Miura Tetsuji 三浦哲嗣

… Alternative Names

MIURA Tetsuji 三浦哲嗣

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Researcher Number	90199951
Other IDs	https://orcid.org/0000-0002-3977-2679
Affiliation (Current)	2023: 北海道科学大学, 薬学部, 教授 2023: 札幌医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2021: 札幌医科大学, 医学部, 名誉教授 2010 – 2020: Sapporo Medical University, 医学部, 教授 2007 – 2009: Sapporo Medical University, 2^<nd> Dept. of Internal Medicine, Associate Professor 2004 – 2006: 札幌医科大学, 医学部, 助教授 2001 – 2002: 札幌医科大学, 医学部, 助教授 1996 – 1998: 札幌医科大学, 医学部, 助教授 1992 – 1993: 札幌医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Epidemiology and preventive medicine
Keywords	Principal Investigator 細胞内情報伝達 / 細胞死 / signal transduction / mitochondria / preconditioning / myocardial infarction / protein kinase C / gap junction / コネキシン / ミトコンドリア … More / cell death / ネクロプトーシス / adenosine / ischemia / 心筋虚血 / connexin / protein kinase / 心筋細胞 / necroptosis / autophagy / オートファジー / potassium channel / アデノシン / myocardial ischemia / ギャップ結合 / 心不全 / 細胞シグナル / connexin-43 / G protein coupled receptor / β-subunit / 細胞内情報電達 / 活性酸素 / 透過性遷移孔 / myocardium / Preconditioning / ストレス蛋白質 / Kチャネル / 心筋梗塞 / 虚血 / 心筋スタニング / stress proteins / K channels / Cキナーゼ / MAP kinase / ATP-sensitive K+ channel / ATP-sensitive potassium channel / コネキシン43 / 蛋白キナーゼ / 虚血障害 / プレコンディショニング / 細胞情報伝達 / シグナル伝達 / connexin43 / ischemic injury / RIP1 / mTORC1 / TFEB / heart failure / signal tranduction / 細胞骨格 … More Except Principal Investigator 心不全 / 細胞死 / 酸化ストレス / 分子心臓病態学 / エピジェネティクス / ヒストン脱アセチル化酵素 / 細胞内局在 / SIRT1 / 糖尿病 / 特定健診・特定保健指導 / 生活習慣病罹患ハイリスク者 / 決定木分析 / CART / 地域一般住民コホート / 生活習慣病 / 高血圧 / ミトコンドリア透過性遷移孔 / グリコーゲン合成酵素キナーゼ3beta / グリコーゲン合成酵素キナーゼ3β / GSK-3β / 糖尿病性心筋症 / AMPデアミナーゼ / 拡張機能障害 / Sarcoplasmic Reticulum Less

Intracellular signal transduction regulating necroptosis of cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  三浦哲嗣
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Cross-talk of cardiomyocyte necroptosis and autophagy in heart failurePrincipal Investigator
- Principal Investigator
  
  Tetsuji Miura
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Sapporo Medical University
Development of novel therapeutic approach for diabetic cardiomyopathy by modification of AMP deaminase activity.
- Principal Investigator
  
  Tanno Masaya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University
Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta
- Principal Investigator
  
  Tanno Masaya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University
Role of mitochondrial permeability transition in necroptosis of the cardiomyocytePrincipal Investigator
- Principal Investigator
  
  Miura Tetsuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Sapporo Medical University
Establishment of classification and regression tree model for assessing of a risk for future occurence of life-style related disease using a community-based cohort data.
- Principal Investigator
  
  Ohnishi Hirofumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Sapporo Medical University
Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase
- Principal Investigator
  
  TANNO Masaya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Protein kinases regulating the mitochondrial permeability transition porePrincipal Investigator
- Principal Investigator
  
  TETSUJI Miura
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure
- Principal Investigator
  
  TANNO Masaya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Role of connexin-43 in protective signaling incardiomyocytePrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Roles of connexin-43 in cardiomyocyte tolerance against ischemic injuryPrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Intracellular Signaling Mechanisms Regulating Functions and Expression of the Gap Junction in Ischemic MyocardiumPrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Modification of gap junctions during myocardial ischemia and its significance in myocardial necrosisPrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Suppression of ischemic myocardial injury by heat stress proteinsPrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Mechanism of preconditioning against myocardial infarctionPrincipal Investigator
- Principal Investigator
  
  MIURA Tetsuji
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University

[Book] 今日の疾患辞典2019
- Author(s)
  丹野雅也、三浦哲嗣
- Publisher
  株式会社プレシジョン
- Data Source
  KAKENHI-PROJECT-17K09584
[Journal Article] Role of Erythropoiesis-Stimulating Agents in Cardiovascular Protection in CKD Patients: Reappraisal of Their Impact and Mechanisms.2022
- Author(s)
  Miura Tetsuji、Sato Tatsuya、Yano Toshiyuki、Takaguri Akira、Miki Takayuki、Tohse Noritsugu、Nishizawa Keitaro
- Journal Title
  
  Cardiovasc Drugs Ther.
  
