SEKINE Ichiro 関根一郎

Researcher Number	60039922
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008: 長崎大学, 大学院・医歯薬学総合研究科・原研病理, 教授 2007 – 2008: Nagasaki University, Graduate School of Biomedical Sciences, Professor 2006: Nagasaki University, Professor and Chair, 大学院医歯薬学総合研究科, 教授 2003 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 2002: 長崎大学, 医学部, 教授 1996 – 2000: 長崎大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Experimental pathology / Human pathology / Human pathology Except Principal Investigator Medical sociology / Human pathology / 環境影響評価(含放射線生物学) / Experimental pathology / Experimental pathology
Keywords	Principal Investigator p53 / PTHrP / ret / β-catenin / PTC / 胃がん / p21 / グレリン / レプチン / IGF-1 … More / Ghrelin / H.Pylori / BMI / PTHrP受容体 / 血管平滑筋細胞 / 血管内皮細胞 / 再狭窄血管病変 / 血管新生 / 内皮細胞 / PTH / 動脈硬化 / 再狭窄 / 石灰化 / VSMC / PTHrP receptor / Endothelial cells / Angiogenesis / Antisense therapy / 肝癌 / 受容体チロンキシナーゼ / 発癌過程 / 受容体チロシンキナーゼ / 受容体型チロシンキナーゼ / Hepatocellular carcinoma / Receptor-type tyrosine kinase / Oval cell / Preneoplastic lesic / Degenerated PCR / 放射性発癌 / 基底細胞癌 / 甲状腺がん / PTC3 / 遠隔医療支援システム / 放射線発癌 / 甲状腺癌 / 皮膚法 / Semipalatinsk Nuclear Testing Site(SNTS) / basal cell carcinoma / thyroid cancer / telemedicine / セミパラチンスク核実験場 / EBウイルス / セミパラチンクス核実験場 / セミパラチンスク / 放射線誘発癌 / 遺伝子バンク / Semipalatinsk / Stomach cancer / EB virus / 胃切除後症候群 / 成長ホルモン / Gastric cancer / Leptin / Growth Hormone / 萎縮性胃炎 / ガストリン / H. Pylori / Gastretomy / Gastritis / Appetite / Growth hormon / IGF-I / がん幹細胞 / SP分画 / non-SP分画 / 放射線感受性 / SP細胞分画 / c-Ab1 / NF-kB / 放射線抵抗性 / セネッセンス / Cancer stem cell / SP cell / Non-SP cell / THRB … More Except Principal Investigator 甲状腺がん / アンギオポエチン / eosinophil cationic protein / interleukin-11 / apoptosis / Tie / チェルノブイリ / 遠隔医療 / 医学教育 / 胃腸管間質腫瘍 / TIE 受容体 / TIE受容体 / GIST / Ang-1 / Ang-2 / Tie-2 / 小児甲状腺がん / 放射性ヨード / 動物実験 / 放射線 / 動物モデル / 内部被ばく / Thyroid tumor / Radiation / Iodine-131 / Animal Model / 放射線大腸炎 / 潰瘍性大腸炎 / 高血圧自然発症ラット / 大腸炎 / 核塵 / Eosinophil cationic protein / 放射性腸炎 / DSS腸炎 / GVHD / インターロイキン-11 / ポラポレジンク / 放射線腸炎 / 酢酸胃潰瘍 / アポトーシス / ケフィア / マクロファージ / radiation colitis / ulcerative colitis / spontaneously hypertensive rats / colitis / nuclear dust / 大腸癌 / 浸潤 / 分化度 / Colorectal cancer / Angiopoietin / Invasion / Differentiation Less

Expression and role of Angiopoietin family and Tie receptors in Gastrointestinal stromal tumor (GIST)
- Principal Investigator
  
  NAKAYAMA Toshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
Patho-physiological Analysis of Radio-resistant Cancer Stem CellsPrincipal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
チェルノブイリ周辺地域における遠隔医療・教育システム確立にむけた調査
- Principal Investigator
  
  TAKAMURA Noboru
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical sociology
- Research Institution
  Nagasaki University
The expression of Angiopoietin and Tie receptor in colorectal cancer and its roles in proliferation and invasion
- Principal Investigator
  
  NAKAYAMA Toshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Molecular pathological analysis of the ghrelin expression in H. Pylori associated diseases.Principal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
Molecular Pathological Analysis of Digestive Cancers around Semipalatinsk Nuclear Testing SitePrincipal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Molecular Pathological Study on the dynamics of Ghrelin in patients with gastric diseasesPrincipal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagasaki University
Molecular pathological study on dysregulation of apoptotic machinery in intractable colitis and therapeutic drugs
- Principal Investigator
  
  SHICHIJO Kazuko
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Collaboration on the late effect of radiation around Semipalatinsk nuclear testing sitePrincipal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Molecular pathological analysis of the expression of receptor-type tyrosine kinase in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University School of Medicine
Project for development of in vivo rat model internal 131-iodine exposure in thyroid grand
- Principal Investigator
  
