OSAWA Haruhiko 大澤春彦

… Alternative Names

Researcher Number	90294800
Other IDs
External Links
Affiliation (Current)	2022: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 愛媛大学, 医学系研究科, 教授 2011 – 2016: 愛媛大学, 医学(系)研究科(研究院), 教授 2015: 愛媛大学, 大学院医学研究科, 教授 2015: 愛媛大学, 大学院医学系研究科, 教授 2013: 愛媛大学, 大学院医学系研究科, 教授 … More
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics / Biological Sciences / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Laboratory medicine / Metabolomics / Metabolomics / Biological Sciences / Basic Section 52010:General internal medicine-related / Public health/Health science … More
Keywords	Principal Investigator インスリン抵抗性 / 遺伝子発現 / レジスチン / SNP / 2型糖尿病 / 脂肪細胞 / エピジェネティクス / 遺伝子 / 糖尿病 / 転写因子 … More Except Principal Investigator 糖尿病 / SNP / レジスチン / インスリン / インスリン抵抗性 / PDE3B / 遺伝子 / 環境因子 / ハプロタイプ / 脂肪細胞 / 2型糖尿病 / 動脈硬化 / resistin / HLA / GAD抗体 / 自己炎症疾患 / インフラマソーム / 家族性地中海熱 / Akt / Insulin / 感受性遺伝子 / 多型 / insulin resistance / 相互作用 / 14-3-3β / insulin / Diabetes / GLUT4 / 生活習慣病 / KCNQ1 / GWAS / 候補遺伝子 / 予測モデル / 遺伝因子 / ゲノムワイド関連解析 / KCNQ1遺伝子 / cumulative risk / 関連解析 / TCF7L2遺伝子 / HHEX遺伝子 / CPT1A / HNF4α / AMPK / TCF7L2 / UCP2 / Resistin / CYP2C9 / UCP1 / hepatic lipid content / adiponectin receptors / HNF-4α / AMPキナーゼ / ベータセルリン / ヒトレジスチン / 転写調節 / プロモーター / インスリン応答性エレメント / 長期縦断疫学研究 / ゲノム / 動脈硬化性疾患 / 長期縦断研究 / モノクローナル抗体 / ELISA / モノクロナール抗体 / DNA メチル化 / 遺伝子発現 / DNAメチル化 / 免疫 / マクロファージ / M1/M2 / Th1 / SNPs / DNA array / 分類 / 無細胞蛋白質合成システム / クリオピリン関連周期熱症候群 / トルコ / トルコ共和国 / 1型糖尿病 / 1型糖尿病関連因子 / microRNA / アデノウイルス / PI3-K / PKB / PKCλ / adenovirus / PI 3-K / アディポサイトカイン / 転写 / 転写因子 / 疾患感受性 / PDE / diabetes / susceptibility genes / polymorphism / adipocytokine / transcription / phosphodiesterase 3B / セリン燐酸化 / 14-3-3 β / Phosbodiesterase 3B / Interaction / Serine phosphorylation / Adipocytes / Susceptibility gene / Polymorphisms / Haplotype / インスリン作用 / グルコース輸送 / 糖輸送担体 / レトロウィルス発現系 / insulin action / glucose transport / glucose transporter / retrovirus expression system / 網膜症 / 筋繊維芽細胞 / 筋線維芽細胞 / 糖尿病網膜症 / 平滑筋様細胞 / 形質転換 / Retinopathy / Myofibroblasts / 燐酸化 / adipocytes / phosphorylation / interaction / 頚動脈壁肥厚 / 睡眠の質 / 睡眠呼吸障害 / 健診時血圧 / 起床時血圧 / 就寝時血圧 / 血圧 / 頸動脈肥厚 / 高感度ELISA / 一塩基多型(SNP) / メチル化 / 糖尿病新規発症 / 遺伝学 / インフラマソーム病 / コンパニオン診断 / 難病 / 一酸化炭素 / メチルアルギニン / AGXT2遺伝子 / 高血圧 / 認知症 / 一酸化窒素 / AGXT2 / DDAH1 / 遺伝子関連解析 / 集団ベース研究 / 精神神経疾患 / アミノ基転移酵素 / 多型解析 / DDAH / 集団ベース解析 / モデルマウス / nitric oxide / population based study / mental disorders / 一塩基多型 / 社会心理学的因子 / コホート研究 / 循環器疾患 / オンライン診療 / 超高感度ELISA / 在宅 / 心不全スクリーニング / 心不全 / NTproBNP Less

社会心理学的因子を介した2型糖尿病・循環器疾患発症に関するコホート研究
- Principal Investigator
  
  斉藤功
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Oita University
オンライン診療をふまえた超高感度ELISAによる在宅採取サンプルを用いた臨床検査
- Principal Investigator
  
  高田康徳
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Ehime University
レジスチン遺伝子発現制御機構におけるプロモーターSNP配列特異的効果の統合的解明Principal Investigator
- Principal Investigator
  
  大澤春彦
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Ehime University
2型糖尿病原因遺伝子レジスチンを標的とした遺伝子環境因子相互作用メカニズムの解明
- Principal Investigator
  
  川村良一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Ehime University
Population based study of mental disorders by nitric oxide system variants.
- Principal Investigator
  
