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TANAKA Noriaki  田中 紀章

ORCIDConnect your ORCID iD *help
Researcher Number 10127566
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2010: 岡山大学, 大学院・医歯薬学総合研究科, 教授
2005 – 2008: Okayama University, Graduate School of Medicine. Dentistry and Pharmaceutical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授
2006: Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sdences, Professor, 大学院医歯薬学総合研究科, 教授
2001 – 2004: Okayama University, Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授
1999 – 2001: 岡山大学, 医学部, 教授 … More
1996 – 1997: 岡山大学, 医学部, 教授
1994 – 1995: 岡山大学, 医学部, 助教授
1987: 岡山大学, 医学部・附属病院, 講師
1987: Okayama University Medical School, First Department of Surgery Assistant Profess, 医学部附属病院, 講師
1986: Assistant Prof., Hospital of Okayama University Medical School, 医学部, 講師
1986: 岡山大学, 医学部付属病院, 講師
1984: Okayama University Medical School, First Department of Surgery Instructor, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
General surgery / General surgery / Thoracic surgery / Digestive surgery / Digestive surgery
Except Principal Investigator
General surgery / Digestive surgery / Digestive surgery / Thoracic surgery / Pathological medical chemistry / Functional basic dentistry / Laboratory medicine / Gastroenterology
Keywords
Principal Investigator
E2F-4 / Colon cancer / 大腸癌 / microsatellite instability / genetic instability / ODC / MSH3 / chemosensitivity / p21 / gastroenterological cancer … More / carcinogenesis / genetic alteration / epigenetic alteration / colorectal cancer / gastric cancer / esophageal cancer / lymphokine activated killer / 人工臓器学 / ヒトES細胞 / 細胞・組織 / 再生医学 / 移植・再生医療 / バイオテクノロジー / 国際情報交換 / アメリカ / 胸膜中皮腫 / CRI1 / Bid / E1A / 制限増殖型アデノウイルス / 中皮腫 / プロモータ / 臓器移植 / 免疫寛容 / 門脈内投与 / 経口トレランス / Kupffer細胞 / 移植免疫 / microchimerism / キメリズム / 白血球 / ノイラミニダーゼ / 門脈内注入 / ラット / Transplantation / Tolerance / Portal venous / Liver / Kupffer cell / 癌化機構 / 遺伝子不安定性 / qenetic instability / 点突然変異 / DNA修復異常 / 化学療法 / colon cancer / 可逆性不死化 / ヒト肝細胞株 / ヒト肝内皮細胞株 / バイオ人工肝臓 / ブタ肝細胞分離 / 不死化肝細胞 / テロメレース / ブタ肝不全 / reversible immortalization / human hepatocyte cell line / human liver endothelial cell line / bioartificial liver / porcine hepatocyte isolation / ヒト骨髄間葉系幹細胞 / 骨細胞 / 脂肪細胞 / 軟骨細胞 / レンチウイルスベクター / マウスES細胞 / 骨髄間葉系幹細胞 / HGF / human bone marrow mesenchymal stem cells / osteocyte / adipocyte / chondrocyte / lentiviral vector / mouse embryonic stem cells / 消化器癌 / 発癌機構 / 後成変異 / 突然変異 / 食道癌 / 潰瘍性大腸炎 / 癌 / 遺伝子 / 臨床応用 / 部分肝切除 / 再生肝細胞 / 肝非実質細胞 / IL-2産生能 / 摘脾 / partial hepatectomy / regenerating liver cells / nonparenchymal liver cells … More
Except Principal Investigator
microsatellite instability / 大腸癌 / genetic instability / E2F-4 / epigenetic alteration / Surfactant protein A / ヘパラナーゼ / 転移 / 浸潤 / heparanase / invasion / carcinogenesis / colorectal cancer / スクリーニング / TTF1 / 肺癌 / Thyriod transcription factor 1 / グルココルチコイド / Thyroid transcription factor 1 / メチル化 / Colon cancer / MSH3 / pancreatic cancer / serum DNA / polymorphism / choemoterapy / 小腸移植 / 門脈内注入 / 免疫抑制 / NF-κB / TNF / IFN-α / Fas / 分化 / metastasis / gastroenterological cancer / genetic alteration / gastric cancer / esophageal cancer / COX-2 / 血管新生 / BRAF / LAK細胞 / インターロイキン2 / ノイラミニダーゼ / LAK cell / interleukin 2 / neuraminidase / FK506 / 可逆性不死化細胞 / ヒト肝細胞 / プロテオーム解析 / 質量分析計 / 不死化機構 / 間葉系幹細胞 / 発現プロファイル / 骨芽細胞 / 再生医療 / 軟骨細胞 / テロメラーゼ / DNAチップ / 脂肪細胞 / 再生治療 / DNAメチル化 / 消化器癌 / 早期診断 / surfactant protein / non small cell lung cancer / adenovirus / KRas / intratracheal administration / cisplatin / 制限増殖アデノウイルス / 肺胞サーファクタント / 進行肺癌 / 腫瘍検査学 / 便潜血反応 / 検便 / 癌 / ゲノム / トランスレーショナルリサーチ / 遺伝子 / 臨床 / 体外循環システム / 抗腫瘍性キラーリンパ球 / レクチン固定セファロース粒子 / 腫瘍壊死因子 / スフェロイド / 人工肝臓 / 循環培養 / 肝不全 / アンモニア除去 / ブタ / 肝細胞スフェロイド / アルブミン産生 / アンモニア処理能 / 急性肝不全 / 尿素合成 / 劇症肝炎 / 連続培養 / Spheroid / Artificail liver support / Circulating culture / Liver failure / Serum ammonia level / Pig / DNA修復異常 / CAG繰り返し配列 / ornihine decarboxylase (0DC) / 癌悪性化機構 / 遺伝子不安定化 / 遺伝子複製異常 / LOH / 膵癌 / 血漿 / DNA / 末梢血 / plasma / peripheral blood / LOII / microsatellite inslability / 移植臓器保存 / 過冷却保存 / 冷保存傷害 / 抗凍結性蛋白 / アスコルビン酸 / subzero nonfreezing preservation / anti-nucleating protein / ascorbic acid 2-glucoside / liver transplantation / 肝移植 / 臓器保存 / 抗氷晶核蛋白 / 過冷却 / 類洞内皮細胞 / ascorbic acid-2-glucoside / transplant organ storage / supercooling preservation / cold preservation injury / anti-freezing protein / ascorbic acid / drug sensitivity / 化学療法 / drug sensitivitv / サイトカインクロストーク / アポトーシス / NF-kB / TNF-α / cytokine cross-talk / apoptosis / 移植 / 門脈内投与 / ラット / 小腸 / transplantation / Immunosuppression / intraportal injection / rat / small intestine / 悪性度 / gastic cancer / esophagealcancer / colon cancer / malignant degree / epigenetics / methylation / promoter / gastrointestinal neoplasia / DNA repair / epitenetics / gastrointestinal neoplasea / repair / anaiogenesis / 発癌 / 遺伝子診断 / エピジェネティックス / マイクロサテライト不安定性 / 遺伝子解析 / genetic diagnosis / eni genetics / マトリックス / ペパラナーゼ / 乳癌 / 胃癌 / angiogenesis / differentiation / Thyroid transcription factor / プロモータ / 肺胞サーファクタントプロティンA / hTERT / Gefitinib / 遺伝子治療 / Lung cancer / Glucocorticoid / IL-2徐放製剤 / 転移性肝癌 / インドメサシン / IL-2 slow delivery system / metastatic liver cancer / indomethacin / 肝再生 / NK細胞 / サイクロスポリンA / 肝硬変 / 肝部分切除 / 活性化キラー細胞 / ILー2 / 抗腫瘍活性 / 部分肝切除 / 肝癌 / 特異的キラーTリンパ球 / 非特異的キラーリンパ球 / hepatic regeneration / NK cell / cyclosporine A / liver cirrhosis Less
  • Research Projects

