ITO Kosei 伊藤公成

… Alternative Names

Researcher Number	00332726
Other IDs
Affiliation (Current)	2020: 長崎大学, 医歯薬学総合研究科(歯学系), 教授
Affiliation (based on the past Project Information) *help	2014 – 2020: 長崎大学, 医歯薬学総合研究科(歯学系), 教授 2011: Nagasaki University, 医歯(薬)学総合研究科, 准教授 2010: 長崎大学, 医歯薬学総合研究科, 准教授 2001: Institute for Virus Research, Department of Viral Oncology, KYOTO UNIVERSITY Instructor, ウイルス研究所, 助手
Review Section/Research Field	Principal Investigator Carcinogenesis / Tumor biology / Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 57:Oral science and related fields Except Principal Investigator Biological Sciences / Morphological basic dentistry / 広領域 / Orthodontics/Pediatric dentistry
Keywords	Principal Investigator RUNX3 / p53 / c-Myc / Runx3 / 骨肉腫 / Runx / Wnt / 胃がん / SPEM / Cdx2 … More Except Principal Investigator RUNX2 / RUNX3 / Runx3 / TGF-β / trkC / pathfinding / RUNX1 / 16染色体逆位 / 急性骨髄性白血病 / 胃がん / がん制御遺伝子 / DNAメチル化 / ユビキチン / プロテアソーム / AML1 / PEBP2β / inv(16)キメラ / TUNEL / 腺胃上皮細胞 / Runx2 / エンハンサー / 骨芽細胞 / 転写制御 / 間葉系幹細胞 / Dlx5 / Mef2 / クロマチン修飾 / トランスジェニックマウス / FGF / Wnt / Tcf7 / 骨格形成 / 軟骨細胞 / 転写因子 / 胃上皮細胞 / アポトーシス / Igクラススイッチ / CD4サイレンサー / RUNXl / 自己複製能 / 腺胃細胞 / カスパーゼ / 筋原細胞C2C12 / PEBP2αA / Smad1 / BMP / アルカリフォスターゼ / gastric epithelial cells / apoptosis / Ig class switching / CD4 silencing / 咀嚼 / 摂食障害 / 神経伝達物質 / 顎運動 / 筋活動 / 筋電図 / ６自由度 / 嚥下 / 舌運動 / 顎口腔機能解析 / 摂食機能 / 顎口腔機能 Less

p53欠損腫瘍発症にエッセンシャルなゲノム上の特定配列Principal InvestigatorOngoing
- Principal Investigator
  
  伊藤公成
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Nagasaki University
RUNX転写因子の作用機序をターゲットにした革新的骨肉腫治療戦略の創出Principal InvestigatorOngoing
- Principal Investigator
  
  伊藤公成
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nagasaki University
Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy
- Principal Investigator
  
  YOSHIDA Noriaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Nagasaki University
Study of Osteosarcomagenesis using Genetically-Modified Mouse ModelsPrincipal Investigator
- Principal Investigator
  
  ITO Kosei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Nagasaki University
The mechanism of transcriptional regulation of Runx2 gene and the program of skeletal development
- Principal Investigator
  
  KOMORI Toshihisa
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
胃がん幹細胞マーカーの同定とそれを利用した解析用マウスモデルの作出Principal Investigator
- Principal Investigator
  
  伊藤公成
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Nagasaki University
転写因子PEBP2による発がん分子機構の研究
- Principal Investigator
  
  ITO Yoshiaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of a tissue specific master regulator, PEBP2
- Principal Investigator
  
  ITO Yoshiaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  KYOTO UNIVRSITY

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.2020
- Author(s)
  Date Y and Ito K
- Journal Title
  
  Molecules and Cells
  
  Volume: 43 Pages: 176-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02972
[Journal Article] Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.2020
- Author(s)
  Date Y and Ito K
- Journal Title
  
  Molecules and Cells
  
  Volume: 43 Pages: 176-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22724
[Journal Article] Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats2018
- Author(s)
  Ino-Kondo Airi、Hotokezaka Hitoshi、Kondo Takanobu、Arizono Keira、Hashimoto Megumi、Hotokezaka Yuka、Kurohama Takeshi、Morita Yukiko、Yoshida Noriaki
- Journal Title
  
  Angle Orthod
  
  Volume: - Pages: 474-482
- DOI
  10.2319/112017-801.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05050, KAKENHI-PROJECT-15K20602, KAKENHI-PROJECT-16K15840
[Journal Article] Roles of RUNX in solid tumors.2017
- Author(s)
  Chuang LSH, Ito K, Ito Y.
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 962 Pages: 299-320
- DOI
  10.1007/978-981-10-3233-2_19
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290040
[Journal Article] Types of tooth movement, bodily or tipping, do not affect the displacement of the tooth’s center of resistance but do affect the alveolar bone resorption.2017
- Author(s)
  Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
- Journal Title
  
