HASHITANI Susumu 橋谷進

Researcher Number	00330449
Other IDs
Affiliation (based on the past Project Information) *help	2011: 兵庫医科大学, 医学部, 助教 2007 – 2009: Hyogo College of Medicine, Faculty of Medicine, Instructor 2003 – 2006: 兵庫医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry Except Principal Investigator Surgical dentistry / Periodontal dentistry
Keywords	Principal Investigator 腺様嚢胞癌 / 組織型 / ヌードマウス / 転移 / ヌードマウス継代移植 / ヌードマウス移植継代株 Except Principal Investigator 口腔癌 / IL-22 / 予後 / 転移 … More / 浸潤 / keratinocytes / T cells / β-defensin / periodontitis / β-ディフェンシン2,3 / ケラチノサイト / T細胞 / β-ディフェンシン / 歯周炎 / COX-2 inhibitor / hamster cheek pouch carcinogenesis / nude mouse transplantation model / metalloproteinases / prognostic factor / invasion and matastasis / cyclooxygenase (COX)-2 / oral cancer / シスプラチン感受性 / in vitro浸潤能 / DNA-トポイソメラーゼIIα / 腫瘍増殖抑制 / MMP / COX-2高発現KB細胞 / COX-2阻害剤 / ハムスター頬嚢化学発癌 / ヌードマウス移植モデル / メタロプロテナーゼ / 予後因子 / 浸潤・転移 / シクロオキシゲナーゼ(COX)-2 / 浩腫瘍性 / 免疫組織化学 / 上皮・間葉移行 / 抗癌剤耐性 / 造腫瘍性 / 細胞培養 / 癌幹細胞 / 臨床腫瘍学 / CXCR4 / ケモカインレセプター / 腺様嚢胞癌 Less

Isolation and identification of oral cancer stem cells and development of specific therapy for cancer stem cells
- Principal Investigator
  
  URADE Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo Medical University
Analysis of the metastasis mechanism and inhibition of the high metastatic potential nude mouse transplantable model of a human adenoid cystic carcinomaPrincipal Investigator
- Principal Investigator
  
  HASHITANI Susumu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo College of Medicine
Analysis of mechanisms of oral cancer metastasis via chemokine signals and molecular target therapy for inhibition of metastasis
- Principal Investigator
  
  URADE Masahiro
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo College of Medicine
A study for the involvement of IL-22 in the pathogenesis of periodontal diseases
- Principal Investigator
  
  OHYAMA Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hyogo College of Medicine
腺様嚢胞癌のヌードマウス移植継代株における組織型別での遺伝子発現に関する研究Principal Investigator
- Principal Investigator
  
  橋谷進
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo Medical University
腺様嚢胞癌のヌードマウス移植継代株における組織型と悪性度の関連性に関する研究Principal Investigator
- Principal Investigator
  
  橋谷進
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo Medical University
Investigation for involvement of COX-2 in invasion and metastasis of oral cancer and inhibitory effect by selective COX-2 inhibitors
- Principal Investigator
  
  URADE MASAHIRO
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo College of Medicine

All 2011 2010 2008 2007 2006 2005 2003

All Journal Article Presentation

[Journal Article] Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-22010
- Author(s)
  Nao Ohtsu, Kazuki Takaoka, Emi Segawa, Susumu Hashitani, Kazuma Noguchi, HiromitsuKishimoto, Masahiro Urade
- Journal Title
  
  Oncol Rep
  
  Volume: 24 Issue: 1 Pages: 31-36
- DOI
  10.3892/or_00000825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390544, KAKENHI-PROJECT-21592549, KAKENHI-PROJECT-22592248
[Journal Article] Promotion of hematogeneous metastatic potentials in human KB carcinoma cells with overexpression of cyclooxygenase-22010
- Author(s)
  Emi Segawa, Hiromitsu Kishimoto, Kazuki Takaoka, Kazuma Noguchi, Susumu Hashitani, Kazunari Sakurai, Masahiro Urade
- Journal Title
  
  Oncol Rep
  
  Volume: 24 Issue: 3 Pages: 733-739
- DOI
  10.3892/or_00000915
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390544
[Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck2008
- Author(s)
  ZUSHI Y, NOGUCHI K, HASHITANI S, SAKURAI K, SEGAWA E, TAKAOKA K, TOYOHARA Y, TANAKA N, KISHIMOTO H and URADE M,
- Journal Title
  
  International Journal of Oncology 33
  
  Pages: 1133-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592343
[Journal Article] Expression of cyclooxygenase-2 and DNA topoisomerase II α in precancerous and cancerous lesions of the oral mucosa.2008
- Author(s)
  Segawa E, Sakurai K, Kishimoto H, Takaoka K, Noguchi K, Hashitani S, Hirota S, Urade M.
- Journal Title
  
  Oral Oncol 44
  
  Pages: 664-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA.2008
- Author(s)
  Takaoka K, Kishimoto H, Segawa E, Otsu N, Zushi Y, Hashitani S, Noguchi K, Urade M.
- Journal Title
  
