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HIROTA Kiichi  広田 喜一

Researcher Number 00283606
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-1110-0827
Affiliation (based on the past Project Information) *help 2022 – 2023: 関西医科大学, 医学部, 研究員
2016 – 2021: 関西医科大学, 医学部, 教授
2017: 関西医科大学, 医学部生命科学, 教授
2013 – 2015: 関西医科大学, 医学部, 准教授
2012: 京都大学, 医学(系)研究科(研究院), 准教授 … More
2012: 京都大学, 医学(系)研究科(研究院), 講師
2011 – 2012: 京都大学, 医学研究科, 准教授
2005 – 2011: Kyoto University, Department of Anesthesia, Lecturer, 医学研究科, 講師
2008: Kyoto University, 大学院・医学研究科, 講師
2008: 京都大学, 大学院医学研究科, 講師
2007 – 2008: 京都大学, 医学系研究科, 講師
2005 – 2006: 京都大学, 大学院医学研究科, 講師
2005: Kyoto University, Graduate School of Medicine, Department of Anethesia, Associated Professor, 医学研究所麻酔科, 講師
2005: Kyoto University, Graduate School of Medicine, Department of Anesthesia, Associate Professor, 医学研究科麻酔科, 講師
2004: 財団法人田附興風会, 医学研究所・第3研究部, 主任研究員
2003: 産業技術総合研究所HSSセンター, 主任研究員
2003: 財団法人田附興風会, 医学研究所・第3研究部, 研究員
1997 – 1999: 京都大学, 医学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology / Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Biological Sciences
Except Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology / Basic Section 55050:Anesthesiology-related / General surgery / Thoracic surgery … More / Kidney internal medicine / Anesthesiology/Resuscitation studies / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Experimental pathology / Laboratory medicine / Tumor biology Less
Keywords
Principal Investigator
HIF-1 / 低酸素 / 酸素代謝 / 低酸素誘導性因子1 / 麻酔薬 / 転写因子 / シグナル伝達 / 低酸素誘導性因子 / 分子生物学 / ストレス … More / 細胞 / 遺伝子 / 低酸素応答 / エピゲノム / 抗体産生 / B細胞 / エピゲノム変化 / 代謝リプログラミング / HIF / 免疫 / 長期予後 / 麻酔 / 細胞外酸性化速度 / 酸素消費量 / ミトコンドリアサイブリッド細胞 / 電子伝達系 / プロポフォール注入症候群 / 細胞死 / サイブリッド / ミトコンドリア / プロポフォール / inflammation / hypoxia sensor / differentiation / macrophage / hypoxia / 分化 / マクロファージ / 炎症 / NAPK / Ap-1 / transcription factor / glutaredoxin / thioredoxin / redox regulation / cytokinemin / MAPK / AP-1 / グルタレドキシン / チオレドキシン / レドック制御 / 高サイトカイン血症 / 酸素担体 / 周術期低酸素 / マイクロバブル / 酸素 / 窒息 / 脂質二重膜酸素封入微小バブル / 低酸素血症 / 解糖 / 保護 / リプログラミング / 代謝 / 腎臓 / プレコンディショニング / 臓器保護 / 麻酔科学 / 周術期 / 細胞生物学 / 薬理学 / HIT-1 / 発現制御 / 細胞・組織 / 周術期管理学 / ガン抑制遺伝子 / エネルギー代謝 / 水酸化酸素 / 血管新生 / ガン … More
Except Principal Investigator
低酸素誘導性因子1 / HIF-1 / 低酸素 / 炎症 / Aminopeptidase N / thioredoxin / CD13 / レドックス / チオレドキシン / タバコ / ストレス / 麻酔薬 / Human Monoclonal Antibody / ヒト型モノクローナル抗体 / 低酸素誘導性因子 / redox / 酸素代謝 / 肺障害 / 肺胞上皮 / 代謝 / シグナル伝達 / PAI-1 / TNF-α / ミトコンドリア / がん / hypoxia / MCP-1 / ADCC効果 / 血管新生 / 転移抑制 / CD151 / PETA3 / CD82 / KAI1 / CD9 / MRP-1 / AAH / TM4SF / 周術期 / oxidative stress / ELISA / 酸化ストレス / 細胞間バリア / 自然免疫 / マイクログリア / タイトジャンクション / 遺伝子発現 / 水チャネル / 周術期管理学 / 脂肪酸結合蛋白 / PPAR / 遺伝子 / 低酸素血症 / 呼吸不全 / 人工呼吸 / 動物実験 / 腹膜 / 肺外呼吸 / メタゲノム / 血液 / DNAメタバーコーディング / 感染 / マイクロバイオーム / ナノポアシークエンシング / 真菌 / 細菌 / 肺バリア / 肺血管内皮 / タバコ抽出液 / 喫煙 / マクロファージ / CD39 / CD73 / 細胞間バリア機能 / interferonβ-1a / 急性呼吸窮迫症候群 / RNA-Seq法 / 三次元スフェア培養 / がん幹細胞 / 神経膠腫 / 周術期医学 / 硫化水素 / 蛋白質 / 細胞・組織 / 感染症 / 気道 / 活性酸素 / 慢性閉塞性肺疾患 / IL-1 / マイクリグリア / 炎症性サイトカイン / IL-1b / スフェロイド / 転移 / RNA-Seq / CTOS / 悪性度 / がん細胞 / 急性肺傷害 / TXNIP / 急性肺障害 / 敗血症 / 酸素環境 / Metastasis Inhibition / Angiogenesis / Aminomotidase N / アミノペプチダーゼN / fatty acid-binding proteins / peroxisome proliferator-ativiated receptors / human proximal renal tubular cells / renal fibrosis / 脂質親和性転写因子 / lipid-binding proteins / proximal renal tubular cells / 抗炎症作用 / 脂質転送蛋白 / ペルオキシゾーム増殖薬反応性受容体 / ヒト近位尿細管上皮細胞 / 進行性腎障害 / KM mouse / Aminopeputidase N / Aminopaptidase N / KMマウス / angiogenesis / metastasis inhibition / AminopeptidaseN / VEGF-A / MRP1 / 下位遺伝子 / gene expression / stress / perioperative period / hypoxia-inducible factor / 亜硝酸製剤 / 一酸化窒素 / 低酸素遺伝子応答 / オピオイド / 血管拡張薬 / 局所麻酔薬 / 静脈麻酔薬 / 低酸素誘導性遺伝子応答 / 発現制御 / 生体分子 / metabolic syndrome / vitamin D / Reye syndrome / cancer / aging / thioredoxin binding protein 2 / チオレドキシン結合タンパク質 / 遺伝子改変マウス / 細胞増殖 / シオレドキシン結合タンパク質 / 絶食 / 高脂血症 / 癌抑制 / 糖脂質代謝 / メタボリックシンドローム / ビタミンD / ライ症候群 / 癌 / 老化 / レドツクス / TBP-2 / cellular signal transduction / cytokine / glutaredoxin / MAPK / ストレス反応 / レドックス制御 / 生体応答 / 細胞内シグナル / サイトカイン / グルタレドキシン / transgenic mouse / ADF / トランスジェニックマウス / 接着分子 / 周術期管理 / エンドサイトーシス / デオコシグルコース / アポプトーシス / Caveolin / Bak / Mcl1 / 受容体型チロシンキナーゼ / コレステロール / 抗がん剤 / インスリン / 膵臓がん / コレシテロール / アポトーシス / beta-cyclodextrin / AKT / ABT-263 / デオキシグルコース / 腎癌 / 微小環境 / 脊髄 / 慢性疼痛 / 神経因性疼痛 / 肺胞炎症 / 肺水腫 / 無気肺 / 低酸素誘導因子 / ガレート / ラット / 脳虚血 / 蘇生学 / 低酸素誘導性遺伝子 / 臓器保護 / 転写因子 / 細胞 / VEGF / ハイドロコルチゾン / ミネラロコルチコイド受容体 / 脂肪酸結合蛋白(FABP) / 内皮細胞増殖因子(VEGF) / プラスミノーゲンアクチベーターインヒビター-1(PAI-1) / ピオグリタゾン / デキサメサゾン / ペルオキシゾーム増殖薬活性化受容体(PPAR) / グルココルチコイド受容体 / TGF-β / FABP / GR / 腎線維化 / 尿細管上皮細胞 / 腎臓学 / 麻酔 / real time PCR / 培養細胞 / 時計遺伝子 / 概日リズム / 日内変動 / 体内時計 / 突然変異 / PCR / リアノジンレセプタ / 悪性高熱症 / 悪性症候群 Less
  • Research Projects

    (43 results)
  • Research Products

    (370 results)
  • Co-Researchers

    (49 People)
  •  ナノポアシークエンサーによる血中マイクロバイオーム解析に基づく敗血症診断技術開発

    • Principal Investigator
      松尾 禎之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kansai Medical University
  •  腹膜を利用した肺外人工呼吸の研究

    • Principal Investigator
      村田 宮彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Tokai University
  •  Molecular biology of the mechanism of tobacco-induced reduction of lung barrier function based on HIF-1 activity analysis

    • Principal Investigator
      NISHI Kenichiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kansai Medical University
  •  Elucidation of the molecular basis of anesthesia-induced alteration of immune response through regulation of oxygen homeostasisPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kansai Medical University
  •  Mechanisms and implications of metabolic reprogramming of immune cells in the perioperative inflammatory response

    • Principal Investigator
      MATSUO Yoshiyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kansai Medical University
  •  Investigation of the effects of anesthetics on cancer tissue phenotype and gene expression using glioma stem cells

    • Principal Investigator
      IWAI Teppei
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Kansai Medical University
  •  The crosstalk between hypoxic reaction system and IFNbeta-1a signal at the control of vascular endothelial barrier function

    • Principal Investigator
      Adachi Takehiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      The Tazuke Kofukai
  •  Investigation of involvement of hypoxia-inducible factor 1 on cigarette smoke-induced airway and lung pathological events

    • Principal Investigator
      NISHI Kenichiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  Development of redox-based therapeutics against inflammation

    • Principal Investigator
      MATSUO Yoshiyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  Investigation of the molecular mechanisms of propofol toxiciy by using mitochondria cybridsPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  The impact of sulfide on metabolic reprogramming during hypoxia

    • Principal Investigator
      Kai Shinichi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Anesthesiology
    • Research Institution
      Kyoto University
  •  The role of cellular redox system in inflammatory disorders of acute lung injury

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      The Tazuke Kofukai
  •  Investigation of effects of anesthetics on phenotype and gene expression of cancer cells with CTOS method

    • Principal Investigator
      IWAI Teppai
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  Development of oxygen gas-filled microparticles providing intravenous oxygen deeliveryPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  The molecular mechanism of 2deoxyglucose-ABT-263 induced apoptosis

    • Principal Investigator
      YAMAGUCHI Ryuji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Kansai Medical University
  •  Involvement of the transcription factor HIF-1 in the cell-to-cell adhesion system

    • Principal Investigator
      NISHI Kenichiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kansai Medical University
  •  Effect of anesthetics on sepsis-induced cerebral inflammatory cytokine upregulagtion

    • Principal Investigator
      Tanaka Tomoharu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Kyoto University
  •  The impact of HIF-1 activation on respiratory epithelium during hypoxic insults.

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      The Tazuke Kofukai
  •  An investigation on the role of HIF-1 in the regulation of microglia activity

    • Principal Investigator
      TAKABUCHI Satoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kansai Medical University
      Kyoto University
  •  Investigation for establishment for a novel intervention to protect kidney against hypoxic injury by inducing metabolic reprogramming by manipulating the transcription factor HIF-1 activityPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kansai Medical University
      Kyoto University
  •  Investigation of molecular machamism of periopearetive oxygen metabolism regulation by hypoxia-inducible factorsPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Toward the establishment of induced metabolic reprograming, a new strategy for organ protectionPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats

    • Principal Investigator
      KAWANO Yasunobu
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Nara Medical University
  •  Cell biological analysis of the effect of hypoxia-induced gene expressions on progression of pulmonary alveolar inflammation

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      公益財団法人田附興風会
      Tazuke Kofukai Medical Research Institute
  •  Analysis for anti-inflammatory and anti-fibrotic actions of lipid transfer proteins and lipid-activated transcription factors in the progressive renal injury

    • Principal Investigator
      KIMURA Hideki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      University of Fukui
  •  Investigation of effect of perioperatively used drugs to in vivo oxygen metabolism regulation mediated by hypoxia-induced factor

    • Principal Investigator
      TAKABUCHI Satoshi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Cellular and molecular biological analysis of hypoxia-inducible genetic responses in lung epithelial cells

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  細胞内低酸素センサーの人為的調節による臓器プレコンディショニング獲得への基礎研究Principal Investigator

    • Principal Investigator
      広田 喜一
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Investigation on the molecular mechanism of maintenance of oxygen homeostasis by hypoxia-inducible factor 1 systemPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Clinical appliance to patients with lung cancer by human monoclonal antibody recognized Aminopeptidase N.

    • Principal Investigator
      MASAYUKI Miyake
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  体内時計に麻酔あるいは全身性ストレスが与える影響の検討

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  Investigation on anti-inflammatory effects of lipid-binding proteins and lipophilic transcriptional factors in progression of renal injury.

    • Principal Investigator
      KIMURA Hideki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      University of Fukui
  •  Analysis of the function of TM4SF complex and its application of lung cancer therapy.

    • Principal Investigator
      MIYAKE Masayuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      The Tazuke Kofukai
  •  Analysis of the function of Aminopeptidase N and neutral and peptidase and application of its cancer therapy.

    • Principal Investigator
      TOKUHARA Takahiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The Tazuke Kofukai
  •  Analysis of human monoclonal antibody suppressing metastasis and the mechanism of metastasis.

