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Kamada Haruhiko  鎌田 春彦

… Alternative Names

KAMADA Haruhiko  鎌田 春彦

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Researcher Number 00324509
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2478-3818
Affiliation (Current) 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, プロジェクトリーダー
Affiliation (based on the past Project Information) *help 2018 – 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, プロジェクトリーダー
2017: 国立研究開発法人 医薬基盤・健康・栄養研究所, 創薬デザイン研究センター, プロジェクトリーダー
2016: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 創薬デザイン研究センター, プロジェクトリーダー
2015: 国立研究開発法人医薬基盤・健康・栄養研究所, バイオ創薬プロジェクト, サブプロジェクトリーダー
2015: (独)医薬基盤・健康・栄養研究所, バイオ創薬プロジェクト・サブプロジェクト, リーダー … More
2013 – 2014: 独立行政法人医薬基盤研究所, 創薬基盤研究部, 研究員
2012 – 2014: 独立行政法人医薬基盤研究所, 創薬基盤研究部, サブプロジェクトリーダー
2012: (独)医薬基盤研究所, バイオ創薬プロジェクト, サブプロジェクトリーダー
2011: 独立行政法人医薬基盤研究所, サブプロジェクトリーダー
2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, サブ・プロジェクトリーダー
2010: 独立行政法人 医薬基盤研究所, 創薬基盤研究部, サブリーダー
2010: National Institute of Biomedical Innovation, 創薬基盤研究部, サブプロジェクトリーダー
2009: National Institute of Biomedical Innovation, 基盤的研究部, 主任研究員
2009: 独立行政法人医薬基盤研究所, 基盤的研究部・創薬プロテオミクスプロジェクト, 主任研究員
2007: 医薬基盤研究所, 基盤的研究部, 主任研究員
2005 – 2006: 独立行政法人医薬基盤研究所, 基盤的研究部, 主任研究員
2004: 国立医薬品食品衛生研究所, 基礎研究第二プロジェクトチーム, 主任研究官
2004: 国立医薬食品衛生研究所, 基盤研究第二プロジェクト, 主任研究官
2004: 国立薬品食品衛生研究所, 主任研究官
2000 – 2003: 三重大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Medical pharmacy / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Medium-sized Section 50:Oncology and related fields / Medical systems / Clinical oncology / Living organism molecular science / Drug development chemistry / Hematology / Laboratory medicine … More
Except Principal Investigator
… More Biological Sciences / Basic Section 38050:Food sciences-related / Medical pharmacy / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 49010:Pathological biochemistry-related / Basic Section 34020:Analytical chemistry-related / Orthopaedic surgery / Physical pharmacy / Urology / Pathological medical chemistry / Structural biochemistry / Laboratory medicine / Biological pharmacy Less
Keywords
Principal Investigator
抗体 / 二重特異性抗体 / プロテオミクス / バイオマーカー / 乳がん / ファージ表面提示法 / 組織因子 / バイオ医薬品 / 抗体医薬 / リンカー … More / 物性 / 抗体分子 / アフィニティ精製カラム / エクソソーム / 分泌膜小胞 / EphA10 / CD3 / 分子標的治療 / タンパク質工学 / 構造変異タンパク質 / インターフェロン / バイオテクノロジー / 医薬分子設計 / 肝炎 / ビオチンラベル化 / 膜蛋白質 / プロテオーム解析 / メンブランパンニング / 発現差異解析 / プロテオーム / 抗体ライブラリ / 疾患関連タンパク質 / 一本鎖抗体 / 抗血栓性 / 単核球 / Rho Kinase / 低分子量Gたんぱく質 / C-反応性たんぱく質 / 炎症性たんぱく質 / NFκB / E-selectin / 機能性たんぱく質 / 血管内皮細胞 / 蛋白療法 / 腫瘍壊死因子 / CRP / 炎症性メディエーター / 抗凝固薬 / 細胞マイクロレオロジー装置 / 炎症 / 血流改善薬 / 抗血小板薬 / 細胞マイクロオロジー装置 / LPS / ADP / 血小板 / 血液流動性 … More
Except Principal Investigator
プロテインCインヒビター / プロテオミクス / DDS / がん治療 / 標的因子 / 食品成分 / 脂質代謝 / SREBP / スルフォラファン / 抗肥満 / CpG methylation / renal cell carcinoma / 血管内皮 / activated protein C / protein C inhibitor / 活性化プロテインC / 炎症 / HGFアクチベーター / 転移 / 薬学 / 生体分子 / 癌 / 蛋白質 / バイオコンジュゲーション / 機能性人工蛋白質 / サイトカイン / 薬物送達法 / 腫瘍壊死因子 / ファージ表面提示法 / 乳癌細胞 / 腎癌細胞 / セリンプロテアーゼインヒビター / トロンボモジュリン / uPA / 腎癌 / Drug targeting / 人工受容体 / 腫瘍溶解性ウイルス / 腸管 / 食品成分受容体 / スルファラファン / パルミトイル化 / 血管新生 / HB-EGF / 中和抗体 / 網膜色素上皮細胞 / 線維化 / 線維性瘢痕 / 脈絡膜血管新生 / 加齢黄斑変性 / プロテアソーム / 腸内細菌叢 / ブロッコリー / 血中循環癌細胞 / 膜蛋白質 / 質量分析 / ラベル化 / 血中循環細胞 / 抗原探索 / 抗体標的探索 / 抗体開発 / 抗体医薬品 / ビオチン化ラベル / ストレプトアビジン / 標的探索 / 抗体医薬 / RANK / 軟骨形成 / ペプチド / RANKL / 骨形成促進 / ゼラチンハイドロゲル / RANKL結合ペプチド / ラベリング法 / 骨形成 / 軟骨変性抑制 / argonaute 2 / 細胞内動態 / 核移行 / RNA干渉 / Argonaute 2 / reactive site / metastasis / invasion / serine protease inhibitor / breast cancer cell / Protein C inhibitor / 腎近位尿細管上皮細胞 / DNAメチル化 / 反応部位 / 浸潤 / CpGメチレーション / pro-inflammatory factor / transgenic mice / serpin / 肝再生 / 肝障害 / 種特異的臓器発現 / SERPIN / 特異的臓器発現 / 遺伝子メチル化 / 浸潤・転移 / セルピン / tissue factor / protein C receptor / thrombomodulin / adenosine receptor / aspirin / protein structure-function relationship / anti-thrombotic property / endothelium / cAMP / cGMP / NO産生酵素 / アデノシン / 細胞膜受容体 / 血管内皮細胞 / 組織因子 / プロテインC受容体 / アスピリン / アデノシン受容体 / 蛋白質構造・機能相関 / 抗血栓性因子 / molecular markers for tissue regeneration / protein chip-ELISA / inflammation / hepatocyte growth factor / Hepatocyte growth factor activator / liver regeneration / SAGE法 / プロテインチップ法 / ELISA / 肝細胞増殖因子活性化因子 / 肝細胞増殖因子 / 治療・診断法 / DNAマイクロアレイ / ゲノミクス / HGFA-PCI複合体 / 再生分子マーカー / 臓器移植 / 臓器再生 / Aminopeptidase P3 / Treg / 分子標的治療 / 医療・福祉 / aminopeptidase P3 / TNFR2 / TNF / バイオマーカー / 医療薬剤学 / 細胞・組織 / 共焦点顕微鏡 / ドラッグデリバリー / 薬物動態・代謝学 / 血管新生阻害 / 癌細胞の浸潤・転移阻害 / 癌細胞の増殖阻害 / 活性化プロテイン / リポポリサッカライド / 組織障害機構 / プロテオーム / トランスクリプトーム / プロテアーゼ受容体 / 感染症 / 遺伝子導入 / uPAインヒビター / 血栓止血因子 / 癌転移 / 癌浸潤 Less
  • Research Projects

