NAKAO Kazuhiko 中尾一彦

Researcher Number	00264218
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Affiliation (based on the past Project Information) *help	2014 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 教授 2008: 長崎大学, 大学院・医歯薬学総合研究科, 教授 2007: Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor 2006: 長崎大学, 大学院・医師薬学総合研究科, 助教授 … More 2002 – 2004: Nagasaki Univ. Sch. Med., Associate Professor, 保健管理センター, 助教授 2001: Nagasaki University, Health Research Center, Lecturer, 保健管理サエンター, 講師 1998 – 2001: Nagasaki University Health Center, Lecturer, 保健管理センター, 講師 1997: 長崎大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Gastroenterology / Experimental pathology / General surgery
Keywords	Principal Investigator 肝細胞癌 / TRAIL / 肝癌 / STAT3 / Interferon-α / GITRL / PC61 / hepatoma / NF-κB / TNF-α … More / 15d-PGJ2 / siRNA / Survivin / ISGF3 / p48 / 微小環境変化 / 肝癌細胞 / DNA methyltransferase / SOCS3 / TGF-β / 肝星細胞 / 細胞増殖抑制 / 胞増殖抑制 / 抗腫瘍効果 / CDK4/6阻害薬 / GSK3β / GSK3 / AMPK / ワールブルグ効果 / cyclophosphamide / effector T cells(Teff) / regulatory T cells(Treg) / サイクロフォスファミド / エフェクターT細胞 / 制御性T細胞 / Hepatoma / TIAP遺伝子 / DNAワクチン / survivin / 樹状細胞 / Geranylgeranylacetone / IL-β / Viral hepatitis / B型肝炎ウイルス / ゲラニルゲラニルアセトン / インターロイキン-1β / インターフェロン / ウイルス性肝炎 / Recombinant retrovirus / alpha-fetoprotein (AFP) / Hepatocellular carcinoma / Gene therapy / ヒトAFP / レトロウイルスベクター / 組換えレトロウィルス / レトロウイルス / α-Fetoprotein(AFP) / 遺伝子治療 / microRNA-122 / 上皮間葉移行 / VEGF / 分岐鎖アミノ酸 / インスリン … More Except Principal Investigator 肝細胞癌 / Hepatoma / 肝癌 / 遺伝子治療 / TRAIL / Interferon-α / hepatoma / 分子標的 / NF-kB / NF-κB / survivin / PKR / p48 / GMCSF / MCSF / Apoptosis / Radiation / アポトーシス / 放射線 / Hepatocellular carcinoma / Ras gene / Rb gene / HMGI-C / 血管新生 / 肝再生 / PTHrP / 53BP-1 / carcinogenesis / genomic instability / 53Bp1 / 遺伝子不安定性 / 脂肪酸 / 線維化 / 脂肪肝 / NASH / 遺伝子損傷応答 / 発癌 / 53BP1 / DNA損傷応答 / NAFLD / 非アルコール性脂肪肝炎 / STI571 / stem cell / gene therapy / targeting / 肝細胞がん / STI1571 / 分化誘導 / Bone marrow stem cell / 骨髄細胞 / 骨髄幹細胞 / interferon-α / eIF2 α / eIF2α / IFN-α / 肝癌細胞 / eIF2-α / MEKK / Carcinogenesis / Stem Cell / HUMARA assay / 前癌病変 / 肝細胞 / 脱分化 / 幹細胞 / α-fetoprotein (AFP) / DNA vaccine / 樹状細胞 / α-fetoprotein / Cell-basedワクチン療法 / DNAワクチン療法 / 自殺遺伝子 / AFP / DNAワクチン / Dormancy / Angiogenesis / Suicide Gene Therapy / Adenovines vector / α-Fetoprotein / Anti-neoantigogenesis / Angiostatin / Gene therapy / 肝癌培養細胞 / アテノウイルスベクター / アルファーフェトプロテイン / 血管新生阻害因子 / アンギオスタチン / Degenerated PCR / Preneoplastic lesic / Oval cell / Receptor-type tyrosine kinase / 受容体型チロシンキナーゼ / 受容体チロシンキナーゼ / 発癌過程 / 受容体チロンキシナーゼ / Silencer / Albumin / alpha-Fetoprotein / サイレンサー活性 / アルファフェトプロテイン / サイレンサー / アルブミン / アルファ-フェトプロテイン / Transgenic model / liver cirrhosis / liver specific promoter / liver regeneration / 癌化 / PTHrP受容体 / トランスジェニックマウス / 肝硬変 / 肝特異的プロモーター / サイクロスポリン / タクロリムス / 免疫抑制剤 / 細胞内刺激伝達 / C型肝炎 / インターフェロン / カルシニューリン阻害剤 / 肝移植 Less