  Volume: Online ahead of print. Pages: 00-00
- DOI
  10.1007/s10557-022-07321-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08522, KAKENHI-PROJECT-21K08035
[Journal Article] Diabetes modulation of the myocardial infarction-acute kidney injury axis.2022
- Author(s)
  Miura Tetsuji、Kuno Atsushi、Tanaka Marenao
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 322
- DOI
  10.1152/ajpheart.00639.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08708, KAKENHI-PROJECT-21K08035
[Journal Article] Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury2021
- Author(s)
  Sugawara Hirohito、Moniwa Norihito、Kuno Atsushi、Ohwada Wataru、Osanami Arata、Shibata Satoru、Kimura Yukishige、Abe Koki、Gocho Yufu、Tanno Masaya、Miura Tetsuji
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 145 Pages: 187-197
- DOI
  10.1016/j.jphs.2020.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-18K08079
[Journal Article] Xanthine oxidoreductase-mediated injury is amplified by upregulated AMP deaminase in type 2 diabetic rat hearts under the condition of pressure overload.2021
- Author(s)
  Igaki Yusuke、Tanno Masaya、Sato Tatsuya、Kouzu Hidemichi、Ogawa Toshifumi、Osanami Arata、Yano Toshiyuki、Kuno Atsushi、Miki Takayuki、Nakamura Takashi、Miura Tetsuji
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 154 Pages: 21-31
- DOI
  10.1016/j.yjmcc.2021.01.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08522, KAKENHI-PROJECT-20K08452, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-21K08110
[Journal Article] Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model.2021
- Author(s)
  Shibata Satoru、Moniwa Norihito、Kuno Atsushi、Kimura Ayumu、Ohwada Wataru、Sugawara Hirohito、Gocho Yufu、Tanaka Marenao、Yano Toshiyuki、Furuhashi Masato、Tanno Masaya、Miki Takayuki、Miura Tetsuji
- Journal Title
  
  Clin Exp Nephrol.
  
  Volume: Online ahead of print Pages: 708-717
- DOI
  10.1007/s10157-021-02048-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-20K08913, KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-19K08708, KAKENHI-PROJECT-21K08035
[Journal Article] mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.2020
- Author(s)
  Abe K, Yano T, Tanno M, Miki T, Kuno A, Sato T, Kouzu H, Nakata K, Ohwada W, Kimura Y, Sugawara H, Shibata S, Igaki Y, Ino S, Miura T.
- Journal Title
  
  Biochim Biophys Acta Mol Basis Dis
  
  Volume: 1865 Pages: 165552-165552
- DOI
  10.1016/j.bbadis.2019.165552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-19K08544
[Journal Article] Distinct intra-mitochondrial localizations of pro-survival kinases and regulation of their functions by DUSP5 and PHLPP-12020
- Author(s)
  Ohwada W, Tanno M, Yano T, Ong SB, Abe K, Sato T, Kuno A, Miki T, Sugawara H, Igaki Y, Miura T.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1866 Pages: 165851-165851
- DOI
  10.1016/j.bbadis.2020.165851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08544, KAKENHI-PROJECT-18K08079
[Journal Article] Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts2018
- Author(s)
  Tatekoshi Y, Tanno M, Kouzu H, Abe K, Miki T, Kuno A, Yano T, Ishikawa S, Ohwada W, Sato T, Niinuma T, Suzuki H, Miura T.
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 119 Pages: 138-146
- DOI
  10.1016/j.yjmcc.2018.05.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09584, KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-16K09505
[Journal Article] Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts2018
- Author(s)
  Mizuno M, Kuno A, Yano T, Miki T, Oshima H, Sato T, Nakata K, Kimura Y, Tanno M, Miura T
- Journal Title
  
  Physiological Reports
  
  Volume: 6
- DOI
  10.14814/phy2.13741
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08079, KAKENHI-PROJECT-16K09505, KAKENHI-PROJECT-17K16016
[Journal Article] Does p53 Inhibition Suppress Myocardial Ischemia?Reperfusion Injury?2018
- Author(s)
  Yano T, Abe K, Tanno M, Miki T, Kuno A, Miura T, Steenbergen C
- Journal Title
  
  Journal of Cardiovascular Pharmacology and Therapeutics
  
  Volume: 印刷中 Pages: 350-357
- DOI
  10.1177/1074248418763612
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09505, KAKENHI-PROJECT-18K08079
[Journal Article] Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55α contributes to enlargement of infarct size by chronic kidney disease2017
- Author(s)
  Toshiyuki Tobisawa*, Toshiyuki Yano*, Masaya Tanno, Takayuki Miki, Atsushi Kuno, Yukishige Kimura, Satoko Ishikawa, Hidemichi Kouzu, Keitaro Nishizawa, Hideaki Yoshida, Tetsuji Miura
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 112 Pages: 31-31
- DOI
  10.1007/s00395-017-0621-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461133, KAKENHI-PROJECT-16K09505
[Journal Article] From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research".2016
- Author(s)
  Cabrera-Fuentes HA, Aragones J, Bernhagen J, Miura T, et al.
- Journal Title
  
