MIKI Takayuki 三木隆幸

… Alternative Names

三木隆幸ミキタカユキ

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Researcher Number	00336405
Other IDs
Affiliation (Current)	2022: 札幌医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 札幌医科大学, 医学部, 准教授 2012 – 2016: 札幌医科大学, 医学部, 准教授 2007 – 2011: Sapporo Medical University, 2^<nd> Dept. of Internal Medicine, Assistant Professor 2001 – 2006: 札幌医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator プレコンディショニング / スタニング / PKC-ε / AMP kinase / GLUT4 / 梗塞後心室リモデリング / プレコンデイショング Except Principal Investigator 細胞死 / signal transduction / 細胞内情報伝達 … More / mitochondria / gap junction / コネキシン / cell death / connexin / protein kinase / preconditioning / 心筋細胞 / ミトコンドリア / necroptosis / autophagy / ネクロプトーシス / オートファジー / ギャップ結合 / protein kinase C / ischemia / myocardial infarction / 細胞シグナル / connexin-43 / G protein coupled receptor / β-subunit / 細胞内情報電達 / 活性酸素 / 透過性遷移孔 / ミトコンドリア透過性遷移孔 / グリコーゲン合成酵素キナーゼ3beta / グリコーゲン合成酵素キナーゼ3β / GSK-3β / 心筋虚血 / Cキナーゼ / myocardial ischemia / MAP kinase / ATP-sensitive K+ channel / ATP-sensitive potassium channel / コネキシン43 / 蛋白キナーゼ / 虚血障害 / プレコンディショニング / 細胞情報伝達 / シグナル伝達 / connexin43 / ischemic injury / 心不全 / RIP1 / mTORC1 / TFEB / heart failure / signal tranduction Less

Cross-talk of cardiomyocyte necroptosis and autophagy in heart failure
- Principal Investigator
  
  Tetsuji Miura
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta
- Principal Investigator
  
  Tanno Masaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University
Role of mitochondrial permeability transition in necroptosis of the cardiomyocyte
- Principal Investigator
  
  Miura Tetsuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University
Protein kinases regulating the mitochondrial permeability transition pore
- Principal Investigator
  
  TETSUJI Miura
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Role of connexin-43 in protective signaling incardiomyocyte
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Roles of connexin-43 in cardiomyocyte tolerance against ischemic injury
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Intracellular Signaling Mechanisms Regulating Functions and Expression of the Gap Junction in Ischemic Myocardium
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
PKC-ε活性化による心筋虚血再灌流障害の抑制の分子機構Principal Investigator
- Principal Investigator
  
  三木隆幸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Modification of gap junctions during myocardial ischemia and its significance in myocardial necrosis
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University

[Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload.2021
- Author(s)
  Igaki Yusuke、Tanno Masaya、Sato Tatsuya、Kouzu Hidemichi、Ogawa Toshifumi、Osanami Arata、Yano Toshiyuki、Kuno Atsushi、Miki Takayuki、Nakamura Takashi、Miura Tetsuji
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 154 Pages: 21-31
- DOI
  10.1016/j.yjmcc.2021.01.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08522, KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-21K08110
[Journal Article] mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.2020
- Author(s)
  Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T.
- Journal Title
  
  Biochim Biophys Acta Mol Basis Dis
  
  Volume: 1865 Pages: 165552-165552
- DOI
  10.1016/j.bbadis.2019.165552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-19K08544
[Journal Article] Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-12020
- Author(s)
  Ohwada W, Tanno M, Yano T, Ong SB, Abe K, Sato T, Kuno A, Miki T, Sugawara H, Igaki Y, Miura T.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1866 Pages: 165851-165851
- DOI
  10.1016/j.bbadis.2020.165851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-18K08079
[Journal Article] Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts2018
- Author(s)
  Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T.
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 119 Pages: 138-146
- DOI
  10.1016/j.yjmcc.2018.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09584, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-16K09505
[Journal Article] Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts2018
- Author(s)
  Mizuno M, Kuno A, Yano T, Miki T, Oshima H, Sato T, Nakata K, Kimura Y, Tanno M, Miura T
- Journal Title
  
