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Kugiyama Kiyotaka  久木山 清貴

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KUGIYAMA Kiyotaka  久木山 清貴

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Researcher Number 00225129
Affiliation (based on the past Project Information) *help 2018 – 2020: 山梨大学, 大学院総合研究部, 教授
2014 – 2016: 山梨大学, 総合研究部, 教授
2011 – 2013: 山梨大学, 医学工学総合研究部, 教授
2007 – 2012: University of Yamanashi, 大学院・医学工学総合研究部, 教授
2003 – 2005: 山梨大学, 大学院・医学工学総合研究部, 教授 … More
2002: University of Yamanashi, Faculty of medicine, Professor, 医学部, 教授
2001: Kumamoto University School of Medicine, Assistant Professor, 医学部, 教授
2000: 熊本大学, 附属病院, 講師
1998 – 2000: Kumamoto University, School of Medicine, Assistant Professor, 医学部・附属病院, 講師
1998: 熊本大学, 医学部付属病院, 講師
1997 – 1998: 熊本大学, 医学部附属病院, 講師
1994 – 1996: Kumamoto University school of medicine, Division of Cardiology, Assistant Professor, 医学部, 講師
1993: 熊本大学, 医学部, 助手
1992: KUMAMOTO UNIVERSITY HOSPITAL, DIVISION OF CARDIOLOGY, ASSISTANT PROFESSOR, 医学部・附属病院, 助手
1991 – 1992: 熊本大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Biological Sciences / Basic Section 49030:Experimental pathology-related
Except Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine / Cardiovascular medicine
Keywords
Principal Investigator
血管内皮細胞 / 酸化ストレス / 心血管病 / Atherosclerosis / グルタチオン / 遺伝子多型 / 心筋梗塞 / 炎症 / Oxidized LDL / Endothelial cells … More / 動脈硬化 / NO / ノックアウトマウス / 受容体 / lysophosphatidylcholine / Protein Kinase C / fibrinolysis / protein kinase C / Lysophosphatidylcholine / Natriuretic Peptides / Oxidized LDL, / Oxysterol / Neutral Endopeptidase / Endothelial cell / Oxidative stress / 分泌型ホスホリパーゼA / 脂質メディエーター / 好中球 / 分泌型ホスホリパーゼA2受容体 / ホスホリパーゼA2 / TNF / lysolecithin / Tntercellular adhesion molecule-1 / Polymorphonuclear Leukocyte / Intercellular adhesion molecule-1 / Polymorphonuclear Leukecyte / endothelial cell / oxidized LDL / endothelin / endothelial cells / endothelium-dependent vasorelaxation / intercellular adhesion molecule-1 / Oxidized IDL / 低比重リポ蛋白 / リゾレシチン / プロテインキナーゼC / Phospholipase A_2 / phospholipase A_2 / Lysolecithin / Endothelial Cells / Gene Transcription / Phospholipase A2 / 平滑筋細胞 / マクロファージ / リポ蛋白 / Lipoproteins / Coronary artery disease / 冠動脈攣縮 / 狭心症 / 還元型グルタチオン / Coronary artery spasm / Angina pectoris / Reduced glutathione / Oxidized Low-density lipoproteins / 冠攣縮性狭心症 / glutathione / coronary spastic angina / oxidative stress / myocardial Infarction / endothelial function / polymorphism / レムナントリポ蛋白 / 内皮細胞機能障害 / メタボリックシンドローム / 頚動脈粥腫 / 高脂血症 / 中性脂肪 / 脳梗塞 / 虚血性心疾患 / Remnant lipoprotein / Cardiovascular diseases / Endothelial dysfunction / Metabolic syndrome / Carotid plaque / phospholipase A2 受容体 / バイオマーカー … More
Except Principal Investigator
Remote conditioning / 内皮機能 / 冠攣縮 / 狭心症 / 薬剤溶出性ステント / 血管内皮機能障害 / 内皮機能障害 / DES / 血管内皮機能 / 心不全 / バイオマーカー / remote conditioning / 拡張不全 / 冠攣縮硬化 / アセチルコリン / Mg / フィブリノペプチドA / エンドセリン / ヒスタミン / 冠循環 / サブスタンスP / tーPA / PAI / ACETYLCHOLINE / ACUTE MYOCARDIAL INFARCTION / CORONARY SAPSM / CORONARY THROMBOSIS / ENDITHELIN / FIHRINOPEPTIDE A / MAGNESIUM / VARIANT ANGINA / 一酸化窒素 / 一酸化窒素合成酸素 / 心筋梗塞 / 遺伝子変異 / 喫煙 / 危険因子 / 一酸化窒素合成酵素 / 遺伝子解析 / 冠動脈 / coronary spasm / angina pectoris / nitric oxide synthase / mutation / cigarette smoking / risk factor / polymorphism / transcrption factor / 平滑筋細胞 / 動脈硬化症 / 細胞分化 / 再狭窄 / 血球 / atherosaclerosis / vascular smooth muscle cell / differentiation / restenosis / blood cell / fibrosis Less
  • Research Projects