  Ueno Shuichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Ehime University
The influence of resistin SNPs on glucose intolerance in general population
- Principal Investigator
  
  Takata Yasunori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Ehime University
Acceleration of the definition of "inflammasome disease" based on molecular mechanism of diseases
- Principal Investigator
  
  MASUMOTO Junya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Internal medicine of the bio-information integration and related fields
- Research Institution
  Ehime University
Classification of diabetes based on high sensitivity anti-GAD antibody and HLA
- Principal Investigator
  
  Hiroshi Onuma
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tokyo Women's Medical University
  Ehime University
Regulation of human resistin gene expression by SNPs determining epigenetics and environmental factorsPrincipal Investigator
- Principal Investigator
  
  Osawa Haruhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
A prospective study in order to identify inflammatory attack triggers in autoinflammatory diseases
- Principal Investigator
  
  Masumoto Junya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Ehime University
A comparative study of intrinsic factor activating inflammasome between Turkey and Japan
- Principal Investigator
  
  Masumoto Junya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  Ehime University
Elucidation of the mechanisms of the association between resistin and type 1 diabetes. – The establishment of novel laboratory procedure for prediction of insulin dependent diabetes mellitus -
- Principal Investigator
  
  TAKATA YASUNORI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Ehime University
HLA and classification of diabetes
- Principal Investigator
  
  Onuma Hiroshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Ehime University
Regulation of the human resistin gene expression by SNPs, epigenetics, and environmental factorsPrincipal Investigator
- Principal Investigator
  
  OSAWA HARUHIKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Impact of Sleep Disordered Breathing and Home and Office Blood Pressure on Carotid Arterial Wall Thickness: the Toon Health Study
- Principal Investigator
  
  Eguchi Eri
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Okayama University
  Ehime University
The influence of resistin related immune-system on the pathophysiology of diabetes
- Principal Investigator
  
  TAKATA Yasunori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Ehime University
Establishment of anti human monoclonal antibody clones using cell-free protein translation system and development of automatic measurement system of human resistin.
- Principal Investigator
  
  NISHIDA Wataru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Ehime University
Regulation of human resistin gene expression integrating the DNA methylation
- Principal Investigator
  
  ONUMA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Epigenetic models of insulin resistance targeting the human resistin genePrincipal Investigator
- Principal Investigator
  
  OSAWA Haruhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Longitudinal genetic epidemiological study for cardiovascular diseases based on Japanese general population participated in medical check-up process of Ehime University Anti-aging doc.
- Principal Investigator
  
  TABARA Yasuharu
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Public health/Health science
- Research Institution
  Kyoto University
  Ehime University
Application of Resistin SNP to Order-made Medicine of Metabolic SyndromePrincipal Investigator
- Principal Investigator
  
  OSAWA Haruhiko, 牧野英一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Regulation of human resistin gene expression by insulin through functional SNP
- Principal Investigator
  
  ONUMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Identification and clinical application of susceptibility genes for diabetes mellitus.
- Principal Investigator
  
  KASUGA Masato
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Identification of transcription activators of resistin gene with type 2 diabetes susceptibility promoter SNPPrincipal Investigator
- Principal Investigator
  
  OSAWA Haruhiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
The cloning and characterization of the 50 kDa protein which is associated with PDE3B and phosphorylated by insulin
- Principal Investigator
  
  MAKINO Hideichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
脂肪細胞褐色化転換転写因子"FOXC2"による脂肪細胞形質決定因子の体系的同定Principal Investigator
- Principal Investigator
  
  大澤春彦
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Identification of novel factors regulating "insulin-responsiveness" by retrovirus expression system.
- Principal Investigator
  
  HASHIRAMOTO Mitsuru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  EHIME UNIVERSITY
Molecular mechanism of proliferation of myofibroblasts in diabetic retinopathy
- Principal Investigator
  
  NISHIDA Wataru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
The analysis of a newly identified molecule which interacts with phosphodiesterase3B insulin-dependently
- Principal Investigator
  
  ONUMA Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Whole genome association study on type 2 diabetes susceptibility genes using microsatellite markers and DNA pool
- Principal Investigator
  
  MAKINO Hideichi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Identification of novel adipocyte-specific factors regulating PDE3B gene transcription different from PPAR_γPrincipal Investigator
- Principal Investigator
  
  OSAWA Haruhiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University
Identification of diabetes-related genes
- Principal Investigator
  
  HIDEICHI Hideichi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Analysis of insulin-induced PDE kinase activation by gene transfer using adenovirus vector
- Principal Investigator
  
  MAKINO Hideichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University School of Medicine
Identification of Activating Factors for Phosphodiesterase 3B Gene TranscriptionPrincipal Investigator
- Principal Investigator
  
  HARUHIKO Osawa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Ehime University School of Medicine

