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YAKURA Hidetaka  矢倉 英隆

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Researcher Number 60166486
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Affiliation (based on the past Project Information) *help 2005: Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Institute for Neuroscience, Division of Neuronal Cell Function, Director, 東京都神経科学総合研究所, 参事研究員
2000 – 2004: Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Director of Molecular Research Division, 東京都神経科学総合研究所, 参事研究員
2000 – 2003: Tokyo Metropolitan Institute Neuroscience, Department of Immunology & Signal Transduction, Director of Molecular Research Division, 東京都神経科学総合研究所, 参事研究員
2001: 財団法人 東京都医学研究機構, 東京都神経科学総合研究所, 参事研究員
1999: 財団法人 東京都医学研究機構, 東京都神経科学総合研究所, 参事研究員 … More
1998: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology and Im, 微生物学・免疫学研究部門, 参事
1998: 東京都神経科学総合研究所, 微生物学・免疫学研究部門, 参事 (研究担当)
1997 – 1998: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 参事研究員
1997: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology & Immunology, Director of Molecular Research Division, 微生物学・免疫学研究部門, 参事
1996 – 1997: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 参事
1996: 東京都神経科学総合研究所, 微生物・免疫学, 参事
1996: Tokyo Metropolitan Institute for Neuroscience, 微生物学・免疫学, 参事
1995: (財)東京都神経科学総合研究所, 微生物学・免疫学研交部門, 副参事
1995: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門・副惨事研究員
1995: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology and lm, 微生物学・免疫学研究部門, 副参事
1994 – 1995: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 副参事
1993 – 1994: (財)東京都神経科学総合研究所, 微生物学・免疫学研究部門, 副参事研究員
1993: Tokyo Metropolitan Institute for Neuroscience, Department of Microbiology and Immunology, Director, 微生物学・免疫学研究部門, 副参事研究員
1992: (財)東京都神経科学総合研究所, 微生物学研究部門, 副参事
1992: 東京都神経科学総合研究所, 微生物学研究部門, 副参事研究員
1990: Tokyo Metropolitan Institute for Neurosciences, Member, 微生物学, 副参事
1990: (財)東京都神経科学総合研究所, 微生物学, 副参事研究員
1989: (財)東京都神経科学総合研究所, 微生物, 副参事
1988: Asahikawa Medical College, Department of Pathology, Assistant Professor, 医学部・第二病理, 助教授
1986 – 1987: Asahikawa Medical College, Associate Professor, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Immunology / Experimental pathology / アレルギー
Except Principal Investigator
Functional biochemistry / Immunology / 免疫の制御機構 / Experimental pathology
Keywords
Principal Investigator
CD45 / チロシンホスファターゼ / PEP / アポトーシス / シグナル伝達 / SLP-76 / SHP-1 / tyrosine phosphatase / B細胞活性化 / B細胞 … More / Lyn / Lyb-2 / signal transduction / Csk / アイソフォーム・スイッチ / MRPTP / Lynキナーゼ / Apoptosis / WEHI-231 / MAPキナーゼ / チロシンキナーゼ / Cbp / 基質 / BLNK / SLP-65 / マスト細胞 / チロシンフォスファターゼ / HPTPS / HPTPZ / 免疫寛容 / Bリンパ球 / 増殖抑制 / SHIP / 自己免疫病 / 抗体クラス変換 / チロシンフォスファタ-ゼ / Lybー2 / ILー4 / 抗体クラス / Lyー5(CD45) / 自己免疫 / モノクロ-ナル抗体による治療 / Autoimmunity / Antibody Class Switch / Protein Tyrosine Phosphatase / IL-4 / 中枢神経系 / MPTPδ / MPTPdelta / HPTPdelta / レセプター型チロシンフォスファターゼ / HPTP / Tyrosine phosphatase / B cell / Central nervous system / MPTP-delta / HCP / 核移行 / Crk / nuclear translocation / リンパ球 / tyrpsine phosphatase / lymphocyte / MAP kinase / カルシウム動員 / tyrosine kinase / substrate / アダプター分子 / adaptor / Src型チロシンキナーゼ / リピッドラフト / チロシンリン酸化 / GEM(ラフト) / Src-family kinases / GEM / lipid raft / tyrosine phosphorylation / アレルギー・ぜんそく / 免疫学 / 酵素 / 蛋白質 / プロテインホスファターゼ / PTP-PEST / PTPε / FcεRI / allergy, asthma / signal transudation / immunology / enzyme / protein / BSF-1 / 抗体クラスの調節 / Secand messenger / second messenger / BSF-1 (IL-4) / Immunoglobulin class regulation / B cell activation … More
Except Principal Investigator
CD45 / JNK / Src-family PTK / Lyn / チロシンホスファターゼ / リガンド / SHPS-1 / SHP-2 / B細胞抗原受容体 / シグナル伝達 / growth arrest / p38 / ERK / アポトーシス / SHP-1 / MAPキナーゼ / B細胞抗原受容体シグナル / Fyn / チロシン脱リン酸化酵素(PTP) / チロシンリン酸化酵素(PTK) / raft / CD40 / Lipid Raft / GEM / レセプター型チロシンホスファターゼ / CD45リガンド / CD45結合分子 / レセプター型チロシンフォスファターゼ / バキュロウィルスベクター / Receptor-type tyrosine phosphatase / CD45 ligand / CD45-binding molecule / 細胞内情報伝達 / プロテインホスファターゼ / セリン / トレオニンホスファターゼ / トウトマイシン / ノジュラリン / 長期増強 / アルツハイマー病 / オカダ酸 / Signal transduction / Protein phosphatase / Serine / threonine protein phosphatase / Tyrosine protein phosphatase / Tautomycin / B cell antigen receptor / B細胞抗原レセプター / B細胞 / 増殖抑制 / MAPキナーゼファミリー / NF-κB / B-cell antigen receptor / signal tranduction / チロシンリン酸化 / SH2領域 / SLP-76 / protein tyrosine phosphatase / tyrosine phosphorylatio / SH2 domain / MAPkinase / apoptotic cell death / ラフト / 成熟B細胞 / BCR signal / protein tyrosine phosphatase (PTP) / Protein tyrosine kinase (PTK) / tyrosine phosphatase / MAP kinases / B cell reseptor signal / PTP / PTK / HLA抗原 / クラス【II】抗原 / クラス【II】遺伝子 / HLA-D領域 / 疾患感受性 / 酵素免疫測定法 / 酵素抗体法 / HLA antigen / class <II> antigen / class <II> gene / HLA-D region / disease susceptibility Less
  • Research Projects