    (30 results)
  • Research Products

    (84 results)
  • Co-Researchers

    (52 People)
  •  Targeting advanced non small cell lung cancer in vivo by pulmonary surfactant -adenovirus-mediated gene transfer

    • Principal Investigator
      MATSUOKA Jyunji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Okayama University
  •  Development of Non-invasive Screening Tool to Detect Colorectal Neoplasia.

    • Principal Investigator
      NAGASAKA Takeshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Okayama University
  •  Hepatic differentiation of human embryonic stem cells and its application to the development of a bioartificial liver systemPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Development of epigenetic biomarker for early diagnosis of gastrointestinal cancer

    • Principal Investigator
      MATSUBARA Nagahide
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  第三世代制限増殖ウイルスベクターを用いた瀰漫性胸膜中皮腫に対する新規治療法の開発Principal Investigator

    • Principal Investigator
      田中 紀章
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Thoracic surgery
    • Research Institution
      Okayama University
  •  Functional Analysis of Heparanase-Development of Therapeutic Modalities for Antiangiogenesis and Defferentiation-

    • Principal Investigator
      NAOMOTO Yoshio
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  HUMAN NON-SMALL CELLLUNG CANCER TARGETED PROMOTER SYSTEM FOR GENE THERAPY

    • Principal Investigator
      MATSUOKA Junji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Okayama University
  •  Elucidation, of the interacting mechanism between epigenetic and genetic alterations in gastrointestinal cancers and of the possible application to the clinicPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  Investigation of colorectal carcinogenesis for genetic diagnosis

    • Principal Investigator
      KAMBARA Takeshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  Inhibition of cancer invasion and metastasis targeting heparanase

    • Principal Investigator
      NAOMOTO Yoshio
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用

    • Principal Investigator
      大山 和美, NAKANISHI Toru
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Okayama University
  •  Development of Regenerative Medicine Using Reversibly Proliferating Human Bone Marrow Mesenchymal Stem CellsPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Elucidation of new molecular mechanism of cancer caused by gene promoter methylation and its clinical aplication

    • Principal Investigator
      MATSUBARA Nagahide
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      OKAYAMA UNIVERSITY
  •  可逆性不死化ヒト肝細胞を用いたプロテオーム解析による不死化機構の研究

    • Principal Investigator
      米澤 一仁
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kobe University
  •  Bioartificial liver development using reversibly immortalized human liver cell lines.Principal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Study of the mechanisms of the induction of hyporesponsiveness by intraportal infusion of donor cells by using GFP rats

    • Principal Investigator
      MATSUOKA Junji
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      OKAYAMA UNIVERSITY
  •  The analysis of the role and inhibition of heparanase in cancer metastasis and inflammation

    • Principal Investigator
      NAOMOTO Yoshio
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      OKAYAMA UNIVERSITY
  •  Development of the supercooling preservation method for transplant liver graft and analysis of the mechanism of cold preservation injury

    • Principal Investigator
      YAGI Takahito
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Drug Polymorphic triple nucleotide alterations in cell cycle transactivator E2F-4 and sensitivity to the anlicancer agents

    • Principal Investigator
      MATSUBARA Nagahide
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University Hospital
  •  NF-κ B mediated apoptosis induced by TNF/IFN-α

    • Principal Investigator
      HAISA Minoru
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University Hospital
  •  Cell cycle transactivation factor E2F-4 is associate with the ganstrointestinal carcinogenesis and/or acquisition of chemoresistancePrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  Genetic diagnosis of gastrointestinal cancer using peripheral blood DNA or ascitis DNA

    • Principal Investigator
      ISOZAKI Hiroshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Okayama University
  •  Role of ornithine decarboxylase (ODC) as a oncogene in colorectal tumorigenesisPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Development of bioartificial liver support utilizing hepatocyte spheroids and its evaluation on pigs with liver failure.

