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Miwa Hiroshi  三輪 啓志

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MIWA Hiroshi  三輪 啓志

MIWA Hroshi  三輪 啓志

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Researcher Number 00209967
Other IDs
Affiliation (Current) 2025: 三重大学, 医学系研究科, 産学官連携講座准教授
Affiliation (based on the past Project Information) *help 2020 – 2025: 三重大学, 医学系研究科, 産学官連携講座准教授
2019: 三重大学, 医学系研究科, 特任准教授(研究担当)
2011: 愛知医科大学, 医学部, 教授
2009 – 2010: 愛知医科大学, 医学部, 准教授
1993 – 1996: Mie University Hospital, Assistant, 医学部・附属病院, 助手 … More
1995: Mie University, Mie University Hospital, Assistant, 医学部附属病院, 助手
1994: 医学部。附属病院, 助手
1991 – 1992: Mie University University Hospital, Assistant, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Hematology / General fisheries / Hematology
Keywords
Principal Investigator
エネルギー代謝 / CAR-T細胞 / 解糖阻害薬 / 代謝改変 / CAR-T細胞療法 / 表現型 / MDR1 / WT-1 / 血液幹細胞 / 白血病 … More
Except Principal Investigator
… More 幹細胞様メモリーT細胞 / γδ-T細胞 / 急性骨髄性白血病(AML) / 急性リンパ性白血病(ALL) / 免疫遺伝子型 / リンパ系腫瘍 / 免疫表現型 / 悪性リンパ腫 / CAR / off-the-shelf / 細胞免疫療法 / 固形がん / persistence / CAR-T細胞 / 同種γδ-T細胞 / キメラ抗原受容体 / MAGE-A4 / TCR様抗体 / 遺伝子改変 / ミトコンドリア機能 / αβ-TCR / γδT細胞 / AML classification / stem cell / MDR1 gene / cytokine receptor / chromosome / Phenotype / ALL / AML / 造血因子受容体 / 白血病分類 / 幹細胞 / 多剤耐性遺伝子 / 増殖因子受容体 / 染色体異常 / 表現型 / PRAD-1 gone expression / CD5 positive B-cell lymphona / CD7 positive acute leukemia / c-kit gene expression / IL-7 receptor gene expression / Immunogenotyfe / Immunophenotype / Lymphoid malignanoy / CD5発現 / c-kit遺伝子発現 / B細胞リンパ腫 / CD7陽性急性骨髄性白血病(AML) / PRAD-1遺伝子発現 / CD5陽性B細胞リンパ腫 / CD7陽性急性白血病 / c-hit遺伝子発現 / IL-7受容体遺伝子発現 / indolent type / Cmu gene deletion / mature B-cell malignancy / AUL (acute unclassified leukemia) / dual genotype / immunogenotype / immunophenotype / lymphoid malignancy / 予後 / 急性分類不能白血病(AUL) / B前駆細胞性腫瘍 / 骨髄球系抗原 / 二重遺伝子型 / indolent型病型 / 病態 / Cμ遺伝子欠落 / CD11c / CD5 / B細胞分化 / 成熟B細胞腫瘍 / 薬剤耐性 / ストローマ / stage / 大腸癌 / 食道癌 / 白血病 / TM / TFPI / TF / 造血因子 / 細胞周期 / 造血幹細胞 Less
  • Research Projects

    (14 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (14 People)
  •  代謝改変を利用したCAR-T細胞由来エクソソーム治療開発に向けてPrincipal Investigator

    • Principal Investigator
      三輪 啓志
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  Analysis of tumor supressing function by Hybrid-TCR system

    • Principal Investigator
      赤堀 泰
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  Aim to eliminate a bottleneck in the practical realization of anticancer immunotherapy with gene-modified allogeneic gammadelta T cells.

