Chihara Kazuyasu 千原一泰

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CHIHARA Kazuyasu 千原一泰

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Researcher Number	00314948
Other IDs
Affiliation (Current)	2025: 福井大学, 学術研究院医学系部門, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2023: 福井大学, 学術研究院医学系部門, 准教授 2011 – 2015: 福井大学, 医学部, 准教授 2010: University of Fukui, 医学部, 講師 2009: University of Fukui, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related / Neurochemistry/Neuropharmacology Except Principal Investigator Pathological medical chemistry / Basic Section 49070:Immunology-related / Basic Section 49010:Pathological biochemistry-related
Keywords	Principal Investigator 免疫応答 / Syk / NF-κB / チロシンリン酸化 / ユビキチン化 / NF-kappa B / MALT1 / CARD9 / C型レクチン受容体 / 3BP2 … More / カイニン酸 / 神経細胞死 / 小胞体ストレス / 小胞体ストレス応答 / グリア細胞 … More Except Principal Investigator チロシンキナーゼ / C型肝炎ウイルス / 3BP2 / ゲノム編集 / 感染宿主因子 / 抗ウイルス応答 / 自然免疫 / ストレス応答 / ウイルス感染 / 二重鎖RNA / Abl / HCV / ウイルス / アダプタータンパク質 / ウイルス-宿主相互作用 / インターフェロン / プロテオーム解析 / 糖尿病 / シグナル伝達 / 分子病態学 Less

Regulation of anti-fungal immunity by adaptor protein 3BP2Principal Investigator
- Principal Investigator
  
  千原一泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  University of Fukui
Regulatory mechanism of virus particle production by protein-tyrosine kinase Abl.
- Principal Investigator
  
  Sada Kiyonao
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  University of Fukui
Processing of double-stranded RNA during recovery of the cell from the double-stranded RNA stress
- Principal Investigator
  
  Takeuchi Kenji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  University of Fukui
Novel function of tyrosine kinase Abl as a host factor against virus infection
- Principal Investigator
  
  Kiyonao Sada
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Tyrosine phosphorylation of a viral protein in the hepatitis C virus life cycle
- Principal Investigator
  
  Yamauchi Shota
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Role of the regulation of B cell protein-tyrosine kinase by hepatitis C virus
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cells
- Principal Investigator
  
  SADA Kiyonao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Fukui
Functional analysis of ER stress sensor OASIS on the neuronal protection from the toxicity of kainic acid.Principal Investigator
- Principal Investigator
  
  CHIHARA Kazuyasu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  University of Fukui

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation Book

[Book] C型レクチンによるマスト細胞の活性化メカニズム、臨床免疫・アレルギー科2018
- Author(s)
  千原一泰，本定千知，木村幸弘，竹内健司，藤枝重治，石塚　全，定　清直
- Total Pages
  5
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-17K08656
[Book] 関節リウマチ治療におけるSyk阻害薬の可能性を探る 3(4)2010
- Author(s)
  千原一泰、定清直
- Publisher
  分子リウマチ治療(先端医学社)
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] Novel roles of tyrosine kinase Abl as a host factor for microbial infection.2023
- Author(s)
  定清直、竹内健司、千原一泰
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 1 Pages: 96-99
- DOI
  10.14952/SEIKAGAKU.2023.950096
- ISSN
  0037-1017
- Year and Date
  2023-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation2022
- Author(s)
  Chihara Kazuyasu、Chihara Yuri、Takeuchi Kenji、Sada Kiyonao
- Journal Title
  
  Biochemical Journal
  
  Volume: 479 Issue: 4 Pages: 503-523
- DOI
  10.1042/bcj20210707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A2022
- Author(s)
  Miyamoto Daisuke、Takeuchi Kenji、Chihara Kazuyasu、Fujieda Shigeharu、Sada Kiyonao
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 4 Pages: 101804-101804
- DOI
  10.1016/j.jbc.2022.101804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07354
[Journal Article] Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum2021
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Chihara Kazuyasu、Sada Kiyonao、Wang Mao‐Hsien、Yazawa Takashi、Taniguchi Takanobu、Ishibashi Takaharu、Masuoka Takayoshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 160 Issue: 3 Pages: 342-355
- DOI
  10.1111/jnc.15556
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-20K07354, KAKENHI-PROJECT-20K09814
[Journal Article] Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway.2021
- Author(s)
  Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H.
- Journal Title
  