  Basic Research in Cardiology
  
  Volume: 111 Pages: 69-69
- DOI
  10.1007/s00395-016-0586-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Chronic Treatment With an Erythropoietin Receptor Ligand Prevents Chronic Kidney Disease-Induced Enlargement of Myocardial Infarct Size.2016
- Author(s)
  Nishizawa K, Yano T, Tanno M, Miki T, Kuno A, Tobisawa T, Ogasawara M, Muratsubaki S, Ohno K, Ishikawa S, Miura T.
- Journal Title
  
  Hypertension
  
  Volume: 68 Pages: 697-706
- DOI
  10.1161/hypertensionaha.116.07480
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461133, KAKENHI-PROJECT-16K09505
[Journal Article] Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.2016
- Author(s)
  Hausenloy DJ, Barrabes JA, Davidson SM, Di Lisa F, Downey J, Miura T, et al.
- Journal Title
  
  Basic Research in Cardiology
  
  Volume: 111 Pages: 70-70
- DOI
  10.1007/s00395-016-0588-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Clinical impact of myocardial mTORC1 activation in nonischemic dilated cardiomyopathy.2016
- Author(s)
  Yano T, Shimoshige S, Miki T, Tanno M, Mochizuki A, Fujito T, Yuda S, Muranaka A, Ogasawara M, Hashimoto A, Tsuchihashi K, Miura T
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 91 Pages: 6-9
- DOI
  10.1016/j.yjmcc.2015.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats.2015
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Ishikawa S, Tobisawa T, Ogasawara M, Nishizawa K, Miura T.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 14 Pages: 103-118
- DOI
  10.1186/s12933-015-0264-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.2015
- Author(s)
  Hidemichi Kouzu, Takayuki Miki, Masaya Tanno, Atsushi Kuno, Toshiyuki Yano, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, Toshiyuki Tobisawa, Makoto Ogasawara, Satoko Ishikawa, Tetsuji Miura
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 80 Pages: 136-145
- DOI
  10.1016/j.yjmcc.2015.01.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860611, KAKENHI-PROJECT-26461132, KAKENHI-PROJECT-26461133
[Journal Article] Translocation of glycogen synthase kinase-3β (GSK-3β), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2).2014
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Miki T, Kouzu H, Yano T, Murase H, Tobisawa T, Ogasawara M, Horio Y, Miura T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Pages: 29285-29296
- DOI
  10.1074/jbc.m114.563924
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461132, KAKENHI-PROJECT-26461133
[Journal Article] Type 2 diabetes induces subendocardium-predominant reduction in transient outward K^+ current with downregulation of Kv4.2 and KChIP22014
- Author(s)
  Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N.
- Journal Title
  
  Am J Physiol Heart Circ Physiol
  
  Volume: 306
- DOI
  10.1152/ajpheart.00414.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling2014
- Author(s)
  Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, Steenbergen C.
- Journal Title
  
  Circ Res
  
  Volume: 114 Pages: 1268-1280
- DOI
  10.1161/circresaha.114.303562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086, KAKENHI-PROJECT-26461133
[Journal Article] HASF, a PKC-εactivator with novel features for cardiomyocyte protection2014
- Author(s)
  Miura T
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 69 Pages: 1-3
- DOI
  10.1016/j.yjmcc.2014.01.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Accelerated recovery of mitochondrial membrane potential by GSK-3β inactivation affords cardiomyocytes protection from oxidant-induced necrosis.2014
- Author(s)
  Sunaga D, Tanno M, Kuno A, Ishikawa S, Ogasawara M, Yano T, Miki T, Miura T
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0112529
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461133
[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein2013
- Author(s)
  Kuno A et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Pages: 5963-5972
- DOI
  10.1074/jbc.m112.392050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Diabetic cardiomyopathy : pathophysiology and clinical features2013
- Author(s)
  Miki T, Yuda S, Kouzu H, Miura T.
- Journal Title
  
  Heart Fail Rev
  
  Volume: 18 Pages: 149-166
- DOI
  10.1007/s10741-012-9313-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up: a case report.2012
- Author(s)
  Sato T, Miki T, Murakami N, Hirohashi Y, Kouzu H, Furuhashi M, Tanno M, Yuda T, Saitoh S, Hasegawa T, Miura T
- Journal Title
  
  Pathol Int
  
  Volume: 62 Pages: 827-29
- DOI
  10.1111/pin.12017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591106
[Journal Article] 高齢者の心不全の病態、臨床的特徴と診断・治療上の注意点2012
- Author(s)
  丹野雅也、三浦哲嗣
- Journal Title
  