    • Principal Investigator
      藤原 弘
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  幹細胞様メモリーT細胞分画に優れるγδ-T細胞の誘導法の検討

    • Principal Investigator
      石原 幹也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  代謝改変によるCAR-T細胞療法の有効性向上の試みPrincipal Investigator

    • Principal Investigator
      三輪 啓志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  Pursuit of multifunctional gene-modified gamma-delta T cells focusing on energy metabolism

    • Principal Investigator
      Ishihara Mikiya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  Next generation CAR-T cell therapy considering metabolism of tumor cells and CAR-T cellsPrincipal Investigator

    • Principal Investigator
      MIWA Hiroshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Mie University
  •  The Role of Reactive Oxygen Species In Apoptosis Induction of Mantle Cell Lymphoma(MCL); Inhibition of NADPH Oxidase 2 Induces Apoptosis In MCL

    • Principal Investigator
      MIURA Yuji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Aichi Medical University
  •  癌転移・浸潤における外因系止血機構、特に組織因子とそのインヒビターの役割

    • Principal Investigator
      和田 英夫
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Mie University
  •  造血幹細胞の細胞周期に関する研究

    • Principal Investigator
      KATAYAMA Naoyuki
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  Study for reconstitution of the AML classification on the basis of the biological characteristics.

    • Principal Investigator
      KITA Kenkichi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  がん抑制遺伝子WT-1の造血における役割と白血病発症への関与Principal Investigator

    • Principal Investigator
      三輪 啓志
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  Study on clinicoparhological characteristics of lymphoid malignaxcy based upon immunological and molecular biological analysis.

    • Principal Investigator
      SHIRAKAWA Shigeru
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General fisheries
    • Research Institution
      Mie University
  •  Pathological analyses of lymphoid malignancies based on immunological and molecular biological characteristics.

    • Principal Investigator
      SHIRAKAWA Shigeru
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Mie University

All 2023 2022 2021 2020 2019 2010

All Journal Article Presentation

  • [Journal Article] αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence2023

    • Author(s)
      Ishihara Mikiya、Miwa Hiroshi、Fujiwara Hiroshi、Akahori Yasushi、Kato Takuma、Tanaka Yoshimasa、Tawara Isao、Shiku Hiroshi
    • Journal Title

      iScience

      Volume: 26 Issue: 10 Pages: 107802-107802

    • DOI

      10.1016/j.isci.2023.107802

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07228, KAKENHI-PROJECT-23K06714, KAKENHI-PROJECT-23K06740, KAKENHI-PROJECT-23K27455
  • [Journal Article] The Role of Reactive Oxygen Species In Apoptosis Induction of Mantle Cell Lymphoma(MCL)2010

    • Author(s)
      Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, and Masanori Daibata
    • Journal Title

      Inhibition of NADPH Oxidase 2 Induces Apoptosis In MCL. Blood

      Volume: 116 Pages: 3616-3616

    • Data Source
      KAKENHI-PROJECT-21591226
  • [Presentation] αβ-TCR transduction into γδ-T cells enhances mitochondrial function2023

    • Author(s)
      Mikiya Ishihara, Hiroshi Miwa, Hiroshi Fujiwara, Yasushi Akahori, Takuma Kato, Yoshimasa Tanaka, Isao Tawara and Hiroshi Shiku
    • Organizer
      The 10th International γδ T cell conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06740
  • [Presentation] NY-ESO-1特異的αβTCR遺伝子導入γδT細胞の機能とエネルギー代謝特性2022

    • Author(s)
      石原 幹也、三輪 啓志、藤原 弘、赤堀 泰、加藤 琢磨、田中 義正、俵 功、珠玖 洋
    • Organizer
      第6回 日本サルコーマ治療研究学会
    • Data Source
      KAKENHI-PROJECT-20K07656
  • [Presentation] Energy metabolism spread to non-glycolysis in αβ-TCR transduced γδ-T cells2022

    • Author(s)
      石原 幹也、三輪 啓志、藤原 弘、赤堀 泰、加藤 琢磨、田中 義正、俵 功、珠玖 洋
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07656
  • [Presentation] NY-ESO-1特異的αβTCR遺伝子導入γδT細胞のエネルギー代謝2022

