGENESIS OF OSTEOARTHRITIS
- Author(s)
  Sumiyoshi N, Miyaki S, Takada T, Ishitobi H, Nakasa T, Ochi, M
- Organizer
  Osteoarthritis Research Society International world congress
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] 間葉系幹細胞由来のエクソソームは骨格筋再生を促進する
- Author(s)
  味八木茂、中邑祥博、石飛博之、中佐智幸、亀井直輔、越智光夫
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Invited
- Data Source
  KAKENHI-PROJECT-25253089
[Presentation] 関節炎におけるテトラスパニンCD9の役割の解析
- Author(s)
  住吉範彦、味八木茂、石飛博之、古田大輔、中佐智幸、越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24689057
[Presentation] BACH1 DEFICIENT MICE REDUCE SEVERITY OF AGE-RELATED AND EXPERIMENTAL OSTEOARTHRITIS
- Author(s)
  Takada T, Miyaki S, Ishitobi H, Nakasa T, Lotz, MK, Ochi M
- Organizer
  Osteoarthritis research society international world congress
- Place of Presentation
  Paris, France
- Year and Date
  2014-04-24 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-25670651
[Presentation] MicroRNA-210の関節内投与におる半月板損傷に対する治癒促進効果
- Author(s)
  川西啓生，中佐智幸，庄司剛士，亀井直輔，石飛博之，味八木茂，越智光夫
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島市新照院町）
- Year and Date
  2014-10-09 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-25293324

1. NAKASA Tomoyuki (60467769)

# of Collaborated Projects: 16 results

# of Collaborated Products: 38 results
2. ASAHARA Hiroshi (70294460)

# of Collaborated Projects: 9 results

# of Collaborated Products: 6 results
3. KAMEI Naosuke (70444685)

# of Collaborated Projects: 9 results

# of Collaborated Products: 14 results
4. ISHIKAWA MASAKAZU (60372158)

# of Collaborated Projects: 9 results

# of Collaborated Products: 16 results
5. ADACHI NOBUO (30294383)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
6. OCHI Mitsuo (70177244)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
7. KUDO Hiroe (20425713)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
8. 橋本徳 (80392489)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. Matsubara Kiminori (90254565)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
10. 宿南知佐 (60303905)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
11. KUBO Tadahiko (70397959)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
12. KATO Yoshio (20415657)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
13. Shoji Takeshi (50736569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. Furuta Taisuke (30781645)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 山西芳裕 (60437267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 寺村岳士 (40460901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. SATO Tempei (00571944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. ITO Yoshiaki (50511044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. SHIMOSE Shoji (30304439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. YAMASAKI Takuma (50444683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ISHITOBI Hiroyuki (30772074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
22. Shinohara Masahiro (60345733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 横山成俊 (90511080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 五十嵐ありさ (60572998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 近江雅人 (60273645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 岩見真吾 (90518119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野下浩司 (10758494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 眞田洋平 (50796117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
29. 亀井豪器 (60633039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 小野寺勇太 (30510911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 村川泰裕 (50765469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 竹原俊幸 (60580561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 池田豊 (70425734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 作田智彦 (60878289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 内部健太 (20584618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 天池一真 (00866600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 竹下潤一 (60574390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 中前稔生 (40595758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 四宮陸雄 (80581454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 酒井宏水 (70318830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. Lotz Martin

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
42. OGURA Toshihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 林悠太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 宮戸健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 東幸仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 柴田紗知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyaki Shigeru 味八木 茂

MIYAKI Shigeru 味八木 茂

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The role of chondrocyte/senescent cells-derived exosomal microRNA in pathogenesis of osteoarthritis, and in silico drug discoveryathogenesis of osteoarthritis and in silico drug discoveryPrincipal Investigator

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Miyaki Shigeru 味八木茂

MIYAKI Shigeru 味八木茂