  月刊循環器 Circulation
  
  Volume: 2 Pages: 38-50
- Data Source
  KAKENHI-PROJECT-23591085
[Journal Article] Emerging beneficial roles of sirtuins in heart failure2012
- Author(s)
  Tanno M et al.
- Journal Title
  
  Basic Research in Cardiology
  
  Volume: 107 Pages: 273-273
- DOI
  10.1007/s00395-012-0273-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.2012
- Author(s)
  Ishikawa S, Kuno A, Tanno M, Miki T, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Journal Title
  
  American Journal of Physiology Heart and Circulatory Physiology
  
  Volume: 302
- DOI
  10.1152/ajpheart.00940.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] The mPTP and its regulatory proteins: final common targets of signalling pathways for protection against necrosis2012
- Author(s)
  Miura T, Tanno M
- Journal Title
  
  Cardiovascular Research
  
  Volume: 94 Pages: 181-189
- DOI
  10.1093/cvr/cvr302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Trials, tribulations and speculation! Report from the 7th Biennial Hatter Cardiovascular Institute Workshop2012
- Author(s)
  Bell R, Beeuwkes R, Bøtker HE, Davidson S, Downey J, Garcia-Dorado D, Hausenloy DJ, Heusch G, Ibanez B, Kitakaze M, Lecour S, Mentzer R, Miura T, Opie L, Ovize M, Ruiz-Meana M, Schulz R, Shannon R, Walker M, Vinten-Johansen J, Yellon D
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 107 Pages: 300-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.2012
- Author(s)
  Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0039893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning2012
- Author(s)
  Miki T, Itoh T, Sunaga D, Miura T.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 11 Pages: 67-67
- DOI
  10.1186/1475-2840-11-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts.2012
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Miura T
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 53 Pages: 870-879
- DOI
  10.1016/j.yjmcc.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Resveratrol ameliorates muscular pathology in the dystriphic mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori SY, et al
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 338 Pages: 784-794
- DOI
  10.1124/jpet.111.183210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K and Miura T
- Journal Title
  
  Hypertension
  
  Volume: 57 Pages: 110-115
- DOI
  10.1161/hypertensionaha.110.158469
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T.
- Journal Title
  
  Hypertension
  
  Volume: 57 Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591086
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.2011
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K, Miura T.
- Journal Title
  
  Hypertension 57
  
  Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Mitochondrial kinase signalling pathways in myocardial protection fromischaemia/reperfusion-induced necrosis2010
- Author(s)
  Miura T, Tanno M, Sato T.
- Journal Title
  
  Cardiovasc Res 88
  
  Pages: 7-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Erythropoietin (EPO) affords more potent cardioprotection by activation of distinct signaling to mitochondrial kinases compared with carbamylated EPO.2010
- Author(s)
  Sato T, Tanno M. Miki T, Yano T, Sato T, Shimamoto K, Miura T.
- Journal Title
  
  Cardiovasc Drugs Ther 24
  
  Pages: 401-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Role of the gap junction in ischemic preconditioning in the heart.2010
- Author(s)
  Miura T. Miki T. Yano T.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Mitochondria and GSK-3beta in cardioprotection against ischemia/reperfusion injury.2010
- Author(s)
  Miura T, Tanno M.
- Journal Title
  
  Cardiovasc Drugs Ther 24
  
  Pages: 255-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts.2010
- Author(s)
  Hotta H, Miura T. Miki T, Togashi N, Maeda T. Kim SJ, Tanno M Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K.
- Journal Title
  
  Circ Res 106
  
  Pages: 129-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Epicardium and pericardium : a joint force for infarct repair?2010
- Author(s)
  Miura T.
- Journal Title
  
  J Mot Cell Cardiol 48
  
  Pages: 579-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure2010
- Author(s)
  Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 8375-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Hypertensive hypertrophied myocardium is vulnerable to infarction and refractory to erythropoietin-induced protection.2010
- Author(s)
  Yano T, Miki T, Tanno M, Kuno A, Itoh T, Takada A, Sato T, Kouzu H, Shimamoto K Miura T.
- Journal Title
  
  Hypertension 57
  
  Pages: 110-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Role of the gap junction in ischemic preconditioning in the heart2010
- Author(s)
  Tetsuji Miura, et al.
- Journal Title
  
  American Journal of Physiology -Heart and Circulatory Physiology 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Cytoskeletal proteins : hidden targets of cytoprotective signaling?2010
- Author(s)
  Miura T.
- Journal Title
  
  Circ J 74
  
  Pages: 2295-2296
- NAID
  10026972538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Role of the gap junction in ischemic preconditioning in the heart2010
- Author(s)
  Tetsuji Miura, et al.
- Journal Title
  
  American Journal of Physiology
  
  Volume: 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.2010
- Author(s)
  Terashima Y, Sato T, Yano T, Maas O, Itoh T, Miki T, Tanno M, Kuno A, Shimamoto K, Miura T.
- Journal Title
  