    • Principal Investigator
      KOIDE Norio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Okayama University
  •  Association of gastrointestinal cancer progression and the alteration of cancer related genes.

    • Principal Investigator
      GOUCHI Akira
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  THE IMMUNOLOGICAL HYPORESPONSIVENESS AND DONOR CELL PERSISTENCE IN HOST LIVER AFER PORTAL VENOUS INNOCULATIONPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  体外循環システムによる抗腫瘍性リンパ球の誘導と癌治療の試み

    • Principal Investigator
      ORITA Kunzo
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Activation of anti-tumor immunity during hepatic regeneration and the activation mechanism

    • Principal Investigator
      ORITA Kunzo
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Studies on the functions of the actirated lymphocytes after partial hepatectomyPrincipal Investigator

    • Principal Investigator
      TANAKA Noriaki
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Okayama University
  •  Induction of nonspecific cytotoxic lymphocyte against cancer by interleukin 2, and the application for cancer therapy

    • Principal Investigator
      ORITA Kunzo
    • Project Period (FY)
      1983 – 1984
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Okayama University

All 2010 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation Patent

  • [Journal Article] 便中メチル化DNA検出による消化器がんスクリーニング:消化器がんを非侵襲的にスクリーニングすることは可能か?2010

    • Author(s)
      永坂岳司, 田中紀章, 孫冬生, 猶本良夫, 松原長秀, 八木孝仁, 藤原俊義
    • Journal Title

      岡山医学会雑誌 第122巻

      Pages: 107-112

    • NAID

      130004505681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590572
  • [Journal Article] Targeting KRAS Mutation-bearing Lung Cancer In Vivo by Pulmonary Surfactant-Adenovirus-mediated Gene Transfer.2010

    • Author(s)
      Fukazawa T, Maeda Y, Matsuoka J, Ono T, Mominoki K, Yamatsuji T, Shigemitsu K, Morita I, Murakami I, Tanaka H, Durbin ML, Naomoto Y.
    • Journal Title

      Anticancer Research. 125

      Pages: 4925-4935

    • Data Source
      KAKENHI-PROJECT-20390369
  • [Journal Article] Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.2009

    • Author(s)
      Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland CR, Matsubara N, Goel A.
    • Journal Title

      J Natl Cancer Inst. 101(18)

      Pages: 1244-1258

    • NAID

      130004505681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590572
  • [Journal Article] Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.2009

    • Author(s)
      Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, et al.
    • Journal Title

      Journal of the National Cancer Institute 101(18)

      Pages: 1244-1258

    • NAID

      130004505681

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590572
  • [Journal Article] Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system.2009

    • Author(s)
      Fukazawa T, Matsuoka J, Tanaka N, Tanaka H, Durbin ML Maeda Y, Naomoto Y.
    • Journal Title

      Int J Cancer. 125

      Pages: 1975-1984

    • Data Source
      KAKENHI-PROJECT-20390369
  • [Journal Article] Mutations in both KRAS and BRAF contribute to the methylator phenotype in colon cancer. 134 : 1950-1960 (2008)2008

    • Author(s)
      Nagasaka T. Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin S-K, Sasamoto H, Tanaka N, Matsubara N, Bol, C R, Goel A
    • Journal Title

      Gastroenterology 134

      Pages: 1950-1960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Methylation pattern of the 06-methylguanlne一DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. 122 : 2429-2436 (2008)2008

    • Author(s)
      Nagasaka T, Goel Ajay, KenjiNotohara, Takaomi Takahata, Hiromi Sasamoto, Takuyuki Uchida, NaoshiNishida, Noriaki Tanaka, C. Richard Boland, Nagahide Matsubara
    • Journal Title

      Int. J. Cancer 122

      Pages: 2429-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Malignant Pleural Mesothelioma-Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy2008

    • Author(s)
      Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yutaka Maeda, Mary Durbin, Noriaki Tanaka
    • Journal Title

      Cancer Research 68

      Pages: 7120-7129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659353
  • [Journal Article] Methylation pattern of the 06-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.2008

    • Author(s)
      Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N
    • Journal Title

      Int J Cancer. 122(11)

      Pages: 2429-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590572
  • [Journal Article] Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis2008

    • Author(s)
      Takeshi Nagasaka, Ajay Goel, Kenji Notohara, Takaomi Takahata, Hiromi Sasamoto, Takuyuki Uchida, Naoshi Nishida, Noriaki Tanaka, C. Richard Boland, Nagahide Matsubara
    • Journal Title

      Int. J. Cancer 122

      Pages: 2429-2436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer.2008

    • Author(s)
      Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, Boland CR, Goel A.
    • Journal Title

      Gastroenterology. 134(7)

      Pages: 1950-1960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590572
  • [Journal Article] Mutations in both KRAS and BRAF contribute to the methylator phenotype in colon cancer2008

    • Author(s)
      Takeshi Nagasaka, Minoru Koi, Matthias Kloor, Johannes Gebert, Alex Vilkin, Naoshi Nishida, Sung Kwan Shin, Hiromi Sasamoto, Noriaki Tanaka, Nagahide Matsubara, C. Richard Boland, and Ajay Goel
    • Journal Title

      Gastroenterology 134

      Pages: 1950-1960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa.2007

    • Author(s)
      Ishii, T., Murakami, J., Notohara, K., Cullings, H.M., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, J.R., Matsubara.N
    • Journal Title

      Gut 56

      Pages: 13-19

    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Translocation of heparanase into nucleus results in cell differentiation2007