    (32 results)
  • Research Products

    (94 results)
  • Co-Researchers

    (36 People)
  •  抗体のバイパラトピック化による細胞の内在化機能の付与Principal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
      Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Research on molecular mechanisms of biological regulatory functions by direct and indirect actions of functional food ingredients

    • Principal Investigator
      井上 順
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Tokyo University of Agriculture
  •  Efficient Drug Targeting by oncolytic virus-meidated tumor-specific expression of artificial receptors

    • Principal Investigator
      櫻井 文教
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Kindai University
  •  Development of an Efficient Method for Creating Bispecific Antibodies by MixingPrincipal Investigator

    • Principal Investigator
      Kamada Haruhiko
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Development of antibody design optimized for active targetingPrincipal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Identification of target molecules of functional food ingredients in the intestinal tract and analysis of their effects on the intestinal microflora

    • Principal Investigator
      Inoue Jun
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Tokyo University of Agriculture
  •  Development of molecular targeted drug using high-resolution epitope mapping: a novel therapeutic strategy for intraocular fibrotic scarring

    • Principal Investigator
      Nakamura Shinsuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Gifu Pharmaceutical University
  •  Design of metamorphosis antibody molecule for cancer treatment and diagnosisPrincipal Investigator

    • Principal Investigator
      Kamada Haruhiko
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Development of technology to search for novel antibody targets by proteomics specialized on the surface of circulating tumor cells

    • Principal Investigator
      Inoue Tsuyoshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 34020:Analytical chemistry-related
    • Research Institution
      Osaka University
  •  Study of the mechanism of functional food ingredients through the control of intestinal signals

    • Principal Investigator
      INOUE Jun
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Tokyo University of Agriculture
  •  A new drug development for accelerating bone and/or cartilage formation by RANK-like peptide

    • Principal Investigator
      HASEGAWA Nozomi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of new purification method of extracellular vesicles for cancer diagnosticsPrincipal Investigator

    • Principal Investigator
      Kamada Haruhiko
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Medical systems
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Elucidation of nuclear import mechanism of argonaute 2 for efficient knockdown of nuclear-localizing non-coding RNA

