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SASAKI Akira  佐々木 朗

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Researcher Number 00170663
Other IDs
Affiliation (Current) 2022: 岡山大学, 医歯薬学総合研究科, 特命教授
Affiliation (based on the past Project Information) *help 2022: 岡山大学, 医歯薬学総合研究科, 特命教授
2021: 岡山大学, 医歯薬学域, 教授
2016 – 2020: 岡山大学, 医歯薬学総合研究科, 教授
2018: 岡山大学, 大学院医歯薬学総合研究科, 教授
2012 – 2016: 岡山大学, 医歯(薬)学総合研究科, 教授 … More
2014: 岡山大学, 大学院医歯薬学総合研究科, 教授
2005 – 2011: OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, DENTISTRY AND PHARMACEUTICAL SCIENCES, PROFESSOR, 大学院・医歯薬学総合研究科, 教授
2002 – 2004: GRADUATE SCHOOL OF MEDICINE AND DENTISTRY, PROFESSOR, 大学院・医歯学総合研究科, 教授
2001 – 2002: Okayama University, GRADUATE SCHOOL OF MEDICINE AND DENTISTRY, ASSOCIATE PROFESSOR, 大学院・医歯学総合研究科, 助教授
2000: Okayama University, Dental School, Associate Professor, 歯学部, 助教授
1996 – 1999: 岡山大学, 歯学部・附属病院, 講師
1997 – 1998: 岡山大学, 歯学部附属病院, 講師
1995: 岡山大学, 歯学部・付属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Surgical dentistry / Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Except Principal Investigator
Surgical dentistry / Surgical dentistry / Basic Section 57060:Surgical dentistry-related / 補綴理工系歯学
Keywords
Principal Investigator
破骨細胞 / 口腔扁平上皮癌 / 骨破壊 / 骨浸潤 / 骨吸収 / 高カルシウム血症 / bone destruction / 口腔癌 / 顎骨浸潤 / 血管新生因子 … More / 血管新生阻害剤 / 血管新生 / TNP-470 / 破骨細胞性骨吸収 / 血管新生阻害薬 / 癌関連線維芽細胞 / angiogenesis inhibitor / osteoclast / bone resorption / hypercalcemia / 骨転移 / osteoclastic bone resorption / bone invasion / ビスフォスフォネート / 骨破壊モデル / angiogenin / 骨微小環境 / 分子標的治療 / angiogenesis / methionine aminopeptidase-2 / 補助療法 / 放射線治療 / FAK / mTOR / 癌骨破壊 / 高カルシウム血漿 / 癌の浸潤 / 骨代謝 / ノックダウン / 骨基質 / neomycine / 癌誘発骨破壊 / angionenin / ノックアウトマウス / 癌 / がん関連線維芽細胞 / 悪性腫瘍 / oral squamous cell carcinoma / jaw invasion / マトリックスメタロプロテアーゼ / 乳癌細胞 / ヒトメラノーマ細胞 / Matrix metalloproteinase / matrix metalloproteinase inhibitor / cancer therapy / human breast cancer / human malignant melanoma / 骨代謝性疾患 / 副甲状腺ホルモン関連蛋白 / 口腟扁平上皮癌 / 血管新生障害剤 / oral squamous cell carsinoma / bone disease / PTHrP / 結合組織成長因子 / アンチセンス / connective tissue growth factor / bone metastasis / molecular target therapy / si RNA / マイクロアレイ / 遺伝子発現 / 高カルシウム / 遺伝子 / siRNA / transfection / microarray / 骨吸収因子 / 評価モデル / TGF-β / TβRI-I / 顎骨破壊 / 骨吸収マーカー / 術前予測 / 診断マーカー / 骨浸潤評価 / osteoclasts / oral squamous carcinoma / evaluation model / transforming growth factor-β / マスト細胞 / 癌骨破壊病変 / ケミカルメディエーター / 骨破壊病変 / 骨吸収機構 / ケミカルメディエータ- / 銅キレート / Lysyl oxidase / 癌の骨転移 / 癌の骨浸潤 / 癌性骨疼痛 … More