    • Principal Investigator
      ISHIDA Hisao
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The Tazuke Kofukai
  •  Study on the regulatory role of hypoxia sensor or hypoxia-inducible factor 1 system in inflammationPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
      Tazuke Kofukai Medical Research Institute
  •  HIF-1システムががんの進展に果たす役割の探究Principal Investigator

    • Principal Investigator
      広田 喜一
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tazuke Kofukai Medical Research Institute
  •  The study on the regulation of cellular growth and aging process by thioredoxin binding protein

    • Principal Investigator
      YODOI Junji
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyoto University
  •  The effect of perioperatively used drugs on the HIF-1 activation and its downstream gene expressions.

    • Principal Investigator
      ADACHI Takehiko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      THE TAZUKE KOFUKAI
  •  A study on cellualr redox regulation in response to cytokine stresses

    • Principal Investigator
      YODOI Junji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      KYOTO UNIVERSITY
  •  悪性症候群患者におけるライアノジン受容体1の遺伝子突然変異の検索

    • Principal Investigator
      森 健次郎
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kyoto University
  •  Monitoring system of oxidative stress and therapeutic approach to oxidative stress-associated disorders by redox-regulating drugs

    • Principal Investigator
      YODOI Junji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      KYOTO UNIVERSITY
  •  Redox regulation of Cellular responses against cytokine stressPrincipal Investigator

    • Principal Investigator
      HIROTA Kiichi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      KYOTO UNIVERSITY

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 癌と臨床栄養2016

    • Author(s)
      広田 喜一
    • Publisher
      日本医事新報
    • Data Source
      KAKENHI-PROJECT-15K15577
  • [Book] Hypoxia and hypoxia-inducible factor in inflammation, in: S. Roy (Ed.), Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions2012

    • Author(s)
      K. Hirota
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Book] グルタミノリシス, in: 曽我 朋義, 江角浩安 (編), がんと代謝 (実験医学 増刊)2012

    • Author(s)
      広田 喜一
    • Publisher
      羊土社, 東京
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Book] 周術期の呼吸管理(低酸素性肺障害の分子生物学)2007

    • Author(s)
      広田喜一
    • Publisher
      克誠堂出版
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Book] 周術期の呼吸管理(低酸素性肺障害の分子生物学)2007

    • Author(s)
      広田喜一
    • Publisher
      克誠堂出版
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Book] Frontiers in lmmuno-gene Therapy2004

    • Author(s)
      Hattori.N., Miyake, M.
    • Total Pages
      16
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Book] Frontiers in Immuno-gene Therapy2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Total Pages
      16
    • Publisher
      Osamu Mazda
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Book] Frontiers in Immuno-gene Therapy2004

    • Author(s)
      Hattori, N, Miyake, M.
    • Total Pages
      16
    • Publisher
      Osamu Mazda
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Book] Frontiers in Immuno-gene Therapy2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Total Pages
      16
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Book] Frontiers in Immuno-gene Therapy2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Total Pages
      16
    • Publisher
      Research Signpost
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Book] Frontiers in Immuno-gene Therapy2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Total Pages
      16
    • Publisher
      Osamu Mazda
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Book] Hypoxia andhypoxia-inducible factor in inflammation. InCHRONIC INFLAMMATION : NUTRITIONAL & THERAPEUTIC INTERVENTIONS, S. Roy

    • Author(s)
      Hirota, K.
    • Publisher
      Taylor & Francis
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Using nanopore sequencing to identify fungi from clinical samples with high phylogenetic resolution2023

    • Author(s)
      Ohta Atsufumi、Nishi Kenichiro、Hirota Kiichi、Matsuo Yoshiyuki
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 9785-9785

    • DOI

      10.1038/s41598-023-37016-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09106
  • [Journal Article] Impact of neoadjuvant therapy on gut microbiome in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma2023

    • Author(s)
      Takaori Ayaka、Hashimoto Daisuke、Ikeura Tsukasa、Ito Takashi、Nakamaru Koh、Masuda Masataka、Nakayama Shinji、Yamaki So、Yamamoto Tomohisa、Fujimoto Kosuke、Matsuo Yoshiyuki、Akagawa Shohei、Ishida Mitsuaki、Yamaguchi Kiyoshi、Imoto Seiya、Hirota Kiichi、Uematsu Satoshi、Satoi Sohei、Sekimoto Mitsugu、Naganuma Makoto
    • Journal Title

      Pancreatology

      Volume: - Issue: 4 Pages: 367-376

    • DOI

      10.1016/j.pan.2023.04.001

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16032, KAKENHI-PROJECT-21H03538, KAKENHI-PROJECT-22K16057, KAKENHI-PROJECT-22K16329, KAKENHI-PROJECT-22K09106, KAKENHI-PROJECT-22H00477
  • [Journal Article] Inflammatory Cytokine-Induced HIF-1 Activation Promotes Epithelial?Mesenchymal Transition in Endometrial Epithelial Cells2023

    • Author(s)
      Hashimoto Yoshiko、Tsuzuki-Nakao Tomoko、Kida Naoko、Matsuo Yoshiyuki、Maruyama Tetsuo、Okada Hidetaka、Hirota Kiichi
    • Journal Title

      Biomedicines

      Volume: 11 Issue: 1 Pages: 210-210

    • DOI

      10.3390/biomedicines11010210

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-20H03826, KAKENHI-PROJECT-21K09480
  • [Journal Article] Efficacy of active hexose correlated compound on survival of patients with resectable/borderline resectable pancreatic cancer: a study protocol for a double-blind randomized phase II study2022

    • Author(s)
      Hashimoto Daisuke、Satoi Sohei、Ishikawa Hideki、Kodera Yasuhiro、Kamei Keiko、Hirano Satoshi、Fujii Tsutomu、Uemura Kenichiro、Tsuchida Akihiko、Yamada Suguru、Yamamoto Tomohisa、Hirota Kiichi、Sekimoto Mitsugu
    • Journal Title

      Trials

      Volume: 23 Issue: 1 Pages: 135-135

    • DOI

      10.1186/s13063-021-05934-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-20K11545
  • [Journal Article] Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro.2022

    • Author(s)
      Shoji T, Hayashi M, Sumi C, Kusunoki M, Uba T, Matsuo Y, Hirota K.
    • Journal Title

      Medicina

      Volume: 58(11) Issue: 11 Pages: 1614-1614

    • DOI

      10.3390/medicina58111614

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09166, KAKENHI-PROJECT-21K09191, KAKENHI-PROJECT-22K07924, KAKENHI-PROJECT-22K09220, KAKENHI-PROJECT-22K09245, KAKENHI-PROJECT-22K09295, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-21H03047, KAKENHI-PROJECT-20K09337, KAKENHI-PROJECT-20K09400
  • [Journal Article] Rapid detection of single nucleotide polymorphisms using the MinION nanopore sequencer: a feasibility study for perioperative precision medicine2022

    • Author(s)
      Tabata Yoshiteru、Matsuo Yoshiyuki、Fujii Yosuke、Ohta Atsufumi、Hirota Kiichi
    • Journal Title

      JA Clinical Reports

      Volume: 8 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s40981-022-00506-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] Establishment of a novel assessment of the quality of human spermatozoa measuring mitochondrial oxygen metabolism2022

    • Author(s)
      Taniguchi Hisanori、Matsuo Yoshiyuki、Shimoi Kayo、Yoshimura Masahiro、Hirota Kiichi、Kinoshita Hidefumi
    • Journal Title

      BMC Research Notes

      Volume: 15 Issue: 1 Pages: 123-123

    • DOI

      10.1186/s13104-022-06012-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-21K09438
  • [Journal Article] Successful identification of Granulicatella adiacens in postoperative acute infectious endophthalmitis using a bacterial 16S ribosomal RNA gene-sequencing platform with MinION?: A case report2022

    • Author(s)
      Ishino Masato、Omi Masatoshi、Araki-Sasaki Kaoru、Oba Shimpei、Yamada Haruhiko、Matsuo Yoshiyuki、Hirota Kiichi、Takahashi Kanji
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 26 Pages: 101524-101524

    • DOI

      10.1016/j.ajoc.2022.101524

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09106, KAKENHI-PROJECT-22K09802
  • [Journal Article] MinION, a portable long-read sequencer, enables rapid vaginal microbiota analysis in a clinical setting2022

    • Author(s)
      Komiya Shinnosuke、Matsuo Yoshiyuki、Nakagawa So、Morimoto Yoshiharu、Kryukov Kirill、Okada Hidetaka、Hirota Kiichi
    • Journal Title

      BMC Medical Genomics

      Volume: 15 Issue: 1 Pages: 68-68

    • DOI

      10.1186/s12920-022-01218-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-20K06612, KAKENHI-PROJECT-20K09419
  • [Journal Article] 16S rRNA nanopore sequencing for the diagnosis of ocular infection: a feasibility study2022

    • Author(s)
      Omi Masatoshi、Matsuo Yoshiyuki、Araki-Sasaki Kaoru、Oba Shimpei、Yamada Haruhiko、Hirota Kiichi、Takahashi Kanji
    • Journal Title

      BMJ Open Ophthalmology

      Volume: 7 Issue: 1 Pages: e000910-e000910

    • DOI

      10.1136/bmjophth-2021-000910

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09106, KAKENHI-PROJECT-22K09802
  • [Journal Article] Activation of transcription factor HIF inhibits IL-1β-induced NO production in primary cultured rat hepatocytes2022

    • Author(s)
      Yoshida Terufumi、Okumura Tadayoshi、Matsuo Yoshiyuki、Okuyama Tetsuya、Michiura Taku、Kaibori Masaki、Umezaki Nodoka、Bono Hidemasa、Hirota Kiichi、Sekimoto Mitsugu
    • Journal Title

      Nitric Oxide

      Volume: 124 Pages: 1-14

    • DOI

      10.1016/j.niox.2022.04.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09210
  • [Journal Article] Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION? nanopore sequencing confers species-level resolution2021

    • Author(s)
      Matsuo Yoshiyuki、Komiya Shinnosuke、Yasumizu Yoshiaki、Yasuoka Yuki、Mizushima Katsura、Takagi Tomohisa、Kryukov Kirill、Fukuda Aisaku、Morimoto Yoshiharu、Naito Yuji、Okada Hidetaka、Bono Hidemasa、Nakagawa So、Hirota Kiichi
    • Journal Title

      BMC Microbiology

      Volume: 21 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s12866-021-02094-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20K06612
  • [Journal Article] Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner2021

    • Author(s)
      Uba Takeo、Matsuo Yoshiyuki、Sumi Chisato、Shoji Tomohiro、Nishi Kenichiro、Kusunoki Munenori、Harada Hiroshi、Kimura Hideo、Bono Hidemasa、Hirota Kiichi
    • Journal Title

      Mitochondrion

      Volume: 59 Pages: 255-266

    • DOI

      10.1016/j.mito.2021.06.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal2021

    • Author(s)
      Tanimoto Keiji、Hirota Kiichi、Fukazawa Takahiro、Matsuo Yoshiyuki、Nomura Toshihito、Tanuza Nazmul、Hirohashi Nobuyuki、Bono Hidemasa、Sakaguchi Takemasa
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 16629-16629

    • DOI

      10.1038/s41598-021-96109-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-21K10073
  • [Journal Article] HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review2021

    • Author(s)
      Hirota Kiichi
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 5 Pages: 468-468

    • DOI

      10.3390/biomedicines9050468

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] 虚血・阻血による臓器障害メカニズムと耐性獲得戦略2021

    • Author(s)
      広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 28 Pages: 7-13

    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment2021

    • Author(s)
      Sakai Takayuki、Matsuo Yoshiyuki、Okuda Kensuke、Hirota Kiichi、Tsuji Mieko、Hirayama Tasuku、Nagasawa Hideko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 4852-4852

    • DOI

      10.1038/s41598-021-83708-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-19H03352, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-19K07035
  • [Journal Article] Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium2021

    • Author(s)
      Kida Naoko、Matsuo Yoshiyuki、Hashimoto Yoshiko、Nishi Kenichiro、Tsuzuki-Nakao Tomoko、Bono Hidemasa、Maruyama Tetsuo、Hirota Kiichi、Okada Hidetaka
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 1 Pages: 48-48

    • DOI

      10.3390/antiox10010048

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-20H03776, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-20H03826, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-21K09480
  • [Journal Article] Special Issue: Hypoxia-Inducible Factors: Regulation and Therapeutic Potential2021

    • Author(s)
      Hirota Kiichi
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 12 Pages: 1768-1768

    • DOI

      10.3390/biomedicines9121768

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] Hypoxia-dependent signaling in perioperative and critical care medicine2021

    • Author(s)
      Hirota Kiichi
    • Journal Title

      Journal of Anesthesia

      Volume: 35 Issue: 5 Pages: 741-756

    • DOI

      10.1007/s00540-021-02940-w

    • NAID

      40022700482

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] ミトコンドリアの酸素代謝異常と疾患2020

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 274 Pages: 248-252

    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] ARS-CoV-2感染と過剰炎症応答・サイトカインストーム勝敗の帰趨を決めるものは何か?2020

    • Author(s)
      広田 喜一, 藤井 庸祐
    • Journal Title

      Life Support and Anesthesia

      Volume: 27 Pages: 858-862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] ミトコンドリアの酸素代謝異常と疾患.2020

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 274 Pages: 248-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] Characterizing the gut microbiota in females with infertility and preliminary results of a water-soluble dietary fiber intervention study2020

    • Author(s)
      Komiya Shinnosuke、Naito Yuji、Okada Hidetaka、Matsuo Yoshiyuki、Hirota Kiichi、Takagi Tomohisa、Mizushima Katsura、Inoue Ryo、Abe Aya、Morimoto Yoshiharu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 67 Issue: 1 Pages: 105-111