  Oncol Rep 20
  
  Pages: 645-649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung.2008
- Author(s)
  Maeda T, Hashitani S, Zushi Y, Segawa E, Tanaka N, Sakurai K, Urade M.
- Journal Title
  
  J Cancer Res Clin 134
  
  Pages: 1005-1011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck2008
- Author(s)
  Zushi Y, Noguchi K, Hashitani S, etc.
- Journal Title
  
  International Journal of Oncology 33
  
  Pages: 1133-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592343
[Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastases to lymph node and lung.2007
- Author(s)
  Hashitani S, Urade M, Zushi Y, Sagawa E, Okui S, Sakurai K.
- Journal Title
  
  Oncol Rep 17
  
  Pages: 67-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung2007
- Author(s)
  Susumu Hashitani, et al.
- Journal Title
  
  Oncology Reports 17・1
  
  Pages: 67-72
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Prognostic significance of cyclooxygenase-2 and DNA topoisomerase II α expression in oral carcinoma.2007
- Author(s)
  Sakurai K, Urade M, Noguchi K, Hashitani S, Takaoka K, Segawa E, Kishimoto H.
- Journal Title
  
  Head Neck 29
  
  Pages: 1002-1009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastasis to the lymph node and lung2007
- Author(s)
  Hashitani S, et al.
- Journal Title
  
  Oncology Reports 17・1
  
  Pages: 67-72
- Data Source
  KAKENHI-PROJECT-17791503
[Journal Article] Establishment and characterization of a human adenoid cystic carcinoma cell line forming colonies cultured in collagen gel and transplantable in nude mice.2007
- Author(s)
  Tanaka N, Urabe K, Hashitani S, Sakurai K, Urade M.
- Journal Title
  
  Oncol Rep 17
  
  Pages: 335-340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA.2006
- Author(s)
  Takaoka K, Kishimoto H, Segawa E, Hashitani S, Zushi Y, Noguchi K, Sakurai K, Urade M.
- Journal Title
  
  Int J Oncol 29
  
  Pages: 1095-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390549
[Journal Article] Changes of histological and biological features by serial passages in a human adenoid cystic carcinoma line transplantable in nude mice2005
- Author(s)
  Hashitani S.et al.
- Journal Title
  
  Oncology Reports 13・4
  
  Pages: 607-612
- Data Source
  KAKENHI-PROJECT-15791195
[Journal Article] Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective COX-2 inhibitor, in head and neck carcinoma cell lines.2003
- Author(s)
  Susumu Hashitani, et al.
- Journal Title
  
  Int.J.Oncol. 23
  
  Pages: 665-672
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390630
[Journal Article] Apoptosis imduction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective COX-2 inhibitor,in human head and neck carcinoma cell lines.2003
- Author(s)
  Susumu Hashitani, et al.
- Journal Title
  