Except Principal Investigator
口腔癌 / angiogenin / 口腔扁平上皮癌 / 血管新生 / oral cancer / oral squamous cell carcinoma / 浸潤・転移 / 浸潤 / 固形癌内部環境 / 低酸素 / 扁平上皮癌 / 癌 / Angiogenin / 骨代謝 / metastasis / bone resorption / A431 / アポトーシス / Bcl-2 / ICE / CED3 / CPP32 / doc-1 / 口腟扁平上皮癌 / invasion / MMP / 血管新生因子 / VEGF / PD-ECGF / VEGF-C / angiogenic factor / hypoxia / CDDP(シスプラチン)耐性 / グルコース飢餓 / Glucose-regulated proteins (GRPs) / JNK1 / SAPK / Caspase-3 / CDDP (Cisplatin) resistance / stress conditions in solid tumors / glucose-starved stress / RNA interference / リボソームRNA / 増殖 / angiogenesis / ribosomal RNA / 口腔癌骨浸潤 / PRL-3 / 上皮成長因子受容体 / 口腔 / 予後 / 細胞増殖 / 血管内皮前駆細胞 / 分化誘導 / 骨折 / 骨折治癒過程 / ニコチン / EGFR / リンパ管新生 / 骨転移 / 臓器特異性 / 転移因子 / 心腔内注射 / 骨吸収型骨転移 / 骨形成型骨転移 / Differental Display / 心腔齲内注射 / 転移性御意電子 / bone metastasis / metastatic marker / bone formation / molecular mechanism / molecular cloning / テロメラーゼ / 癌化学療法 / シスプラチン耐性細胞 / telomerase / cancer chemotherapy / cisplatin resistant cell / シスプラチン耐性 / シスプラチン(CDDP)耐性 / p53 / p21 / WAF-1 / Cip1 / Bax / Fas / Cisplatin (CDDP) resistance / squamous cell carcinoma / apoptosis / 遺伝子治療 / 導入効率 / 癌抑制遺伝子 / 口腟癌 / 非ウイルスベクター / アデノウイルスベクター / oral squamous cell carsinoma / gene therapy / efficacy / tumor suppressor gene / MMP阻害薬 / 同所移植 / MMP阻害剤 / 転移 / Invasion / MMP Inhibitor / Orthotopic implantation / 癌抑制遺伝子p53及びp16 / 癌抑制遺伝子p16 / 遺伝子導入 / 脱メチル化剤 / tumor suppressor gene p16 and p53 / 分子標的治療 / HIF-1α / シスプラチン(CDDP) / 低酸素環境 / stress conditions solid tumors / molecular target therapy / HIF-1 α / Cisplatin(CDDP) / Glicose-regulated proteins(GRPs) / CCDP(シスプラチン)耐性 / Apoptosis / ビスフォスフォネート / 義歯 / 骨吸収 / 組織計測 / ラット / 臼歯部口蓋骨組織 / 骨形態計測 / Bisphosphonate / denture / histomorphometry / rat / リポゾームRNA / cell proliferation / invasion・metastasis / ヌクレオチド除去修復 / DNAミスマッチ修復 / nucleotide excision repair (NER) / DNA mismatch repair (MMR) / リボソーム / 低酸素(hypoxia) / proliferation / ribosome / hvpoxia / Semaphorin 4D / 骨浸潤 / CGRP / 癌性骨痛 / 癌骨微小環境 / CGRP8-37 / 癌性骨疼痛 / 口腔癌の骨浸潤・骨転移 / 神経ペプチドCGRP / 骨破壊 / 顎骨破壊 / 破骨細胞 / ヘッジホッグ / 癌骨破壊 / Hedgehog / CCN2 / VASH1 / 内軟骨性骨化 / 軟骨 / 顎骨浸潤 / 癌性疼痛 / 骨痛 Less
  • Research Projects