    • Author(s)
      石原 幹也、三輪 啓志、藤原 弘、赤堀 泰、加藤 琢磨、田中 義正、俵 功、珠玖 洋
    • Organizer
      第26回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-20K07656
  • [Presentation] NY-ESO-1特異的αβTCR導入Vδ2+細胞の機能と代謝2021

    • Author(s)
      石原 幹也、 三輪 啓志、 赤堀 泰、 藤原 弘、 加藤 琢磨、 田中 義正、 俵 功、 珠玖 洋
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] Function and metabolism of NY-ESO-1-specific γδ TCR transduced Vδ2+ cells2021

    • Author(s)
      Mikiya Ishihara,Hiroshi Miwa, Yasushi Akahori, Hiroshi Fujiwara, Takuma Kato, Yoshimasa Tanaka, Isao Tawara and Hiroshi Shiku
    • Organizer
      第80回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-20K07656
  • [Presentation] Accession of GITRL improves anti-leukemia functionality of CD19 CAR-T cells via metabolic behavior2020

    • Author(s)
      三輪啓志、藤原 弘、赤堀 泰、王 立楠、奥村悟志、田中義正、加藤琢磨、宮原慶裕、珠玖洋
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] グルココルチコイド誘導腫瘍壊死因子受容体リガンド(GITRL)付加による CD19 CAR-T細胞療法有効性向上の試み2020

    • Author(s)
      三輪啓志、藤原 弘、赤堀 泰、王 立楠、奥村悟志、田中義正、加藤琢磨、宮原慶裕、珠玖洋
    • Organizer
      第24回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] 有効性向上を目指したB細胞腫瘍に対する新たなCD19 CAR-T細胞療法の開発研究2019

    • Author(s)
      三輪啓志、藤原 弘、赤堀 泰、王 立楠、奥村悟司、田中義正、加藤琢磨、宮原慶裕、珠玖 洋
    • Organizer
      第23回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] Development of novel CD19 CAR-T cell therapy with enhanced antitumor efficacy against B cell malignancies2019

    • Author(s)
      三輪啓志、藤原 弘、赤堀 泰、王 立楠、奥村悟司、田中義正、加藤琢磨、宮原慶裕、珠玖 洋
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] Development of novel CD19 CAR-T cell therapy for B cell malignancies to improve its efficacy2019

    • Author(s)
      三輪啓志、藤原 弘、赤堀 泰、王 立楠、奥村悟司、田中義正、加藤琢磨、宮原慶裕、珠玖 洋
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07751
  • [Presentation] The Role of Reactive Oxygen Species in Apoptosis Induction of Mantle Cell Lymphoma (MCL) ; Inhibition of NADPH Oxidase 2 Induces Apoptosis in MCL2010

    • Author(s)
      Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, Masanori Daibata
    • Organizer
      第52回米国血液学会年次総会
    • Place of Presentation
      オーランド(フロリダ州)
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21591226
  • [Presentation] The Role of Reactive Oxygen Species in Apoptosis Induction of Mantle Cell Lymphoma(MCL); Inhibition of NADPH Oxidase 2 Induces Apoptosis in MCL2010

    • Author(s)
      Yuji Miura, Hiroshi Miwa, Toshihito Ohno, Miyako Haneda, Yoshitaka Hosokawa, Masakazu Nitta, Masanori Daibata
    • Organizer
      第52回米国血液学会年次総会
    • Place of Presentation
      米国フロリダ州オーランド
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21591226
  • 1.  KITA Kenkichi (90169847)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  Ishihara Mikiya (20707369)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  藤原 弘 (20398291)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  KATAYAMA Naoyuki (20185812)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SHIRAKAWA Shigeru (20026850)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  OHNO Toshiyuki (50194246)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  NISHIKAWA Masakatsu (30144257)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KOBAYASHI Tohru (00144246)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  赤堀 泰 (80221711)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  瀬尾 尚宏 (50283354)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MIURA Yuji (00345612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 12.  和田 英夫 (40158704)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  百瀬 文康 (20798326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  加藤 琢磨 (60224515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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