  YAMASHITA Shunichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Nagasaki University School of Medicine
Molecular Analysis of PTHrP in Vascular Smooth Muscle Cell.Principal Investigator
- Principal Investigator
  
  SEKINE Ichiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University

All 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] 病理学概論第2版2003
- Author(s)
  関根一郎
- Total Pages
  153
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Book] 病理学概論第2版2003
- Author(s)
  関根一郎
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14406002
[Book] An introduction to pathology, the second edition2003
- Author(s)
  Sekine Ichiro(Ed)
- Publisher
  Ishiyaku Publishers, Inc,
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Alteration of p53-binding protein 1 expression during skin carcinogenesis : association with genomic instability2008
- Author(s)
  Naruke, Y., Nakashima, M., Suzuki, K., Matsuu-Matsuyama, M., Shichijo, K., Kondo, H., Sekine, I
- Journal Title
  
  Cancer Sci 99(5)
  
  Pages: 946-51
- NAID
  10024006035
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression Patterns of Angiopoietin-1, -2, and Tie-2 Receptor in Ulcerative Colitis Support Involvement of the Angiopoietin/ Tie Pathway in the Progression of Ulcerative Colitis2008
- Author(s)
  Yoshizaki A, Nakayama T, Naito S, Sekine I
- Journal Title
  
  Dig Dis Sci Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590353
[Journal Article] Incidence of multiple primary cancers in Nagasaki atomic bomb survivors : association with radiation exposure.2008
- Author(s)
  Nakashima, M., Kondo, H., Miura, S., Soda, M., Hayashi, T., Matsuo, T., Yamashita, S., Sekine, I
- Journal Title
  
  Cancer Sci 99(1)
  
  Pages: 87-92
- NAID
  10024001017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Foci formation of P53-binding protein 1 in thyroid tumors : activation of genomic instability during thyroid carcinogenesis.2008
- Author(s)
  Nakashima, M., Suzuki, K., Meirmanov, S., Naruke, Y., Matsuu-Matsuyama, M., Shichijo, K., Saenko, V., Kondo, H., Hayashi, T., Ito, M., Yamashita, S., Sekine, I
- Journal Title
  
  Int J Cancer 122(5)
  
  Pages: 1082-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] X radiation up-regulates the occurrence and the multiplicity of invasive carcinomas in the intestinal tract of Anc(min/+) mice2007
- Author(s)
  Nakayama, T., Yamazumi, K., Uemura, T., Yoshizaki, A., Yakata, Y., Matsuu-Matsuyama, M., Shichijo, K., Sekine, I
- Journal Title
  
  Radiat Res 168(4)
  
  Pages: 433-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma2007
- Author(s)
  Yamaguchi, E., Nakayama, T., Nanashima, A., Matsumoto, K., Yasutake, T., Sekine, I., Nagayasu, T
- Journal Title
  
  Tbhoku J Exp Med 213(1)
  
  Pages: 41-50
- NAID
  10019861320
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of apoptotic epithelial cells in biopsy specimens of patients with colitis2007
- Author(s)
  Shichijo, K., Shin, T., Wen, CY., Nakayama, T., Nakashima, M., Kaimovich, AG., Matsuyama, M., Sekine, I
- Journal Title
  
  Dig Dis Sci 52(9)
  
  Pages: 2037-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expression of p-STAT3 in human gastric carcinoma : significant correlation in tumour invasion and prognosis2007
- Author(s)
  Yakata, Y., Nakayama, T., Yoshizaki, A., Kusaba, T., Inoue, K., Sekine, I
- Journal Title
  
  Int J Oncol 30(2)
  
  Pages: 437-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] The protective effect of interleukin-11 on the cell death induced by X-ray irradiation in cultured intestinal epithelial cell2007
- Author(s)
  Uemura, T., Nakayama, T., Kusaba, T., Yakata, Y., Yamazumi, K., Matsuu-Matsuyama, M., Shichijo, K., Sekinem, I
- Journal Title
  
  J Radiat Res 48(2)
  
  Pages: 171-7
- NAID
  110006241805
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Sucralfate protects intestinal epithelial cells from radiation-induced aproptosis in rats2006
- Author(s)
  Matsuu-Matsuyama, M., Shichijo, K., Okaichi, K., Ishii, K., Wen, CY., Fukuda, E., Nakayama, T., Nakashima, M., Okumura, Y., Sekine, I
- Journal Title
  
  J Radiat Res 47(1)
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis2006
- Author(s)
  Yoshizaki, A., Nakayama, T., Naito, S., Wen, CY., Sekine, T
- Journal Title
  
  World J Gastroenterol 12(35)
  
  Pages: 5687-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335
[Journal Article] Sucralfate protects intestinal epithelial cells from radiation-induced apoptosis in rats2006
- Author(s)
  Matsuu-M M, Shichijo.K, _Okaichi K, Ishii K, Wen CY, Fukuda E, Nakayama T, Nakashima M, Okumura Y, Sekine I
- Journal Title
  