  Translational Research
  
  Volume: 227 Pages: 53-63
- DOI
  10.1016/j.trsl.2020.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells2017
- Author(s)
  Chihara Kazuyasu、Kato Yuji、Yoshiki Hatsumi、Takeuchi Kenji、Fujieda Shigeharu、Sada Kiyonao
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 11480-11480
- DOI
  10.1038/s41598-017-11915-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08656
[Journal Article] Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk2017
- Author(s)
  Honjoh Chisato、Chihara Kazuyasu、Yoshiki Hatsumi、Yamauchi Shota、Takeuchi Kenji、Kato Yuji、Hida Yukio、Ishizuka Tamotsu、Sada Kiyonao
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 46064-46064
- DOI
  10.1038/srep46064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-15K09213
[Journal Article] STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha2016
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Honjoh, C., Kato, Y., Yoshiki, H., Hotta, H., and Sada, K.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 38336-38336
- DOI
  10.1038/srep38336
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19021
[Journal Article] Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 36 Pages: 21857-21864
- DOI
  10.1074/jbc.m115.666859
- NAID
  120005973616
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19021, KAKENHI-PROJECT-25460383
[Journal Article] Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with Vav3 in chicken DT40 cells2014
- Author(s)
  Chihara, K., Kimura, Y., Honjoh, C., Yamauchi, S., Takeuchi, K., Sada, K.
- Journal Title
  
  Exp. Cell Res.
  
  Volume: 322 Issue: 1 Pages: 99-107
- DOI
  10.1016/j.yexcr.2013.12.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591105, KAKENHI-PROJECT-25460383
[Journal Article] 関最新節リウマチ学 ―寛解・治癒を目指した研究と最新治療― Syk阻害薬2014
- Author(s)
  本定千知、千原一泰、木村幸弘、竹内健司、定　清直
- Journal Title
  
  日本臨牀増刊号「最新関節リウマチ学─寛解・治癒を目指した研究と最新治療」
  
  Volume: なし Pages: 521-524
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.2014
- Author(s)
  Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 45 Pages: 31565-75
- DOI
  10.1074/jbc.m114.581322
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-25460383, KAKENHI-PROJECT-26293368
[Journal Article] Syk inhibitors2013
- Author(s)
  千原一泰、木村幸弘、本定千知、竹内健司、定　清直
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 36 Issue: 4 Pages: 197-202
- DOI
  10.2177/jsci.36.197
- NAID
  10031196416
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] 関節リウマチ　ケアからキュアを目指した治療：Syk 阻害薬2013
- Author(s)
  木村幸弘、千原一泰、竹内健司、定　清直
- Journal Title
  
  日本臨牀
  
  Volume: 71(7) Pages: 1248-1252
- Data Source
  KAKENHI-PROJECT-25460383
[Journal Article] Spleen tyrosine kinase (Syk)の生理的役割とその阻害薬の作用.2012
- Author(s)
  千原一泰
- Journal Title
  
  リウマチ科
  
  Volume: 47(6) Pages: 694-699
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Spleen tyrosine kinase (Syk)の生理的役割とその阻害薬の作用2012
- Author(s)
  千原一泰, 中島謙治, 竹内健司, 定清直
- Journal Title
  
  リウマチ科
  
  Volume: 47(6) Pages: 694-699
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] 次世代低分子化合物:Syk 阻害薬. 特集関節リウマチの最新情報-寛解を目指した診断と治療の新展開-2012
- Author(s)
  中島謙治, 千原一泰, 竹内健司, 定清直
- Journal Title
  
  最新医学
  
  Volume: 67(2) Pages: 101-106
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
- Journal Title
  
  PLoS ONE
  
  Volume: 7(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells2011
- Author(s)
  Chihara, K., Nakashima, K., Takeuchi, K., and Sada, K
- Journal Title
  
  Genes Cells
  
  Volume: 16(12) Pages: 1133-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism2011
- Author(s)
  Ogi, K., Nakashima, K., Chihara, K., Takeuchi, K., Horiguchi, T., Fujieda, S., and Sada, K
- Journal Title
  
  Genes Cells
  
  Volume: 16(9) Pages: 951-960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation.2011
- Author(s)
  Horiguchi T, Ishiguro N, Chihara K, Ogi K, Nakashima K, Sada K, Hori-Tamura N
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation2011
- Author(s)
  Horiguchi, T., Ishiguro, N., Chihara, K., Ogi, K., Nakashima, K., Sada, K., and Hori-Tamura, N
- Journal Title
  
