Yamashita Masakatsu 山下政克

… Alternative Names

Researcher Number	00311605
Other IDs
Affiliation (Current)	2019: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 愛媛大学, 医学系研究科, 教授 2016: 愛媛大学, 大学院・医学系研究科, 教授 2012 – 2016: 愛媛大学, 医学(系)研究科(研究院), 教授 2015: 愛媛大学, 大学院医学系研究科免疫学, 教授 2012: 愛媛大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Pathological medical chemistry / アレルギー / General medical chemistry Except Principal Investigator Immunology / Pathobiological dentistry/Dental radiology / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator アレルギー / GATA3 / 免疫 / Th2 / MLL / エピゲノム / メモリーTh2細胞 / 好酸球 / 炎症 / エフェクターTh2細胞 … More Except Principal Investigator アレルギー / Th2 / Bach2 / Th1 / Th2細胞 / TSLP / サイトカイン / Th2サイトカイン / NKT細胞 / トランスジェニックマウス / 免疫老化 / 転写因子 / アフィニティ樹脂 / 金属アレルギー / Rab / Gfi1 / 表皮ケラチノサイト / アレルギー疾患 / ニッケル / GATA-3 / アトピー性皮膚炎 / ノックアウトマウス Less

代謝―エピゲノムのクロストークによる慢性アレルギー性炎症の細胞社会形成Principal InvestigatorOngoing
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Ehime University
アフィニティ技術により同定した新規標的分子Rabを制御する抗アレルギー薬の創製Ongoing
- Principal Investigator
  
  所美雪
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Hyogo University of Health Sciences
Understanding the molecular mechanism of neo-self generation by cellular senescencePrincipal InvestigatorOngoing
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Regulatory mechanism of immune response through metabolic reprograming of T lymphocytesPrincipal InvestigatorOngoing
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Ehime University
Determination of helper T cell fate by amino acid metabolismPrincipal Investigator
- Principal Investigator
  
  Yamashita Masakatsu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Ehime University
Analysis of Bach2-mediated regulation of the chronic allergic inflammationPrincipal Investigator
- Principal Investigator
  
  Yamashita Masakatsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Ehime University
The mechanism of metal allergy construction by a transcription factor controlling immunocompetent cells and a surface reforming effect.
- Principal Investigator
  
  TAMAUCHI HIDEKAZU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Ehime Prefectural University of Health Science
核マトリクス変動を介したT細胞運命制御機構の解明Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
The study to clarify the molecular mechanism of fate decision of activated CD4 T cellsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Masakatsu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Ehime University
An investigation of the role of the transcription repressor Bach2 in CD4 T cell-mediated immune homeostasis
- Principal Investigator
  
  Kuwahara Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Ehime University
Regulation of T cell response and homeostasis by the TGFbeta/beta-catenin signalsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Masakatsu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University
  Kazusa DNA Research Institute
Sox型転写因子によるT細胞応答と炎症の制御Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kazusa DNA Research Institute
Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.
- Principal Investigator
  
  OMORI Miyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Women's Medical University
Wnt/β-Cateninシグナルを介したCD4T細胞自己応答性の制御Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Identification of memory Th2 stem cells that control allergic reactionsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Masakatsu
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Identification of transcription factors that control memory Th2 cell differentiationPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Masakatsu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
アレルギー疾患の病態形成におけるメモリーTh2細胞の役割と分化機構の解明Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
メモリーTh2細胞の機能とアレルギー疾患の病態形成における役割Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Research on the regulatory mechanisms of allergic inflammatory deseases by memory Th2 cells.Principal Investigator
- Principal Investigator
  
  YAMASHITA Masakatsu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  アレルギー
- Research Institution
  Chiba University
アレルギー発症を制御するヘルパーT細胞の機能分化に関する研究Principal Investigator
- Principal Investigator
  
  山下政克
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University

[Book] 免疫研究最前線20072008
- Author(s)
  山下政克
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20060003
[Book] 免疫研究最前線20072008
- Author(s)
  山下政克
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Menin plays a critical role in the regulation of the antigen-specific CD8+ T cell response upon Listeria infection2016
- Author(s)
  Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, and Yamashita M.
- Journal Title
  
  The Journal of immunology
  
  Volume: 197 Pages: 4079-4089
- DOI
  10.4049/jimmunol.1502295
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460579, KAKENHI-PROJECT-15K15155, KAKENHI-PROJECT-15K19133, KAKENHI-PROJECT-15K20149
[Journal Article] Bach2-Batf interractions control Th2-type immune response by regulating the IL-4 amplification loop2016
- Author(s)
  Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Pages: 12596-12596
- DOI
  10.1038/ncomms12596
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-15K15155, KAKENHI-PROJECT-15K19133, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K19158
[Journal Article] Gfi1, a transcriptional repressor, inhibits the induction of the T helper type1 programme in activated CD4 T cells2016
- Author(s)
  Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita
- Journal Title
  
