WATANABE Kazuhiro 渡辺一広

Researcher Number	50535549
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2020: 山梨大学, 大学院総合研究部, 臨床助教 2016: 山梨大学, 総合研究部, 病院助教 2015: 公益法人東京都医学総合研究所, その他、部局等, 研究員 2014 – 2015: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 2014: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野脂質代謝, 研究員 … More 2012 – 2013: 山梨大学, 医学部附属病院, 助教 2011 – 2012: 山梨大学, 医学部附属病院, 医員 2010: 山梨大学, 医学部・附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Basic Section 49030:Experimental pathology-related Except Principal Investigator Circulatory organs internal medicine / Laboratory medicine / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 心血管病 / リン脂質代謝 / ホスホリパーゼA2 / 大動脈解離 / 細胞外マトリックス / ホスホリパーゼA2受容体 / PLA2受容体 / 心筋梗塞 / 血管新生 / 線維芽細胞 … More / 急性大動脈解離 / 分泌性ホスホリパーゼA2 / Angiotensin II / 大動脈疾患 / 脂質代謝 / リシルオキシダーゼ … More Except Principal Investigator 炎症 / 心血管病 / 受容体 / バイオマーカー / 心筋梗塞 / ノックアウトマウス / 分泌型ホスホリパーゼA2受容体 / ホスホリパーゼA2 / TNF / 薬剤溶出性ステント / 血管内皮機能障害 / 内皮機能障害 / RNA診断 / 虚血性心疾患 / 不安定プラーク / RNA / 循環器病学 / ＲＮＡ診断 / phospholipase A2 受容体 Less

心血管病を抑制するリン脂質代謝の解明と新規心血管病治療・予防法開発の基盤構築Principal Investigator
- Principal Investigator
  
  渡辺一広
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Yamanashi
Role of phospholipase A2 receptor in cardiovascular disease and drug development
- Principal Investigator
  
  Kugiyama Kiyotaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Yamanashi
A study of role of phospholipid metabolism in cardiovascular diseasesPrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  University of Yamanashi
Search for RNA biomerker of cardiovascular disease
- Principal Investigator
  
  NAKAMURA Kazuto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Yamanashi
A study of role of phospholipase A2 and phospholipase A2 receptor in cardiovascular regeneration and development of new drug for cardiovascuar diseasePrincipal Investigator
- Principal Investigator
  
  WATANABE Kazuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  University of Yamanashi
A study of role of phospholipase A2 receptor in pathogenosis ofcardiovascular diseases and development of new drug for cardiovascular diseases
- Principal Investigator
  
  KUGIYAMA Kiyotaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Yamanashi
A study of inhibitory effect of drug-eluting stent on the cardiacfunctional recovery from stunned or hibernated myocardium
- Principal Investigator
  
  OBATA Jun-ei
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Yamanashi

All 2020 2015 2014 2013 2012 2011 2010

All Journal Article Presentation

[Journal Article] Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells2020
- Author(s)
  Watanabe Y, Watanabe K, Fujioka D, Nakamura K, Nakamura T, Uematsu M,
- Journal Title
  
  FASEB J
  
  Volume: 34 Pages: 5827-5837
- DOI
  10.1096/fj.201902575r
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07041
[Journal Article] Group V secreted phospholipase A2 plays a protective role against aortic dissection.2020
- Author(s)
  Kazuhiro Watanabe, Yoshitaka Taketomi, Yoshimi Miki, Kiyotaka Kugiyama, Makoto Murakami
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Pages: 10092-10111
- DOI
  10.1074/jbc.ra120.013753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07042, KAKENHI-PROJECT-16H02613, KAKENHI-PUBLICLY-20H04939, KAKENHI-PROJECT-18K07041, KAKENHI-PROJECT-19K07502, KAKENHI-PROJECT-19K22483
[Journal Article] c-type lectin domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen2015
- Author(s)
  Soichiro Takahashi, Kazuhiro Watanabe et al.
- Journal Title
  
  FEBS Letter
  
  Volume: 589 Pages: 829-835
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860591
[Journal Article] Lack of Phospholipase A2 Receptor Increases Susceptibility to Cardiac Rupture After Myocardial Infarction2014
- Author(s)
  Mishina H, Watanabe K, Tamaru S, Watanabe Y, Fujioka D, Takahashi S, Suzuki K, Nakamura T, Obata JE, Kawabata K, Yokota Y, Inoue O, Murakami M, Hanasaki K, Kugiyama K.
- Journal Title
  
