TSUJIMOTO Masafumi 辻本雅文

Researcher Number	00281668
Affiliation (based on the past Project Information) *help	2012 – 2016: 帝京平成大学, 薬学部, 教授 2004 – 2008: RIKEN, Cellular Biochemistry Laboratory, Laboratory Head, 辻本細胞生化学研究室, 主任研究員 2003: 独立行政法人理化学研究所, 細胞生化学研究室, 主任研究員 2002: RIKEN, Chief Scientist, 理化学研究所・細胞生化学研究室, 主任研究員 2001: 理化学研究所, 細胞生化学, 主任研究員 1999 – 2001: 理化学研究所, 細胞生化学研究室, 主任研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Biological pharmacy / Biological pharmacy Except Principal Investigator Biological pharmacy / Environmental and hygienic pharmacy / Obstetrics and gynecology / Molecular biology / Biological Sciences
Keywords	Principal Investigator 胎盤性ロイシンアミノペプチダーゼ / 脂肪細胞由来ロイシンアミノペプチダーゼ / アミノペプチダーゼ / 小胞体アミノペプチダーゼ / オキシトシナーゼサブファミリー / 白血球由来アルギニンアミノペプチダーゼ / バソプレシン / ERAP1 / ノックアウトマウス / 一酸化窒素 … More / 高血圧症 / 大量発現系 / アミノペプチダーゼA / 高架式十字迷路試験 / 強制水泳試験 / 尾懸垂試験 / ERAP1-/-マウス / 遺伝子欠損マウス / セロトニン / ER Retention Mechanism / MHC Class I Antigenic Peptides / NRK52E Cells / Leukocyte-derived Arginine Aminopeptidase / Adipocyte-derived Leucine Aminopeptidase / Placental Leucine Aminopeptidase / Oxytocinase Subfamily / Aminopeptidase / 小胞体貯留機構 / 腎尿細管 / 本態性高血圧症 / 小胞体貯留 / 抗原ペプチド / 小胞体内貯留 / MHCクラスI抗原ペプチド / 腎尿細管細胞 / 白血球由来アルギニンアミノペブチダーゼ / cDNA CLONING / BLOOD PRESSURE / VASOPRESSIN / BIOACTIVE PEPTIDE / ADIPOCYTE-DERIVED LEUCINE AMINBOPEPTIDASE / PLACENTAL LEUCINE AMINOPEPTIDASE / OXYTOCINASE / AMINOPEPTIDASE / 胎盤性ロイシンアミノペプチターゼ / 金属酵素 / タンパク質結晶化 / CHO細胞 / ペプチドホルモン / 神経細胞 / プロモーター領域 / 尿細管 / 遺伝子クローニング / 血圧調節 / 生理活性ペプチド / オキシトシナーゼ / カルモジュリン / MyD88 / Toll-様受容体 / アルギニン / M1アミノペプチダーゼ / NO産生 / LPS / インターフェロン / マクロファージ / アンギオテンシンIV / 立体構造解析 / 白血球由来アルギニンアミノペップチダーゼ / リーベリン / 一塩基多型 / 基質特異性 / 阻害剤 / インターフェロン-γ / HuVEC / 血管新生 … More Except Principal Investigator アフリカツメガエル / 翻訳調節 / mRNA / mRNP / Y-ボックス蛋白質 / 貪食 / ERAP1 / インターフェロンーγ / エキソソーム / 細胞間情報伝達 / 一酸化窒素 / Toll like receptor 4 / LPS / 唾液 / DPP IV / マクロファージ / exosome / P-body / Xenonus / ribonucleonrotein narticle / translational control / P-ボディ / リボ蛋白質複合体 / Translational control / Y-box protein / RNA結合蛋白質 / mRNAの局在 / Yボックス蛋白質 / transgenic animal / gene targeting / aminopeptidase / preterm delivery / placenta / recombinant protein / molecular biology / oxytocinase / インヒビター / ゲノムクローニング / リコンビナントP-LAP / ペプチドホルモン / EIA / ノックアウトマウス / トランスジェニックマウス / アミノペプチダーゼ / 遺伝子動物 / 免疫染色 / 転写 / オキシトシン / 遺伝子組み換え動物 / 遺伝子組み換え / アミノペプチダーセ / 早産 / 胎盤 / 組み換え蛋白 / 分子生物学 / オキシトシナーゼ / TAF- I / Xenopus / adenovirus / histpne chaperon / histone / chromatin / TAF-I / アデノウイルス / クロマチン / 転写因子 / 破骨細胞 / p38MAPK / シグナル伝達 / 造血幹細胞 Less