Epigenetic suppression of SOCS3 and enhanced activation of STAT3 in activated hepatic stellate cells.Principal Investigator
- Principal Investigator
  
  Nakao Kazuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagasaki University
Basic study of anti-tumor immunity induction by CDK4 / 6 inhibitor for hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagasaki University
Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression.
- Principal Investigator
  
  AKAZAWA Yuko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Anti-tumor effect against hepatoma cells by suppressing the Warburg effect by AMPK activation and GSK3 inhibitionPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Epithelial-mesenchymal transition and autophagy of hepatoma cells by the microenvironment changePrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
The influence of immunosuppressant to interferon signaling in hepatocyte
- Principal Investigator
  
  ICHIKAWA Tatsuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cellsPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Anti-tumor effectof 15d-PGJ2 on human hepatoma cellsPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Role of hepatic stem cells derived from the bone marrow in the histogenesis of hepatocellular
- Principal Investigator
  
  HAMASAKI Keisuke, 石川博基
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Epigenetic Regulation Implicates Hypoxia-resistance of Hepatoma Stem Cell Population.
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Interferon-a sensitizes human hepatoma cells to TRAIL-iduced apoptosis through DRS upregulation and NF-κB inactivation
- Principal Investigator
  
  ISHII Nobuko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Molecular Analysis of Stem Cell in Hepatocarcinogenesis
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University School of Medicine
Gene therapy against hepatocellular carcinoma using p48 gene
- Principal Investigator
  
  EJIMA Eri, 中田惠輔
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Anticancer therapy against hepatocellular carcinoma by survivin targetingPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
α-fetoprotein - specific tumor immynity induced by plasmid DNA vaccination
- Principal Investigator
  
  ISHII Nobuko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Gene therapy for hepatocellular carcinoma using an endogenous antineoangiogenetic factor, angiostatin
- Principal Investigator
  
  NAKATA Keisuke
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Radio-inducible Dormancy in Hepatoma Gene Therapy
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University School of Medicine
Biochemical modulation of interferon-αaction in viral hepatitisPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Molecular pathological analysis of the expression of receptor-type tyrosine kinase in hepatocellular carcinoma
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University School of Medicine
Molecular Analysis of PTHrP in Hepatic Regeneration
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Retrovirus-mediated gene therapy for hepatocellular cacrinomaPrincipal Investigator
- Principal Investigator
  
  NAKAO Kazuhiko
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University
Identification of alpha-fetoprotein silencer and analysis of its regulatory mechanisms
- Principal Investigator
  
  NAKATA Keisuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University

All 2019 2018 2017 2016 2015 2014 2008 2007 2006 2004 2003

All Journal Article Presentation

[Journal Article] Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression.2019
- Author(s)
  Akazawa Y, Nakashima R, Matsuda K, Okamaoto K, Hirano R, Kawasaki H, Miuma S, Miyaaki H, Malhi H, Abiru S, Itoh M, Kondo H, Fukuoka J, Nakao K, Nakashima M.
- Journal Title
  
  Modern pathology
  
  Volume: 印刷中 Issue: 7 Pages: 997-1007
- DOI
  10.1038/s41379-019-0218-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09362
[Journal Article] Ketone bodies as a predictor of prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization.2018
- Author(s)
  Sasaki R, Taura N, Miyazoe Y, Yamamichi S, Nakashiki S, Yamashima M, Suehiro T, Honda T, Shibata H, Ozawa E, Miuma S, Akazawa Y, Miyaaki H, Matsumoto T, Nakao K, Ashizawa K.
- Journal Title
  