  Immunology
  
  Volume: 147 Pages: 476-487
- DOI
  10.1111/imm.12580
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462851, KAKENHI-PROJECT-25860376, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-15K19133
[Journal Article] A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection2015
- Author(s)
  Maruyama Saho, Kanoh Makoto, Matsumoto Akira, Kuwahara Makoto, Yamashita Masakatsu, Asano Yoshihiro
- Journal Title
  
  International Immunology
  
  Volume: 27 Pages: 143-152
- DOI
  10.1093/intimm/dxu092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860376
[Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.2014
- Author(s)
  Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
- Journal Title
  
  Nature Communicationsature Communications
  
  Volume: 5 Pages: 1-12
- DOI
  10.1038/ncomms4555
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23390075, KAKENHI-PROJECT-24659475, KAKENHI-PUBLICLY-25118718, KAKENHI-PROJECT-25670232, KAKENHI-PROJECT-25860376, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-26460579
[Journal Article] Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis2014
- Author(s)
  Kuwahara M, Suzuki J ., Tofukuji S, Yamada T, Kanoh M, Matsumoto A, Maruyama S, Kometani K, Kurosaki T, Ohara O, Nakayama T and Yamashita, M
- Journal Title
  
  Nat. Commun
  
  Volume: 5 Pages: 3555-3555
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390075
[Journal Article] A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus2013
- Author(s)
  Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, Ohara O, Yamashita M
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0061785
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25118718, KAKENHI-PROJECT-25670232
[Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation2012
- Author(s)
  Kuwahara M, Yamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V and Nakayama T.
- Journal Title
  
  Nat. Immunol
  
  Volume: 13 Pages: 778-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390075
[Journal Article] Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFβ2012
- Author(s)
  Tofukuji S, Kuwahara M, Suzuki J, Ohara O, Nakayama T, and Yamashita M
- Journal Title
  
  J. Immunol
  
  Volume: 188 Pages: 4846-4857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390075
[Journal Article] Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.2010
- Author(s)
  Suzuki A., Iwamura C., Shinoda K., Tumes JD., Kimura YM., Hosokawa H., Endo Y., Horiuchi S,, Tokoyoda K., Koseki H., Yamashita M., Nakayama T.
- Journal Title
  
  J.Immunol. 184
  
  Pages: 4510-4520
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.2010
- Author(s)
  Onodera A., Yamashita M., Endo Y., Kuwahara M., Tofukuji S., Hosokawa H., Kanai A., Suzuki Y., Nakayama T.
- Journal Title
  
  J.Exp.Med. 207
  
  Pages: 2493-2596
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] The TCR-mediated signaling pathways that control the direction of helper T cell differentiation.2010
- Author(s)
  Nakayama T, Yamashita M
- Journal Title
  
  Semin.Immunol. 22
  
  Pages: 303-309
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.2009
- Author(s)
  Nakayama T., Yamashita M.
- Journal Title
  
  Semin.Immunol. 21
  
  Pages: 78-83
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmil regulates memory Th cell survival via repression of the Noxa gene2009
- Author(s)
  Yamashita, M.
- Journal Title
  
  Proceedings of the 2^<nd> European Congress of Immunology
  
  Pages: 157-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] CD69 controls the pathogenesis of allergic airway inflammation.2009
- Author(s)
  Miki HT., Hasegawa A., Iwamura C., Shinoda K, Tofukuji S., Watanabe Y., Hosokawa H., Motohashi S., Hashimoto K., Shirai M., Yamashita M., Nakayama T.
- Journal Title
  
  J.Immunol. 183
  
  Pages: 8203-8215
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmi1 regulates memory Th cell survival via repression of the Noxa gene2009
- Author(s)
  Yamashita, M.
- Journal Title
  
  Proceedings of the 2^<nd> European Congress of Immunology
  
  Pages: 157-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060003
[Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.2009
- Author(s)
  Kitajima M., Iwamura C., Miki HT., Shinoda K., Endo Y. Watanabe Y., Shinnakasu R., Hosokawa H., Hashimoto K., Motohashi S., Koseki H., Ohara O., Yamashita M., Nakayama T.
- Journal Title
  
  J.Immunol. 183
  
  Pages: 5388-5396
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Exp. Med. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Initiation and maintenance of Th2 cell identity. Truncated title : Regulation of Th2 responses.2008
- Author(s)
  Nakayama T., Yamashita M.
- Journal Title
  
