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TAKIGAWA Masaharu  滝川 正春

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Researcher Number 20112063
Other IDs
External Links
Affiliation (Current) 2022: 岡山大学, 医歯薬学域, 教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 岡山大学, 医歯薬学域, 教授
2016 – 2020: 岡山大学, 医歯薬学総合研究科, 教授
2015: 岡山大学, 大学院医歯薬学総合研究科, 教授
2011 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授
2013: 岡山大学, 医歯薬学総合研究科, 教授 … More
2013: 岡山大学, 大学院医歯薬学総合研究科, 教授
2004 – 2012: Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, professor, 大学院・医歯薬学総合研究科, 教授
2008: 岡山大学, 医歯薬学総合研究科, 教授
2008: 岡山大学, 大学院医歯薬学総合研究科, 教授
2005 – 2006: 岡山大学, 大学院医歯薬学総合研究科, 教授
2001 – 2004: Okayama University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授
1994 – 2000: 岡山大学, 歯学部, 教授
1997: Okayama Univ.Dental School, Professor, 歯学部, 助手
1991 – 1992: 大阪大学, 歯学部, 助教授
1986 – 1990: 大阪大学, 歯学部, 講師
1986: 阪大, 歯学部, 講師
1985: 大阪大学, 歯, 講師 Less
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Functional basic dentistry / General medical chemistry / Oral Science and related fields / Basic Section 57010:Oral biological science-related / Medium-sized Section 57:Oral science and related fields
Except Principal Investigator
Functional basic dentistry / 補綴理工系歯学 / Functional basic dentistry / 補綴理工系歯学 … More / Basic Section 57010:Oral biological science-related / Surgical dentistry / Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Medium-sized Section 57:Oral science and related fields / Functional basic dentistry / Prosthetic dentistry / Orthopaedic surgery / Orthopaedic surgery / 矯正・小児・社会系歯学 / Prosthodontics/ Dental materials science and / Orthodontics/Pediatric dentistry / Oral Science and related fields / Basic Section 57030:Conservative dentistry-related / Basic Section 57050:Prosthodontics-related Less
Keywords
Principal Investigator
軟骨細胞 / 軟骨 / CTGF / 細胞分化 / CCN2 / 遺伝子発現 / CCNファミリー / 骨芽細胞 / 細胞増殖 / CCN2/CTGF … More / 骨 / 結合組織成長因子 / エコジェニン / CCN3/Nov / 再生 / chondrocytes / 血管内皮細胞 / 分化 / 結合分子 / 破骨細胞 / トランスジェニックマウス / CCN family / プロテオグリカン / connective tissue growth factor (CTGF) / 受容体 / 樹立細胞株 / CCNタンパク質 / アデノウイルスベクター / 増殖 / 結合組織成長因子(CTGF) / 低酸素 / 骨折治癒 / CCN3 / Nov / シグナル伝達 / アグリカン / RANK / 内軟骨性骨化 / cartilage / 変異動物 / 変形性関節症 / OPG / 半月板 / 軟骨細胞株 / 軟骨肉腫細胞株 / コラーゲン / アルカリホスファタ-ゼ / Collagen / 遺伝子クローニング / ニューロトロフィン / Cell differentiation / 結合組織増殖因子(CTGF) / HCS-2 / osteoblasts / endothelial cells / differentiation / 血管 / trk / 神経栄養因子 / 情報伝達 / ecogenin / 血管新生 / ELISA / cbfal / mutant animal / 軟骨培養細胞株 / S-アデノシルメチオニン / ポリアミン / 遺伝子導入 / 遺伝子治療 / 顎関節 / 関節 / トランスフォーミング増殖因子 / インスリン様成長因子 / 歯根膜線維芽細胞 / 歯周組織 / シスエレメント / 組み換え体タンパク質 / MMPs / CCN1 / Cry61 / CCN4 / WISP1 / RNAi / Cyr61 / シグナルコンダクター / 分子間相互作用 / ハルミン / FGF2 / DC-STAMP / GAPDH / FGF受容体 / 歯肉線維芽細胞 / ニコチン / BMP-2 / ノックアウトマウス / MMP-3 / 転写因子 / cofactor / NuMAP / マトリックス金属プロテアーゼ3 / MMP3 / CCNファミリー2 / 細胞外マトリックス / LRP-1 / protein transport / transcytosis / トランスサートーシス / タンパク質輸送 / 骨格異常 / CTGF?CCN2 / トランスサイトーシス / 輸送 / CCN ファミリー / マスターマインド / 組織再生 / FGFR2 / decoy receptor / osteoprotegerin (OPG) / PDGFRL / signaling / osteoclasts / デコイ受容体 / 血小板 / CD302 / CCN / 癌遺伝子 / 成長因子 / アスコルビン酸 / レセプタ- / Cartilage Cell Line / Chondrosarcoma Cell Line / Cell Differentiation / Aggrecan / Oncogene / Gene Expression / Growth Factor / 軟骨特異的遺伝子 / ディフェレンシャル・ディスプレイ / 結合組織増殖因子 / 分化マーカー / Chondrocyte / Cartilage-specific gene / Differential-display / Molecular cloning / Connective tissue growth factor / Chondrosarcoma cell line / Proliferation / 8細胞 / レセプター / リコンビナントCTGF / 神経細胞 / アンチセンスオリゴマー / endochondral ossification / growth / gene expression / 神経 / オステオ(コンドロ)ニューロトロフィン / コンドロニューロトロフィン / 8 / bone / cargilage / nerve / blood vessel / neurotrophin / osteo (chondro) neurotrophin / マトリクリン / リン酸化 / MAPK / ELK / growth factor / proliferation / matricrine / receptor / phosphorylation / 抗CTGF / 転移 / 慢性関節リウマチ / 心筋梗塞 / 抗CTGF抗体 / angiogenesis / anti-CTGF antibody / metastasis / rheumatoid arthritis / neovascularization / myocardial infarction / 血管新生(病) / angiogenesis(diseases) / hypoxia / 歯 / cbfa1 / 成長 / アクチン / パールカン / hone / tooth / development / リジェネリン / 硬組織 / 遺伝子発現制御 / 遺伝子変異動物 / 間葉系幹細胞 / 歯根膜 / 結合蛋白 / CCN22 / 骨髄間葉系幹細胞 / CTGF遺伝子ノックアウトマウス / ゼラチンハイドロゲル / regeneration / regenerin / hard tissue / binding molecule / regulation of gene expression / signal transduction / 副甲状腺ホルモン / 生物学的検定法 / オルニチン脱炭酸酵素 / サイクリックAMP / 軟骨培養細胞 / Parathyoid Hormone / Bioassay / Otnithine Devatboxylase / Cyclic AMP / Cultured Chondcocyted / 軟骨由来抗腫瘍因子(CATF) / 培養軟骨細胞 / 増殖阻害因子 / 血管誘導阻害因子 / Crtilage-derived Anti-tucmor (CATF) / Cultured Chondrocytes / Established Cell Line / Endothelial Cell / Growth Inhibitor / コラ-ゲン / 軟骨肉腫 / 石灰化 / アルカリホスファターゼ / Established cell line / Chondrocytes / Osteoblasts / Proteoglycan / Chondrosarcoma / Calcification / Alkaline phosphatase / モジュール / LIPUS / Vasohibin 1 / CC3/Nov / がん / ニュートリゲノミクス / 代謝 / 糖質 / アミノ酸 / メチルグリオキサール / メラトニン / 成長板 / 解糖系 / セロトニン / 関節軟骨 / 栄養 / 細胞内機能 / 核移行 / 細胞外ベジクル / イントラクリン / 細胞外情報ネットワーク / 細胞外小胞 / 神経-筋接合部 / LRP4 / Rab14 / 結合因子 / エクソソーム / 立体構造 / 解糖 / 分化機能 / 細胞生存 / コンドロニュートリゲノミクス / ニュートリジェネティクス / GDF5 … More
Except Principal Investigator
CTGF / 軟骨細胞 / CCN2 / chondrocyte / CCN2/CTGF / 細胞増殖 / アデノウイルスベクター / 変形性関節症 / 結合組織成長因子 / 軟骨 / 骨芽細胞 / 細胞分化 / 象牙芽細胞 / チタン / CCN family / osteoclast / 遺伝子導入 / connective tissue growth factor / アポトーシス / 一次繊毛 / プロテオグリカン / CCN3 / 血管新生 / 間葉系幹細胞 / オッセオインテグレーション / 遺伝子発現 / 骨再生 / 軟骨再生 / 口腔生化学 / 内軟骨性骨形成 / トランスジェニックマウス / 内軟骨性骨化 / CTGF/CCN2 / cartilage / in situ hybridization / adenovirus vector / odontoblast / ハイドロキシアパタイト / 細胞接着 / 破骨細胞 / 象牙芽前駆細胞 / IFT88 / lncRNA / LacZ遺伝子 / CTGF遺伝子 / MC3T3-E1細胞 / モジュール / 血管内皮細胞 / 線維化 / 再生医療 / 骨髄間葉系幹細胞 / Sox9 / 血管侵入 / 骨髄 / 破骨細胞形成 / RANKL / CCNファミリー / 再生 / 骨細胞 / 分化 / 培養軟骨細胞 / chondrocytes / 軟骨肉腫 / RT-PCR / RNase Protection Assay / 遺伝子治療 / in vivo / drug delivery system / 骨転移 / 口腔癌 / bone metastasis / differential display / 結合組織成長因子(CTGF) / MAPキナーゼ / crosslink / MAP kinase / マトリックスメタロプロテアーゼ / Chondrocyte / subtractive hybridization / 修復象牙質 / アデノウイルス / β型形質転換増殖因子 / reparative dentin / MC3T3-E1 cell / Titanium / 変形性顎関節症 / メカニカルストレス / 軟骨破壊 / 一酸化窒素 / Osteoarthritis / ATDC5 / caspase / 骨破壊 / differentiation / bone marrow cells / bone regeneration / ccn2 / ELISA / hydroxyapatite / xab-2 / sod-1 / actin / RUNX2 / skeletal development / TGF-β / アテロコラーゲン / ポリ乳酸 / MC3T3E1細胞 / 顎関節症 / 遺伝子多型(SNP) / MMP-3 / IV型コラーゲン / DNA / CCN3/nov / 細胞外マトリックス / 低出力超音波パルス / ルブリシン / 修復・再生 / CCN3/Nov / 発現誘導 / テネイシン / 軟骨形成 / 誘導性発現 / ドメイン / 組み換え体タンパク質 / CAM / 管腔形成 / 遊走 / 組換え体タンパク質 / 徐放性 / 線維芽細胞 / 発現プロファイル / テロメラーゼ / DNAチップ / 脂肪細胞 / 再生治療 / インプラント / 表面粗さ / 表面性状 / 歯胚再生 / 上皮間葉相互作用 / 発生・分化 / マスターキー遺伝子 / 幹細胞 / 器官原基法 / ES細胞 / 耳介軟骨 / 組織再生 / 細胞移植 / ゲノム医化学 / 細胞医化学 / miRNA / miR-18 / Bacterial artificial chromosome(BAC)DNA / トランスジェニックマウストランスジェニックマウス / X型コラーゲンプロモーター / 肥大化軟骨細胞層 / VEGF / bacterial artificial chromosome(BAC)DNA / 10型コラーゲンプロモーター / 肥大化軟骨組織 / vegf / BAC recombination / X型コラーゲン / 肥大軟骨層 / 大腸菌内相同組換え / bacterial artificial chromosome (BAC) / 付着歯肉 / 遊離歯肉 / 上皮細胞 / 間葉細胞 / GST-RANKL / CCN2欠損マウス / 骨吸収活性 / fetal liver cells / DC-STAMP / retrovirus / CCN2産生過剰マウス / fetal liver cell / TRAP染色 / CTGF欠損マウス / M-CSF / RAW264.7細胞 / ユビキチン / プロテオミクス解析 / 神経疾患 / ユビキチンリガーゼ / 細胞生物学 / 再生医工学 / aptamer / peptide / アプタマー / ペプチド / 再生歯 / RANK / OPG / RAW264. 7 / SPR / MAPK / RAW264.7 / RANK/RANKL/OPG / メタボローム解析 / C2C12細胞 / 骨格筋分化 / 異所性骨化 / BMP2 / Ccn2欠損筋芽細胞 / 筋芽細胞の増殖 / 筋芽細胞の分化 / 筋肉内異所性骨化 / マウス筋芽細胞 / 筋管形成 / 骨芽細胞様変化 / CCN2/結合組織成長因子 / 炎症性シグナル / fibrosis / osteoarthritis / NOV / 骨 / 橋渡し研究 / NOV/CCN3 / 間葉系細胞 / 軟骨分化 / 高密度培養系 / SFRP5 / 関節変性 / Col2a1 promoter / 骨細胞様細胞 / タモキシフェン誘導性Ccn2欠損マウス / 3次元培養 / 老齢期のタモキシフェン誘導性CCN2欠損マウス / NFATc1 / カテプシンK / 初代骨細胞様細胞 / 薬剤誘導性Ccn2欠損マウス / マウス骨細胞株MLO-Y4 / 1α,25【(OH)_2】【D_3】 / 24,25【(OH)_2】【D_3】 / DNA合成 / グリコサミノグリカン合成 / 副甲状腺ホルモン / 受容体 / 培養細胞 / 樹立細胞株 / 成長因子 / 分化修飾因子 / インスリン様成長因子 / ビタミンA / Parathyroid hormone / cultured cells / receptors / established cell line / cell differentiation / growth factors / differentiation factors / Insulin-like growth factor-ll / Insulin-like growth factor-l / 転写プロモーター / Insulin-like growth factor-II / Insulim-like growth factor-I / 軟骨様細胞 / 転写調節 / Insulin-like growth factor-I / Insulin-like growth factor II / Insulin-like growth factor I / Osteoblastic cell / Chondrosarcoma / Chondrocytes / Transcriptional promoter / IGF-2遺伝子 / インプリンティング / 転写制御 / 転写制御因子 / インブリンティング / chondrosarcoma / transcriptonal regulation / imprinting / IGF-2 gene / transcriptional regulator / モルモット / TGF-β1 / 関節 / アデノウイルスペクター / LacZ / プロモーター / gene therapy / guinea pig / TGF-betaI / joint / 口腔扁平上皮癌 / 臓器特異性 / 転移因子 / 心腔内注射 / 骨吸収型骨転移 / 骨形成型骨転移 / Differental Display / 心腔齲内注射 / 転移性御意電子 / metastasis / metastatic marker / bone resorption / bone formation / molecular mechanism / oral squamous cell carcinoma / molecular cloning / クロスリンク / アフィニティークロマト / インテグリン / チロシンキナーゼ / レセプター / ペプチドマッピング / 結合組織増殖因子(CTGF) / Scatchard解析 / PDGF / FGF / connective tissue growth factor (CTGF) / affinity chromatography / proteoglycan / integrin / tyrosine kinase / 軟骨破壊因子 / 周期的機械的負荷 / マトリックスメタロプロテナーゼ / インターロイキン1 / インターロイキン-1 / 機械的負荷 / 周期的負荷 / Cartilage Degradation Factors / Cyclic Mechanical Stress / Matrix Metalloproteinases / Interleukin-1 / Proteoglycan / subtractive hybridization法 / 歯質保全療法 / dental pulp / LacZ gene / 非翻訳領域 / シスエレメント / gene expression / untranslated region / cis-element / 炎症 / クローニング / gene transfection / transforming growth factor-beta / 抜歯創 / ex vivo遺伝子導入法 / MC3T3-El cell / 抜歯創時癒過程 / BMP遺伝子 / TGF-β遺伝子 / Adenovirus vector / Tooth extraction socket / Ex vivo gene delivery / 関節軟骨 / 動物モデル / 組織変化 / Mechanical stress / Articular cartilage / Gene therapy / Adenovirus / マイクロアレイ / ケモカイン / 慢性関節リウマチ / caspase-9 / DNA発現アレイ / HSP47 / microarray / chemokine / osteosrthritis / rheumatoid arthritis / transgenic mice / 細胞周期 / M期 / チェックポイント / cell cycle / M phase / checkpoint / 破骨細胞性骨吸収 / 高カルシウム血症 / 骨浸潤 / 分子標的治療 / アンチセンス / osteoclastic bone resorption / hypercalcemia / bone invasion / bone destruction / molecular target therapy / angiogenesis / レーザーマイクロダイセクション / in situハイブリダイゼーション / 新生仔マウス下顎頭軟骨 / 未固定非脱灰切片 / collagen type I / collagen type II / collagen type IX / 新生児マウス下顎頭軟骨 / ラット顎頭骨折 / Sox-9 / laser microdissection / regeneration / 骨髄幹細胞 / 歯周組織・歯槽骨再生 / 生態親和性材料 / bFGF / 生体親和性材料 / βTCPフォーム / hydroxyapatito / シグナル伝達 / signal transduction / module / 軟骨修復 / NO / Mechanical Stress / Gene Therapy / Articular Cartilage / Cartilage Degradation / Apoptosis / Nitric Oxide / 象牙質再生 / 生体材料 / 塩基性線維芽細胞増殖因子 / 象牙質形成 / dentin regeneration / biomaterial / basic fibroblast growth factor / transforming growth factor-β / 培養骨芽細胞 / galectin-1 / デンタルインプラント / チタン特異的遺伝子 / 骨組織再生 / 幹葉系幹細胞 / Osteoblasts / Osseointegration / galection-1 / 多分化能 / 再生工学 / 細胞遊走能 / mesenchymal stem cell / multilineage differentiation / tissue engineering / cell attachment / cell proliferation / 血球 / CCN / bone marrow / hematopoiesis / アクチンリング / CD302/DCL-1 / 骨吸収 / actin ring / CCN 2/CTGF / 歯科補綴 / 接着歯学 / CAD/CAMブロック / 電子顕微鏡 / サンドブラスト / シランカップリング / 合着 / レジンセメント / ハイブリッドレジンブロック / フィラー / プライマー / CAD/CAM / レジンブロック / シランカップリング材 / 鎖骨頭蓋異形成症 / 免疫抑制剤 / ステロイド / デキサメタゾン / DEX / b-グリセロリン酸 / CCN4 / CCN5 / b-グリセロスリン酸 / 古典的Wntシグナル / CCN4, 5 / beta-グリセロフォスフェイト / Rab14 / 骨組織 / 細胞内輸送 / 骨代謝 / 細胞外基質 / 肺線維症 / angiotensin II / osteoathritis / 肥満 / AT1R / AT2R / 局所性RAS / Angiotensin II / Agtr1 / ゲノム編集 / ロサルタン / 軟骨変性 / アンジオテンシンII / CCN2コンディショナルノックアウトマウス / 変形性膝関節症 / 解糖系 / エネルギー代謝 / ワールブルグ効果 / Warburg effect / glycolysis / carcinogenesis / tooth formation / 歯の形成 / 癌 / 顎骨破壊 / ヘッジホッグ / 癌骨破壊 / Hedgehog / VASH1 / CD302 / 細胞死 / osteoblast / SHP2 / C type lectin receptor / 細胞極性 / antisense RNA / gene regulation / アンチセンスRNA / 骨格形成 / 線維化疾患 / イントラクリン作用 / PU.1 / 筋線維芽細胞 / 線維症 / 筋線維芽細胞分化 / 核内移行 / UCA1 / skeletogenesis / anti-sense RNA / S-adenosylmethionine / polyamine / LLPS / 軟骨ホメオスタシス / 非コードRNA / 変性メカニズム / reprogramming / iPS cell / transcription factor / master gene Less