  Nutrition
  
  Volume: 57 Pages: 97-103
- NAID
  120006988032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09362
[Journal Article] Geranylgeranylacetone attenuates fibrogenic activity and induces apoptosis in cultured human hepatic stellate cells and reduces liver fibrosis in carbon tetrachloride-treated mice2018
- Author(s)
  Senoo Takemasa、Sasaki Ryu、Akazawa Yuko、Ichikawa Tatsuki、Miuma Satoshi、Miyaaki Hisamitsu、Taura Naota、Nakao Kazuhiko
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 18 Issue: 1
- DOI
  10.1186/s12876-018-0761-7
- NAID
  120006987314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09362
[Journal Article] To die or not to die: death signaling in nonalcoholic fatty liver disease2018
- Author(s)
  Akazawa Yuko、Nakao Kazuhiko
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 8 Pages: 893-906
- DOI
  10.1007/s00535-018-1451-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09362
[Journal Article] Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice2017
- Author(s)
  Ikuko Takahara, Yuko Akazawa, Maiko Tabuchi, Katsuya Matsuda, Hisamitsu Miyaaki, Youko Kido, Yasuko Kanda, Naota Taura, Ken Ohnita, Fuminao Takeshima, Yusuke Sakai, Susumu Egushi, Masahiro Nakashima, Kazuhiko Nakao
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 3 Pages: e0170591-e0170591
- DOI
  10.1371/journal.pone.0170591
- NAID
  120006987538
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05908, KAKENHI-PROJECT-16K09362, KAKENHI-PROJECT-26461916, KAKENHI-PROJECT-16K08714
[Journal Article] Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis2017
- Author(s)
  Takaki Hiroko、Akazawa Yuko、Kido Youko、Morishita Mami、Honda Takuya、Shibata Hidetaka、Miuma Satoshi、Miyaaki Hisamitsu、Taura Naota、Kondo Hisayoshi、Nakao Kazuhiko
- Journal Title
  
  Medical Science Monitor
  
  Volume: 23 Pages: 4526-4532
- DOI
  10.12659/msm.903210
- NAID
  120006987388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09362
[Journal Article] Significance of miRNA-122 in chronic　hepatitis C patients with serotype 1 on interferon therapy.2015
- Author(s)
  Kamo Y, Ichikawa T, Miyaaki H, Uchida S, Yamaguchi T, Shibata H, Honda T, Taura N, Isomoto H, Takeshima F, Nakao K.
- Journal Title
  
  Hepatol Res.
  
  Volume: 45(1) Issue: 1 Pages: 88-96
- DOI
  10.1111/hepr.12317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590983
[Journal Article] Antitumor function of microRNA-122 against　hepatocellular carcinoma.2014
- Author(s)
  Nakao K, Miyaaki H, Ichikawa T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 49(4) Issue: 4 Pages: 589-93
- DOI
  10.1007/s00535-014-0932-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590983
[Journal Article] Tum-1, a tumstatin fragment, gene delivery into hepatocellular carcinoma suppresses tumor growth through inhibiting angiogenesis.2008
- Author(s)
  Goto T, Ishikawa H, Matsumoto K, Nishimura D, Kusaba M, Taura N, Shibata H, Miyaaki H, Ichikawa T, Hamasaki K, Nakao K, Maeshima Y, Eguchi K.
- Journal Title
  
  Int J Oncol 33
  
  Pages: 33-40
- NAID
  120006983902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Clinicopathological study of nonalcoholic fatty liver disease in Japan : the risk factors for fibrosis2008
- Author(s)
  Miyaaki H, Ichikawa T, Nakao K, Yatsuhashi H, Furukawa R, Ohba K, Omagari K, Kusumoto Y, Yanagi K, Inoue O, Kinoshita N, Ishibashi H, Yano M, Eguchi K.
- Journal Title
  
  Liver int 28
  
  Pages: 519-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Predictive value of the phosphorylation of signal transducers and activators of transcription in the outcome of interferon therapy for chronic hepatitis2008
- Author(s)
  Miyaaki H, Ichikawa T, Nakao K, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Eguchi K
- Journal Title
  
  C.Intervirology 51
  
  Pages: 394-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders2008
- Author(s)
  Nakamura H, Usa T, Motomura M, Ichikawa T, Nakao K, Kawasaki E, Tanaka M, Ishikawa K, Eguchi K
- Journal Title
  
  J Endocrinol Invest 31
  
  Pages: 861-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Significance of trans-hepatic arterial chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus2008
- Author(s)
  Akiyama M, Miyaaki H, Miuma S, Shibata H, Fujimoto M, Takeshita S, Ozawa E, Ichikawa T, Nakao K, Eguchi K.
- Journal Title
  
  Oncol Rep 20
  
  Pages: 353-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon-induced antiviral protein in human hepatocyte cells2008
- Author(s)
  Hirano K, Ichikawa T, Nakao K, Matsumoto A, Miyaaki H, Shibata H, Eguchi S, Takatsuki M, Ikeda M, Yamasaki H, Kato N, Kanematsu T, Ishii N, Eguchi K
- Journal Title
  
  Liver Transpl 14
  
  Pages: 292-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease2007
- Author(s)
  Tatsuki, Ichikawa, Kazuhiko, Nakao, Keisuke, Hamasaki, Ryuji, Furukawa, Shotarou Tsuruta, Yasuo, Ueda, Naota, Taura, Hidetaka, Shibata, Masumi, Fujimoto, Kan, Toriyama, Katsumi, Eguchi
- Journal Title
  