    • DOI

      10.3164/jcbn.20-53

    • NAID

      130007867952

    • ISSN
      0912-0009, 1880-5086
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-17K11260
  • [Journal Article] Meta-Analysis of Hypoxic Transcriptomes from Public Databases.2020

    • Author(s)
      Bono H, Hirota K
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 1 Pages: 1-1

    • DOI

      10.3390/biomedicines8010010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-20H03776
  • [Journal Article] 周術期炎症マーカー:現状と課題,今後の展望 炎症応答の一歩先へ.2020

    • Author(s)
      松川 志乃, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 27 Pages: 858-862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] 周術期炎症マーカー:現状と課題,今後の展望 炎症応答の一歩先へ2020

    • Author(s)
      松川 志乃, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 27 Pages: 852-857

    • Data Source
      KAKENHI-PROJECT-20K09210
  • [Journal Article] Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and its Implication for Medicine2020

    • Author(s)
      Hirota K.
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 2 Pages: 2-2

    • DOI

      10.3390/biomedicines8020032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-20K09210, KAKENHI-PROJECT-20H03776
  • [Journal Article] 局所麻酔薬/プロポフォールとミトコンドリア障害:HIF-1活性化による障害軽滅の可能性2020

    • Author(s)
      広田 喜一
    • Journal Title

      Anet

      Volume: 24 Pages: 15-19

    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] ミトコンドリアの酸素代謝異常と疾患2020

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 274 Pages: 248-252

    • Data Source
      KAKENHI-PROJECT-18K08874
  • [Journal Article] 局所麻酔薬/プロポフォールとミトコンドリア障害:HIF-1活性化による障害軽滅の可能性.2020

    • Author(s)
      広田 喜一
    • Journal Title

      Anet

      Volume: 24 Pages: 15-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] 周術期炎症マーカー:現状と課題,今後の展望 炎症応答の一歩先へ2020

    • Author(s)
      松川 志乃, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 27 Pages: 852-857

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Journal Article] ミトコンドリアの酸素代謝異常と疾患2020

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 274 Pages: 248-252

    • Data Source
      KAKENHI-PROJECT-20K09210
  • [Journal Article] Thyroid Hormone Facilitates in vitro Decidualization of Human Endometrial Stromal Cells via Thyroid Hormone Receptors2020

    • Author(s)
      Kakita-Kobayashi Maiko、Murata Hiromi、Nishigaki Akemi、Hashimoto Yoshiko、Komiya Shinnosuke、Tsubokura Hiroaki、Kido Takeharu、Kida Naoko、Tsuzuki-Nakao Tomoko、Matsuo Yoshiyuki、Bono Hidemasa、Hirota Kiichi、Okada Hidetaka
    • Journal Title

      Endocrinology

      Volume: 161 Issue: 6

    • DOI

      10.1210/endocr/bqaa049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-17K11260
  • [Journal Article] Deactivation of Glutaminolysis Sensitizes PIK3CA-Mutated Colorectal Cancer Cells to Aspirin-Induced Growth Inhibition.2020

    • Author(s)
      Boku S, Watanabe M, Sukeno M, Yaoi T, Hirota K, Iizuka-Ohashi M, Itoh K, Sakai T.
    • Journal Title

      Cancers (Basel).

      Volume: 12 Issue: 5 Pages: 1097-1097

    • DOI

      10.3390/cancers12051097

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K23179, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-18K19693
  • [Journal Article] Real-time diagnostic analysis of MinION-based metagenomic sequencing in clinical microbiology evaluation: a case report2019

    • Author(s)
      Hiromasa Tanaka, Yoshiyuki Matsuo, So Nakagawa, Kenichiro Nishi, Akihisa Okamoto, Shinichi Kai, Teppei Iwai, Yoshiteru Tabata, Takeshi Tajima, Yuji Komatsu, Motohiko Satoh, Kirill Kryukov, Tadashi Imanishi, Kiichi Hirota
    • Journal Title

      JA Clinical Reports

      Volume: 5 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s40981-019-0244-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07123, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-19K09339, KAKENHI-PROJECT-18K16501
  • [Journal Article] Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION nanopore sequencer2019

    • Author(s)
      Shinichi Kai, Yoshiyuki Matsuo, So Nakagawa, Kirill Kryukov, Shino Matsukawa, Hiromasa Tanaka, Teppei Iwai, Tadashi Imanishi, Kiichi Hirota
    • Journal Title

      FEBS Open Bio

      Volume: 9 Issue: 3 Pages: 548-557

    • DOI

      10.1002/2211-5463.12590

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07123, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-19K09339
  • [Journal Article] 【ノーベル生理学・医学賞2019】低酸素生物学から酸素・エネルギー生物学へ2019

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 271 Pages: 1251-1253

    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs)2019

    • Author(s)
      Hirota K
    • Journal Title

      Free Radic Biol Med

      Volume: 133 Pages: 118-29

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874
  • [Journal Article] Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma2019

    • Author(s)
      Sumi Chisato、Matsuo Yoshiyuki、Kusunoki Munenori、Shoji Tomohiro、Uba Takeo、Iwai Teppei、Bono Hidemasa、Hirota Kiichi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 4 Pages: e0215072-e0215072

    • DOI

      10.1371/journal.pone.0215072

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-19K18256
  • [Journal Article] An intimate crosstalk between iron homeostasis and oxygen metabolism regulated by the hypoxia-inducible factors (HIFs)2019

    • Author(s)
      Hirota Kiichi
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 133 Pages: 118-129

    • DOI

      10.1016/j.freeradbiomed.2018.07.018

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-16K10974
  • [Journal Article] 酸素生物学の建設 ― 生体の酸素利用の方程式 ―2019

    • Author(s)
      広田 喜一
    • Journal Title

      現代化学

      Volume: 585 Pages: 29-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08874
  • [Journal Article] 29-322019

    • Author(s)
      広田 喜一
    • Journal Title

      実験医学

      Volume: 37 Pages: 3249-50

    • Data Source
      KAKENHI-PROJECT-18K08874
  • [Journal Article] 2019年ノーベル生理学・医学賞解説レビュー 酸素生物学の「現代」の建設,2019

    • Author(s)
      広田 喜一
    • Journal Title

      実験医学

      Volume: 37 Pages: 3249-3250

    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Journal Article] 酸素生物学を読み解く 低酸素誘導性因子研究の今昔物語2018

    • Author(s)
      広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 25 Pages: 897-905

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss2018

    • Author(s)
      Hirai K, Furusho H, Hirota K, Sasaki H
    • Journal Title

      Int J Oral Sci

      Volume: 10 Issue: 2 Pages: 12-12

    • DOI

      10.1038/s41368-018-0015-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K15682
  • [Journal Article] 小胞体内レドックスバランスの維持機構2018

    • Author(s)
      松尾 禎之, 広田 喜一
    • Journal Title

      細胞

      Volume: 50 Pages: 208-209

    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Journal Article] 小胞体内レドックスバランスの維持機構2018

    • Author(s)
      松尾 禎之, 広田 喜一
    • Journal Title

      細胞

      Volume: 50 Pages: 208-209

    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Journal Article] Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity2018

    • Author(s)
      Sumi Chisato、Okamoto Akihisa、Tanaka Hiromasa、Kusunoki Munenori、Shoji Tomohiro、Uba Takeo、Adachi Takehiko、Iwai Teppei、Nishi Kenichiro、Harada Hiroshi、Bono Hidemasa、Matsuo Yoshiyuki、Hirota Kiichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8987-8987

    • DOI

      10.1038/s41598-018-27220-8

    • NAID

      120006539570

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08874, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-18K16501, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975
  • [Journal Article] Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner2018

    • Author(s)
      Sumi Chisato、Okamoto Akihisa、Tanaka Hiromasa、Nishi Kenichiro、Kusunoki Munenori、Shoji Tomohiro、Uba Takeo、Matsuo Yoshiyuki、Adachi Takehiko、Hayashi Jun-Ichi、Takenaga Keizo、Hirota Kiichi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0192796-e0192796

    • DOI

      10.1371/journal.pone.0192796

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-16K15682, KAKENHI-PROJECT-18K08877, KAKENHI-PROJECT-18K16501
  • [Journal Article] 低酸素の生物学―低酸素誘導性因子(HIF)の果たす役割2018

    • Author(s)
      広田 喜一
    • Journal Title

      Intensivist

      Volume: 10 Pages: 259-269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] Transmembrane thioredoxin-related protein TMX1 is reversibly oxidized in response to protein accumulation in the endoplasmic reticulum2017

    • Author(s)
      Matsuo Yoshiyuki, Hirota Kiichi
    • Journal Title

      FEBS Open Bio

      Volume: 7 Issue: 11 Pages: 1768-1777

    • DOI

      10.1002/2211-5463.12319

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Journal Article] 「酸素はいつも足りていない」の生物学の建設:2016年度アルバート・ラスカー基礎医学研究賞の発表に寄せて2017

    • Author(s)
      松尾禎之、広田喜一
    • Journal Title

      LiSA

      Volume: 24 Issue: 2 Pages: 194-196

    • DOI

      10.11477/mf.3101200789

    • NAID

      40021124698

    • ISSN
      1340-8836, 1883-5511
    • Year and Date
      2017-02-01
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Journal Article] 「酸素はいつも足りていない」の生物学の建設 - 2016年度アルバート・ラスカー基礎医学研究賞の発表に寄せて2017

    • Author(s)
      松尾 禎之, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 24 Pages: 194-196

    • NAID

      40021124698

    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Journal Article] Transmembrane thioredoxin-related protein TMX1 is reversibly oxidized in response to protein accumulation in the endoplasmic reticulum2017

    • Author(s)
      Matsuo Y, Hirota K
    • Journal Title

      FEBS Open Bio

      Volume: 7 Pages: 1768-1777

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death2017

    • Author(s)
      Okamoto Akihisa、Sumi Chisato、Tanaka Hiromasa、Kusunoki Munenori、Iwai Teppei、Nishi Kenichiro、Matsuo Yoshiyuki、Harada Hiroshi、Takenaga Keizo、Bono Hidemasa、Hirota Kiichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 3816-3816

    • DOI

      10.1038/s41598-017-03980-7

    • NAID

      120006364104

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975, KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-17H04261, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15682
  • [Journal Article] Mitigation of inflammation using the intravenous anesthetic dexmedetomidine in the mouse air pouch model2017

    • Author(s)
      Inada Takefumi, Sumi Chisato, Hirota Kiichi, Shingu Koh, Okamoto Akihisa, Matsuo Yoshiyuki, Kamibayashi Takahiko
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: 39 Issue: 4 Pages: 225-232

    • DOI

      10.1080/08923973.2017.1327964

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Journal Article] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する2016

    • Author(s)
      甲斐 慎一, 広田 喜一
    • Journal Title

      ICUとCCU

      Volume: 40 Pages: 549-554

    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] 「酸素はいつも足りていない」の生物学の建設 - 2016年度アルバート・ラスカー基礎医学研究賞の発表に寄せて2016

    • Author(s)
      松尾 禎之, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 24 Pages: 194-196

    • NAID

      40021124698

    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] Oxygen, Hypoxia & Beyond -2016年アルバート・ラスカー基礎医学賞に寄せて2016

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 961-963

    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Journal Article] VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway2016

    • Author(s)
      Yamaguchi R, Harada H, Hirota K
    • Journal Title

      Tumor Biology

      Volume: 37 Issue: 10 Pages: 13295-13306

    • DOI

      10.1007/s13277-016-5260-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-26293276, KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-16K15682, KAKENHI-PROJECT-15K10551
  • [Journal Article] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する2016

    • Author(s)
      甲斐 慎一, 広田 喜一
    • Journal Title

      ICUとCCU

      Volume: 40 Pages: 549-554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Journal Article] Oxygen, Hypoxia & Beyond -2016年アルバート・ラスカー基礎医学賞に寄せて2016

    • Author(s)
      広田 喜一
    • Journal Title

      医学のあゆみ

      Volume: 259 Pages: 961-963

    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Journal Article] VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway2016

    • Author(s)
      Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota
    • Journal Title

      Tumor Biology,

      Volume: accepted for publication

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25430108
  • [Journal Article] Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner2016

    • Author(s)
      Daijo H, Hoshino Y, Kai S, Suzuki K, Nishi K, Matsuo Y, Harada H, Hirota K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 34424-34424

    • DOI

      10.1038/srep34424

    • NAID

      120005850269

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-16H01573, KAKENHI-PUBLICLY-16H01640, KAKENHI-PROJECT-26293276, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-16K15576, KAKENHI-PROJECT-15K10551
  • [Journal Article] The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells2016

    • Author(s)
      Okamoto A, Tanaka M, Sumi C, Oku K, Kusunoki M, Nishi K, Matsuo Y, Takenaga K, Shingu K, Hirota K
    • Journal Title

      BMC Anesthesiol

      Volume: 16 Issue: 1 Pages: 104-104

    • DOI

      10.1186/s12871-016-0273-3

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K10974, KAKENHI-PROJECT-16K10975, KAKENHI-PROJECT-16K15682, KAKENHI-PROJECT-15K10551
  • [Journal Article] 「酸素はいつも足りていない」の生物学の建設 - 2016年度アルバート・ラスカー基礎医学研究賞の発表に寄せて2016

    • Author(s)
      松尾 禎之, 広田 喜一
    • Journal Title

      Life Support and Anesthesia

      Volume: 24 Pages: 194-196

    • NAID

      40021124698

    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Journal Article] Involvement of hypozia-inducible factors in the dysregulation of oxygen homeostasis in sepsis2015

    • Author(s)
      Hirota K.
    • Journal Title

      Cardiovascular & hematological disorders drug targets

      Volume: 15 Issue: 1 Pages: 29-40

    • DOI

      10.2174/1871529x15666150108115553

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-25462457, KAKENHI-PROJECT-26670693
  • [Journal Article] Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1.2015

    • Author(s)
      Suzuki K, Sato Y, Kai S, Nishi K, Adachi T, Matsuo Y, Hirota K.
    • Journal Title

      PeerJ.