    (38 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (41 People)
  •  口腔癌骨破壊病変における知覚神経と癌細胞の相互作用メカニズムの解明

    • Principal Investigator
      奥井 達雄
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Shimane University
  •  新規破骨細胞形成促進因子Angiogeninが口腔癌骨浸潤に果たす役割の解明

    • Principal Investigator
      伊原木 聰一郎
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  癌の骨破壊病変に対する銅のキレートを応用した治療戦略の構築とその制御機構の解析Principal Investigator

    • Principal Investigator
      佐々木 朗
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  PRL-3による口腔扁平上皮癌の顎骨浸潤抑制メカニズムの解明

    • Principal Investigator
      吉田 祥子
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  The role of neuropeptide CGRP and regulatory mechanism for bone destruction in bone invasion and bone metastasis of oral cancer

    • Principal Investigator
      YOSHIOKA NORIE
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University
  •  The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling

    • Principal Investigator
      SHIMO Tsuyoshi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido
  •  Role and regulatory mechanisms of Semaphorin 4D in bone invasion of oral cancer.

    • Principal Investigator
      Ibaragi Soichiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  The relationship between cancer-associted fibroblast and mast cell on the osteolysis of cancer induced bone diseasePrincipal Investigator

    • Principal Investigator
      Sasaki Akira
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis

    • Principal Investigator
      MURASE Yurika
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Function of PRL-3 in oral squamous cell carcinoma

    • Principal Investigator
      Yoshida Shoko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Role of cancer-associate fibroblasts on the regulation of angiognesis and bone resorptionPrincipal Investigator

    • Principal Investigator
      SASAKI AKIRA
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation

    • Principal Investigator
      IBARAGI Soichiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Analysis of the biological role and the expression of angiogenin in the process of fracture healing

    • Principal Investigator
      YOSHIOKA NORIE
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Development of molecular target therapy using new angiogenin inhibitor against cancer induced bone diseasesPrincipal Investigator

    • Principal Investigator
      SASAKI AKIRA
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Investigation of mechanism of angiogenesis factor, angiogenin, as a molecular target against cancer-induced bone destructionPrincipal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Angiogenin-induced differentiation of endothelial progenitor cell and the mechanism of tumor angiogenesis

    • Principal Investigator
      KISHIMOTO Koji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  癌誘発骨破壊病変の制御に立脚した血管骨代謝研究分野の創生に向けての基礎的研究Principal Investigator

    • Principal Investigator
      佐々木 朗
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  Investigation of the Mechanism of Angiogenin-Mediated Cancer Cell Proliferation and Tumor Angiogenesis, and Its Application for Cancer Treatment

    • Principal Investigator
      KISHIMOTO Koji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  The development of evaluation model of the cancer bone invasion reproducing bone microenvironment and the search of the new diagnosis marker for the cancer-induced bone resorptionPrincipal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  THE EXPRESSION OF ANGIOGENIN IN ORAL CANCER AND ITS FUNCTIONS

    • Principal Investigator
      KISHIMOTO KOJI
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMOR

    • Principal Investigator
      MESE HIROSHI
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Effect of topical administration of Bisphosphponate on bone resorption under denture base

    • Principal Investigator
      HARA Tetsuya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Investigation of mechanism of methionine aminopeptidase-2 as a molecular target against cancer-induced bone destructionPrincipal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  ANALYSIS OF APOPTOSIS INDUCED MOLECULAR TARGET THERAPY OF CISPLATIN RESISTANT TUMOR UNDER STRESS CONDITIONS

    • Principal Investigator
      MESE Hiroshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  INVESTIGATION OF HIF-1α TARGET MOLECULE THERAPY OF SOLID TUMORUNDER STRESS CONDITIONS

    • Principal Investigator
      MATSUMURA Tomohiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Investigation of mechanism of connective tissue growth factor (CTGF) as a molecular target against cancer-induced bone destructionPrincipal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  EXPERIMENTAL STUDY OF MECHANISM OF ANGIOGENESIS INHIBITOR, TNP-470 ON THE BONE METABOLISM AND CLINICAL APPROACH FOR HUMORAL HYPERCALCEMIA OF MARIGNANCY.Principal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  STUDY OF TUM0R SUPPRESSOR GENE AND ANGIOGENESIS IN ORAL CAJNCER -Effect of the transfection of p53 and p16 tumor suppressor genes on angiogenesis-.

    • Principal Investigator
      KISHIMOTO Koji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  口腔癌に特異的なTruncated EGF-Receptorの発現と治療への応用

    • Principal Investigator
      MATSUMURA Tomohiro
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  EXPERIMENTAL STUDY OF GENE THERAPY FOR ORAL CANCER USING A TUMOR SUPPRESSOR GENE DOC-1.

    • Principal Investigator
      MATSUMURA Tomohiro
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  The Experimental Research for Analysis and Treatment of Invasion of Ora Cancer. (Inhibitory effects regarding MMP production as target.)