  Physiological Reports
  
  Volume: 6
- DOI
  10.14814/phy2.13741
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-16K09505, KAKENHI-PROJECT-17K16016
[Journal Article] Does p53 Inhibition Suppress Myocardial Ischemia?Reperfusion Injury?2018
- Author(s)
  Yano T, Abe K, Tanno M, Miki T, Kuno A, Miura T, Steenbergen C
- Journal Title
  
  Journal of Cardiovascular Pharmacology and Therapeutics
  
  Volume: 印刷中 Pages: 350-357
- DOI
  10.1177/1074248418763612
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09505, KAKENHI-PROJECT-18K08079
[Journal Article] Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55α contributes to enlargement of infarct size by chronic kidney disease2017
- Author(s)
  Toshiyuki Tobisawa*, Toshiyuki Yano*, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Yukishige Kimura, Satoko Ishikawa, Hidemichi Kouzu, Keitaro Nishizawa, Hideaki Yoshida, Tetsuji Miura
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 112 Pages: 31-31
- DOI
  10.1007/s00395-017-0621-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461133, KAKENHI-PROJECT-16K09505
[Journal Article] Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size.2016
- Author(s)
  Nishizawa K, Yano T, Tanno M, Miki T, Kuno A, Tobisawa T, Ogasawara M, Muratsubaki S, Ohno K, Ishikawa S, Miura T.
- Journal Title
  
  Hypertension
  
  Volume: 68 Pages: 697-706
- DOI
  10.1161/hypertensionaha.116.07480
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461133, KAKENHI-PROJECT-16K09505
[Journal Article] Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy.2016
- Author(s)
  Yano T, Shimoshige S, Miki T, Tanno M, Mochizuki A, Fujito T, Yuda S, Muranaka A, Ogasawara M, Hashimoto A, Tsuchihashi K, Miura T
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 91 Pages: 6-9
- DOI
  10.1016/j.yjmcc.2015.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats.2015
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Ishikawa S, Tobisawa T, Ogasawara M, Nishizawa K, Miura T.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 14 Pages: 103-118
- DOI
  10.1186/s12933-015-0264-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.2015
- Author(s)
  Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, Toshiyuki Tobisawa, Makoto Ogasawara, Satoko Ishikawa, Tetsuji Miura
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 80 Pages: 136-145
- DOI
  10.1016/j.yjmcc.2015.01.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860611, KAKENHI-PROJECT-26461132, KAKENHI-PROJECT-26461133
[Journal Article] Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).2014
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, Murase H, Tobisawa T, Ogasawara M, Horio Y, Miura T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Pages: 29285-29296
- DOI
  10.1074/jbc.m114.563924
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461132, KAKENHI-PROJECT-26461133
[Journal Article] Type 2 diabetes induces subendocardium-predominant reduction in transient outward K^+ current with downregulation of Kv4.2 and KChIP22014
- Author(s)
  Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N.
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 306
- DOI
  10.1152/ajpheart.00414.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.2014
- Author(s)
  Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, Miki T, Miura T
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0112529
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Diabetic cardiomyopathy : pathophysiology and clinical features2013
- Author(s)
  Miki T, Yuda S, Kouzu H, Miura T.
- Journal Title
  
  Heart Fail Rev
  
  Volume: 18 Pages: 149-166
- DOI
  10.1007/s10741-012-9313-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.2012
- Author(s)
  Ishikawa S, Kuno A, Tanno M, Miki T, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Journal Title
  
  American Journal of Physiology Heart and Circulatory Physiology
  
  Volume: 302
- DOI
  10.1152/ajpheart.00940.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.2012
- Author(s)
  Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0039893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning2012
- Author(s)
  Miki T, Itoh T, Sunaga D, Miura T.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 11 Pages: 67-67
- DOI
  10.1186/1475-2840-11-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts.2012
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Miura T
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 53 Pages: 870-879
- DOI
  10.1016/j.yjmcc.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K and Miura T
- Journal Title
  
  Hypertension
  
  Volume: 57 Pages: 110-115
- DOI
  10.1161/hypertensionaha.110.158469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T.
- Journal Title
  
  Hypertension
  
  Volume: 57 Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T.
- Journal Title
  
  Hypertension 57
  
  Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO.2010
- Author(s)
  Sato T, Tanno M. Miki T, Yano T, Sato T, Shimamoto K, Miura T.
- Journal Title
  