      Volume: 3 Pages: 1498-1498

    • DOI

      10.7717/peerj.1498

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K20063, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-26860697
  • [Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha2015

    • Author(s)
      Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 1-10

    • DOI

      10.1038/ncomms7153

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26462125, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-25462457, KAKENHI-PROJECT-26293276
  • [Journal Article] Targeting cholesterol with beta-cyclodextrin sensitizes cancer cells for apoptosis2015

    • Author(s)
      Yamaguchi R, Perkins G, Hirota K
    • Journal Title

      FEBS Lett

      Volume: 589 Issue: 24PartB Pages: 4097-4105

    • DOI

      10.1016/j.febslet.2015.11.009

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-25430108
  • [Journal Article] The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner2014

    • Author(s)
      Kai S, Tanaka T, Matsuyama T, Suzuki K, Hirota K
    • Journal Title

      Eur J Pharmacol

      Volume: 732C Pages: 43-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] 肺胞低酸素と炎症-低酸素誘導性因子活性化の視点から-2014

    • Author(s)
      広田喜一
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 73-5

    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] 肺内酸素環境と肺疾患 -低酸素-HIF-炎症-.2014

    • Author(s)
      広田 喜一
    • Journal Title

      呼吸器内科.

      Volume: 25 Pages: 270-275

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] 肺胞低酸素と炎症 -低酸素誘導性因子活性化の視点から-2014

    • Author(s)
      広田喜一
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-24592336
  • [Journal Article] 肺内酸素環境と肺疾患 -低酸素-HIF-炎症-2014

    • Author(s)
      広田喜一
    • Journal Title

      呼吸器内科

      Volume: 25 Pages: 270-275

    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] 肺内酸素環境と肺疾患 -低酸素-HIF-炎症-2014

    • Author(s)
      広田 喜一
    • Journal Title

      呼吸器内科

      Volume: 25 Pages: 270-275

    • Data Source
      KAKENHI-PROJECT-26670693
  • [Journal Article] The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner.2014

    • Author(s)
      Kai S, Tanaka T, Matsuyama T, Suzuki K, Hirota K.
    • Journal Title

      Eur J Pharmacol.

      Volume: 732C Pages: 43-49

    • DOI

      10.1016/j.ejphar.2014.03.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-25462457, KAKENHI-PROJECT-26670693
  • [Journal Article] 肺胞低酸素と炎症 -低酸素誘導性因子活性化の視点から-2014

    • Author(s)
      広田喜一
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] 肺内酸素環境と肺疾患 -低酸素-HIF-炎症-2014

    • Author(s)
      広田喜一
    • Journal Title

      呼吸器内科

      Volume: 25 Pages: 270-275

    • Data Source
      KAKENHI-PROJECT-24592336
  • [Journal Article] 肺胞低酸素と炎症-低酸素誘導性因子活性化の視点から-2014

    • Author(s)
      広田喜一
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] 肺内酸素環境と肺疾患-低酸素-HIF-炎症-2014

    • Author(s)
      広田喜一
    • Journal Title

      呼吸器内科

      Volume: 25 Pages: 270-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis.2014

    • Author(s)
      Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T,Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H.
    • Journal Title

      Oncogene

      Volume: epub Issue: 36 Pages: 4758-4766

    • DOI

      10.1038/onc.2014.411

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-26293276
  • [Journal Article] 肺内酸素環境と肺疾患-低酸素-HIF1-炎症-2014

    • Author(s)
      広田喜一
    • Journal Title

      呼吸器内科

      Volume: 25 Pages: 270-275

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] 肺胞低酸素と炎症 -低酸素誘導性因子活性化の視点から-.2014

    • Author(s)
      広田喜一
    • Journal Title

      分子呼吸器病.

      Volume: 18 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] 肺胞低酸素と炎症 -低酸素誘導性因子活性化の視点から-2014

    • Author(s)
      広田 喜一
    • Journal Title

      分子呼吸器病

      Volume: 18 Pages: 73-75

    • Data Source
      KAKENHI-PROJECT-26670693
  • [Journal Article] Macrophage migration inhibitory factor diminishes muscle glucose transport induced by insulin and AICAR in a muscle type-dependent manner2014

    • Author(s)
      Miyatake S, Manabe Y, Inagaki A, Furuichi Y, Takagi M, Taoka M, Isobe T, Hirota K, Fujii NL
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 444 Pages: 496-501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-12013

    • Author(s)
      Y. Liu, H. Higashitsuji, K. Itoh, T. Sakurai, K. Koike, K. Hirota, M. Fukumoto, J. Fujita
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 432 Issue: 1 Pages: 22-27

    • DOI

      10.1016/j.bbrc.2013.01.093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-23590998, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24592446, KAKENHI-PROJECT-24659174, KAKENHI-PROJECT-24659695
  • [Journal Article] 疾患の病態生理学と低酸素誘導性因子2013

    • Author(s)
      広田喜一
    • Journal Title

      細胞

      Volume: 45 Pages: 415-418

    • Data Source
      KAKENHI-PROJECT-24592336
  • [Journal Article] 疾患の病態生理学と低酸素誘導性因子2013

    • Author(s)
      広田喜一
    • Journal Title

      細胞

      Volume: 45 Pages: 415-418

    • Data Source
      KAKENHI-PROJECT-25462457
  • [Journal Article] Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-12013

    • Author(s)
      Liu Y, Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Koike K, Hirota K, Fukumoto M, Fujita J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 132 Pages: 22-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells2013

    • Author(s)
      Zhu Y, Zhao T, Itasaka S, Zeng L, Yeom CJ, Hirota K, Suzuki K, Morinibu A, Shinomiya K, Ou G, Yoshimura M, Hiraoka M, Harada H
    • Journal Title

      Oncogene

      Volume: 32 Pages: 2058-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] General Anesthetics Inhibit LPS-Induced IL-1beta Expression in Glial Cells.2013

    • Author(s)
      Tanaka T, Kai S, Matsuyama T, Adachi T, Fukuda K, Hirota K.
    • Journal Title

      PLoS ONE.

      Volume: 8 Issue: 12 Pages: 82930-82930

    • DOI

      10.1371/journal.pone.0082930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-25462432
  • [Journal Article] 疾患の病態生理学と低酸素誘導性因子.2013

    • Author(s)
      広田喜一
    • Journal Title

      細胞.

      Volume: 45 Pages: 415-418

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells2013

    • Author(s)
      Y. Zhu, T. Zhao, S. Itasaka, L. Zeng, C.J. Yeom, K. Hirota, K. Suzuki, A. Morinibu, K. Shinomiya, G. Ou, M. Yoshimura, M. Hiraoka, H. Harada
    • Journal Title

      Oncogene

      Volume: 32 Issue: 16 Pages: 2058-2068

    • DOI

      10.1038/onc.2012.223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-24791293
  • [Journal Article] Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.2013

    • Author(s)
      Suzuki K, Nishi K, Takabuchi S, Kai S, Matsuyama T, Kurosawa S, Adachi T, Maruyama T, Fukuda K, Hirota K.
    • Journal Title

      PeerJ.

      Volume: 1 Pages: 220-220

    • DOI

      10.7717/peerj.220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-25462395, KAKENHI-PROJECT-25462457
  • [Journal Article] 疾患の病態生理学と低酸素誘導性因子2013

    • Author(s)
      広田喜一
    • Journal Title

      細胞

      Volume: 45 Pages: 415-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する2013

    • Author(s)
      広田喜一
    • Journal Title

      Medical Gases

      Volume: 15 Pages: 25-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner2012

    • Author(s)
      Kai S, Tanaka T, Daijo H, Harada H, Kishimoto S, Suzuki K, Takabuchi S, Takenaga K, Fukuda K, Hirota K
    • Journal Title

      Antioxidants & redox signaling

      Volume: 16 Pages: 203-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Hypoxia and hypoxia-inducible factor in inflammation2012

    • Author(s)
      Kiichi, Hirota
    • Journal Title

      Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions

      Volume: 1 Pages: 51-65

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] Hypoxia and hypoxia-inducible factor in inflammation2012

    • Author(s)
      Kiichi, Hirota
    • Journal Title

      Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions

      Volume: 1 Pages: 51-56

    • Data Source
      KAKENHI-PROJECT-24592336
  • [Journal Article] Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats2012

    • Author(s)
      Kawano Y, Kawaguchi M, Hirota K, Kai S, Konishi N, Furuya H
    • Journal Title

      Resuscitation

      Volume: Vol.83,No2 Pages: 249-52

    • Data Source
      KAKENHI-PROJECT-21591984
  • [Journal Article] グルタミノリシス2012

    • Author(s)
      広田喜一
    • Journal Title

      がんと代謝(実験医学増刊)(東京 : 羊土社)(朋義曽,浩安江, editors)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Hypoxia and hypoxia-inducible factor in inflammation2012

    • Author(s)
      Kiichi, Hirota
    • Journal Title

      Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions

      Volume: 1 Pages: 51-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats2012

    • Author(s)
      Y. Kawano, M. Kawaguchi, K. Hirota, S. Kai, N. Konishi, H. Furuya
    • Journal Title

      Resuscitation

      Volume: 83 Issue: 2 Pages: 249-252

    • DOI

      10.1016/j.resuscitation.2011.07.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659283, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659695
  • [Journal Article] グルタミノリシス2012

    • Author(s)
      広田喜一
    • Journal Title

      実験医学

      Volume: 30 Pages: 2400-2406

    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Hypoxia and hypoxia-inducible factor in inflammation2012

    • Author(s)
      Kiichi, Hirota
    • Journal Title

      Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions

      Volume: 1 Pages: 51-65

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] グルタミノリシス2012

    • Author(s)
      広田喜一
    • Journal Title

      実験医学

      Volume: 30 Pages: 2400-2406

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] グルタミノリシス2012

    • Author(s)
      広田喜一
    • Journal Title

      実験医学

      Volume: 30 Pages: 2400-2406

    • Data Source
      KAKENHI-PROJECT-24592322
  • [Journal Article] Effects of n-propyl gallate on neuronal survival after forebrain ischemia in rats2012

    • Author(s)
      Kawano Y, Kawaguchi M, Hirota K, Kai S, Konishi N, Furuya H
    • Journal Title

      Resuscitation

      Volume: 83 Pages: 249-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels2012

    • Author(s)
      Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna WG, Muschel RJ, Hiraoka M
    • Journal Title

      Nature communications

      Volume: 3 Pages: 783-783

    • NAID

      120004007582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] グルタミノリシス2012

    • Author(s)
      広田喜一
    • Journal Title

      実験医学

      Volume: 30 Pages: 2400-2406

    • Data Source
      KAKENHI-PROJECT-24592336
  • [Journal Article] Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels2012

    • Author(s)
      H. Harada, M. Inoue, S. Itasaka, K. Hirota,A. Morinibu, K. Shinomiya, L. Zeng, G. Ou, Y. Zhu, M. Yoshimura, W.G. McKenna, R.J. Muschel, M. Hiraoka
    • Journal Title

      Nature communications

      Volume: 3 Issue: 1 Pages: 783-783

    • DOI

      10.1038/ncomms1786

    • NAID

      120004007582

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-24659695, KAKENHI-PROJECT-24791293
  • [Journal Article] Hypoxia and hypoxia-inducible factor in inflammation2012

    • Author(s)
      Hirota K
    • Journal Title

      In : Roy S, editor. Chronic Inflammation : Molecular Pathophysiology, Nutritional and Therapeutic Interventions : Taylor & Francis

      Pages: 51-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxiainducible transcription factor-based in vive bioluminescence imaging2011

    • Author(s)
      Harada, H., Inoue, M., Itasaka, S., Hirota, K., Morinibu, A., Shinomiya, K., Kadonosono, T., Kuchimaru, T., Yamada, S., Takahashi, Y., Murakami, A., Tani, T., Watanabe, H., Tanaka, T., Hirota, K., Inoue, M., et al
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: 2664-2664

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] 周術期医学としてのハイポキシア生物学の探究2011

    • Author(s)
      広田喜一
    • Journal Title

      麻酔

      Volume: 60

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] 周術期医学としてのハイポキシア生物学の探究2011

    • Author(s)
      広田 喜一
    • Journal Title

      麻酔

      Volume: 60

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一, 大条鉱樹, 甲斐慎一, 鈴木堅悟, 岸本俊, and松山智紀
    • Journal Title

      麻酔

      Volume: 60 Pages: 69-74

    • URL

      http://jglobaljst.gojp/public/20090422/201102269918990320

    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] 周術期医学としてのハイポキシア生物学の探究2011

    • Author(s)
      広田喜一
    • Journal Title

      麻酔

      Volume: 60 Pages: 183-188

    • URL

      http://jglobaljst.gojp/public/20090422/201102221994057673

    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner.2011

    • Author(s)
      大条紘樹、甲斐慎一、田中具治、若松拓彦、岸本俊、鈴木堅悟、原田浩、高淵聡史、足立健彦、福田和彦、広田喜一
    • Journal Title

      Eur J Pharmacol

      Volume: 667 Issue: 1-3 Pages: 144-152

    • DOI

      10.1016/j.ejphar.2011.06.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659282, KAKENHI-PROJECT-22659283, KAKENHI-PROJECT-22791428, KAKENHI-PROJECT-22791429
  • [Journal Article] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一, 他
    • Journal Title