  Circ Res
  
  Volume: 114 Pages: 493-504
- DOI
  10.1161/circresaha.114.302319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116005, KAKENHI-PROJECT-24390021, KAKENHI-PROJECT-25860591, KAKENHI-PROJECT-26461059
[Journal Article] Chronicdepletion of glutathione exacerbatesventricular remodelling and dysfunctionin the pressure-overloaded heart2013
- Author(s)
  Watanabe Y, Watanabe K, Kobayashi T,Saito Y, Fujioka D, Nakamura T, Obata JE,Kawabata K, Mishina H, Kugiyama K
- Journal Title
  
  Cardiovasc Res
  
  Volume: Vol. 97, No. 2 Pages: 282-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Disruption of group IVAcytosolic phospholipase A(2) attenuatesmyocardial ischemia-reperfusion injurypartly through inhibition ofTNF-α-mediated pathway2012
- Author(s)
  Saito Y, Watanabe K, Fujioka D, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Kita Y, Shimizu T,Kugiyama K
- Journal Title
  
  Am J PhysiolHeart Circ Physiol
  
  Volume: Vol.302,No.10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice2012
- Author(s)
  Watanabe K, et al
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 302
- DOI
  10.1152/ajpheart.00695.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Group X secretory PLA2 in neutrophilsplays a pathogenic role in abdominalaortic aneurysms in mice2012
- Author(s)
  Watanabe K, Fujioka D, Saito Y, NakamuraT, Obata JE, Kawabata K, Watanabe Y,Mishina H, Tamaru S, Hanasaki K, KugiyamaK
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: Vol.302, No. 1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Chronic depletion of glutathione exacerbates ventricular remodelling and dysfunction in the pressure-overloaded heart2012
- Author(s)
  Watanabe Y
- Journal Title
  
  Cardiovascular Research
  
  Volume: 97 Pages: 282-292
- DOI
  10.1093/cvr/cvs333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Group V secretoryphospholipase A2 plays a pathogenic rolein myocardial ischaemia-reperfusioninjury2011
- Author(s)
  Yano T, Fujioka D, Saito Y, KobayashiT, Nakamura T, Obata JE, Kawabata K,Watanabe K, Watanabe Y, Mishina H, TamaruS, Kugiyama K
- Journal Title
  
  Cardiovasc Res
  
  Volume: Vol. 90,No. 2 Pages: 335-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390158
[Journal Article] Endothelialvasomotor dysfunction in the brachialartery predicts the short-termdevelopment of early stage renaldysfunction in patients with coronaryartery disease2011
- Author(s)
  Nakamura T, Obata JE, Hirano M, KittaY, Sano K, Kobayashi T, Fujioka D, SaitoY, Yano T, Kawabata K, Watanabe K, WatanabeY, Mishina H, Kugiyama K.
- Journal Title
  
  Int J Cardiol
  
  Volume: Vol.148, No.2 Pages: 183-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590773
[Journal Article] Short-term progression of maximumintima-media thickness of carotid plaque is associated with future coronary eventsin patients with coronary artery disease2011
- Author(s)
  Hirano M, Nakamura T, Kitta Y,Takishima I, Deyama J, Kobayashi T,Fujioka D, Saito Y, Watanabe K, WatanabeY, Kawabata K, Obata JE, Kugiyama K
- Journal Title
  
  Atherosclerosis
  
  Volume: Vol.215, No.2 Pages: 507-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590773
[Journal Article] Assessment ofcarotid plaque echolucency in addition toplaque size increases the predictive valueof carotid ultrasound for coronaryevents in patients with coronaryartery disease and mild carotidatherosclerosis2010
- Author(s)
  Hirano M, Nakamura T, Kitta Y, Sano K,Kodama Y, Kobayashi T, Fujioka D, Saito Y,Yano T, Watanabe K, Watanabe Y, KawabataK, Obata JE, Kugiyama K.
- Journal Title
  