  • Research Projects

    (90 results)

  • Research Products

    (1,238 results)

  • Co-Researchers

    (118 People)

  •  S-アデノシルメチオニンによる軟骨基質産生の新制御機構の解明―ポリアミンを中心に

    • Principal Investigator
      青山 絵理子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Okayama University

  •  象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用

    • Principal Investigator
      高江洲 かずみ (河田かずみ)
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57050:Prosthodontics-related
    • Research Institution
      Okayama University

  •  非コードRNAを介した新たな軟骨ホメオスタシスとその変性メカニズムの解明

    • Principal Investigator
      森谷 徳文
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kobe Tokiwa Junior College

  •  Regulation of skeletogenesis by long noncoding RNAs through CCN2

    • Principal Investigator
      久保田 聡
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Okayama University

  •  Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation

    • Principal Investigator
      久保田 聡
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Okayama University

  •  CCN２の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明

    • Principal Investigator
      西田 崇
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Okayama University

  •  Pioneering chondroneutrigenomics research and its development into chondroneutrigeneticsPrincipal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Okayama University

  •  CD302の新機能：破骨細胞の分化制御とその機構及び骨・軟骨代謝研究への展開

    • Principal Investigator
      青山 絵理子
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Okayama University

  •  細胞アンテナによる象牙質再生への道を拓く基礎研究

    • Principal Investigator
      高江洲 かずみ (河田かずみ)
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57030:Conservative dentistry-related
    • Research Institution
      Okayama University

  •  Regulation of CCN2 by an endogenous UTR blocker and its biological significance

    • Principal Investigator
      Kubota Satoshi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Okayama University

  •  Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular basePrincipal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Okayama University

  •  Analysis of mechanism of regulation of CTGF/CCN2 by RUNX2 in tooth formation

    • Principal Investigator
      MORITANI NORIFUMI
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Okayama University

  •  The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling

    • Principal Investigator
      SHIMO Tsuyoshi
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Health Sciences University of Hokkaido

  •  Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2

    • Principal Investigator
      Nishida Takashi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  New potential of CCN2: Functional evaluation as a Warburg effector

    • Principal Investigator
      Kubota Satoshi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Oral Science and related fields
    • Research Institution
      Okayama University

  •  Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regenerationPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      Oral Science and related fields
    • Research Institution
      Okayama University

  •  Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis

    • Principal Investigator
      MURASE Yurika
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University

  •  The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors

    • Principal Investigator
      Takaesu Kazumi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Roles of CCN2 and Rab14 in the formation of extracellular matrix

    • Principal Investigator
      Hoshijima Mitsuhiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontics/Pediatric dentistry
    • Research Institution
      Okayama University

  •  Mechanism and expression of CD302 as a new regulator of osteoclast maturation

    • Principal Investigator
      Aoyama Eriko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Study on adhesion system for composite CAD/CAM blocks using molecular control technology

    • Principal Investigator
      Nagaoka Noriyuki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Prosthodontics/ Dental materials science and
    • Research Institution
      Okayama University

  •  Analysis of the CTGF/CCN2 expression promotion system which classified cartilage regenerative therapy into the field

    • Principal Investigator
      Moritani Norifumi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University

  •  Differential analysis and application at the molecular level of the immunosuppressant action base seen from cartilage tissue

    • Principal Investigator
      NAKATA naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Okayama University

  •  Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational researchPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  ＣＣＮ２個別モジュールの機能解明と変形性関節症治療薬開発に向けた橋渡し研究Host Researcher

    • Host Researcher
      滝川 正春
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Effect of CCN2 on the osteocyte function regulating the osteoclast formation, and its possibility as a novel drug of osteoporosis

    • Principal Investigator
      Nishida Takashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  The presence and its significance of non-canonical action of decoy receptorsPrincipal Investigator

    • Principal Investigator
      TAKIGAWA MASAHARU
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  軟骨細胞分化の運命決定と関節防御ーＣＣＮ３分子機能の新局面Host Researcher

    • Host Researcher
      滝川 正春
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Investigation on the biological diarchy by CCN2 and CCN3 for integrated tissue development

    • Principal Investigator
      Kubota Satoshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Novel function of CCN3: A regulator of endochondral ossification

    • Principal Investigator
      Hattori Takako
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Elucidation of molecular basis of CCN family action as masterminds and its medical applicationPrincipal Investigator

    • Principal Investigator
      TAKIGAWA MASAHARU
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration

    • Principal Investigator
      MIYAKE Yoshiaki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Okayama University

  •  Analysis of molecular mechanism of muscle heterotopic ossification by forming a network with CCN family proteins

    • Principal Investigator
      NISHIDA Takashi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  A new protein transport system in cartilage: Multilayered transcytosisPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  The technological development of bioengineered regenerated tooth, based on the mechanism of development

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Prosthetic dentistry
    • Research Institution
      Okayama University

  •  The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling

    • Principal Investigator
      AOYAMA Eriko
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder

    • Principal Investigator
      HATTORI Takako
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Development and medical application of peptide and RNA aptamers that bind to CCN2

    • Principal Investigator
      KUBOTA Satoshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Clarification of molecular mechanism on the osteoclastogenesis promoted by CCN family 2/connective tissue growth factor

    • Principal Investigator
      NISHIDA Takashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational applicationPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Regulation of CCN family gene expression via micro RNA regulatory network and its Biological signficance

    • Principal Investigator
      KUBOTA Satoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Analysis of the role of cartilage-specific gene in endochondral bone formation using BAC (bacterial artificial chromosome)-transgenic mice

    • Principal Investigator
      HATTORI Takako
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  MMPの新機能:マトリクス合成促進因子の転写因子としての役割Principal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  付着歯肉の分化に関連した特異的遺伝子・蛋白の同定とその機能解析

    • Principal Investigator
      窪木 拓男
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  結合組織成長因子(CCN2/CTGF)を用いた顎顔面領域の三次元軟骨再生

    • Principal Investigator
      藤澤 拓生
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  Establishment of Information Basis for Tooth Regeneration

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems

    • Principal Investigator
      KUBOTA Satoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  RNA干渉を用いたCCN遺伝子ファミリーの包括的機能解析とその応用Principal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Establishment of an autologous cell transplantion method using mesenchymal stem cells for alveolus bone regeneration.

    • Principal Investigator
      FUJISAWA Takuo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用

    • Principal Investigator
      OHYAMA Kazumi, 中西 徹
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  口腔インプラントの骨結合獲得難易度を予測する生物学的診断法の開発

    • Principal Investigator
      窪木 拓男
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineeringPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Cloning, Expression and Identification of Specific Genes related Osseointegration to Titanium.

    • Principal Investigator
      KANYAMA Manabu
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Study of a key factor in chondrogenic differentiation for craniofacial skeletal regeneration

    • Principal Investigator
      YANMAMOTO Teruko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      矯正・小児・社会系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.

    • Principal Investigator
      KUBOTA Satoshi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Molecular mechanism of temporomandibular joint osteoarthritis and gene therapy for degraded, cartilage

    • Principal Investigator
      FUJISAWA Takuo
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Development of the methods for application of the factors that biologically accelerate reparative dentin formation

    • Principal Investigator
      SONOYAMA Wataru
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  MMP-3転写調節部位遺伝子多型からみた顎関節症の予後に関する分子遺伝学的研究

    • Principal Investigator
      水口 一
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  軟骨成長因子エコジェニン/CTGFによる生体デザインを目指す研究Principal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animalsPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Investigation of mechanism of connective tissue growth factor (CTGF) as a molecular target against cancer-induced bone destruction

    • Principal Investigator
      SASAKI Akira
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Molecular cloning of the factors that biologically accelerate reparative dentin formation

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  Ex Vivo Gene Delivery Using an Adenovirus Vector in Treatment for Dental Implant

    • Principal Investigator
      KANYAMA Manabu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Development of analytical method for each domain of CTGF/ecogenin and its clinical application.Principal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Gene therapy for temporomandibular joint osteoarthritis

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Analysis of gene expression in chondrocytes using DNA microarrays (DNA chips)

    • Principal Investigator
      NAKANISHI Tohru
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Investigation of the intracellular function of human ecogenin/CTGF, a chondrocyte-derived growth factor.

    • Principal Investigator
      KUBOTA Satoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  軟骨由来成長因子エコジェニン/CTGFを用いた歯周組織再建への試みPrincipal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  アデノウイルスベクター法を用いた早期osseointegrationの獲得

    • Principal Investigator
      KANYAMA Manabu (完山 学)
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      補綴理工系歯学
    • Research Institution
      Okayama University

  •  Investigation of the regulatory mechanism of gene expression of human ecogenin/CTGF, a chondrocyte-derived growth factor.

    • Principal Investigator
      OHYAMA Kazumi, 服部 高子
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -Principal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Effect of mechanical stress on chondrocytes metabolism

    • Principal Investigator
      KUBOKI Takuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  The cloning and application of growth factors in restorative dentine

    • Principal Investigator
      KANYAMA Manabu, 山下 淳
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      補綴理工系歯学
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseasesPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  アデノウイルスベクターを用いた遺伝子導入法による顎関節症の遺伝子治療の試みPrincipal Investigator

    • Principal Investigator
      滝川 正春
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Basic Research of Gene Therapy for Joint Diseases

    • Principal Investigator
      KUBO Toshikazu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      KYOTO PREFECTURAL UNIVERSITY OF MEDICINE

  •  INVESTIGATION OF MECHANISM OF BONE METTASTASIS AND MOLECULAR CLONING OF BONE METASITASIS RELATED GENE

    • Principal Investigator
      MATSUMURA Tomohiro
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      OKAYAMA UNIVERSITY

  •  Molecular cloning of the receptors for chondrosarcoma-derived chondrocyte growth factor Ecogenin/CTGF

    • Principal Investigator
      NAKANISHI Tohru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossificationPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseasesPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Regulation of IGF-2 gene expression in human chondrosarcoma derived cell lines : HCS-2/8 and -2/A

    • Principal Investigator
      TAKAHASHI Kojiro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell linesPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Expression and promoter-alternation of osteoblastic insulin-like growth factors

    • Principal Investigator
      TAKAHASHI Kojiro
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University

  •  Studies on the mechanism of endochondral ossification using a clonal chondrocyte like cell line newly established from a human chondrosarcoma - approach using the methods of cellular and molecular biologyPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Osaka University

  •  Purification of Receptors to Parathyroid Hormone from Cultured Chondrocytes and the Mechanism of its Signal Transduction

    • Principal Investigator
      ASADA Akira
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Osaka University

  •  Studies on mechanisms of proliferation, differentiation and calcification of chondrocytes using established clonal cell lines.Principal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Osaka University

  •  軟骨細胞の増殖・分化と骨形成におけるビタミンDの作用機作

    • Principal Investigator
      SHIRAI Eiji
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Osaka University

  •  Purification of cartilage-derived anti-tumor factor (CATF) and establishment of cell lines which produce CATFPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Osaka University

  •  Bioassays for parathyrois hormone using clutures chondrocytesPrincipal Investigator

    • Principal Investigator
      TAKIGAWA Masaharu
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      General medical chemistry
    • Research Institution
      Osaka University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2001 Other

All Journal Article Presentation Book Patent

  • [Book] CCN Proteins-Methods and Protocols, 2nd Edition2022
    • Author(s)
      Takigawa M
    • Publisher
      Springer-Nature
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Book] CCN Proteins-Methods and Protocols, 2nd Edition2022
    • Author(s)
      Takigawa M
    • Publisher
      Springer-Nature
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Book] CCN. Encyclopedia of Signaling Molecules (Choi S. ed.), 2nd edition2018
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Total Pages
      6060
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Book] Analysis of transcytosis of CCN2 by chondrocytes.　in Methods in Molecular Biology: CCN Proteins: Methods and Protocols (ed. M. Takigawa)2017
    • Author(s)
      1. Kawata K, Kubota S, Takigawa M
    • Total Pages
      576
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-16K11475

  • [Book] CCN2. Encyclopedia of Signaling Molecules (Choi S. ed.), 2nd edition2017
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Book] CCN Proteins: Methods and Protocols2016
    • Author(s)
      Takigawa M.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Book] Evaluation of molecular interaction between CCN family 2 protein and binding partners by surface plasmon resonance (SPR) in Method in Molecular Biology: CCN proteins2016
    • Author(s)
      Aoyama E., Takigawa M
    • Total Pages
      576
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Book] In vitro transfection with and expression of CCN family of genes. In Methods in Molecular Biology - CCN Proteins: Methods and Protocols (ed. M. Takigawa)2016
    • Author(s)
      Janune D. and Takigawa M.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-13F03412

  • [Book] CCN Proteins: Methods and Protocols (one of the "Methods in Molecular Biology" book series)2016
    • Author(s)
      Takigawa M.(ed)
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Book] Production of recombinant CCN family2 protein in Escherichia. coli. in Method in Molecular Biology: CCN proteins2016
    • Author(s)
      Aoyama E., Hattori T., Kubota S., Takigawa M
    • Total Pages
      576
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Book] CCN Proteins: Methods and Protocols2016
    • Author(s)
      Takigawa M.(ed)
    • Total Pages
      576
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Book] In : Encyclopedia of Signaling Molecules(Sangdun Choi ed)2012
    • Author(s)
      Kubota, S. and M. Takigawa
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] Nucleophosmin/B23 : A multifunctional regulator that determines the fate of ccn2 mRNA. In : CCN Proteins in Health and Disease(A. Perbal, M. Takigawa & B. Perbal eds)2010
    • Author(s)
      Kubota, S., Y. Mukudai, H. Kawaki, S. Kondo, T. Eguchi, K. Sumiyoshi, T. Ohgawara, T. Shimo and M. Takigawa
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] CCN Proteins in Health and Disease.(A.Perbal, M.Takigawa, B.Perbal(eds))(Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3.)2010
    • Author(s)
      Takigawa M., et al.
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. In : CCN Proteins in Health and Disease(A. Perbal, M. Takigawa & B. Perbal eds)2010
    • Author(s)
      Takigawa, M., H. Kawaki, S. Kubota, K. M. Lyons and B. Perbal
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. In : CCN Proteins in Health and Disease2010
    • Author(s)
      Takigawa, M., et al.
    • Publisher
      Springer, Dordrecht, Netherlands(印刷中)
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] Novel transcriptional regulation of CCN2/CTGF by nuclear translocation of MMP3. In : CCN Proteins in Health and Disease(A. Perbal, M. Takigawa & B. Perbal eds)2010
    • Author(s)
      Eguchi, T., S. Kubota, K. Kawata, Y. Mukudai, J. Uehara, T. Ohgawara, S. Ibaragi, A. Sasaki, T. Kuboki and M. Takigawa
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. in CCN Proteins in Health and Disease. A. Perbal, M. Takigawa & B. Perbal(eds)2010
    • Author(s)
      Takigawa M., et al.
    • Publisher
      Springer(Dordrecht, Nertherlands)(in press.)
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3. in CCN Proteins in Health and Disease. A.Perbal, M.Takigawa & B.Perbal (ads)2010
    • Author(s)
      Takigawa M., et al.
    • Publisher
      Springer (Dordrecht, Nertherlands)
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Book] CCN Proteins in Health and Disease2010
    • Author(s)
      Perbal A, Takigawa M, Perbal B.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Book] Cooperative regulation of cell proliferation and differentiation by CCN2 and CCN3.(CCN Proteins in Health and Disease. A. Perbal)(M.Takigawa, B.Perbal (eds))2010
    • Author(s)
      Takigawa M, 他
    • Publisher
      Springer, Dordrecht, Nertherlands
    • Data Source
      KAKENHI-PROJECT-20592173