    (18 results)
  • Research Products

    (50 results)
  • Co-Researchers

    (34 People)
  •  Role of phospholipase A2 receptor in cardiovascular disease and drug developmentPrincipal Investigator

    • Principal Investigator
      Kugiyama Kiyotaka
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      University of Yamanashi
  •  Effects of remote ischemic conditioning on dilatory function in patients with heart failure.

    • Principal Investigator
      NAKAMURA Takamitsu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      University of Yamanashi
  •  Effects of remote ischemic conditioning on coronary endothelial vasomotor function in patients treated with drug eluting stents

    • Principal Investigator
      NAKAMURA Takamitsu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi
  •  A study of role of phospholipase A2 receptor in pathogenosis ofcardiovascular diseases and development of new drug for cardiovascular diseasesPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi
  •  A study of inhibitory effect of drug-eluting stent on the cardiacfunctional recovery from stunned or hibernated myocardium

    • Principal Investigator
      OBATA Jun-ei
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi
  •  A study of role of phospholipase A2 in pathogenosis of cardiovascular diseases and development of new drug for cardiovascular diseasesPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi
  •  酸化ストレス関連分子の遺伝子多型を基盤とする冠攣縮の病態解明と診断・治療法の開発Principal Investigator

    • Principal Investigator
      久木山 清貴
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Yamanashi
  •  酸化ストレス関連分子の遺伝子多型を基盤とする冠攣縮の病態解明と診断・治療法の開発Principal Investigator

    • Principal Investigator
      久木山 清貴
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Yamanashi
  •  Clinical significance of remnant lipoproteinemia as a therapeutic target of cardiovascular diseasesPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi
  •  Role of polymorphisms of γ-glutamylcysteine synthetase genes in pathogenesis of coronary spastic anginaPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      University of Yamanashi (Faculty of Medicine)
  •  Characterization of vascular smooth muscle progenitor cells in human peripheral blood

    • Principal Investigator
      SUGIYAMA Seigo
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Department of Cardiovascular Medicine, Kumamoto University School of Medicine
  •  Role of oxidative stress in pathogenesis of coronary spasm, a molecular biological and clinical studyPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Effects of remnant lipoproteins on functions of endothelial cells, smooth musclePrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Pathogenesis of coronary artery spasm : a study from the viewpoint of NO

    • Principal Investigator
      TASUE Hirofumi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Effects of lysolecithin on the regulation of gene transcription in endothelial cells and plasma levels of secretary type II phospholipase A2 in coronary artery diseasePrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  Effects of natriuretic peptides on the mechanisms of atherosclerosisPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University
  •  PATHOGENESIS AND CLINICAL SIGNIFICANCE OF CORONARY SPASM

    • Principal Investigator
      YASUE Hirofumi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KUMAMOTO UNIVERSITY HOSPITAL
  •  Effects of oxidized low density lipoprotein on vascular endothelial and smooth muscle cellsPrincipal Investigator

    • Principal Investigator
      KUGIYAMA Kiyotaka
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kumamoto University Hospital

All 2020 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005

All Journal Article Presentation Book

  • [Book] 内科学 狭心症2012

    • Author(s)
      尾畑純栄、久木山清貴
    • Publisher
      西村書店
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Book] 循環器疾患最新の治療 2012-2013 心筋梗塞の再発予防2012

    • Author(s)
      尾畑純栄、久木山清貴
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Group V secreted phospholipase A2 plays a protective role against aortic dissection.2020