    • Principal Investigator
      SAKURAI FUMINORI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  Drug target discovery for autoimmune diseases by using a technology creating functional mutant proteins

    • Principal Investigator
      TSUNODA Shin-ichi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      独立行政法人医薬基盤研究所
  •  Molecular-based analysis of organ construction using proteomic analyisPrincipal Investigator

    • Principal Investigator
      KAMADA Haruhiko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Living organism molecular science
    • Research Institution
      独立行政法人医薬基盤研究所
  •  Creation of a new drug with a bispecific antibody against mesenchymal tissuePrincipal Investigator

    • Principal Investigator
      KAMADA Haruhiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Clinical oncology
    • Research Institution
      独立行政法人医薬基盤研究所
  •  Creation of functional mutant interferon-alpha for increase of bioactivity and decease of side-effectsPrincipal Investigator

    • Principal Investigator
      KAMADA Haruhiko
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      独立行政法人医薬基盤研究所
  •  Search for metastasis-related proteins in colorectal cancer by proteome analysis

    • Principal Investigator
      NAGANO Kazuya
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      独立行政法人医薬基盤研究所
  •  Development of discovering technology to quantify the biomarker for minimally invasive diagnostics.Principal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Biomedical Innovation
  •  An organelle targeting system as a next generation technology for drug development

    • Principal Investigator
      TSUNODA Shinichi
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      National Institute of Biomedical Innovation
  •  がんに対するTNF療法の最適化を目指した基盤技術の開発

    • Principal Investigator
      堤 康央
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Biomedical Innovation
  •  疾患関連蛋白質に対する網羅的一本鎖抗体ライブラリの作製と応用Principal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Medical pharmacy
    • Research Institution
      独立行政法人医薬基盤研究所
  •  分子進化戦略を用いた安全かつ有効な抗腫瘍サイトカインの創製とそのDDS

    • Principal Investigator
      TSUTSUMI Yasuo
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      独立行政法人医薬基盤研究所
  •  多機能SERPIN,プロテインCインヒビターによる癌細胞の浸潤・転移制御機構

    • Principal Investigator
      鈴木 宏治
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  血管病変の形成に及ぼすC反応性蛋白質の分子細胞機構の解明Principal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      独立行政法人医薬基盤研究所
      National Institute of Health Sciences
  •  Effect of protein C inhibitor on renal cell carcinogenesis and on tumor invasion, growth and metastasis

    • Principal Investigator
      HAYASHI Tatsuya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Mie University
  •  細胞膜プロテアーゼ受容体の活性化を介する感染宿主応答としての組織障害機構

    • Principal Investigator
      鈴木 宏治
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  細胞マイクロレオロジー測定装置を用いた静脈性血栓症の新規診断システムの開発Principal Investigator

    • Principal Investigator
      鎌田 春彦
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Mie University
  •  Molecular pathobiological studies on the multi-functional SERPIN, protein C inhibitor-dependent diseases

    • Principal Investigator
      SUZUKI Koji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Mie University
  •  癌細胞の浸潤・転移の制御調節に関わる血液凝固関連因子の分子細胞学的研究

    • Principal Investigator
      SUZUKI Koji
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Mie University
  •  Development of high sensitive assay method to detect tissue specific regeneration markers -Protein chip -ELISA specific for liver regeneration

    • Principal Investigator
      SUZUKI Koji
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Laboratory medicine
    • Research Institution
      Mie University
  •  Structure-function relationship of the endothelial cell membrane receptors playing in the anti-thrombotic properties.

    • Principal Investigator
      SUZUKI Koji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Mie University

All 2020 2017 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 臨床プロテオミクス~バイオマーカー探索から個別化医療へ2012

    • Author(s)
      鎌田春彦, ほか(共著)
    • Publisher
      金原出版株式会社
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Journal Article] A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification2017

    • Author(s)
      Masaki Inoue, Daisuke Ando, Haruhiko Kamada, Shintaro Taki, Mayumi Niiyama, Yohei Mukai, Takashi Tadokoro, Katsumi Maenaka, Taisuke Nakayama, Yuji Kado, Tsuyoshi Inoue, Yasuo Tsutsumi and Shin-ichi Tsunoda
    • Journal Title

      J. Biol. Chem.,

      Volume: in press Issue: 16 Pages: 235-237

    • DOI

      10.1074/jbc.m117.779686

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25282230, KAKENHI-PROJECT-15K12566, KAKENHI-PROJECT-16K18499, KAKENHI-PROJECT-16K18918
  • [Journal Article] Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD32015

    • Author(s)
      Haruhiko Kamada, Shintaro Taki, Kazuya Nagano, Masaki Inoue, Daisuke Ando, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 456 Issue: 4 Pages: 908-912

    • DOI

      10.1016/j.bbrc.2014.12.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J04578, KAKENHI-PROJECT-24680093, KAKENHI-PROJECT-26713007
  • [Journal Article] Development of New Biologics through Creation of a Functional Cytokine Mutant2015

    • Author(s)
      鎌田 春彦
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 135 Issue: 7 Pages: 843-849

    • DOI

      10.1248/yakushi.15-00007-1

    • NAID

      130005085762

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2015-07-01
    • Language
      Japanese
    • Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K12566
  • [Journal Article] Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.2013

    • Author(s)
      Nagano K, Kanasaki S, Yamashita T, Maeda Y, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S.
    • Journal Title

      Cancer Med.