  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth. In Internal Review of Cytology, Vol. 257 (K.W. Jeon ed.)2007
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Publisher
      Academic Press (Amsterdam)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Role of CCN2/CTGF/Hcs24 in Bone Growth.In ; International Review of Cytology (K.W. Jeon. ed)(Vol.147)2007
    • Author(s)
      Kubota, S. and M.Takigawa
    • Publisher
      Elsevier Inc.,San Diego
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Book] CCN22007
    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In UCSD-Nature Molecular Pages (online database)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth. In Internal Review of Cytology:A Survey of Cell Biology, Vol. 257(K.W. Jeon ed.)2007
    • Author(s)
      Kubota S. and Takigawa M.
    • Publisher
      Academic Press (Amsterdam)
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Book] 結合組織成長因子CTGF/CCN2(Connective tissue growth factor(CTGF)/CCN2)The Lung perspectives(15(3))2007
    • Author(s)
      服部高王、久保田聡、滝川正春
    • Publisher
      メディカルレビュー社、大阪
    • Data Source
      KAKENHI-PROJECT-19592145

  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth2007
    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Internal Review of Cytology (review journal), Vol. 257 (K.W. Jeon ed.) Academic Press (Amsterdam)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] International Review of Cytology2007
    • Author(s)
      Kubota S. and Takigawa M.
    • Publisher
      Elsevier Inc.
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Book] Role of CCN2/CTGF/Hcs24 in bone growth. In Internal Review of Cytology: A Survey of Cell Biology, Vol. 257 (K. W. Jeon ed.)2007
    • Author(s)
      Kubota S. and Takigawa M.
    • Publisher
      Academic press (Amsterdam)
    • Data Source
      KAKENHI-PROJECT-19659487

  • [Book] UCSD-Nature Molecular Pages: CCN2.(online database)2007
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Publisher
      Nature Publishing Group
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] International Review of Cytology : A Survey of Cell Biology2007
    • Author(s)
      Kubota S, Takigawa M
    • Total Pages
      41
    • Publisher
      ACDEMIC PRESS
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] 軟骨修復-CCN2/CTGF 細胞増殖因子と再生医療2006
    • Author(s)
      久保田聡、滝川正春
    • Publisher
      メディカルレビュー社 大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] The CCN proteins-The CCN family of proteins : an overview2005
    • Author(s)
      Perbal, B., Takigawa, M
    • Publisher
      In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.), Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators2005
    • Author(s)
      Takigawa, M. et al.
    • Publisher
      Perbal B. & Takigawa M.(eds.), Imperial College Press, London(in press)
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.)2005
    • Author(s)
      Takigawa, M., et. al.
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration2005
    • Author(s)
      Takigawa, M., et. al.
    • Publisher
      In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators (Perbal B. & Takigawa M. eds.), Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Trend in Stem Cell Research(CTGF/Hcs24・CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells.)2005
    • Author(s)
      Takigawa M(Erik V.Greer.ed.)
    • Total Pages
      245
    • Publisher
      Nova Science(New York)
    • Data Source
      KAKENHI-PROJECT-16659511

  • [Book] Roles of CCN2/CTGF in the control of growth and regeneration. In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators(Perbal B. & Takigawa M. (eds.))2005
    • Author(s)
      Takigawa, M. et al.
    • Publisher
      Imperial College Press, London (in press)
    • Data Source
      KAKENHI-PROJECT-16659511

  • [Book] CCN Proteins : A New Family of Cell Growth and Differentiation Regulators2005
    • Author(s)
      Perbal, B., Takigawa, M.(eds.)
    • Total Pages
      311
    • Publisher
      Imperial College Press(London)
    • Data Source
      KAKENHI-PROJECT-16659511

  • [Book] The CCN proteins - An Overview. In CCN Proteins : A New Family of Cell Growth and Differentiation Regulators(Perbal B. & Takigawa M. (eds.))2005
    • Author(s)
      Perbal, B., Takigawa, M.
    • Publisher
      Imperial College Press, London (in press)
    • Data Source
      KAKENHI-PROJECT-16659511

  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells2005
    • Author(s)
      Takigawa, M
    • Publisher
      In Progress in Stem Cell Research (Columbus F, ed.) Nova Science (Hauppauge, NY)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] CCN Proteins : A New Family of Cell Growth and Differentiation Regulators.2005
    • Author(s)
      Perbal, B., Takigawa, M.(Editors)
    • Total Pages
      311
    • Publisher
      Imperial College Press (London)
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells. In Trends in Stem Cell Research2005
    • Author(s)
      Takigawa, M.
    • Publisher
      Columbus F.(ed), Nova Science, Hauppauge, NY(in press)
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] The CCN proteins-A New Family of Cell Growth and Differentiation Regulators (edited book)2005
    • Author(s)
      Perbal, B., Takigawa, M
    • Publisher
      Imperial College Press (London)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] The CCN proteins - An Overview. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators2005
    • Author(s)
      Perbal, B., Takigawa, M.
    • Publisher
      Perhal B. & Takigawa M.(eds.), Imperial College Press, London(in press)
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] CTGF/Hcs24/CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells. In Progress in Stem Cell Research (Columbus F, ed)2005
    • Author(s)
      Takigawa, M.
    • Publisher
      Nova Science, Hauppauge, Ny
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Trend in Stem Cell Research (CTGF/Hcs24・CCN2 as a regeneration factor ("regenerin") acting on various types of mesenchymal cells.)2005
    • Author(s)
      Takigawa M (Erik V.Greer.ed.)
    • Total Pages
      245
    • Publisher
      Nova Science (New York)
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] CCN Proteins: A New Family of Cell Growth and Differentiation Regulators.2005
    • Author(s)
      Perbal, B. and Takigawa, M. (Editors, 編集)
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] The CCN proteins-The CCN family of proteins: an overview. In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators(Perbal B.& Takigawa M.eds.)2005
    • Author(s)
      Perbal, B. and Takigawa, M.
    • Publisher
      Imperial College Press, London
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Driving the driver: Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation.2003
    • Author(s)
      Kubota S and Takigawa M
    • Publisher
      Recent Res. Develop. Biophys. Biochem. 3(part 2)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] 1.細胞増殖因子を用いた組織再生療法 5)細胞増殖因子を用いた軟骨組織再生療法.遺伝子医学別冊「ドラッグデリバリーシステムDDS技術の新たな展開とその活用法」(田畑 泰彦編)2003
    • Author(s)
      西田 崇, 滝川正春
    • Publisher
      メディカルドウ社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] Driving the driver : Molecular regulation of ctgf/HCS24/ccn2 that regulates chondrocyte growth and differentiation2003
    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Recent Res. Develop. Biophys. Biochem
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] 1. Tissue regeneration using growth factors. 5) Cartilage regeneration using growth factor (in Japanese)2003
    • Author(s)
      Nishida, T., Takigawa, M
    • Publisher
      In Development and New Application of Drug Delivery System DDS Technology (Tabata Y. ed.) Medical Do (Osaka)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Book] ドラッグデリバリーシステム、DDS技術の新たな展開とその活用法(田畑泰彦編、メディカルドウ社)2003
    • Author(s)
      西田 崇, 滝川正春
    • Publisher
      1.細胞増殖因子を用いた組織再生療法 5)細胞増殖因子を用いた軟骨組織再生療法
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Book] 新・分子骨代謝学と骨粗鬆症(松本俊夫編:メディカルレビュー社)2001
    • Author(s)
      中西 徹、滝川正春
    • Publisher
      軟骨細胞の分化制御と軟骨形成
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Book] Cartilage repair : 10. CTGF(in Japanese)
    • Author(s)
      Kubota, S., Takigawa, M
    • Publisher
      In Growth Factors & Regenerative Medicine (Matsumoto T. & Tabata Y., eds.) Medical Review, (Osaka)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] Evaluation of the Molecular Interaction between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance2022
    • Author(s)
      Eriko Aoyama and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Imaging of Molecular Interaction between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes2022
    • Author(s)
      Mitsuhiro Hoshijima, Eriko Aoyama, Hiroshi Kamioka, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] CCN Proteins: Cellular Communication Network Factors：Expanding their repertoire toward a new concept2022
    • Author(s)
      Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Angiogenesis Assays for The Analysis of CCN Proteins2022
    • Author(s)
      Tsuyoshi Shimo, Mari Shimatani, Akihiko Tanimura and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins2022
    • Author(s)
      Takashi Nishida, Satoshi Kubota and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Protocols for Screening Peptides Binding to CCN Family Proteins and their Extended Utility2022
    • Author(s)
      Satoshi Kubota, Harumi Kawaki and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Imaging of Molecular Interaction between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes2022
    • Author(s)
      Mitsuhiro Hoshijima, Eriko Aoyama, Hiroshi Kamioka, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction By LIPUS Of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues2022
    • Author(s)
      Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Toshifumi Ozaki, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Evaluation of the Molecular Interaction between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance2022
    • Author(s)
      Eriko Aoyama and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Mouse models of tumor bone metastasis and invasion for the studying CCN proteins2022
    • Author(s)
      Tsuyoshi Shimo, Tatsuo Okui, Naohiro Horie, Kenji Yokozeki, Masaharu Takigawa and Akira Sasaki
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Cellular Fluorescence Imaging for The Evaluation of Bioactivity of CCN Family Proteins2022
    • Author(s)
      Harumi Kawaki, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] CCN Proteins: Cellular Communication Network Factors：Expanding their repertoire toward a new concept2022
    • Author(s)
      Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Cellular Fluorescence Imaging for The Evaluation of Bioactivity of CCN Family Proteins2022
    • Author(s)
      Harumi Kawaki, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Analyses of the Post-transcriptional Regulation of CCN Genes-Approach to Multiple Steps of ccn2 Gene Expression-2022
    • Author(s)
      Seiji Kondo, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction By LIPUS Of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues.2022
    • Author(s)
      Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Toshifumi Ozaki, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] Analyses of the Post-transcriptional Regulation of CCN Genes - Approach to Multiple Steps of ccn2 Gene Expression -2022
    • Author(s)
      Seiji Kondo, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Protocols for Screening Peptides Binding to CCN Family Proteins and their Extended Utility2022
    • Author(s)
      Satoshi Kubota, Harumi Kawaki and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Journal Article] Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins2022
    • Author(s)
      Takashi Nishida, Satoshi Kubota and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Journal Article] RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions2021
    • Author(s)
      Mizukawa Tomomi、Nishida Takashi、Akashi Sho、Kawata Kazumi、Kikuchi Sumire、Kawaki Harumi、Takigawa Masaharu、Kamioka Hiroshi、Kubota Satoshi
    • Journal Title

      J Cell Physiol.

      Volume: in press Pages: 6884-6896

    • DOI

      10.1002/jcp.30348

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18756, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-21H03105, KAKENHI-PROJECT-19K10109, KAKENHI-PROJECT-20K09889, KAKENHI-PROJECT-21K09904, KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-21K19603

  • [Journal Article] Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1.2021
    • Author(s)
      Elseoudi Abdellatif、Nishida Takashi、Mizukawa Tomomi、Hattori Takako、Kawata Kazumi、Taha Eman A.、Takigawa Masaharu、Kubota Satoshi
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 15 Pages: 81-91

    • DOI

      10.1007/s12079-020-00600-4

    • NAID

      120007182886

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-21H03105, KAKENHI-PROJECT-19K10109, KAKENHI-PROJECT-20K09889, KAKENHI-PROJECT-21K09815, KAKENHI-PROJECT-21K19603

  • [Journal Article] Gel- Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer.2021
    • Author(s)
      Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K.
    • Journal Title

      Cells

      Volume: 12 Pages: 344-344

    • DOI

      10.3390/cells10020344

    • NAID

      120006860095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10053, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-20K09904

  • [Journal Article] Effect of angiotensin II on chondrocyte degeneration and protection via differential usage of angiotensin II receptors.2021
    • Author(s)
      Nishida Takashi、Akashi Sho、Takigawa Masaharu、Kubota Satoshi
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 22 Pages: 9204-9204

    • DOI

      10.3390/ijms22179204

    • NAID

      120007147372

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-21H03105, KAKENHI-PROJECT-20K09889, KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-21K19603

  • [Journal Article] Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT32020
    • Author(s)
      Sogawa C, Eguchi T, Tran MT, Ishige M, Trin K, Okusha Y, Taha EA, Lu Y, Kawai H, Sogawa N, Takigawa M, Calderwood SK, Okamoto K, Kozaki KI.
    • Journal Title

      Cancers (Basel)

      Volume: 12(2). Pages: 523-523

    • DOI

      10.3390/cancers12020523

    • NAID

      120006840778

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-17K11689, KAKENHI-PROJECT-18K17224

  • [Journal Article] Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS‐2/8 Chondrosarcoma Cells2020
    • Author(s)
      W. P. Shield, 3rd, A. Cellini, H. Tian, K. Wilson, Y. Dan, J. M. Abzug, S. Garcia, N. Moritani, I. Alferiev, M. Chorny, M. Takigawa, V. Y. Ng, M. Iwamoto.M. Enomoto-Iwamoto.
    • Journal Title

      Journal of Orthopaedic Research

      Volume: - Pages: 1045-1051

    • DOI

      10.1002/jor.24555

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09743, KAKENHI-PROJECT-19H03817

  • [Journal Article] Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer2020
    • Author(s)
      Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K.
    • Journal Title

      Cancers (Basel)

      Volume: 12(4). Pages: 881-881

    • DOI

      10.3390/cancers12040881

    • NAID

      120006860095

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19H04051

  • [Journal Article] Regulation of cellular communication factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis.2020
    • Author(s)
      Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
    • Journal Title

      J. Oral Biosci.

      Volume: 62 Pages: 280-288

    • DOI

      10.1016/j.job.2020.07.001

    • NAID

      120007147394

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10109, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-20K09889, KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K22716

  • [Journal Article] Roles of interaction between CCN2 and Rab14 in aggrecan production by chondrocytes.2020
    • Author(s)
      Hoshijima M, Hattori T, Aoyama E, Nishida T, Kubota S, Kamioka H, Takigawa M.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 2769-2769

    • DOI

      10.3390/ijms21082769

    • NAID

      120006862789

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K19293, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-19K10053, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-20K09889, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K22716

  • [Journal Article] Suppression of adipocyte differentiation by low-intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2.2020
    • Author(s)
      Nishida T, Nagao Y, Hashitani S, Yamanaka N, Takigawa M, Kubota S
    • Journal Title

      J. Cell. Biochem.

      Volume: - Pages: 29680-29680

    • DOI

      10.1002/jcb.29680

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-20K09889

  • [Journal Article] Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesiclesdriven malignancy events and macrophage M2 polarization in oral cancer.2020
    • Author(s)
      Ono K, Sogawa C, Kawai H, Tran MT, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki K, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T
    • Journal Title

      Journal of Extracellular Vesicles

      Volume: in press Pages: 1769373-1769373

    • DOI

      10.1080/20013078.2020.1769373

    • NAID

      120006956812

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-20K09904, KAKENHI-PROJECT-18K17224, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K24072

  • [Journal Article] CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage2020
    • Author(s)
      Kuwahara Miho、Kadoya Koichi、Kondo Sei、Fu Shanqi、Miyake Yoshiko、Ogo Ayako、Ono Mitsuaki、Furumatsu Takayuki、Nakata Eiji、Sasaki Takako、Minagi Shogo、Takigawa Masaharu、Kubota Satoshi、Hattori Takako
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 7556-7556

    • DOI

      10.3390/ijms21207556

    • NAID

      120006900771

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-20K20611, KAKENHI-PROJECT-19K17399, KAKENHI-PROJECT-20K18601, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-19K22716

  • [Journal Article] CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction2020
    • Author(s)
      Ohkawara Bisei、Kobayakawa Akinori、Kanbara Shunsuke、Hattori Takako、Kubota Satoshi、Ito Mikako、Masuda Akio、Takigawa Masaharu、Lyons Karen M、Ishiguro Naoki、Ohno Kinji
    • Journal Title

      EMBO reports

      Volume: 21

    • DOI

      10.15252/embr.201948462

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06058, KAKENHI-PROJECT-18K06483, KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19K22802, KAKENHI-PROJECT-19H03779, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-20H03561, KAKENHI-PROJECT-19K22716

  • [Journal Article] The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin2019
    • Author(s)
      Khattab HM, Kubota S, Takigawa M, Kuboki T, Sebald W.
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 37 Pages: 119-205

    • DOI

      10.1007/s00774-018-0925-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11624, KAKENHI-PROJECT-17K19756

  • [Journal Article] Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation.2019
    • Author(s)
      Nishida T, Kubota S, Yokoi H, Mukoyama M, Takigawa M
    • Journal Title

      Sci. Rep.