    • Author(s)
      Kazuhiro Watanabe, Yoshitaka Taketomi, Yoshimi Miki, Kiyotaka Kugiyama, Makoto Murakami
    • Journal Title

      J Biol Chem

      Volume: 295 Pages: 10092-10111

    • DOI

      10.1074/jbc.ra120.013753

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07042, KAKENHI-PROJECT-16H02613, KAKENHI-PUBLICLY-20H04939, KAKENHI-PROJECT-18K07041, KAKENHI-PROJECT-19K07502, KAKENHI-PROJECT-19K22483
  • [Journal Article] Echolucency of the carotid artery is associated with short-term plaque progression and positive remodeling in the culprit coronary artery in AMI survivors.2017

    • Author(s)
      Futamata M, Matsuoka S, Shimizu T, Yoshizaki T, Obata JE, Nakamura T, Fujioka D, Watanabe Y, Nakamura K, Watanabe K, Kugiyama K
    • Journal Title

      J Cardiol.

      Volume: in press

    • DOI

      10.1016/j.jjcc.2017.01.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] Remnant lipoproteinemia predicts cardiovascular events in patients with type 2 diabetes and chronic kidney disease.2017

    • Author(s)
      Nguyen SV, Nakamura T, Uematsu M, Fujioka D, Watanabe K, Watanabe Y, Obata JE, Nakamura K, Kugiyama K
    • Journal Title

      J Cardiol.

      Volume: 69 Pages: 529-535

    • DOI

      10.1016/j.jjcc.2016.04.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] High levels of stromal cell-derived factor-1α predict secondary cardiac events in stable patients with a history of myocardial infarction.2017

    • Author(s)
      Matsuoka S, Uematsu M, Nakamura T, Shimizu T, Futamata M, Obata JE, Fujioka D, Nakamura K, Yoshizaki T, Kugiyama K
    • Journal Title

      J Cardiol.

      Volume: 69 Pages: 320-325

    • DOI

      10.1016/j.jjcc.2016.06.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] Myocardial Production of Plasminogen Activator Inhibitor-1 is Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction.2016

    • Author(s)
      Shimizu T
    • Journal Title

      J Atheroscler Thromb.

      Volume: 23(5) Pages: 557-566

    • DOI

      10.5551/jat.32300

    • NAID

      130005149016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] Echolucent Carotid Plaque is Associated with Future Renal Dysfunction in Patients with Stable Coronary Artery Disease2015

    • Author(s)
      Mochida T, Nakamura T, Nakamura K, Fujioka D, Saito Y, Obata JE, Watanabe Y, Watanabe K, Kugiyama K.
    • Journal Title

      J Atheroscler Thromb

      Volume: 21 Issue: 7 Pages: 000-000

    • DOI

      10.5551/jat.27276

    • NAID

      130005089132

    • ISSN
      1340-3478, 1880-3873
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461060, KAKENHI-PROJECT-26461059
  • [Journal Article] Assessment of carotid plaque neovascularization using quantitative analysis of contrast-enhanced ultrasound imaging is useful for risk stratification in patients with coronary artery disease.2015

    • Author(s)
      Nakamura J, Nakamura T, Deyama J, Fujioka D, Kawabata K, Obata JE, Watanabe K, Watanabe Y, Kugiyama K.
    • Journal Title

      Int J Cardiol.

      Volume: 195 Pages: 113-119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461060
  • [Journal Article] C-type lectin-like domain and fibronectin-like type II domain of phospholipase A(2) receptor 1 modulate binding and migratory responses to collagen2015

    • Author(s)
      Takahashi S
    • Journal Title

      FEBS Lett

      Volume: 589(7) Pages: 829-35

    • DOI

      10.1016/j.febslet.2015.02.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] Sustained myocardial production of stromal cell-derived factor-1α was associated with left ventricular adverse remodeling in patients with myocardial infarction.2015

    • Author(s)
      Uematsu M
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 309(10)

    • DOI

      10.1152/ajpheart.00493.2015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] Combined assessment of flow-mediated dilation of the brachial artery and brachial-ankle pulse wave velocity improves the prediction of future coronary events in patients with chronic coronary artery disease.2014