  J. Agric. Food. Chem
  
  Volume: 59(10) Pages: 5595-5601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
- Journal Title
  
  Microbiol. Immunol
  
  Volume: 55(11) Pages: 774-782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis.2010
- Author(s)
  Hino, S.Kondo, S.Yoshinaga, K.Saito, A.Murakami, T.Kanemoto, S.Sekiya, H.Chihara, K.Aikawa, Y.Hara, H.Kudo, T.Sekimoto, T.Funamoto, T.Chosa, E.Imaizumi, K.
- Journal Title
  
  J.Bone Miner.Metab. 28(2)
  
  Pages: 131-138
- NAID
  10027207004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る2010
- Author(s)
  千原一泰、定清直
- Journal Title
  
  分子リウマチ治療
  
  Volume: 3 Pages: 14-17
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る. 特集次世代の低分子量化合物は生物学的製剤を超えることができるか2010
- Author(s)
  千原一泰, 定清直
- Journal Title
  
  分子リウマチ治療
  
  Volume: 3(4) Pages: 186-189
- NAID
  40017367198
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Regulation of ER molecular chaperone prevents bone loss in a murinemodel for osteoporosis.2010
- Author(s)
  Hino S-I, Kondo S, Yoshinaga K, Saito A, Murakami T, Kanemoto S, Sekiya H, Chihara K, Aikawa Y, Hara H, Kudo T, Sekimoto T, Funamoto T, Chosa E, Imaizumi K
- Journal Title
  
  Journal of Bone and Mineral Metabolism 28(2)
  
  Pages: 131-138
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る2010
- Author(s)
  千原一泰
- Journal Title
  
  分子リウマチ治療
  
  Volume: 3(4) Pages: 186-189
- Data Source
  KAKENHI-PROJECT-22590285
[Journal Article] Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainicacid in OASIS-deficient mice.2009
- Author(s)
  Chihara, K.Saito, A.Murakami, T.Hino, S.Aoki, Y.Sekiya, H.Aikawa, Y.Wanaka, A., Imaizumi, K.
- Journal Title
  
  J.Neurochem 110(3)
  
  Pages: 956-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.2009
- Author(s)
  Murakami, T.Saito, A.Hino, S.Kondo,S.Kanemoto, S.Chihara, K.Sekiya, H.Tsumagari, K.Ochiai, K.Yoshinaga, K.Saitoh, M.Nishimura, R.Yoneda, T.Kou, I.Furuichi, T.Ikegawa, S.Ikawa, M.Okabe, M.Wanaka, A., Imaizumi, K.
- Journal Title
  
  Nat.Cell Biol. 11(10)
  
  Pages: 1205-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.2009
- Author(s)
  Murakami T, Saito A, Hino S-I, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K.
- Journal Title
  
  Nature Cell Biology 11(10)
  
  Pages: 1205-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Journal Article] Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid in OASIS-deficient mice.2009
- Author(s)
  Chihara K, Saito A, Murakami T, Hino S-I, Aoki Y, Sekiya H, Aikawa Y, Wanaka A, Imaizumi K.
- Journal Title
  
  Journal of Neurochemistry 110(3)
  