      Volume: 9 Pages: 10913-10913

    • DOI

      10.1038/s41598-019-47285-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10150, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19H03817, KAKENHI-PROJECT-17K09697, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-17K11641

  • [Journal Article] A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability2019
    • Author(s)
      Sogawa C, Eguchi T, Okusha Y, Ono K, Ohyama K, Iizuka M, Kawasaki R, Hamada Y, Takigawa M, Sogawa N, Okamoto K, and Kozaki K.
    • Journal Title

      Tissue Eng Part A

      Volume: in press Pages: 1413-1425

    • DOI

      10.1089/ten.tea.2018.0348

    • NAID

      120006788780

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-17K11689, KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-19H03817

  • [Journal Article] Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells.2019
    • Author(s)
      Shoji Masaki, Ueda Masako, Nishioka Megumi, Minato Hiroki, Seki Masahide, Harada Kenichiubo Miwa, Fukuyama Yoshiyasu, Suzuki Yutaka, Aoyama Eriko, Takigawa Masaharu, Kuzuhara Takashi
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 519 Pages: 309-315

    • DOI

      10.1016/j.bbrc.2019.09.003

    • NAID

      120006842045

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K01921, KAKENHI-PROJECT-18K06645, KAKENHI-PROJECT-19K05488, KAKENHI-PROJECT-19K10053, KAKENHI-PROJECT-19H03817

  • [Journal Article] Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus2019
    • Author(s)
      Kamatsuki, Y, Aoyama, E., Furimatsu, T., Miyazawa, S., Maehara, A., Yamanaka, N., Nishida, T., Kubota, S., Ozaki, T., Takigawa, M
    • Journal Title

      J Cell Commun Signal

      Volume: 13 Pages: 193-207

    • DOI

      10.1007/s12079-018-0496-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-19K10053, KAKENHI-PROJECT-19K22716, KAKENHI-PROJECT-19H03817

  • [Journal Article] CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi.2019
    • Author(s)
      Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
    • Journal Title

      J Cell Commun Signal.

      Volume: 13(1) Issue: 1 Pages: 113-118

    • DOI

      10.1007/s12079-018-0487-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06263, KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-18K19344, KAKENHI-PROJECT-16H04795, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K10053

  • [Journal Article] Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment2018
    • Author(s)
      Eguchi Takanori, Sogawa C, Okusha Y, Uchibe K, Iinuma R, Ono K, Nakano K, Murakami J, Itoh M, Arai K, Fujiwara T, Namba Y, Murata Y, Ohyama K, Shimomura M, Okamura H, Takigawa M, Nakatsura T, Kozaki KI, Okamoto K, Calderwood SK.
    • Journal Title

      PLoS One

      Volume: 13 Pages: 1-34

    • DOI

      10.1371/journal.pone.0191109

    • NAID

      120006489931

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11642, KAKENHI-PROJECT-17K11643, KAKENHI-PROJECT-17K11669, KAKENHI-PROJECT-17K17895, KAKENHI-PROJECT-15H05014

  • [Journal Article] An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin2018
    • Author(s)
      Takigawa M
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: 12(1) Pages: 253-264

    • DOI

      10.1007/s12079-017-0414-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-17K19757

  • [Journal Article] Physiological role of urothelial cancer-associated 1 long noncoding RNA in human skeletogenic cell differentiation.2018
    • Author(s)
      Ishikawa T, Nishida T, Ono M, Takarada T, Nguyen HT, Kurihara S, Furumatsu T, Murase Y, Takigawa M, Oohashi T, Kamioka H, Kubota S
    • Journal Title

      J. Cell. Physiol.

      Volume: 233(6) Pages: 4825-4840

    • DOI

      10.1002/jcp.26285

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16H05524, KAKENHI-PROJECT-17H06885, KAKENHI-PROJECT-16K15802, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17H04399, KAKENHI-PROJECT-17K19756

  • [Journal Article] Metabolic regulation of the CCN family of genes by glycolysis in chondrocytes2018
    • Author(s)
      Akashi S, Nishida T, El-Seoudi A, Takigawa M, Iida S, Kubota S.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 12 Pages: 245-252

    • DOI

      10.1007/s12079-017-0420-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-17K11641

  • [Journal Article] Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling2018
    • Author(s)
      Matsumoto Kenichi、Shimo Tsuyoshi、Kurio Naito、Okui Tatsuo、Ibaragi Soichiro、Kunisada Yuki、Obata Kyoichi、Masui Masanori、Pai Pang、Horikiri Yuu、Yamanaka Nobuyuki、Takigawa Masaharu、Sasaki Akira
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 印刷中 Pages: 4352-4360

    • DOI

      10.1002/jcb.26418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16H06992

  • [Journal Article] Evaluation of Molecular Interaction between CCN2 Protein and Its Binding Partners by Surface Plasmon Resonance (SPR).2017
    • Author(s)
      Aoyama E, Takigawa M.
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 169-176

    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Journal Article] Generation and analyzing cartilage specific CCN2 overexpressing transgenic mice,2017
    • Author(s)
      Hattori T, Itoh S, and Takigawa M
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 1489 Pages: 391-403

    • DOI

      10.1007/978-1-4939-6430-7_32

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K20587, KAKENHI-PROJECT-16K11476

  • [Journal Article] Protocols for screening binding partners to CCN proteins: Yeast two hybrid system2017
    • Author(s)
      Hoshijima M, Hattori T, Takigawa M
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 1489 Pages: 145-154

    • DOI

      10.1007/978-1-4939-6430-7_15

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16K11476, KAKENHI-PROJECT-16K11786

  • [Journal Article] Production of Recombinant CCN2 Protein in Escherichia coli.2017
    • Author(s)
      Aoyama E, Hattori T, Kubota S, Takigawa M.
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 77-84

    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Journal Article] Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes2017
    • Author(s)
      Hori A, Nishida T, Takashiba S, Kubota S, Takigawa M.
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI

      10.1371/journal.pone.0188014

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-17K19757, KAKENHI-PROJECT-15H05014

  • [Journal Article] Production of recombinant CCN family 2 protein in Escherichia coli.2017
    • Author(s)
      Aoyama E, Hattori T, Kubota S and Takigawa M
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 1489 Pages: 77-84

    • DOI

      10.1007/978-1-4939-6430-7_8

    • Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16K11476

  • [Journal Article] Intracellular MMP3 promotes HSP gene expression in collaboration with chromobox proteins.2017
    • Author(s)
      Eguchi T, Calderwood SK, Takigawa M, Kubota S, Kozaki K
    • Journal Title

      J Cell Biochem.

      Volume: 118(1) Pages: 43-51

    • DOI

      10.1002/jcb.25607

    • NAID

      120006488562

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] ELISA of CCN family proteins in body fluids including serum and plasma.2017
    • Author(s)
      Kubota S, Kawaki H and Takigawa M
    • Journal Title

      Methods of Molecular Biology

      Volume: 1489 Pages: 127-138

    • DOI

      10.1007/978-1-4939-6430-7_13

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-26462984

  • [Journal Article] Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis2017
    • Author(s)
      El-Seoudi A, Abd El Kader T, Nishida T, Eguchi T, Aoyama E, Takigawa M, Kubota S
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: in press Pages: 255-263

    • DOI

      10.1007/s12079-017-0384-8

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-14F04420, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-15K11038

  • [Journal Article] A tumor suppressor gene product, platelet-derived growth factor receptor-like protein controls controls chondrocyte proliferation and differentiation.2017
    • Author(s)
      Kawata K, Kubota S, Eguchi T, Aoyama E, Moritani NH, Oka M, Kawaki H, Takigawa M.
    • Journal Title

      J Cell Biochem.

      Volume: 118(11) Pages: 4033-4044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11475

  • [Journal Article] 骨リモデリングにおける骨細胞の役割2017
    • Author(s)
      西田　崇、久保田聡、滝川正春
    • Journal Title

      Clin. Calcium

      Volume: 27(12) Pages: 1697-1703

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation.2017
    • Author(s)
      Nishida T, Kubota S, Aoyama E, Yamanaka N, Lyons KM, Takigawa M
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 25 Pages: 759-769

    • DOI

      10.1016/j.joca.2016.10.003

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19756

  • [Journal Article] ovel role of CCN3 that maintains the differentiated phenotype of articular cartilage.2017
    • Author(s)
      Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, Takigawa M
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: in press Pages: 582-597

    • DOI

      10.1007/s00774-016-0793-4

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-14F04420, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-17K11641, KAKENHI-PROJECT-17K19756, KAKENHI-PROJECT-15K11038

  • [Journal Article] A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor Receptor-Like Protein Controls Chondrocyte Proliferation and Differentiation2017
    • Author(s)
      Kawata K, Kubota S, Eguchi T, Aoyama, E, Moritani N, Oka M, Kawaki H, and Takigawa M.
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 118 Pages: 4033-4044

    • DOI

      10.1002/jcb.26059

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11817, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-15K11247

  • [Journal Article] Protein Imaging of CCN2 and CCN3 in a live cell, in Methods in Molecular Biology2017
    • Author(s)
      Hattori T, Hoshijima M, and Takigawa M
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 1489 Pages: 211-215

    • DOI

      10.1007/978-1-4939-6430-7_20

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-16K11476, KAKENHI-PROJECT-16K11786

  • [Journal Article] Protocols for screening peptide motifs binding to CCN family proteins.2017
    • Author(s)
      Kubota S, Kawaki H and Takigawa M
    • Journal Title

      Methods of Molecular Biology

      Volume: 1489 Pages: 155-167

    • DOI

      10.1007/978-1-4939-6430-7_16

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-26462984

  • [Journal Article] Analysis of expression of CCN family genes in skeletal tissue-derived cells2017
    • Author(s)
      Kawaki H, Kubota K, and Takigawa M
    • Journal Title

      Methods of Molecular Biology

      Volume: 1489 Pages: 33-41

    • DOI

      10.1007/978-1-4939-6430-7_4

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-26462984

  • [Journal Article] UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage?specific manner2017
    • Author(s)
      Tokiro Ishikawa, Takuya Toyama, Yuki Nakamura, Kentaro Tamada, Hitomi Shimizu, Satoshi Ninagawa, Tetsuya Okada, Yasuhiro Kamei, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Eriko Aoyama, Masaharu Takigawa, Akihiro Harada and Kazutoshi Mori
    • Journal Title

      The Journal of Cell Biology.

      Volume: 印刷中 Pages: 99-100

    • DOI

      10.1083/jcb.201609100

    • NAID

      120006343784

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K18529, KAKENHI-PROJECT-17K15116, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-17H01432, KAKENHI-PROJECT-15H04668, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-16K18538, KAKENHI-PLANNED-17H06422

  • [Journal Article] 骨リモデリングにおける骨細胞の役割2017
    • Author(s)
      西田　崇、久保田聡、滝川正春
    • Journal Title

      Clin. Calcium

      Volume: 27 Pages: 1697-1703

    • Open Access
    • Data Source
      KAKENHI-PROJECT-17K11641

  • [Journal Article] Evaluation of Molecular Interaction between CCN2 Protein and Its Binding Partners by Surface Plasmon Resonance (SPR).2016
    • Author(s)
      Aoyama E and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 169-176

    • DOI

      10.1007/978-1-4939-6430-7_17

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] The CCN Proteins：An overview2016
    • Author(s)
      Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Analysis of signaling pathways activated by CCN proteins.2016
    • Author(s)
      Kawaki, H., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Analysis of transcytosis of CCN2 by chondrocytes2016
    • Author(s)
      Kawata K., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In vivo evaluation of cartilage regenerative effects of CCN2 protein.2016
    • Author(s)
      Nishida, T., Kubota, S., Takigawa, M.
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 未定

    • Data Source
      KAKENHI-PROJECT-26462810

  • [Journal Article] Analysis of expression of CCN family genes in skeletal tissue-derived cells2016
    • Author(s)
      Kawaki H., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In Vitro Transfection with and Expression of CCN Family of Genes.2016
    • Author(s)
      Janune D and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 107-113

    • DOI

      10.1007/978-1-4939-6430-7_11

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In Vivo Evaluation of Cartilage Regenerative Effects of CCN2 Protein2016
    • Author(s)
      Nishida T, Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 273-282

    • DOI

      10.1007/978-1-4939-6430-7_25

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Sorcin expression in the epiphyseal growth plates of mice2016
    • Author(s)
      Kawai M., Liu N., Hattori T., Kataoka Y-H., Takigawa M., Kubota S., Yamamoto T. and Ohura K.
    • Journal Title

      J. Hard Tissue Biol.

      Volume: 25 Pages: 57-62

    • NAID

      130005119559

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Cell biological assays for measuring chondrogenic activities of CCN2 protein.2016
    • Author(s)
      Nishida, T., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function.2016
    • Author(s)
      Yoshioka Y, Ono M, Maeda A, Kilts TM, Hara ES, Khattab H, Ueda J, Aoyama E, Oohashi T, Takigawa M, Young MF, Kuboki T.
    • Journal Title

      Bone

      Volume: 83 Pages: 162-70

    • DOI

      10.1016/j.bone.2015.11.007

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K11038

  • [Journal Article] ELISA of CCN Family proteins in body fluids including serum and plasma.2016
    • Author(s)
      Kubota, S., H. Kawaki and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Analysis of post-transcriptional regulation of CCN genes.2016
    • Author(s)
      Kondo, S., S. Kubota, and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Western blotting analysis of CCN proteins in Calcified Tissues.2016
    • Author(s)
      Kawaki H, Kubota K, and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 43-51

    • DOI

      10.1007/978-1-4939-6430-7_5

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Gene Expression Analysis of CCN Proteins: Whole-Mount In Situ Hybridization of Ccn2 in Developing Calcified Tissues.2016
    • Author(s)
      Yamaai T and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 11-19

    • DOI

      10.1007/978-1-4939-6430-7_2

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Role of CCN2 in amino acid metabolism of chondrocytes.2016
    • Author(s)
      Murase, Y,, Hattori, T., Aoyama, E., Nishida, T., Maeda-Uematsu, A., Kawaki, H., Lyons, K. M., Sasaki, A., Takigawa, M., Kubota, S
    • Journal Title

      J Cell Biochem.

      Volume: 117 Pages: 927-37

    • DOI

      10.1002/jcb.25377

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-26462984, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-16K11476

  • [Journal Article] Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure2016
    • Author(s)
      Takeuchi, H., S. Kubota, T. Tachibana, E. Murakashi, M. Takigawa, M. Okabe and Y. Numabe.
    • Journal Title

      Odontology

      Volume: 104 Pages: 35-43

    • DOI

      10.1007/s10266-014-0177-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-15H05014

  • [Journal Article] Production of Recombinant CCN2 Protein by Mammalian Cells2016
    • Author(s)
      Nishida T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Production of recombinant CCN2 protein in Escherichia. Coli2016
    • Author(s)
      Aoyama E., Hattori T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of Pathological Activities of CCN Proteins in Bone Metastasis.2016
    • Author(s)
      Shimo T, Yoshioka N, Takigawa M, Sasaki A
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 505-512

    • DOI

      10.1007/978-1-4939-6430-7_42

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Western blotting analyses of CCN proteins.2016
    • Author(s)
      Kawaki, H., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Gene expression analysis of CCN proteins: Whole mount in situ hybridization of CCN2 in developing calcified tissues2016
    • Author(s)
      Yamaai T. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Generation and analyzing cartilage specific CCN2 overexpressing transgenic mice2016
    • Author(s)
      Takako Hattori, Shinsuke Itoh and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] Protein Imaging of CCN2 and CCN3 in a live cell2016
    • Author(s)
      Takako Hattori, Mitsuhiko Hoshijima, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues2016
    • Author(s)
      Hara C., Kubota S., Nishida T., Hiasa M., Hattori T., Aoyama E., Moriyama Y., Kamioka H., Takigawa M.
    • Journal Title

      Mod. Rheumatol.