    (23 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (19 People)
  •  Regulation of mast Cell activation by tyrosine phosphatasePrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      アレルギー
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Novel mechanisms of Src-family kinase regulation by CD45Principal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Dynamic regulation of Src-family tyrosine kinases by CD45

    • Principal Investigator
      KATAGIRI Tatsuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  •  Search for CD45 ligand

    • Principal Investigator
      OGIMOTO Mami
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  Signaling pathways regulated by PEST-domain tyrosine phosphatase PEPPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  B cell signaling molecules which regulated by protein tyrosine phosphatase CD45

    • Principal Investigator
      KATAGIRI Tatsuo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Regulation of the immune system by tyrosine phosphatases and adaptor moleculesPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research
  •  Role of tyrosine phosphatases in lymphocyte signalingPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Regulation of B cell antigen receptor-mediated signaling by SHP-1

    • Principal Investigator
      MIZUNO Kazuya
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      免疫の制御機構
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  B細胞シグナル伝達機構のチロシンホスファターゼによる制御Principal Investigator

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Physiological significance of protein phosphatases on cellular signal transduction

    • Principal Investigator
      TAKEDA Masao
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Molecular mechanisms of PEST-domein tyrosine phosphatase PEP in B cellsPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  CD45により制御されるB細胞核内因子の解析