  Cardiovasc Drugs Ther 24
  
  Pages: 401-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Role of the gap junction in ischemic preconditioning in the heart.2010
- Author(s)
  Miura T. Miki T. Yano T.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.2010
- Author(s)
  Hotta H, Miura T. Miki T, Togashi N, Maeda T. Kim SJ, Tanno M Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K.
- Journal Title
  
  Circ Res 106
  
  Pages: 129-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.2010
- Author(s)
  Terashima Y, Sato T, Yano T, Maas O, Itoh T, Miki T, Tanno M, Kuno A, Shimamoto K, Miura T.
- Journal Title
  
  J Mol Cell Cardiol 49
  
  Pages: 762-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3β-mediated suppression of mitochondrial permeability transition.2009
- Author(s)
  Miki T Miura T, Hotta H, Tanno M, Yano T, Sato T, Terashima Y, Takada A, Ishikawa S, Shimamoto K.
- Journal Title
  
  Diabetes 58
  
  Pages: 2863-2872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Drug development targeting the glycogen synthase kinase-3β (GSK-3β)-mediated signal transduction pathway : role of GSK-3β in myocardial protection against ischemia/reperfusion injury.2009
- Author(s)
  Miura T, Nishihara M, Miki T.
- Journal Title
  
  J Pharmacol Sci 109
  
  Pages: 162-167
- NAID
  10025734088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] GSK-3β, a therapeutic target for cardiornyocyte protection.2009
- Author(s)
  Miura T Miki T.
- Journal Title
  
  Circ J 73
  
  Pages: 1184-1192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning.2009
- Author(s)
  Naitoh K, Yano T, Miura T, Itoh T, Miki T Tanno M Sato T, Hotta H, Terashima Y, Shimamoto K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion.2008
- Author(s)
  Kobayashi H, Miura T. Ishida H, Miki T. Tanno M Yano T, Sato T, Hotta H, Shimamoto K.
- Journal Title
  
  Clin Exp Pharmacol Physiol 35
  
  Pages: 812-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Limitation of myocardial infarct size in the clinical setting : current status and challenges in translating animal experiments into clinical therapy.2008
- Author(s)
  Miura T, Miki T.
- Journal Title
  
  Basic Res Cardiol 103
  
  Pages: 501-513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis.2008
- Author(s)
  Ohori K, Miura T, Tanno M, Miki T, Sato T, Ishikawa S, Horio Y, Shimamoto K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Ischemic preconditioning activate AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.2004
- Author(s)
  Nishino Y, Miura T, Miki T, et al.
- Journal Title
  
  Cardiovasc Res 64
  
  Pages: 610-619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.2004
- Author(s)
  Nishino Y, Miura T, Miki T, et al.
- Journal Title
  
  Cardiovascular Research 61(3)
  
