Shirafuji Naoki 白藤尚毅

… Alternative Names

白藤尚毅シラフジナオキ

SHIRAFUJI Naoki 白藤尚毅

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Researcher Number	00206301
Other IDs
Affiliation (Current)	2025: 帝京大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2017: 帝京大学, 医学部, 教授 2001 – 2002: 帝京大学, 医学部内科, 助教授 2000 – 2002: 帝京大学, 医学部, 助教授 1998 – 1999: 東京大学, 医科学研究所, 講師 1988 – 1989: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Tumor therapeutics / Hematology / Regenerative medicine Except Principal Investigator Hematology
Keywords	Principal Investigator 抗腫瘍効果 / 造血幹細胞 / CD34 / 骨髄芽球 / 好中球 / 遺伝子運搬 / CD19 / CLL-1 / G-CSF / PBSCT … More / CAR-T / 遺伝子導入 / CD47 / liposome / Adenovirus / gene therapy / cytochrome C oxidase / antisense RNA / mitochondria / 白血病 / リボゾーム / アデノウィルス / 遺伝子治療 / アンチセンスRNA / チトクロームCオキシダーゼ / ミトコンドリア / VEGF-C / interleukin 1 beta / 脱分化 / ヒト皮膚線維芽細胞 / electrical stimulation / poly I:C / VEGF-A / Interleukin-1 / hematopoietic stem cell / human dermal fibroblast / HDF / myofibroblast / HSC / IL-1 beta / CD45 / CD31 / CD41 / 血管内皮前駆細胞 / インターロイキン１ベータ / 皮膚線維芽細胞 … More Except Principal Investigator SNPs / Balb / WEHI / 白血病 / GM-CSF / 02Receptor for granulocyte colony-stimulating factor, / Intracellular signal transduction / Acute Myelogenous leukemia, / Granulocyte colony-stimulating factor, / アルカリフォスファターゼ / 受容体 / 成熟停止 / コロニー刺激因子 / 顆粒球 / アルカリフォスファタ-ゼ / ミエロペルオキシタ-ゼ / 細胞内情報伝達 / 細胞内シグナル伝達系 / 骨髄性白血病 / 顆粒球コロニ-刺激因子受容体 / 顆粒球コロニ-刺激因子 / prognosis / incidence / Chronic myelogenous leukemia / genome / インターフェロン / 予後 / 発病 / 慢性骨髄性白血病 / ゲノム / c mouse / 3B Cells / SAGE method / Tumor vaccination / Leukemia / CD34 / Immunogene therapy / c / BALB / MIF / IL-11 / 造腫瘍抑制効果 / MFGレトロウイルスベクター / WEHI3B細胞 / cマウス / 3B細胞 / SAGE法 / 腫瘍ワクチン / 免疫遺伝子治療 / 顆粒球マクロファージコロニー刺激因子 / ワクチン接種 / ポリオウイルス / GVHD / 特異抗体 / 骨髄移植 Less

gene introduction using myeloid lineage cellsPrincipal Investigator
- Principal Investigator
  
  Shirafuji Naoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Teikyo University
IL-1 beta induced vascular endothelial markers in HFDPrincipal Investigator
- Principal Investigator
  
  Shirafuji Naoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Regenerative medicine
- Research Institution
  Teikyo University
Gene study related to chronic myelogenous leukemia
- Principal Investigator
  
  SATO Noriharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Feasibility of MARCO(Mitochondrial antisense RNA for cytochrome C Oxidase) for the treatment of leukerniazPrincipal Investigator
- Principal Investigator
  
  SHIRATUJI Naoki
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Teikyo University School of Medicine
  The University of Tokyo
Development of new immunogene therapy for refractory leukemia and lymphoma
- Principal Investigator
  
  TANI Kenzaburo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
骨髄移植後の抗ウイルス抗体産生に関する基礎的研究
- Principal Investigator
  