  Curr.Opin.Immunol. 20
  
  Pages: 265-271
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Lymphoid enhancer factor (LEF1) interacts with GATA3 and controls its function in T helper type 2 cells.2008
- Author(s)
  Hossain MB., Hosokawa H., Hasegawa A., Watarai H., Taniguchi M., Yamashita M., Nakayama T.
- Journal Title
  
  Immunology 125
  
  Pages: 377-386
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness.2008
- Author(s)
  Hirahara K., Yamashita M., Iwamura C., Shinoda K., Hasegawa A., Yoshizawa H., Koseki H., Gejyo F., Nakayama T.
- Journal Title
  
  J.Allergy Clin.Immunol. 122
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 1109-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060003
[Journal Article] Progress in allergy signal research on mast cells : Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function.2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Pharmacol. Sci. 106
  
  Pages: 332-335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20060003
[Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Exp. Med (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Progress in allergy signal research on mast cells: Regulation of allergic airway inflammation through toll-like receptor 4-mediated modification of mast cell function.2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Pharmacol. Sci. 106
  
  Pages: 332-335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita M., Kuwahara M., Suzuki A., Hirahara K., Shinnakasu R., Hosokawa H., Hasegawa A., Motohashi S., Iwama A., Nakayama T.
- Journal Title
  
  J.Exp.Med. 205
  
  Pages: 1109-1120
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.2008
- Author(s)
  Shinnakasu R., Yamashita M., Kuwahara M., Hosokawa H., Hasegawa A., Motohashi S., Nakayama, T.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 28216-28335
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Exp. Med. 205
  
  Pages: 1109-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.2008
- Author(s)
  Ito T., Hasegawa A., Hosokawa H., Yamashita M., Motohashi S., Naka T., Okamoto Y., Fujita,Y., Ishii Y., Taniguchi M., Yano I., Nakayama T.
- Journal Title
  
  Int.Immunol. 20
  
  Pages: 849-860
- Data Source
  KAKENHI-PROJECT-20590485
[Journal Article] Schurri-2 regulates Th2-dependent airway inflammation and airway herresonsiveness2007
- Author(s)
  Yamashita, M
- Journal Title
  
  Int. Immunol 19
  
  Pages: 755-762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity (in press)
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity 24
  
  Pages: 611-622
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type2 cell responses.2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity 24
  
  Pages: 611-622
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.2006
- Author(s)
  Hasegawa, A, Miki, T., Hosokawa, H., Hossain, M.B., Shimizu, C., Hashimoto, K., Kimura, Y.M., Yamashita, M., Nakayama, T.
- Journal Title
  
  J.Immunol. 176
  
  Pages: 2546-2554
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Regulation of allergic airway inflammation through Toll like receptor 4-mediated modification of mast cell function.2006
- Author(s)
  Nigo, I.Y., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA. 103
  
  Pages: 2286-2291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cel responses.2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity. 24
  
  Pages: 611-622
- Data Source
  KAKENHI-PROJECT-17047007
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 celresponses.2006
- Author(s)
  Yamashita, M.
- Journal Title
  
  Immunity. 24
  
  Pages: 611-622
- Data Source
  KAKENHI-PROJECT-18590466
[Journal Article] Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.2005
- Author(s)
  Miyamoto, T., Kaneko, T., Yamashita, M., Tenda, Y., Inami, M., Suzuki, A., Ishii, S., Kimura, M., Hashimoto, K., Shimada, H., Yahata, H., Ochiai, T., Saito, I., DeGregori, J., Nakayama, T.
- Journal Title
  
  Int.Immunol. 17
  
  Pages: 759-768
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Ras-ERK MARK cascade regulates GATA3 stability and Th2 differentiation through ubiqutin-proteasome pathway.2005
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Biol. Chem. 280・33
  
  Pages: 29409-29419
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Regulation of Th2 cell differentiation by murine Schnurri-2.2005
- Author(s)
  Kimura, Y.M., Hosokawa, H., Yamashita, M., Watarai, H., Hasegawa, A., Iwamura, C., Taniguchi, M., Takagi, T., Ishii, S., Nakayama, T.
- Journal Title
  
  J.Exp.Med. 201
  
  Pages: 397-408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.2005
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 280・33
  
  Pages: 29409-29419
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Chromatin remodeling of the Th2 cytokine gene loci.2005
- Author(s)
  Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H., Shinnakasu, R.
- Journal Title
  
  The Innate Immune System : Strategies for Disease Control (International Congress Series 1285)(Elsevier)
  
  Pages: 216-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.2005
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 280・33
  
  Pages: 29409-29419
- Data Source
  KAKENHI-PROJECT-17047007
[Journal Article] Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway.2005
- Author(s)
  Yamashita, M., Shinnakasu, R., Asou, H., Kimura, M., Hasegawa, A., Hashimoto, K., Hatano, N., Ogata, M., Nakayama, T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 29409-29419
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 39454-39464
- Data Source
  KAKENHI-PROJECT-16043211
[Journal Article] Essential role of GATA3 for the maintenance Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Biol. Chem 279・26
  