[Book] 検査ONE POINTインスリン抵抗性の評価検査2012
- Author(s)
  西田亙, 大澤春彦
- Publisher
  SRL宝函
- Data Source
  KAKENHI-PROJECT-22590530
[Book] 血糖自己測定の指導法,糖尿病最新の治療2010～20122010
- Author(s)
  西田亙, 大澤春彦
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22590530
[Book] 血糖自己測定の指導法, 糖尿病最新の治療2010
- Author(s)
  西田亙, 大澤春彦
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22590530
[Book] 新時代の糖尿病学22008
- Author(s)
  大澤春彦、牧野英一
- Total Pages
  655
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-17019047
[Book] 糖尿病学基礎と臨床, レジスチン2007
- Author(s)
  大澤春彦, 他
- Total Pages
  1400
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Simple and non-invasive screening method for diabetes based on myoinositol levels in urine samples collected at home2020
- Author(s)
  Takakado Misaki、Takata Yasunori、Yamagata Fumio、Yaguchi Michiko、Hiasa Go、Sato Sumiko、Funada Jun-ichi、Kawazu Shoji、Osawa Haruhiko
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 8
- DOI
  10.1136/bmjdrc-2019-000984
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08985
[Journal Article] Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study2019
- Author(s)
  Higashioka Mayu、Hirakawa Yoichiro、Kawamura Ryoichi、Honda Takanori、Hata Jun、Yoshida Daigo、Takata Yasunori、Kitazono Takanari、Osawa Haruhiko、Ninomiya Toshiharu
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 11 Pages: 482-489
- DOI
  10.1111/jdi.13129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17925, KAKENHI-PROJECT-17K08985, KAKENHI-PROJECT-17K09113
[Journal Article] Variants in the BACH2 and CLEC16A gene might be associated with susceptibility to insulin‐triggered type?1 diabetes2019
- Author(s)
  Onuma Hiroshi、Kawamura Ryoichi、Tabara Yasuharu、Yamashita Masakatsu、Ohashi Jun、Kawasaki Eiji、Imagawa Akihisa、Yamada Yuya、Chujo Daisuke、Takahashi Kenji、Suehiro Tadashi、Takata Yasunori、Osawa Haruhiko、Makino Hideichi
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10 Pages: 1447-1453
- DOI
  10.1111/jdi.13057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H05036, KAKENHI-PROJECT-17K08985
[Journal Article] An inverse association between serum resistin levels and n-3 poly, unsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study.2018
- Author(s)
  Noumi Y. Kawamura R. Tabara Y. Maruyama K. Takata Y. Nishida W. Okamoto A. Nishimiya T. Onuma H. Saito I. Tanigawa T. Osawa H.
- Journal Title
  
  Clin Endocrinol (Oxf)
  
  Volume: 88 Pages: 51-57
- DOI
  10.1111/cen.13500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-17K08985, KAKENHI-PROJECT-16K09754
[Journal Article] Association between heart rate variability and home blood pressure: the Toon Health Study.2018
- Author(s)
  Saito I, Takata Y, Maruyama K, Eguchi E, Kato T, Shirahama R, Tomooka K, Kawamura R, Sano M, Tabara Y, Osawa H, Tanigawa T.
- Journal Title
  
  American Journal of Hypertension
  
  Volume: 31 Pages: 1120-1126
- DOI
  10.1093/ajh/hpy100
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08985, KAKENHI-PROJECT-16K09072
[Journal Article] IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans' islets, directly initiates NLRP3 inflammasome activation.2018
- Author(s)
  Morikawa S, Kaneko N, Okumura C, Taguchi H, Kurata M, Yamamoto T, Osawa H, Nakanishi A, Zako T, Masumoto J.
- Journal Title
  
  International Journal of Immunopathology and Pharmacology
  
  Volume: 32 Pages: 1-10
- DOI
  10.1177/2058738418788749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04656, KAKENHI-PROJECT-17K19685, KAKENHI-PROJECT-18H00464
[Journal Article] DIHSと劇症1型糖尿病2016
- Author(s)
  大沼裕, 牧野英一, 大澤春彦
- Journal Title
  
  日本体質医学会雑誌
  
  Volume: 78 Pages: 1-6
- NAID
  40020795429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460690
[Journal Article] 1型糖尿病発症と薬剤　DIHSと1型糖尿病2015
- Author(s)
  牧野英一, 大沼裕, 大澤春彦
- Journal Title
  
  月刊糖尿病
  
  Volume: 7 Pages: 39-47
- Data Source
  KAKENHI-PROJECT-25460690
[Journal Article] Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP Toon Health Study.2013
- Author(s)
  Tabara Y, Igase M, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Okada Y, Hitsumoto S, Onuma H, Nagai T, Takata Y, Uetani E, Takita R, Kido T, Ochi N, Osawa H, Tanigawa T, Miki T
- Journal Title
  
  Clin Hemorheol Microcirc.
  
  Volume: in press Pages: 297-311
- DOI
  10.3233/ch-2012-1634
- NAID
  120005366009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185, KAKENHI-PROJECT-23390188, KAKENHI-PROJECT-23590796, KAKENHI-PROJECT-23659382, KAKENHI-PROJECT-25670353
[Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study2012
- Author(s)
  Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
- Journal Title
  
  J Hypertens
  
  Volume: 29 Pages: 1948-1954
- Data Source
  KAKENHI-PROJECT-22590530
[Journal Article] 血中レジスチン規定因子としての SNP の意義2012
- Author(s)
  大沼裕, 大澤春彦
- Journal Title
  
  愛媛医学
  
  Volume: 31巻 4号 Pages: 161-165
- Data Source
  KAKENHI-PROJECT-22590985
[Journal Article] 検査ONE POINTインスリン抵抗性の評価検査2012
- Author(s)
  西田亙, 大澤春彦
- Journal Title
  