  J Mol Cell Cardiol 49
  
  Pages: 762-770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3β-mediated suppression of mitochondrial permeability transition.2009
- Author(s)
  Miki T Miura T, Hotta H, Tanno M, Yano T, Sato T, Terashima Y, Takada A, Ishikawa S, Shimamoto K.
- Journal Title
  
  Diabetes 58
  
  Pages: 2863-2872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase 3beta-mediated suppression of mitochondrial permeability transition2009
- Author(s)
  Miki T, Miura T, Hotta H, Tanno M, Yano T, Sato T, Ishikawa S, Shimamoto K.
- Journal Title
  
  Diabetes 58
  
  Pages: 2863-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Drug development targeting the glycogen synthase kinase-3β (GSK-3β)-mediated signal transduction pathway : role of GSK-3β in myocardial protection against ischemia/reperfusion injury.2009
- Author(s)
  Miura T, Nishihara M, Miki T.
- Journal Title
  
  J Pharmacol Sci 109
  
  Pages: 162-167
- NAID
  10025734088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] GSK-3β, a therapeutic target for cardiornyocyte protection.2009
- Author(s)
  Miura T Miki T.
- Journal Title
  
  Circ J 73
  
  Pages: 1184-1192
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning.2009
- Author(s)
  Naitoh K, Yano T, Miura T, Itoh T, Miki T Tanno M Sato T, Hotta H, Terashima Y, Shimamoto K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion.2008
- Author(s)
  Kobayashi H, Miura T. Ishida H, Miki T. Tanno M Yano T, Sato T, Hotta H, Shimamoto K.
- Journal Title
  
  Clin Exp Pharmacol Physiol 35
  
  Pages: 812-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Limitation of myocardial infarct size in the clinical setting : current status and challenges in translating animal experiments into clinical therapy.2008
- Author(s)
  Miura T, Miki T.
- Journal Title
  
  Basic Res Cardiol 103
  
  Pages: 501-513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Adenine nucleotide translocator, a mitochondrial carrier protein, and fate of cardiomyocytes after ischaemia/reperfusion.2008
- Author(s)
  Tanno M, Miura T.
- Journal Title
  
  Cardiovasc Res 80
  
  Pages: 1-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis.2008
- Author(s)
  Ohori K, Miura T, Tanno M, Miki T, Sato T, Ishikawa S, Horio Y, Shimamoto K.
- Journal Title
  
  Am J Physiol Heart Circ Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.2008
- Author(s)
  Nishino Y, Webb IG, Davidson SM, Ahmed AI, Clark JE, Jacquet S, Shah AM, Miura T, Yellon DM, Avkiran M, Marber MS.
- Journal Title
  
  Circ Res 103
  
  Pages: 307-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590870
[Journal Article] δ-Opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKOe-mediated phos phorylation of connexin432007
- Author(s)
  Tetsuji Miura, et al.
- Journal Title
  
  American Journal of Physiology 293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Journal Article] Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 432007
- Author(s)
  Tetsuji Miura
- Journal Title
  
  American Journal of Physiology 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590781
[Journal Article] δ-Opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-ε-mediated phosphorvlation of connexin 43.2007
- Author(s)
  Tetsuji Miura, et al.
- Journal Title
  
  American Journal of Physiology 293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590781
[Journal Article] Ischemic preconditioning, an endogenous protective mechanism in the cardiomyocyte, and its clinical application2006
- Author(s)
  Tetsuji Miura, et al.
- Journal Title
  
  Sapporo Medical Journal 75・4-6
  
  Pages: 19-28
- NAID
  120001795140
- Data Source
  KAKENHI-PROJECT-18590781
[Journal Article] Macrophage colony-stimulating factor treatment after myocardial infarction attenuates left ventricular dysfunction by accelerating infarct repair.2006
- Author(s)
  Yano T, Miura T, Whittaker P, et al.
- Journal Title
  
  Journal of American College of Cardiology 47(3)
  
  Pages: 626-634
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] MitoK_<ATP> channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism2006
- Author(s)
  Naitoh K, Ichikawa Y, Miura T, et al.
- Journal Title
  
  Cardiovascular Research 70(2)
  
  Pages: 374-383
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] MitoK_<ATP> channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.2006
- Author(s)
  Naitoh K, Ichikawa Y, Miura T, et al.
- Journal Title
  
  Cardiovascular Research 70(in press)
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] MitoK_<ATP> channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.2006
- Author(s)
  Naitoh K, Ichikawa Y, Miura T, et al.
- Journal Title
  
  Cardiovasc Res 70
  
  Pages: 374-383
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Macrophage colony-stimulating factor treatment after myocardial infarction attenuates left ventricular dysfunction by accelerating infarct repair.2006
- Author(s)
  Yano T, Miura T, Whittaker P, et al.
- Journal Title
  