      Volume: 2 Pages: 972-977

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Journal Article] Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer2012

    • Author(s)
      Yamashita T., Okamura T., Nagano K., Imai S., Abe Y., Nabeshi H., Yoshikawa T., Yoshioka Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Journal Title

      Pharmazie

      Volume: 67(3) Pages: 253-255

    • Data Source
      KAKENHI-PROJECT-23790216
  • [Journal Article] Arsenic trioxide induces down-regulation of gp46 via protein oxidation : proteomics analysis of oxidative modified proteins in As2O3-treated HTLV-1-infected cells.2010

    • Author(s)
      Nabeshi H., Kamada H., et al.
    • Journal Title

      Pharmazie

      Volume: 65 Pages: 702-707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV.2010

    • Author(s)
      Kayamuro H., Abe Y., Yoshioka Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Kawai Y., Mayumi T., Hiroi T., Itoh N., Nagano K., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 65(4)

      Pages: 254-6

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells.2010

    • Author(s)
      Nabeshi H., Yoshikawa T., Matsuyama K., Nakazato Y., Arimori A., Isobe M., Tochigi S., Kondoh S., Hirai T., Akase T., Yamashita T., Yamashita K., Yoshida T., Nagano K., Abe Y., Yoshioka Y., Kamada H., Imazawa T., Itoh N., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 65(3)

      Pages: 199-201

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.2010

    • Author(s)
      Yoshida T., Kamada H., et al.
    • Journal Title

      Toxicol.Lett.

      Volume: 199 Pages: 383-388

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1- or TNFR22010

    • Author(s)
      Shibata H., Kamada H., et al.
    • Journal Title

      Cytokine

      Volume: 50 Pages: 75-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Urban aerosol induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo.2010

    • Author(s)
      Yoshida T., Kamada H., et al.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 780-783

    • NAID

      130000248036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.2010

    • Author(s)
      Yoshida T., Yoshioka Y., Fujimura M., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Kayamuro H., Nabeshi H., Nagano K., Abe Y., Kamada H., Tsunoda S., Yoshikawa T., Itoh N., Tsutsumi Y.
    • Journal Title

      Toxicol.Lett. 199(3)

      Pages: 383-388

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.2010

    • Author(s)
      Nomura T., Kamada H., et al.
    • Journal Title

      Pharmazie

      Volume: 65 Pages: 93-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology.2010

    • Author(s)
      Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 65(2)

      Pages: 93-96

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] An in vitro method for screening anti-platelet agents using a microchannel array flow analyzer.2010

    • Author(s)
      Kamada H., Okamoto T., Hayashi T., Suzuki K.
    • Journal Title

      Biorheology 47(2)

      Pages: 153-161

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells.2010

    • Author(s)
      Nabeshi H., Kamada H., et al.
    • Journal Title

      Pharmazie

      Volume: 65 Pages: 199-201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.2010

    • Author(s)
      Kayamuro H., Yoshioka Y., Abe Y., Arita S., Katayama K., Nomura T., Yoshikawa T., Kubota-Koketsu R., Ikuta K., Okamoto S., Mori Y., Kunisawa J., Kiyono H., Itoh N., Nagano K., Kamada H., Tsutsumi Y., Tsunoda S.
    • Journal Title

      J.Virol. 84(24)

      Pages: 12703-12712

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Urban aerosol induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo.2010

    • Author(s)
      Yoshida T., Yoshioka Y., Fujimura M., Kayamuro H., Yamashita K., Higashisaka K., Nakanishi R., Morishita Y., Nabeshi H., Yamashita T., Muroi M., Tanamoto K., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Itoh N., Yoshikawa T., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biol.Pharm.Bull. 33(5)

      Pages: 780-3

    • NAID

      130000248036

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Mutant TNF-alpha, mTNF-K90R, is a novel mucosal vaccine adjuvant candidate against HIV.2010

    • Author(s)
      Kayamuro H., Kamada H., et al.
    • Journal Title

      Pharmazie

      Volume: 65 Pages: 254-256

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Arsenic trioxide alters expression and oxidative modification of the proteome in leukemic cells.2010

    • Author(s)
      Nabeshi H., Yoshikawa T., Kamada H., Shibata H., Sugita T., Abe Y., Nagano K., Nomura T., Minowa K., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 65

      Pages: 702-707

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The IL-1 family cytokines as mucosal vaccine adjuvant for the induction of protective immunity against influenza virus.2010