  SRL宝函
  
  Volume: 32 Pages: 43-46
- Data Source
  KAKENHI-PROJECT-22590530
[Journal Article] 遺伝子-遺伝子相互作用2011
- Author(s)
  大沼裕、大澤春彦
- Journal Title
  
  プラクティス
  
  Volume: 別冊 Pages: 134-136
- Data Source
  KAKENHI-PROJECT-22590985
[Journal Article] 生活習慣病における遺伝因子-2型糖尿病を中心に-2011
- Author(s)
  大澤春彦
- Journal Title
  
  日本体質医学会雑誌
  
  Volume: 73 Pages: 41-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance : the Toon Health Study2011
- Author(s)
  Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
- Journal Title
  
  Journal of Hypertension
  
  Volume: 29 Pages: 1948-1954
- DOI
  10.1097/hjh.0b013e32834abd06
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185, KAKENHI-PROJECT-22390134
[Journal Article] ヒトにおけるレジスチンの意義2011
- Author(s)
  大沼裕、大澤春彦
- Journal Title
  
  実験医学
  
  Volume: 29 Pages: 715-721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese : the Shimanami Health Promoting Program (J-SHIPP study) Development of type 2 diabetes mellitus and genotype risk score2011
- Author(s)
  Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Makino H, Kohara K, Miki T
- Journal Title
  
  Metabolism
  
  Volume: 60(11) Pages: 1634-1640
- DOI
  10.1016/j.metabol.2011.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185, KAKENHI-PROJECT-22659143, KAKENHI-PROJECT-23390188
[Journal Article] Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus.2010
- Author(s)
  Okamoto, K., Yasuda, K. (16番目), Osawa, H. (17), Nanjo, K. (18), Kadowaki, T. (19), Kasuga, M. (20), ほか19名
- Journal Title
  
  Am J Hum Genet 86(1)
  
  Pages: 54-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population2010
- Author(s)
  Onuma H, Tabara Y, Kawamura R, Tanaka T, Ohashi J, Nishida W, Takata Y, Ochi M, Yamada K, Kawamoto R, Kohara K, Miki T, Makino H, Osawa H
- Journal Title
  
  PLoS One
  
  Volume: 5
- DOI
  10.1371/journal.pone.0009718
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population2010
- Author(s)
  Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, Nishida W, Ohashi J, Miki T, Kohara K, Makino H, Osawa H
- Journal Title
  
  J Hum Genet
  
  Volume: 55 Pages: 600-604
- DOI
  10.1038/jhg.2010.75
- NAID
  10030736734
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?2010
- Author(s)
  Osawa H, et al.
- Journal Title
  
  Diabetologia.
  
  Volume: 53 Pages: 795-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] レジスチンの臨床的意義2010
- Author(s)
  大沼裕, 大澤春彦
- Journal Title
  
  Annual Review 糖尿病・代謝・内分泌 2010巻
  
  Pages: 138-144
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?2010
- Author(s)
  Osawa, H., Tabara, Y., Ohashi, J., Kawamura, R., Onuma, H., and Makino, H.
- Journal Title
  
  Diabetologia
  
  Volume: 53 Pages: 795-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] レジスチン2010
- Author(s)
  大沼裕, 大澤春彦
- Journal Title
  
  日本臨末増刊号2 肥満症 68巻
  
  Pages: 100-104
- NAID
  40020522158
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population?2010
- Author(s)
  Osawa H, Tabara Y, Ohashi J, Kawamura R, Onuma H, Makino H
- Journal Title
  
  Diabetologia.
  
  Volume: 53 Pages: 795-797
- DOI
  10.1007/s00125-010-1665-4
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] レジスチン2010
- Author(s)
  大沼裕, 大澤春彦
- Journal Title
  
  日本臨床
  
  Volume: 68(増刊号2) Pages: 100-104
- NAID
  40020522158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] A at single nucleotide polymorphism-358 is required for G at-420 to confer the highest plasma resistin in the general Japanese population2010
- Author(s)
  Onuma, H., Tabara, Y., Kawamura, R., Tanaka, T., Ohashi, J., Nishida, W., Takata, Y., Ochi, M., Yamada, K., Kawamoto, R., Kohara, K., Miki, T., Makino, H., and Osawa, H.
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] レジスチンの臨床的意義2010
- Author(s)
  大沼裕, 大澤春彦
- Journal Title
  
  Annual Review糖尿病・代謝・内分泌
  
  Pages: 138-144
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591141
[Journal Article] The PPARγPro12Ala Pro/Pro and resistin SNP-420G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.2009
- Author(s)
  Osawa, H., Makino, H. (11番目), ほか10名
- Journal Title
  
  Clin Endocrinol 71
  
  Pages: 341-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] The PPAR γ Pro12Ala Pro/Pro and resistin SNP-420G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.2009
- Author(s)
  Osawa H, et al
- Journal Title
  
  Clin Endocrinol 71
  
  Pages: 341-345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.2009
- Author(s)
  Tabara, Y., Osawa, H. (2番目), Makino, H. (8人中8番目), ほか5名
- Journal Title
  
  Diabetes 58(2)
  
  Pages: 493-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association.2009
- Author(s)
  Miyake, K., Yasuda, K. (4番目), Osawa, H. (6番目), Makino, H. (32番目), Nanjo, K. (33), Kadowaki, T. (34), Kasuga, M. (35人中35番目), ほか28名
- Journal Title
  