  幸道秀樹
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Molecular Analysis of Acute Myelogenous Leukemia Cells Using G-CSF
- Principal Investigator
  
  ASANO Shigetaka
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The Institute of Medical Science, The University of Tokyo (IMSUT)

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Direct Factor X sequestration by systemic amyloid lightchain amyloidosis2018
- Author(s)
  Haruko Tashiro, Ryosuke Shirasaki, Masato Watanabe, Kazuo Kawasugi, Yoshihisa Takahashi, Naoki Shirafuji
- Journal Title
  
  Clinical Case Reports
  
  Volume: 6(3): Issue: 3 Pages: 513-515
- DOI
  10.1002/ccr3.1398
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Journal Article] Aggressive NK Cell Leukemia with Hemophagocytic Lymphohistiocytosis: A Case Report2017
- Author(s)
  Kimiko Nogi, Haruko Tashiro, Kazuo Kawasugi, Mayumi Matsuzawa, Takeshi Osawa, Ryohei Toyooka, Taiji Furukawa, Naoki Shirafuji
- Journal Title
  
  J Clin Lab Med
  
  Volume: 2.2 Issue: 2 Pages: 1-4
- DOI
  10.16966/2572-9578.116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Journal Article] Elevated level of serum antinuclear antibody and hemophagocytic syndrome in Asian-variant intravascular large B-cell lymphoma: a case report with its diagnostic pitfalls.2016
- Author(s)
  Kikuchi Y, Ota Y, Matsuo T, ShirafujiN, Kondo F, Uozaki H
- Journal Title
  
  Int J Clin Exp Pathol.
  
  Volume: 9 Pages: 7739-7743
- Data Source
  KAKENHI-PROJECT-16K14634
[Journal Article] Hyperuricemia in hematologic malignancies is caused by an insufficient urinary excretion.2014
- Author(s)
  Yoko Oka, Haruko Tashiro, Ryosuke Sirasaki, Tadashi Yamamoto, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji, Shin Fujimori.
- Journal Title
  