    • Author(s)
      Kayamuro H, Kamada H., et al.
    • Journal Title

      J.Virol

      Volume: 84 Pages: 12703-12712

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] In vivo biotinylation of the vasculature in B cell lymphoma identifies BST-2 as a target for antibody-based therapy.2010

    • Author(s)
      Schliemann C., Kamada H., et al.
    • Journal Title

      Blood

      Volume: 115 Pages: 736-744

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] In vivo biotinylation of the vasculature in B cell lymphoma identifies BST-2 as a target for antibody-based therapy.2010

    • Author(s)
      Schliemann C., Roesli C., Kamada H., Borgia B., Fugmann T., Klapper W., Neri D.
    • Journal Title

      Blood 115(3)

      Pages: 736-744

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape.2010

    • Author(s)
      Yamashita K., Kamada H., et al.
    • Journal Title

      Inflammation

      Volume: 33 Pages: 276-280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape.2010

    • Author(s)
      Yamashita K., Yoshioka Y., Higashisaka K., Morishita Y., Yoshida T., Fujimura M., Kayamuro H., Nabeshi H., Yamashita T., Nagano K., Abe Y., Kamada H., Kawai Y., Mayumi T., Yoshikawa T., Itoh N., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Inflammation 33(4)

      Pages: 276-80

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1- or TNFR2.2010

    • Author(s)
      Shibata H., Abe Y., Yoshioka Y., Nomura T., Sato M., Kayamuro H., Kawara T., Arita S., Furuya T., Nagano K., Yoshikawa T., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Cytokine 50(1)

      Pages: 75-83

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] An in vitro method for screening anti-platelet agents using a microchannel array flow analyzer.2010

    • Author(s)
      Kamada H., et al.
    • Journal Title

      Biorheology

      Volume: 47 Pages: 156-161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library.2009

    • Author(s)
      Nagano K., Kamada H., et. al
    • Journal Title

      Pharmazie 64

      Pages: 238-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Arsenic trioxide has the inhibitory effect on transmission of human T-cell leukemia virus type 12009

    • Author(s)
      Nabeshi H., Kamada H., et. al
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 1286-1288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains.2009

    • Author(s)
      Yoshikawa T., Kamada H., et.al
    • Journal Title

      Biomaterials 30

      Pages: 3318-3323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses.2009

    • Author(s)
      Kayamuro H., Kamada H., et. al
    • Journal Title

      Biomaterials 29

      Pages: 5869-5873

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The specific effect of 2-Methoxyestradiol on lymphatic vascular endothelial cells.2009

    • Author(s)
      Imai S., Yoshida Y., Okamura T., Nagano K., Abe Y., Yoshikawa T., Kamada H., Nakagawa S., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 64(3)

      Pages: 214-6

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Improved protein sequence coverage by on resin deglycosylation and cysteine modification for biomarker discovery.2009

    • Author(s)
      Kamada H., Fugmann T., et. al
    • Journal Title

      Proteomics 9

      Pages: 783-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF : useful information for designing artificial proteo-antagonists.2009

    • Author(s)
      Mukai Y., Kamada H., et. al
    • Journal Title

      J.Biochem 146

      Pages: 167-172

    • NAID

      10026302534

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF : useful information for designing artificial proteo-antagonists.2009

    • Author(s)
      Mukai Y., Nakamura T., Yoshioka Y., Shibata H., Abe Y., Nomura T., Taniai M., Ohta T., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y.
    • Journal Title

      J.Biochem. 146(2)

      Pages: 167-72

    • NAID

      10026302534

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Arsenic trioxide has the inhibitory effect on transmission of human T-cell leukemia virus type 1.2009

    • Author(s)
      Nabeshi H., Yoshikawa T., Kamada H., Shibata H., Sugita T., Abe Y., Nagano K., Nomura T., Minowa K., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biol.Pharm.Bull. 32(7)

      Pages: 1286-8

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses.2009

    • Author(s)
      Kayamuro H., Abe Y., Yoshioka Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Hiroi T., Itoh N., Kawai Y., Kamada H., Nagano K., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biomaterials 30(29)

      Pages: 5869-5876

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Crystallization and preliminary X-ray analysis of TNF-TNFR2 complex, Acta. Crystallogr.2009

    • Author(s)
      Mukai Y., Nakamura T., Yoshioka Y., Tsunoda S., Kamada H., Nakagawa S., Yamagata Y., Tsutsumi Y.
    • Journal Title

      Sect.F. 65(Pt3)

      Pages: 295-8

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.2009

    • Author(s)
      Shibata H., Yoshioka Y., Abe Y., Ohkawa A., Nomura T., Minowa K., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Kamada H., Tsutsumi Y.
    • Journal Title

      Biomaterials. 30(34)

      Pages: 6638-6647

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.2009

    • Author(s)
      Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biochem.Biophys.Res.Commun. 30;388(4)

