NAKANISHI Masayuki 中西雅之

… Alternative Names

中西雅之ナカニシマサユキ

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Researcher Number	00281048
Other IDs
Affiliation (Current)	2025: 松山大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2008 – 2015: 松山大学, 薬学部, 准教授 1998 – 2006: 岐阜大学, 工学部, 助手 2004: 岐阜大学, 工学部, 助教授 2002: GIFU UNIVERSITY FACULTY OF ENGINEERING RESEARCH ASSOCIATE, 工学部, 教授 1996: 岐阜大学, 工学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Parasitology (including sanitary zoology) / Parasitology (including Sanitary zoology) / Functional biochemistry / Biological Sciences Except Principal Investigator 医薬分子機能学 / Drug development chemistry / Orthopaedic surgery / Biological Sciences
Keywords	Principal Investigator Trypanosoma brucei / 糖転移酵素 / RNase L / 抗ウィルス機構 / 2-5A / GnT-I / N-結合型糖鎖 / 原虫 / トリパノソーマ / 糖タンパク質 … More / 糖鎖 / トリパノソーマ原虫 / 寄生原虫 / 無細胞タンパク質合成 / アフリカ睡眠病 / 抗マラリア薬 / 非メバロン酸経路 / 熱帯熱マラリア / 感染症 / 生体内メチル化 / ヌクレオシド系阻害剤 / S-アデノシルホモシステイン / Plasmodium falciparum / マラリア / ファージディスプレイ / 分子擬態 / 2-5Aシステム / アンキリンリピート / 構造機能相関 / 補酵素特異性 / カルボニル還元酵素 / 短鎖型脱水素酵素ファミリー … More Except Principal Investigator SAH hydrolase / 遺伝子組換え酵素 / 炭素環ヌクレオシド / 抗ウイルス薬 / 2-5A / antisense / 抗マラリア薬 / アシクロヌクレオシド / messenger RNA / oligomer / ribonuclease / 2-5A-antisense / メッセンジャーRNA / 核酸オリゴマー / リボヌクレアーゼ / 2-5A-アンチセンス / アンチセンス核酸 / anti-viral drug / 2-5A-antisense chimera / Rnase L / interferon / 2-5A system / 抗ウイルス作用 / RNaseL / アンチセンス / 2-5Aアンチセンス・キメラ / RNase L / インターフェロン / 2-5Aシステム / inhibitor of protein synthesis / carbocyclic nucleoside / affinity-labeling probe / mechanism-based inhibitor / recombinant enzyme / acyclonucleoside / anti-viral agent / 遺伝子組換酵素 / 抗ウィルス薬 / タンパク質合成阻害 / アフィニティーラベル化プローブ / 機構依存型阻害剤 / 化合物ライブラリー / in silico薬物設計 / ニューロトロフィン受容体 / ニューロトロフィン / ソーチリン / RAP(receptor-associated protein) / p75受容体 / アポトーシス / ニューロトロフィン前駆体 / 脊髄損傷修復 / 医薬品開発 / X線結晶構造解析 / 酵素阻害薬 / マラリア / ノルアリステロマイシン / ネプラノシンA / 酵素阻害剤 / 熱帯熱マラリア原虫 / mRNAのキャップ構造 / 抗癌薬 / SAHase Less

Elucidation of a synthetic pathway for complex-type N-linked glycans in Trypanosoma bruceiPrincipal Investigator
- Principal Investigator
  
  Nakanishi Masayuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Matsuyama University
Function and biosynthetic machinary of complex N-glycans expressing in Trypanosoma bruceiPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Masayuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Matsuyama University
脊髄損傷修復への応用をめざした新たな神経保護薬の創生
- Principal Investigator
  
  古川美子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Matsuyama University
マラリア原虫における非メバロン酸経路の解明Principal Investigator
- Principal Investigator
  
  中西雅之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Gifu University
X線結晶構造解析を基盤とする熱帯熱マラリア原虫酵素の特異的阻害薬の開発
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Development of a new generation of 2-5A-antisense and its property for the regulation of gene expression.
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
マラリア原虫由来S-アデノシルホモシステイン加水分解酵素の挿入配列の機能解明Principal Investigator
- Principal Investigator
  
  中西雅之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
STUDY ON DRUG-DESIGN AND SYNTHESIS OF NOVEL 2-5A-ANTISENSE CHIMERAS
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  GIFU UNIVERSITY
組換えSAHaseを標的とするマラリア治療薬の開発研究
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
抗ウィルスマシーナリー-2-5Aシステム-の構造生物学Principal Investigator
- Principal Investigator
  