  Pages: 610-619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Presentation] Phosphorylated MLKL, an Executor of Necroptosis, Localized in the Nucleus and Intercalated Disc Plays Distinct Roles in Nonischemic Dilated Cardiomyopathy.2020
- Author(s)
  Fujita Y, Yano T, Nagano N, Nishikawa R, Kamiyama N, Fujito T, Mochizuki A, Koyama M, Kouzu H, Muranaka A, Nagahara D, Tannno M, Miki T, Miura T.
- Organizer
  第84回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy.2020
- Author(s)
  Ogawa T, Kouzu H, Tatekoshi Y, Osanami A, Oshima H, Mizuno M, Kuno A, Igaki Y, Sugawara H, Fujita Y, Sato T, Yano T, Tanno M, Miki T, Miura T.
- Organizer
  European Society of Cardiology Congress 2020
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Activation of necroptotic pasthway by downregulated caspase-8 expression is associated with progression of left ventricular remodeling in nonischemic dilated cardiomyopathy.2019
- Author(s)
  Fujita Y, Yano T, Abe K, Nagano N, Kamiyama N, Fujito T, Mochizuki A, Koyama M, Kouzu H, Muranaka A, Nagahara D, Tanno M, Miki T, Miura T
- Organizer
  ESC congress 2019. Paris, France.
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] mTORC1 suppresses cardiomyocyte necroptosis through autophagy and RIP1 inhibition2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Miura T.
- Organizer
  日本循環器学会基礎医学フォーラム
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Inhibition of mTORC1 supresses necroptosis of cardiomyocytes in a p70S6K-independent mechanism by suppression of p62-RIP1 interaction.2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Miura T.
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] mTORC1 inhibition suppresses necroptosis through restroration of autophagic flux by inhibitory phosphorylation of RIP1 in cardiomyocytes.2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Mizuno M, Miura T.
- Organizer
  European Society of Cardiology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Crosstalk between Aberrant mTORC1 Activation and Necroptotic Pathway: a Novel Therapeutic Target in Ischemic Heart Disease2018
- Author(s)
  Yano T, Abe K, Ogasawara M, Kuno A, Tanno M, Miki T, Miura T.
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Increased activity of AMP deaminase by decreased interaction with PGM1 and depletion of F1,6P: a novel mechanism of diabetic cardiomyopathy2016
- Author(s)
  Y. Tatekoshi, H. Kouzu, M. Tanno, A. Kuno, S. Ishikawa, T. Yano, T. Miki , M. Ogasawara, T. Tobisawa, K. Ono, S. Muratsubaki, K. Nishizawa, T. Miura
- Organizer
  22nd Congress of International Society for Heart Research
- Place of Presentation
  Buenos Aires, Argentina
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Sequestration of p62 by RIP1 promotes necroptosis through suppression of autophagic flux in cardiomyocytes; a novel cross-talk between autophagy and necroptosis2016
- Author(s)
  Yano T, Ogasawara M, Miki T, Tanno M, Kuno A, Ohno K, Nishizawa K, Owada W, Mizuno M, Suwawara H, Tatekoshi Y, Nakata K, Ishikawa S, Miura T
- Organizer
  European Society of Cardiology Congress 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Excessive ROS production in mitochondria switches off protective mitochondrial kinase signaling.2016
- Author(s)
  Tanno M, Ohwada W, Yano T, Miki T, Kuno A, Ishikawa S, Tatekoshi Y, Nishizawa K, Mizuno M, Miura T.
- Organizer
  4th Congress of Frontiers in Cardiovascular Biology
- Place of Presentation
  Florence, Italy
- Year and Date
  2016-07-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Excessive ROS production in mitochondria switches off protective mitochondrial kinase signaling2016
- Author(s)
  Owada W, Tanno M, Yano T, Miki T, Kuno A, Ishikawa S, Tatekoshi Y, Nishizawa K, Mizuno M, Miura T.
- Organizer
  4th Congress of Frontiers in CardioVascular Biology, European Society of Cardiology
- Place of Presentation
  Florence, bItaly
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] ROS-induced mitochondrial translocation of phosphatases cancelscell-protective signals activated by phosphorylation of mitochondrial protective kinases2016
- Author(s)
  Ohwada W, Tanno M, Yano T, Kuno A, Miki T, Ishikawa S, Tatekoshi Y, Abe K, Ohno K, Mizuno M, Nakata K, Miura T.
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, U.S.A.
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Depletion of fructose 1,6-diphosphate but not post-translational modification plays a major role in activation of AMP deaminase in diabetic hearts: a novel mechanism for diabetic cardiomyopathy.2016
- Author(s)
  Y. Tatekoshi, M. Tanno, A. Kuno, S. Ishikawa, T. Yano, T. Miki, M. Ogasawara, T. Tobisawa, K. Ohno, S. Muratsubaki, K. Nishizawa, T. Miura
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Intramolecular inhibition of Ser473 phosphorylation by up-regulated Thr308 phosphorylation in Akt cotributes to enlargement of infarct size by chronic renal failure.2015
- Author(s)