      Pages: 667-71

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant.2009

    • Author(s)
      Kayamuro H., Yoshioka Y., Abe Y., Katayama K., Yoshida T., Yamashita K., Yoshikawa T., Hiroi T., Itoh N., Kawai Y., Mayumi T., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biochem.Biophys.Res.Commun. 384(3)

      Pages: 296-300

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF.2009

    • Author(s)
      Shibata H., Kamada H., et. al
    • Journal Title

      Biomaterials 30

      Pages: 6638-6647

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The specific effect of 2-Methoxyestradiol on lymphatic vascular endothelial cells.2009

    • Author(s)
      Imai S., Kamada H., et. al
    • Journal Title

      Pharmazie 64

      Pages: 214-216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Improved protein sequence coverage by on resin deglycosylation and cysteine modification for biomarker discovery.2009

    • Author(s)
      Kamada H., Fugmann T., Neri D., Roesli C.
    • Journal Title

      Proteomics 9(3)

      Pages: 783-787

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant.2009

    • Author(s)
      Mukai Y., Shibata H., Nakamura T., Yoshioka Y., Abe Y., Nomura T., Taniai M., Ohta T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y.
    • Journal Title

      J.Mol.Biol. 385

      Pages: 1221-1229

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Crystallization and preliminary X-ray analysis of TNF-TNFR2 complex.2009

    • Author(s)
      Mukai Y., Kamada H., et. al
    • Journal Title

      Acta.Crystallogr.Sect.F. 65(Pt.3)

      Pages: 295-298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] TNF superfamily member, TLIA, is a potential mucosal vaccine adjuvant.2009

    • Author(s)
      Kayamuro H., Kamada H., et.al
    • Journal Title

      Biochem.Biophys.Res.Commun. 384

      Pages: 296-300

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains.2009

    • Author(s)
      Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Shibata H., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biomaterials 30

      Pages: 3318-3323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790156
  • [Journal Article] Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.2009

    • Author(s)
      Nomura T., Kamada H., et. al
    • Journal Title

      Biochem.Biophys.Res.Commun. 388

      Pages: 667-671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Rapid isolation of intrabody candidates by using an optimized non-immune phage antibody library.2009

    • Author(s)
      Nagano K., Imai S., Mukai Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Pharmazie 64(4)

      Pages: 238-41

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] The augmentation of intracellular delivery of peptide therapeutics by artificial protein transduction domains.2009

    • Author(s)
      Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Shibata H., Yoshioka Y., Nakagawa S., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      Biomaterials. 30(19)

      Pages: 3318-23

    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR 1-selective TNF mutant.2009

    • Author(s)
      Mukai Y., Kamada H., et. al
    • Journal Title

      J.Mol.Biol. 385

      Pages: 1221-1229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Journal Article] Organelle-targeted delivery of biological macromolecules using the protein transduction domain: Potential applications for peptide aptamer delivery into the nucleus.2008

    • Author(s)
      Yoshikawa T., Sugita T., Mukai Y., Yamanada N., Nagano K., Nabeshi H., Yoshioka Y., Nakagawa S., Abe Y., Kamada H., Tsunoda S., Tsutsumi Y.
    • Journal Title

      J. Mol. Biol. 380

      Pages: 777-782

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790156
  • [Journal Article] Creation of mvel cell-penetrating peptides for intracellular drug delivery using systematic phagedisplay technology originated from Tat transduction domain2007

    • Author(s)
      Kamada H., et. al.
    • Journal Title

      Biol. Pharm. Bull. 30(2)

      Pages: 218-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18015055
  • [Journal Article] プロテオーム創薬からのDDS開発2006

    • Author(s)
      鎌田春彦 他
    • Journal Title

      最新医学 61(6)

      Pages: 73-79

    • Data Source
      KAKENHI-PROJECT-18015055
  • [Journal Article] In vitro evaluation of blood coagulation activation and microthrombus formation by a microchannel array flow analyzer.2004

    • Author(s)
      Kamada H., et al.
    • Journal Title

      Thromb Res. 114・3

      Pages: 195-203

    • Data Source
      KAKENHI-PROJECT-16790534
  • [Journal Article] Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.2004

    • Author(s)
      Kamada H., et al.
    • Journal Title

      Clin. Cancer Res. 10・7

      Pages: 2545-2550

    • Data Source
      KAKENHI-PROJECT-16790534
  • [Journal Article] Development of new anti-TNF therapy

    • Author(s)
      Kamada H., et al.
    • Journal Title

      炎症再生医学会誌 (印刷中)

    • NAID

      10022601894

    • Data Source
      KAKENHI-PROJECT-18015055
  • [Patent] 二重特異性抗体及び医薬組成物2012

    • Inventor(s)
      鎌田春彦、角田慎一
    • Industrial Property Rights Holder
      医薬基盤研究所
    • Industrial Property Number
      2013-033677
    • Filing Date
      2012-02-22
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] 機能エピトープの解析をベースにした抗体医薬設計2020