    • Principal Investigator
      OGIMOTO Mami
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      免疫の制御機構
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  チロシンホスファターゼによるB細胞活性他・不活性の制御機構Principal Investigator

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Molecular Mechanism of CD45 in B cell signal transductionPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  チロシンホスファターゼによるB細胞活性化・不活化の制御機構Principal Investigator

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  ldentification of CD 45 ligand

    • Principal Investigator
      OGIMOTO Mami
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  B細胞免疫寛容誘導におけるチロシンホスファターゼの役割Principal Investigator

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  レセプター型チロシンフォスファターゼのリンパ球活性化・腫瘍化における役割Principal Investigator

    • Principal Investigator
      矢倉 英隆
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo Metropolitan Institute for Neuroscience
  •  Receptor-type Protein Tyroshine Phosphatases Expressed in the Immune System and the Central Nervous SystemPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      TOKYO METROPOLITAN INSTITUTE FOR NEUROSCIENCES
  •  Regulatory Mechanisms of Antibody Class Expression and Therapy of AutoimmunityPrincipal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo Metropolitan Institute for Neurosciences
  •  Mechanisms of B Cell Activation Mediated by B Cell Stimulatory Factor-1 and Lyb-2Principal Investigator

    • Principal Investigator
      YAKURA Hidetaka
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Asahikawa Medical College
  •  Development of methods detecting HLA-D region genes and their products regulating disease susceptibility

    • Principal Investigator
      KATAGIRI Makoto
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Experimental pathology
    • Research Institution
      Asahikawa Medical College

All 2005 Other

All Journal Article

  • [Journal Article] PEP(PEST domain-enriched tyrosine phosphatase)/LYP(Lymphoid tyrosine phosphatase)2005

    • Author(s)
      矢倉 英隆
    • Journal Title

      生化学 77

      Pages: 1340-1340

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16616010
  • [Journal Article] PEP (PEST domain-enriched tyrosine phosphatase)/LYP (Lymphoid tyrosine phosphatase)2005

    • Author(s)
      矢倉 英隆
    • Journal Title

      生化学 77

      Pages: 1340-1340

    • Data Source
      KAKENHI-PROJECT-16616010
  • [Journal Article] Dynamic regulation of Src-family kinases by CD45 in B cells (*equal contributors)

    • Author(s)
      Shrivastava P*, Katagiri T*, Ogimoto M, Mizuno K, Yakura H
    • Journal Title

      Blood 103

      Pages: 1425-1432

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616010
  • [Journal Article] Impairment of B cell receptor-mediated Ca^<2+> influx, activation of mitogen-activated protein kinases and growth inhibition in CD72-deficient BAL-17 cells

    • Author(s)
      Ogimoto M, Ichinowatari G, Watanabe N, Tada N, Mizuno K, Yakura H
    • Journal Title

      Int.Immunol. 16

      Pages: 971-982

    • NAID

      10013291776

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616010
  • [Journal Article] SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation

    • Author(s)
      Mizuno K, Tagawa Y, Watanabe N, Ogimoto M, Yakura H
    • Journal Title

      Eur.J.Immunol. 35

      Pages: 644-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16616010
  • 1.  OGIMOTO Mami (80158609)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 0 results
  • 2.  KATAGIRI Tatsuo (00233742)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 0 results
  • 3.  MIZUNO Kazuya (00219643)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 0 results
  • 4.  KORETZKY Gary
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  TAKEDA Masao (40030853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  KASUGA Masato (50161047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MIYAMOTO Eishichi (50109659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TAMURA Shinri (20124604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KIKUCHI Kunimi (20006117)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KATAGIRI Makoto (10041823)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  IKEDA Hisami (90091561)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HIGA Toshio (10133836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  日野田 裕治 (10165128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  久野 高義 (50144564)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  渡邊 利雄 (60201208)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  一ノ渡 学 (00360701)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  MISHRA Kanchan Kumar (10360702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  SCHRAVEN Burkhart
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  GARY Koretzk
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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