      Volume: 26 Pages: 1-32

    • NAID

      120006358661

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of transcytosis of CCN2 by chondrocytes.2016
    • Author(s)
      Kawata, K., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] ELISA of CCN proteins in body fluids including serum and plasma2016
    • Author(s)
      Kubota S., Kawaki H. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues2016
    • Author(s)
      Hara, C., Kubota, S., Nishida, T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H., Takigawa, M
    • Journal Title

      Mod. Rheumatol

      Volume: In press

    • NAID

      120006358661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Journal Article] Production of recombinant CCN family 2 protein in Escherichia coli.2016
    • Author(s)
      Eriko Aoyama, Takako Hattori, Satoshi Kubota, Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] The CCN Proteins: An Overview.2016
    • Author(s)
      Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 1-8

    • DOI

      10.1007/978-1-4939-6430-7_1

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Cell biological assays for measuring chondrogenic activities of CCN proteins2016
    • Author(s)
      Nishida T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Cell Biological Assays for Measuring Angiogenic Activities of CCN Proteins.2016
    • Author(s)
      Shimo T and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 239-249

    • DOI

      10.1007/978-1-4939-6430-7_22

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Western blotting analysis of CCN proteins2016
    • Author(s)
      Kawaki H., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of pathological activities of CCN proteins in bone metastasis2016
    • Author(s)
      Shimo T., Yoshioka N., Takigawa M. and Sasaki A.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of Posttranscriptional Regulation of CCN Genes.2016
    • Author(s)
      Kondo S, Kubota S, and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 187-209

    • DOI

      10.1007/978-1-4939-6430-7_19

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Production of recombinant CCN2 protein by mammalian cells.2016
    • Author(s)
      Nishida, T., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Protocol for measuring angiogenic activities of CCN proteins2016
    • Author(s)
      Shimo T. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Cell Biological Assays for Measuring Chondrogenic Activities of CCN2 Protein.2016
    • Author(s)
      Nishida T, Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 219-237

    • DOI

      10.1007/978-1-4939-6430-7_21

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-alpha expression upon lipopolysaccharide stimulation in human monocytes2016
    • Author(s)
      Murata H, Hattori T, Maeda H, Takashiba S, Takigawa M, Kido J, Nagata T.
    • Journal Title

      J. Periodontal Res.

      Volume: 50 Pages: 452-460

    • DOI

      10.1111/jre.12227

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-26861817, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15H05054

  • [Journal Article] Cell biological assays for measuring chondrogenic activities of CCN2 protein.2016
    • Author(s)
      Nishida, T., Kubota, S., Takigawa, M.
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 未定

    • Data Source
      KAKENHI-PROJECT-26462810

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues.2016
    • Author(s)
      Hara, C., Kubota, S., Nishida, T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H., Takigawa, M.
    • Journal Title

      Mod Rheumatol

      Volume: なし Pages: 1-10

    • DOI

      10.3109/14397595.2016.1155255

    • NAID

      120006358661

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-15K11038

  • [Journal Article] Production of Recombinant CCN2 Protein by Mammalian Cells.2016
    • Author(s)
      Nishida T, Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 95-105

    • DOI

      10.1007/978-1-4939-6430-7_10

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In vitro transfection with and expression of CCN family of genes2016
    • Author(s)
      Janune D. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In vivo evaluation of cartilage regenerative effects of CCN proteins2016
    • Author(s)
      Nishida T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Promoter Analyses of CCN Genes.2016
    • Author(s)
      Eguchi T, Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 177-185

    • DOI

      10.1007/978-1-4939-6430-7_18

    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Generation and analysis of cartilage-specific CCN2 overexpression in transgenic mice2016
    • Author(s)
      Hattori T., Itoh S., and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Protocols for screening for binding partners of CCN proteins: Yeast two- hybrid system2016
    • Author(s)
      Hoshijima M., Hattori T. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Sorcin Expression in the Epiphyseal Growth Plates of Mice2016
    • Author(s)
      Mariko Kawai, Ning Liu, Takako Hattori, Yo-Hei Kataoka, Masaharu Takigawa, Satoshi Kubota, Toshio Yamamoto and Kiyoshi Ohura
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 25(1) Pages: 57-62

    • NAID

      130005119559

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] Production of recombinant CCN family 2 protein in Escherichia. coli.2016
    • Author(s)
      Aoyama E., T. Hattori, S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Real-time PCR analyses of CCN family gene expressions.2016
    • Author(s)
      Kawaki, H., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Analysis of posttranscriptional regulation of CCN genes2016
    • Author(s)
      Kondo S., Kubota S., and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of Transcytosis of CCN2 by Chondrocytes.2016
    • Author(s)
      Kawata K, Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 405-413

    • DOI

      10.1007/978-1-4939-6430-7_33

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues.2016
    • Author(s)
      Hara, C., S. Kubota, T. Nishida, M. Hiasa, T. Hattori, E. Aoyama, Y. Moriyama, H. Kamioka and M. Takigawa.
    • Journal Title

      Mod. Rheumatol.

      Volume: 未定

    • NAID

      120006358661

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Protocols for screening for binding partners of CCN proteins: Yeast two- hybrid system2016
    • Author(s)
      Hoshijima M., Hattori T., and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Protocols for screening peptide motifs binding to CCN family proteins.2016
    • Author(s)
      Kubota, S., H. Kawaki and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Immunohistochemical analyses of CCN proteins.2016
    • Author(s)
      Kawaki, H., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Preparation of module specific antibodies against CCN22016
    • Author(s)
      Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Immunohistochemical Analysis of CCN Proteins in Calcified Tissues.2016
    • Author(s)
      Kawaki H, Kubota K, and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 53-62

    • DOI

      10.1007/978-1-4939-6430-7_6

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Promoter analysis of CCN genes2016
    • Author(s)
      Eguchi T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Protein imaging of CCN2 and CCN3 in living cells2016
    • Author(s)
      Hattori T., Hoshijima M., and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] In vivo evaluation of cartilage regenerative effects of CCN2 protein.2016
    • Author(s)
      Nishida, T., S. Kubota and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Immunohistochemical analysis of CCN proteins2016
    • Author(s)
      Kawaki H., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of transcytosis of CCN2 by chondrocytes2016
    • Author(s)
      Kawata K., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Evaluation of molecular interaction between CCN proteins and its binding partners by surface plasmon resonance (SPR)2016
    • Author(s)
      Aoyama E. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues2016
    • Author(s)
      Hara C., Kubota S., Nishida T., Hiasa M., Hattori T., Aoyama E., Moriyama Y., Kamioka H., Takigawa M.
    • Journal Title

      Mod. Rheumatol.

      Volume: 26 Pages: 1-32

    • NAID

      120006358661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage.2016
    • Author(s)
      Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, Takigawa M.
    • Journal Title

      J Bone Miner Metab

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Journal Article] Protocols for screening peptide motifs binding to CCN proteins2016
    • Author(s)
      Kubota S., Kawaki H. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Analysis of Signaling Pathways Activated by CCN Proteins.2016
    • Author(s)
      Kawaki H, Kubota S, andTakigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 139-143

    • DOI

      10.1007/978-1-4939-6430-7_14

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Preparation of Module-Specific Antibodies Against CCN Family Members.2016
    • Author(s)
      Kubota S and Takigawa M
    • Journal Title

      Methods Mol Biol.

      Volume: 1489 Pages: 115-126

    • DOI

      10.1007/978-1-4939-6430-7_12

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Preparation of module-specific antibodies against CCN family members.2016
    • Author(s)
      Kubota, S. and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Cell biological assays for measuring chondrogenic activities of CCN proteins2016
    • Author(s)
      Nishida T., Kubota S. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Promoter analyses of CCN genes.2016
    • Author(s)
      Eguchi, T., S. Kubota, and M. Takigawa.
    • Journal Title

      Methods in Molecular Biology

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462886

  • [Journal Article] Involvement of multiple CCN family members in platelets that support regeneration of joint tissues2016
    • Author(s)
      Hara C, Kubota S, Nishida T, Hiasa M, Hattori T, Aoyama E, Moriyama Y, Kamioka H, Takigawa M.
    • Journal Title

      Mod Rheumatol.

      Volume: in press

    • NAID

      120006358661

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] Production of recombinant CCN2 protein by mammalian cells.2016
    • Author(s)
      Nishida, T., Kubota, S., Takigawa, M.
    • Journal Title

      Methods in Molecular Biology: CCN Proteins: Methods and Protocols

      Volume: 未定

    • Data Source
      KAKENHI-PROJECT-26462810

  • [Journal Article] The CCN Proteins：An overview2016
    • Author(s)
      Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] Protocols for screening binding partners to CCN proteins: Yeast two hybrid system2016
    • Author(s)
      M. Hoshijima, T. Hattori, M. Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462888

  • [Journal Article] Evaluation of molecular interaction between CCN2 protein and its binding partners by surface plasmon resonance (SPR)2016
    • Author(s)
      Aoyama E. and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26670808

  • [Journal Article] Analysis of signaling pathways activated by CCN proteins2016
    • Author(s)
      Kawaki H., Kubota S., and Takigawa M.
    • Journal Title

      Methods Mol. Biol.

      Volume: 未定

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Journal Article] CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts.2015
    • Author(s)
      Nishida T, Kubota S, Aoyama E, Janune D, Lyons KM, Takigawa M.
    • Journal Title

      J. Biochem.

      Volume: 157(2) Pages: 91-100

    • DOI

      10.1093/jb/mvu056

    • NAID

      40020353020

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-26670808, KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-13F03412

  • [Journal Article] Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification.2015
    • Author(s)
      Khattab　HM, Aoyama E, Kubota S, Takigawa M
    • Journal Title

      J Cell Commun Signal.

      Volume: 未定 Pages: 247-254

    • DOI

      10.1007/s12079-015-0290-x

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-15K11038, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-26670808

  • [Journal Article] CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG.2015
    • Author(s)
      Aoyama E, Kubota S, Khattab HM, Nishida T, Takigawa M.
    • Journal Title

      Bone

      Volume: 73 Pages: 242-248

    • DOI

      10.1016/j.bone.2014.12.058

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25861755, KAKENHI-PROJECT-26670808, KAKENHI-PROJECT-26462810, KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-25462886

  • [Journal Article] Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions2015
    • Author(s)
      Kubota S. and Takigawa M.
    • Journal Title

      Clinical Science

      Volume: 128(3) Pages: 181-196

    • DOI

      10.1042/cs20140264

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-26670808

  • [Journal Article] New functional aspects of CCN2 revealed by trans-omic approaches.2015
    • Author(s)
      Kubota, S., Maeda-Uematsu, A., Nishida, T., Takigawa, M
    • Journal Title

      J. Oral Biosci.

      Volume: 57 Pages: 37-43

    • DOI

      10.1016/j.job.2014.09.002

    • Data Source
      KAKENHI-PROJECT-26462810

  • [Journal Article] Dual pathways to Endochondral osteoblasts: A novel chondrocyte-derived cell identified in hypertrophic cartilage.2015
    • Author(s)
      Hara E. S., Ono M., Hai P. T., Sonoyama W., Kubota S., Takigawa M., Matsumoto T., Young M. F., Olsen B. R., Kuboki T.
    • Journal Title

      Biol Open.

      Volume: 30 Pages: 1585-1596

    • DOI

      10.1242/bio.201411031

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05014, KAKENHI-PROJECT-25462888

  • [Journal Article] Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF-β3 - Associated Chondrogenesis of Bone Marrow - Derived Mesenchymal Stem Cells for Articular Surface Regeneration2015
    • Author(s)
      Emilio Satoshi Hara, Mitsuaki Ono, Pham Thanh Hai, Wataru Sonoyama, Satoshi Kubota, Masaharu Takigawa, Takuya Matsumoto, Marian F. Young, Bjorn R. Olsen, Takuo Kuboki
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 未定 Pages: 1585-1596

    • DOI

      10.1002/jbmr.2502

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-15K20480, KAKENHI-PROJECT-14F04106, KAKENHI-PROJECT-25462886

  • [Journal Article] Terminology of CCN1-6 should not be applicable for their fragments and be limited to only full length CCN1-62015
    • Author(s)
      Takigawa M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 未定 Pages: 81-83

    • DOI

      10.1007/s12079-015-0269-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-15H05014

  • [Journal Article] CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG2015
    • Author(s)
      Eriko Aoyama , Satoshi Kubota , Hany Mohamed Khattab , Takashi Nishida , Masaharu Takigawa
    • Journal Title

      Bone

      Volume: 73 Pages: 242-248

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K11038

  • [Journal Article] Direct interaction between CCN family protein 2 and fibroblast growth factor 1.2014
    • Author(s)
      6)Abd El Kader T, Kubota S, Anno K, Tanaka S, Nishida T, Furumatsu T, Aoyama E, Kuboki T, Takigawa M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 8(2) Pages: 157-163

    • DOI

      10.1007/s12079-014-0232-z

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-26462810

  • [Journal Article] Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma2014
    • Author(s)
      Kondo S, Mukudai Y, Soga D, Nishida T, Takigawa M, Shirota T
    • Journal Title

      Anticancer Res

      Volume: 34(2) Pages: 671-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Journal Article] Report on the 7(th) international workshop on the CCN family of genes2014
    • Author(s)
      Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A.
    • Journal Title

      J Cell Commun Signal

      Volume: 8(1) Pages: 71-6

    • DOI

      10.1007/s12079-014-0227-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Journal Article] Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma.2014
    • Author(s)
      Kondo, S., Mukudai, Y., Soga, D., Nishida, T., Takigawa, M., Shirota, T.
    • Journal Title

      Anticancer Res.

      Volume: 34 Pages: 671-677

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462810

  • [Journal Article] CCN2 as a novel molecule supporting energy metabolism of chondrocytes2014
    • Author(s)
      Maeda-Uematsu, A, Kubota, S., Kawaki, H., Kawata, K., Miyake, Y., Hattori, T., Nishida, T., Moritani, N., Lyons, K.M., Iida, S. and Takigawa. M
    • Journal Title

      J Cell Biochem

      Volume: 115 Pages: 854-865

    • NAID

      120005468290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592216

  • [Journal Article] CCN2 as a novel molecule supporting energy metabolism of chondrocytes2014
    • Author(s)
      Maeda-Uematsu A, Kubota S, Kawaki H, Kawata K, Miyake Y, Hattori T, Nishida T, Moritani N, Lyons KM, Iida S, Takigawa M.
    • Journal Title

      J. Cell Biochem

      Volume: 115 Pages: 854-65

    • DOI

      10.1002/jcb.24728

    • NAID

      120005468290

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23592216, KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-23593014, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-26462810

  • [Journal Article] Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes.2014
    • Author(s)
      Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 8 Pages: 147-156

    • DOI

      10.1007/s12079-014-0220-3

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888

  • [Journal Article] Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: Role of pro-apoptotic Bid2014
    • Author(s)
      Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, Sävendahl L.
    • Journal Title

      Toxicol Lett.

      Volume: 224(2) Pages: 196-200

    • DOI

      10.1016/j.toxlet.2013.10.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Journal Article] Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma.2014
    • Author(s)
      Kondo, S., Mukudai, Y., Soga, D., Nishida, T., Takigawa, M. and Shirota, T.
    • Journal Title

      Anticancer Res., 2014, in press.

      Volume: 34 Pages: 671-677

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732

  • [Journal Article] Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver.2014
    • Author(s)
      Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M, Brigstock DR.
    • Journal Title

      Surgery

      Volume: 156 Pages: 548-555

    • DOI

      10.1016/j.surg.2014.04.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888

  • [Journal Article] The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo2014
    • Author(s)
      Tarek Abd El Kader, et al.
    • Journal Title

      Bone, 59:180-188, 2014.

      Volume: 59 Pages: 180-188

    • DOI

      10.1016/j.bone.2013.11.010

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-13F03412, KAKENHI-PROJECT-14F04106, KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886, KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-26462810

  • [Journal Article] miRNA-720 controls stem cell phenotype, proliferation and differentiation of human dental pulp cells.2013
    • Author(s)
      Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T.
    • Journal Title

      PloS One

      Volume: 8(12) Pages: 1-11

    • DOI

      10.1371/journal.pone.0083545

    • NAID

      120005697278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249064, KAKENHI-PROJECT-22689050, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-24659875

  • [Journal Article] CCN2: a master regulator of the genesis of bone and cartilage2013
    • Author(s)
      Takigawa M.
    • Journal Title

      J Cell Commun Signal

      Volume: 7(3) Pages: 191-201

    • DOI

      10.1007/s12079-013-0204-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Journal Article] Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus2013
    • Author(s)
      Nishida, T., Kubota, S., Aoyama, E. and Takigawa, M.
    • Journal Title

      Osteoarthritis Cartilage.

