MIZUNO Kazuya 水野一也

Researcher Number	00219643
Other IDs
Affiliation (Current)	2020: 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員
Affiliation (based on the past Project Information) *help	2008: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 2007: 財団法人東京都医学研究機構, 副参事研究員 2003 – 2004: (財)東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 2000 – 2004: Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Director of Department, 東京都神経科学総合研究所, 副参事研究員 1999: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 副参事研究員 … More
Review Section/Research Field	Principal Investigator Experimental pathology / Biological Sciences / 免疫の制御機構 / Immunology / Immunology Except Principal Investigator Immunology / Biological Sciences / Experimental pathology
Keywords	Principal Investigator チロシンホスファターゼ / SHP-1 / SLP-76 / アダプター分子 / BLNK / SLP-65 / シグナル伝達 / 細胞分化 / アイソフォーム / チロシンリン酸化 … More Except Principal Investigator CD45 / チロシンホスファターゼ / アポトーシス / PEP / SLP-76 / SHP-1 / B細胞 / シグナル伝達 / Lyn / tyrosine phosphatase / アイソフォーム・スイッチ / MRPTP / B細胞活性化 / Lynキナーゼ / signal transduction / Apoptosis / MAPキナーゼ / チロシンキナーゼ / Csk / Cbp / 基質 / BLNK / SLP-65 / チロシンフォスファターゼ / HPTPS / HPTPZ / 免疫寛容 / Bリンパ球 / 増殖抑制 / SHIP / Gタンパク質共役受容体 / アデノシン受容体 / P2受容体 / ダイマー / BRET / 免疫沈降 / インターフェイス / 分子モデリング / プリン受容体 / アデノシン / ATP / 血小板 / 自己免疫病 / 抗体クラス変換 / チロシンフォスファタ-ゼ / Lybー2 / ILー4 / 抗体クラス / Lyー5(CD45) / 自己免疫 / モノクロ-ナル抗体による治療 / Autoimmunity / Antibody Class Switch / Protein Tyrosine Phosphatase / Lyb-2 / IL-4 / 中枢神経系 / MPTPδ / MPTPdelta / HPTPdelta / レセプター型チロシンフォスファターゼ / HPTP / Tyrosine phosphatase / B cell / Central nervous system / MPTP-delta / HCP / リンパ球 / tyrpsine phosphatase / lymphocyte / MAP kinase / カルシウム動員 / tyrosine kinase / substrate / アダプター分子 / adaptor / Src型チロシンキナーゼ / リピッドラフト / チロシンリン酸化 / GEM(ラフト) / マスト細胞 / Src-family kinases / GEM / lipid raft / tyrosine phosphorylation Less

Mechanism of G protein-coupled receptor oligomerization
- Principal Investigator
  
  NAKATA Hiroyasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Regulation of B cell activation and inactivation by the interaction between SHP-1 and adaptor moleculesPrincipal Investigator
- Principal Investigator
  
  MIZUNO Kazuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Novel mechanisms of Src-family kinase regulation by CD45
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Molecular mechanisms for the regulation of BCR-mediated signal transduction by SHP-1 and adaptor proteins.Principal Investigator
- Principal Investigator
  
  MIZUNO Kazuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
B細胞抗原受容体シグナリングにおけるSHP-1とアダプター分子の機能解析Principal Investigator
- Principal Investigator
  
  水野一也
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Signaling pathways regulated by PEST-domain tyrosine phosphatase PEP
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
Regulation of the immune system by tyrosine phosphatases and adaptor molecules
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
Role of tyrosine phosphatases in lymphocyte signaling
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Immunology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
Regulation of B cell antigen receptor-mediated signaling by SHP-1Principal Investigator
- Principal Investigator
  
  MIZUNO Kazuya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
B細胞シグナル伝達機構のチロシンホスファターゼによる制御
- Principal Investigator
  
  矢倉英隆
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
チロシンホスファターゼによるB細胞活性他・不活性の制御機構
- Principal Investigator
  
  矢倉英隆
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
受容体型チロシンホスファターゼMPTPδの中枢神経系分化における役割の解析Principal Investigator
- Principal Investigator
  
  水野一也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
Molecular Mechanism of CD45 in B cell signal transduction
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
チロシンホスファターゼによるB細胞活性化・不活化の制御機構
- Principal Investigator
  
  矢倉英隆
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
膜結合型チロシンホスファターゼ遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  水野一也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
B細胞免疫寛容誘導におけるチロシンホスファターゼの役割
- Principal Investigator
  
  矢倉英隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
膜結合型チロシンフォスファターゼ遺伝子のクローニングPrincipal Investigator
- Principal Investigator
  
  水野一也
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
レセプター型チロシンフォスファターゼのリンパ球活性化・腫瘍化における役割
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Institute for Neuroscience
Receptor-type Protein Tyroshine Phosphatases Expressed in the Immune System and the Central Nervous System
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCES
Regulatory Mechanisms of Antibody Class Expression and Therapy of Autoimmunity
- Principal Investigator
  
  YAKURA Hidetaka
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute for Neurosciences

All 2005 2004 2003

All Journal Article

[Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-indueed c-Jun N-terminal kinase activation.2005
- Author(s)
  Mizuno, et al.
- Journal Title
  
  European Journal of Immunology 35
  
  Pages: 644-654
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590446
[Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1,thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation2005
- Author(s)
  Mizuno, et al.
- Journal Title
  
  European Journal of Immunology 35
  
  Pages: 644-654
- Data Source
  KAKENHI-PROJECT-15590446
[Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun NH2-terminal kinase activation.2005
- Author(s)
  MIZUNO, K., TAGAWA, Y., WATANABE, N., OGIMOTO, M., YAKURA, H.
- Journal Title
  
  Eur.J.Immunol. 35
  
  Pages: 644-654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590446
[Journal Article] Impairment of B cell receptor-mediated Ca2+ influx, activation of mitogen-activated protein kinases and growth inhibition in CD72-deficient BAL-17 cells.2004
- Author(s)
  OGIMOTO, M., ICHINOWATARI, G., QATANABE, N., TADA, N., MIZUNO, K., YAKURA, H.
- Journal Title
  
  Int.Immunol. 16
  
  Pages: 971-982
- NAID
  10013291776
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590446
[Journal Article] Dynamic regulation of Src-family kinases by CD45 in B cells.2003
- Author(s)
  SHRIVASTAVA, P., KATAGIRI, T., OGIMOTO, M., MIZUNO, K., YAKURA, H.
- Journal Title
  
  Blood 103
  
  Pages: 1425-1432
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590446

1. YAKURA Hidetaka (60166486)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. OGIMOTO Mami (80158609)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
3. KATAGIRI Tatsuo (00233742)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
4. KORETZKY Gary

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAKATA Hiroyasu (00041830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SCHRAVEN Burkhart

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. GARY Koretzk

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIZUNO Kazuya 水野 一也

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Regulation of B cell activation and inactivation by the interaction between SHP-1 and adaptor moleculesPrincipal Investigator

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Molecular mechanisms for the regulation of BCR-mediated signal transduction by SHP-1 and adaptor proteins.Principal Investigator

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B細胞抗原受容体シグナリングにおけるSHP-1とアダプター分子の機能解析Principal Investigator

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Regulation of B cell antigen receptor-mediated signaling by SHP-1Principal Investigator

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受容体型チロシンホスファターゼMPTPδの中枢神経系分化における役割の解析Principal Investigator

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膜結合型チロシンホスファターゼ遺伝子のクローニングPrincipal Investigator

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MIZUNO Kazuya 水野一也