  J Am Coll Cardiolo 47
  
  Pages: 624-634
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Intracardiac fibroblasts, but not bone marrow derived cells, are the origin of myfibroblasts in myocardial infarct repair.2005
- Author(s)
  Yano T, Miura T, Ikeda Y, et al.
- Journal Title
  
  Cardiovasc Pathol 14
  
  Pages: 241-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Intracardiac fibroblasts,but not bone marrow derived cells,are the origin of myofibroblasts in myocardial infarct repair.2005
- Author(s)
  Yano T, Miura T, Ikeda Y, et al.
- Journal Title
  
  Cardiovascular Pathology 14(5)
  
  Pages: 241-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Ischemic preconditioning activate AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.2004
- Author(s)
  Nishino Y, Miura T, Miki T, et al.
- Journal Title
  
  Cardiovasc Res 64
  
  Pages: 610-619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Role of microtubules in ischemic preconditioning against myocardial infarction.2004
- Author(s)
  Nakamura Y, Miura T, Nakano A, et al.
- Journal Title
  
  Cardiovascular Research 64(2)
  
  Pages: 322-330
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Role of microtubules in ischemic preconditioning against myocardial infarction.2004
- Author(s)
  Nakamura Y, Miura T, Nakano A, et al.
- Journal Title
  
  Cardiovasc Res 64
  
  Pages: 322-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] The role of ADAM protease in the tyrosine kinase-mediated trigger mechanism of ischemic preconditioning.2004
- Author(s)
  Ichikawa Y, Miura T, Nakano A, et al.
- Journal Title
  
  Cardiovasc Res 62
  
  Pages: 167-175
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] The role of ADAM protease in the tyrosine kinase-mediated trigger mechanism of ischemic preconditioning.2004
- Author(s)
  Ichikawa Y, Miura T, Nakano A, et al.
- Journal Title
  
  Cardiovascular Research 62(1)
  
  Pages: 167-175
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Journal Article] Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection.2004
- Author(s)
  Nishino Y, Miura T, Miki T, et al.
- Journal Title
  
  Cardiovascular Research 61(3)
  