      Volume: 21 Pages: 700-709

    • DOI

      10.1016/j.joca.2013.01.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415

  • [Journal Article] Cartilage-specific overexpression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth2013
    • Author(s)
      Tomita N, Hattori T, Ito S, Aoyama E, Yao M, Yamashiro T, and Takigawa M
    • Journal Title

      Plos One

      Volume: 8(3)

    • NAID

      120005345532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659872

  • [Journal Article] CCN Family Member 2/Connective Tissue Growth Factor (CCN2/CTGF) Has Anti-Aging Effects That Protect Articular Cartilage from Age-Related Degenerative Changes.2013
    • Author(s)
      Itoh, S., Hattori, T., Tomita, N., Aoyama, E., Yutani,Y., Yamashiro, T., Takigawa, M.
    • Journal Title

      PLoS ONE

      Volume: 8

    • DOI

      10.1371/journal.pone.0071156

    • NAID

      120005345531

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-25862014

  • [Journal Article] Cartilage-specific overexpression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth2013
    • Author(s)
      Tomita, N., Hattori, T., Ito, S., Aoyama, E., Yao, M., Yamashiro, T., Takigawa M.
    • Journal Title

      Plos One

      Volume: 8

    • DOI

      10.1371/journal.pone.0059226

    • NAID

      120005345532

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888, KAKENHI-PROJECT-25862014

  • [Journal Article] Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family2013
    • Author(s)
      Abd El Kader T, Kubota S, Janune D, Nishida T, Hattori T, Aoyama E, Perbal B, Kuboki T, and Takigawa M
    • Journal Title

      Journal of Cell Communication and Signals

      Volume: 7(1) Pages: 11-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249064

  • [Journal Article] E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein.2013
    • Author(s)
      Hattori T, Kishino T, Stephen S, Eberspaecher H, Maki S, Takigawa M, de Crombrugghe B, Yasuda H.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 35138-35148

    • DOI

      10.1074/jbc.m113.486795

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888

  • [Journal Article] Novel role of miR-181a in cartilage metabolism2013
    • Author(s)
      Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Abd El Kader T, Nishida T, Ikeda N, Shimo T, Yamashiro T, Takigawa M
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: in press Pages: 2094-100

    • DOI

      10.1002/jcb.24556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-24593090, KAKENHI-PROJECT-24792282

  • [Journal Article] Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family2013
    • Author(s)
      Abd El Kader, T., Kubota, S., Janune, D., Nishida, T., Hattori, T., Aoyama, E., Perbal, B., Kuboki, T. and Takigawa, M.
    • Journal Title

      J Cell Commun Signal.

      Volume: 7 Pages: 11-18

    • DOI

      10.1007/s12079-012-0180-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462888

  • [Journal Article] CCN2 : A master regulator of the genesis of bone and cartilage2013
    • Author(s)
      Takigawa M
    • Journal Title

      J. Cell Commun. Signal.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Journal Article] Novel chondrogenic and chondroprotective effects of the natural compound harmine2013
    • Author(s)
      Hara, E. S., Ono, M., Kubota, S., Sonoyama, W., Oida, Y., Hattori, T., Nishida, T., Furumatsu, T., Ozaki, T., Takigawa, M. and Kuboki, T
    • Journal Title

      Biochimie

      Volume: 95 Pages: 347-381

    • DOI

      10.1016/j.biochi.2012.10.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-24792142, KAKENHI-PROJECT-25462888

  • [Journal Article] The CCN family acting throughout the body: recent research developments.2013
    • Author(s)
      Kubota S, Takigawa M.
    • Journal Title

      BioMol Concepts

      Volume: 4 Pages: 477-494

    • DOI

      10.1515/bmc-2013-0018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-25462886

  • [Journal Article] Regulation of CCN1 via the 3'-untranslated region2013
    • Author(s)
      Nakagawa, Y., Minato, M., Sumiyoshi, K., Maeda, A., Hara, C., Murase, Y., Nishida, T., Kubota, S. and Takigawa, M.:
    • Journal Title

      Journal of Cell Communication and Signalings.

      Volume: 7 Pages: 207-17

    • DOI

      10.1007/s12079-013-0202-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-24593090, KAKENHI-PROJECT-24792282

  • [Journal Article] Novel chondrogenic and chondroprotec- tive effects of the natural compound harmine2013
    • Author(s)
      Hara ES, Ono M, Kubota S, SonoyamaW, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T
    • Journal Title

      Biochimie

      Volume: 95(2) Pages: 374-381

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249064

  • [Journal Article] Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2interactions in expression of the differentiated phenotype of chondrocytes.2012
    • Author(s)
      Hoshij ima M., et al.
    • Journal Title

      FEBS J.

      Volume: 279(19) Pages: 3584-3597

    • DOI

      10.1111/j.1742-4658.2012.08717.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J04293, KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-24390415

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes.2012
    • Author(s)
      Kawata K, Kubota S, Eguchi T, Aoyama E, Moritani N, Kondo S, Nishida T,and Takigawa M
    • Journal Title

      J Cell Sci

      Volume: 15 Pages: 2965-2972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659872

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1(LRP1) in CCN2/connective tissue growth factor(CTGF) protein transport in chondrocytes.2012
    • Author(s)
      Kawata., K., S. Kubota, T. Eguchi, E. Aoyama, N. Moritani, S. Kondo, T. Nishida and M. Takigawa
    • Journal Title

      J Cell Sci.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes2012
    • Author(s)
      Kawata., K., Kubota, S., Eguchi, T., Aoyama, E., Moritani, N., Kondo, S., Nishida, T., Takigawa, M.
    • Journal Title

      J Cell Sci.

      Volume: 15 Pages: 2965-2972

    • DOI

      10.1242/jcs.101956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-23592922, KAKENHI-PROJECT-23659872, KAKENHI-PROJECT-24390415, KAKENHI-PROJECT-24593060

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1(LRP1) in CCN2/connective tissue growth factor(CTGF) protein transport in chondrocytes.2012
    • Author(s)
      Kawata., K., Kubota, S., (中4名), Nishida, T. and Takigawa, M.
    • Journal Title

      J Cell Sci.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes2012
    • Author(s)
      Hoshijima M, Hattori T, Aoyama E, Nishida T, Yamashiro T, Takigawa M.
    • Journal Title

      FEBS J

      Volume: 279(19) Pages: 3584-3597

    • NAID

      120005311985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659872

  • [Journal Article] Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes2012
    • Author(s)
      Kawata., K., Kubota, S., Eguchi, T., Aoyama, E., Moritani, N., Kondo, S., Nishida, T. and Takigawa, M.
    • Journal Title

      J. Cell Sci.

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659872

  • [Journal Article] Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes.2011
    • Author(s)
      Nishida T, et al
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4232-4241

    • DOI

      10.1210/en.2011-0234

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360, KAKENHI-PROJECT-23592732

  • [Journal Article] Mechanical strech increases CCN2/CTGF expression in anterior cruciate ligament-derived cells.2011
    • Author(s)
      Miyake, Y., (中1名), Kubota, S., (中2名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 409 Pages: 247-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in Ccn2 mRNA.2011
    • Author(s)
      Kondo, S., Kubota, S., Mukudai, Y., Nishida, T.(中3名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 405 Pages: 382-387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes2011
    • Author(s)
      Nishida, T., Kubota, S., (中3名), Takigawa, M.
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4232-4241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells.2011
    • Author(s)
      Miyake, Y., T. Furumatsu, S. Kubota, K. Kawata, T. Ozaki and M. Takigawa.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 409 Pages: 247-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Novel effects of CCN3 That may direct the differentiation of chondrocytes.2011
    • Author(s)
      Janune, D., et al
    • Journal Title

      FEBS Letters

      Volume: 585 Pages: 3033-3033

    • DOI

      10.1016/j.febslet.2011.08.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008, KAKENHI-PROJECT-21592360, KAKENHI-PROJECT-23592732, KAKENHI-PROJECT-23593014

  • [Journal Article] The role of CCN2 in cartilage and bone development.2011
    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      J.Cell Commun.Signal.

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] CCN family 2/connective tissue growth factor(CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein(DC-STAMP)2011
    • Author(s)
      Nishida, T., K. Emura, S. Kubota, K. M. Lyons and M. Takigawa
    • Journal Title

      J Bone Miner Res.

      Volume: 26 Pages: 351-363

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] The role of CCN2 in cartilage and bone development.2011
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 209-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] The role of CCN2 in cartilage and bone development2011
    • Author(s)
      Kubota, S., Takigawa, M.
    • Journal Title

      J Cell Commun Signal

      Volume: 5 Pages: 209-217

    • DOI

      10.1007/s12079-011-0123-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008, KAKENHI-PROJECT-21592360

  • [Journal Article] Binding of glyceraldehyde-3-phosphate dehydrogenase to the cic-acting element of structure-anchored repression in Ccn2 mRNA.2011
    • Author(s)
      Kondo S, Kubota S, Mukudai Y, Nishida T, Yoshihama Y, Shirota T, Shintani S, Takigawa M
    • Journal Title

      Biochem.Biophys.Res.Commun. 405

      Pages: 382-387

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Association of the metastatic phenotype with CCN family members among breast and oral cancer cell.2011
    • Author(s)
      Ohgawara, T., Kubota, S., (中8名), Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 291-299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.2011
    • Author(s)
      Kondo, S., S. Kubota, Y. Mukudai, T. Nishida, Y. Yoshihama, T. Shirota, S. Shintani and M. Takigawa
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 405 Pages: 382-387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Differential roles of CCN family proteins during osteoblast differentiation : involvement of Smad and MAPK signaling pathways2011
    • Author(s)
      EKawaki, H., S. Kubota, A. Suzuki, M. Suzuki, K. Kohsaka, K. Hoshi, T. Fujii, N. Lazar, T. Ohgawara, T. Maeda, B. Perbal, T. Takano-Yamamoto and M. Takigawa.
    • Journal Title

      Bone

      Volume: 49 Pages: 975-989

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] The role of CCN2 in cartilage and bone development2011
    • Author(s)
      Kubota, S., and M. Takigawa.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 209-217

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Effect of CCN2 on FGF2-Induced Proliferation and MMP9 and MMP13 Productions by Chondrocytes2011
    • Author(s)
      Nishida T, Kubota S, Aoyama E, Janune D, Maeda A, Takigawa M
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4232-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659872

  • [Journal Article] CCN family 2/ connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).2011
    • Author(s)
      Nishida T, Emura K, Kubota S, Lyons KM, Takigawa M
    • Journal Title

      J.Bone Miner.Res. 26

      Pages: 351-363

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice.2011
    • Author(s)
      Kodama, T., (中12名), Kubota, S., Takigawa, M., 他6名
    • Journal Title

      J. Clin. Invest.

      Volume: 121 Pages: 3343-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Differential roles of CCN family proteis during osteoblast differentiation : involvement of Smad and MAPK signaling pathways.2011
    • Author(s)
      Kawaki, H., Kubota, S., (中10名), Takigawa, M.
    • Journal Title

      Bone

      Volume: 49 Pages: 975-989

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Association of the metastatic phenotype with CCN family members among breast and oral cancer cells2011
    • Author(s)
      Ohgawara, T., S. Kubota, H. Kawaki, N. Kurio, T. Abd El Kader, M, Hoshijima, D. Janune, T. Shimo, B. Perbal, A. Sasaki and M. Takigawa
    • Journal Title

      J. Cell Commun. Signal

      Volume: 5 Pages: 291-299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] CCN family 2/connective tissue growth factor(CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein(DC-STAMP)2011
    • Author(s)
      Nishida, T., Emura, K., Kubota, S., Lyons, K. M., Takigawa, M.
    • Journal Title

      J. Bone Miner. Res.

      Volume: 26 Pages: 351-363

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] The role of CCN2 in cartilage and bone development.2011
    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      J.Cell Commun.Signal.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads.2011
    • Author(s)
      Janune, D., Kubota, S., (中3名), Takigawa M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 5 Pages: 167-171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Novel effects of CCN3 that may direct the differentiation of chondrocytes.2011
    • Author(s)
      Janune, D., Kubota, S., Nishida, T., (中3名), Takigawa, M.
    • Journal Title

      FEBS Lett.

      Volume: 585 Pages: 3033-3040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice2011
    • Author(s)
      Kodama, T., S. Kubota(14番目), M. Takigawa(15番目: 18名略)
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3343-3356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Effect of CCN2 on FGF2-Induced Proliferation and MMP9 and MMP13 Productions by Chondrocytes2011
    • Author(s)
      Nishida, T., S. Kubota, E. Aoyama, D. Janune, A. Maeda and M. Takigawa
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 4232-4241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Design and utility of CCN2 anchor peptide aptamers.2010
    • Author(s)
      Kawaki, H., Kubota, S., (中5名), Takigawa, M.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 1010-1015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Identification of miR-1 as a micro RNA that supports late stage differentiation of growth cartilage cells.2010
    • Author(s)
      Sumiyoshi K, Kubota S, (中2名), Nishida T, (中2名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 402 Pages: 286-290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Thrombopoietic-mesenchymal interaction that my facilitate both endochondral ossification and platelet maturation via CCN2.2010
    • Author(s)
      Sumiyoshi, K., Kubota, S., (中7名), Takigawa, M.
    • Journal Title

      J. Cell Commun. Signal

      Volume: 4 Pages: 5-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells2010
    • Author(s)
      Sumiyoshi, K., S. Kubota, T. Ohgawara, K. Kawata, T. Nishida, T. Shimo, T. Yamashiro and M. Takigawa.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 402 Pages: 286-290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Nicotine-induced CCN2 : from smoking to periodontal fibrosis.2010
    • Author(s)
      Takeuchi, H., Kubota, S., (中4名), Takigawa, M., Numabe, Y.
    • Journal Title

      J. Dent. Res.

      Volume: 89 Pages: 34-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Design and utility of CCN2 anchor peptide aptamers2010
    • Author(s)
      Kawaki H, S. Kubota, E. Aoyama, N. Fujita, H. Hanagata, A. Miyauchi, K. Nakai and M. Takigawa
    • Journal Title

      Biochimie

      Volume: 92 Pages: 1010-1015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Thrombopoietic-mesenchymal interaction that may facilitate both endochondral ossification and platelet maturation via CCN22010
    • Author(s)
      Sumiyoshi, K., S. Kubota, R. A. Furuta, K. Yasui, E. Aoyama, H. Kawaki, K. Kawata, T. Ohgawara, T. Yamashiro, and M. Takigawa
    • Journal Title

      J Cell Commun Signal.

      Volume: 4 Pages: 5-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] Identification of miR-1 as a micro RNA that supports late stage differentiation of growth cartilage cells.2010
    • Author(s)
      Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Nishida T, Shimo T, Yamashiro T, Takigawa M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 402

      Pages: 286-290

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Nicotine-induced CCN2 : from smoking to periodontal fibrosis.2010
    • Author(s)
      Takeuchi, K., S. Kubota, E. Murakashi, Y. Zhou, K. Endo, P. S. Ng, M. Takigawa, and Y. Numabe.
    • Journal Title

      J. Dent. Res.

      Volume: 89 Pages: 34-39

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] A coading RNA segment that enhances the ribosomal revruitment of chicken Ccn1 mRNA.2010
    • Author(s)
      Mukudai, Y., Kubota, S., (中5名), Takigawa, M.
    • Journal Title

      J. Cell Biochem.

      Volume: 111 Pages: 1607-1618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] N-Terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan2009
    • Author(s)
      Aoyama E., Hattori T., Hoshijima M., Araki D., Nishida T., Kubota S., Takigawa M.
    • Journal Title

      Biochem.J. 420

      Pages: 413-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009
    • Author(s)
      Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.
    • Journal Title

      Biochem J.

      Volume: 420(3) Pages: 413-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Journal Article] CTGF and apoptosis in mouse osteocytes induced by tooth movement.2009
    • Author(s)
      Sakai Y, (中4名), Takigawa M, Takano-Yamamoto T.
    • Journal Title

      J Dent Res.