    • Principal Investigator
      NISHIYAMA Akiyoshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  INVESTIGATION OF MECHANISM OF MATRIX METALLOPROTEINASE ON THE ROLE OF BONE METABOLISM AND CLINICAL APPOACH FOR BONE INVASION AND OSTEOLYTIC LESIONS BY CANCER IN ANIMAL MODELPrincipal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  INVESTIGATION OF MECHANISMS OF CDDP-INDUCED APOPTOSIS IN THE CDDP-RESISTANT A431 CELL LINE

    • Principal Investigator
      TAKEBAYASHI Toshiaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  INVESTIGATION OF MECHANISM OF BONE METTASTASIS AND MOLECULAR CLONING OF BONE METASITASIS RELATED GENE

    • Principal Investigator
      MATSUMURA Tomohiro
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  EXAMINATION OF TELOMERASE ACTIVITY AND TUMOR SUPPRESSOR GENE ON HUMAN ORAL CANCERS

    • Principal Investigator
      UEYAMA Yoshiya
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  INVESTIGATION OF MECHANISM OF ANGIOGENESIS INHIBITOR,TNP-470 ON THE ROLE OF BONE METABOLISM AND CLINICAL APPROACH FOR HUMAN ORAL CANTER JAW INVASION IN NUDE MICE MODEL.Principal Investigator

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY
  •  口腔癌の顎骨浸潤に対するビスフォスフォネートの応用に関する研究-放射線治療との併用効果ならびに骨への障害について-Principal Investigator

    • Principal Investigator
      佐々木 朗
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University
  •  口腔癌の顎骨浸潤の予防および治療におけるビスフォスフォネートの応用に関する研究Principal Investigator

    • Principal Investigator
      佐々木 朗
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University

All 2021 2020 2019 2018 2017 2016 2015 2014 2009 2008 2006 2005

All Journal Article Presentation

  • [Journal Article] Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment2021

    • Author(s)
      Yoshida Shoko、Shimo Tsuyoshi、Takabatake Kiyofumi、Murase Yurika、Obata Kyoichi、Okui Tatsuo、Kunisada Yuki、Ibaragi Soichiro、Nagatsuka Hitoshi、Sasaki Akira
    • Journal Title

      Diagnostics

      Volume: 11 Pages: 1044-1044

    • DOI

      10.3390/diagnostics11061044

    • NAID

      120007116755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10308, KAKENHI-PROJECT-19K19159
  • [Journal Article] Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment2021

    • Author(s)
      Shoko Yoshida, Tsuyoshi Shimo, Kiyofumi Takabatake, Yurika Murase, Kyoichi Obata, Tatsuo Okui, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki
    • Journal Title

      Diagnostics (Basel, Switzerland)

      Volume: 11 Pages: 1044-1044

    • NAID

      120007116755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Journal Article] Expression and Role of IL-1β Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing2020

    • Author(s)
      Shimo Tsuyoshi、Takebe Hiroaki、Okui Tatsuo、Kunisada Yuki、Ibaragi Soichiro、Obata Kyoichi、Kurio Naito、Shamsoon Karnoon、Fujii Saki、Hosoya Akihiro、Irie Kazuharu、Sasaki Akira、Iwamoto Masahiro
    • Journal Title

      Int.J.Mol.Sci.

      Volume: 21 Pages: 2365-2365

    • DOI

      10.3390/ijms21072365

    • NAID

      120007127458

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K17090, KAKENHI-PROJECT-18K09641, KAKENHI-PROJECT-19K10171, KAKENHI-PROJECT-18H02999
  • [Journal Article] High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer.2020

    • Author(s)
      Nakamura Tomoya、Okui Tatsuo、Hasegawa Kazuaki、Ryumon Shoji、Ibaragi Soichiro、Ono Kisho、Kunisada Yuki、Obata Kyoichi、Masui Masanori、Shimo Tsuyoshi、Sasaki Akira
    • Journal Title

      Oncology Reports

      Volume: 44 Pages: 2547-2558

    • DOI

      10.3892/or.2020.7788

    • NAID

      120007004824

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03889
  • [Journal Article] High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4.2020

    • Author(s)
      Sakamoto Yumi、Okui Tatsuo、Yoneda Toshiyuki、Ryumon Shoji、Nakamura Tomoya、Kawai Hotaka、Kunisada Yuki、Ibaragi Soichiro、Masui Masanori、Ono Kisho、Obata Kyoichi、Shimo Tsuyoshi、Sasaki Akira
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 531 Pages: 422-430