  J Hum Genet 54(4)
  
  Pages: 236-41
- NAID
  10030730081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.2009
- Author(s)
  Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Miki T, Kohara K, Makino H.
- Journal Title
  
  Diabetes. 58
  
  Pages: 493-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study2008
- Author(s)
  Tabara Y, Osawa H, Kawamoto R, Tachibana-Iimori R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 93 Pages: 715-722
- DOI
  10.1210/jc.2007-0397
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.2008
- Author(s)
  Yasuda, K., Miyake, K., Osawa, H. (5番目), Makino, H. (44番目), Nanjo, K. (45), Kadowaki, T. (46), Kasuga, M. (47人中47番目), ほか40名
- Journal Title
  
  Nature Genetics 40(9)
  
  Pages: 1092-1097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] The G/G genotype of single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2a.2008
- Author(s)
  Osawa, H., Makino, H. (15人中15番目), ほか13名
- Journal Title
  
  Clin Endocrinol 69
  
  Pages: 36-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] レジスチン-ヒトのインスリン抵抗性における意義-2008
- Author(s)
  大澤春彦、牧野英一
- Journal Title
  
  臨床化学 37
  
  Pages: 258-263
- NAID
  10025632074
- Data Source
  KAKENHI-PROJECT-19591055
[Journal Article] The G/G genotype of single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binding of AP2 α2008
- Author(s)
  Osawa, H., et. al.
- Journal Title
  
  Clin Endocrinol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] No association of INSIG2 gene rs7566605 polymorphism with being overweight in Japanese population2008
- Author(s)
  Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K
- Journal Title
  
  Obesity 16
  
  Pages: 211-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population2008
- Author(s)
  Tabara Y, Osawa H, Kawamoto R, Tachibana R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K.
- Journal Title
  
  J Clin Endocrinol Metab. 93
  
  Pages: 715-722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Serum resistin is positively associated with the accumulation of metabolic syndrome factors in type 2 diabetes2008
- Author(s)
  Osawa, H., et. al.
- Journal Title
  
  Clin Endocrinol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population2008
- Author(s)
  Tabara Y, Kawamoto R, Osawa H, Nakura J, Makino H, Miki T, Kohara K
- Journal Title
  
  Obesity
  
  Volume: 16 Pages: 211-215
- DOI
  10.1038/oby.2007.25
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] レジスチン-ヒトのインスリン抵抗性における意義-2008
- Author(s)
  大澤春彦, 他
- Journal Title
  
  臨床化学 37
  
  Pages: 258-263
- NAID
  10025632074
- Data Source
  KAKENHI-PROJECT-19591055
[Journal Article] Resistin, glomerular filtration rate, and insulin resistance.2008
- Author(s)
  Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K.
- Journal Title
  
  Hypertension 51(ell)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4, 087 Japanese subjects.2008
- Author(s)
  Miyake, K., Yasuda, K. (4番目), Osawa, H. (5番目), Makino, H. (20番目), Nanjo, K. (21), Kadowaki, T. (22), Kasuga, M. (23人中23番目), ほか16名
- Journal Title
  
  J Hum Genet 53(2)
  
  Pages: 174-180
- NAID
  10021248002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Resistin, glomerular filtration rate, and insulin resistance2008
- Author(s)
  Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K
- Journal Title
  
  Hypertension
  
  Volume: 51
- DOI
  10.1161/hypertensionaha.107.102046
- Data Source
  KAKENHI-PROJECT-20390185
[Journal Article] Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.2007
- Author(s)
  Osawa H. et al.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 342-346
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] Frequency of the G/G genotype of resistin single nucleotide polymorphism at -420 appears to be increased in younger-onset type 2 diabetes.2007
- Author(s)
  Ochi, M., Osawa, H., Kadowaki, T. (13番目), Kasuga, M. (15番目), Makino, H. (16人中16番目), ほか11名
- Journal Title
  
  Diabetes 56
  
  Pages: 2834-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.2007
- Author(s)
  Osawa H., et al.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 342-346
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.2007
- Author(s)
  Osawa H..et al.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 342-346
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL, and high sensitivity CRP in the Japanese general population2007
- Author(s)
  Osawa, H., Makino, H. (12人中12番目), ほか10名
- Journal Title
  
  Diabetes Care 30
  
  Pages: 1501-1506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.2007
- Author(s)
  Osawa, H.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 342-346
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL, and high sensitivity CRP in the Japanese general population2007
- Author(s)
  Osawa, H., et. al.
- Journal Title
  
  Diabetes Care 30
  
  Pages: 1501-1506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] A newly identified 50 kDa protein which is associated with phosphodiesterase 3B is phosphorylated by insulin in rat adipocytes.2005
- Author(s)
  Onuma, H., Osawa, H., Makino, H., et al.
- Journal Title
  
  Biochem Biophys Res Commun 337
  
  Pages: 976-982
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590939
[Journal Article] A case of fulminant type 1 diabetes associated with high titer of Coxsackie B3 virus antibody2005
- Author(s)
  Nishida W, Hasebe S, Kawamura R, Hashiramoto M, Onuma H, Osawa H, Makino H
- Journal Title
  