    • Author(s)
      Sugamata W
    • Journal Title

      J Cardiol

      Volume: 64(3) Pages: 179-184

    • DOI

      10.1016/j.jjcc.2014.01.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461059, KAKENHI-PROJECT-26461060
  • [Journal Article] High Remnant Lipoprotein Predicts Recurrent Cardiovascular Events on Statin Treatment After Acute Coronary Syndrome2014

    • Author(s)
      Nguyen SV, Nakamura T, Kugiyama K.
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 10 Pages: 2492-2500

    • DOI

      10.1253/circj.cj-14-0380

      10.1253/circj.CJ-14-0380

    • NAID

      130004690788

    • ISSN
      1346-9843, 1347-4820
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461060
  • [Journal Article] The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.2014

    • Author(s)
      Satoshi Ishii, Takamitsu Nakamura, Shuji Ozawa, Ayano Kobayashi, Daisuke Sano, Satoshi Okabe
    • Journal Title

      J Atheroscler Thromb

      Volume: 48(9) Pages: 4744-4749

    • DOI

      10.1021/es500578s

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26303011, KAKENHI-PROJECT-26461060
  • [Journal Article] Chronicdepletion of glutathione exacerbatesventricular remodelling and dysfunctionin the pressure-overloaded heart2013

    • Author(s)
      Watanabe Y, Watanabe K, Kobayashi T,Saito Y, Fujioka D, Nakamura T, Obata JE,Kawabata K, Mishina H, Kugiyama K
    • Journal Title

      Cardiovasc Res

      Volume: Vol. 97, No. 2 Pages: 282-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Journal Article] In-stent restenosis is inhibited in abare metal stent implanted distal to asirolimus-eluting stent to treat a long denovo coronary lesion with small distalvessel diameter2013

    • Author(s)
      Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata KI, KugiyamaK.
    • Journal Title

      Catheter CardiovascInterv

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Group X secretory PLA2 in neutrophilsplays a pathogenic role in abdominalaortic aneurysms in mice2012

    • Author(s)
      Watanabe K, Fujioka D, Saito Y, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Hanasaki K, KugiyamaK
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: Vol.302, No. 1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Journal Article] Disruption of group IVAcytosolic phospholipase A(2) attenuatesmyocardial ischemia-reperfusion injurypartly through inhibition ofTNF-α-mediated pathway2012

    • Author(s)
      Saito Y, Watanabe K, Fujioka D, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Kita Y, Shimizu T,Kugiyama K
    • Journal Title

      Am J PhysiolHeart Circ Physiol

      Volume: Vol.302,No.10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Journal Article] Usefulness of a collateral channel dilatorfor antegrade treatment of chronic totalocclusion of a coronary artery2012

    • Author(s)
      Obata JE, Nakamura T, Kitta Y, Saito Y,Sano K, Fujioka D, Kawabata K, Kugiyama K.
    • Journal Title

      J IntervCardiol

      Volume: Vol.25, No.6 Pages: 533-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Group V secretoryphospholipase A2 plays a pathogenic rolein myocardial ischaemia-reperfusioninjury2011

    • Author(s)
      Yano T, Fujioka D, Saito Y, KobayashiT, Nakamura T, Obata JE, Kawabata K,Watanabe K, Watanabe Y, Mishina H, TamaruS, Kugiyama K
    • Journal Title

      Cardiovasc Res

      Volume: Vol. 90,No. 2 Pages: 335-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Journal Article] Endothelialvasomotor dysfunction in the brachialartery predicts the short-termdevelopment of early stage renaldysfunction in patients with coronaryartery disease2011

    • Author(s)
      Nakamura T, Obata JE, Hirano M, KittaY, Sano K, Kobayashi T, Fujioka D, SaitoY, Yano T, Kawabata K, Watanabe K, WatanabeY, Mishina H, Kugiyama K.
    • Journal Title

      Int J Cardiol

      Volume: Vol.148, No.2 Pages: 183-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Short-term progression of maximumintima-media thickness of carotid plaque is associated with future coronary eventsin patients with coronary artery disease2011

    • Author(s)
      Hirano M, Nakamura T, Kitta Y,Takishima I, Deyama J, Kobayashi T,Fujioka D, Saito Y, Watanabe K, WatanabeY, Kawabata K, Obata JE, Kugiyama K
    • Journal Title

      Atherosclerosis

      Volume: Vol.215, No.2 Pages: 507-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury.2010