  Pages: 610-619
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590702
[Presentation] Phosphorylated MLKL, an Executor of Necroptosis, Localized in the Nucleus and Intercalated Disc Plays Distinct Roles in Nonischemic Dilated Cardiomyopathy.2020
- Author(s)
  Fujita Y, Yano T, Nagano N, Nishikawa R, Kamiyama N, Fujito T, Mochizuki A, Koyama M, Kouzu H, Muranaka A, Nagahara D, Tannno M, Miki T, Miura T.
- Organizer
  第84回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Novel regulation of cardiac branched-chain amino acid metabolism through AMP deaminase: A possible therapeutic target for diabetic cardiomyopathy.2020
- Author(s)
  Ogawa T, Kouzu H, Tatekoshi Y, Osanami A, Oshima H, Mizuno M, Kuno A, Igaki Y, Sugawara H, Fujita Y, Sato T, Yano T, Tanno M, Miki T, Miura T.
- Organizer
  European Society of Cardiology Congress 2020
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Inhibition of xanthine oxidase ameliorates functional and metabolic impairment in type 2 diabetic hearts under pressure overload.2020
- Author(s)
  Igaki Y, Osanami A, Tanno M, Sato T, Ogawa T, Yano T, Kouzu H, Miura T
- Organizer
  European Society of Cardiology Congress 2020
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Plasma valine-to-glycine ratio is a novel prognostic maker for adverse events in patients with heart failure2020
- Author(s)
  Kouzu H, Katano S, Yano T, Ohori K, Honma S, Shimomura K, Inoue T, Takamura Y, Takahashi R, Nishikawa R, Nagano N, Koyama M, Fujito T, Hashimoto A, Miura T.
- Organizer
  第84回日本循環器学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Alterations in Mitochondrial Function by SGLT2 Inhibitors2020
- Author(s)
  Miura T
- Organizer
  American Society of Nephrology(ASN) Kidney Week 2020
- Invited
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Pressure overload-induced functional and metabolic impairments in type 2 diabetic hearts are ameliorated by inhibition of xanthine oxidase2019
- Author(s)
  Igaki Y, Tanno M, Kouzu H, Sato T, Tatekoshi Y, Yano T, Kuno A, Miki T, Miura T.
- Organizer
  ESC asia with APCS and AFC
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Functional and metabolic impairments in type 2 diabetic hearts under pressure overload are improved by inhibition of xanthine oxidase.2019
- Author(s)
  Igaki Y, Tanno M, Sato T, Yano T, Kuno A, Miura T.
- Organizer
  日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Activation of necroptotic pasthway by downregulated caspase-8 expression is associated with progression of left ventricular remodeling in nonischemic dilated cardiomyopathy.2019
- Author(s)
  Fujita Y, Yano T, Abe K, Nagano N, Kamiyama N, Fujito T, Mochizuki A, Koyama M, Kouzu H, Muranaka A, Nagahara D, Tanno M, Miki T, Miura T
- Organizer
  ESC congress 2019. Paris, France.
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Synergetic effect of amino acid and ketone metabolism underlies empagliflozin-mediated cardioprotection in the type 2 diabetic heart.2019
- Author(s)
  Kouzu H, Oshima H, Miki T, Kuno A, Sato T, Yano T, Tanno M, Miura T.
- Organizer
  ESC asia with APCS and AFC
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] 糖尿病性心筋症における拡張機能障害は、キサンチンオキシダーゼ阻害により抑制される2019
- Author(s)
  井垣勇祐, 丹野雅也, 神津英至, 佐藤達也,三浦哲嗣
- Organizer
  日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Cardioprotection-Autophagy and Mitochondrial Signaling pathways in cardioprotection2019
- Author(s)
  Tetsuji Miura
- Organizer
  2019 XXIII ISHR World Congress,Beijing, China.
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] mTORC1 suppresses cardiomyocyte necroptosis through autophagy and RIP1 inhibition2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Miura T.
- Organizer
  日本循環器学会基礎医学フォーラム
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Inhibition of mTORC1 supresses necroptosis of cardiomyocytes in a p70S6K-independent mechanism by suppression of p62-RIP1 interaction.2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Miura T.
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] mTORC1 inhibition suppresses necroptosis through restroration of autophagic flux by inhibitory phosphorylation of RIP1 in cardiomyocytes.2018
- Author(s)
  Abe K, Yano T, Miki T, Tanno M, Kuno A, Sato T, Mizuno M, Miura T.
- Organizer
  European Society of Cardiology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Crosstalk between Aberrant mTORC1 Activation and Necroptotic Pathway: a Novel Therapeutic Target in Ischemic Heart Disease2018
- Author(s)
  Yano T, Abe K, Ogasawara M, Kuno A, Tanno M, Miki T, Miura T.
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08079
[Presentation] Dysregulation of miR-301b contributes to diabetic cardiomyopathy via upregulation of AMP deaminasein the vicinity of the sarcoplasmic reticulum2017
- Author(s)
  Tatekoshi Y, Tanno M, Miki T, Kuno A, Yano T, Ohwada W, Abe K, Igaki Y, Fujita Y and Miura T
- Organizer
  American Heart Association 2017 . Anaheim, CA, U.S.A
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Upregulation of AMP deaminase in the vicinity of the SR via translational regulation by miR - 301b contributes to diabetic cardiomyopathy2017
- Author(s)
  Tatekoshi Y, Tanno M, Miki T, Kuno A, Yano T, Ohwada W, Abe K, Igaki Y, Fujita Y, Miura T.
- Organizer
  日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Upregulation of AMP deaminase in the vicinity of sarcoplasmic reticulum through miRNA mediated translational regulation : a novel mechanism of diabetic cardiomyopathy2017
- Author(s)
  Tatekoshi Y, Tanno M, Miki T, Kuno A, Yano T, Ono K, Ohwada W, Mizuno M, Nakata K, Abe K and Miura T
- Organizer
  日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09584
[Presentation] Increased activity of AMP deaminase by decreased interaction with PGM1 and depletion of F1,6P: a novel mechanism of diabetic cardiomyopathy2016
- Author(s)
  Y. Tatekoshi, H. Kouzu, M. Tanno, A. Kuno, S. Ishikawa, T. Yano, T. Miki , M. Ogasawara, T. Tobisawa, K. Ono, S. Muratsubaki, K. Nishizawa, T. Miura
- Organizer
  22nd Congress of International Society for Heart Research
- Place of Presentation
  Buenos Aires, Argentina