  T. Tobisawa, T. Yano, T. Miki, M. Tanno, A. Kuno, H. Kouzu, M. Ogasawara, S. Muratsubaki, K. Ohno, K. Nishizawa, M. Mizuno, W. Owada, S. Ishikawa, T. Miura.
- Organizer
  88th Scientific Session of American Heart Association:
- Place of Presentation
  Orlando, U.S.A.
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Continuous erythropoietin receptor activation reverses increased myocardial susceptibility to ischemia/reperfusion injury in chronic renal failure.2015
- Author(s)
  K. Nishizawa, T. Yano, T. Miki, M. Tanno, A. Kuno, H. Kouzu, T. Tobisawa, M. Mizuno, H. Sugawara, T. Miura.
- Organizer
  37th Congress of the European Society of Cardiology
- Place of Presentation
  London, UK
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Suppression of Autophagic Flux by Sequestration of p62 Promotes RIP1-mediated Necroptosis in Cardiomyocytes2015
- Author(s)
  Makoto Ogasawara; Toshiyuki Yano; Takayuki Miki; Masaya Tanno; Atsushi Kuno; Hidemichi Kouzu; Toshiyuki Tobisawa; Shingo Muratsubaki; Kohei Ohno; Keitaro Nishizawa; Satoko Ishikawa; Tetsuji Miura
- Organizer
  Scientific Sessions of the American Heart Association 2015
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Acceleration of mPTP re-closure after oxidant stress by mitochondrial K_<ATP> channel activation is achieved by suppression of residual ROS production2014
- Author(s)
  Ogasawara M, Kuno A, Ishikawa S, Tobisawa T, Kouzu H, Yano T, Miki T, Miura T
- Organizer
  The 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Acceleration of mPTP Re-closure after Oxidant Stress by Mitochondrial KATP Channel Activation is Achieved by Suppression of Residual ROS Production2014
- Author(s)
  Ogasawara M, Kuno A, Ishikawa S, Tobisawa T, Kouzu H, Yano T, Miki T, and Miura T.
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Type 2 diabetes induces ventricular electrical remodeling with a transmural gradient2013
- Author(s)
  Tobisawa T, Sato T, Yuda S, Miki T, Tanno M, Kuno A, Kobayashi T, Akasaka H, Tohse N, Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Interaction of cyclophilin D with inorganic phosphate carrier during ischemia determines threshold for mPTP opening and reperfusion-induced cell necrosis2013
- Author(s)
  Ito T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Ishikawa S, Miura T
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Mechanisms underlying mitochondrial translocation of GSK-3beta, a crucial induces of mitochondrial permeability transition : GSK-3beta activity, interaction with VDAC2 and a mitochondrial targeting sequence2013
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Ogasawara M, Tobisawa T, Murase H, Sato T, Kouzu H, Miki T, Miura T
- Organizer
  American Heart Association BCVS
- Place of Presentation
  Las Vegas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Mechanisms Underlying Mitochondrial Translocation Of GSK-3β, A Crucial Inducer Of Mitochondrial Permeability Transition: GSK-3β Activity, Interaction With VDAC2 And A Mitochondrial Targeting Sequence.2013
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Ogasawara M, Tobisawa T, Murase H, Sato T, Kouzu H, Miki T, and Miura T
- Organizer
  American Heart Association BCVS 2013
- Place of Presentation
  Las Vegas, Nevada, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Interaction with VDAC2 promotes mitochondrial translocation of GSK-3beta in a kinase activity-dependent manner and induces cell death.2013
- Author(s)
  Masaya Tanno,Takayuki Miki, Atsushi Kuno , Hidemichi Kouzu, Takahito Itoh , Tatsuya Satoh, Satoko Ishikawa, Daisuke Sunaga, Tetsuji Miura
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the glucagon-like peptide-1 receptor restores myocardial autophagic flux and reduced mortality after myocardial infarction in diabetic rats2013
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T
- Organizer
  Scientific Sessions 2013, the American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the Glucagon-Like Peptide-1 Receptor Restores Myocardial Autophagic Flux and Reduces Mortality After Myocardial Infarction in Diabetic Rats2013
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Tobisawa T, Ogasawara M, Ishikawa S, and Miura T.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Interaction of cyclophilin D with inorganic phosphate carrier during ischemia determines threshold for mPTP opening and reperfusion-induced cell necrosis.2013
- Author(s)
  Takahito Ito,Hidemichi Kouzu , Takayuki Miki , Masaya Tanno , Atsushi Kuno , Tatsuya Satoh , Daisuke Sunaga , Hiromichi Murase , Satoko Ishikawa , Tetsuji Miura
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Interaction with VDAC2 promotes mitochondrial traslocation of GSK-3beta in a kinase activity-dependent manner and induces cell death2013
- Author(s)
  Tanno M, Miki T, Kuno A, Kouzu H, Itoh T, Sato T, Ishikawa S, Sunaga D, Miura
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the mitochondrial ATP-sensitive potassium channel achieves cell protection by promoting re-closure of the mPTP via suppression of GSK-3beta - complex III interaction2013