    • DOI

      10.1016/j.bbrc.2020.07.120

    • NAID

      120006890006

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-18H02999, KAKENHI-PROJECT-20H03859, KAKENHI-PROJECT-20H03889
  • [Journal Article] Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression2019

    • Author(s)
      SHIMO TSUYOSHI、KOYAMA EIKI、OKUI TATSUO、MASUI MASANORI、KUNISADA YUKI、IBARAGI SOICHIRO、YOSHIOKA NORIE、KURIO NAITO、YOSHIDA SHOKO、SASAKI AKIRA、IWAMOTO MASAHIRO
    • Journal Title

      In Vivo

      Volume: 33 Pages: 85-91

    • DOI

      10.21873/invivo.11443

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02999
  • [Journal Article] Feasibility of the new TNM classification on the evaluation of progression degree of tongue squamous cell carcinomas:2019

    • Author(s)
      Yoshida Shoko、Kishimoto Koji、Murase Yurika、Ibaragi Soichiro、Yoshioka Norie、Okui Tatsuo、Nagatsuka Hitoshi、Sasaki Akira
    • Journal Title

      J Jpn Soc Oral Oncology

      Volume: 31 Issue: 3 Pages: 151-156

    • DOI

      10.5843/jsot.31.151

    • NAID

      130007710118

    • ISSN
      0915-5988, 1884-4995
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10308
  • [Journal Article] Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma2019

    • Author(s)
      Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.
    • Journal Title

      Int J Oncol.

      Volume: 54(1) Pages: 283-294

    • DOI

      10.3892/ijo.2018.4631

    • NAID

      120006786204

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K11836, KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-15K20853, KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-16K20577
  • [Journal Article] Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma2019

    • Author(s)
      Ryumon S., Okui T.,Kunisada Y., Kishimoto K., Shimo T., Hasegawa K., Ibaragi S., Akiyama K., Thi Thu Ha N., Hassan NMM., Sasaki A.
    • Journal Title

      Oncology Reports

      Volume: 42 Pages: 2611-2621

    • DOI

      10.3892/or.2019.7367

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04405, KAKENHI-PROJECT-18H02999
  • [Journal Article] The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma2018

    • Author(s)
      Shoko Yoshida, Tsuyoshi Shimo, Yurika Murase, KiyoFumi Takabatake, Koji Kishimoto, Soichiro Ibaragi, Norie Yoshioka, Tatsuo Okui, Hitoshi Nagatsuka AND Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 38 Pages: 955-962

    • DOI

      10.21873/anticanres.12309

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K20579, KAKENHI-PROJECT-16H06992, KAKENHI-PROJECT-16K20577
  • [Journal Article] Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma2017

    • Author(s)
      Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.
    • Journal Title

      International journal of oncology

      Volume: 51 Pages: 625-32

    • DOI

      10.3892/ijo.2017.4050

    • NAID

      120006370695

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11836, KAKENHI-PROJECT-16K20577, KAKENHI-PROJECT-16H06992
  • [Journal Article] Expression and Roles of CCN2 in Dental Epithelial Cells2015

    • Author(s)
      Shimo T, Koyama E, Kurio N, Matsumoto K, Okui T, Ibaragi S, Yoshioka N, Sasaki A.
    • Journal Title

      In Vivo

      Volume: 29 Pages: 189-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26463004
  • [Journal Article] Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation2014

    • Author(s)
      Koji Kishimoto, Shoko Yoshida, Soichiro Ibaragi, Norie Yoshioka, Guo-Fu Hu, Akira Sasaki
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 2113-2122

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24778013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390463
  • [Journal Article] Neamine Inhibits Oral Cancer Progression by Suppressing Angiogenin-mediated Angiogenesis and Cancer Cell Proliferation」2014

    • Author(s)
      Kishimoto K Yoshida S, Ibaragi S, Yoshioka N, Hu GF, Sasaki A.
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 2113-21

    • Data Source
      KAKENHI-PROJECT-26463004
  • [Journal Article] Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.2014

    • Author(s)
      Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 22 Pages: 5338-44

    • Data Source
      KAKENHI-PROJECT-26463004
  • [Journal Article] Pathogenic role of Connective Tissue Growth Factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.2006

    • Author(s)
      Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A, Takigawa M
    • Journal Title

      Journal of Bone and Mineral Research 21

      Pages: 1045-1059

    • Data Source
      KAKENHI-PROJECT-17390536
  • [Journal Article] 義歯床下骨組織の吸収に対するBisphosphonate局所投与の影響2005