  Nucleosides, Nucleotides, andNucleic Acids
  
  Volume: 33 Pages: 434-438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] IL-1-βと電気刺激による成人ヒト皮膚線維芽細胞のhemogenic endotheliumへの変化に関する研究2018
- Author(s)
  白藤尚毅,松尾琢二,住吉立,田代晴子
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Perkinson’s disease (PD) developed after Bortezomib (Bor)-containing chemotherapy for Mantle cell lymphoma (MCL)2017
- Author(s)
  Yoko Miura, Takuji Matsuo, Ritsu Sumiyoshi, Tadashi Yamamoto, Haruko Tashiro, Kennsuke Matsumoto, Jun Ooi, Naoki Shirafuji.
- Organizer
  78回日本血液学会総会（10月、横浜）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] 好中球増多を伴った多発性骨髄腫の１例。2017
- Author(s)
  芳賀、幸、松本謙介、住吉　立，松尾　琢二，山本　義，白崎良輔、田代晴子、大井　淳，白藤尚毅、滝川　一。
- Organizer
  第633回日本内科学会関東地方会 (6月、東京)
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] FLT3-ITD mutation in MDS patients is associated with early transformation to AML2017
- Author(s)
  Ritsu Sumiyoshi, Haruko Tashiro, Takuji Matsuo, Tadashi Yamamoto, Yoko Oka-Miura, Kensuke Matsumoto, Jun Ooi, Naoki Shirafuji.
- Organizer
  59th ASH meeting (December, Atlanta, Georgia, USA,)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] FLT3-ITD mutation in MDS onset is associated with early transformation to AML2017
- Author(s)
  Ritsu Sumiyoshi, Tadashi Yamamoto, Takuji Matsuo, Yoko Oka-Miura, Haruko Tashiro, Kensuke Matsumoto, Jun Ooi, Naoki Shirafuji.
- Organizer
  78回日本血液学会総会（10月、横浜）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] ABO不適合臍帯血移植後のドナー由来赤血球抗原量の解析2017
- Author(s)
  蟹井はるか、藤原孝記、前島理恵子、冨山秀和、灰野夏澄、金子　強、永友ひとみ、笠井英利、難波宏美、大曽根和子、松本謙介、白藤尚毅。
- Organizer
  第65回日本輸血・細胞治療学会（6月、千葉）
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] 全身性アミロイドーシスによる高度の第X因子欠乏を来したB細胞性リンパ増殖性疾患2017
- Author(s)
  田代晴子、住吉　立，松尾　琢二，山本　義，松本謙介、大井　淳，秋山　暢，川杉　和夫，白藤尚毅。
- Organizer
  第7回日本血液学会関東甲信越地方会（7月、松本）
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Low high-density lipoprotein cholesterol (HDL) is a significant poor prognostic factor in malignant lymphoma2017
- Author(s)
  Takuji Matsuo, Haruko Tashiro, Ritsu Sumiyoshi, Tadashi Yamamoto, Yoko Oka-Miura, Kensuke Matsumoto, Jun Ooi, Naoki Shirafuji
- Organizer
  59th ASH meeting (December, Atlanta, Georgia, USA,)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] 赤血球抗原情報検索システムの有用性と問題点について2017
- Author(s)
  灰野夏澄、前島理恵子、藤原孝記、冨山秀和、金子　強、永友ひとみ、蟹井はるか、笠井英利、難波宏美、大曽根和子、松本謙介、白藤尚毅。
- Organizer
  第65回日本輸血・細胞治療学会（6月、千葉）
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Primary Adrenal Lymphoma with Adrenal Insufficiency: Report of Three Cases and Review of Literature2017
- Author(s)
  Masumi Ogawa, Naoki Edo, Takuji Matsuo, Tadashi Yamamoto, Satoshi Takahashi, Yamato Mashimo, Koji Morita, Yuko Sasajima, Hiroshi Uozaki, Fukuo Kondo, Yasunori Ota, Naoki Shirafuji, Hiroko Okinaga, Kazuhisa Tsukamoto, Toshio Ishikawa.
- Organizer
  ENDO 2017 (April, Orlando, Florida USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Low HDL is a significant poor prognostic factor in malignant lymphoma (ML)2017
- Author(s)
  Takuji Matsuo, Ritsu Sumiyoshi, Tadashi Yamamoto, Haruko Tashiro, Kensuke Matsumoto, Jun Ooi, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  78回日本血液学会総会（10月、横浜）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Outcome of salvage chemotherapy against relapsed or refractory advanced non-Hodgkin’s lymphoma cases2016
- Author(s)
  Takuji Matsuo, Ritsu Sumiyoshi, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  77th JSH
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Vascular endothelial cell-relating molecules expressed in an adult human dermal fibroblast when cultured with interleukin-1-beta2016
- Author(s)
  Rhitsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  EHA
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Biological effect of IL-1-beta to HDF for a long-term culture2016
- Author(s)
  Rhitsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  21th European Hematology Association
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] Biological effect of IL-1-beta to HDF for a long-term culture2016
- Author(s)
  Ritsu Sumiyoshi, Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka-Miura, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  77th JSH
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K14634
[Presentation] Hemogenic endothelium-like changes were observed in an adult human dermal fibroblast with an electrical stimulation.2015
- Author(s)
  Ritsu Sumiyoshi, Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka-Miura, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji.
- Organizer
  第76回　日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] Hemogenic endothelium-like changes were observed in an adult human dermal fibroblast with poly (I:C) culture and an electrical stimulation2015
- Author(s)
  Takuji Matsuo, Rhitsu Sumiyoshi, Ryosuke Shirasaki, Yoko Oka-Miura, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Naoki Shirafuji.
- Organizer
  44th International Society for Experimental Hematology Annual Meeting
- Place of Presentation
  Kyoto Japan
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] Adult human dermal fibroblasts was induced to express GATA-2 when they were cultured with interleukin 1-beta, erythropietin, and anti-human vascular endothelial growth factor-C antibody
- Author(s)
  Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka, Kennsuke Matsumoto, Jun Ooi, and Naoki Shirafuji.
- Organizer
  19th European Hematology Association annual meeting
- Place of Presentation
  Itaria, Milan
- Year and Date
  2014-06-12 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] Hemogenic endothelium-like changes were derived to an adult human dermal fibroblast by electrical stimulation
- Author(s)
  Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka, Tadashi Yamamoto, Kennsuke Matsumoto, Jun Ooi, Naoki Shirafuji.
- Organizer
  56th American Society of Hematology annual meeting
- Place of Presentation
  USA, San Francisco
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25505005
[Presentation] Stratification of diffuse large B-cell lymphoma cases according to NCCN-IPI: single institutional analysis
- Author(s)
  Takuji Matsuo, Ryosuke Shirasaki, Yoko Oka, Haruko Tashiro, Tadashi Yamamoto, Kennsuke Matsumoto, Nobu Akiyama, Kazuo Kawasugi, Jun Ooi, Naoki Shirafuji.
- Organizer
  第75回日本血液学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25505005