Role of ERAP1 in the pathogenesis of mental disordersPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO MASAFUMI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Pathophysiological roles of M1 aminopeptidasesPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Molecular mechanism and regulation of immune activation cascade by aminopeptidase contained exosome.
- Principal Investigator
  
  OGAWA Yuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Teikyo Heisei University
Role of aminopeptidases in atherosclerosisPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Teikyo Heisei University
Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of AminopeptidasesPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Control of translation and mRNA degradation by mPnP components
- Principal Investigator
  
  MATSUMOTO Ken
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
血管新生の制御を目指した新たな標的分子の探索Principal Investigator
- Principal Investigator
  
  辻本雅文
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
The oxytocinase subfamily of M1 aminopeptidasesPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  RIKEN
Formation of mRNPs and mRNA localization
- Principal Investigator
  
  MATSUMOTO Ken
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  RIKEN
P38MAPキナーゼを介した造血幹細胞の時系列分化の分子メカニズムの解明
- Principal Investigator
  
  松本征仁
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Saitama Medical University
アフリカツメガエル卵母細胞における翻訳調節機構
- Principal Investigator
  
  MATSUMOTO Ken
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
Physiological roles of placental leucine aminopeptidase/oxytocinase and its clinical application using molecular biological technique.
- Principal Investigator
  
  MIZUTANI Shigehiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nagoya University
STRUCTURE AND FUNCTION OF NOVEL AMINOPEPTIDASES BELONGING TO OXYTOCINASE SUB-FAMILYPrincipal Investigator
- Principal Investigator
  
  TSUJIMOTO Masafumi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Riken
Molecular mechanisms of chromatin decondensation mediated by novel histone chaperones
- Principal Investigator
  
  MATSUMOTO Ken
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  RIKEN

All 2016 2015 2014 2013 2012 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Aminopeptidase Q/Laeverin in Handbook of proteolytic enzymes third edition2013
- Author(s)
  Akira Hattori, Masato Maruyama Hiroshi Fujiwara Masafumi Tsujimoto
- Total Pages
  4104
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24659153
[Journal Article] Next-Generation Sequencing of Protein-Coding and Long Non-protein-Coding RNAs in Two Types of Exosomes Derived from Human Whole Saliva2016
- Author(s)
  Yuko Ogawa, Masafumi Tsujimoto, Ryohei Yanoshita
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 9 Pages: 1496-1507
- DOI
  10.1248/bpb.b16-00297
- NAID
  130005415106
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460172
[Journal Article] Substrate-dependentnitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015
- Author(s)
  Goto, Y., Ogawa, K., Nakamura, T.J., Hattori, A. and Tsujimoto, M.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 157 Pages: 439-449
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K15088
[Journal Article] Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015
- Author(s)
  Yoshikuni Goto, Kenji Ogawa, Takahiro J Nakamura, Akira Hattori, Masafumi Tsujimoto
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 157 Issue: 6 Pages: 439-49
- DOI
  10.1093/jb/mvv001
- NAID
  40020489236
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24659153, KAKENHI-PROJECT-26860160, KAKENHI-PROJECT-25293083
[Journal Article] Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B.2015
- Author(s)
  Ohnishi A., Watanabe J., Ogawa Y., Goto Y., Hattori A., Tsujimoto M.
- Journal Title
  
  Biochemistry
  
  Volume: 54(39) Issue: 39 Pages: 6062-70
- DOI
  10.1021/acs.biochem.5b00964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460172, KAKENHI-PROJECT-25293083
[Journal Article] TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages2014
- Author(s)
  Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 9 Pages: 4443-4452
- DOI
  10.4049/jimmunol.1300935
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24659153, KAKENHI-PROJECT-24790083, KAKENHI-PROJECT-24790238, KAKENHI-PROJECT-25293083, KAKENHI-PROJECT-26860160
[Journal Article] Role of glutamine-169 in the substrate recognition of human aminopeptidase B2014
- Author(s)
  Ogawa Y, Ohnishi A, Goto Y, Sakuma Y, Watanabe J, Hattori A, Tsujimoto M
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1840 Issue: 6 Pages: 1872-1881
- DOI
  10.1016/j.bbagen.2014.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24790083, KAKENHI-PROJECT-25293083, KAKENHI-PROJECT-25460172
[Journal Article] Endoplasmic reticulum aminopeptidases : biochemistry, physiology and pathology2013
- Author(s)
  Hattori A, & Tsujimoto M
- Journal Title
  