  Hepatology International 1(2)
  
  Pages: 287-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis2007
- Author(s)
  Mariko, Kusaba, Kazuhiko, Nakao, Takashi, Goto, Disuke, Nishimura, Hiroshi Kawashimo, Hidetaka, Shibata, Yasuhide, Motoyoshi, Naota, Taura, Tatsuki, Ichikawa, Keisuke, Hamasaki, Katsumi, Eguchi
- Journal Title
  
  Journal of Hepatology 47(4)
  
  Pages: 546-555
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Polymorphisms of interleukin-1β in Japanese patients with hepatitis B virus infection2007
- Author(s)
  Kiyoshi, Migita, Yumi, Maeda, Seigo, Abiru, Minoru, Nakamura, Atsushi, Komori, Seiji, Miyazoe, Kazuhiko, Nakao, Hiroshi, Yatsuhashi, Katsumi, Eguchi, Hiromi, Ishibashi
- Journal Title
  
  Journal of Hepatology 46(3)
  
  Pages: 381-386
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007
- Author(s)
  Yuji, Nagayama, Wataru, Hase, Yasuhide, Motoyoshi, Ohki, Saitoh, Rintaroh, Sogawa, Kazuhiko, Nakao
- Journal Title
  
  Oncology Reports 17(5)
  
  Pages: 1269-1273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Eguchi K Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis2007
- Author(s)
  Kusaba M, Nakao K, Goto T, Nishimura D, Kawashimo H, Shibata H, Motoyoshi Y, Taura N, Ichikawa T, Hamasaki K
- Journal Title
  
  J Hepatol. 2007 47
  
  Pages: 546-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591487
[Journal Article] DHMEQ, a novel NF-kB inhibitor, induces apoptosis and cell-cycle arrest in human hepatoma cells2006
- Author(s)
  Disuke, Nishimura, Hiroki, Ishikawa, Kojiro, Matsumoto, Hidetaka, Shibata, Yasuhide, Motoyoshi, Mariko, Fukuta, Hiroshi, Kawashimo, Takashi, Goto, Naota, Taura, Tatsuki, Ichikawa, Keisuke, Hamasaki, Kazuhiko, Nakao, Kazuo, Umezawa, Katsumi, Eguchi
- Journal Title
  
  International Journal of Oncology 29(3)
  
  Pages: 713-719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Different mechanisms for anti-tumor effects of low- and high-dose cyclophosphamide2006
- Author(s)
  Yasuhide, Motoyoshi, Kazuhisa, Kaminoda, Ohki, Saitoh, Keisuke, Hamasaki, Kazuhiko, Nakao, Nobuko, Ishii, Yuji, Nagayama, Katsumi, Eguchi
- Journal Title
  
  Oncology Reports 16(1)
  
  Pages: 141-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Association between liver fibrosis and insulin sensitivity in chronic hepatitis C patients2006
- Author(s)
  Naota, Taura, Tatsuki, Ichikawa, Keisuke, Hamasaki, Kazuhiko, Nakao, Daisuke, Nishimura, Takashi, Goto, Mariko, Fukuta, Hiroshi, Kawashimo, Masumi, Fujimoto, Koichiro, Kusumoto, Yasuhide, Motoyoshi, Hidetaka, Shibata, Norio, Abiru, Hironori, Yamasaki, Katsumi, Eguchi
- Journal Title
  
  American Journal of Gastroenterology 101(12)
  
  Pages: 2752-2759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis2006
- Author(s)
  Nakao Kazuhiko, et. al.
- Journal Title
  
  Oncology Reports 16・2
  
  Pages: 389-392
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis2006
- Author(s)
  Nakao Kazuhiko, et al.
- Journal Title
  
  Oncology Reports 16・2
  
  Pages: 389-392
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Survivin downregulation by siRNA sensitizes human hepatoma cells to TRAIL-induced apoptosis2006
- Author(s)
  Kazuhiko, Nakao, Keisuke, Hamasaki, Tatsuki, Ichikawa, Arima, Kazuhiko, Katsumi, Eguchi, Nobuko, Ishii
- Journal Title
  
  Oncology Reports 16(2)
  
  Pages: 389-392
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739
[Journal Article] Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma.2004
- Author(s)
  Matsumoto K, Ishikawa H, Nishimura D, Hamasaki K, Nakao K, Eguchi K.
- Journal Title
  
  Hepatology 40(1)
  
  Pages: 252-259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590660
[Journal Article] Bone marrow engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular carcinoma.2004
- Author(s)
  Ishikawa H, Nakao K, Matsumoto K, Nishimura D, Ichikawa T, Hamasaki K, Eguchi K.
- Journal Title
  