      麻酔

      Volume: 60

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一,大条鉱樹,甲斐慎一,鈴木堅悟,岸本俊,松山智紀
    • Journal Title

      麻酔

      Volume: 60

    • URL

      http://jglobal.jst.go.jp/public/20090422/201102269918990320

    • Data Source
      KAKENHI-PROJECT-21591992
  • [Journal Article] Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging2011

    • Author(s)
      Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y. Murakami A, Watanabe H, Tani T, Inoue M, Tsukamoto T, Toyoda T, Tanaka T, Hirota K, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S
    • Journal Title

      PLoS ONE

      Volume: 6(11) Issue: 11 Pages: e26640-e26640

    • DOI

      10.1371/journal.pone.0026640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21240049, KAKENHI-ORGANIZER-22112001, KAKENHI-PLANNED-22112009, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659283, KAKENHI-PROJECT-22700469, KAKENHI-PROJECT-22700935
  • [Journal Article] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一, 他
    • Journal Title

      麻酔

      Volume: 60

    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner.2011

    • Author(s)
      甲斐慎一、田中具治、大条紘樹、原田浩、岸本俊、鈴木堅悟、高淵聡史、竹永敬三、福田和彦、広田喜一
    • Journal Title

      Antioxid Redox Signal

      Volume: 16 Issue: 3 Pages: 203-216

    • DOI

      10.1089/ars.2011.3882

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659282, KAKENHI-PROJECT-22659283, KAKENHI-PROJECT-22791428, KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24659695
  • [Journal Article] General anesthetics inhibit erythropoietin induction under hypoxic conditions in the mouse brain.2011

    • Author(s)
      田中具治、甲斐慎一、小山智弘、大条紘樹、足立健彦、福田和彦、広田喜一
    • Journal Title

      PLoS One

      Volume: 6 Issue: 12 Pages: 29378-29378

    • DOI

      10.1371/journal.pone.0029378

    • NAID

      120003726125

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659282, KAKENHI-PROJECT-22659283
  • [Journal Article] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田 喜一, 大条 鉱樹, 甲斐 慎一, 鈴木堅悟, 岸本 俊, 松山 智紀
    • Journal Title

      麻酔

      Volume: 60

    • Data Source
      KAKENHI-PROJECT-22390298
  • [Journal Article] Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.2010

    • Author(s)
      田中具治、若松拓彦、大条紘樹、小田聖子、甲斐慎一、足立健彦、木坂(近藤)科江、福田和彦、広田喜一
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 298 Issue: 3 Pages: 661-671

    • DOI

      10.1152/ajpregu.00732.2009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21249081, KAKENHI-PROJECT-21591992, KAKENHI-PROJECT-22390298, KAKENHI-PROJECT-22659283
  • [Journal Article] The intravenous anesthetic propofol inhibits lipopolysaccharideinduced hypoxiainducible factor 1 activation and suppresses the glucose metabolism in macrophages2010

    • Author(s)
      Tanaka, T., Takabuchi, S., Nishi, K., Oda, S., Wakamatsu, T., Daijo, H., Fukuda, K., and Hirota, K
    • Journal Title

      J Anesth

      Volume: 24 Pages: 54-60

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda, S., Oda, T., Takabuchi, S., Nishi, K., Wakamatsu, T., Tanaka, T., Adachi, T., Fukuda, K., Nohara, R., and Hirota, K.
    • Journal Title

      Eur J Pharmacol

      Volume: 606 Issue: 1-3 Pages: 130-136

    • DOI

      10.1016/j.ejphar.2009.01.012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda S, Oda T, Takabuchi S, Nishi K, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Nohara R, Hirota K
    • Journal Title

      Eur J Pharmacol 606

      Pages: 130-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda S, Oda T, Takabuchi S, Nishi K, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Nohara R, Hirota K
    • Journal Title

      Eur J Pharmacol 606

      Pages: 130-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009

    • Author(s)
      Oda S, Oda T, Takabuchi S, Nishi K, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Nohara R, Hirota K
    • Journal Title

      Eur J Pharmacol 606

      Pages: 130-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] ハイポキシア生物学-酸素代謝から見る生命現象-2009

    • Author(s)
      広田喜一,若松拓彦,田中具治,大条鉱樹,甲斐慎一
    • Journal Title

      麻酔

      Volume: 58

    • Data Source
      KAKENHI-PROJECT-21591992
  • [Journal Article] ハイポキシア生物学と周術期医学2009

    • Author(s)
      広田喜一
    • Journal Title

      臨床麻酔 33

      Pages: 1911-1919

    • Data Source
      KAKENHI-PROJECT-21591992
  • [Journal Article] n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems2008

    • Author(s)
      Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
    • Journal Title

      Biochem J 411

      Pages: 97-105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] ハイポキシア生物学-酸素代謝からみる生命現象の方程式2008

    • Author(s)
      広田喜一
    • Journal Title

      医学のあゆみ 225

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner2008

    • Author(s)
      Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K
    • Journal Title

      Antioxid Redox Signal 10

      Pages: 983-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner2008

    • Author(s)
      Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K
    • Journal Title

      Antioxid Redox Signal 10

      Pages: 983-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2008

    • Author(s)
      Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K
    • Journal Title

      PLoS ONE 3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems2008

    • Author(s)
      Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
    • Journal Title

      Biochem J 411

      Pages: 97-105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2008

    • Author(s)
      Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K
    • Journal Title

      PLoS ONE 3

      Pages: 2215-2215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2008

    • Author(s)
      Oda S, Oda T, Nishi K, Takabuchi S, Wakamatsu T, Tanaka T, Adachi T, Fukuda K, Semenza GL, Hirota K
    • Journal Title

      PLoS ONE 3

      Pages: 2215-2215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] ハイポキシア生物学-酸素代謝からみる生命現象の方程式2008

    • Author(s)
      広田喜一
    • Journal Title

      医学のあゆみ 225

    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner2008

    • Author(s)
      Nishi K, Oda T, Takabuchi S, Oda S, Fukuda K, Adachi T, Semenza GL, Shingu K, Hirota K
    • Journal Title

      Antioxid Redox Signal 10

      Pages: 983-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems2008

    • Author(s)
      Kimura M, Takabuchi S, Tanaka T, Murata M, Nishi K, Oda S, Oda T, Kanai M, Fukuda K, Kizaka-Kondoh S, Adachi T, Takabayashi A, Semenza GL, Hirota K
    • Journal Title

      Biochem J 411

      Pages: 97-105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] 低酸素応答と低酸素センサー2008

    • Author(s)
      広田喜一, 田中具治
    • Journal Title

      Life Support and Anesthesia 15

      Pages: 238-43

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] 低酸素応答と低酸素センサー2008

    • Author(s)
      広田喜一, 田中具治
    • Journal Title

      Life Support and Anesthesia 15

      Pages: 238-43

    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] 細胞の低酸素応答機構-低酸素センサーを巡る論争2007

    • Author(s)
      広田喜一
    • Journal Title

      実験医学 25

      Pages: 2120-6

    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer2007

    • Author(s)
      Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T
    • Journal Title

      Cancer research 67

      Pages: 4157-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] 細胞の低酸素応答機構-低酸素センサーを巡る論争2007

    • Author(s)
      広田 喜一
    • Journal Title

      実験医学 25

      Pages: 2120-2126

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer2007

    • Author(s)
      Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T
    • Journal Title

      Cancer research 67

      Pages: 4157-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Inhibitory Effect of 6-Formylpterin on HIF-1alpha Protein Accumulation2007

    • Author(s)
      Sommani P, Yamashita K, Miyoshi T, Tsunemine H, Kodaki T, Mori H, Hirota K, Arai T, Sasada M, Makino K
    • Journal Title

      Biol Pharm Bull 30

      Pages: 2181-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-γ in human proximal renal tubular cells2007

    • Author(s)
      Li X, Kimura H, Hirota K, Sugimoto H, Kimura N, Takahashi N, Fujii H, Yoshida H
    • Journal Title

      Nephrol Dialysis Transplant 22

      Pages: 1041-1051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590944
  • [Journal Article] Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia2007

    • Author(s)
      Adachi T, Hirota K, Hara T, Sasaki Y, Hara Y
    • Journal Title

      Anesth Analg 105

      Pages: 696-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia2007

    • Author(s)
      Adachi T, Hirota K, Hara T, Sasaki Y, Hara Y
    • Journal Title

      Anesth Analg 105

      Pages: 696-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] 細胞の低酸素応答機構-低酸素センサーを巡る論争2007

    • Author(s)
      広田喜一
    • Journal Title

      実験医学 25

      Pages: 2120-6

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] 細胞の低酸素応答機構-低酸素センサーを巡る論争2007

    • Author(s)
      広田 喜一
    • Journal Title

      実験医学 25

      Pages: 2120-2126

    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer2007

    • Author(s)
      Hiraga T, Kizaka-Kondoh S, Hirota K, Hiraoka M, Yoneda T
    • Journal Title

      Cancer research 67

      Pages: 4157-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] 細胞の低酸素応答機構-低酸素センサーを巡る論争2007

    • Author(s)
      広田 喜一
    • Journal Title

      実験医学 25

      Pages: 2120-2126

    • Data Source
      KAKENHI-PROJECT-19659396
  • [Journal Article] Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-g in human proximal renal tubular cells2007

    • Author(s)
      Li X, Kimura H, Hirota K, Sugimoto H, Kimura N, Takahashi N, Fujii H, Yoshida H
    • Journal Title

      Nephrol Dial Transplant 22

      Pages: 1041-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-g in human proximal renal tubular cells2007

    • Author(s)
      Li X, Kimura H, Hirota K, Sugimoto H, Kimura N, Takahashi N, Fujii H, Yoshida H
    • Journal Title

      Nephrol Dial Transplant 22

      Pages: 1041-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Inhibitory Effect of 6-Formylpterin on HIF-1alpha Protein Accumulation2007

    • Author(s)
      Sommani P, Yamashita K, Miyoshi T, Tsunemine H, Kodaki T, Mori H, Hirota K, Arai T, Sasada M, Makino K
    • Journal Title

      Biol Pharm Bull 30

      Pages: 2181-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Journal Article] Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-g in human proximal renal tubular cells2007

    • Author(s)
      Li X, Kimura H, Hirota K, Sugimoto H, Kimura N, Takahashi N, Fujii H, Yoshida H
    • Journal Title

      Nephrol Dial Transplant 22

      Pages: 1041-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Journal Article] Adenoviral Transduction of MRP-1/CD9 and KAI1/CD82 Inhibits Lymph Node Metastasis in Orthotopic Lung Cancer Model2007

    • Author(s)
      Takeda, T., Hattori, N., Tokuhara, T., Nishimura, Y., Yokoyama, M., and Miyake, M.
    • Journal Title

      Cancer Res 67

      Pages: 1744-1749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591571
  • [Journal Article] Regulation of Angiogenesis by Hypoxia-Inducible Factor 1.2006

    • Author(s)
      Hirota, K., G.Semenza
    • Journal Title

      Crit Rev Oncol Hematol (In press)

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Regulation of angiogenesis by hypoxia-inducible factor 1.2006

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Crit. Rev. Oncol. Hematol. 59

      Pages: 15-26

    • Data Source
      KAKENHI-PROJECT-18591571
  • [Journal Article] Activation of hypoxia-inducible factor 1 during macrophage differentiation2006

    • Author(s)
      Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R
    • Journal Title

      Am J Physiol Cell Physiol 291

      Pages: 104-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Activation of hypoxia-inducible factor 1 during macrophage differentiation2006

    • Author(s)
      Oda, T., Hirota, K, Nishi, K., Takabuchi, S., Oda, S., Yamada, H., Arai, T., Fukuda, K., Kita, T., Adachi, T., et al.
    • Journal Title

      Am J Physiol Cell Physiol

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Gallate, the component of HIF-inducing catechins, inhibits HIF prolyl hydroxylase2006

    • Author(s)
      Tsukiyama F, Nakai Y, Yoshida M, Tokuhara T, Hirota K, Sakai A, Hayashi H, Katsumata T
    • Journal Title

      Biochem Biophys Res Commun 35

      Pages: 234-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] 低酸素センサー-細胞は低酸素をいかに関知するか-2006

    • Author(s)
      広田喜一
    • Journal Title

      Anesthesia Network 10

      Pages: 11-15

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Regulation of angiogenesis by hypoxia-inducible factor 12006

    • Author(s)
      Hirota K, Semenza GL
    • Journal Title

      Crit Rev Oncol Hematol 59

      Pages: 15-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Regulation of angiogenesis by hypoxia-inducible factor 12006

    • Author(s)
      Hirota, K., Semenza, GL.
    • Journal Title

      Crit Rev Oncol Hematol 59

      Pages: 15-26

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] 低酸素センサー-細胞は低酸素をいかに関知するか-2006

    • Author(s)
      広田喜一
    • Journal Title

      Anesthesia Network 10

      Pages: 11-5

    • Data Source
      KAKENHI-PROJECT-18390429
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines2005

    • Author(s)
      Takabuchi, S., K.Hirota, et al.
    • Journal Title

      J Anesth 19

      Pages: 263-265

    • NAID

      10016650659

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Hypoxia reduces constitutive and TNF-a-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells2005

    • Author(s)
      Li, X., Kimura, H., Hirota, K., Sugimoto, H., Yoshida, H
    • Journal Title

      Biochem Biophys Res Commun 335

      Pages: 1026-1034

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] KL-6, a human NUC1 mucin, promotes proliferation and survival of Lung fibroblasts2005

    • Author(s)
      Ohshimo, S., Yokoyama, A., Hattori, N., Ishikawa, N., Hirasawa, Y., Kohno, N
    • Journal Title