1. ASANO Shigetaka (50134614)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. SATO Noriharu (90162461)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TANI Kenzaburo (00183864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TOJO Arinobu (00211681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 幸道秀樹 (80161876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MATSUDA Satoru (50242110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OZAWA Keiya (30137707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 岡陽子 (00599673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 白崎良輔 (40569133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 家城隆次 (60168086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 片桐拓也 (70126100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大井淳 (20302606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 井関徹 (10232365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山本雅 (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 渋谷正史 (10107427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. GOTO Moritaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Tashiro Haruko

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

Shirafuji Naoki 白藤 尚毅

白藤 尚毅 シラフジ ナオキ

SHIRAFUJI Naoki 白藤 尚毅

Research Projects

Research Products

Co-Researchers

gene introduction using myeloid lineage cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-1 beta induced vascular endothelial markers in HFDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene study related to chronic myelogenous leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Feasibility of MARCO(Mitochondrial antisense RNA for cytochrome C Oxidase) for the treatment of leukerniazPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new immunogene therapy for refractory leukemia and lymphoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨髄移植後の抗ウイルス抗体産生に関する基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Analysis of Acute Myelogenous Leukemia Cells Using G-CSF

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Direct Factor X sequestration by systemic amyloid lightchain amyloidosis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aggressive NK Cell Leukemia with Hemophagocytic Lymphohistiocytosis: A Case Report2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elevated level of serum antinuclear antibody and hemophagocytic syndrome in Asian-variant intravascular large B-cell lymphoma: a case report with its diagnostic pitfalls.2016

Author(s)

Journal Title

Data Source

[Journal Article] Hyperuricemia in hematologic malignancies is caused by an insufficient urinary excretion.2014

Author(s)

Journal Title

Data Source

[Presentation] IL-1-βと電気刺激による成人ヒト皮膚線維芽細胞のhemogenic endotheliumへの変化に関する研究2018

Author(s)

Organizer

Data Source

[Presentation] Perkinson’s disease (PD) developed after Bortezomib (Bor)-containing chemotherapy for Mantle cell lymphoma (MCL)2017

Author(s)

Organizer

Data Source

[Presentation] 好中球増多を伴った多発性骨髄腫の１例。2017

Author(s)

Organizer

Data Source

[Presentation] FLT3-ITD mutation in MDS patients is associated with early transformation to AML2017

Author(s)

Shirafuji Naoki 白藤尚毅

白藤尚毅シラフジナオキ

SHIRAFUJI Naoki 白藤尚毅