  中西雅之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
2-5Aを擬態する抗ウィルス性ペプチドの開発Principal Investigator
- Principal Investigator
  
  中西雅之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
SAHaseの触媒機能探索と医薬品開発を指向するリード化合物の分子設計
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
STUDY ON CATALYTIC REACTION MECHANISM OF ADENOSYLHOMOCYSTEINE HYDRLASE AND SYNTHESIS OF THEIR MECANISM -BASED INHIBITORS
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  GIFU UNIVERSITY
変異導入法によるマウス肺カルボニル還元酵素の反応機構解析Principal Investigator
- Principal Investigator
  
  中西雅之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University

All 2015 2014 2013 2012 2011 2010 2005 2004 Other

All Journal Article Presentation

[Journal Article] 2-5A Induces a Conformational Change in the Ankyrin-repeat Domain of RNase L.2005
- Author(s)
  中西雅之
- Journal Title
  
  PROTEINS (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390036
[Journal Article] 2-5A Induces a Conformational Change in the Ankyrin-repeat Domain of RNase L.2005
- Author(s)
  Masayuki Nakanishi
- Journal Title
  
  PROTEINS : Structure, Function, and Bioinformatics. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390036
[Journal Article] Mutational Analyses of Plasmodium falciparum and Human S-adenosylhomocysteine Hydrolases2005
- Author(s)
  Masayuki Nakanishi
- Journal Title
  
  Mol.Biochem.Parasitol. 143
  
  Pages: 146-151
- Data Source
  KAKENHI-PROJECT-16017239
[Journal Article] Contribution of Tyr712 and Phe716 to the activity of human RNase L2004
- Author(s)
  Masayuki Nakanishi
- Journal Title
  
  Eur.J.Biochem. 271
  
  Pages: 2737-2744
- Data Source
  KAKENHI-PROJECT-15390036
[Journal Article] Contribution of Tyr712 and Phe716 to the Activity of Human RNase L.2004
- Author(s)
  Masayuki Nakanishi
- Journal Title
  
  European Journal of Biochemistry. 271
  
  Pages: 2737-2744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390036
[Journal Article] Contribution of Tyr712 and Phe716 to the Activity of Human RNase L.2004
- Author(s)
  中西雅之
- Journal Title
  