  Pages: 26983-26990
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.2004
- Author(s)
  Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., Nakayama, T.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 39454-39464
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells.2004
- Author(s)
  Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., Nakayama, T.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 23123-23133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.2004
- Author(s)
  Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., Nakayama, T.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26983-26990
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Essential role of GATA3 for the maintenance of Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26983-26990
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.2004
- Author(s)
  Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M., Nakayama, T.
- Journal Title
  
  J.Immunol. 173
  
  Pages: 4967-4975
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J. Biol. Chem 279・38
  
  Pages: 39454-39464
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Essential role of GATA3 for the maintenance of Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 26983-26990
- Data Source
  KAKENHI-PROJECT-16043211
[Journal Article] Interleukin(IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.2004
- Author(s)
  Yamashita, M.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 39454-39464
- Data Source
  KAKENHI-PROJECT-16616003
[Journal Article] Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.
- Author(s)
  Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, Y.M., Hasegawa, A., Nakayama, T.
- Journal Title
  
  Immunity (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16616003
[Presentation] Metabolic regulation of T cell senescence by Menin2017
- Author(s)
  Masakatsu Yamashita
- Organizer
  KEYSTONE SYMPOSIA, Aging and Mechanisms of Aging-Related Disease
- Data Source
  KAKENHI-PUBLICLY-17H05794
[Presentation] T細胞老化の代謝・エピゲノム調節による加齢関連疾患の制御2017
- Author(s)
  山下政克，桑原誠，鈴木淳平，山田武司
- Organizer
  日本食品免疫学会2017年度大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05794
[Presentation] グルタミン代謝の抑制によるCD8+ T細胞の抗腫瘍活性の増強2017
- Author(s)
  名部彰吾、山田武司，鈴木淳平，山下政克，安川正貴
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04086
[Presentation] Meninはグルタミン代謝とヒストンH3K27脱メチル化調節を介してCD8 T細胞老化を制御する2017
- Author(s)
  鈴木淳平，桑原誠，山田武司，安川正貴、山下政克
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PUBLICLY-17H05794
[Presentation] The transcriptional repressor Bach2 regulates differentiation of pathogenic Th2 cells2017
- Author(s)
  Makoto Kuwahara, Masakatsu Yamashita
- Organizer
  The 46th Annual Meeting of The Japanese Society of Immunology
- Data Source
  KAKENHI-PROJECT-17H04086
[Presentation] Meninはグルタミン代謝とヒストンH3K27脱メチル化調節を介してCD8 T細胞老化を制御する2017
- Author(s)
  鈴木淳平，桑原誠，山田武司，安川正貴，山下政克
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04086
[Presentation] The transcriptional repressor Bach2 controls Th2-type immune response via interaction with Bach22017
- Author(s)
  Makoto Kuwahara, Tatsuya Sawasaki, Masakatsu Yamashita
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04086
[Presentation] The tumor suppressor men in epigenetically regulates CD8 T cell senescence via the modulation of glutamine metabolism2017
- Author(s)
  junpei Suzuki, Makoto Kuwahara, Takeshi Yamada, Masaki Yasukawa, Masakatsu Yamashita
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PUBLICLY-17H05794
[Presentation] The critical role of Bach2 in regulating type2 inflammation2017
- Author(s)
  Masakatsu Yamashita
- Organizer
  The 46th Annual Meeting of The Japanese Society of Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-17H04086
[Presentation] TCR-mediated activation of glutamine metabolism plays a critical role in regulating Th2 cell differentiation.2016
- Author(s)
  Kuwahara M., Inoue K., Imai Y., Yamashita M.
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2 interacts with Batf family transcription factors and inhibits Th2 cell differentiation.2016
- Author(s)
  Ochi M., Kuwahara M., Suzuki J., Matsumoto A., Kurosaki T., Yasukawa M., Sawasaki T., Yamashita M.
- Organizer
  International Conference of Immunology 2016
- Place of Presentation
  メルボルン、オーストラリア
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Bach2 controls the thpe-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] 腫瘍抑制因子 Menin は T 細胞の老化を制御する(Crucial role of Menin in the regulation of T cell immunosenescence)2015
- Author(s)
  桑原誠、鈴木淳平、山下政克
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会・合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 interacts with Batf family transcription factors and inhibits Th2 cell differentiation2015
- Author(s)
  OCHI Mizuki, KUWAHARA makoto, MATSUMOTO Akira, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Bach2 and Blimp1 cooperatively regulate Il1rl1 expression in CD4 T cells2015
- Author(s)
  IZUMOTO Maya, KUWAHARA Makoto, OCHI Mizuki, MATSUMOTO Akira, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Th2細胞分化には細胞内グルタミン代謝が必要である2015
- Author(s)
  塩入幹汰、桑原誠、山下政克
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪 (東京都港区)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 腫瘍抑制因子Meninは代謝調節を介してCD8 T細胞老化を制御する2015