      Volume: 88(4) Pages: 345-50

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009
    • Author(s)
      Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.
    • Journal Title

      Biochem J. 420(3)

      Pages: 413-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Journal Article] CCN family 2/Connective tissue growth factor(CCN2/CTGF) regulates the expression of Vegf through Hif-1αexpression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.2009
    • Author(s)
      Nishida, T.(中2名), Kubota, S., Lyons, K. M., Takigawa, M.
    • Journal Title

      Bone

      Volume: 44(1) Pages: 24-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family 2/connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1 α expression in a chondrocytic cell line, HCS-2/82009
    • Author(s)
      Nishida, T.S.Kondo, A.Maeda, S.Kubota, K.M.Lyons, and M.Takigawa
    • Journal Title

      under hypoxic condition(Bone) 44

      Pages: 24-31

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells2009
    • Author(s)
      Takeuchi, H., S. Kubota, E. Murakashi, T. Fukada, S. Hashimoto, M. Takigawa and Y. Numabe
    • Journal Title

      J. Perio. Res.

      Volume: 44 Pages: 161-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009
    • Author(s)
      Aoyama E., T.Hattori, M.Hoshijima, D.Araki, T.Nishida, S.Kubota, and M.Takigawa
    • Journal Title

      Biochem. J. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009
    • Author(s)
      Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M
    • Journal Title

      Biochem.J. 420

      Pages: 413-420

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Regulation of chondrocytic phenotype by micro RNA 18a : Involvement of Ccn2/Ctgf as a major target gene2009
    • Author(s)
      Ohgawara, T., S.Kubota, H.Kawaki, S.Kondo, T.Eguchi, N.Kurio, E.Aoyama, A.Sasaki, and M.Takigawa
    • Journal Title

      FEBS Lett 583

      Pages: 1006-1010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009
    • Author(s)
      Aoyama E., T. Hattori, M. Hoshijima, D. Araki, T. Nishida, S. Kubota, and M. Takigawa
    • Journal Title

      Biochem. J.

      Volume: 420 Pages: 413-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592360

  • [Journal Article] CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.2009
    • Author(s)
      Maeda, A., Nishida, T., Aoyama, E., Kubota, S., Lyons, K. M., Kuboki, T., Takigawa, M.
    • Journal Title

      J. Biochem

      Volume: 145(2) Pages: 207-216

    • NAID

      10026301620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.2009
    • Author(s)
      Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T, Takigawa M
    • Journal Title

      J.Biochem. 145

      Pages: 207-216

    • NAID

      10026301620

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells2009
    • Author(s)
      Takeuchi, H., S.Kubota, E.Murakashi, T.Fukada, S.Hashimoto, M.Takigawa and Y.Numabe
    • Journal Title

      J. Perio. Res 44

      Pages: 161-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Regulation of chondrocytic phenotype by micro RNA 18a : Involvement of Ccn2/Ctgf as a major target gene2009
    • Author(s)
      Ohgawara, T., Kubota, S., (中6名), Takigawa, M.
    • Journal Title

      FEBS Lett.

      Volume: 583 Pages: 1006-1010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family 2 /Connective tissue growth factor (CCN2/CTGF) regulates the expression of Vegf through Hif-1a expression in a chondrocytic cell line, HCS-2/8, under hypoxic condition.2009
    • Author(s)
      Nishida T, Kondo S, Maeda A, Kubota S, Lyons KM, Takigawa M
    • Journal Title

      Bone 44

      Pages: 24-31

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Effect of TGF-β1 on CCN2/CTGF in normal human gingival fibroblasts and periodontal ligament cells.2009
    • Author(s)
      Takeuchi, H., Kubota, S., (中3名), Takigawa, M., Numabe, Y.
    • Journal Title

      J. periodontal. Res.

      Volume: 44 Pages: 161-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009
    • Author(s)
      Aoyama, E., Hattori, T., Hoshijima, M., Araki, D., Nishida, T., Kubota, S., Takigawa, M.
    • Journal Title

      Biochem. J.

      Volume: 420 Pages: 413-420

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes2009
    • Author(s)
      Maeda A, T.Nishida, E.Aoyama, S.Kubota, K.M.Lyons, T.Kuboki, and M.Takigawa
    • Journal Title

      J Biochem 145

      Pages: 207-216

    • NAID

      10026301620

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008
    • Author(s)
      Eguchi, T., S.Kubota, K.Kawata, Y.Mukudai, J.Uehara, T.Ohgawara, S.Ibaragi, S.Sasaki, T.Kuboki and M.Takigawa
    • Journal Title

      Mol. Cell. Biol. 28

      Pages: 2391-2413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Promotion of hydroxyapatite-associat -ed, stem cells-based bone regeneration by CCN22008
    • Author(s)
      M. Ono, S. Kubota, T. Fujisawa, W. Sonoyama, H. Kawaki, K. Akiyama, K. Shimono, M. Oshima, T. Nishida, Y. Yoshida, K. Suzuki, M. Takigawa, T. Kuboki
    • Journal Title

      Cell Transplantation 17(1-2)

      Pages: 231-240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17209062

  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.2008
    • Author(s)
      Mukudai, Y., Kubota, S., (中6名), Takigawa, M.
    • Journal Title

      Mol. Cell Biol.

      Volume: 28(19) Pages: 6134-6147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Clinical significance and pathogenic function of connective tissue growth factor(CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.2008
    • Author(s)
      Shimo, T. Kubota, S., (中3名), Nishida, T., Ng, P. S., Endo, K., Takigawa, M. Sasaki, A.
    • Journal Title

      Anticancer Res.

      Volume: 28(4C) Pages: 2343-2348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage2008
    • Author(s)
      Kawaki H., Kubota S., Suzuki A., Lazar N., Yamada, T., Matsumura T., Ohgawara T., Maeda T., Perbal B., Lyons, K. M., Takigawa M.
    • Journal Title

      J.Bone Miner.Res. 23(11)

      Pages: 1751-1764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.2008
    • Author(s)
      Koitabashi N., (中11名), Nishida T., Kubota S., Takigawa M., Kurabayashi M.
    • Journal Title

      Eur. J. Heart Failure

      Volume: 10(4) Pages: 373-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.2008
    • Author(s)
      Kawaki H., Kubota S., (中8名), Takigawa M.
    • Journal Title

      J. Bone Miner. Res.

      Volume: 23(11) Pages: 1751-1764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008
    • Author(s)
      Eguchi T, Kubota S, (中7名), Takigawa M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: 28 Pages: 2391-2413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008
    • Author(s)
      Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., Kawata K., Mitani S., Tabata Y, Ozaki T., Takigawa M.
    • Journal Title

      Tissue Engineering Part A 14(6)

      Pages: 1089-1098

    • NAID

      120005345530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.2008
    • Author(s)
      Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T
    • Journal Title

      Cell Transplantation 17(1-2)

      Pages: 231-240

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure2008
    • Author(s)
      Koitabashi, N., M.Arai, K.Niwano, A.Watanabe, M.Endoh, M.Suguta, T.Yokoyama, H.Tada, T.Toyama, H.Adachi, S.Naito, S.Oshima, T.Nishida, S.Kubota, M.Takigawa and M.Kurabayashi
    • Journal Title

      Eur. J. Heart Failure 10

      Pages: 373-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] CCN family 2/Connective tissue growth factor(CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes2008
    • Author(s)
      Fujisawa T., (中3名), Kubota S., Kuboki T., Takigawa M.
    • Journal Title

      Osteoarthritis and Cartilage

      Volume: 16(7) Pages: 787-795

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family 2 / Connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes2008
    • Author(s)
      Fujisawa T, T.Hattori, M.Ono, J.Uehara, S.Kubota, T.Kuboki and M.Takigawa
    • Journal Title

      Osteoarthritis Cartilage 16

      Pages: 787-795

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008
    • Author(s)
      Ono, M., S.Kubota, T.Fujisawa, W.Sonoyama, H.Kawaki, K.Akiyama, M.Oshima, T.Nishida, Y.Yoshida, K.Suzuki, M.Takigawa and T.Kuboki
    • Journal Title

      Cell Transplant 17

      Pages: 231-240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.2008
    • Author(s)
      Kikuchi T., Kubota S., Asaumi K., Kawaki H., Nishida T., (中4名)、Takigawa M.
    • Journal Title

      Tissue Engineering Part A

      Volume: 14(6) Pages: 1089-1098

    • NAID

      120005345530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation2008
    • Author(s)
      Mukudai, Y., S.Kubota, H.Kawaki, S.Kondo, T.Eguchi, K.Sumiyoshi, T.Ohgawara, T.Shimo, and M.Takigawa
    • Journal Title

      Mol. Cel 1. Biol. 28

      Pages: 6134-6147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration : -Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/82008
    • Author(s)
      Nishida T, Maeda A, Kubota S, Takigawa M
    • Journal Title

      rabbit hyaline costal chondrocytes and meniscus cells- Biorheology 45(3-4)

      Pages: 289-299

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration :-Mechanical stress induces expression of Hcs24/CTGF/CCN2 in human chondrocytic cell line, HCS-2/8, rabbit hyaline costal chondrocytes and meniscus cells2008
    • Author(s)
      Nishida T., Maeda A., Kubota S., Takigawa M.
    • Journal Title

      Biorheology

      Volume: 45(3-4) Pages: 289-299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Novel transcription factor-like function of human MMP3 regulating CTGF/CCN2 gene2008
    • Author(s)
      Eguchi T., Kubota S., Kawata K., Mukudai Y., Uehara J., Ohgawara T., Ibaragi S., Sasaki A., Kuboki T., Takigawa M.
    • Journal Title

      Mol.Cell.Biol. 28

      Pages: 2391-2413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Connective tissue growth factor is overexpressed in muscles of human muscular dystrophy2008
    • Author(s)
      Sun G., (中6名)., Takigawa M., Iinuma K., Tsuchiya S.
    • Journal Title

      J Neurol. Sci.

      Volume: 267(1-2) Pages: 48-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel2008
    • Author(s)
      Kikuchi, T., S.Kubota, K.Asaumi, H.Kawaki, K.Nishida, T., Kawata, S.Mitani, Y.Tabata, T.Ozaki, and M.Takigawa
    • Journal Title

      Tissue Engineering Part A 14

      Pages: 1089-1098

    • NAID

      120005345530

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Clinical significance and function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandible squamous cell carcinoma2008
    • Author(s)
      Shimo, T., S.Kubota, T.Goda, Y.Yoshihama, N.Kurio, T.Nishida, M.Takigawa and A.Sasaki
    • Journal Title

      Anticancer Res. 28

      Pages: 2343-2348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice2008
    • Author(s)
      Kawaki, H., S.Kubota, A.Suzuki, T.Yamada, T.Matsumura, T.Mandai, M.Yao, T.Maeda, K.M.Lyons and M.Takigawa
    • Journal Title

      Biochem. Biophys. Res. Commun 366

      Pages: 450-456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Role of Mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration2008
    • Author(s)
      Nishida, T., A.Maeda, S.Kubota and M.Takigawa
    • Journal Title

      -Mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit hyaline costal chondrocytes and meniscus tissue cells-(Biorheology) 45

      Pages: 289-299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Sasaki A Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.2008
    • Author(s)
      Shimo T, Kubota S, Goda T, Yoshihama Y, Kurio N, Nishida T, Ng PS, Endo K, Takigawa M
    • Journal Title

      Anticancer Res. 28(4C)

      Pages: 2343-2348

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN22008
    • Author(s)
      Ono M., Kubota S., (中5名), Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T.
    • Journal Title

      Cell Transplantation

      Volume: 17(1-2) Pages: 231-240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.2008
    • Author(s)
      Kikuchi T, Kubota S, Asaumi K, Kawaki H, Nishida T, Kawata K, Mitani S, Tabata Y, Ozaki T, Takigawa M
    • Journal Title

      Tissue Engineering Part A 14

      Pages: 1089-1098

    • NAID

      120005345530

    • Data Source
      KAKENHI-PROJECT-20592173

  • [Journal Article] Post-transcriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation2008
    • Author(s)
      Mukudai Y., Kubota S., Kawaki H., Kondo S., Eguchi T., Sumiyoshi K., Ohgawara T., Shimo T., Takigawa M.
    • Journal Title

      Mol.Cell.Biol. 28(19)

      Pages: 6134-6147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 revealed by a comprehensive analysis of the CCN family proteins in cartilage2008
    • Author(s)
      Kawaki, T., S.Kubota, A.Suzuki, N.Lazar, T.Yamada, T.Matsumura, T.Ohgawara, T.Maeda, B.Perbal, K.M.Lyons, and M.Takigawa
    • Journal Title

      J. Bone Miner. Res 23

      Pages: 1751-1764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Functional requirement of CCN2 for intramembranous bone formation in embryonic mice2008
    • Author(s)
      Kawaki H., Kubota S., (中7名), Takigawa M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 366(2) Pages: 450-456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Role of CCN2/CTGF/Hcs24 in Bone Growth.2007
    • Author(s)
      Kubota S., Takigawa M.
    • Journal Title

      Internal.Rev.Cytol. (in press)

    • Data Source
      KAKENHI-PROJECT-16659511

  • [Journal Article] CCN22007
    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      UCSD/Nature Molecular Pages

    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.2007
    • Author(s)
      Eguchi T., Kubota S., (中6名), Takigawa M.
    • Journal Title

      Biochimie

      Volume: 89(3) Pages: 278-288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Role of CCN2/CTGF/Hcs242007
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      bone growth. In Internal Review of Cytology, Vol. 257(K.W.Jeon ed.), Academic Press(Amsterdam)

      Pages: 1-41

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis2007
    • Author(s)
      Koitabashi, N., M.Arai, S.Kogure, K.Niwano, A.Watanabe, Y.Aoki, T.Maeno, T.Nishida, S.Kubota, M.Takigawa and M.Kurabayashi
    • Journal Title

      Hypertension 49

      Pages: 1120-1127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] CCN2(Connective tissue growth factor) is essential for extracellular matrix production and integrin signaling in chondrocytes2007
    • Author(s)
      Nishida T., (中3名)、Takigawa M., Lyons K. M.
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 1 Pages: 45-58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood.2007
    • Author(s)
      Kubota S, Takigawa M
    • Journal Title

      Angiogenesis 10(1)

      Pages: 1-11

    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] Different transcriptional strategies of ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines2007
    • Author(s)
      Eguchi, T., S.Kubota, K.Kawata, Y.Mukudai, T.Ohgawara, K.Miyazono K.Nakao, S.Kondo and M.Takigawa
    • Journal Title

      Biochimie 89

      Pages: 278-288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis.2007
    • Author(s)
      Koitabashi N., (中6名), Nishida T., Kubota S., Takigawa M., Kurabayashi M.
    • Journal Title

      Hypertension

      Volume: 49(5) Pages: 1120-1127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007
    • Author(s)
      Yanagita, T., S.Kubota, K.Kawata, H.Kawaki, S.Kondo, T.Takano-Yamamoto, S.Tanaka and M.Takigawa
    • Journal Title

      FEBS J. 274

      Pages: 1655-1665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood2007
    • Author(s)
      Kubota S., and Takigawa M.
    • Journal Title

      Angiogenesis

      Pages: 101-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] CCN family proteins and angiogenesis : from embryo to adulthood2007
    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Angiogenesis (invited review) 10(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CCN family proteins and angiogenesis: from embryo to adulthood.2007
    • Author(s)
      Kubota, S. and Takigawa, M.
    • Journal Title

      Angiogenesis. 10(1)

      Pages: 1-11

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN2. Biochem2007
    • Author(s)
      Ono, M., S.Kubota, T.Fujisawa, W.Sonoyama, H.Kawaki, K.Akiyama, M.Oshima, T.Nishida, Y.Yoshida, K.Suzuki, M.Takigawa and T.Kuboki
    • Journal Title

      Biophys. Res. Commun 357

      Pages: 20-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes2007
    • Author(s)
      Yanagita T., Kubota S., (中5名), Takigawa M.
    • Journal Title

      FEBS J.

      Volume: 274(7) Pages: 1655-1665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007
    • Author(s)
      M. Ono, S. Kubota, T. Fujisawa, W. Sonoyama, H. Kawaki, K. Akiyama, M. Oshima, T. Nishida, Y. Yoshida, K. Suzuki, M. Takigawa, T. Kuboki
    • Journal Title

      Biochemical and Biophysical Research Communications 357(1)

      Pages: 20-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17209062

  • [Journal Article] A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis2007
    • Author(s)
      Miyamato Y., (中10名), Takigawa M., (他4名)
    • Journal Title

      Nat. Genet.