  Journal of the Japan Diabetes Society (in press)
- NAID
  10016604665
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590946
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.2005
- Author(s)
  Osawa H. et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 596-602
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.2005
- Author(s)
  Osawa H..et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 596-602
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] A newly identified 50 kDa protein which is associated with phosphodiesterase 3B is phosphorylated by insulin in rat adipocytes.2005
- Author(s)
  Onuma, H., Osawa, H, Makino, H.et al.
- Journal Title
  
  Biochem Biophys Res Commun 337
  
  Pages: 976-982
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590939
[Journal Article] A newly identified 50kDa protein which is associated with phosphodiesterase 3B is phosphorylated by insulin in rat adipocytes.2005
- Author(s)
  Onuma, H., Osawa, H., Makino, H.et al.
- Journal Title
  
  Biochem Biophys Res Commun 337
  
  Pages: 976-982
- Data Source
  KAKENHI-PROJECT-17590939
[Journal Article] 発症時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005
- Author(s)
  西田亙, 長谷部晋士, 川村良一, 柱本満, 大沼裕, 大澤春彦, 牧野英一
- Journal Title
  
  糖尿病 (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590946
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.2005
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 596-602
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes2005
- Author(s)
  Osawa H, et al.
- Journal Title
  
  Biochem Biophys Res Common 335
  
  Pages: 596-602
- Data Source
  KAKENHI-PROJECT-17590938
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.2005
- Author(s)
  Osawa, H et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 596-602
- Data Source
  KAKENHI-PROJECT-17019047
[Journal Article] 発病時コクサッキーB3ウィルス中和抗体価の上昇がみられた劇症1型糖尿病の1例2005
- Author(s)
  西田亙, 長谷部晋士, 川村良一, 柱本満, 大沼裕, 大澤春彦, 牧野英一
- Journal Title
  
  糖尿病 (In press)
- Data Source
  KAKENHI-PROJECT-15590946
[Journal Article] Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.2005
- Author(s)
  Osawa H., et al.
- Journal Title
  
  Biochem Biophys Res Commun 335
  
  Pages: 596-602
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] The G/G Genotype of a resistin single-nucleotide polymorphism at-420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/32004
- Author(s)
  Osawa H et al.
- Journal Title
  
  Am J Hum Genet 75
  
  Pages: 678-686
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] The G/G Genotype of a resistin single-nucleotide polymorphism at -420increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.2004
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Am J Hum Genet 75
  
  Pages: 678-686
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] The G/G Genotype of a resistin single-nucleotide polymorphism at-420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.2004
- Author(s)
  Osawa H et al.
- Journal Title
  
  Am J Hum Genet 75
  
  Pages: 678-686
- Data Source
  KAKENHI-PROJECT-16046218
[Journal Article] The G/G Genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.2004
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Am J Hum Genet 75
  
  Pages: 678-686
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleon a polymorphisms in the FOXC2 gene : The absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes.2003
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Diabetes 52
  
  Pages: 562-567
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the FOXC2 gene : The absence of evidence for the association of three frequent single nucleotide polymorphisms and four common haplotypes with Japanese type 2 diabetes.2003
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Diabetes 52
  
  Pages: 562-567
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the 5' flanking region of the human phosphodiesterase 3B gene : Absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.2003
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Mol Genet Metab 79
  
  Pages: 43-51
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the 5 flanking region of the human phosphodiesterase 3B gene : Absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes.2003
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Mol Genet Metab 79
  
  Pages: 43-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the resistin gene : The absence of evidence for the association of three identified single nucleotide polymorphisms with Japanese type 2 diabetes.2002
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Diabetes 51
  
  Pages: 863-866
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Identification of novel C253Y missense and Y864X nonsense mutations in the insulin receptor gene in type A insulin resistant patients.2001
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Clin Genet 59
  
  Pages: 194-197
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the insulin gene : Evidence for a high frequency of g.-23T>A in Japanese subjects.2001
- Author(s)
  Osawa, H.
- Journal Title
  
  Biochem Biophys Res Commun 286
  
  Pages: 451-455
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] Systematic search for single nucleotide polymorphisms in the insulin gene : Evidence for a high frequency of g.-23T>A in Japanese subjects.2001
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Biochem Biophys Res Commun 286
  
  Pages: 451-455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] A systematic search for single nucleotide polymorphisms (SNPs) in the insulin receptor gene : Association of an sSNP with hyperlipidemia in Japanese type 2 diabetic subjects.2001
- Author(s)
  Osawa, H., et al.
- Journal Title
  
  Clin Genet 60
  
  Pages: 479-481
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12204007
[Journal Article] The PPARy Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population
- Author(s)
  Osawa H, et.al.
- Journal Title
  