- Author(s)
  鈴木淳平、桑原誠、山田武司、安川正貴、山下政克
- Organizer
  第３回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂 (石川県金沢市)
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2 controls the type-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 controls the thpe-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 転写制御因子Gfi1はTh1細胞分化とTh1型アレルギーを負に制御する2015
- Author(s)
  堀内美香, 鈴木淳平, 水木真純, 丸山砂穂, 玉内秀一, 安川正貴, 山下政克
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  東京（品川プリンスホテル）
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26462851
[Presentation] Menin plays an critical role in the survival of antigen-specific activated CD8+ T cells2015
- Author(s)
  YAMADA Takeshi, KANOH Makoto, MATSUMOTO Akira, YASUOKA Toshiaki, SUZUKI Junpei, MARUYAMA Saho, KUWAHARA Makoto, YASUKAWA Masaki, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Th2細胞分化には細胞内グルタミン代謝が必要である2015
- Author(s)
  塩入幹汰、桑原誠、山下政克
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪 (東京都港区)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] A tumor suppressor Menin controls CD8 T cell senescence by regulating energy metabolism2015
- Author(s)
  SUZUKI Junpei, KUWAHARA Makoto, MARUYAMA Saho, YAMADA Takeshi, YASUOKA Toshiaki, YASUKAWA Masaki, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Menin inhibits transcription programs that promote CD4 T cell senescence and Th1/Th2 differentiation2013
- Author(s)
  Kuwahara M, Yamada T, Nakayama T, Yamashita M.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PUBLICLY-25118718
[Presentation] Crutial role of Menin in the regulation of CD4 T cell terminal differentiation and senescence2013
- Author(s)
  Kuwahara M, Nakayama T, Yamashita M.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PUBLICLY-25118718
[Presentation] IL-4- or IL-13-mediated modification of structural molecules in murine and human epidermal keratinocyte. The American Association of Immunologists2013
- Author(s)
  Miyuki Omori-Miyake, Masakatsu Yamashita and Junji Yagi
- Organizer
  100th Annual Meeting
- Place of Presentation
  米国ハワイ州
- Data Source
  KAKENHI-PROJECT-22790475
[Presentation] Crutial role of Menin in the regulation of CD4 T cell terminal differentiation and senescence2013
- Author(s)
  Kuwahara M, Nakayama T, Yamashita M.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] Crucial role of Menin in the regulation of CD4 T cell terminal differentiation and senescence2013
- Author(s)
  Kuwahara M, Nakayama T, Yamashita M.
- Organizer
  Th 6th International Workshop of Kyoto T cell Conference
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-25670232
[Presentation] Menin inhibits transcription programs that promote CD4 T cell senescence and Th1/Th2 differentiation2013
- Author(s)
  Kuwahara M, Yamada T, Nakayama T, Yamashita M.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] Menin inhibits transcriptional programs that promote CD4 T cell senescence2013
- Author(s)
  Kuwahara M, Yamada T, Nakayama T, Yamashita M.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-25670232
[Presentation] HMG box 型転写因子Sox4はTGFβ刺激で誘導され, Th2細胞分化を抑制する2012
- Author(s)
  桑原誠,鈴木淳平,東福寺聡一,中山俊憲,小原収,山下政克
- Organizer
  第22回Kyoto T Cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] TGFβはIL-4をTh1細胞分化誘導因子へと変換する2012
- Author(s)
  東福寺聡一,桑原誠,鈴木淳平,中山俊憲,小原収,山下政克
- Organizer
  第22回Kyoto T Cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] Possible mechanisms of epidermal fragility in atopic dermatitis caused by IL-4 and IL-132012
- Author(s)
  大森深雪, 山下政克, 八木淳二
- Organizer
  第41回日本免疫学会総会学術総会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-22790475
[Presentation] Sox4 acts as a downstream target of TGFβ and suppresses Th2 type immune responses2011
- Author(s)
  KUWAHARA Makoto, IWAMURA Chiaki, SHINODA Kenta, TOFUKUJI Soichi, SUZUKI Junpei, NAKAYAMA Toshinori, YAMASHITA Masakatsu
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張市
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] Th2 細胞分化・機能の調節を介した気道炎症制御2011
- Author(s)
  山下政克,東福寺聡一,鈴木淳平,桑原誠
- Organizer
  第48回日本小児アレルギー学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] IL-4 and IL-13 modulate intermediate stage of epidermal keratinocyte differentiation2011
- Author(s)
  大森深雪, 山下政克, 八木淳二
- Organizer
  第40回日本免疫学会総会学術総会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-22790475
[Presentation] TGFβ converts IL-4 into a Th1 cell inducer2011
- Author(s)
  TOFUKUJI Soichi, KUWAHARA Makoto, SUZUKI Junpei, OHARA Osamu, NAKAYAMA Toshinori, YAMASHITA Masakatsu
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  幕張市
- Data Source
  KAKENHI-PROJECT-23390075
[Presentation] TGFβ存在下においてIL-4はTh1細胞分化を増強する2010
- Author(s)
  東福寺聡一、中山俊憲、山下政克
- Organizer
  第60回日本アレルギー学会秋期学術大会
- Place of Presentation
  東京
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] STAT6によって誘導されるポリコームとトライソラックスの置換反応2010
- Author(s)
  小野寺淳、山下政克、遠藤裕介、桑原誠、東福寺聡一、細川裕之、堀内周、渡邊友紀子、金井明教、鈴木譲、中山俊憲
- Organizer
  第20回Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Sox4はTGFβ刺激で誘導され、GATA3機能の阻害を介してTh2細胞分化を抑制する2010
- Author(s)
  桑原誠、山下政克、東福寺聡一、鈴木淳平、篠田健太、中山俊憲
- Organizer
  第20回Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2010-06-05
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Sox4によるTh1細胞分化制御の解析2010
- Author(s)