  P Radiat Res (in press)
- NAID
  110004701145
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] The suppressing mechanism through bystander response of Interleukin-11 on radiation-induced colitis in rats2005
- Author(s)
  Shichijo K, Ihara M, Fukuda E, Matsuyama-M M, Wen CY, Nakashima M, Nakayama T, Sekine I
- Journal Title
  
  Gastroenterology 128(Supp 12 : No.4)
- NAID
  10017571177
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Antibody to eosinophil_cationic protein suppresses dextran sulfate sodium-induced colitis in rats2005
- Author(s)
  Shichijo K, Makiyama K, Wen.CY, Matsuu M, Nakayama T, Nakashima T, Sekine I
- Journal Title
  
  World J Gastroenterol 11(29)
  
  Pages: 4505-4510
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis2005
- Author(s)
  Niino D, Nakashima M, Kondo H, Ito M, Matsuu M, Shichijo K, Nakayama T, Tomonaga-M, Sekine I
- Journal Title
  
  Pathol Res Pract 200(11-12)
  
  Pages: 775-781
- NAID
  10020560319
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Dextran Sulfate Sodium大腸炎における核塵の発現と意義2005
- Author(s)
  七條和子, 慎武, 松山睦美, 温春陽, 中山敏幸, 中島正洋, 関根一郎
- Journal Title
  
  Ulcer Research 32(2)
  
  Pages: 154-155
- NAID
  10016832784
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Sympathetic hyperfunction causes increased sensitivity of the autonomic nervous system to whole-body X irradiation2005
- Author(s)
  Matsuu M, Shichijo K, Ikeda Y, Ito M, Naito S, Okaichi K, Nakashima M, Nakayama T, Sekine I
- Journal Title
  
  Radiat Res 163(2)
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] ラット急性放射線腸炎に対するポラプレジンクの効果2004
- Author(s)
  永安忠則, 七條和子, 中山敏幸, 中島正洋, 関根一郎
- Journal Title
  
  長崎医学会雑誌 79(28)
  
  Pages: 260-262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] 同種造血幹細胞移植における皮膚GVHDの免疫組織学的検討2003
- Author(s)
  新野大介, 関根一郎, 七條和子, 松鵜睦, 中山敏幸, 中島正洋, 他
- Journal Title
  
  長崎医学会雑誌 78(2)
  
  Pages: 50-54
- NAID
  110000374257
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Overexpreddion of heat shock Protein 70 in stomach of stress-induced gastric ulcer-resistant rats2003
- Author(s)
  Shichijo K, Ihara K, Matsuu M, Ito M, Okumura Y, Sekine I
- Journal Title
  
  Digestive Disease and Science 48(2)
  
  Pages: 340-348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Journal Article] Immunohistochemical study of cutaneous graft-versus-host disease(GVHD) after allogeneic stem cell tansplantaion2003
- Author(s)
  Niino D, Sekine I, Shichijo K, et al.
- Journal Title
  
  Nagasakiigakukaizassi 78(2)
  
  Pages: 50-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570193
[Presentation] Detection of radiosensitivity in thyroid tissue2007
- Author(s)
  Nakashima, M., Vladimir, Saenko, Matsuyama, M., Naruke, Y., Suzuki, K., Yamashita, S., Ichiro, Sekine
- Organizer
  11th Japan Congress of Endocrine Pathology
- Place of Presentation
  Sapporo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590335

1. OHTSURU Akira (00233198)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. YAMASHITA Shunichi (30200679)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. NAKAYAMA Toshiyuki (30284673)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
4. TAKAMURA Noboru (30295068)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. NAKASHIMA Masahiro (50284683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
6. ITO Masahiro (30184691)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SICHIJO Kazuko (90136656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. MATSUYAMA Toshifumi (30165922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NAMBA Hiroyuki (80237635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAO Kazuhiko (00264218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJII Toru (60136661)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIBATA Yoshisada (40010954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MITSUTAKE Norisato (50404215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 青柳潔 (80295071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 温春陽 (80346957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SEKINE Ichiro 関根 一郎

Research Projects

Research Products

Co-Researchers

Expression and role of Angiopoietin family and Tie receptors in Gastrointestinal stromal tumor (GIST)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Patho-physiological Analysis of Radio-resistant Cancer Stem CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

チェルノブイリ周辺地域における遠隔医療・教育システム確立にむけた調査

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The expression of Angiopoietin and Tie receptor in colorectal cancer and its roles in proliferation and invasion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological analysis of the ghrelin expression in H. Pylori associated diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Pathological Analysis of Digestive Cancers around Semipalatinsk Nuclear Testing SitePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Pathological Study on the dynamics of Ghrelin in patients with gastric diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological study on dysregulation of apoptotic machinery in intractable colitis and therapeutic drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Collaboration on the late effect of radiation around Semipalatinsk nuclear testing sitePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological analysis of the expression of receptor-type tyrosine kinase in hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Project for development of in vivo rat model internal 131-iodine exposure in thyroid grand

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Analysis of PTHrP in Vascular Smooth Muscle Cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 病理学概論 第2版2003

Author(s)

Total Pages

Publisher

SEKINE Ichiro 関根一郎

[Book] 病理学概論第2版2003