  Clinical Endocrinology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17019047
[Presentation] レジスチンSNP-420/SNP-358ハプロタイプと白血球数は相互に血中レジスチン高値と関連する2020
- Author(s)
  川村良一、田原康玄、高田康徳、丸山広達、高門美沙季、池田陽介、羽立登志美、斉藤功、大澤春彦
- Organizer
  日本糖尿病学会中国四国地方会第58回総会
- Data Source
  KAKENHI-PROJECT-19K07868
[Presentation] レジスチンSNP-420/-358ハプロタイプと喫煙は相互に血中レジスチンを高める2020
- Author(s)
  羽立登志美、川村良一、高田康徳、田原康玄、丸山広達、高門美沙季、池田陽介、斉藤　功、大澤春彦
- Organizer
  日本糖尿病学会中国四国地方会第58回総会
- Data Source
  KAKENHI-PROJECT-20K08910
[Presentation] 血中レジスチンの5年間の変化はSNP-420と環境因子スコアの相互作用により規定される【東温ゲノムスタディ】2020
- Author(s)
  川村良一、田原康玄、高田康徳、丸山広達、高門美沙季、池田陽介、羽立登志美、西田亙、大沼裕、谷川武、斉藤功、大澤春彦
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K07868
[Presentation] SNP-420のメチル化率は、C/C型において血中レジスチン及びインスリン抵抗性と負に関連する「東温ゲノムスタディ」2018
- Author(s)
  羽立登志美, 川村良一, 田原康玄, 高田康徳, 高門美沙季, 丸山広達, 西田亙, 松下由実, 大沼裕, 谷川武, 斉藤功, 大澤春彦
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K09754
[Presentation] ヒトにおける血中レジスチン調節機構と体質2017
- Author(s)
  大澤春彦
- Organizer
  第67回日本体質医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09754
[Presentation] 糖尿病感受性遺伝子レジスチンSNP-420のメチル化は血中レジスチンと関連する2015
- Author(s)
  大沼　裕、田原康玄、川本龍一、門田優子、川村良一、高田康徳、西田　亙、小原克彦、牧野英一、三木哲郎、大澤　春彦
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461359
[Presentation] The DNA methylation at single nucleotide polymorphism (SNP)-420 in the human resistin gene is inversely associated with plasma resistin in the general Japanese population2015
- Author(s)
  Hiroshi Onuma, Yasuharu Tabara, Ryoichi Kawamura, Ryuichi Kawamoto, Wataru Nishida, Yasunori Takata, Hideichi Makino, Katsuhiko Kohara, Tetsuro Miki, and Haruhiko Osawa
- Organizer
  American Diabetes Association 75th scientific sessions
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461359
[Presentation] 一般歯科医院における血糖モニタリングの有用性【愛媛Dental Diabetes スタディ】2012
- Author(s)
  原瀬忠広,西田亙,重松健司,小林悟,佐古弘文,伊藤史郎,村上始,西田圭,井上洋,藤澤雅人,吉津宏,川村良一,高田康徳,大沼裕,清水恵太,浜川裕之,大澤春彦
- Organizer
  第55回日本糖尿病学会年次学術
- Place of Presentation
  神奈川県パシフィコ横浜
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22590530
[Presentation] 血中レジスチンは OGTT 正常型かつ 21≦BMI<23 の一般住民において各種インスリン指標と関連する【東温スタディ】2012
- Author(s)
  西田亙,川村良一,高田康徳,相引真代,芝真希,能美幸信,門田優子,岡本愛,西宮達也,田原康玄,三木哲郎,斉藤功,谷川武,大沼裕,大澤春彦
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  神奈川県パシフィコ横浜
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22590530
[Presentation] 2型糖尿病患者入院前後における単球レジスチン遺伝子発現とシトシンメチル化の解析2012
- Author(s)
  大沼裕、川村良一、門田優子、松下由美、相引真代、芝真希、能美幸信、高田康徳、西田亙、牧野英一、大澤春彦
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590985
[Presentation] ヘマトクリットとインスリン抵抗性，インスリン感受性ならびに無症候性脳血管障害との関連2012
- Author(s)
  田原康玄・大澤春彦・伊賀瀬道也・斉藤　功・西田　亙・小原克彦・櫻井　進川本龍一・上谷英里・櫃本真一・大沼　裕・多喜田理絵・高田康徳・永井勅久岡田陽子・城戸知子・越智南美子・谷川武・三木哲郎
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] 血中レジスチンはレジスチン遺伝子のSNP-420、SNP-358により強く規定される一方、2型糖尿病感受性遺伝子のトランス作用によっても影響される2011
- Author(s)
  大沼裕, 田原康玄, 西田亙, 高田康徳, 大澤春彦, 他
- Organizer
  第61回日本体質医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591141
[Presentation] 血中レジスチンはプロモーターSNPによるシス作用、および他遺伝子のトランス作用に規定される2011
- Author(s)
  大沼裕、田原康玄、川村良一、田中高志、大橋順、西田亙、高田康徳、越智正昭、山田一哉、川本龍一、小原克彦、三木哲郎、牧野英一、大澤春彦
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22590985
[Presentation] 地域一般住民において血中レジスチンはOGTT 正常型かつ非肥満群のインスリン抵抗性/感受性指数と関連する東温スタディ2011
- Author(s)
  西田亙,川村良一,高田康徳,門田優子,星衛かよ子,大森悠史,荒川愛,谷口裕美,西宮達也,松下由美,相引真代,田原康玄,三木哲郎,斉藤功,櫻井進,谷川武,大沼裕,大澤春彦
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  北海道札幌市
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590530
[Presentation] 一般地域住民においてレジスチンは一塩基多型(SNP)-420及びSNP-358は代謝関連の量的形質とは関連しない2011
- Author(s)
  大澤春彦, 他
- Organizer
  弟53回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] Relatively lower central aortic pressure in subjects with impaired insulin sensitivity and resistance: The Toon Health Study2011
- Author(s)
  Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
- Organizer
  Council for High Blood Pressure Research
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] 生活習慣病における遺伝因子-2型糖尿病を中心に-2010
- Author(s)
  大澤春彦
- Organizer
  第60回日本体質医学会総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21591141
[Presentation] インスリン投与を契機に 2型から 1 型糖尿病に転換した 6 症例のインスリン遺伝子と膵島関連ペプチドに対する T 細胞反応性の解析2010