    • Author(s)
      Nobuhisa, T., Naomoto, Y., Okawa, T., Takaoka, M., Gunduz, M., Motoki, T., Nagatsuka, H.,Tsujigiwa, H., Shirakawa, Y., Yamatsuji, T., Haisa, M., Matsuoka, J., Kurebayashi, J.,Nakajima, M., Taniguchi, S., Sagara, J., Dong, J., Tanaka, N
    • Journal Title

      Cancer Sci 98 (4)

      Pages: 535-540

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Heparanase promotes angiogenesis through Cox-2 and HIFlalpha2007

    • Author(s)
      Naomoto, Y., Gunduz, M., Takaoka, M., Okawa, T., Gunduz, E., Nobuhisa, T., Kobayashi, M.,Shirakawa, Y., Yamatsuji, T., Sonoda, R., Matsuoka, J., Tanaka, N
    • Journal Title

      Med Hypotheses 68 (1)

      Pages: 162-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa.2007

    • Author(s)
      Ishii, T., Murakami, J., Notohara, K., Cullings, H.M., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, J.R., Matsubara, N.
    • Journal Title

      Gut 56

      Pages: 13-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Pulmonary adenocarcinoma-targeted gene therapy by a cancer- and tissue-specific promoter system2007

    • Author(s)
      Fukazawa T, Maeda Y, Durbin ML, Nakai T, Matsuoka J, Tanaka H, Naomoto Y, Tanaka N.
    • Journal Title

      Molecular and Cancer Therapeutics 6巻・1号

      Pages: 244-252

    • Data Source
      KAKENHI-PROJECT-18591548
  • [Journal Article] Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa2007

    • Author(s)
      Ishii, T., Murakami, J., Notohara, K., Cullings, H. M., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, J. R., Matsubara, N.
    • Journal Title

      Gut 56 13-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis (2007)2007

    • Author(s)
      Takeshi Nagasaka, Ajay Goel, Kenji Notohara, Takaomi Takahata, Hiromi Sasamoto, Takuyuki Uchida, Naoshi Nishida, Noriaki Tanaka, C. Richard Boland, Nagahide Matsubara
    • Journal Title

      Int. J. Cancer (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa2007

    • Author(s)
      Ishii, T., Murakami, J., Notohara, K., Cullings, HM., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, JR., Matsubara, N
    • Journal Title

      Gut 56 (1)

      Pages: 13-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oralcancer cell lines.2007

    • Author(s)
      Murakami J, Lee YJ, Kokeguchi S, Tsujigiwa H, Asaumi J, Nagatsuka H, Fukui K, Kuroda M, Tanaka N, Matsubara N.
    • Journal Title

      Onclo. Rep. 17(6):

      Pages: 1461-1467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa2007

    • Author(s)
      Ishii T, Murakami J, Notohara K, Cullings HM, Sasamoto H, Kambara T, ShirakawaY, Naomoto Y, Ouchida M, Shimizu K, Tanaka N, Jass JR, Matsubara N.
    • Journal Title

      Gut 56

      Pages: 13-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Microsatellite instability and clinicopathological features in esophageal squamous cell cancer. (2007)2007

    • Author(s)
      Matsumoto, Y., Nagasaka, T., Kambara, T., Hoshizima N., Murakami, J., Sasamo to, H., Hosokawa, M., Naomoto, Y., Isozaki, H., Shimizu, K., Tanaka, N., Matsubara, N.
    • Journal Title

      Oncol. Rep. 18,

      Pages: 1123-1127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Heparanase promotes angiogenesis through Cox-2 and HIFlalpha2007

    • Author(s)
      Naomoto Y, Gunduz M, Takaoka M, Okawa T, Gunduz E, Nobuhisa T, Kobayashi M, Shirakawa Y, Yamatsuji T, Sonoda R, Matsuoka J, Tanaka N
    • Journal Title

      Med Hypotheses 68

      Pages: 162-165

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Translocation of heparanase into nucleus results in cell differentiation2007

    • Author(s)
      Nobuhisa T, Naomoto Y, Okawa T, Takaoka M, Gunduz M, Motoki T, Nagatsuka H, Tsujigiwa H, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Kurebayashi J, Nakajima M, Taniguchi S, Sagara J, Dong J, Tanaka N
    • Journal Title

      Cancer Sci 98

      Pages: 535-540

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa2007

    • Author(s)
      Ishii T, Murakami J, Notohara K, Cullings HM, Sasamoto H, Kambara T, Shirakawa Y, Naomoto Y, Ouchida M, Shimizu K, Tanaka N, Jass JR, Matsubara N.
    • Journal Title

      Gut 56

      Pages: 13-19

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] No duplicate KRAS mutation is identified on the same allele of gastric or colorectal cancer cells with multiple KRAS mutations.2007

    • Author(s)
      Kimura, K., Nagasaka, T., Sasamoto, H., Notohara, K., Takeda, M., Komnami, K., Ishii, T., Tanaka, N., Matsubara, N.
    • Journal Title

      J. Int. Med. Res. 35

      Pages: 450-457

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines2007

    • Author(s)
      Murakami J, Lee YJ, Kokeguchi S, Tsujigiwa H, Asaumi J, Nagatsuka H, Fukui K, Kuroda M, Tanaka N, Matsubara N.
    • Journal Title

      Oncol. Rep. 17(6)

      Pages: 1461-1467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] No duplicate KRAS mutation is identified on the same allele of gastric or colorectal cancer cells with multiple KRAS mutations2007

    • Author(s)
      Kimura, K., Nagasaka, T., Sasamoto, H., Notohara, K., Takeda, M., Komnami, K., Ishii, T., Tanaka, N., Matsubara, N.
    • Journal Title