    • Author(s)
      鎌田春彦
    • Organizer
      第414回CBI学会講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19491
  • [Presentation] 心不全に対する新規診断法の開発に向けたバイオマーカーの探索.2017

    • Author(s)
      大須賀 絵理, 東阪 和馬, 笠原 淳平, 豊田 麻人, 鎌田春彦, 前田 真貴子, 長野 一也, 藤尾 慈, 坂田 泰史, 堤 康央
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      宮城(仙台)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15K12566
  • [Presentation] ヒトTNFR2指向性アゴニストを用いた新規TNFR2シグナル関連分子の同定2015

    • Author(s)
      鎌田 春彦,井上 雅己 ほか
    • Organizer
      日本プロテオーム学会 2015年会
    • Place of Presentation
      くまもと森都心プラザ,熊本
    • Year and Date
      2015-07-23
    • Data Source
      KAKENHI-PROJECT-15K12566
  • [Presentation] Identification of Adaptor ProtreinsIncludedin the TNFR2 Signaling Complex2015

    • Author(s)
      Haruhiko Kamada
    • Organizer
      14th Human Proteome Organization World Congress
    • Place of Presentation
      Vancouver Convention Centre, Vancouver
    • Year and Date
      2015-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12566
  • [Presentation] Phage display as a powerful tool for drug discovery2015

    • Author(s)
      Haruhiko Kamada
    • Organizer
      ETH seminar
    • Place of Presentation
      Swiss Federal Institutes of Technology in Zurich, Zurich
    • Year and Date
      2015-06-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K12566
  • [Presentation] 機能性サイトカイン変異体の創製による次世代バイオ医薬品の開発2014

    • Author(s)
      鎌田春彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390022
  • [Presentation] EphA10を創薬ターゲットとしてtandem scFV型Bispecific抗体の新規乳がん治療法の開発2014

    • Author(s)
      鎌田 春彦
    • Organizer
      新学術領域「がん研究分野の特性等を踏まえた研究支援活動」公開シンポジウム.
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] EphA10とCD3を認識する新規Bispecific抗体(EphA10/CD3)の創製とT細胞活性化に関する考察.2014

    • Author(s)
      瀧慎太郎, 鎌田春彦, 井上雅己, 長野一也, 向 洋平, 堤 康央, 角田慎一
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] 乳がん関連たんぱく質EphA10を標的としたtandem scFv型bispecific抗体の開発2013

    • Author(s)
      瀧慎太郎, 鎌田春彦, 井上雅己, 前田祐香, 長野一也, 向 洋平, 堤 康央, 角田慎一
    • Organizer
      第29回日本DDS学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] Evaluation of Eph receptor A10 as a novel drug target for breast cancer.2012

    • Author(s)
      前田祐香、鎌田春彦, 他
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌(北海道)
    • Year and Date
      2012-09-20
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] Exosome由来膜タンパク質のプロテオーム解析による新規肺がんバイオマーカーの探索2012

    • Author(s)
      山下琢矢,鎌田春彦, 他
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋(愛知)
    • Data Source
      KAKENHI-PROJECT-24651252
  • [Presentation] Expression of Rho GDP dissociation inhibitor correlates positively with lymph node metastasis in colorectal cancer2012

    • Author(s)
      Nagano K., Okamura T., Yamashita T., Kanasaki S., Maeda Y., Inoue M., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Organizer
      EACR-22
    • Place of Presentation
      Barcelona (Spain)
    • Data Source
      KAKENHI-PROJECT-23790216
  • [Presentation] 大腸がん転移診断・治療法の開発を目指した転移関連たんぱく質の探索2012

    • Author(s)
      長野一也, 岡村賢孝, 山下琢矢, 金崎聡一郎, 前田祐香, 古屋 剛, 井上雅己, 鍋師裕美, 吉川友章, 吉岡靖雄, 阿部康弘, 鎌田春彦, 堤 康央, 角田慎一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌(北海道)
    • Data Source
      KAKENHI-PROJECT-23790216
  • [Presentation] Exosome由来膜タンパク質のプロテオーム解析による新規肺がんバイオマーカーの探索2012

    • Author(s)
      山下琢矢, 鎌田春彦 他
    • Organizer
      第37回日本医用マススペクトル学会年会
    • Place of Presentation
      名古屋(愛知)
    • Data Source
      KAKENHI-PROJECT-24651252
  • [Presentation] がん細胞分泌エクソソームのプロテオーム解析によるバイオマーカー候補蛋白質の探索2012

    • Author(s)
      鎌田春彦, 他
    • Organizer
      日本プロテオーム機構第10回大会
    • Place of Presentation
      東京(東京)
    • Data Source
      KAKENHI-PROJECT-24651252
  • [Presentation] がん細胞分泌エクソソームのプロテオーム解析によるバイオマーカー候補蛋白質の探索.2012

    • Author(s)
      鎌田 春彦 他
    • Organizer
      日本プロテオーム機構 第10回大会
    • Place of Presentation
      東京(東京)
    • Data Source
      KAKENHI-PROJECT-24651252
  • [Presentation] Eph receptor A10を標的とした新規乳がん治療薬開発の試み2012