    • Author(s)
      花田俊士, 原 哲也, 島津千恵, 佐々木朗, 皆木省吾
    • Journal Title

      日本補綴歯科学会雑誌 49巻・114回特別号(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15592051
  • [Presentation] 舌扁平上皮癌の進行度評価における第8版TNM分類の実用性 第2報 -正誤表に準拠-2019

    • Author(s)
      吉田祥子,岸本晃治,村瀬友里香,奥井達雄,吉岡徳枝,伊原木聰一郎,長塚 仁,佐々木 朗
    • Organizer
      第64回日本口腔外科学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-19K10308
  • [Presentation] 癌骨微量環境における神経ペプチドCGRPの役割に関する検討2019

    • Author(s)
      坂本裕美,吉岡德枝,奥井達雄,竜門省二,伊原木聰一郎,佐々木 朗
    • Organizer
      第64回(公社)日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K09811
  • [Presentation] CCN2-VASH1-SOD2 axisを介した内軟骨性骨化調節機構2018

    • Author(s)
      村瀬友里香,青山絵理子,鈴木康弘,佐々木 朗,久保田 聡,佐藤靖史,滝川正春
    • Organizer
      第31回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-17H06885
  • [Presentation] CCN2-VASH1-SOD2 axisによる軟骨細胞終末分化における細胞死の制御2018

    • Author(s)
      村瀬友里香,青山絵理子,鈴木康弘,佐々木 朗,久保田 聡,佐藤靖史,滝川正春
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17H06885
  • [Presentation] 内軟骨性骨化過程におけるvasohibin-1 (VASH1)の発現とその意義2017

    • Author(s)
      村瀬友里香,吉田祥子,佐々木 朗
    • Organizer
      第62回(公社)日本口腔外科学会総会
    • Data Source
      KAKENHI-PROJECT-17H06885
  • [Presentation] Expression of vasohibin-1 (VASH1) during endochondral ossification and its significance2017

    • Author(s)
      村瀬友里香,青山絵理子,鈴木康弘,佐々木 朗,久保田 聡,佐藤靖史,滝川正春
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17H06885
  • [Presentation] Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation2017

    • Author(s)
      Soichiro Ibaragi; Shinichi Kodama; Daisuke Kuwajima; Tatsuo Okui; Norie Yoshioka; Tsuyoshi Shimo; Akira Sasaki
    • Organizer
      6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO)
    • Place of Presentation
      インド
    • Year and Date
      2017-05-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26463004
  • [Presentation] Vasohibin-1 (VASH1)による内軟骨性骨化の制御とCCN2の関与2017

    • Author(s)
      村瀬友里香,青山絵理子,久保田 聡,佐々木 朗,滝川正春
    • Organizer
      第35回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-17H06885
  • [Presentation] 口腔扁平上皮癌におけるPhosphatase of Regenerating Liver-3 (PRL-3)の臨床病理学的意義2017

    • Author(s)
      村瀬友里香、吉田祥子、Nur Mohammad Monsur Hassan、岸本晃治、長塚 仁、佐々木 朗
    • Organizer
      第36回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2017-01-26
    • Data Source
      KAKENHI-PROJECT-16K20579
  • [Presentation] 口腔癌細胞におけるニコチンと上皮成長因子受容体の関連性について2016

    • Author(s)
      桑島大介,伊原木聰一郎,高畠清文,吉岡徳枝,岸本晃治,志茂 剛,長塚 仁,佐々木 朗
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Data Source
      KAKENHI-PROJECT-26463004
  • [Presentation] 口腔癌細胞におけるニコチンと上皮成長因子受容体の関連性について2016

    • Author(s)
      桑島大介,伊原木聰一郎,高畠清文,吉岡徳枝,岸本晃治,志茂 剛,長塚 仁,佐々木 朗
    • Organizer
      第70回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-04-16
    • Data Source
      KAKENHI-PROJECT-26463004
  • [Presentation] Mammalian Target of Rapamycin Inhibitor Ternsirolimus Inhibits Human Oral Squamous Cell Carcinoma Induced Osteolysis.2009