  Pages: 956-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプター蛋白質3BP2によるCARD9の機能調節機構の解析2023
- Author(s)
  坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
- Organizer
  日本生化学会北陸支部第４１回大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] アダプター蛋白質3BP2によるCARD9シグナル伝達機構の調節2023
- Author(s)
  坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
- Organizer
  第９６回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022
- Author(s)
  千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定　清直
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022
- Author(s)
  宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定　清直
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06897
[Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022
- Author(s)
  宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定　清直
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022
- Author(s)
  千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定　清直
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] アダプター蛋白質3BP2はC型レクチンDectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2021
- Author(s)
  千原一泰，千原悠里，竹内健司，定　清直
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07354
[Presentation] 非受容体型チロシンキナーゼAblとC型肝炎ウイルスの相互作用2019
- Author(s)
  宮本大輔，竹内健司，千原一泰，定　清直
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] ゲノム編集マウスを利用したB細胞におけるアダプタータンパク質3BP2の機能解析2018
- Author(s)
  千原一泰, 竹内健司, 千原悠里, 宮本大輔, 定　清直
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] アダプター蛋白質3BP2による貪食細胞の機能調節メカニズム2017
- Author(s)
  千原一泰, 加藤雄士, 竹内健司, 藤枝重治, 定　清直
- Organizer
  日本生化学会北陸支部第35回大会
- Data Source
  KAKENHI-PROJECT-17K08656
[Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015
- Author(s)
  本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Role of c-Abl in hepatitis C virus particle assembly2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-15K19021
[Presentation] C型肝炎ウイルス粒子形成におけるc-Ablの役割2015
- Author(s)
  山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015
- Author(s)
  本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
- Organizer
  日本生化学会北陸支部第33回大会
- Place of Presentation
  富山
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] チロシンキナーゼによるHCV複製の制御機構2015
- Author(s)
  山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
- Organizer
  日本生化学会北陸支部第33回大会, シンポジウム「病原性ウイルス・免疫応答研究の最前線」
- Place of Presentation
  富山
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] Role of NS5A tyrosine phosphorylation in hepatitis C virus particle assembly2015
- Author(s)
  Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PROJECT-15K19021
[Presentation] アダプター蛋白質3BP2は分化したAML細胞においてSrc型チロシンキナーゼの活性化を促進する2015
- Author(s)
  千原一泰，吉木はつみ，加藤雄士，本定千知，山内翔太，竹内健司，定清直
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] マスト細胞におけるDectin-1の機能解析：真菌感染防御におけるマスト細胞の新たな役割．2014
- Author(s)
  千原一泰，木村幸弘，本定千知，吉木はつみ，山内翔太，竹内健司，定　清直．
- Organizer
  日本生化学会北陸支部第32回大会
- Place of Presentation
  富山大学杉谷キャンパス
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] C型レクチンDectin-1を介するマスト細胞の活性化機構2013
- Author(s)
  木村幸弘, 千原一泰, 竹内　健司, 本定千知, 藤枝重治, 定　清直
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] C型肝炎ウイルス非構造蛋白質NS5AにおけるFyn-SH2ドメインとの結合に重要なチロシン残基同定の試み2013
- Author(s)
  竹内健司, 孫　雪東, 千原一泰, Lin Deng, 勝二郁夫, 堀田　博, 定　清直
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] ニワトリDT40細胞におけるアダプター蛋白質3BP2のチロシンリン酸化とVav3との会合メカニズム2013
- Author(s)
  千原一泰, 木村幸弘, 本定千知, 竹内　健司, 定　清直
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25460383
[Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
- Organizer
  IUBMB&FEBS
- Place of Presentation
  Sevilla, Spain
- Year and Date
  2012-09-06
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルスNS5A蛋白質のSrc homology 2/3ドメイン結合能とB細胞での発現によるSrcファミリーキナーゼFynの活性化2012
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀口朋子, 孫雪東, Lin Deng, 勝二郁夫, 堀田博, 定清直
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-11
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C型肝炎ウイルスNS5AはB細胞のチロシンキナーゼFynを活性化する2012
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀口朋子, 孫雪東, Lin Deng, 勝二郁夫, 堀田博, 定清直
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells2011
- Author(s)
  千原一泰
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011
- Author(s)
  Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
- Organizer
  IUMS 2011
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] C 型肝炎ウイルス複製におけるエネルギーセンサーAMPKの役割2011
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  日本生化学会北陸支部第29回大会
- Place of Presentation
  金沢
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT2011
- Author(s)
  Sada, K., Nakashima, K., Ogi, K., and Chihara, K
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF- in RBL-2H3 cells2011
- Author(s)
  千原一泰, 中島謙治, 竹内健司, 定清直
- Organizer
  第34回日本分子生物学会年会(MBSJ2011)
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治、竹内健司、千原一泰、堀田博、定清直
- Organizer
  第83回日本生化学会大会第33回日本分子生物学会年会合同年会
- Place of Presentation
  兵庫県
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達の増強2010
- Author(s)
  扇和弘, 羽溪朋子, 中島謙治, Upasana Shukla, 千原一泰, 藤枝重治, 定清直
- Organizer
  日本生化学会北陸支部第28回大会
- Place of Presentation
  福井
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治、竹内健司、千原一泰、堀田博、定清直
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島県
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプター蛋白質の点突然変異によるB細胞シグナル伝達の増強2010
- Author(s)
  扇和弘、羽溪朋子、Upasana Shukla、千原一泰、藤枝重治、定清直
- Organizer
  日本生化学会北陸支部第28回大会
- Place of Presentation
  福井県
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達への影響2010
- Author(s)
  扇和弘, 中島謙治, シュクラウパサナ, 千原一泰, 藤枝重治, 定清直
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22590285
[Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010
- Author(s)
  中島謙治, 竹内健司, 千原一泰, 堀田博, 定清直
- Organizer
  第83回日本生化学会大会第33回日本分子生物学会年会合同学会
- Place of Presentation
  兵庫県
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプター蛋白質3BP2の点突然変異によるB細胞シグナル伝達への影響2010
- Author(s)
  扇和弘、中島謙治、シュクラウパサナ、千原一泰、藤枝重治、定清直
- Organizer
  第83回日本生化学会大会第33回日本分子生物学会年会合同年会
- Place of Presentation
  兵庫県
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達の増強2010
- Author(s)
  扇和弘, 羽溪朋子, Upasana Shukla, 千原一泰, 藤枝重治, 定清直
- Organizer
  日本生化学会北陸支部第28回大会
- Place of Presentation
  福井県
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] アダプター蛋白質3BP2の点突然変異によるB細胞シグナル伝達への影響2010
- Author(s)
  扇和弘, 中島謙治, シュクラウパサナ, 千原一泰, 藤枝重治, 定清直
- Organizer
  第83回日本生化学会大会第33回日本分子生物学会年会合同学会
- Place of Presentation
  兵庫県
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] Increased vulnerability of pyramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice.2009
- Author(s)
  Saito A, Chihara K, Murakami T, Wanaka A,, Imaizumi K.
- Organizer
  Society of Neuroscience
- Place of Presentation
  Chicago, USA.
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] 小胞体ストレスセンサーOASISの欠損がカイニン酸による神経細胞死へ与える影響2009
- Author(s)
  千原一泰、齋藤敦、村上智彦、青木悠里、和中明生、今泉和則
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  愛知県
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-21700410
[Presentation] Increased v ulnerability of py ramidal neurons to the toxicity of kainic acid in the hippocampi of OASIS-deficient mice.2009
- Author(s)
  Saito, A.Chihara, K.Murakami, T.Wanaka, A., Imaizumi, K.
- Organizer
  Society of Neuroscience 2009
- Place of Presentation
  シカゴ
- Year and Date
  2009-10-19
- Data Source
  KAKENHI-PROJECT-21700410