  Angle Orthod
  
  Volume: 38 Pages: 563-569
- DOI
  10.2319/110416-794.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05050, KAKENHI-PROJECT-16K15840, KAKENHI-PROJECT-17K17335, KAKENHI-PROJECT-15K20600
[Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2017
- Author(s)
  Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
- Journal Title
  
  The European Journal of Orthodontics
  
  Volume: 38 Pages: 277-286
- DOI
  10.1093/ejo/cjw038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15840, KAKENHI-PROJECT-15H05050
[Journal Article] Cbfb2 isoform dominates more potent Cbfb1 and is required for skeletal development.2016
- Author(s)
  Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 印刷中 Pages: 1391-1404
- DOI
  10.1002/jbmr.2814
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11048, KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-26221310, KAKENHI-PROJECT-26290040, KAKENHI-PROJECT-16K15781, KAKENHI-PROJECT-16K20422
[Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015
- Author(s)
  Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 30 Pages: 706-14
- DOI
  10.1002/jbmr.2379
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25861748, KAKENHI-PUBLICLY-26114720, KAKENHI-PROJECT-26253084, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-15K11016, KAKENHI-PROJECT-15K11048, KAKENHI-PROJECT-15K20364, KAKENHI-PROJECT-26670811, KAKENHI-PROJECT-26290040, KAKENHI-PROJECT-26221310
[Journal Article] Central role of core binding factor beta2 in mucosa-associated lymphoid tissue organogenesis in mouse2015
- Author(s)
  T. Nagatake, S. Fukuyama, S. Sato, H. Okura, M. Tachibana, I. Taniuchi, K. Ito, M. Shimojou, N. Matsumoto, H, Suzuki, J. Kunisawa, and H. Kiyono
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0127460
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18950, KAKENHI-PROJECT-15K19142, KAKENHI-PROJECT-26290040, KAKENHI-PROJECT-26293109
[Journal Article] Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells.2014
- Author(s)
  Ju X, Ishikawa T, Naka K, Ito K, Ito Y, Oshima M.
- Journal Title
  
  Cancer Science
  
  Volume: 105 Pages: 418-424
- DOI
  10.1111/cas.12356
- NAID
  120005438970
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22114005, KAKENHI-PROJECT-24300325, KAKENHI-PROJECT-26290040
[Journal Article] Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements2014
- Author(s)
  Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: - Pages: 2953-2967
- DOI
  10.1093/hmg/ddu007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22249062, KAKENHI-PROJECT-24659829, KAKENHI-PROJECT-25293070, KAKENHI-PROJECT-25460326, KAKENHI-PROJECT-25670142
[Journal Article] Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation.2014
- Author(s)
  Ito K, Maruyama Z, Sakai A, Izumi S, Moriishi T, Yoshida CA, Miyazaki T, Komori H, Takada K, Kawaguchi H, Komori T.
- Journal Title
  
  Oncogene
  
  Volume: 33 Pages: 1862-1871
- DOI
  10.1038/onc.2013.130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249062, KAKENHI-PROJECT-24659829, KAKENHI-PROJECT-26290040
[Journal Article] Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53dependent apoptosis without enhancing proliferation2013
- Author(s)
  Ito K, Maruyama Z, Sakai A, Izumi S, Moriishi T, Yoshida CA, Miyazaki T, Komori H, Takada K, Kawaguchi H, Komori T
- Journal Title
  
  Oncogene
  
  Volume: Vol.33 Pages: 1862-1871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249062
[Journal Article] Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading.2012
- Author(s)
  Moriishi T, Fukuyama R, Ito M, Miyazaki T, Maeno T, Kawai Y, Komori H, Komori T
- Journal Title
  
  PLoS One
  
  Volume: 7(6) Pages: 40143-40143
- DOI
  10.1371/journal.pone.0040143
- NAID
  120004919744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249062, KAKENHI-PROJECT-24659829
[Journal Article] Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation2011
- Author(s)
  Mikasa M, Rokutanda S, Komori H, Ito K, Tsang YS, Date Y, Yoshida CA, Komori T
- Journal Title
  