    • Author(s)
      Kobayashi T, Watanabe Y, Saito Y, Fujioka D, Nakamura T, Obata JE, Kitta Y, Yano T, Kawabata K, Watanabe K, Mishina H, Ito S, Kugiyama K.
    • Journal Title

      Cardiovasc Res. 85,4

      Pages: 785-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Inhibition of secretory hospholipase A2 activity attenuates lipopolysaccharide-induced acute lung injury in a mouse model.2010

    • Author(s)
      Sato R, Yamaga S, Watanabe K, Hishiyama S, Kawabata K, Kobayashi T, Fujioka D, Saito Y, Yano T, Watanabe K, Watanabe Y, Ishihara H, Kugiyama K.
    • Journal Title

      Exp Lung Res. 36,4

      Pages: 191-200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Assessment ofcarotid plaque echolucency in addition toplaque size increases the predictive valueof carotid ultrasound for coronaryevents in patients with coronaryartery disease and mild carotidatherosclerosis2010

    • Author(s)
      Hirano M, Nakamura T, Kitta Y, Sano K,Kodama Y, Kobayashi T, Fujioka D, Saito Y,Yano T, Watanabe K, Watanabe Y, KawabataK, Obata JE, Kugiyama K.
    • Journal Title

      Atherosclerosis

      Volume: Vol.211, No.2 Pages: 451-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Journal Article] Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.2009

    • Author(s)
      Kitta Y, Kugiyama K, et al.
    • Journal Title

      J Am Coll Cardiol 53(4)

      Pages: 323-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Novel insights of secretory phospholipase a(2) action in cardiology.2009

    • Author(s)
      Fujioka D, Kugiyama K.
    • Journal Title

      Trends Cardiovasc Med. 19,3

      Pages: 100-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Rapid improvement of carotid plaque echogenicity within 1 month of pioglitazone treatment in patients with acute coronary syndrome.2009

    • Author(s)
      Hirano M, Nakamura T, Kitta Y, Yano T, Kobayashi T, Sano K, Fujioka D, Saito Y, Kodama Y, Kawabata K, Nakamura K, Obata JE, Kugiyama K.
    • Journal Title

      Atherosclerosis. 203,2

      Pages: 483-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.2009

    • Author(s)
      Kitta Y, Obata JE, Nakamura T, Hirano M, Kodama Y, Fujioka D, Saito Y, Kawabata K, Sano K, Kobayashi T, Yano T, Nakamura K, Kugiyama K.
    • Journal Title

      J Am Coll Cardiol. 53,4

      Pages: 323-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] High serum levels of remnant lipoproteins predict ischemic stroke in patients with metabolic syndrome and mild carotid atherosclerosis.2009

    • Author(s)
      Nakamura T, Obata JE, Takano H, Kawabata K, Sano K, Kobayashi T, Fujioka D, Saito Y, Yano T, Kugiyama K.
    • Journal Title

      Atherosclerosis. 202,1

      Pages: 234-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.2008

    • Author(s)
      Fujioka D, Saito Y, Kobayashi T, Yano T, Tezuka H, Ishimoto Y, Suzuki N, Yokota Y, Nakamura T, Obata JE, Kanazawa M, Kawabata K, Hanasaki K, Kugiyama K.
    • Journal Title

      Circulation. 117,23

      Pages: 2977-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Reduction in myocardial ischemia-reperfusion injury in group X secretory phospholipase A_2-deficient mice2008

    • Author(s)
      Fujioka D, Kugiyama K, et. al.
    • Journal Title

      Ciruclation (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Measurement of the platelet retention rate in a column of collagen-coated beadsis useful for the assessment of efficacy of antiplatelet therapy.2008

    • Author(s)
      Mende A, Kugiyama K, et al
    • Journal Title

      Thromb Res 123(6)

      Pages: 856-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice.2008

    • Author(s)
      Fujioka D, Kugiyama K, et al.
    • Journal Title

      Circulation 117(23)

      Pages: 2977-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction.2007

    • Author(s)
      Obata JE, Kitta Y, Takano H, Kodama Y, Nakamura T, Mende A, Kawabata K, Saitoh Y, Fujioka D, Kobayashi T, Yano T, Kugiyama K.
    • Journal Title