  Gut 53(6)
  
  Pages: 884-889
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590661
[Journal Article] Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells.2003
- Author(s)
  Ohata K, Ichikawa T, Nakao K, Shigeno M, Nishimura D, Ishikawa H, Hamasaki K, Eguchi K.
- Journal Title
  
  FEBS Letters 553(3)
  
  Pages: 304-308
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590660
[Journal Article] Interferon-α sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-κB inactivation.2003
- Author(s)
  Shigeno M, Nakao K, Ichikawa T, Suzuki K, Kawakami A, Abiru S, Miyazoe M, Nakagawa Y, Ishikawa H, Hamasaki K, Nakata K, Ishii N, Eguchi K.
- Journal Title
  
  Oncogene 22(11)
  
  Pages: 1653-1662
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590660
[Presentation] ROLE OF p53-BINDING PROTEIN 1 IN NON-ALCOHOLIC FATTY LIVER DISEASE2019
- Author(s)
  Hiroko Kasawaki, Yuko Akazawa, Kazuhiko Nakao
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] H. pylori 胃炎におけるBH3-only 蛋白Bim の役割．2019
- Author(s)
  赤澤祐子、松田勝也、中尾一彦、中島正洋
- Organizer
  日本病理学会総会
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] 53BP1 蛍光免疫染色によるNAFLD 肝細胞遺伝子損傷応答の可視化．2019
- Author(s)
  赤澤祐子、宮明寿光、中尾一彦
- Organizer
  日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] Palmitate Induces DNA Damage Response Dependent on Oxidative Stress and Caspases in Hepatocytes.2018
- Author(s)
  Hirano R, Akazawa Y, Matsuda K, Miyaaki H, Fukuoka J, Nakashima M, Nakao K
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] Nuclear expression of p53-binding protein 1, a DNA damage response molecule, is increased in NAFLD liver2017
- Author(s)
  Ryoma Nakashima, Yuko Akazawa, Katsuya Matsuda, Kazuhiko Nakao, Masahiro Nakashima
- Organizer
  AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] ＮASHは肝細胞核内におけるp53 binding protein-1フォーカス集積を増加させる2016
- Author(s)
  赤澤祐子、宮明寿光、中尾一彦
- Organizer
  日本肝臓病学会
- Place of Presentation
  東京ベイ幕張ホール（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-16K09362
[Presentation] Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cells2007
- Author(s)
  Yasuhide, Motoyoshi, Yuji, Nagayama, Wataru, Hase, Ohki, Saitoh, Rintaroh, Sogawa, Kazuhiko, Nakao
- Organizer
  14th Japan-Korea Hepatitis Meetin
- Place of Presentation
  Fukuoka, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590739

1. NAKATA Keisuke (40217740)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMASHITA Shunichi (30200679)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. HAMASAKI Keisuke (50333521)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
4. OHTSURU Akira (00233198)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. ISHII Nobuko (20088868)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. ICHIKAWA Tatsuki (80346949)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
7. MIYAAKI Hisamitsu (20437891)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. MATSUYAMA Toshifumi (30165922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. EJIMA Eri (30231187)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 玉田陽子 (70393460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SEKINE Ichiro (60039922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITO Masahiro (30184691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUKAZAKI Tomoo (50315230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIRABE Susumu (40264220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAGAYAMA Yuji (30274632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. AKAZAWA Yuko (80582113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
17. 石川博基 (30346960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中島正洋 (50284683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. 三馬聡 (30437892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 馬詰裕之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 有馬哲彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SAKAI Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAO Kazuhiko 中尾 一彦

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Epigenetic suppression of SOCS3 and enhanced activation of STAT3 in activated hepatic stellate cells.Principal Investigator

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Basic study of anti-tumor immunity induction by CDK4 / 6 inhibitor for hepatocellular carcinomaPrincipal Investigator

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Anti-tumor effect against hepatoma cells by suppressing the Warburg effect by AMPK activation and GSK3 inhibitionPrincipal Investigator

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Epithelial-mesenchymal transition and autophagy of hepatoma cells by the microenvironment changePrincipal Investigator

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Distinct responses of two hepatocellular carcinoma cell lines of a similar origin to immunotherapies targeting regulatory or effector T cellsPrincipal Investigator

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Anti-tumor effectof 15d-PGJ2 on human hepatoma cellsPrincipal Investigator

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Anticancer therapy against hepatocellular carcinoma by survivin targetingPrincipal Investigator

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NAKAO Kazuhiko 中尾一彦