  J Biochem
  
  Volume: 154 Issue: 3 Pages: 219-228
- DOI
  10.1093/jb/mvt066
- NAID
  40019769818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24659153, KAKENHI-PROJECT-25293083
[Journal Article] Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum minopeptidase 12012
- Author(s)
  Akira Hattori, Yoshikuni Goto Masafumi Tsujimoto
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35 Pages: 601-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659153
[Journal Article] Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic reticulum aminopeptidase-12008
- Author(s)
  Goto, Y., Tanji, H., Hattori, A. and Tsujimoto, M.
- Journal Title
  
  Biochem. J. 416
  
  Pages: 109-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Biochemical and enzymatic properties of M1 family of aminopeptidases involved in the regulation of blood pressure2008
- Author(s)
  Masafumi Tsujimoto
- Journal Title
  
  Heart Failure Reviews 13
  
  Pages: 285-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan2008
- Author(s)
  Ishii, M., Hattori, A., Numaguchi, Y., Tsujimoto, M., Ishiura, S., Kobayashi, H., Murohara, T., Wright, J.W. and Mizutani, S.
- Journal Title
  
  Horm Metab Res. 40
  
  Pages: 887-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure2008
- Author(s)
  Masafumi Tsujimoto
- Journal Title
  
  Heart Failure Reviews (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Biochemical and enzymatic properties of M1 family of aminopeptidases involved in the regulation of blood pressure2008
- Author(s)
  Tsujimoto, M., Goto, Y., Maruyama, M. and Hattori, A.
- Journal Title
  
  Heart Fail. Rev. 13
  
  Pages: 285-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Asparatic acid-221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A2007
- Author(s)
  Goto, Y., Hattori, A., Mizutani, S, and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 37074-37081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Essential role of placental leucine aminopeptidase in gynecologic malignancy2007
- Author(s)
  Mizutani, S., Shibata, K., Kikkawa, F., Hattori, A., Tsujimoto, M., Ishii, M. and Kobayashi, H.
- Journal Title
  
  Expert Opin. Ther. Targets 11
  
  Pages: 453-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] New insights into the importance of aminopeptidase A in hypertension2007
- Author(s)
  Mizutani, S., Ishii, M., Hattori, A., Nomura, S., Numaguchi, Y., Tsujimoto, M., Kobayashi, H., Murohara, T. and Wright, J.S.
- Journal Title
  
  Heart Fail. Rev. 13
  
  Pages: 273-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Laeverin/aminopeptidase Q, a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopsptidases2007
- Author(s)
  Maruyama, M., Hattori, A., Goto, Y., Ueda, M., Maeda, M., Fujiwara, H. and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 20088-20096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] M1アミノペプチダーゼファミリーの新たな生理機能2006
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  日本血栓止血学会誌 17
  
  Pages: 20-28
- NAID
  10021258236
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-12006
- Author(s)
  Goto, Y., Hattori, A., Ishii, Y. and Tsujimoto, M.
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1833-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Physiological roles of M1 aminopeptidase family2006
- Author(s)
  Hattori A., Tsujimoto M.
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis 17
  
  Pages: 20-28
- NAID
  10021258236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] M1アミノペプチダーゼファミリーの新たな生理機能2006
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  日本血栓止血学会誌 17
  
  Pages: 20-28
- NAID
  10021258236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] Enzymatic properties of human aminopeptidase A; regulation of its enzymatic activity by calcium and angiotensin IV2006
- Author(s)
  Goto, Y., Hattori, A., Ishii, Y., Mizutani, S. and Tsujimoto, M.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 23503-23513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390031
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2005
- Author(s)
  Tsujimoto M., Hattori A.
- Journal Title
  
  Biochimica et Biophysica Acta 1751
  
  Pages: 9-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2005
- Author(s)
  Tsujimoto M., Hattori A.
- Journal Title
  
  Biochiemica et Biophysica Acta (in press)
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] 小胞体アミノペプチダーゼの発見とそのMHCクラスI抗原ペプチドプロセシングにおける役割2005
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  化学と生物 43巻11号
  
  Pages: 698-704
- Data Source
  KAKENHI-PROJECT-16659025
[Journal Article] 小胞体アミノペプチダーゼの発見とMHCクラス-I抗原ペプチドプロセシングにおける役割2005
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  化学と生物 43
  
  Pages: 739-745
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] Endoplasmic reticulum aminopeptidases2005
- Author(s)
  Hattori A., Tsujimoto M.
- Journal Title
  