  Int.J.Oncol. 23
  
  Pages: 665-672
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390630
[Presentation] Effect of NOS inhibitors and CXCR4 antagonist on tumor growth and metastasis of human adenoid cystic carcinoma xenografted into nude mice2011
- Author(s)
  Kazuki Takaoka, Sayaka Hidaka, Sususmu Hashitani, Yusuke Zushi, Michiyo Yamamura, Emi Segawa, Kazuma Noguchi, Hiromitsu Kishimoto, Masahiro Urade
- Organizer
  20^<th> International Conference on Oral and Maxillofacial Surgery
- Place of Presentation
  Santiago, Chile
- Year and Date
  2011-11-02
- Data Source
  KAKENHI-PROJECT-21390544
[Presentation] 口腔癌細胞におけるEMT markerとしてのzyxinの発現2010
- Author(s)
  瀬川英美、野口一馬、山村倫世、高岡一樹、頭司雄介、岸本裕充、橋谷進、浦出雅裕
- Organizer
  第55回(社)日本口腔外科学会学術大会
- Place of Presentation
  千葉
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21390544
[Presentation] 高転移能を有するマウス未分化癌に対するCXCR4拮抗剤とNOS阻害剤の腫瘍増殖および手に抑制効果2010
- Author(s)
  日高沙弥香、橋谷進、頭司雄介、田中徳昭、高岡一樹、浦出雅裕
- Organizer
  第64回NPO法人日本口腔科学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21390544
[Presentation] ヌードマウス心腔内移植におけるCOX-2高発現ヒトKB癌細胞の転移能およびsiRNA による転移抑制効果2008
- Author(s)
  瀬川英美、岸本裕充、高岡一樹、橋谷進、野口一馬、浦出雅裕
- Organizer
  第32回日本口腔科学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] Prognostic significance of cyclooxygenase-2 in oral cancer2008
- Author(s)
  Urade M, Kishimoto H, Takaoka K, Segawa E, Noguchi K, Hashitani S, Sakurai K
- Organizer
  XIX Congress of the European Association for Cranio-Maxillo-Facial Surgery
- Place of Presentation
  Bologna, Italy)
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] Establishment and characterization of a human malignant fibrous histiocytoma of the mandible transplantable in nude mice.2007
- Author(s)
  Hashitani S, Toyohara Y, Takaoka K, Noguchi K, Kishimoto H, Sakurai K, Urade M
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] Relationship between expression of CXCR4 and histological type in adenoid cysticcarcinoma of the head and neck2007
- Author(s)
  Zushi Y, Noguchi K, Hashitani S, Sakurai K, Takaoka K, Tanaka N, Kishimoto H, Urade M
- Organizer
  14th the European Cancer Conference(ECCO)
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-19592343
[Presentation] Relationship between expression of CXCR4 and histological type in adenoid cystic carcinoma of the head and neck2007
- Author(s)
  Zushi Y, Noguchi K, Hashitani S, Sakurai K, Takaoka K, Tanaka N, Kishimoto H, Urade M
- Organizer
  14th the European Cancer Conference (ECCO)
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-19592343
[Presentation] In vitro susceptibility to anticancer agents of human KB carcinoma cell line transfected with COX-2 cDNA.2007
- Author(s)
  Takaoka K, Urade M, Kishimoto H, Hashitani S, Toyohara Y, Noguchi K
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma showing metastases to the lymph node and lung.2006
- Author(s)
  Hashitani S, Noguchi K, Zushi Y, Okui S, Tanaka N, Sakurai K, Urade M.
- Organizer
  7^<th> Asian Congress on Oral and Maxillofacial Surgery
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] COX-2遺伝子導入によるヒトKB癌細胞の増殖能と浸潤能の亢進2006
- Author(s)
  高岡一樹、浦出雅裕、岸本裕充、橋谷進、豊原幸代、野口一馬、櫻井一成
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] ヌードマウス可移植性ヒト腺様嚢胞癌の移植継代による転移モデルの樹立2006
- Author(s)
  橋谷進、野口一馬、奥井森、瀬川英美、頭司雄介、櫻井一成、浦出雅裕
- Organizer
  第60回日本口腔科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] 3次元培養可能な腺様嚢胞癌細胞株の樹立とその細胞特性について2006
- Author(s)
  田中徳昭、占部一彦、橋谷進、櫻井一成、浦出雅裕
- Organizer
  第60回日本口腔科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] COX-2高発現ヒトKB癌細胞の増殖および浸潤能における一酸化窒素の影響2006
- Author(s)
  高岡一樹、岸本裕充、瀬川英美、頭司雄介、萬野幸代、橋谷進、野口一馬、櫻井一成、浦出雅裕
- Organizer
  第60回日本口腔科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] ヒト口底腺様嚢胞癌のヌードマウスにおける転移モデルの樹立とその細胞生物学的特性2006
- Author(s)
  橋谷進、野口一馬、豊原幸代、高岡一樹、岸本裕充、櫻井一成、浦出雅裕
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390549
[Presentation] 3次元培養可能な上顎腺様嚢胞癌由来培養細胞株の細胞特性2006
- Author(s)
  田中徳昭、橋谷進、櫻井一成、浦出雅裕
- Organizer
  第43回日本口腔組織培養学会
- Place of Presentation
  大阪
- Year and Date
  2006-11-11
- Data Source
  KAKENHI-PROJECT-18390549

1. URADE Masahiro (70104883)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
2. SAKURAI Kazunari (30129118)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. KISHIMOTO Hiromitsu (30291818)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. NOGUCHI Kazuma (50309473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
5. SEGAWA Emi (00553778)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. ZUSHI Yuusuke (80581206)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. TAKAOKA Kazuki (60373122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. TANAKA Noriaki (70412012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. NISHIMURA NORIHIKO (90330448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHYAMA Hideki (90280685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TERADA Nobuyuki (50150339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKASHO Keiji (00217712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMADA Naoko (10319858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NISHIMURA Fusanori (80208222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIROMOTO Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMAMURA Michiyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

HASHITANI Susumu 橋谷 進

Research Projects

Research Products

Co-Researchers

Isolation and identification of oral cancer stem cells and development of specific therapy for cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the metastasis mechanism and inhibition of the high metastatic potential nude mouse transplantable model of a human adenoid cystic carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanisms of oral cancer metastasis via chemokine signals and molecular target therapy for inhibition of metastasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study for the involvement of IL-22 in the pathogenesis of periodontal diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腺様嚢胞癌のヌードマウス移植継代株における組織型別での遺伝子発現に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腺様嚢胞癌のヌードマウス移植継代株における組織型と悪性度の関連性に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for involvement of COX-2 in invasion and metastasis of oral cancer and inhibitory effect by selective COX-2 inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-22010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Promotion of hematogeneous metastatic potentials in human KB carcinoma cells with overexpression of cyclooxygenase-22010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck2008

Author(s)

Journal Title

Data Source

[Journal Article] Expression of cyclooxygenase-2 and DNA topoisomerase II α in precancerous and cancerous lesions of the oral mucosa.2008

Author(s)

Journal Title

Data Source

[Journal Article] In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA.2008

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung.2008

Author(s)

Journal Title

Data Source

[Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of the head and neck2008

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of nude mouse transplantable model of a human adenoid cystic carcinoma of the oral floor showing metastases to lymph node and lung.2007

Author(s)

Journal Title

Data Source

HASHITANI Susumu 橋谷進