- Author(s)
  Sunaga D, Tanno M, Miki T, Kuno A, Kouzu H, Sato T, Ishikawa S, Ogasawara M, Tobisawa T, and Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Facilitated re-closure of the mitochondrial permeability transition pore underlies protection of cardiomyocytes from ROS-induced necrosis by activation of the mitochondrial ATP-sensitive K^+ channel2012
- Author(s)
  Suanga D, Kuno A, Ishikawa S, Miki T, Tanno M, Kouzu H, Itoh T, Sato T, Murase H, Miura T
- Organizer
  Scientific Sessions 2012, the American Heart Association
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Titin-isoform shift may underlie distinct ventricular responses to pressure and volume overloads in type 2 diabetic heart2012
- Author(s)
  Kouzu H, Kuno A, Miki T, Tanno M, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Organizer
  Scientific Sessions 2012, the American Heart Association
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Facilitated Re-Closure of the Mitochondrial Permeability Transition Pore Underlies Protection of Cardiomyocytes from ROS-Induced Necrosis by Activation of the Mitochondrial ATP-Sensitive K+ Channel2012
- Author(s)
  Daisuke Sunaga, Atsushi Kuno, Satoko Ishikawa, Takayuki Miki, Masaya Tannno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Hiromichi Murase, and Tetsuji Miura
- Organizer
  Scientific Sessions 2012, the American Heart Assocaition
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Titin-isoform Shift May Underlie Distinct Ventricular Responses to Pressure and Volume Overloads in Type 2 Diabetic Heart2012
- Author(s)
  Hidemichi Kouzu, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, and Tetsuji Miura
- Organizer
  Scientific Sessions 2012, the American Heart Assocaition
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] UPR In Endoplasmic Reticulum vs. UPR In Mitochondria In Diabetic Myocardium: Which Is Responsible For Deficient Regulation Of Mitochondrial Permeability Transition Pores?2011
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno T, Kuno A, Sato T, Sunaga D, Ishikawa S, Miura T
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] UPR in endoplasmic reticulum vs. in mitochondria in diabetic myocardium : which is responsible for deficient regulation of mitochondrial permeability transition pores?2011
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Ishikawa S, Miura
- Organizer
  Scientific Sessions 2011, the American Heart Association
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Increased ER stress is a fundamental mechanism for impairment of cardioprotective signaling in type 2 diabetes.2010
- Author(s)
  Kouzu H, Itoh T, Miki T. Tanno M, Yano Y, Sato T, Takada A, Sunaga D, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Ventricular dysfunction and blunted response to adrenergic stimulation in obese type 2 diabetes predispose to fatal heart failure after infarction : Possible involvement of microRNA-1 down-regulation.2010
- Author(s)
  Takada A, Miki T Tanno M, Suzuki H, Yano T, Kuno A, Itoh T, Sato T, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Mitochondria is a critical compartment for phospho-GSK-3β to afford cytoprotection against ischemia/reperfusion injury.2010
- Author(s)
  Sato T, Miura T, Tanno M, Miki T, Takada A, Itch T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin43-dependent mitochondrial GSK-3β phosphorylation in protection of cardiomyocyte against necrosis.2010
- Author(s)
  Ishikawa S, Miki T, Tanno M, Miura T.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Glycogen synthase kinase-3β as a therapeutic target for cardiomyocyte protection.2010
- Author(s)
  Miura T. Miki T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin-43 contributes to transmission of MitoK_ATP channel-derived redox signal to Akt-GSK-3β pathway in cardiomyocyte protection afforded by G protein-coupled receptors.2010
- Author(s)
  Ishikawa S, Kuno A, Miki T, Tanno T. Yano T, Kouzu H, Sato T, Sunaga D, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Role of GSK-3β in negative regulation of the mPTPs by the mitochondrial K_ATP channel.2010
- Author(s)
  Itch T, Terashima Y, Miki T, Miura T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Jak2-mediated cardioprotective signaling is impaired in diabetic hearts by AT_1 receptormediated up-regulation of calcineurin.2009
- Author(s)
  Miura T, Hotta H, Miki T, Yano T, Ishikawa S, Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Enhanced ANT-cyclophilin-D interaction underlies reduced anti-infarct tolerance and loss of protective response to erythropoietin in hypertensive hypertrophied hearts.2009
- Author(s)
  Miki T. Yano T, Miura T, Tanno M. Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Role of GSK-3β in negative regulation of mitochondrial permeability transition pore by the mitochondrial K_ATP channel.2009