      J. Int. Med. Res 35

      Pages: 450-457

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] No duplicate KRAS mutation is identified on the same allele of gastric or colorectal cancer cells with multiple KRAS mutations.2007

    • Author(s)
      Kimura, K., Nagasaka, T., Sasamoto, H., Notohara, K., Takeda, M., Komnami, K., Ishii, T., Tanaka, N., Matsubara, N.
    • Journal Title

      J. Int. Med. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Oesophageal squamous cell cancer may develop within a back ground of accumulating DNA methylation in normal and dys plastic mucosa.2007

    • Author(s)
      Ishii, T., Murakami, J., Notohara, K., Cullings, H.M., Sasamoto, H., Kambara, T., Shirakawa, Y., Naomoto, Y., Ouchida, M., Shimizu, K., Tanaka, N., Jass, J. R., Matsubara, N.
    • Journal Title

      Gut 56,

      Pages: 13-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Microsatellite instability and clinicopathological features in esophageal squamous cell cancer2007

    • Author(s)
      Matsumoto, Y., Nagasaka, T., Kambara, T., Hoshizima, N., Murakami, J., Sasamoto, H., Hosokawa, M., Naomoto, Y., Isozaki, H., Shimizu, K., Tanaka, N., Matsubara, N.
    • Journal Title

      Oncol. Rep. 18

      Pages: 1123-1127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] リンチ症候群のリクルートにおける病理組織・免疫染色・MSIテスト・somatic遺伝子検査の意義2007

    • Author(s)
      松原長秀、永坂岳司、田中紀章
    • Journal Title

      家族性腫瘍 7

      Pages: 11-14

    • NAID

      130007540975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Journal Article] Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa2007

    • Author(s)
      Ishii T, Murakami J, Notohara K, Cullings HM, Sasamoto H, Kambara T, Shirakawa Y, Naomoto Y, Ouchida M, Shimizu K, Tanaka N, Jass JR, Matsubara N
    • Journal Title

      GUT 56

      Pages: 13-19

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591402
  • [Journal Article] Pulmonary adenocarcinoma-targeted gene therapy by a cancer-and tissue-specific promoter system2007

    • Author(s)
      Fukazawa, T., Maeda, Y., Durbin, ML., Nakai, T., Matsuoka, J., Tanaka, H., Naomoto, Y., Tanaka, N
    • Journal Title

      Mol Cancer Then 6

      Pages: 244-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591548
  • [Journal Article] Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa.2007

    • Author(s)
      Ishii T., Murakami J., Notohara K., Cullings H.M., Sasamoto H., Kambara T., Shirakawa Y., Naomoto Y., Ouchida M., Shimizu K., Tanaka N., Jass J.R., Matsubara N.
    • Journal Title

      Gut 56

      Pages: 13-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591402
  • [Journal Article] Heparanase promotes angiogenesis through Cox-2 and HIF1alpha2007

    • Author(s)
      Naomoto Y, Gunduz M, Takaoka M, Okawa T, Gunduz E, Nobuhisa T, Kobayashi M, Shirakawa Y, Yamatsuji T, Sonoda R, Matsuoka J, Tanaka N
    • Journal Title

      Med Hypotheses 68

      Pages: 162-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] COX-2 induction by heparanase in the progression of breast cancer.2006

    • Author(s)
      Imada T, Matsuoka J, Nobuhisa T, Okawa T, Murata T, Tabuchi Y, Shirakawa Y, Ohra N, Gunduz M, Nagatsuka H, Umeoka T, Yamamoto Y, Nakajima M, Tanaka N, Naomoto Y.
    • Journal Title

      Int J Mol Med. Feb;17(2)

      Pages: 221-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.2006

    • Author(s)
      Ohtawa Y, Naomoto Y, Shirakawa Y, Takaoka M, Murata T, Sonoda R, Sakurama K, Yamatsuji T, Gunduz M, Tsujigiwa H, Nagatsuka H, Terada N, Itano S, Horiki S, Yanagihara K, Nakajima M, Tanaka N.
    • Journal Title

      Hum Pathol. 37

      Pages: 1145-1152

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach2006

    • Author(s)
      Ohtawa, Y., Naomoto, Y., Shirakawa, Y., Takaoka, M., Murata, T., Sonoda, R., Sakurama, K., Yamatsuji, T., Gunduz, M., Tsujigiwa, H., Nagatsuka, H., Terada, N., Itano, S., Horiki, S., Yanagihara, K., Nakajima, M., Tanaka, N
    • Journal Title

      Hum Pathol 37 (9)

      Pages: 1145-1152

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Journal Article] Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis.2006

    • Author(s)
      Ozaki K., Nagasaka T., Notohara K., Kambara T., Takeda M., Sasamoto H., Jass J.R., Tanaka N., Matsubara N.
    • Journal Title

      Int. J. Cancer 119 (11)

      Pages: 2513-2519

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591402
  • [Journal Article] Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis in oral cancer.2006

    • Author(s)
      Ozaki K, Nagasaka T, Notohara K, Kambara T, Takeda M, Sasamoto H, Jass JR, Tanaka N, Matsubara N
    • Journal Title

      International Journal of Cancer 119

      Pages: 2513-2519

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591402
  • [Journal Article] Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis.2006

    • Author(s)
      Ozaki, K., Nagasaka, T., Notohara, K., Kambara, T., Takeda, M., Sasamoto, H., Jass, J.R., Tanaka, N., Matsubara, N.
    • Journal Title

      Int. J. Cancer 119 (11)

      Pages: 2513-2519

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis.2006

    • Author(s)
      Ozaki, K., Nagasaka, T., Notohara, K., Kambara, T., Takeda, M., Sasamoto, H., Jass, J.R., Tanaka, N., Matsubara,N.
    • Journal Title