      J Am Coll Cardiol. 50,14

      Pages: 1305-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Statin reverses reduction of adiponectin receptor expression in infarcted heart and in TNFα-treated cardiomyocytes in association with improved glucose uptake.2007

    • Author(s)
      Saito Y, Kugiyama K, et. al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 293(6)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Sirolimus-eluting stent implantation aggravates endothelial vasomotor dysfunction in the infarct-related coronary artery in patients with acute myocardial infarction.2007

    • Author(s)
      Obata J, Kugiyama K, et. al.
    • Journal Title

      J Am Coll Cardiol. 50(14)

      Pages: 1305-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Journal Article] Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease.2005

    • Author(s)
      Watanabe K, Kugiyama K, et al.
    • Journal Title

      J Am Coll Cardiol. 46・11

      Pages: 2022-2030

    • Data Source
      KAKENHI-PROJECT-15390244
  • [Journal Article] Endothelial vasomotor dysfunction in the brachial artery is associated with late in-stent coronary restenosis.2005

    • Author(s)
      Kitta Y, Kugiyama K, et al.
    • Journal Title

      J Am Coll Cardiol. 46・4

      Pages: 648-655

    • Data Source
      KAKENHI-PROJECT-15390244
  • [Journal Article] Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease.2005

    • Author(s)
      Koga H, Kugiyama K, et al.
    • Journal Title

      J Am Coll Cardiol. 45・10

      Pages: 1622-1630

    • Data Source
      KAKENHI-PROJECT-15390244
  • [Journal Article] Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome.2005

    • Author(s)
      Nakamura T, Kugiyama K, et al.
    • Journal Title

      Atherosclerosis. 181・2

      Pages: 321-327

    • Data Source
      KAKENHI-PROJECT-15390244
  • [Presentation] Chronic Depletion of GlutathioneExacerbates Ventricular Remodeling andDysfunction in Pressure Overloaded Heartin Mice Lacking the Glutamate-CysteineLigase Modifier Subunit2012

    • Author(s)
      Yosuke Watanabe,Kazuhiro Watanabe, Tsuyoshi Kobayashi,Yukio Saito, Daisuke Fujioka, TakamitsuNakamura, Jun-ei Obata, Kenichi Kawabata,Hideto Mishina, and Kiyotaka Kugiyama
    • Organizer
      米国心臓病学会
    • Place of Presentation
      ロサンゼルス、アメリカ
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Presentation] Remnant lipoproteinemia is a risk fornon-culprit attenuated coronary plaquesdetected by grayscale intravascularultrasound in patients with acute coronarysyndromes.2011

    • Author(s)
      Jyun-ei Obata, Yoshinobu Kitta, YukioSaito, Takamitsu Nakamura, Keita Sano,Daisuke Fujioka, Juntaro Deyama, ManabuUematsu, Ken-ichi Kawabata, NaohikoTsuyuguchi, Tetsuya Asakawa, AkinoriWatanabe, Ken Umetani, Takao Sawanobori,Tsukasa Ishihara, Kiyotaka Kugiyama
    • Organizer
      米国心臓病学会
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2011-11-15
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Presentation] Group X Secretory Phospholipase A2 inNeutrophils Plays a Pathogenic Role inAbdominal Aortic Aneurysms in Mice2011

    • Author(s)
      Kazuhiro Watanabe, Daisuke Fujioka, YukioSaito, Takamitsu Nakamura, Jun-ei Obata,Kenichi Kawabata, Yosuke Watanabe, HidetoMishina, Shun Tamaru, and KiyotakaKugiyama
    • Organizer
      米国心臓病学会
    • Place of Presentation
      オーランド、アメリカ
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Presentation] Group V Secretory Phospholipase A2Plays a Role in Myocardial IschemiaReperfusion Injury Through CytosolicPhospholipase A22010

    • Author(s)
      Toshiaki Yano, KenichiKawabata, Yukio Saito, Kazuhiro Watanabe,Yosuke Watanabe, Hideto Mishina, ShunTamaru, Junei Obata, and Kiyotaka Kugiyama
    • Organizer
      米国心臓病学会
    • Place of Presentation
      シカゴ、アメリカ
    • Data Source
      KAKENHI-PROJECT-22390158
  • [Presentation] Late catch-up recoveryfrom endothelial vasomotor dysfunction ininfarct-related coronary artery treatedwith sirolimus-eluting stent in patientswith acute myocardial infarction2010