  European Journal of Biochemistry 271
  
  Pages: 2737-2744
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390036
[Presentation] 糖転移酵素GnT-Iのアフリカトリパノソーマ原虫とヒトにおける相違2015
- Author(s)
  中西　雅之，木下　かおり，真鍋　綾香，日野　真美，野元　裕
- Organizer
  日本分子生物学会・日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] アフリカトリパノソーマ原虫が有する糖転移酵素TbGT11の糖鎖修飾が複合糖鎖の形成に及ぼす影響2015
- Author(s)
  真鍋　綾香，木下　かおり，日野　真美，野元　裕，中西　雅之
- Organizer
  日本薬学会中国四国支部学術大会
- Place of Presentation
  高知市文化プラザかるぽーと（高知県・高知市）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] Trypanosoma bruceiの糖鎖合成酵素TbGnT-Iの活性発現にはN-結合型糖鎖が必要である2015
- Author(s)
  中西　雅之
- Organizer
  分子寄生虫・マラリア研究フォーラム
- Place of Presentation
  帯広畜産大学原虫病研究センター（北海道・帯広市）
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] Trypanosoma brucei由来N-アセチルグルコサミン転移酵素-I（GnT-I）の分離とプロテオーム解析2014
- Author(s)
  中西　雅之，野元　裕
- Organizer
  第83回　日本寄生虫学会大会
- Place of Presentation
  愛媛大学
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] Trypanosoma bruceiが有するN-アセチルグルコサミン転移酵素-I（GnT-I）の性状解析2013
- Author(s)
  中西　雅之，眞鍋　綾香，野元　裕
- Organizer
  第11回　分子寄生虫・マラリア研究フォーラム
- Place of Presentation
  長崎大学
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] Wheat-germ cell free system can be an expeditious platform for biochemical analysis of glycosyltransferases2012
- Author(s)
  中西雅之
- Organizer
  第10回無細胞科学松山国際シンポジウム
- Place of Presentation
  松山全日空ホテル
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] β3糖転移酵素ファミリーに属するアフリカトリパノソーマ原虫酵素の機能解析2012
- Author(s)
  中西雅之,白石喬寛,野元裕
- Organizer
  第10回分子寄生虫・マラリアフォーラム
- Place of Presentation
  群馬
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] β3糖転移酵素ファミリーに属するアフリカトリパノソーマ原虫酵素の機能解析2012
- Author(s)
  中西雅之
- Organizer
  第72回日本寄生虫学会東日本支部会・第10回分子寄生虫・マラリア研究フォーラム合同大会
- Place of Presentation
  群馬大学医学部
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] アフリカトリパノソーマ原虫においてN-結合型複合糖鎖の合成に関与する糖転移酵素2011
- Author(s)
  中西雅之,野元裕
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] Deletion of a putative glycosyltransferase gene from chromosome 8 in Trypanosoma brucei reduces the size of N-glycans2011
- Author(s)
  Masayuki Nakanishi, Hiroshi Nomoto
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] proNGFとソーチリンによる細胞死を制御する物質の探索2010
- Author(s)
  日野真美、中西雅之、中矢結子、古川美子、野元裕
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20659239
[Presentation] Disruption and characterisation of glycosyltransferases encoded by genes on chromosome 8 of Trypanosoma brucei2010
- Author(s)
  中西雅之, 有岡宏哲, 井上弥希, 野元裕
- Organizer
  The XIIth International Congress of Parasitology 2010
- Place of Presentation
  メルボルン
- Year and Date
  2010-08-18
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] Disruption and characterisation of glycosyltransferases encoded by genes on chromosome 8 of Trypanosoma brucei2010
- Author(s)
  Masayuki Nakanishi, Hiroaki Arioka, Miki Inoue, Hiroshi Nomoto
- Organizer
  The XIIth International Congress of Parasitology 2010
- Place of Presentation
  オーストラリア
- Year and Date
  2010-08-18
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] Deletion of a glycosyltransferase gene, TbGT8, in Trypanosoma brucei affects the size of a 57 kDa protein in the mammalian stage2010
- Author(s)
  中西雅之,井上弥希,好井啓輔,野元裕
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590385
[Presentation] ドリコール上でのN-結合糖鎖前駆体の形成はTrypanosoma bruceiの生存に必須である
- Author(s)
  中西　雅之，野元　裕
- Organizer
  第84回　日本寄生虫学会大会
- Place of Presentation
  杏林大学
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25460522
[Presentation] Characterization of a glycosyltransferase involved in priming of the synthesis of complex-type N-linked glycans in Trypanosoma brucei
- Author(s)
  Masayuki Nakanishi, Ayaka Manabe, Hiroshi Nomoto
- Organizer
  13th International Congress of Parasitology
- Place of Presentation
  Mexico city
- Year and Date
  2014-08-10 – 2014-08-15
- Data Source
  KAKENHI-PROJECT-25460522

1. KITADE Yukio (20137061)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 田中信忠 (00286866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. UENO Yoshihito (20250467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 古川美子 (20219108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 中島光業 (70311404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 畑晶之 (50241972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岩村樹憲 (70184900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 波多江典之 (30449912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 加来鉄平 (20435077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKANISHI Masayuki 中西 雅之

中西 雅之 ナカニシ マサユキ

Research Projects

Research Products

Co-Researchers

Elucidation of a synthetic pathway for complex-type N-linked glycans in Trypanosoma bruceiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function and biosynthetic machinary of complex N-glycans expressing in Trypanosoma bruceiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脊髄損傷修復への応用をめざした新たな神経保護薬の創生

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マラリア原虫における非メバロン酸経路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

X線結晶構造解析を基盤とする熱帯熱マラリア原虫酵素の特異的阻害薬の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new generation of 2-5A-antisense and its property for the regulation of gene expression.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マラリア原虫由来S-アデノシルホモシステイン加水分解酵素の挿入配列の機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

STUDY ON DRUG-DESIGN AND SYNTHESIS OF NOVEL 2-5A-ANTISENSE CHIMERAS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

組換えSAHaseを標的とするマラリア治療薬の開発研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

抗ウィルスマシーナリー-2-5Aシステム-の構造生物学Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

2-5Aを擬態する抗ウィルス性ペプチドの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SAHaseの触媒機能探索と医薬品開発を指向するリード化合物の分子設計

Principal Investigator

Project Period (FY)

Research Category

Research Institution

STUDY ON CATALYTIC REACTION MECHANISM OF ADENOSYLHOMOCYSTEINE HYDRLASE AND SYNTHESIS OF THEIR MECANISM -BASED INHIBITORS

Principal Investigator

Project Period (FY)

Research Category

Research Field

NAKANISHI Masayuki 中西雅之

中西雅之ナカニシマサユキ