  Kagaku To Seibutsu 43
  
  Pages: 739-745
- NAID
  130003634488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2005
- Author(s)
  Tsujimoto M., Hattori A.
- Journal Title
  
  Biochiemica et Biophysica Acta (in press)
- Data Source
  KAKENHI-PROJECT-16659025
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2005
- Author(s)
  Tsujimoto M., Hattori A.
- Journal Title
  
  Biochim.Biophys.Acta 1751
  
  Pages: 9-18
- Data Source
  KAKENHI-PROJECT-16659025
[Journal Article] 小胞体アミノペプチダーゼの発見とそのMHCクラスI抗原ペプチドプロセシングにおける役割2005
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  化学と生物 43巻11号
  
  Pages: 698-704
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2005
- Author(s)
  Tsujimoto M., Hattori A.
- Journal Title
  
  Biochim.Biophys.Acta 1751
  
  Pages: 9-18
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] Processing of antigenic peptidases by aminopeptidases2004
- Author(s)
  Hattori A., Tsujimoto M.
- Journal Title
  
  Biological and Pharmaceutical.Bulletin 27
  
  Pages: 777-780
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] Processing of antigenic peptidases by aminopeptidases2004
- Author(s)
  Hattori A., Tsujimoto M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin 27
  
  Pages: 777-780
- Data Source
  KAKENHI-PROJECT-16659025
[Journal Article] Processing of antigenic peptidases by aminopeptidases2004
- Author(s)
  Hattori A., Tsujimoto M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin 27
  
  Pages: 777-780
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] オキシトシナーゼサブファミリー-M1アミノペプチダーゼの新しいサブファミリーの同定とその生理機能2003
- Author(s)
  服部明, 辻本雅文
- Journal Title
  
  生化学 75
  
  Pages: 1225-1230
- NAID
  50000316590
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Journal Article] The oxytocinase subfamily of M1 aminopeptidases2003
- Author(s)
  Hattori A., Tsujimoto M
- Journal Title
  
  SEIKAGAKU 70
  
  Pages: 1225-1230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390032
[Presentation] 小胞体アミノペプチダーゼはエンドトキシンショック時に惹起される一酸化窒素合成を亢進する2016
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 服部明, 辻本雅文
- Organizer
  第89回　日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K15088
[Presentation] 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する2015
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 青嶋瑞樹, 荒俣晃貴, 高田慧, 町田綾乃, 吉野僚太, 服部明, 辻本雅文
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する2015
- Author(s)
  後藤芳邦, 小川健司, 中村孝博, 青嶋瑞樹, 荒俣晃貴, 高田慧, 町田綾乃, 吉野僚太, 服部明, 辻本雅文
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15088
[Presentation] 分泌型小胞体アミノペプチダーゼ１によるArg産生を介したマクロファージのNO産生亢進2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] アミノペプチダーゼBの基質特異性におけるGln169の役割2013
- Author(s)
  小川裕子、大西敦、後藤芳邦、辻本雅文
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] 分泌型小胞体アミノペプチダーゼ１によるArg産生を介したマクロファージのNO産生亢進2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌2013
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部　明、辻本雅文
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] 小胞体アミノペプチダーゼの分泌を介したマクロファージのNO産生亢進2012
- Author(s)
  後藤芳邦, 小川健司, 服部明, 辻本雅文
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659153
[Presentation] 小胞体アミノペプチダーゼの酵素活性と機能制御機構2009
- Author(s)
  辻本雅文
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 小胞体アミノペプチダーゼの基質認識機構2009
- Author(s)
  後藤芳邦、丹治弘江、服部明、辻本雅文
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] カルシウムイオンによるアミノペプチダーゼ-A活性制御機構の解明2008
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 膜結合型M1アミノペプチダーゼの酵素活性とその制御2008
- Author(s)
  辻本雅文
- Organizer
  第13回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 点変異導入によるヒトlaeverinのHis379残基の機能解明2008
- Author(s)
  有坂尚美、丸山正人、服部明、辻本雅文
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会 (BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 膜結合型M1アミノペプチダーゼの酵素活性とその制御2008
- Author(s)
  辻本雅文
- Organizer
  第13回病態と治療におけるプロテアーゼとインヒビター学会
- Place of Presentation
  吹田/大阪
- Year and Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒト脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である2008
- Author(s)
  後藤芳邦、丹治弘江、服部明、辻本雅文
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会 (BMB2008)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Laeverin/aminopeptidase Q: a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases2007
- Author(s)
  Maruyama, M., Hattori, A, Goto, Y. Ueda, M. Maeda, M. Fujiwara, H. and Tsujimoto, M.
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Patras, Greece
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒトアミノペプチダーゼAのAsp221残基はカルシウムによる活性制御に必須である2007
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第30回日本分子生物学会年会/第80回日本生化学会大会 (BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 新規アミノペプチダーゼLaeverinの酵素学的性状の解析2007
- Author(s)
  丸山正人、服部明、後藤芳邦、藤原浩、辻本雅文
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Asp-221 plays an essential role in the calcium-dependent regulatory mechanism of human aminopeptidase A2007
- Author(s)
  Goto, Y., Hattori, A. Mizutani, S. and Tsujimoto, M.
- Organizer
  5th General Meeting of the International Proteolysis Society
- Place of Presentation
  Patras, Greece
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] アミノペプチダーゼAのAsp-221残基はカルシウムとの相互作用に必須である2007
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第12回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] アミノペプチダーゼAの酵素活性はCa^<2+>とAngIVによって制御される2006
- Author(s)
  後藤芳邦、服部明、辻本雅文
- Organizer
  第50回日本薬学会関東支部大会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Characterization of recombinant human aminopeptidase A expressed in a baculovirus system2006
- Author(s)
  Goto, Y., Hattori, M., Ishii, Y., Mizutani, S. and Tsujimoto, M.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] 神経細胞における胎盤性ロイシンアミノペプチダーゼの細胞膜移行誘導メカニズムの解明2006
- Author(s)
  丸山正人、服部明、辻本雅文
- Organizer
  第11回病態と治療におけるプロテアーゼとインヒビター研究会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] Identification of SDF2-L1 as a binding protein to A-LAP/ERAP1 in the ER2006
- Author(s)
  Hattori, A. and Tsujimoto, M.
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-18390031
[Presentation] ヒト唾液エキソソームによるマクロファージの活性化
- Author(s)
  小川（池本）裕子, 粂田奈宝子, 後藤芳邦, 池本守, 辻本雅文, 矢ノ下良平
- Organizer
  第87回日本生化学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25460172
[Presentation] 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部明、辻本雅文
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293083
[Presentation] 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下
- Author(s)
  後藤芳邦、小川健司、中村孝博、服部明、辻本雅文
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24659153