    • Author(s)
      Jyun-ei Obata, Yoshinobu Kitta,Yasushi Kodama, Yukio Saitoh, Keita Sano,Mitsumasa Hirano, Tsuyoshi Kobayashi,Toshiaki Yano, Ken-ichi Kawabata,Kiyotaka Kugiyama.
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-07
    • Data Source
      KAKENHI-PROJECT-22590773
  • [Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group IV Cytosolic Phospholipase A2-deficient Mice Partly Due to Inhibition of TNFα-mediated Pathway to Cell Injury.2009

    • Author(s)
      Yukio Saito; Yousuke Watanabe; Hideto Mishina; Kazuhiro Watanabe; Toshiaki Yano; Tsuyoshi Kobayashi; Jun-ei Obata; Ken-ichi Kawabata; Takao Shimizu; Kiyotaka Kugiyama
    • Organizer
      American Heart Association Scientific Sessions.
    • Place of Presentation
      Orlando.
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Presentation] Reduction in Myocardial Ischemia-reperfusion Injury in Group V Secretory Phospholipase A2-deficient Mice.2009

    • Author(s)
      Toshiaki Yano; Keni-chi Kawabata; Yukio Saito; Tsuyoshi Kobayashi; Ryota Sato; Kazuhiro Watanabe; Yosuke Watanabe; Hideto Mishina; Jun-ei Obata; Kiyotaka Kugiyama
    • Organizer
      American Heart Association Scientific Sessions.
    • Place of Presentation
      Orlando.
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Presentation] Inhibition of Secretory Phospholipase A2 Activity Attenuates Acute Cardiogenic Pulmonary Congestion Induced by Isoproterenol Infusion in Mice with Post-Myocardial Infarction.2008

    • Author(s)
      Kenichi Kawabata, Tsuyoshi Kobayashi, Yousuke Watanabe, Kazuhiro Watanabe, Toshiaki Yano, Ryota Sato, Yukio Saito, Kazuto Nakamura, Kiyotaka Kugiyama
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      New Orleans
    • Data Source
      KAKENHI-PROJECT-19390209
  • [Presentation] Group X Secretory Phospholipase A2 has a Critical Role in Neutrophils Activation and Myocardial Ischemia-reperfusion Injury in Mice.2007

    • Author(s)
      Daisuke Fujioka, Kenichi Kawabata, Yoshikazu Ishimoto, Noriko Suzuki, Kohji Hansaki, Ryota Sato, Toshiaki Yano, Tsuyoshi Kobayashi, Yukio Saito, Masaki Kanazawa, Kiyotaka Kugiyama
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando
    • Data Source
      KAKENHI-PROJECT-19390209
  • 1.  KAWABATA Kenichi (30345706)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 21 results
  • 2.  YASUE Hirofumi (40174502)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  OBATA Jun-ei (60362076)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 26 results
  • 4.  WATANABE Kazuhiro (50535549)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 5.  UMETANI Ken (40262654)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  TEZUKA Hideo (70155456)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 7.  SAITO Yukio (50377511)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 8.  FUJIOKA Daisuke (70377513)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 9.  YANO Toshiaki (60456449)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 10.  NAKAMURA Takamitsu (60377512)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 11.  OGAWA Hisao (50177135)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  SUGIYAMA Seigo (90274711)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  長田 満 (40311691)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  中村 和人 (30456488)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 15.  KOBAYASHI Tsuyoshi (40402052)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 16.  WATANABE Yohsuke (90535551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 17.  MISHINA Hideto (70568021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 18.  TAKISHIMA Isao (80535534)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  HIRANO Mitsumasa (10436884)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 20.  KITTA Yoshinobu (10377509)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MATSUYAMA Kouzaburo (20229587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  FUJII Hiromi (40199295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  OKUMURA Ken (20185549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  YOSHIMURA Michihiro (30264295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  TAKANO Hajime (20362064)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  比江島 欣慎 (00313809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MIKI Yoshimi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  NAKAMURA Sunao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 29.  NAKAMURA Masashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 30.  WATANABE Akinori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 31.  SANO Daisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  TAKAHASHI Minoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  村上 誠
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  石井 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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