  Atherosclerosis
  
  Volume: Vol.211, No.2 Pages: 451-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590773
[Presentation] Chronic Depletion of GlutathioneExacerbates Ventricular Remodeling andDysfunction in Pressure Overloaded Heartin Mice Lacking the Glutamate-CysteineLigase Modifier Subunit2012
- Author(s)
  Yosuke Watanabe,Kazuhiro Watanabe, Tsuyoshi Kobayashi,Yukio Saito, Daisuke Fujioka, TakamitsuNakamura, Jun-ei Obata, Kenichi Kawabata,Hideto Mishina, and Kiyotaka Kugiyama
- Organizer
  米国心臓病学会
- Place of Presentation
  ロサンゼルス、アメリカ
- Data Source
  KAKENHI-PROJECT-22390158
[Presentation] Remnant lipoproteinemia is a risk fornon-culprit attenuated coronary plaquesdetected by grayscale intravascularultrasound in patients with acute coronarysyndromes.2011
- Author(s)
  Jyun-ei Obata, Yoshinobu Kitta, YukioSaito, Takamitsu Nakamura, Keita Sano,Daisuke Fujioka, Juntaro Deyama, ManabuUematsu, Ken-ichi Kawabata, NaohikoTsuyuguchi, Tetsuya Asakawa, AkinoriWatanabe, Ken Umetani, Takao Sawanobori,Tsukasa Ishihara, Kiyotaka Kugiyama
- Organizer
  米国心臓病学会
- Place of Presentation
  オーランド、米国
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22590773
[Presentation] Group X Secretory Phospholipase A2 inNeutrophils Plays a Pathogenic Role inAbdominal Aortic Aneurysms in Mice2011
- Author(s)
  Kazuhiro Watanabe, Daisuke Fujioka, YukioSaito, Takamitsu Nakamura, Jun-ei Obata,Kenichi Kawabata, Yosuke Watanabe, HidetoMishina, Shun Tamaru, and KiyotakaKugiyama
- Organizer
  米国心臓病学会
- Place of Presentation
  オーランド、アメリカ
- Data Source
  KAKENHI-PROJECT-22390158
[Presentation] Group V Secretory Phospholipase A2Plays a Role in Myocardial IschemiaReperfusion Injury Through CytosolicPhospholipase A22010
- Author(s)
  Toshiaki Yano, KenichiKawabata, Yukio Saito, Kazuhiro Watanabe,Yosuke Watanabe, Hideto Mishina, ShunTamaru, Junei Obata, and Kiyotaka Kugiyama
- Organizer
  米国心臓病学会
- Place of Presentation
  シカゴ、アメリカ
- Data Source
  KAKENHI-PROJECT-22390158

1. KUGIYAMA Kiyotaka (00225129)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. KAWABATA Kenichi (30345706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. OBATA Jun-ei (60362076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. YANO Toshiaki (60456449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. NAKAMURA Kazuto (30456488)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. SAITO Yukio (50377511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. WATANABE Yohsuke (90535551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. MISHINA Hideto (70568021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. TAKISHIMA Isao (80535534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. HIRANO Mitsumasa (10436884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 中村貴光 (60377512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 藤岡大佑 (70377513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MIKI Yoshimi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 村上誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

WATANABE Kazuhiro 渡辺 一広

Research Projects

Research Products

Co-Researchers

心血管病を抑制するリン脂質代謝の解明と新規心血管病治療・予防法開発の基盤構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of phospholipase A2 receptor in cardiovascular disease and drug development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study of role of phospholipid metabolism in cardiovascular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for RNA biomerker of cardiovascular disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of role of phospholipase A2 and phospholipase A2 receptor in cardiovascular regeneration and development of new drug for cardiovascuar diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of role of phospholipase A2 receptor in pathogenosis ofcardiovascular diseases and development of new drug for cardiovascular diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of inhibitory effect of drug-eluting stent on the cardiacfunctional recovery from stunned or hibernated myocardium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Group V secreted phospholipase A2 plays a protective role against aortic dissection.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] c-type lectin domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen2015

Author(s)

Journal Title

Data Source

[Journal Article] Lack of Phospholipase A2 Receptor Increases Susceptibility to Cardiac Rupture After Myocardial Infarction2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chronicdepletion of glutathione exacerbatesventricular remodelling and dysfunctionin the pressure-overloaded heart2013

Author(s)

Journal Title

Data Source

[Journal Article] Disruption of group IVAcytosolic phospholipase A(2) attenuatesmyocardial ischemia-reperfusion injurypartly through inhibition ofTNF-α-mediated pathway2012

Author(s)

Journal Title

Data Source

[Journal Article] Group X secretory PLA2 in neutrophils plays a pathogenic role in abdominal aortic aneurysms in mice2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Group X secretory PLA2 in neutrophilsplays a pathogenic role in abdominalaortic aneurysms in mice2012

Author(s)

WATANABE Kazuhiro 渡辺一広