      Biochem.Biophys.Res.Commun 30

      Pages: 1845-1852

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Opioid receptor stimulation does not affect cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1 in cultured cell lines2005

    • Author(s)
      Takabuchi, S., Hirota, K., Oda, S., Nishi, K., Oda, T., Shingu, K., Adachi, T., Fukuda, K
    • Journal Title

      J Anesth 19

      Pages: 263-265

    • NAID

      10016650659

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 610-616

    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Reguiation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases2005

    • Author(s)
      Hirota, K., G.Semenza
    • Journal Title

      Biochem Biophys Res Commun 338

      Pages: 610-616

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 610-616

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 610-616

    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K., Hara, T., Hosoi, S., Hara, Y., Adachi, T.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J Aflesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 610-616

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K., Semenza, G.
    • Journal Title

      Biochem.Biophys.Res.Commun 338

      Pages: 610-606

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells2005

    • Author(s)
      Li, X., Kimura, H., Hirota, K., Kasuno, K., Torii, K., Okada, T., Kurooka, H., Yokota, Y., Yoshida, H
    • Journal Title

      Kidney Int 68

      Pages: 569-583

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] KL-6, a human NUC1 mucin, promotes proliferation and survival of Lung fibroblasts.2005

    • Author(s)
      Ohshimo, S., Yokoyama, A., Hattori, N., Ishikawa, N., Hirasawa, Y., Kohno, N.
    • Journal Title

      Biochem.Biophys.Res.Commun. 30

      Pages: 1845-1852

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 12005

    • Author(s)
      Nishi, K., Hirota, K., Takabuchi, S., Oda, S., Fukuda, K., Adachi, T., Shingu, T
    • Journal Title

      J Anesth 19

      Pages: 54-59

    • NAID

      10014428952

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 338

      Pages: 610-616

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] KL-6, a human NUC1 mucin, promotes proliferation and survival of Lung fibroblasts.2005

    • Author(s)
      Ohshimo, S., Yokoyama, A., Hattori, N., Ishikawa, N., Hirasawa, Y., Kohno, N.
    • Journal Title

      Biochem.Biophys.Res.Commun 30

      Pages: 1845-1852

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K., Hara, T., Hosoi, S., Hara, Y., Adachi, T.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J. Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases2005

    • Author(s)
      Hirota, K., Semenza, G
    • Journal Title

      Biochem Biophys Res Commun 338

      Pages: 610-616

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J. Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases2005

    • Author(s)
      Hirota, K., G.Semenza
    • Journal Title

      Biochem Biophys Res Commun 338

      Pages: 610-616

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Two cases of hyperkalemia after administration of hypertonic mannitol during craniotomy.2005

    • Author(s)
      Hirota, K., Hara, T., Hosoi, S., Hara, Y., Adachi, T.
    • Journal Title

      J.Anesth. 19

      Pages: 75-77

    • NAID

      10014429030

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K., Semenza, G.
    • Journal Title

      Biochem.Biophys.Res.Commun 338

      Pages: 610-606

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 610-616

    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Hypoxia reduces constitutive and TNF-alpha-induced expression of Monocyte chemoattractant protein-1 in human proximal renal tubular cells.2005

    • Author(s)
      Li, X., Kimura, H., Hirota, K., Sugimoto, H., Yoshida, H.
    • Journal Title

      Biochem.Biophys.Res.Commun. 335

      Pages: 1026-1034

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Hypoxia reduces constitutive and TNF-alpha-induced expression of Monocyte chemoattractant protein-1 in human proximal renal tubular cells.2005

    • Author(s)
      Li, X., Kimura, H., Hirota, K., Sugimoto, H., Yoshida, H.
    • Journal Title

      Biochem.Biophys.Res.Commun 335

      Pages: 1026-1034

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Hypoxia reduces constitutive and TNF-alpha-induced expression of Monocyte chemoattractant protein-1 in human proximal renal tubular cells.2005

    • Author(s)
      Li, X., Kimura, H., Hirota, K., Sugimoto, H., Yoshida, H.
    • Journal Title

      Biochem.Biophys.Res.Commun 335

      Pages: 1026-1034

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2005

    • Author(s)
      Hirota, K., Semenza, G.
    • Journal Title

      Biochem.Biophys.Res.Commun. 338

      Pages: 610-606

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 1.2005

    • Author(s)
      Nishi, K., K.Hirota, et al.
    • Journal Title

      J. Anesth 19

      Pages: 54-59

    • NAID

      10014428952

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] 低酸素応答の分子機構2004

    • Author(s)
      広田喜一
    • Journal Title

      Anesthesia 21 Century 6

      Pages: 34-38

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] 低酸素応答の分子機構2004

    • Author(s)
      広田 喜一
    • Journal Title

      Anesthesia 21 century 6

      Pages: 1014-1014

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Gene therapy for pulmonary diseases.2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Journal Title

      Frontiers in Immuno-gene Therapy

      Pages: 209-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.2004

    • Author(s)
      Hirota, K.
    • Journal Title

      Biochem Biophys Res Commun 338

      Pages: 610-616

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N. et al.
    • Journal Title

      American Journal of Pathology 164

      Pages: 1091-1098

    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 12004

    • Author(s)
      Nishi K, Hirota K他
    • Journal Title

      J.Anesth. 19

      Pages: 54-54

    • NAID

      10014428952

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Gene therapy for pulmonary diseases.2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Journal Title

      Frontiers in Immuno-gene Therapy

      Pages: 209-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N. et al.
    • Journal Title

      American Jpurnal of Pathology 164

      Pages: 1091-1098

    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway2004

    • Author(s)
      Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, T., Takabayashi, A., Adachi, T., Semenza, G.L., Fukuda, K
    • Journal Title

      Biochem Biophys Res Commun 324

      Pages: 417-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner2004

    • Author(s)
      Takabuchi S, Hirota, K 他
    • Journal Title

      FEBS Lett. 577

      Pages: 434-434

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling2004

    • Author(s)
      Kasuno, K., Takabuchi, S., Fukuda, K., Kizaka-Kondoh, S., Yodoi, J., Adachi, T., Semenza, G.L., Hirota, K
    • Journal Title

      J Biol Chem 279

      Pages: 2550-2558

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acety1choline receptor signaling.2004

    • Author(s)
      Hirota, K
    • Journal Title

      J Biol Chem 279

      Pages: 41521-41528

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling2004

    • Author(s)
      Hirota, K.
    • Journal Title

      J Biol Chem 279

      Pages: 41521-41528

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., Mizuno, S., Yoshida, Y., Chin, K., Mishima, M., Sisson, TH., Simon, RH., Nakamura, T., Miyake, M.
    • Journal Title

      Am.J.Pathol. 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., et al.
    • Journal Title

      Am. J. Pathol. 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway2004

    • Author(s)
      Takabuchi S, Hirota K 他
    • Journal Title

      Biochem.Biophys.Res.Commun. 324

      Pages: 417-417

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The effect of local anesthetics on the cellular hypoxia-induced gene responses mediated by hypoxia-inducible factor 12004

    • Author(s)
      Nishi, K, Hirota, K 他
    • Journal Title

      J.Anesth. 19

      Pages: 54-54

    • NAID

      10014428952

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling2004

    • Author(s)
      Hirota K, Fukada R 他
    • Journal Title

      J.Biol.Chem. 279

      Pages: 41521-41521

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Gene therapy for pulmonary diseases.2004

    • Author(s)
      Hattori, N., Miyake, M.
    • Journal Title

      Frontiers in Immuno-gene Therapy

      Pages: 209-225

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] HIF-1活性化調節因子FIH-1の機能解析2004

    • Author(s)
      広田 喜一
    • Journal Title

      分子細胞治療 3

      Pages: 96-96

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acethlcholine receptor signaling2004

    • Author(s)
      Hirota K, Fukuda R 他
    • Journal Title

      J.Biol.Chem. 279

      Pages: 41521-41521

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] HIF-1活性化調節因子FIH-1の機能解析2004

    • Author(s)
      広田 喜一
    • Journal Title

      分子細胞治療 3

      Pages: 96-96

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.2004

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Journal of Biological Chemistry 279

      Pages: 41521-41528

    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner2004

    • Author(s)
      Takabuchi, S., Hirota, K., Nishi, K., Oda, S., Oda, T., Shingu, T., Takabayashi, A., Adachi, T., Semenza, G.L., Fukuda, K
    • Journal Title

      FEBS Lett 577

      Pages: 434-438

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., et al.
    • Journal Title

      Am. J. Pathol. 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signalling.2004

    • Author(s)
      Hirota, K.
    • Journal Title

      J Biol Chem 279

      Pages: 41521-41528

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., Mizuno, S., Yoshida, Y., Chin, K., Mishima, M., Sisson, TH., Simon, RH., Nakamura, T., Miyake, M.
    • Journal Title

      Am.J.Pathol. 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., Mizuno, S., Yoshida, Y., Chin, K., Mishima, M., Sisson, TH., Simon, RH., Nakamura, T., Miyake, M.
    • Journal Title

      Am.J.Pathol. 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] 低酸素応答の分子機構2004

    • Author(s)
      広田 喜一
    • Journal Title

      Anesthesia 21 century 6

      Pages: 1014-1014

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The Plasminogen activation system reduces fibrosis in the lung by a Hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N., et al.
    • Journal Title

      Am. J. Pathol 164

      Pages: 1091-1098

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor-signaling.2004

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Journal of Biological Chemistry 279

      Pages: 41521-41528

    • Data Source
      KAKENHI-PROJECT-16591285
  • [Journal Article] The intravenous anesthetic propofol inhibits hypoxia-inducible factor 1 activity in an oxygen tension-dependent manner2004

    • Author(s)
      Takabuchi S, Hirota K他
    • Journal Title

      FEBS Lett. 577

      Pages: 434-434

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] The inhibitory effect of sodium nitroprusside on HIF-1 activation is not dependent on nitric oxide-soluble guanylyl cyclase pathway2004

    • Author(s)
      Takabuchi S, Hirota K他
    • Journal Title

      Biochem.Biophys.Res.Commun. 324

      Pages: 417-417

    • Data Source
      KAKENHI-PROJECT-15390481
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling2004

    • Author(s)
      Hirota, K, Fukuda, R., Takabuchi, S., Kizaka-Kondoh, S., Adachi, T., Fukuda, K., Semenza, G.L
    • Journal Title

      J Biol Chem 279

      Pages: 41521-41528

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism.2004

    • Author(s)
      Hattori, N. et al.
    • Journal Title

      American Journal of Pathology 164

      Pages: 1091-1098

    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.2004

    • Author(s)
      Hirota, K. et al.
    • Journal Title

      Journal of Biological Chemistry 279

      Pages: 41521-41528

    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] グルタミノリシス

    • Author(s)
      広田喜一
    • Journal Title

      Inがんと代謝

      Volume: (In Press)

    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Clinical significance of Aminopeptidase N in Non-Small Cell LungCancer.

    • Author(s)
      Tokuhara, T., Hattori, N., Ishida, H., Hirai, T., Higashiyama, M., Kodama, K., Miyake, M.
    • Journal Title

      Clin, Cancer, Res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390400
  • [Journal Article] Activation of hypoxia-inducible factor 1 during macrophage differentiation

    • Author(s)
      Oda, T.Hirota, K et al.
    • Journal Title

      Am J Physiol Cell Physiol, (In press)

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Regulation of Angiogenesis by Hypoxia-Inducible Factor 1.

    • Author(s)
      Hirota, K., G.Semenza
    • Journal Title

      Crit Rev Oncol Hematol (In press)

    • Data Source
      KAKENHI-PROJECT-16591576
  • [Journal Article] Clinical significance of Aminopeptidase N in Non-Small Cell LungCancer.

    • Author(s)
      Tokuhara, T., Hattori, N., Ishida, H., Hirai, T., Higashiyama, M., Kodama, K., Miyake, M
    • Journal Title

      Clin, Cancer, Res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591284
  • [Journal Article] Involvement of decreased hypoxiainducible factor 1 activity and resultant GI-S cell cycle transition in radioresistance of perinecrotic tumor cells

    • Author(s)
      Zuo, Y., Zhao, T., Itasaka, S., Zeng, L., Yoem, C., Hirota, K., Suzuki, K., Morinibu, A., Shinomiya, K., on, G., et al.
    • Journal Title

      Oncogene

      Volume: (In Press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Cancer cells that survive radiation therapy acquire HIF-l activity and translocate towards tumour blood vessels

    • Author(s)
      Harada, H., Inoue, M., Itasaka, S., Hirota, K., Morinibu, A., Shinomiya, K., Kadonosono, T., Kuchimaru, T., Yamada, S., Takahashi, Y., Murakami, A., Tani, T., Watanabe, H., Tanaka, T., Hirota, K., Inoue, M., et al
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 783-783

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Journal Article] Clinical significance of Aminopeptidase N in Non-Small Cell Lung Cancer.