- Author(s)
  西田亙,森山啓明,永田正男,中村舞,今川彰久,花房俊昭,高橋健二,末廣正,山田祐也,中條大輔,川村良一,高田康徳,大沼裕,大澤春彦,牧野英一
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  ホテルグランビア岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22590530
[Presentation] 血中レジスチンは全ゲノム関連解析(GWAS)で同定された2型糖尿病感受性一塩基多型(SNP)THADAと関連する2010
- Author(s)
  大澤春彦, 他
- Organizer
  弟53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] Relevance of resistin in human insulin resistance2009
- Author(s)
  Hiroshi Onuma, Haruhiko Osawa et al
- Organizer
  The 2^<nd> Insulin resistance in metabolic disease forum
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-21591141
[Presentation] 一般住民において、PPAR γ Pro12Ala Pro/Pro型とレジスチンSNP-426G/G型は血中レジスチンと相乗的に関連する2009
- Author(s)
  大澤春彦, 他
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-17019047
[Presentation] 2型糖尿病においで血中レジスチンはメタボリックシンドローム因子数と正に関連する2008
- Author(s)
  大澤春彦他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-17019047
[Presentation] 2型糖尿病において血中レジスチンはメタボリックシンドローム因子数と正に関連する2008
- Author(s)
  大澤春彦, 他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591055
[Presentation] Reduced high-molecular weight adiponectin and elevated hsCRP are synergistic risk factors for metabolic syndrome in a large scale middle-aged to elderly population : The J-SHIPP study2008
- Author(s)
  Tabara Y, Osawa H, Kawamoto R, Tachibana R, Yamamoto M, Nakura J, Miki T, Makino H, Kohara K
- Organizer
  22nd Scientific Meeting, the International Society of Hypertension
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] メタボリックシンドロームに対する高分子量アディポネクチンと高感度CRPとの相乗的相関2008
- Author(s)
  田原康玄, 大澤春彦, 川本龍一, 名倉潤, 三木哲郎, 牧野英一, 小原克彦
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] Resistin, GFR and insulin resistance2008
- Author(s)
  Tabara Y, Igase M, Osawa H, Makino H, Miki T, Kohara K
- Organizer
  22nd Scientific Meeting, the International Society of Hypertension
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20390185
[Presentation] 2 型糖尿病において血中レジスチンはメタボリックシンドローム因子数と正に関連する2008
- Author(s)
  大澤春彦、西田亙、高田康徳、牧野英一, 他
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591055
[Presentation] ヒトのインスリン抵抗性におけるレジスチンの意義2008
- Author(s)
  大澤春彦、牧野英一, 他
- Organizer
  第42回糖尿病学の進歩
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-19591055
[Presentation] ヒトのインスリン抵抗性におけるレジスチンの意義2008
- Author(s)
  大沼裕、大澤春彦、牧野英一、他
- Organizer
  第53回日本臨床医学会中国・四国支部総会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-19599016
[Presentation] ヒトのインスリン抵抗性におけるレジスチシの意義2008
- Author(s)
  大澤春彦, 他
- Organizer
  第42回糖尿病学の進歩
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-19591055
[Presentation] Serum resistin is associated with multiple factors related to metabolic syndronie in type 2 diabetes.2007
- Author(s)
  Osawa, H., et. al.
- Organizer
  American Diabetes Association 67th Scientific Sessions
- Place of Presentation
  Chicago, IL, USA
- Data Source
  KAKENHI-PROJECT-17019047
[Presentation] 一般住民において、血中レジスチンは、SNP-420により主に規定され、インスリン抵抗性、低HDL、高感度CRPと関連する2007
- Author(s)
  大澤春彦, 他
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17019047
[Presentation] 血中レジスチンと糖尿病感受性遺伝子レジスチンSNP-420のメチル化との関連
- Author(s)
  大沼裕、田原康玄、門田優子、川本龍一、小原克彦、三木哲郎、川村良一高田康徳、西田亙、牧野英一、大澤春彦
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461359

1. ONUMA Hiroshi (00294794)

# of Collaborated Projects: 21 results

# of Collaborated Products: 30 results
2. MAKINO Eiichi (50009578)

# of Collaborated Projects: 14 results

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62. 山下政克

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OSAWA Haruhiko 大澤 春彦

OOSAWA Haruhiko 大澤 春彦

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レジスチン遺伝子発現制御機構におけるプロモーターSNP配列特異的効果の統合的解明Principal Investigator

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Regulation of human resistin gene expression by SNPs determining epigenetics and environmental factorsPrincipal Investigator

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Regulation of the human resistin gene expression by SNPs, epigenetics, and environmental factorsPrincipal Investigator

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OSAWA Haruhiko 大澤春彦

OOSAWA Haruhiko 大澤春彦