      Volume: 39 Pages: 529-533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Gene expression and distribution of connective tissue growth factor(CCN2/CTGF) during secondary ossification center formation.2007
    • Author(s)
      Oka M., Kubota S., (中5名)., Takigawa M.
    • Journal Title

      J. Histochem. Cytochem.

      Volume: 55 Pages: 1245-1255

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Promotion of attachment of human bone marrow stromal cells by CCN22007
    • Author(s)
      Ono M., Kubota S., (中5名), Nishida T., Yoshida Y., Suzuki K., Takigawa M., Kuboki T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 357(1) Pages: 20-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Journal Article] Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation2007
    • Author(s)
      Oka, M., S.Kubota, S.Kondo, T.Eguchi, C.Kuroda, K.Kawata, S.Minagi and M.Takigawa
    • Journal Title

      J. Histochem. Cytochem 55

      Pages: 1245-1255

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592142

  • [Journal Article] 軟骨組織の発生分化とCCNファミリー遺伝子2006
    • Author(s)
      久保田 聡、滝川正春
    • Journal Title

      Clin. Calcium 16(3)

      Pages: 486-492

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CCN family genes in the development and differentiation of cartilage tissues2006
    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Clin. Calium (without peer review) 130

      Pages: 486-492

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] 軟骨組織の発生分化とCCNファミリー遺伝子2006
    • Author(s)
      久保田聡, 滝川正春
    • Journal Title

      Clinical Calcium 16

      Pages: 486-492

    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CCNファミリー:その構造と機能。2006
    • Author(s)
      滝川正春
    • Journal Title

      細胞 37

      Pages: 462-465

    • Data Source
      KAKENHI-PROJECT-16659511

  • [Journal Article] CCNファミリー:その構造と機能2005
    • Author(s)
      滝川正春
    • Journal Title

      細胞 37

      Pages: 462-465

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] hBMSC attachment was enhanced by CTGF adsorption in vitro.2005
    • Author(s)
      M.ONO, W.SONOYAMA, K.AKIYAMA, T.FUJISAWA, M.KANYAMA, M.TAKIGAWA, T.KUBOKI
    • Journal Title

      Journal of Dental Research Vol 84, Special Issue A

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] 軟骨組織の発生分化とCCNファミリー遺伝子。2005
    • Author(s)
      久保田聡, 滝川正春
    • Journal Title

      Clinical Calcium 16

      Pages: 486-492

    • Data Source
      KAKENHI-PROJECT-16659511

  • [Journal Article] CCNファミリー:その構造と機能2005
    • Author(s)
      滝川正春
    • Journal Title

      細胞 (印刷中)

    • Data Source
      KAKENHI-PROJECT-16659511

  • [Journal Article] The CCN family : Structures and functions (in Japanese)2005
    • Author(s)
      Takigawa, M
    • Journal Title

      Saibou (without peer review) 34

      Pages: 462-465

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] hBMSC attachment was enhanced by CTGF adsorption in vitro.2005
    • Author(s)
      M ONO, W SONOYAMA, K AKIYAMA, T FUJISAWA, M KANYAMA, M TAKIGAWA, T KUBOKI
    • Journal Title

      Journal of Dental Research Vol.84, Special issue A

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] Roles of CCN2/CTGF2005
    • Author(s)
      Takigawa, M., et. al.
    • Journal Title

      the control of growth and regeneration. In CN Proteins: A New Family of Cell Growth and Differentiation Regulators (Perbal B.& Takigawa M.eds.), Imperial College Press, London

      Pages: 101-128

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CTGF/Hcs24/CCN2 as a regeneration factor("regenerin")acting on various types of mesenchymal cells. In Progress2005
    • Author(s)
      Takigawa, M.
    • Journal Title

      Stem Cell Research(ColumbusF, ed), Nova Science, Hauppauge, NY

      Pages: 19-59

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] hBMSC attachment was enhanced by CTGF adsorption in vitro2005
    • Author(s)
      M ONO, W, SONOYAMA, K AKIYAMA, T FUJISAWA, M KANYAMA, M TAKIGAWA, T KUBOKI
    • Journal Title

      Journal of Dental Research Special issue

    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] CCNファミリー:その構造と機能2005
    • Author(s)
      滝川正春
    • Journal Title

      細胞 (印刷中)

    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CTGF coating enhanced human bone marrow stromal cell attachment in vitro.2004
    • Author(s)
      M ONO, W SONOYAMA, T FUJISAWA, K MAEKAWA, T NISHIDA, Y YOSHIDA, K SUZUKI, M TAKIGAWA. T KUBOKI
    • Journal Title

      Conferences on Orthodontic Advances In Science and Technology Special issue

    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] CCNファミリー2004
    • Author(s)
      滝川正春
    • Journal Title

      Molecular Medicine 41

      Pages: 756-758

    • Data Source
      KAKENHI-PROJECT-16659511

  • [Journal Article] CTGF coating enhanced human bone marrow stromal cell attachment in vitro.2004
    • Author(s)
      M ONO, W SONOYAMA, T FUJISAWA, K MAEKAWA, T NISHIDA, Y YOSHTDA, K SUZUKI, M TAKIGAWA, T KUBOKI
    • Journal Title

      Conferences on Orthodontic Advances In Science and Technology Special issue

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] CTGF coating enhanced human bone marrow stromal cell attachment in vitro.2004
    • Author(s)
      M.ONO, W.SONOYAMA, T.FUJISAWA, K.MAEKAWA, T.NISHIDA, Y.YOSHIDA, K.SUZUKI, M.TAKIGAWA, T.KUBOKI
    • Journal Title

      Conferences on Orthodontic Advances In Science and Technology (Special Issue)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370632

  • [Journal Article] CCNファミリー2004
    • Author(s)
      滝川正春
    • Journal Title

      Molecular Medicine 41

      Pages: 756-758

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CCN family (in Japanese)2004
    • Author(s)
      Takigawa, M
    • Journal Title

      Mol. Med. (without peer review) 41

      Pages: 756-758

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] 成長因子と軟骨細胞2003
    • Author(s)
      久保田聡、滝川正春
    • Journal Title

      腎と骨代謝 16

      Pages: 103-110

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] The role of CTGF/Hcs24/ecogenin in skeletal growth control2003
    • Author(s)
      Takigawa, M., et. al.
    • Journal Title

      J. Cell. Physiol. (invited review) 194

      Pages: 256-266

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Journal Article] Grwoth factors and chondrocytes (in Japanese)2003
    • Author(s)
      Kubota, S., Takigawa, M
    • Journal Title

      Kidney Metab. Bone Dis.(without peer review) 16

      Pages: 103-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15109010

  • [Journal Article] CTGF/Hcs 24 as a multifunctional growth factor for fibroblasts, chondrocytes, and vascular endothelial cells2003
    • Author(s)
      Takigawa, M
    • Journal Title

      Drug News Perspect.(invited review) 16

      Pages: 11-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Journal Article] CTGF/Hcs 24 as a multifunctional growth factor for fibroblasts, chondrocytes, and vascular endothelial cells.2003
    • Author(s)
      Masaharu Takigawa
    • Journal Title

      Drug News Perspect. (invited review) 56

      Pages: 27-28

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Journal Article] The role of CTGF/Hcs24/ecogenin in skeletal growth control.2003
    • Author(s)
      Masaharu Takigawa, et. al.
    • Journal Title

      J. Cell. Physiol (invited review). 194

      Pages: 256-266

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307053

  • [Patent] がんの治療又は予防剤2015
    • Inventor(s)
      滝川正春他
    • Industrial Property Rights Holder
      日本製粉株式会社、岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015
    • Acquisition Date
      2017
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Patent] 癌の予防または治療剤2015
    • Inventor(s)
      滝川正春他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-14
    • Data Source
      KAKENHI-PROJECT-15H05014

  • [Patent] 癌の治療又は予防剤2013
    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2013-01-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Patent] 癌の治療又は予防剤2013
    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学/日本製粉
    • Industrial Property Number
      2013-006973
    • Filing Date
      2013-01-23
    • Data Source
      KAKENHI-PROJECT-24390415

  • [Patent] がんの治療又は予防剤2012
    • Inventor(s)
      滝川正春、服部高子、他
    • Industrial Property Rights Holder
      滝川正春、服部高子、他
    • Filing Date
      2012-01-12
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Patent] がんの治療又は予防剤2012
    • Inventor(s)
      滝川正春、服部高子, 他
    • Industrial Property Rights Holder
      滝川正春、服部高子, 他
    • Filing Date
      2012-01-20
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Patent] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012
    • Inventor(s)
      滝川正春、服部高子、他
    • Industrial Property Rights Holder
      滝川正春、服部高子、他
    • Filing Date
      2012-01-12
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Patent] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012
    • Inventor(s)
      滝川正春、服部高子, 他
    • Industrial Property Rights Holder
      滝川正春、服部高子, 他
    • Filing Date
      2012-01-20
    • Data Source
      KAKENHI-PROJECT-21592359

  • [Patent] がんの治療又は予防剤2012
    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009665
    • Filing Date
      2012-01-20
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Patent] 癌の治療又は予防剤2012
    • Inventor(s)
      滝川正春、服部高子他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009665
    • Filing Date
      2012-01-20
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Patent] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012
    • Inventor(s)
      滝川正春, 他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2012-009688
    • Filing Date
      2012-01-20
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Patent] 軟骨再生促進剤2010
    • Inventor(s)
      窪木拓男、滝川正春他
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2011-037932
    • Filing Date
      2010-02-24
    • Data Source
      KAKENHI-PROJECT-19109008

  • [Presentation] 変形性股関節症とCCN3発現の相関2022
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、久保田聡、尾崎敏文
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞におけるGDF5とCCN2との結合の意義2022
    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾崎敏文、滝川正春
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 軟骨細胞における転写因子RFX1を介したCCN3の発現制御機構とその役割2022
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 軟骨細胞におけるGDF5とCCN2との結合の意義2022
    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾崎敏文、滝川正春
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 変形性股関節症とCCN3発現の相関2022
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、久保田聡、尾崎敏文
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、 飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細胞におけるGDF5とCCN2との結合の意義2022
    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾崎敏文、滝川正春
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞における転写因子RFX１を介したCCN3の発現制御機構とその役割2022
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池菫、川木晴美、滝川正春、上岡寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞におけるGDF5とCCN2との結合の意義2022
    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾崎敏文、滝川正春
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨代謝研究の過去40年と将来展望2022
    • Author(s)
      滝川　正春
    • Organizer
      第34回日本軟骨代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺　翔太、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、 飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、 飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 軟骨細胞における転写因子RFX1を介したCCN3の発現制御機構とその役割2022
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細胞における転写因子RFX1を介したCCN3の発現制御機構とその役割2022
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 軟骨代謝研究の過去40年と将来展望2022
    • Author(s)
      滝川　正春
    • Organizer
      第34回日本軟骨代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 変形性股関節症とCCN3発現の相関2022
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、 久保田聡、尾崎敏文
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 変形性股関節症とCCN3発現の相関2022
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、 久保田聡、尾崎敏文
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細胞における転写因子RFX１を介したCCN3の発現制御機構とその役割2022
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池菫、川木晴美、滝川正春、上岡寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺　翔太、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] C型レクチン様受容体CD302の骨芽細胞における発現と機能2021
    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] Chondrocyte differentiation is positively regulated by S-adenosyl- methionine via polyamine biosynthesis2021
    • Author(s)
      Hoang Dinh, L., Aoyama, E., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] Expression and function of C-type lectin CD302 in osteoblasts C型レクチン様受容体CD302の骨芽細胞における発現と機能2021
    • Author(s)
      Eriko Aoyama, Satoshi Kubota, Masaharu Takigawa
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19K10053

  • [Presentation] 変形性肩関節症モデルとしてのCCN3過剰発現マウス2021
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] S-adenosylmethionine positively modulates differentiation in chondrocytes via polyamine biosynthesis2021
    • Author(s)
      Hoang Dinh, L., Aoyama, E., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] メトホルミンの軟骨細胞におけるUCA1誘導をともなった分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] CCN3は関節軟骨の加齢性変性を促進する2021
    • Author(s)
      桑原実穂、武内聡子、近藤　星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] メトホルミンのUCA1誘導および軟骨細胞分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細解糖阻害剤NaFの線維化抑制効果とCCNファミリー遺伝子の関与2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、堀　彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 軟骨細胞における解糖系によるCCN3遺伝子発現制御メカニズム。2021
    • Author(s)
      水川朋美、西田　崇、明石　翔、上岡　寛、滝川正春、久保田聡
    • Organizer
      第33回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 骨芽細胞におけるCD302の発現と機能2021
    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞への作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細解糖阻害剤NaFの線維化抑制効果とCCNファミリー遺伝子の関与2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、堀　彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] Cellular Communication Network factor 6 (CCN6)のEMT 及び破骨細胞形成に対する抑制作用2021
    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021
    • Author(s)
      河田　かずみ、青山 絵理子、滝川　正春、久保田　聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K10109

  • [Presentation] Cellular Communication Network factor 6 (CCN6)のEMT 及び破骨細胞形成に対する抑制作用2021
    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] メトホルミンの軟骨細胞におけるUCA1誘導をともなった分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] 軟骨細胞老化促進因子としてのCCN32021
    • Author(s)
      桑原実穂、武内聡子、近藤 星、Fu Shanqi、大野充昭、古松毅之、中田英二、 滝川正春、久保田聡、服部高子
    • Organizer
      第33回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19K22716

  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] ヒト骨格形成細胞分化におけるurothelial cancer-associated 1(UCA1)長鎖ノンコーディングRNAの生理的役割2021
    • Author(s)
      石川崇典、西田 崇、大野充昭、宝田剛志、Ha Thi Thu Nguyen, 栗原慎之介、古松毅之、 村瀬友里香、滝川正春、大橋俊孝、上岡 寛、久保田聡
    • Organizer
      第33回日本軟骨代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K22716

  • [Presentation] 変形性肩関節症モデルとしてのCCN3過剰発現マウス2021
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、 久保田聡、尾崎敏文
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] non-coding RNAを介したメトホルミンの抗線維化作用の解析2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第75回日本口腔科学会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 軟骨細解糖阻害剤NaFの線維化抑制効果とCCNファミリー遺伝子の関与2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、堀　彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] メトホルミンの軟骨細胞におけるUCA1誘導をともなった分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] メトホルミンの軟骨細胞分化促進作用におけるUCA1とCCN2の役割2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] メトホルミンによるUCA1を介した軟骨保護作用の解析2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、 飯田征二、滝川正春、久保田聡
    • Organizer
      第42回岡山歯学会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] CCN3は関節軟骨の加齢変性を促進する2021
    • Author(s)
      桑原実穂、武内聡子、近藤　星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細解糖阻害剤NaFの線維化抑制効果とCCNファミリー遺伝子の関与2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、堀　彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 変形性肩関節症とCCN3発現上昇の相関について2021
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、久保田聡、尾崎敏文
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] Cellular Communication Network factor 6 (CCN6)のEMT 及び破骨細胞形成に対する抑制作用2021
    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] S-アデノシルメチオニンによる軟骨細胞分化促進作用とそのメカニズムの解析 S-adenosylmethionine positively modulates differentiation in chondrocytes via polyamine biosynthesis2021
    • Author(s)
      Loc Hoang Dinh, Eriko Aoyama, Satoshi Kubota, TakuoKuboki, Masaharu Takigawa
    • Organizer
      第39回日本骨代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K10053

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与.2021
    • Author(s)
      河田　かずみ、青山 絵理子、滝川　正春、久保田　聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K10109

  • [Presentation] 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞における解糖系によるCCN3遺伝子発現制御メカニズム2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、上岡 寛、滝川正春、久保田聡
    • Organizer
      第33回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19K22716

  • [Presentation] 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム。2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞における生物学的作用へのHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] メトホルミンの軟骨細胞におけるUCA1誘導をともなった分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] メトホルミンのUCA1誘導および軟骨細胞分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] 変形性肩関節症モデルとしてのCCN3過剰発現マウス2021
    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、 久保田聡、尾崎敏文
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] メトホルミンのUCA1誘導および軟骨細胞分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞における生物学的作用へのHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] メトホルミンのUCA1誘導および軟骨細胞分化促進作用2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] メトホルミンの軟骨細胞分化促進作用におけるUCA1とCCN2の役割2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-20K20611

  • [Presentation] 軟骨細胞における解糖系によるCCN3遺伝子発現制御メカニズム2021
    • Author(s)
      水川朋美、西田　崇、明石　翔、上岡　寛、滝川正春、久保田聡
    • Organizer
      第33回日本軟骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞における生物学的作用へのHippo pathwayの関与2021
    • Author(s)
      河田　かずみ、青山 絵理子、滝川　正春、久保田　聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Data Source
      KAKENHI-PROJECT-19K10109

  • [Presentation] Chondrocyte differentiation is positively regulated by S-adenosyl- methionine via polyamine biosynthesis.2021
    • Author(s)
      Hoang Dinh, L., Aoyama, E., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] メトホルミンによるUCA1を介した軟骨保護作用の解析2021
    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、 飯田征二、滝川正春、久保田聡
    • Organizer
      第42回岡山歯学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞への作用におけるHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Data Source
      KAKENHI-PROJECT-21K19603

  • [Presentation] フッ化ナトリウムによるCCNファミリー遺伝子制御を介した歯肉線維化抑制作用の検討2021
    • Author(s)
      水川朋美、西田 崇、明石 翔、大杉綾花、大森一弘、中山真彰、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第42回岡山歯学会
    • Data Source
      KAKENHI-PROJECT-21H03105

  • [Presentation] CCN6の破骨細胞形成における阻害作用。2021
    • Author(s)
      西田　崇、芳地浩彰、青山絵理子、滝川正春、久保田聡
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-20K09889

  • [Presentation] CCN6の破骨細胞形成における阻害作用2021
    • Author(s)
      西田　崇、芳地浩彰、青山絵理子、滝川正春、久保田聡
    • Organizer
      第39回日本骨代謝学会
    • Data Source
      KAKENHI-PROJECT-19H03817

  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞における生物学的作用へのHippo pathwayの関与2021
    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会