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MIZUNO Kazuya  水野 一也

ORCIDConnect your ORCID iD *help
Researcher Number 00219643
Other IDs
Affiliation (based on the past Project Information) *help 2008: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員
2007: 財団法人東京都医学研究機構, 副参事研究員
2003 – 2004: (財)東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員
2000 – 2004: Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Director of Department, 東京都神経科学総合研究所, 副参事研究員
1999: 財団法人 東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 … More
1997 – 1998: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 副参事研究員
1997: 財団法人東京都神経学科総合研究所, 微生物学・免疫学研究部門, 副参事
1997: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology & Immu, 微生物学・免疫学研究部門, 副参事
1996: (財)東京都神経科学総合研究所, 微生物学・免疫学, 副参事
1996: Tokyo Metropolitan Institute for Neuroscience, 微生物・免疫, 副参事
1995: (財)東京都神経科学総合研究所, 微生物学・免疫学, 主任研究員
1995: (財)東京都神経科学総合研究所, 微生物学・免疫学部門, 主任研究員
1993 – 1995: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 主任研究員
1993: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology & Immu, 微生物学・免疫学, 主任研究員
1992: 東京都神経研, 微生物学研究部門, 主任研究員
1992: 東京都神経科学総合研究所, 微生物学研究部門, 主任研究員
1990: Tokyo Metropolitan Institute for Neurosciences, Staff Scientist, 微生物学, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Biological Sciences / 免疫の制御機構 / Immunology / Immunology
Except Principal Investigator
Immunology / Biological Sciences / Experimental pathology
Keywords
Principal Investigator
チロシンホスファターゼ / SHP-1 / SLP-76 / アダプター分子 / BLNK / SLP-65 / シグナル伝達 / 細胞分化 / アイソフォーム / チロシンリン酸化 … More / MAPキナーゼ / アポトーシス / B細胞抗原受容体 / protein tyrosine phosphatase / glutathione S-transferase / 融合蛋白質 / 中枢神経系 / 神経分化 / P19細胞 / MPTPδ / HCP / SH2領域 / tyrosine phosphorylatio / SH2 domain / MAPkinase / apoptotic cell death / )SLP-76 / tyrosine phosphatase / adaptor proteins / apoptosis / B細胞 / JNK / CD22 / アポトー / signal transduction / B cells / adaptor molecules / c-Jun N terminal kinase … More
Except Principal Investigator
CD45 / チロシンホスファターゼ / アポトーシス / PEP / SLP-76 / SHP-1 / B細胞 / シグナル伝達 / Lyn / tyrosine phosphatase / アイソフォーム・スイッチ / MRPTP / B細胞活性化 / Lynキナーゼ / signal transduction / Apoptosis / MAPキナーゼ / チロシンキナーゼ / Csk / Cbp / 基質 / BLNK / SLP-65 / チロシンフォスファターゼ / HPTPS / HPTPZ / 免疫寛容 / Bリンパ球 / 増殖抑制 / SHIP / Gタンパク質共役受容体 / アデノシン受容体 / P2受容体 / ダイマー / BRET / 免疫沈降 / インターフェイス / 分子モデリング / プリン受容体 / アデノシン / ATP / 血小板 / 自己免疫病 / 抗体クラス変換 / チロシンフォスファタ-ゼ / Lybー2 / ILー4 / 抗体クラス / Lyー5(CD45) / 自己免疫 / モノクロ-ナル抗体による治療 / Autoimmunity / Antibody Class Switch / Protein Tyrosine Phosphatase / Lyb-2 / IL-4 / 中枢神経系 / MPTPδ / MPTPdelta / HPTPdelta / レセプター型チロシンフォスファターゼ / HPTP / Tyrosine phosphatase / B cell / Central nervous system / MPTP-delta / HCP / リンパ球 / tyrpsine phosphatase / lymphocyte / MAP kinase / カルシウム動員 / tyrosine kinase / substrate / アダプター分子 / adaptor / Src型チロシンキナーゼ / リピッドラフト / チロシンリン酸化 / GEM(ラフト) / マスト細胞 / Src-family kinases / GEM / lipid raft / tyrosine phosphorylation Less
  • Research Projects