  J Bone Miner Metab
  
  Volume: Vol.29 Pages: 291-299
- NAID
  10029024664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249062
[Patent] がん遺伝子の転写調節領域2018
- Inventor(s)
  伊藤公成
- Industrial Property Rights Holder
  伊藤公成
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] mR1 is an essential genomic element for p53-deficient osteosarcomagenesis.2019
- Author(s)
  伊達悠貴，大谷昇平，伊藤公成
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22724
[Presentation] Oncogenic Runx3 in osteosarcoma development.2019
- Author(s)
  Kosei Ito
- Organizer
  第22回 International RUNX Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22724
[Presentation] p53 represses c-Myc by inhibition of Runx3 to suppress osteosarcoma development.2019
- Author(s)
  大谷昇平，伊達悠貴，伊藤公成
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K22724
[Presentation] p53 represses c-Myc by inhibition of Runx3 to suppress osteosarcoma development.2019
- Author(s)
  大谷昇平，伊達悠貴，伊藤公成
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] mR1 is an essential genomic element for p53-deficient osteosarcomagenesis.2019
- Author(s)
  伊達悠貴，大谷昇平，伊藤公成
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] Oncogenic Runx3 in osteosarcoma development.2019
- Author(s)
  Kosei Ito
- Organizer
  第22回 International RUNX conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] 骨肉腫発症におけるがん遺伝子RUNX3の役割2018
- Author(s)
  伊藤公成
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] がん遺伝子RUNX3は骨肉腫発症においてC/ebpαの発現を抑制する2018
- Author(s)
  大森景介、伊達悠貴、大谷昇平、伊藤公成
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] TGF-β upregulates Runx3 to promote osteosarcomagenesis2018
- Author(s)
  上野智也、伊達悠貴、伊藤公成
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] 骨肉腫発症におけるRUNX転写因子の役割2018
- Author(s)
  伊藤公成
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02972
[Presentation] がん抑制遺伝子RUNX3の点変異体RUNX(R122C)は、胃上皮細胞においてWntによるがん化シグナルを抑制できない2010
- Author(s)
  伊藤公成
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22300319
[Presentation] RUNX3(R122C) does not attenuate oncogenic Wnt in gastric epithelial cells.2010
- Author(s)
  伊藤公成
- Organizer
  International RUNX-2010 Meeting
- Place of Presentation
  オリエンタルホテル(広島)
- Year and Date
  2010-07-11
- Data Source
  KAKENHI-PROJECT-22300319
[Presentation] RUNX3のがん抑制遺伝子としての機能2010
- Author(s)
  伊藤公成
- Organizer
  金沢大学がん研究所・オンコロジーセミナー
- Place of Presentation
  金沢大学がん研究所(金沢)
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22300319

1. ITO Yoshiaki (80004612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KOMORI Toshihisa (00252677)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. HAYASHI Hideki (10218589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MASUYAMA Ritsuko (60297596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIYAZAKI Toshihiro (10174161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. MORIISHI Takeshi (20380983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. SHIGESADA Katsuya (40009626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIDA Noriaki (40230750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 古賀義之 (50175329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤下あゆみ (30755723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 吉見知子 (20805973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 井上富雄 (70184760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中村文 (50711959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 内海大 (80622604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. FUKAMACHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 阪倉長平

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ROKUTANDA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. OSHIMA Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. OMORI Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. TERADA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 谷内一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. 川根徹也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 河井洋祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 石川智夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 大島正伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 鈴木英彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 長竹貴広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 古川貴久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 富永淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 小守寿人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 森田幸子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ITO Kosei 伊藤 公成

伊藤 公成 イトウ コウセイ

Research Projects

Research Products

Co-Researchers

p53欠損腫瘍発症にエッセンシャルなゲノム上の特定配列Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

RUNX転写因子の作用機序をターゲットにした革新的骨肉腫治療戦略の創出Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation into etiology and pathology of eating disorder caused by neurotransmitter disorders and its treatment strategy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Osteosarcomagenesis using Genetically-Modified Mouse ModelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of transcriptional regulation of Runx2 gene and the program of skeletal development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胃がん幹細胞マーカーの同定とそれを利用した解析用マウスモデルの作出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転写因子PEBP2による発がん分子機構の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of a tissue specific master regulator, PEBP2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.2020

Author(s)

Journal Title

Data Source

[Journal Article] Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation.2020

Author(s)

Journal Title

Data Source

[Journal Article] Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of RUNX in solid tumors.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Types of tooth movement, bodily or tipping, do not affect the displacement of the tooth’s center of resistance but do affect the alveolar bone resorption.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2017

Author(s)

Journal Title

DOI

ITO Kosei 伊藤公成

伊藤公成イトウコウセイ