  東福寺聡一、桑原誠、鈴木淳平、小原収、中山俊憲、山下政克
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] 新規チオアミド系化合物SH-2251はTh2細胞分化に伴うIL-5遺伝子座のクロマチンリモデリングを阻害する2010
- Author(s)
  鈴木淳平、東福寺聡一、桑原誠、今村匡志、中山俊憲、小原収、加藤文法、山下政克
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Transcription factor MLL regulates IL-4-mediated anti-tumor response by tumor specific memory Th2 cells2009
- Author(s)
  Hosokawa H., Kitajima M., Ito T., Horiuchi S., Sasaki T., Nishimura T., Yamashita M., Nakayama T.
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Apolipoprotein A-II protects from ConcanavlinA-induced hepatitis through the inhibition of CD4 T cell activation.2009
- Author(s)
  山下潤二
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox4.2009
- Author(s)
  山下政克
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Apolipoprotein A-II protects from ConcanavalinA-induced hepatitis through the inhibition of CD4 T cell activation2009
- Author(s)
  山下潤二
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20060003
[Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox4.2009
- Author(s)
  山下政克
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox42009
- Author(s)
  山下政克
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20060003
[Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox42009
- Author(s)
  山下政克、桑原誠、東福寺聡一、中山俊憲
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Sox4 regulates GATA3-induced Th2 cell differentiation and Th2-dependent inflammatory responses2009
- Author(s)
  Kuwahara M., Yamashita M., Tofukuji S., Shinoda K., Onodera A., Suzuki J., Iwamura C., Nakayama T.
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Regulation of GATA3-induced immune responses by the transcription factor Sox42009
- Author(s)
  山下政克
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20060003
[Presentation] GfilはGATA3蛋白質の安定化を介してTh2細胞分化を制御する2008
- Author(s)
  山下政克
- Organizer
  第31回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を制御する/Bmil regulates memory CD4 Tcell survival via repression of the Noxa gene2008
- Author(s)
  Yamashita, M.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20060003
[Presentation] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の存在を制御する/Bmil regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita, M.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590485
[Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する2008
- Author(s)
  山下政克
- Organizer
  第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20060003
[Presentation] Bmil regulates memory CD4T cell survival via repression of Noxa2007
- Author(s)
  Yamashita, M.
- Organizer
  Biochemistry and Molecular Biology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] MLL-dependent maintenance of memory Th2 cell identity.2007
- Author(s)
  Yamashita, M.
- Organizer
  JSI-RCAIワークショップ2007
- Place of Presentation
  横浜
- Year and Date
  2007-03-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] BmilはNoxa遺伝子の発現調節を介してメモリーCD4 T細胞の生存を制御する2007
- Author(s)
  山下政克
- Organizer
  第30回日本分子生物学会年会第80回日本生化学学会大会合同大会 BMB2007
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmil2007
- Author(s)
  Yamashita, M.
- Organizer
  The 17th Kyoto T Cell Conference
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] BmilはNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を維持する/Bmil regulates memory Th cell survival via repression of the Noxagene.2007
- Author(s)
  Yamashita, M.
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  品川
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Bmil regulates memory Th cell survival via repression of the Noxa gene2007
- Author(s)
  Yamashita, M.
- Organizer
  The 37th Annual meeting of the Japanese Society for Immunology
- Place of Presentation
  Shinagawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] MLL-dependent maintenance of memory Th2 cell identity2007
- Author(s)
  Yamashita, M.
- Organizer
  JSI-RCAI Workshop 2007 Transcriptional factors and T lymphocytes development
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] BmilはNoxa遺伝子の発現調節を介してメモリーCD4T細胞の生存を制御する2007
- Author(s)
  山下政克
- Organizer
  第30回日本分子生物学会年会第80回日本生化学学会大会合同大会BMB2007
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] ポリコーム群遺伝子Bmi1によるメモリL-Th2細胞形成調節機構2007
- Author(s)
  山下政克
- Organizer
  第17回Kyoto T Cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] ポリコーム群遺伝子BmilによるメモリーTh2細胞形成調節機構2007
- Author(s)
  山下政克
- Organizer
  第17回Kyoto T Cell Conference
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity2006
- Author(s)
  Yamashita, M.
- Organizer
  The 36th Annual meeting of the Japanese Society for Immunology
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Epigenetic regulation of memory Th2 cell generation2006
- Author(s)
  Yamashita, M.
- Organizer
  Regulation of cellular memory by Polycomb super moleculer complexes
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Epigenetic regulation of memory Th2 cell generation2006
- Author(s)
  Yamashita, M.
- Organizer
  Fifth East Asian Biophysics Symposium & Forty-Fourth Annual meeting of the Biophysical Society of Japan
- Place of Presentation
  Okinawa
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Crucial role of MLL for the maintenance of Th2 cell identity.2006
- Author(s)
  Yamashita, M.
- Organizer
  CAI-JSI International Symposium on Immunology.