    (20 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (7 People)
  •  Mechanism of G protein-coupled receptor oligomerization

    • Principal Investigator
      NAKATA Hiroyasu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Regulation of B cell activation and inactivation by the interaction between SHP-1 and adaptor moleculesPrincipal Investigator

    • Principal Investigator
      MIZUNO Kazuya
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Novel mechanisms of Src-family kinase regulation by CD45

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Molecular mechanisms for the regulation of BCR-mediated signal transduction by SHP-1 and adaptor proteins.Principal Investigator

    • Principal Investigator
      MIZUNO Kazuya
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  B細胞抗原受容体シグナリングにおけるSHP-1とアダプター分子の機能解析Principal Investigator

    • Principal Investigator
      水野 一也
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Signaling pathways regulated by PEST-domain tyrosine phosphatase PEP

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  Regulation of the immune system by tyrosine phosphatases and adaptor molecules

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  Role of tyrosine phosphatases in lymphocyte signaling

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Regulation of B cell antigen receptor-mediated signaling by SHP-1Principal Investigator

    • Principal Investigator
      MIZUNO Kazuya
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      免疫の制御機構
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  B細胞シグナル伝達機構のチロシンホスファターゼによる制御

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  チロシンホスファターゼによるB細胞活性他・不活性の制御機構

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  受容体型チロシンホスファターゼMPTPδの中枢神経系分化における役割の解析Principal Investigator

    • Principal Investigator
      水野 一也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Molecular Mechanism of CD45 in B cell signal transduction

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  チロシンホスファターゼによるB細胞活性化・不活化の制御機構

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  膜結合型チロシンホスファターゼ遺伝子のクローニングPrincipal Investigator

    • Principal Investigator
      水野 一也
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  B細胞免疫寛容誘導におけるチロシンホスファターゼの役割

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  膜結合型チロシンフォスファターゼ遺伝子のクローニングPrincipal Investigator

    • Principal Investigator
      水野 一也
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  レセプター型チロシンフォスファターゼのリンパ球活性化・腫瘍化における役割

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Receptor-type Protein Tyroshine Phosphatases Expressed in the Immune System and the Central Nervous System

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCES
  •  Regulatory Mechanisms of Antibody Class Expression and Therapy of Autoimmunity

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute for Neurosciences

All 2005 2004 2003

All Journal Article

  • [Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-indueed c-Jun N-terminal kinase activation.2005

    • Author(s)
      Mizuno, et al.
    • Journal Title

      European Journal of Immunology 35

      Pages: 644-654

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590446
  • [Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun NH2-terminal kinase activation.2005

    • Author(s)
      MIZUNO, K., TAGAWA, Y., WATANABE, N., OGIMOTO, M., YAKURA, H.
    • Journal Title

      Eur.J.Immunol. 35

      Pages: 644-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590446
  • [Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1,thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation2005

    • Author(s)
      Mizuno, et al.
    • Journal Title

      European Journal of Immunology 35

      Pages: 644-654

    • Data Source
      KAKENHI-PROJECT-15590446
  • [Journal Article] Impairment of B cell receptor-mediated Ca2+ influx, activation of mitogen-activated protein kinases and growth inhibition in CD72-deficient BAL-17 cells.2004

    • Author(s)
      OGIMOTO, M., ICHINOWATARI, G., QATANABE, N., TADA, N., MIZUNO, K., YAKURA, H.
    • Journal Title

      Int.Immunol. 16

      Pages: 971-982

    • NAID

      10013291776

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590446
  • [Journal Article] Dynamic regulation of Src-family kinases by CD45 in B cells.2003

    • Author(s)
      SHRIVASTAVA, P., KATAGIRI, T., OGIMOTO, M., MIZUNO, K., YAKURA, H.
    • Journal Title

      Blood 103

      Pages: 1425-1432

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590446
  • 1.  YAKURA Hidetaka (60166486)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 0 results
  • 2.  OGIMOTO Mami (80158609)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 3.  KATAGIRI Tatsuo (00233742)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 4.  KORETZKY Gary
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  NAKATA Hiroyasu (00041830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SCHRAVEN Burkhart
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  GARY Koretzk
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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