1. HATTORI Akira (50300893)

# of Collaborated Projects: 7 results

# of Collaborated Products: 56 results
2. GOTO Yoshikuni (90455345)

# of Collaborated Projects: 5 results

# of Collaborated Products: 32 results
3. MATSUMOTO Ken (60222311)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. OGAWA Yuko (30267330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. MARUYAMA Masato (00399445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. TAKASU Kiyosei (10302168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OGAWA Kenji (50251418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. NOMURA Yosihiro (10228372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUMOTO Hideo (00312257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGATA Kyosuke (40180492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIZUTANI Shigehiko (00159162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NOMURA Seiji (20242860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MASUDA Shinako (30342851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TANIOKA Toshihiro (80360585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YANOSHITA Ryohei (90267336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 松本征仁 (90321819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 須藤龍彦 (30260227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 久武幸司 (70271236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUJIMOTO Masafumi 辻本 雅文

Research Projects

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Co-Researchers

Role of ERAP1 in the pathogenesis of mental disordersPrincipal Investigator

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Pathophysiological roles of M1 aminopeptidasesPrincipal Investigator

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Molecular mechanism and regulation of immune activation cascade by aminopeptidase contained exosome.

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Role of aminopeptidases in atherosclerosisPrincipal Investigator

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Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of AminopeptidasesPrincipal Investigator

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Control of translation and mRNA degradation by mPnP components

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血管新生の制御を目指した新たな標的分子の探索Principal Investigator

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The oxytocinase subfamily of M1 aminopeptidasesPrincipal Investigator

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Formation of mRNPs and mRNA localization

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P38MAPキナーゼを介した造血幹細胞の時系列分化の分子メカニズムの解明

Principal Investigator

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Review Section

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アフリカツメガエル卵母細胞における翻訳調節機構

Principal Investigator

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Physiological roles of placental leucine aminopeptidase/oxytocinase and its clinical application using molecular biological technique.

Principal Investigator

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STRUCTURE AND FUNCTION OF NOVEL AMINOPEPTIDASES BELONGING TO OXYTOCINASE SUB-FAMILYPrincipal Investigator

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TSUJIMOTO Masafumi 辻本雅文