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Crucial role of MLL for the maintenance of memory Th 2 cell responses2006
- Author(s)
  Yamashita, M.
- Organizer
  The 16th Kyoto T Cell Conference
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] メモリーTh2細胞形成のエピジェネティック制御2006
- Author(s)
  山下政克
- Organizer
  蛋白質研究所セミナー/ポリコーム超分子複合体を介した細胞記憶の制御メカニズム
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function2006
- Author(s)
  Yamashita, M.
- Organizer
  The 36th Annual meeting of the Japanese Phermacological Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] TLR4を介した肥満細胞機能調節とアレルギー性気道炎症2006
- Author(s)
  山下政克
- Organizer
  第79回日本薬理学会シンポジウム
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Crucial role of MLL for the maintenance of memory Th2 cell identity.2006
- Author(s)
  Yamashita, M.
- Organizer
  第36回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] TLR4を介した肥満細胞機能とアレルギー性気道炎症の制御2006
- Author(s)
  山下政克
- Organizer
  生体機能と創薬シンポジウム2006
- Place of Presentation
  博多
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Crucial role of MLL for the maintenance of Th2 cell identity2006
- Author(s)
  Yamashita, M.
- Organizer
  CAI-JSI International Symposium on Immunology
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] ヒストンメチル基転移酵素MLLによるメモリーTh2反応の維持機構2006
- Author(s)
  山下政克
- Organizer
  第16回Kyoto T Cell Conference
- Place of Presentation
  京都
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function2006
- Author(s)
  Yamashita, M.
- Organizer
  Biofunction and Drug Discovery Symposium 2006
- Place of Presentation
  Hakata
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Epigenetic regulation of memory Th2 cell generation.2006
- Author(s)
  Yamashita, M.
- Organizer
  第5回東アジア生物物理学会シンポジウム合同会議
- Place of Presentation
  沖縄
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590466
[Presentation] Bach2-Blimp1 axis plays an important role in the regulation of allergic airway inflammation
- Author(s)
  Izumoto M, Kuwahara M, Kiyoi T, Shinoda K, Nakayama T, Kurosaki T and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Crucial role of Menin in the epigenetic regulation of Satb1 expression in CD8 T cells.
- Author(s)
  Suzuki J, Yamada T, Yasuoka T, Ochi M, Kuwahara M, Yasukawa M and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PUBLICLY-25118718
[Presentation] Bach2 controls Th2 cell-mediated immune responses through regulation of glutaminolysis
- Author(s)
  Kuwahara M, Ochi M, Kiyoi T, Kurosaki T and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 腫瘍抑制因子MeninによるCD4T細胞機能の制御
- Author(s)
  桑原　誠、山下　政克
- Organizer
  第12回　四国免疫フォーラム
- Place of Presentation
  徳島文理大学香川キャンパス、香川
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Th2細胞分化におけるグルタミン代謝の役割とBach2による制御
- Author(s)
  山下政克
- Organizer
  第2回がんと代謝研究会
- Place of Presentation
  東京理科大学葛飾キャンパス
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Gfil negatively regulates murine Nickel allergy through inhibition of Th1 differentiation
- Author(s)
  Maruyama S, Mizuki M, Suzuki J, Kuwahara M, Zhu J, Tamauchi H and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PUBLICLY-25118718
[Presentation] Menin plays a critical role in the expansion and maintenance of antigen-specific CD8+ T cells upon infection.
- Author(s)
  Yamada T, Kano M, Matsumoto A, Yasuoka T, Suzuki J, Kuwahara M and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25670232
[Presentation] 転写調節因子Bach2によるヘルパーT細胞サブセット分子とアレルギー性気道炎症の制御
- Author(s)
  桑原誠、山下政克
- Organizer
  第24回 Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Crucial role of Menin in the regulation of CD4 T cell senescence
- Author(s)
  Makoto Kuwahara, Toshinori Nakayama, Masakatsu Yamashita
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  MiCo-Milano Congressi, Milan, Italy
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 controls Th2 cell-mediated immune responses through regulation of glutaminolysis
- Author(s)
  Kuwahara Makoto, Ochi Mizuki, Kiyoi Takeshi, Kurosaki Tomohiro, Yamashita Masakatsu
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Gfi negatively regulates murine NIckel allergy through inihibition og Th1 differentiation
- Author(s)
  MARUYAMA SAHO, MIAUKI MASUMI, KUWAHARA MAKOTO, ZHU JINFANG, TAMAUCHI HIDEKAZU, YAMASHITA MASAKATSU
- Organizer
  Japanese Society for Immunology (JSI)
- Place of Presentation
  Koyoto International Conference Center
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26462851
[Presentation] Menin inhibits transcriptional programs that promote CD4 T cell senescence and Th1/Th2 differentiation
- Author(s)
  Makoto Kuwahara, Takeshi Yamada, Toshinori Nakayama, Masakatsu Yamashita
- Organizer
  第42回　日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Crucial role of Menin in the epigenetic regulation of Satb1 expression in CD8 T cells.
- Author(s)
  Suzuki J, Yamada T, Yasuoka T, Ochi M, Kuwahara M, Yasukawa M and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25670232
[Presentation] 転写抑制因子Gfi-1ノックアウトマウスを用いた金属アレルギーの発症機序　ーGfi-1は、Th1細胞分化を負に制御するー
- Author(s)
  水木真帆、丸山砂穂、玉内秀一、山下政克
- Organizer
  文部科学省GP/基礎GP 医学・医療の高度化の基礎を担う基礎研究医の陽性　第15回医科学研究発表会
- Place of Presentation
  愛媛大学医学部
- Year and Date
  2014-09-18 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26462851