      Int.J.Cancer 119

      Pages: 2513-2519

    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.2005

    • Author(s)
      Noma K, Naomoto Y, Gunduz M, Matsuoka J, Yamatsuji T, Shirakawa Y, Nobuhisa T, Okawa T, Takaoka M, Tomono Y, Hiroyuki 0, Gunduz E, Tanaka N.
    • Journal Title

      Oncol Rep. Sep ; 14(3)

      Pages: 645-650

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Heparanase expression correlates with malignant potential in human colon cncer.2005

    • Author(s)
      Nobuhisa T, Naomoto Y, Ohkawa T, Takaoaka M, Ono R, Murata T, Gunduz M, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tsujigiwa H, Nagatsuka H, Nakajima M, Tanaka N.
    • Journal Title

      J Cancer Res Clin Oncol. Apr ; 131(4) Epub 2004 Dec 30

      Pages: 229-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Methylatio profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients.2005

    • Author(s)
      Naoki Kimura, Takeshi Nagasaka, Jun Murakami, Hiromi Sasamoto, Masahiro Murakami, Noriaki Tanaka, Nagahide Matsubara
    • Journal Title

      Nucleic Acids Res. 33(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] The role of heparanase in gastrointestinal cancer (Review).2005

    • Author(s)
      Naomoto Y, Takaoka M, Okawa T, Nobuhisa T, Gunduz M, Tanaka N.
    • Journal Title

      Oncol Rep. Jul ; 14(1) (Review)

      Pages: 3-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.2005

    • Author(s)
      Okawa T, Naomoto Y, Nobuhisa T, Takaoka M, Motoki T, Shirakawa Y, Yamatsuji T, Inoue H, Ouchida M, Gunduz M, Nakajima M, Tanaka N.
    • Journal Title

      Clin Cancer Res. Nov 15 ; 11(22)

      Pages: 7995-8005

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Methylatio profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients.2005

    • Author(s)
      Naoki Kimura, Takeshi Nagasaka, Jun Murakami, Hiromi Sasamoto, Masahiro Murakami, Noriaki Tanaka, Nagahide Matsubara
    • Journal Title

      Nucleic Acids Res. 33 (5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Emergence of nuclear heparanase induces differentiation of human mammary cancer cells.2005

    • Author(s)
      Nobuhisa T, Naomoto Y, Takaoka M, Tabuchi Y, Ookawa K, Kitamoto D, Gunduz E, Gunduz M, Nagatsuka H, Haisa M, Matsuoka J, Nakajima M, Tanaka N.
    • Journal Title

      Biochem Biophys Res Commun. May 27 ; 331(l)

      Pages: 175-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Role of 06-methylguanine-DNA methyltransferase and effect of 06-benzylguanine on the anti-tumor activity of cis-Diaminedichloroplatinum(II) in oral cancer cell lines.2005

    • Author(s)
      Yu Maki, Jun Murakami, Jun-ichi Asaumi, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka, Susumu Kokeguchi, Kazuhiro Fukui, Noriko Kawai, Yoshinobu Yanagil, Masahiro Kuroda, Noriaki Tanaka, Nagahide Matsubara, Kanji Kishil
    • Journal Title

      Oral Oncol. 41

      Pages: 984-993

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Journal Article] Allelic loss of a common microsatellite marker MYcL1: a useful prognostic factor of poor outcomes in colorectal cancer.2004

    • Author(s)
      Kambara, T., Sharp, GB., Nagasaka, T., Takeda, M., Sasamoto, H., Nakagawa, H., Isozaki, H., MacPhee, D.G., Jass, J.R., Tanaka, N., Matsubara, N.
    • Journal Title

      Clinical Cancer Res. 10

      Pages: 1758-1763

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Effects of demethylating agent 5-aza-2'-deoxycytidine and histone deacetylase inhibitor FR901228 on maspin gene expression in oral cancer cell lines.2004

    • Author(s)
      Murakami, J., Asaumi, J., Maki, Y., Tsujigiwa, H., Kuroda M., Nagai, N., Yanagi, Y., Inoue, T., Kawasaki, S., Tanaka, N., Matsubara.N., Kishi K.
    • Journal Title

      Oral Oncol. 40

      Pages: 597-603

    • NAID

      120002312161

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Methylation assay by nucleotide incorporation (MANIC): a novel, nonisotopic, quantitative assay for regional CpG methylation density.2004

    • Author(s)
      Takeshi Yamamoto, Takeshi Nagasaka, Kenji Notohara, Hiromi Sasamoto, Jun Murakami, Noriaki Tanaka, Nagahide Matsubara
    • Journal Title

      Bio Tchniques 36

      Pages: 846-855

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum.2004

    • Author(s)
      Takeshi Kambara, Lisa A.Simms, Vicki L.J.Whitehall, Kevin J.Spring, Coral V.A.Wynter, Michael D.Walsh, Melissa A.Barker, Sven Arnold, Andrina McGivern, Nagahide Matsubara, Noriaki Tanaka, Tetsuro Higuclu, Joanne Young, Jeremy R.Jass, Barbara A.Leggett
    • Journal Title

      Gut 53

      Pages: 1137-1144

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Allele-specific methylation analysis on upstream promoter region of H19 by methylation-specific PCR with confronting two-pair primers.2004

    • Author(s)
      Hiromi Sasamoto, Takeshi Nagasaka, Kenji Notohara, Kazuo Ozaki, Hiroshi Isozaki, Noriaki Tanaka, Nagahide Matsubara
    • Journal Title

      Int. J. Oncol. 25

      Pages: 1273-1278

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Influence of CpG island methylation status in 06-methylguanine-DNA methyltransferase expression of oral cancer cell lines.2004