1. SADA Kiyonao (10273765)

# of Collaborated Projects: 7 results

# of Collaborated Products: 50 results
2. TAKEUCHI Kenji (40236419)

# of Collaborated Projects: 7 results

# of Collaborated Products: 45 results
3. HOTTA Hak (40116249)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. YAMAUCHI Shota (00728941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. UWADA Junsuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 矢澤隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 谷口隆信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 益岡尚由

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤枝重治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chihara Kazuyasu 千原 一泰

CHIHARA Kazuyasu 千原 一泰

Research Projects

Research Products

Co-Researchers

Regulation of anti-fungal immunity by adaptor protein 3BP2Principal Investigator

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Regulatory mechanism of virus particle production by protein-tyrosine kinase Abl.

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Processing of double-stranded RNA during recovery of the cell from the double-stranded RNA stress

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Novel function of tyrosine kinase Abl as a host factor against virus infection

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Tyrosine phosphorylation of a viral protein in the hepatitis C virus life cycle

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Role of the regulation of B cell protein-tyrosine kinase by hepatitis C virus

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Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cells

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Functional analysis of ER stress sensor OASIS on the neuronal protection from the toxicity of kainic acid.Principal Investigator

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[Book] C型レクチンによるマスト細胞の活性化メカニズム、臨床免疫・アレルギー科2018

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[Book] 関節リウマチ治療におけるSyk阻害薬の可能性を探る 3(4)2010

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[Journal Article] Novel roles of tyrosine kinase Abl as a host factor for microbial infection.2023

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[Journal Article] Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation2022

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[Journal Article] Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A2022

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Chihara Kazuyasu 千原一泰

CHIHARA Kazuyasu 千原一泰

[Journal Article] 関節リウマチ　ケアからキュアを目指した治療：Syk 阻害薬2013

[Journal Article] 次世代低分子化合物:Syk 阻害薬. 特集関節リウマチの最新情報-寛解を目指した診断と治療の新展開-2012