    • Author(s)
      Tokuhara, T., Hattori, N., Ishida, H., Hirai, T., Higashiyama, M., Kodama, K., Miyake, M.
    • Journal Title

      Clin, Cancer, Res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591285
  • [Presentation] インターフェロンβ1-aはCD73の発現を制御しLPSによる肺血管透過性亢進を改善する2020

    • Author(s)
      松川志乃、甲斐慎一、松尾禎之、足立健彦、福田和彦、広田喜一
    • Organizer
      第47回日本集中治療医学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Presentation] ポリサルファイド(H2Sn)が細胞機能に与える影響の探究- Exploring the effects of polysulfide (H2Sn) on cell function2020

    • Author(s)
      広田 喜一
    • Organizer
      第93回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03776
  • [Presentation] 低酸素-低酸素誘導性因子(HIF)-炎症2019

    • Author(s)
      広田 喜一
    • Organizer
      第72回日本酸化ストレス学会学術集会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08874
  • [Presentation] マクロファージ活性化における代謝リプログラミングの分子機序2019

    • Author(s)
      松尾 禎之 広田 喜一
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K09339
  • [Presentation] 「Hypoxia and Beyond:HIF-1 から炎症・肺傷害へ」2019

    • Author(s)
      広田 喜一
    • Organizer
      第230回 原医研セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Presentation] ナノポアシークエンサーを用いた病原細菌の迅速同定を可能とするオンサイト解析パイプラインの確立2018

    • Author(s)
      松尾禎之、中川草、Kirill Kryukov、今西規、広田喜一
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] 炎症が惹起する代謝リプログラミングの分子機序の探求2018

    • Author(s)
      田畑凱光、松尾禎之、広田喜一
    • Organizer
      第16回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] 「酸素の問題点を考える」酸素による肺への影響:肺の硝子膜様変性、COPD、間質性肺炎2018

    • Author(s)
      広田喜一
    • Organizer
      第22回日本医療ガス学会 学術大会
    • Data Source
      KAKENHI-PROJECT-18K08877
  • [Presentation] サイブリッド細胞を用いたプロポフォール細胞毒性の検討2017

    • Author(s)
      角 千里、廣田 喜一、楠 宗矩、岡本 明久、西 憲一郎、松尾 禎之
    • Organizer
      第15回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] HIF-1-Mediated Suppression of Mitochondria Electron Transport Chain Function Confers _Resistance to Lidocaine-induced Cell Death2017

    • Author(s)
      SHINICHI KAI, Kiichi Hirota, Chisato Sumi, Akihisa Okamoto, Kenichiro Nishi, Munenori Kusunoki, Yoshiyuki Matsuo, Takehiko Adachi
    • Organizer
      American Society of Anesthesiology 2017 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10551
  • [Presentation] HIF-1-Mediated Suppression of Mitochondria Electron Transport Chain Function Confers Resistance to Lidocaine-induced Cell Death2017

    • Author(s)
      SHINICHI KAI, Kiichi Hirota, Chisato Sumi, Akihisa Okamoto, Kenichiro Nishi, Munenori Kusunoki, Yoshiyuki Matsuo, Takehiko Adachi
    • Organizer
      Anesthesiology 2017 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] サイブリッド細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2017

    • Author(s)
      角 千里, 広田 喜一, 楠 宗矩, 岡本 明久, 西 憲一郎, 松尾 禎之
    • Organizer
      第64回日本麻酔科学会学術集会
    • Place of Presentation
      神戸ポートピアホテル 神戸市
    • Year and Date
      2017-06-08
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] Propofol Induces Metabolic Reprogramming and Cell Death in a Mitochondria Electric Transport Chain-dependent Manner2017

    • Author(s)
      Kiichi Hirota Chisato Sumi Akihisa Okamoto, Munenori Kusunoki, Hiromasa Tanaka
    • Organizer
      Anesthesiology 2017 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] 小胞体内レドックスバランスの維持とストレス感知機構の解析:タンパク質のレドックス状態を指標としたストレスモニタリング2017

    • Author(s)
      松尾禎之、広田喜一
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] サイブリッド細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2017

    • Author(s)
      角 千里、広田 喜一、楠 宗矩、岡本 明久、西 憲一郎、松尾 禎之
    • Organizer
      第64回日本麻酔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] Propofol Induces Metabolic Reprogramming and Cell Death in a Mitochondria Electric Transport Chain-dependent Manner2017

    • Author(s)
      Kiichi Hirota Chisato Sumi Akihisa Okamoto, Munenori Kusunoki, Hiromasa Tanaka
    • Organizer
      Anesthesiology 2017 annual meeting
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] グルタチオンシステムと連動した小胞体酸化還元酵素の活性制御およびレドックス恒常性維持の分子機構解析2017

    • Author(s)
      松尾禎之、広田喜一
    • Organizer
      第15回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] HIF-1活性化はミトコンドリア電子伝達系を抑制してプロポフォールの細胞障害を軽減する2017

    • Author(s)
      田中宏昌,角 千里, 松尾 禎之, 広田 喜一
    • Organizer
      第15回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] HIF-1-Mediated Suppression of Mitochondria Electron Transport Chain Function Confers Resistance to Lidocaine-induced Cell Death2017

    • Author(s)
      SHINICHI KAI, Kiichi Hirota, Chisato Sumi, Akihisa Okamoto, Kenichiro Nishi, Munenori Kusunoki, Yoshiyuki Matsuo, Takehiko Adachi,
    • Organizer
      Anesthesiology 2017 annual meeting
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] 抗酸化物質のN-アセチルシステインはリドカインが誘導する活性酸素種産生や細胞死を抑制する2017

    • Author(s)
      岡本 明久、楠 宗矩、角 千里、西 憲一郎、松尾 禎之、広田 喜一
    • Organizer
      第64回日本麻酔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] サイブリッド細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2017

    • Author(s)
      角 千里、廣田 喜一、楠 宗矩、岡本 明久、西 憲一郎、松尾 禎之
    • Organizer
      第64回日本麻酔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] サイブリッド細胞を用いたプロポフォール細胞毒性の検討2017

    • Author(s)
      角 千里、廣田 喜一、楠 宗矩、岡本 明久、西 憲一郎、松尾 禎之
    • Organizer
      第15回がんとハイポキシア研究会
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] 2016 年アルバート・ラスカー基礎医学賞を記念して2016

    • Author(s)
      広田喜一
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル 岐阜市
    • Year and Date
      2016-11-05
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15577
  • [Presentation] transmitochondrial cybrids細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2016

    • Author(s)
      広田 喜一, 角 千里, 楠 宗矩, 岡本 明久, 田中 宏昌, 西 憲一郎 , 松尾 禎之
    • Organizer
      第23回日本静脈麻酔学会
    • Place of Presentation
      コラッセ福島 福島市
    • Year and Date
      2016-11-19
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] transmitochondrial cybrids細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2016

    • Author(s)
      広田 喜一、 角 千里、楠 宗矩 、岡本 明久 田中 宏昌, 西 憲一郎 , 松尾 禎之
    • Organizer
      第23回日本静脈麻酔学会
    • Place of Presentation
      コラッセ福島 福島市
    • Year and Date
      2016-11-19
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] 膜結合型酸化還元酵素TMX1のレドックス状態を指標とした小胞体ストレスのモニタリング2016

    • Author(s)
      松尾禎之、広田喜一
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] 2016 年アルバート・ラスカー基礎医学賞を記念して2016

    • Author(s)
      広田喜一
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル 岐阜市
    • Year and Date
      2016-11-05
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15682
  • [Presentation] transmitochondrial cybrids細胞を用いたプロポフォール細胞毒性の検討-プロポフォール注入症候群の病態生理学2016

    • Author(s)
      広田 喜一, 角 千里, 楠 宗矩, 岡本 明久 田中 宏昌, 西 憲一郎 , 松尾 禎之
    • Organizer
      第23回日本静脈麻酔学会
    • Place of Presentation
      コラッセふくしま(福島市)
    • Data Source
      KAKENHI-PROJECT-15K10551
  • [Presentation] 2016 年アルバート・ラスカー基礎医学賞を記念して2016

    • Author(s)
      広田 喜一
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル 岐阜市
    • Year and Date
      2016-11-05
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10974
  • [Presentation] 膜結合型酸化還元酵素 TMX1 のレドックス状態を指標とした小胞体ストレスのモニタリング2016

    • Author(s)
      松尾禎之、広田喜一
    • Organizer
      第14回がんとハイポキシア研究会
    • Place of Presentation
      岐阜グランドホテル(岐阜県岐阜市)
    • Year and Date
      2016-11-04
    • Data Source
      KAKENHI-PROJECT-16K10975
  • [Presentation] シンポジウム急性肺損傷・肺循環障害の分子病態低酸素と肺胞炎症2013

    • Author(s)
      広田喜一
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      東京都東京国際フォーラム
    • Year and Date
      2013-04-21
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 神経因性疼痛モデルラット脊髄における低酸素誘導性因子とその下流遺伝子の発現について2013

    • Author(s)
      松山智紀, 佐々木美佳, 天谷文昌, 広田喜一, 福田和彦
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-05-24
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 麻酔薬は敗血症時の視床下部における炎症性サイトカイン誘導を抑制する2013

    • Author(s)
      田中具治,広田喜一,甲斐慎一,松山智紀,福田和彦
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2013-05-24
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 麻酔薬は敗血症時の視床下部における炎症性サイトカイン誘導を抑制する。2013

    • Author(s)
      田中 具治、廣田 喜一、甲斐 慎一、松山 智紀、福田 和彦
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-25462432
  • [Presentation] 炎症・インフラマソームのレドックス制御とTXNIP/HIF-1システム2012

    • Author(s)
      広田喜一
    • Organizer
      第85回日本生化学会 シンポジウム:1S12 低酸素応答が制御する多彩な生命現象 -生理機能の解明から疾患に迫る
    • Place of Presentation
      福岡市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] ハイポキシア生物学ー酸素代謝からみる生命現象の方程式2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術集会
    • Place of Presentation
      札幌市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 炎症・インフラマソームのレドックス制御とTXNIP/HIF-1システム2012

    • Author(s)
      広田喜一
    • Organizer
      第85回日本生化学会 シンポジウム:1S12 低酸素応答が制御する多彩な生命現象 -生理機能の解明から疾患に迫る
    • Place of Presentation
      福岡市博多区国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592322
  • [Presentation] 「低酸素研究の10年」hypoxia-inducible factorの20年と5つの未解決問題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜市横浜開港会館
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] hypoxia-indicible factorの20年と5つの未解決問題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] ハイポキシア生物学ー酸素代謝からみる生命現象の方程式2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術集会
    • Place of Presentation
      札幌市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592336
  • [Presentation] イソフルランは、急性貧血により誘導される血中エリスロポエチンの上昇を抑制する2012

    • Author(s)
      甲斐慎一, 田中具治, 松山智紀, 大条紘樹, 広田喜一 ,福田和彦
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] ハイポキシア生物学ー酸素代謝からみる生命現象の方程式2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術集会
    • Place of Presentation
      札幌市北区北海道大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592322
  • [Presentation] 特別講演 ハイポキシア生物学ー酸素代謝から見る生命現象の方程式2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術総会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-11-16
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] マイクログリアの活性化と酸素環境が低酸素誘導性遺伝子発現と神経因性疼痛関連遺伝子発現に与える影響2012

    • Author(s)
      松山智紀,廣田喜一, 鈴木堅悟, 甲斐慎一, 大条紘樹, 福田和彦
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] Possible Involvement of Hypoxia-Inducible Factor 1 in Activation of Microglia and Subsequent Gene Expression Conferring Neuropathic Pain.2012

    • Author(s)
      Tomonori Matsuyama, Kiichi Hirota, Kengo Suzuki, Shinichi Kai, Kazuhiko Fukuda
    • Organizer
      2012 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] hypoxia-indicible factorの20年と5つの未解決問題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592336
  • [Presentation] 炎症の制御点としての低酸素誘導性因子2012

    • Author(s)
      広田喜一, 他
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸市(神戸ポートピアホテル・神戸国際会議場)
    • Year and Date
      2012-05-20
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] シンポジウム「生体ガスと臓器保護」-「硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する」2012

    • Author(s)
      広田喜一
    • Organizer
      第16回日本医療ガス学会学術大会・総会
    • Place of Presentation
      東京都東京ステーションコンファレンス
    • Year and Date
      2012-11-17
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] Odidative stress and Diseases2012

    • Author(s)
      Kiichi Hirota
    • Organizer
      33rd Naito Conference Oxygen Biology Hypoxia
    • Place of Presentation
      Sapporo
    • Year and Date
      2012-06-28
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] グリア細胞におけるLPS刺激によるIL-1beta遺伝子の発現は、全身麻酔薬により抑制される2012

    • Author(s)
      田中具治, 広田喜一, 甲斐慎一, 松山智紀, 福田和彦
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] マイクログリアにおける活性化刺激の低酸素応答に及ぼす影響の検討日本麻酔科学会2012

    • Author(s)
      松山智紀, 広田喜一, 鈴 堅悟, 甲斐慎一, 大条紘樹, 福田和彦
    • Organizer
      第59回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] hypoxia-indicible factorの20年と5つの未解決問題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜市中区横浜開港記念館
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592322
  • [Presentation] シンポジウム 「生体ガスと臓器保護」硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する2012

    • Author(s)
      広田喜一、甲斐慎一
    • Organizer
      第16回医療ガス学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2012-11-17
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] 炎症・インフラマソームのレドックス制御とTXNIP/HIF-1システム2012

    • Author(s)
      広田喜一
    • Organizer
      第85回日本生化学会 シンポジウム:1S12 低酸素応答が制御する多彩な生命現象 -生理機能の解明から疾患に迫る
    • Place of Presentation
      福岡市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] イソフルランは、急性貧血により誘導される血中エリスロポエチンの上昇を抑制する2012

    • Author(s)
      甲斐慎一、田中具治、松山智紀、大条紘樹、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会 第59回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] 周術期医学としてのハイポキシア生物学の探究2012

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-05-19
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] シンポジウム「低酸素研究の10年」hypoxia-inducible factorの20年と5つの未解決課題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回ガンとハイポキシア研究会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] TXNIP regulates the NLPR3 inflammatosome activity in a HIF-1- and thioredoxin-dependent manner in THP-1 macrophages2012

    • Author(s)
      Kiichi Hirota
    • Organizer
      33rd Naito Conference Oxygen Biology Hypoxia, Odidative stress and Diseases
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] シンポジウム「低酸素応答が制御する多彩な生命現象」炎症・インフラマソームのレドックス制御とTXNIP/HIF-1システム2012