    • Author(s)
      Murakami, J., Asaumi, J., Maki, Y., Tsujigiwa, H., Nagatsuka, H., Kokeguchi, S., Inoue, T., Kawasaki, S., Tanaka, N., MacPhee, D., Matsubara, N., Kishi, K.
    • Journal Title

      Oncol. Rep. 12

      Pages: 339-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Localization o heparanase in esophageal cancer cells : respective roles in prognosis and differentiation.2004

    • Author(s)
      OhkawaT, Naomoto Y, Takaoka M, Nobuhisa T, Noma K, Motoki T, Murata T, Uetsuka H, Kobayashi M, Shirakawa Y, Yamatsuji T, Matsubara N, Matsuoka J, Haisa M, Gunduz M, Tsujigiwa H, Nagatsuka H, Hosokawa M, Nakajima M, Tanaka N.
    • Journal Title

      Lab Invest. Oct ; 84(10)

      Pages: 1289-1304

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Effects of histone deacetylase inhibitor FR901228 on expression level of telomerase reverse transcriptase in oral cancer.2004

    • Author(s)
      Jun Murakami, Junichi Asaumi, Noriko Kawai, Hidetsugu Tsujigiwa, Yoshinobu Yanagi, Hitoshi Nagatsuka, Tetsuyoshi Inoue, Susumu Kokeguchi, Shoji Kawasaki, Masahiro Kuroda, Noriaki Tanaka, Nagahide Matsubara, Kanji Kishi
    • Journal Title

      Cancer Chemoth. Pharm.

    • NAID

      120002314067

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes show different patterns of DNA methylation.2004

    • Author(s)
      Takeshi Nagasaka, Hiromi Sasamoto, Kenji Notohara, Harry M.Cullings, Masanori Takeda, Keigo Kimura, Takeshi Kambara, Donald G.MacPhee, Joanne Young, Barbara A.Leggett, Jeremy R.Jass, Noriaki Tanaka, Nagahide Matsubara
    • Journal Title

      J. Clip. Oncol. 22(22)

      Pages: 4584-4594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Role of Inherited Defects of MYH in the Development of Sporadic Colorectal Cancer.2004

    • Author(s)
      Takeshi Kambara, Vicki L.J.Whitehall, Kevin J.Spring, Melissa A.Barker, Sven Arnold, Coral V.A.Wynter, Nagahide Matsubara, Noriaki Tanaka, Joanne P.Young, Barbara A.Leggett, Jeremy R.Jass
    • Journal Title

      Gene Chromosome Canc. 40

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Hypermethylation of 06-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases.2003

    • Author(s)
      Nagasaka, T., Sharp, GB., Notohara, K., Kambara, T., Sasamoto, H., Isozaki, H., MacPhee, D.G., Jass, J.R., Tanaka, N., Matsubara, N.
    • Journal Title

      Clinical Cancer Res. 9

      Pages: 5306-5312

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Journal Article] Heparanase expression correlates with invasion and poor prognosis in gastric cancers.2003

    • Author(s)
      Takaoaka M, Naomoto Y, Ohkawa T, Uetsuka H, Shirakawa Y, Uno F, Fujiwara T, Gunduz M, Nagatsuka H, Nakajima M, Tanaka N, Haisa M.
    • Journal Title

      Lab Invest. May ; 83(5)

      Pages: 613-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591319
  • [Journal Article] Allelic imbalance and microsatellite instability in plasma DNA released from polyclonal pancreatic adenocarcinoma.2002

    • Author(s)
      Moriyama, H., Matsubara, N., Kambara, T., Mori, M., Matsuoka, J., Yoshino, T., Takakura, N., Shimizu, K., Tanaka, N.
    • Journal Title

      Int. J. Oncol. 21

      Pages: 949-956

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14571198
  • [Patent] 特許 : 中皮腫特異的プロモータおよびその用途2008

    • Inventor(s)
      深澤拓也 松岡順治 田中紀章
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2008-104070
    • Filing Date
      2008-04-11
    • Data Source
      KAKENHI-PROJECT-19659353
  • [Patent] メチル化核酸又は非メチル化核酸を増幅する方法2007

    • Inventor(s)
      永坂岳司, 松原長秀, 田中紀章, 笹本博美
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2007-153086
    • Filing Date
      2007-06-08
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Patent] メチル化核酸又は非メチル化核酸を増幅する方法2007

    • Inventor(s)
      永坂岳司、松原長秀、田中紀章
    • Industrial Property Rights Holder
      岡山大学
    • Industrial Property Number
      2007-153086
    • Filing Date
      2007-06-08
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Patent] 糞便由来遺伝子の簡便増幅法2005

    • Inventor(s)
      田中紀章etc
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2005-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Patent] 消化器中の新生物の検出方法2005

    • Inventor(s)
      田中紀章etc
    • Industrial Property Rights Holder
      岡山大学etc
    • Filing Date
      2005-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Patent] 核酸修飾前の検体の前処理方法2005

    • Inventor(s)
      田中紀章etc
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2005-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390368
  • [Presentation] 便中DNAによる大腸癌発見法2008

    • Author(s)
      松原長秀、永坂岳司、田中紀章
    • Organizer
      第14回日本家族性腫瘍学会学術集会
    • Place of Presentation
      国立がんセンター東京(シンポジウム)
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] 大腸癌のepigenetic変異をコントロールするパスウェイとこれに基づく亜分類の診断・治療への応用2008

    • Author(s)
      松原長秀, 永坂岳司, 近藤喜太, 田中紀章
    • Organizer
      第63回日本大腸肛門病学会学術集会
    • Place of Presentation
      ホテル日航東京
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] Malignant Pleural Mesothelioma-Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy2008