1. KUWAHARA Makoto (00568214)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. TAMAUCHI Hidekazu (60188414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. OMORI Miyuki (30462667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. OHARA Osamu (20370926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 小茂鳥潤 (30225586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 所美雪 (60714897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中明人 (30454789)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUZUKI Junpei

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. Yasukawa Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
10. 黒崎知博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 丸山砂穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 山田武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 安岡稔晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 澤崎達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yamashita Masakatsu 山下 政克

YAMASHITA Masakatsu 山下 政克

山下 政克 ヤマシタ マサカツ

Research Projects

Research Products

Co-Researchers

代謝―エピゲノムのクロストークによる慢性アレルギー性炎症の細胞社会形成Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Institution

アフィニティ技術により同定した新規標的分子Rabを制御する抗アレルギー薬の創製Ongoing

Principal Investigator

Project Period (FY)

Research Category

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Understanding the molecular mechanism of neo-self generation by cellular senescencePrincipal InvestigatorOngoing

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Regulatory mechanism of immune response through metabolic reprograming of T lymphocytesPrincipal InvestigatorOngoing

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Determination of helper T cell fate by amino acid metabolismPrincipal Investigator

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Analysis of Bach2-mediated regulation of the chronic allergic inflammationPrincipal Investigator

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The mechanism of metal allergy construction by a transcription factor controlling immunocompetent cells and a surface reforming effect.

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核マトリクス変動を介したT細胞運命制御機構の解明Principal Investigator

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The study to clarify the molecular mechanism of fate decision of activated CD4 T cellsPrincipal Investigator

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An investigation of the role of the transcription repressor Bach2 in CD4 T cell-mediated immune homeostasis

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Regulation of T cell response and homeostasis by the TGFbeta/beta-catenin signalsPrincipal Investigator

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Sox型転写因子によるT細胞応答と炎症の制御Principal Investigator

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Effects of interactions of TSLP and Th2 cells on development of symptoms of atopic dermatitis.

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Yamashita Masakatsu 山下政克

YAMASHITA Masakatsu 山下政克

山下政克ヤマシタマサカツ