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NOZAWA Takashi  能澤 孝

ORCIDConnect your ORCID iD *help
Researcher Number 00180737
Affiliation (based on the past Project Information) *help 2014: 富山大学, その他の研究科, 准教授
2012 – 2014: 富山大学, 大学院医学薬学研究部(医学), 准教授
2009 – 2011: 富山大学, 大学院・医学薬学研究部(医学), 准教授
2008: 富山大学, 大学院・院医学薬学研究部(薬学), 准教授
2006 – 2008: University of Toyama, Faculty of Medicine, Associate Professor, 医学薬学研究部(医学), 准教授 … More
2006: 助教授
2006: UNIVERSITY OF TOYAMA, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 大学院医学薬学研究部, 助教授
2005: 富山大学, 医学部, 助教授
2004: Toyama Medical & Pharmaceutical University, Faculty of Medicine, Associate Professor, 医学部, 助教授
2002 – 2004: 富山医科薬科大学, 附属病院, 講師
1998 – 2001: 富山医科薬科大学, 医学部, 助手
1995: Toyama Med. & Pharm. Univ., assistant professor, 付属病院, 助手
1995: 富山医科薬科大学, 附属病院, 助手
1994: 富山医科薬科大学, 第2内科, 助手
1987: National Cardiovascular Center Research Institute, Director, 循環動態機能部, 研究員
1986: 国立循環器病センター研究所, 循環動態機能部・冠循環研究室, 室員 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine
Except Principal Investigator
Medical pharmacy / Circulatory organs internal medicine / Circulatory organs internal medicine / General physiology
Keywords
Principal Investigator
心肥大 / 心不全 / Cardiac metabolism / Glucose metabolism / Fatty acid metabolism / Sympathetic nerve / Hypertrophy / Heart failure / 心筋代謝 / グルコース代謝 … More / 脂肪酸代謝 / 交感神経 / insulin / hypertension / rat / hypertrophy / fatty acid / glucose / metabolism / heart failure / インスリン / 高血圧 / ラット / 脂肪酸 / グルコース / 代謝 … More
Except Principal Investigator
心不全 / 交感神経 / heart failure / 腎臓 / 高血圧 / 心臓 / sympathetic nerve / Kidney / Sympathetic nerve / beta-receptor / β受容体 / 採血デザイン / カルベジロール / 臨床薬物動態試験 / oxygen consumplion / mechanical energy / syslolic pressure-volume area / energy efficiency / myocardium / heart / ATP / 圧容積図 / 効率 / エナジェティクス / 心筋 / 収縮機構 / 酸素消費量 / 機械的エネルギー / 収縮期圧容積面積 / 心臓・心筋・エネルギー効率 / Norepinephrine / Hypertension / Heart Failure / pharmacokinetics / β-blocker / CYP2D6 / メトプロロール / ビソプロロール / 人種差 / 薬物体内動態 / β遮断薬 / norepinephrine / microdialysis / kidney / hypertension / 食塩感受性 / 心肥大 / マイクロダイリシス / ノルエピネフリン / マイクロダイアリシス / catecholamine / nearve growth factor / myocardial ischemia / カテコラミン / 神経成長因子 / 心筋虚血 / Rat / Heart failure / Myocardial infarction / ラット / 心筋梗塞 / Cardiac Sympathetic Nerve Function / Hypertensive Heart disease / Dahl Rat / Herat Failure / オートラジオグラフィ / 心臓交感神経 / 心臓交感神経機能 / ダールラット / トランスポーター / 消化管吸収機構 / 腎排泄性薬剤 / ミゾリビン / バイオアベイラビリオティ / ピーク・トラフ / 個別投与設計 / 臨床試験 / 薬物動態 / 経口クリアランス / 2点採血デザイン / 薬物動態学 Less
  • Research Projects

    (12 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (18 People)
  •  Variability of bioavailability and intestinal absorption mechanism of mizoribine and bisoprolol

    • Principal Investigator
      HASHIMOTO Yukiya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Clinical pharmacokinetic trials using limited sampling design and robust data analysis

    • Principal Investigator
      HASHIMOTO Yukiya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Design and Data Analysis for clinical pharmacokinetic trials to Evaluate Mechanisms for the Pharmacokinetic Variability

    • Principal Investigator
      HASHIMOTO Yukiya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Mechanism of the pharmacokinetic variability and race difference of β-blockers

    • Principal Investigator
      HASHIMOTO Yukiya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      University of Toyama
  •  Levels of interstitial norepinephrine in the heart and kidney during the development of hypertensive heart failure

    • Principal Investigator
      INOUE Hiroshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Toyama
  •  Sympathoexcitation in heart failure-Norepinephrine kinetics in sympathetic nerve terminals.

    • Principal Investigator
      INOUE Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Sympathetic nerve activity and cardiac energy metabolism during the development of hypertensive heart failurePrincipal Investigator

    • Principal Investigator
      NOZAWA Takashi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Effect of nerve growth factor on sympathetic neuronal function in heart failure after myocardial infarction

    • Principal Investigator
      INOUE Hiroshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Cardiac energy metabolism during development of hypertensive heart failurePrincipal Investigator

    • Principal Investigator
      NOZAWA Takashi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Effects of Long-Term Renal Denervation on Left Ventricular Remodeling Afetr Myocardial Infarction in Rats.