    • Author(s)
      Tatsuo Okui, Tsuyoshi Shino. Naito Kurio, Munenori Takaoka, Norie Yoshioka. Nut Mohammad, Monsur Hassan, Yoshio Naomoto, Akira Sasaki
    • Organizer
      第2回高度医療都市を創出する未来技術国際シンポジウム 創薬パイライン : 抗がん剤・抗感染症薬の合成と評価系.
    • Place of Presentation
      岡山
    • Year and Date
      2009-02-05
    • Data Source
      KAKENHI-PROJECT-19659529
  • [Presentation] Anti-osteoclastogenic Effects of Novel Focal Adhesion Kinase Inhibitor TAE226 in Osteolytic Metastasis of Breast Cancer2009

    • Author(s)
      Naito Kurio, Tsuyoshi Shino, Munenori Takaoka. Tatsuo Okui, Norie Yoshioka, Nur Mohaimmad, Monsur Hassan, Shinji Hatakeyama, Yoshio Naomoto, Akira Sasaki
    • Organizer
      第2回高度医療都市を創出する未来技術国際シンポジウム 創薬パイライン : 抗がん剤・抗感染症薬の合成と評価系.
    • Place of Presentation
      岡山
    • Year and Date
      2009-02-05
    • Data Source
      KAKENHI-PROJECT-19659529
  • [Presentation] Mammalian target of rapamycin (mTOR)シグナルの口腔癌骨破壊における関与2008

    • Author(s)
      奥井達雄, 志茂 剛, 栗尾奈愛, 小野亜希子, 吉岡徳枝, 山本大介, 目瀬浩, 佐々木朗
    • Organizer
      第29回岡山歯学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-24
    • Data Source
      KAKENHI-PROJECT-19659529
  • [Presentation] Focal adhesion kinase (FAK)を分子標的とした癌骨転移制御2008

    • Author(s)
      栗尾奈愛, 志茂 剛, 奥井達雄, 吉岡徳枝, 山本大介, 佐々木朗
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-19659529
  • [Presentation] 新規FAR分子標的治療薬TAE226の癌骨破壊病変に与える効果.2008

    • Author(s)
      栗尾奈愛, 志茂 剛, 奥井達雄, 吉岡徳枝, 山本大介, 佐々木朗
    • Organizer
      第53回日本口腔外科学会総会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-19659529
  • [Presentation] 癌の骨浸潤・骨破壊におけるFocal adhesion kinase (FAK)の役割とシグナル制御.2008

    • Author(s)
      栗尾奈愛, 志茂 剛, 奥井達雄, 吉岡徳枝, 小野亜希子, 山本大介, 佐々木朗
    • Organizer
      第29回岡山歯学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-24
    • Data Source
      KAKENHI-PROJECT-19659529
  • 1.  SHIMO Tsuyoshi (40362991)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 11 results
  • 2.  KISHIMOTO Koji (40243480)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 4 results
  • 3.  YOSHIOKA Norie (50362984)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 8 results
  • 4.  IBARAGI Souitiro (80549866)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 12 results
  • 5.  MESE Hiroshi (40325098)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 6.  奥井 達雄 (40610928)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 9 results
  • 7.  MATSUMURA Tomohiro (00028747)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 8.  TAKIGAWA Masaharu (20112063)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 9.  YOSHIDA Shoko (00616047)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 8 results
  • 10.  OHYAMA Kazuhiko (20169080)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  MURASE Yurika (70803708)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 12.  NAKANISHI Toru (30243463)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  AOYAMA Eriko (10432650)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 14.  KUBOTA Satoshi (90221936)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 15.  増井 正典 (80881143)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  UEYAMA Yoshiya (00168668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TAKEBAYASHI Toshiaki (90179664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  NISHIYAMA Akiyoshi (50189320)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  HARA Tetsuya (60238160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  KINUTA Yoshihiro (50314696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MINAGI Shogo (80190693)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  SATO Yasufumi (50178779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 23.  SUZUKI Yasuhiro (60332277)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 24.  HATTORI Takako (00228488)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  新谷 悟 (80294429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  國定 勇希 (10779416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 27.  長塚 仁 (70237535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 28.  高畠 清文 (70736537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 29.  小野 喜章 (30845384)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 30.  米田 俊之 (80142313)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 31.  MORISAWA Ayaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  KUSAKA Masami
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  Hassan Mohammad Monsur
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  Hu Guo-Fu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 35.  EGUCHI Takanori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 36.  建部 廣明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  細矢 明宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  入江 一元
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  河合 穂高
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 40.  西岡 貴志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  岡元 邦彰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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