    • Author(s)
      広田喜一
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] 周術期医学としてのハイポキシア生物学の探究2012

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸市(神戸ポートピアホテル・神戸国際会議場)
    • Year and Date
      2012-05-19
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] TXNIP regulates the NLPR3 inflammatosome activity in a HIF-1- and thioredoxin-dependent manner in THP-1 macrophages2012

    • Author(s)
      Kiichi Hirota
    • Organizer
      33rd Naito Conference Oxygen Biology Hypoxia, Odidative stress and Diseases
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] シンポジウム : 1S12低酸素応答が制御する多彩な生命現象-生理機能の解明から疾患に迫る-『炎症・インフラマソームのレドックス制御とTXNIP/HIF-1システム』2012

    • Author(s)
      広田喜一
    • Organizer
      第85回日本生化学会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 「ハイポキシア生物学ー酸素代謝からみる生命現象の方程式」2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術集会
    • Place of Presentation
      札幌市北海道大学学術交流会館
    • Year and Date
      2012-11-06
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] 炎症の制御点としての低酸素誘導性因子2012

    • Author(s)
      広田喜一, 他
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-05-20
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] hypoxia-indicible factorの20年と5つの未解決問題2012

    • Author(s)
      広田喜一
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659695
  • [Presentation] ハイポキシア生物学ー酸素代謝からみる生命現象の方程式2012

    • Author(s)
      広田喜一
    • Organizer
      第47回日本高気圧環境・潜水医学会学術集会
    • Place of Presentation
      札幌市
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in aμ-opioid receptor-dependent manner2011

    • Author(s)
      H. Daijo, K. Hirota, S. Kai1, T. Matsuyama, K. Suzuki T. Tanaka, T. Wakamatsu, K. Fukuda
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 静脈麻酔薬が膵b細胞のインスリン分泌に与える影響の検討2011

    • Author(s)
      鈴木堅悟, 広田喜一, 大条紘樹, 甲斐慎一, 松山智紀, 福田
    • Organizer
      第18回日本静脈麻酔学会
    • Year and Date
      2011-11-16
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] イソフルランは低酸素によるエリスロポエチンの上昇を抑制する2011

    • Author(s)
      甲斐慎一,田中具治、鈴木堅悟,大条鉱樹、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会 第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Hydrogen sulfide inhibits hypoxia-induced HIF-1 activation in a mitochondria-dependent manner2011

    • Author(s)
      Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Takuhiko Wakamatsu, Kazuhiko Fukuda, Kiichi Hirota
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一、大条鉱樹、甲斐慎一、鈴木堅悟,岸本俊、松山智紀
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] 周術期医学としてのハイポキシア生物学の探究2011

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] タバコ煙抽出物はヒト肺胞II型上皮細胞株(A549)において低酸素誘導性因子1(hypoxia-inducible factor 1:HIF-1)を活性化する2011

    • Author(s)
      大条紘樹、鈴木堅固,岸本俊、甲斐慎一、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会 第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Differential role of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions2011

    • Author(s)
      Kengo Suzuki, Satoshi Takabuchi, Hiroki Daijo, Shinichi Kai, Tomonori Matsuyama, Shin Kurosawa, Kazuhiko Fukuda, Kiichi Hirota
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] タバコ煙抽出物はヒト肺胞H型上皮細胞株(As4g)において低酸素誘導性因子1(hypoxia-inducible factor 1HIF-l1)を活性化する2011

    • Author(s)
      大条紘樹、鈴木堅固, 岸本俊、甲斐慎一、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 周術期医学としてのハイポキシア生物学の探求2011

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] イソフルランは低酸素によるエリスロポエチンの上昇を抑制する2011

    • Author(s)
      甲斐慎一, 田中具治、鈴木堅悟, 大条鉱樹、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] Isoflurane selectively inhibits the activation of hypoxia-inducible factor 2 and the induction of erythropoietin under hypoxic conditions in mouse brain2011

    • Author(s)
      Kiichi Hirota, Tomoharu Tanaka, Shinichi Kai, Tomohiro Koyama, Hiroki Daijo, Kengo Suzuki, Takehiko Adachi, Kazuhiko Fukuda
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] 学会賞記念講演 周術期医学としてのハイポキシア生物学の探求2011

    • Author(s)
      広田 喜一
    • Organizer
      第58回日本麻酔科学会学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] プロスタグランディンE1はHIF-1活性化、 VEGF発現を介して血管透過性を亢進させる2011

    • Author(s)
      鈴木堅悟、広田喜一、大条鉱樹、甲斐慎一、岸本俊、福田和彦
    • Organizer
      日本麻酔科学会 第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] タバコ煙抽出物はヒト肺胞 & 型上皮細胞株(A549)において低酸素誘導性因子1(hypoxia-inducible factor 1 : HIF-1)を活性化する2011

    • Author(s)
      大条紘樹、鈴木堅固,岸本俊、甲斐慎一、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一,大条紘樹,甲斐慎一,鈴木堅悟,岸本俊, 松山智紀
    • Organizer
      日本麻酔科学会 第58回学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Isoflurane selectively inhibits the activation of hypoxia-inducible factor 2 and the induction of erythropoietin under hypoxic conditions in mouse brain 2011 Annual Meeting2011

    • Author(s)
      Kiichi Hirota, Tomoharu Tanaka, Shinichi Kai, Tomohiro Koyama, Hiroki Daijo, Kengo Suzuki, Takehiko Adachi, Kazuhiko Fukuda
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      Chicago USA
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Isoflurane selectively inhibits the activation of hypoxia-inducible factor 2 and the induction of erythropoietin under hypoxic conditions in mouse brain2011

    • Author(s)
      Kiichi Hirota, Tomoharu Tanaka, Shinichi Kai, Tomohiro Koyama, Hiroki Daijo, Kengo Suzuki, Takehiko Adachi, Kazuhiko Fukuda
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Chicago
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] プロスタグランディンElはHIF-l1活性化、VEGF発現を介して血管透過性を充進させる2011

    • Author(s)
      鈴木堅悟、広田喜一、大条鉱樹、甲斐慎一、岸本俊、福田和彦
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 炎症の制御点としての低酸素誘導性因子2011

    • Author(s)
      広田喜一、大条鉱樹、甲斐慎一、鈴木堅悟, 岸本俊、松山智紀
    • Organizer
      日本麻酔科学会第58回学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 硫化水素が低酸素誘導性遺伝子応答に及ぼす影響2010

    • Author(s)
      甲斐 慎一、大条 紘樹、田中 具治、広田喜一、福田 和彦
    • Organizer
      日本麻酔科学会第57回学術総
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Effects of n-Propyl Gallate on Neuronal Survival after Forebrain Ischemia in Rats2010

    • Author(s)
      Masahiko Kawaguchi, Yasunobu Kawano, Hiichi Hirota, Hitoshi Furuya
    • Organizer
      The 38th Annual Meeting of Neurosurgical Anesthesia and Critical Care
    • Data Source
      KAKENHI-PROJECT-21591984
  • [Presentation] 硫化水素が低酸素誘導性遺伝子応答に及ぼす影響The effects of hydrogen sulfide on thecellular hypoxia-induced gene responses meditated by HIF-12010

    • Author(s)
      甲斐惧一、大条紘樹、田中具治、広田喜一、福田和彦
    • Organizer
      日本麻酔科学会第57回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] タバコ煙抽出物は低酸素誘導性因子1(hypoxia-induciblefactor1 : HIF-1)を活性化する2010

    • Author(s)
      大条紘樹, 広田喜一, 鈴木堅悟, 甲斐慎一, 岸本俊
    • Organizer
      第6回がんとハイポキシア研究会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-01-30
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 硫化水素が低酸素誘導性HIF-1活性化に及ぼす影響2010

    • Author(s)
      甲斐慎一, 鈴木堅悟, 広田喜一, 大条紘樹, 岸本俊
    • Organizer
      第6回がんとハイポキシア研究会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-01-30
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] 全身麻酔下では、低酸素による脳内エリスロポエチン発現誘導が抑制される2010

    • Author(s)
      田中 具治、広田 喜一、大条 紘樹、甲斐慎一、小山 智弘、福田 和彦
    • Organizer
      日本麻酔科学会第57回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] Effects of n-Propyl Gallate on Neuronal Survival after Forebrain Ischemia in Rats2010

    • Author(s)
      Masahiko Kawaguchi, Yasunobu Kawano, Hiichi Hirota, Hitoshi Furuya
    • Organizer
      American Society of Anesthesiologists, 2010 annual meeting
    • Data Source
      KAKENHI-PROJECT-21591984
  • [Presentation] フェンタニルはオピオイド受容体を介し、低酸素誘導性因子(hypoxia-induciblefactor 1 : HIF-1)を活性化するFentanyl induces hypoxiainducible factor 1 activation via opioid receptormediated signaling pathways2010

    • Author(s)
      大条紘樹、広田喜一、甲斐慎一、田中具治、福田和彦
    • Organizer
      日本麻酔科学会第57回学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-06-03
    • Data Source
      KAKENHI-PROJECT-22659283
  • [Presentation] ハイポキシア生物学2009

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第56回学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2009-08-17
    • Data Source
      KAKENHI-PROJECT-21591992
  • [Presentation] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular endothelial and smooth muscle cells2008

    • Author(s)
      Takehiko Adachi, Seiko Oda, Satoshi Takabuchi, Kenichiro Nishi, Kiichi Hirota
    • Organizer
      2008Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Orland
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Presentation] Macrophage migration inhibitory factor activates hypoxia-inducible factor 1 under hypoxic conditions in a p53-depenent manner2008

    • Author(s)
      Kiichi Hirota, Seiko Oda, Satoshi Takabuchi, Takuhiko Wakamatsu, Tomoharu Tanaka, Kazuhiko Fukuda
    • Organizer
      Keystone symposia Molecular, cellular, physiologica, and phathogenic responses to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-16
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Presentation] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular endothelial and smooth muscle cells2008

    • Author(s)
      Takehiko Adachi, Seiko Oda, Satoshi Takabuchi , Kenichiro Nishi, Kiichi Hirota
    • Organizer
      2008Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Orland
    • Data Source
      KAKENHI-PROJECT-19591827
  • [Presentation] Macrophage migration inhibitory factor activates hypoxia-inducible factor 1 under hypoxic conditions in a p53-depenent manner2008

    • Author(s)
      Kiichi Hirota, Seiko Oda, Satoshi Takabuchi, Takuhiko Wakamatsu, Tomoharu Tanaka, Kazuhiko Fukuda
    • Organizer
      Keystone symposia Molecular, cellular, physiologica, and phathogenic responses to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-16
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Presentation] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular endothelial and smooth muscle cells2008

    • Author(s)
      Takehiko Adachi, Seiko Oda, Satoshi Takabuchi , Kenichiro Nishi, Kiichi Hirota
    • Organizer
      2008Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Orland
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Presentation] Macrophage migration inhibitory factor activates hypoxia-inducible factor 1 under hypoxic conditions in a p53-depenent manner Keystone symposia Molecular2008

    • Author(s)
      Kiichi Hirota, Seiko Oda, Satoshi Takabuchi, Takuhiko Wakamatsu, Tomoharu Tanaka, Kazuhiko Fukuda
    • Organizer
      cellular, physiologica, and phathogenic responses to hypoxia
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2008-01-16
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Presentation] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2007

    • Author(s)
      広田 喜一, 他
    • Organizer
      第5回がんとハイポキシア研究会
    • Place of Presentation
      千葉県柏市
    • Year and Date
      2007-12-01
    • Data Source
      KAKENHI-PROJECT-19659396
  • [Presentation] Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner2007

    • Author(s)
      広田 喜一, 他
    • Organizer
      第5回がんとハイポキシア研究会
    • Place of Presentation
      千葉県 柏市
    • Year and Date
      2007-12-01
    • Data Source
      KAKENHI-PROJECT-19591789
  • [Presentation] 生体の低酸素応答の分子生物学 : 基礎から臨床応用まで2006

    • Author(s)
      広田喜一
    • Organizer
      日本麻酔科学会第53回学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2006-06-01
    • Data Source
      KAKENHI-PROJECT-18390429
  • [Presentation] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する

    • Author(s)
      広田喜一
    • Organizer
      第16回日本医療ガス学会学術集会
    • Place of Presentation
      東京都千代田区東京ステーションコンファレンス
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592322
  • [Presentation] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する

    • Author(s)
      広田喜一
    • Organizer
      第16回日本医療ガス学会学術集会
    • Place of Presentation
      東京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390298
  • [Presentation] 硫化水素はミトコンドリア依存的に低酸素誘導性遺伝子応答を調節する

    • Author(s)
      広田喜一
    • Organizer
      第16回日本医療ガス学会学術集会
    • Place of Presentation
      東京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659695
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    # of Collaborated Products: 13 results
  • 2.  MATSUO Yoshiyuki (50447926)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 39 results
  • 3.  MIYAKE Masayuki (90250076)
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    # of Collaborated Products: 16 results
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    # of Collaborated Products: 13 results
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    # of Collaborated Products: 6 results
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    # of Collaborated Products: 3 results
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    # of Collaborated Products: 1 results
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  • 39.  奥山 裕照 (50432373)
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  • 40.  竹永 啓三 (80260256)
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  • 41.  岩田 亮一 (60580446)
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  • 42.  松田 達志 (00286444)
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  • 43.  坊農 秀雅 (20364789)
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  • 44.  村田 宮彦 (50222435)
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  • 45.  ITASAKA Satoshi
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  • 46.  林 美樹夫
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  • 47.  クリュコフ キリル
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  • 48.  近藤 玄
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  • 49.  朴 将源
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