    • Author(s)
      Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yutaka Maeda, Nakai Torn, Inoue Fumiyuki, Takahashi Masahiko, Mary Durbin, Noriaki Tanaka
    • Organizer
      日本癌学会第67回学術総会(English Workshop)
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19659353
  • [Presentation] 大腸癌のepigenetic変異をコントロールするパスウェイとこれに基づく亜分類の診断・治療への応用2008

    • Author(s)
      松原長秀、永坂岳司、近藤喜太、田中紀章
    • Organizer
      第63回日本大腸肛門病学会学術集会
    • Place of Presentation
      ホテル日航東京(パネルディスカッション)
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] 大腸癌鋸歯状病変よりの発癌機構と大腸癌に於ける位置づけ2008

    • Author(s)
      松原長秀,長尾厚樹,神原健,田中紀章
    • Organizer
      第19回日本消化器癌発生学会総会
    • Place of Presentation
      別府亀の井ホテル(ミニシンポジウム)
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] 大腸癌の前癌病変を含めた早期診断法の確立とtranslational researchへの問題点2008

    • Author(s)
      松原長秀、永坂岳司、内田卓之、笹本博美、戸田桂介、谷口信将、岡哲弘、田中紀章
    • Organizer
      第63回日本消化器外科学会総会
    • Place of Presentation
      札幌(ワークショップ)
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] Does laparoscopic surgery for colorectal cancer really contribute a lot to the post-operative patient's life2008

    • Author(s)
      Nagahide Matsubara, Yoshitaka Kondo, Naoya Kobayashi, Noriaki Tanaka
    • Organizer
      11^<th> World Congress of Endoscopic Surgery
    • Place of Presentation
      Yokohama, Japan(Workshop)
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] 大腸鋸歯状ポリープよりの発癌機構とその病変の大腸癌における位置づけ2007

    • Author(s)
      松原長秀、長尾厚樹、神原健、田中紀章
    • Organizer
      第88回日本消化器病学会中国支部例会
    • Place of Presentation
      岡山コンベンションセンター岡山
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] Multimodal treatment for rectal cancer. Symposium : Current topics of the surgical treatment for rectal cancer2007

    • Author(s)
      Nagahide Matsubara, Noriaki Tanaka
    • Organizer
      The International College of Surgeons. 17^<th> Joint Congress of Asia & Pacific Federations & 53^<rd> Annual Congress of the Japanese Section
    • Place of Presentation
      Westin Miyako Hotel Kyoto, Kyoto, Japan.
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] HNPCC screening上の課題 : シンポジウム[家族性腫瘍-基礎と臨床]2007

    • Author(s)
      松原長秀, 永坂岳司, 能登原憲司, 笹本博美, 田中紀章
    • Organizer
      第13回日本家族性腫瘍学会
    • Place of Presentation
      高知
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] リンチ症候群の大腸癌におけるepigeneticの関与2007

    • Author(s)
      松原長秀、永坂岳司、神原健、田中紀章
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19390351
  • [Presentation] Malignant pleural mesothelioma-targeted gene therapy2007

    • Author(s)
      Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yuataka Maeda, Mary L. Durbin, Noriaki Tanaka.
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591464
  • [Presentation] HUMAN NON-SMALL CELL LUNG CANCER TARGETED PROMOTER SYSTEM FOR GENE THERAPY2006

    • Author(s)
      Fukazawa, T., Matsuoka, J., Naomoto, Y., Nakai, T., Maeda, Y., Frances, M., Sladek, Laurie, B., Owen-Schaub, Jeffrey, Whitsett, Tanaka, N
    • Organizer
      65th Annual Meeting of Japanese Association for Cancer Research
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591548
  • 1.  MATSUBARA Nagahide (70314672)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 51 results
  • 2.  SHIMIZU Kenji (10037286)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 7 results
  • 3.  MATSUOKA Jyunji (30332795)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 18 results
  • 4.  NAOMOTO Yoshio (00237190)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 21 results
  • 5.  YAMATSUJI Tomoki (40379730)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 6.  ORITA Kunzo (20033053)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  NAKANISHI Toru (30243463)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  KOBAYASHI Naoya (10325102)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MOCHITATE Katsumi (20132863)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  FUKAZAWA Takuya (20379845)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 11.  TABATA Yashuiko (50211371)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  YOKOI Yokoishi (70135226)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  TANAKA Hirotosh (00171794)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 14.  KONDO Eisaku (30252951)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  NAGASAKA Takeshi (30452569)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 21 results
  • 16.  SAKAGAMI Kennichi (40124789)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  KOIDE Norio (20142333)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  ISOZAKI Hiroshi (50151436)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 19.  HAISA Minoru (70322229)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  KAMBARA Takeshi (60379724)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 21.  KAMIKAWA Yasuaki (00152851)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  大山 和美 (00253021)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 23.  NAKAJI Syuhei
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 24.  KATO Jun (90379743)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KATAYAMA Hiroshi (90161067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  ONO Toshiro (50185641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  MOMINOKI Katsumi (70304615)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  TSUTYA Tomoshi (30437884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KONDOU Yoshitaka (50534765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  SASAMOTO Hiromi (10452567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 31.  HAMAZAKI Keisuke (90172965)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  GOUCHI Akira (10186877)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  YAGI Takahito (00304353)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  MIYAZAKI Masahiro (90116509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  KOBAYASHI Eiji (00245044)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  KURABAYASHI Yuzuru (90033373)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  KOHARA Michinori (10250218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  HAYATSU Hikoya (10012593)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  MIMURA Hisashi (80116508)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  米澤 一仁 (70283900)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  吉野 健一 (90280792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  原 賢太 (70294254)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  滝川 正春 (20112063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  久保田 聡 (90221936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  AKASU Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  EJIRI Yoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  SADAMORI Hiroshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  JANE Lebkowsky
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  IRA J. Fox
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  繁光 薫
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  児玉 亮
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  樅木 勝巳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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