    • Author(s)
      前田祐香、鎌田春彦, 他
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      西宮(兵庫)
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] 新規乳がん分子標的治療薬の開発に向けたEph receptor A10に対するモノクローナル抗体の作2012

    • Author(s)
      前田祐香、鎌田春彦, 他
    • Organizer
      第28回日本DDS学会学術集会
    • Place of Presentation
      札幌(北海道)
    • Year and Date
      2012-07-04
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines.2011

    • Author(s)
      Yamashita T., Nagano K., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S.
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(愛知)
    • Data Source
      KAKENHI-PROJECT-23790216
  • [Presentation] 抗体工学を駆使した創薬ターゲットの探索技術2011

    • Author(s)
      鎌田春彦
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines2011

    • Author(s)
      Yamashita T., Nagano K., Yoshikawa T., Yoshioka Y., Itoh N., Abe Y., Kamada H., Tsutsumi Y., Tsunoda S
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋(愛知)
    • Data Source
      KAKENHI-PROJECT-23790216
  • [Presentation] イオンモビリティ質量分析装置を用いたバイオ医薬の安全性・品質評価法に関する基礎検討2011

    • Author(s)
      鎌田春彦, ほか
    • Organizer
      第9回日本ヒトプロテオーム機構学術集会
    • Place of Presentation
      新潟(新潟)
    • Year and Date
      2011-07-28
    • Data Source
      KAKENHI-PROJECT-23659061
  • [Presentation] イオンモビリティ質量分析装置を用いたバイオ医薬の安全性・品質評価法に関する基礎検討2011

    • Author(s)
      鎌田春彦, 他
    • Organizer
      第9回日本ヒトプロテオーム機構学術集会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-23659061
  • [Presentation] 抗体工学を駆使した創薬ターゲットの探索技術2011

    • Author(s)
      鎌田春彦
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法を用いた抗体医薬品の構造とその生物活性の変化に関する基礎検討2010

    • Author(s)
      鎌田春彦, など
    • Organizer
      第10回 日本蛋白質科学会
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法を用いた抗体医薬品の構造とその生物活性の変化に関する基礎検討2010

    • Author(s)
      鎌田春彦, 廣瀬賢治, 押方基二, 佐藤太, 長野一也, 阿部康弘, 堤康央, 角田慎一
    • Organizer
      第10回日本蛋白質科学会
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法による蛋白質医薬品の構造と活性の連関解析2009

    • Author(s)
      鎌田春彦, 廣瀬賢治, 阿部康弘, 角田慎一, 堤康央
    • Organizer
      第57回日本質量分析総合討論会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法を用いた蛋白質医薬品の品質管理に向けた基礎検討2009

    • Author(s)
      鎌田春彦, 廣瀬賢治, 阿部康弘, 角田慎一, 堤康央
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法を用いた蛋白質医薬品の品質管理に向けた基礎検討.2009

    • Author(s)
      鎌田春彦, ら
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] イオンモビリティー質量分析法による蛋白質医薬品の構造と活性の連関解析.2009

    • Author(s)
      鎌田春彦, ら
    • Organizer
      第57回日本質量分析総合討論会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-13
    • Data Source
      KAKENHI-PROJECT-21790173
  • [Presentation] TNFR2のシグナル伝達解明に向けたヒトTNFR2指向性変異体の創製とその応用

    • Author(s)
      鎌田春彦、角田慎一ほか
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-24390022
  • [Presentation] 抗腫瘍活性の向上にむけたBispecific抗体の最適化.

    • Author(s)
      瀧慎太郎, 鎌田春彦, 長野一也, 向 洋平, 堤 康央, 角田慎一
    • Organizer
      第13回次世代を担う若手ファーマ・バイオフォーラム2014
    • Place of Presentation
      富山(富山)
    • Year and Date
      2014-09-20 – 2014-09-21
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] 難治性乳がんをターゲットとする新規Bispecific抗体(EphA10/CD3)の創製.

    • Author(s)
      瀧慎太郎, 鎌田春彦, 井上雅己, 長野一也, 向 洋平, 堤 康央, 角田慎一
    • Organizer
      第18回日本がん分子標的治療学会学術集会.
    • Place of Presentation
      仙台(宮城)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-24680093
  • [Presentation] Optimization of bispecific antibody targeting CD3 and EphA10 as a bio-drug candidate against breast cancer.

    • Author(s)
      Taki S., Kamada H., Inoue M., Nagano K., Mukai Y., Tsutsumi Y., Tsunoda S.
    • Organizer
      The 19th JFCR-ISCC
    • Place of Presentation
      Tokyo (Tokyo)
    • Year and Date
      2014-12-10 – 2014-12-11
    • Data Source
      KAKENHI-PROJECT-24680093
  • 1.  SUZUKI Koji (70077808)
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  • 2.  HAYASHI Tatsuya (00242959)
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