- Author(s)
  Miura T, Terashima Y, Maas O, Miki T, Tanno M, Ishikawa S, Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] ER stress contributes to dysregulation of GSK-3β-medaited suppression of mitochondrial permeability transition in diabetic hearts.2008
- Author(s)
  Takayuki Miki, et al.
- Organizer
  81^<st> Scientific Sessions of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] ER stress contributes to dysregulation of GSK-3β-mediated suppression of mitochondrial permeability transition in diabetic hearts.2008
- Author(s)
  Miki T, Tanno M, Kuno A, Yano T, Sato T, Hotta H, Ichikawa S, Miura T.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin43-dependent and-independent mechanisms of mitochondrial GSK-3β phosphorylation in protection of cardiomyocyte against necrosis.2008
- Author(s)
  Ishikawa S, Miura T, Tanno M, Kuno A, Sato T, Hotta H, Terashima Y, Miki T.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] ES stress contributes to dysregulation of GSK-3β-medaited suppression of mitochondrial permeability transition in diabetic hearts.2008
- Author(s)
  Takayuki Miki, et al.
- Organizer
  81^<st> Scientific Sessions of American Heart Association
- Place of Presentation
  New Orleans, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Activation of a protein deacetylase, SIRTI, by Resveratol suppresses progression of heart failure and improves survival by up-regulation of Mn-SOD.2008
- Author(s)
  Tanno M Kuno A, Miki T. Miura T. Horio Y, Shimamoto K.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Modulation of Akt/GSK-3β signaling and mitochondrial GSK-3βby ER stress underlies failure of erythropoietin to protect diabetic hearts.2007
- Author(s)
  Takayuki Miki, et al.
- Organizer
  80^<th> Scientific Sessions of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Modification of Akt/GSK-3b signaling and mitochondrial GSK-3β by ER stress underlies failure of erythropoietin to protect diabetic hearts.2007
- Author(s)
  Takayuki Miki
- Organizer
  American Heart Association Scientific Sessions 2007
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Modulation of Akt/GSK-3β signaling and mitochondrial GSK-3β by ER stress underlies failure of erythropoietin to protect diabetic hea2007
- Author(s)
  Takayuki Miki, et al.
- Organizer
  80^<th> Scientific Sessions of American Heart Association
- Place of Presentation
  Orlando, USA.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Mitochondrial translocation of GSK-3β, a trigger of mitochondrial permeability transition, is mediated by its N-terminal domain and promoted by interaction with VDAC2.
- Author(s)
  Tanno M, Ishikawa S, Miki T, Kuno A, Kouzu H, Yano T, Miura T
- Organizer
  Frontiers in Cardiovascular Biology, 3rd meeting of the ESC council on basic cardiovascular science
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Accumulation of p62 by dysregulation of autophagy induces RIP1-dependent necroptosis in cardiomyocytes: a novel interplay between autophagy and necroptosis.
- Author(s)
  Ogasawara M, Yano T, Miki T, Tanno M, Kuno A, Kouzu H, Murase H, Tobisawa T, Muratsubaki S, Nishizawa K, Mizuno M, Ishikawa S, Miura T.
- Organizer
  American Heart Association, Scientific Sessions 2014
- Place of Presentation
  Chicago, Illinois, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461133

1. MIURA Tetsuji (90199951)

# of Collaborated Projects: 8 results

# of Collaborated Products: 84 results
2. TANNO Masaya (00398322)

# of Collaborated Projects: 5 results

# of Collaborated Products: 69 results
3. UNO Kikuya (50305223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAKAMOTO Jun (40336392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 矢野俊之 (40444913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
6. KUNO Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 佐藤達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 神津英至

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MIKI Takayuki 三木 隆幸

三木 隆幸 ミキ タカユキ

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PKC-ε活性化による心筋虚血再灌流障害の抑制の分子機構Principal Investigator

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[Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload.2021

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[Journal Article] mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.2020

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[Journal Article] Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-12020

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[Journal Article] Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts2018

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[Journal Article] Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts2018

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[Journal Article] Does p53 Inhibition Suppress Myocardial Ischemia?Reperfusion Injury?2018

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MIKI Takayuki 三木隆幸

三木隆幸ミキタカユキ