    • Principal Investigator
      INOUE Hiroshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  An evaluation of sympathetic nerve function in fuiling hearts

    • Principal Investigator
      INOUE Hiroshi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Faclors ioncreasing the energy conversion efficiency of myocardial contractile machinery

    • Principal Investigator
      SUGA Hiroyuki
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General physiology
    • Research Institution
      National Cardiovascular Cenler Research lnstitute,

All 2008 2007 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Pharmacokinetics of R-and S-carvedilol in routinely treated Japanese patients with heart failure2008

    • Author(s)
      Horiuchi I., Nozawa T, Fujii N., Inoue H., Honda M, Shimizu T, Taguchi M, and Hashimoto Y.
    • Journal Title

      Biol. Pharm. Bull 23

      Pages: 976-980

    • NAID

      110006663963

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590139
  • [Journal Article] UGT2B7*3 did not affect the pharmacokinetics of R-and S carvedilol in healthy Japanese2007

    • Author(s)
      Honda M, oyoda W, Shimizu T, Horiuchi I., Kayano Y, Taguchi M., Nozawa T, Inoue H, and Hashimoto Y.
    • Journal Title

      Drug Metab. Pharmacokinet 22

      Pages: 382-386

    • NAID

      10019806805

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590139
  • [Journal Article] Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment : a comparison with bisoprolol2005

    • Author(s)
      Nozawa, Takashi
    • Journal Title

      J.Cardiovasc.Pharmacol. 46・5

      Pages: 713-720

    • Data Source
      KAKENHI-PROJECT-17590117
  • [Journal Article] Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment : a comparison with bisoprolol.2005

    • Author(s)
      Nozawa, Takashi
    • Journal Title

      J. Cardiovasc. Pharmacol. 46・5

      Pages: 713-720

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590117
  • [Journal Article] Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment : a comparison with bisoprolol.2005

    • Author(s)
      Nozawa, Takashi
    • Journal Title

      J.Cardiovasc.Pharmacol. 46(5)

      Pages: 713-720

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590117
  • [Journal Article] Ischemia-induced norepinephrine release, but not norepinephrine-derived free-radicals, contributes to myocardial ischemia-reperfusion injury.2005

    • Author(s)
      M Nonomura, T Nozawa, H Inoue, et al.
    • Journal Title

      Circ J 69(in press)

    • NAID

      110002696145

    • Data Source
      KAKENHI-PROJECT-15590730
  • [Journal Article] Discrepant recovery course of sympathetic neuronal function and β-adrenoceptors in rat hearts after reperfusion following transient Ischemia.2004

    • Author(s)
      B Kato, T Nozawa, H Inoue, et al.
    • Journal Title

      J Nucl Med 45

      Pages: 1074-1080

    • Data Source
      KAKENHI-PROJECT-15590730
  • [Journal Article] Discrepant recovery course of sympathetic neuronal function and β-adrenoceptors in rat hearts after reperfusion following transient ischemia.2004

    • Author(s)
      B Kato, T Nozawa, H Inoue, et al.
    • Journal Title

      J Nucl Med 45

      Pages: 1074-1080

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590730
  • [Journal Article] Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure.2004

    • Author(s)
      N Fujii, T Nozawa, H Inoue, et al.
    • Journal Title

      Am J Physiol 287

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590730
  • [Journal Article] Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction.2003

    • Author(s)
      A.Igawa, T Nozawa, H Inoue, et al.
    • Journal Title

      J Am Coll Cardiol 42

      Pages: 541-548

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590730
  • [Journal Article] Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction.2003

    • Author(s)
      A Igawa, T Nozawa, H Inoue, et al.
    • Journal Title

      J Am Coll Cardiol 42

      Pages: 541-548

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590730
  • [Presentation] 心不全時におけるカルベジロール体内動態の変動性評価2007

    • Author(s)
      堀内威佐男, 本多睦子, 清水貴子, 萱野勇一郎, 田口雅登, 能澤孝, 井上博, 橋本征也
    • Organizer
      日本薬学会北陸支部第117回例会
    • Place of Presentation
      金沢
    • Year and Date
      2007-11-11
    • Data Source
      KAKENHI-PROJECT-19590139
  • [Presentation] 日本人健常者のカルベジロール体内動態に及ぼすUGT2B7*3の影響2007

    • Author(s)
      田口雅登, 本多睦子, 豊田若子, 堀内威佐男, 清水貴子, 萱野勇一郎, 橋本征也, 能澤孝, 井上博
    • Organizer
      日本医療薬学会第17年会
    • Place of Presentation
      前橋
    • Data Source
      KAKENHI-PROJECT-19590139
  • 1.  INOUE Hiroshi (60151619)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 6 results
  • 2.  HASHIMOTO Yukiya (90228429)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 3.  TAGUCHI Masato (20324056)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 4.  ISHIDA Kazuya (90550509)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  ASANOI Hidetsugu (00150128)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  FUJIKI Akira (90181338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YUICHIRO Kayano (80452093)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  ICHIDA Fukiko (30223100)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TAKASHIMA Syuutaro (50146586)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  HIRAI Tadakazu (10303215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TOMODA Fumihiro (90251884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HONDA Mutsuko (60422630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SUGA Hiroyuki (90014117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TANAKA Nobuaki (50197456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  FUTAKI Shiho (60190112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YASUMURA Yoshio (30183669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  合葉 哲也 (00231754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  後藤 葉一 (40142179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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