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Sequestration of p62 by RIP1 promotes necroptosis through suppression of autophagic flux in cardiomyocytes; a novel cross-talk between autophagy and necroptosis2016
- Author(s)
  Yano T, Ogasawara M, Miki T, Tanno M, Kuno A, Ohno K, Nishizawa K, Owada W, Mizuno M, Suwawara H, Tatekoshi Y, Nakata K, Ishikawa S, Miura T
- Organizer
  European Society of Cardiology Congress 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Excessive ROS production in mitochondria switches off protective mitochondrial kinase signaling.2016
- Author(s)
  Tanno M, Ohwada W, Yano T, Miki T, Kuno A, Ishikawa S, Tatekoshi Y, Nishizawa K, Mizuno M, Miura T.
- Organizer
  4th Congress of Frontiers in Cardiovascular Biology
- Place of Presentation
  Florence, Italy
- Year and Date
  2016-07-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Diabetes and Cardioprotection.2016
- Author(s)
  Miura T
- Organizer
  Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery,
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-05-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Excessive ROS production in mitochondria switches off protective mitochondrial kinase signaling2016
- Author(s)
  Owada W, Tanno M, Yano T, Miki T, Kuno A, Ishikawa S, Tatekoshi Y, Nishizawa K, Mizuno M, Miura T.
- Organizer
  4th Congress of Frontiers in CardioVascular Biology, European Society of Cardiology
- Place of Presentation
  Florence, bItaly
- Year and Date
  2016-07-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] ROS-induced mitochondrial translocation of phosphatases cancelscell-protective signals activated by phosphorylation of mitochondrial protective kinases2016
- Author(s)
  Ohwada W, Tanno M, Yano T, Kuno A, Miki T, Ishikawa S, Tatekoshi Y, Abe K, Ohno K, Mizuno M, Nakata K, Miura T.
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, U.S.A.
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Role of mitochondria in cell death. The mPTP and its regulatory kinases in cardioprotection.2016
- Author(s)
  Miura T
- Organizer
  2016 XXII ISHR World Congress
- Place of Presentation
  Buenos Aires, Argentina
- Year and Date
  2016-04-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Depletion of fructose 1,6-diphosphate but not post-translational modification plays a major role in activation of AMP deaminase in diabetic hearts: a novel mechanism for diabetic cardiomyopathy.2016
- Author(s)
  Y. Tatekoshi, M. Tanno, A. Kuno, S. Ishikawa, T. Yano, T. Miki, M. Ogasawara, T. Tobisawa, K. Ohno, S. Muratsubaki, K. Nishizawa, T. Miura
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Intramolecular inhibition of Ser473 phosphorylation by up-regulated Thr308 phosphorylation in Akt cotributes to enlargement of infarct size by chronic renal failure.2015
- Author(s)
  T. Tobisawa, T. Yano, T. Miki, M. Tanno, A. Kuno, H. Kouzu, M. Ogasawara, S. Muratsubaki, K. Ohno, K. Nishizawa, M. Mizuno, W. Owada, S. Ishikawa, T. Miura.
- Organizer
  88th Scientific Session of American Heart Association:
- Place of Presentation
  Orlando, U.S.A.
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Continuous erythropoietin receptor activation reverses increased myocardial susceptibility to ischemia/reperfusion injury in chronic renal failure.2015
- Author(s)
  K. Nishizawa, T. Yano, T. Miki, M. Tanno, A. Kuno, H. Kouzu, T. Tobisawa, M. Mizuno, H. Sugawara, T. Miura.
- Organizer
  37th Congress of the European Society of Cardiology
- Place of Presentation
  London, UK
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Suppression of Autophagic Flux by Sequestration of p62 Promotes RIP1-mediated Necroptosis in Cardiomyocytes2015
- Author(s)
  Makoto Ogasawara; Toshiyuki Yano; Takayuki Miki; Masaya Tanno; Atsushi Kuno; Hidemichi Kouzu; Toshiyuki Tobisawa; Shingo Muratsubaki; Kohei Ohno; Keitaro Nishizawa; Satoko Ishikawa; Tetsuji Miura
- Organizer
  Scientific Sessions of the American Heart Association 2015
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Acceleration of mPTP re-closure after oxidant stress by mitochondrial K_<ATP> channel activation is achieved by suppression of residual ROS production2014
- Author(s)
  Ogasawara M, Kuno A, Ishikawa S, Tobisawa T, Kouzu H, Yano T, Miki T, Miura T
- Organizer
  The 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Acceleration of mPTP Re-closure after Oxidant Stress by Mitochondrial KATP Channel Activation is Achieved by Suppression of Residual ROS Production2014
- Author(s)
  Ogasawara M, Kuno A, Ishikawa S, Tobisawa T, Kouzu H, Yano T, Miki T, and Miura T.
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Iroquois Homeodomain 5 (Irx5) is Upregulated via Increased ER Stress in Type 2 Diabetic Hearts2013
- Author(s)
  Sato T, Kuno A, Kobayashi T, Miki T, Tanno M, Ishikawa S, Miura T, Tohse N
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-15
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Type 2 diabetes induces ventricular electrical remodeling with a transmural gradient2013
- Author(s)
  Tobisawa T, Sato T, Yuda S, Miki T, Tanno M, Kuno A, Kobayashi T, Akasaka H, Tohse N, Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Promotion of Re-closure of the mPTP Underlies Cardiomyocyte Protection by Activation of the Mitochondrial KATP Channel against ROS-induced Necrosis2013
- Author(s)
  Sunaga D, Kuno A, Ishikawa S, Miki T, Tanno M, Kouzu H, Itoh T, Sato T, Murase H, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Interaction of cyclophilin D with inorganic phosphate carrier during ischemia determines threshold for mPTP opening and reperfusion-induced cell necrosis2013
- Author(s)
  Ito T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Murase H, Ishikawa S, Miura T
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Mechanisms underlying mitochondrial translocation of GSK-3beta, a crucial induces of mitochondrial permeability transition : GSK-3beta activity, interaction with VDAC2 and a mitochondrial targeting sequence2013
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Ogasawara M, Tobisawa T, Murase H, Sato T, Kouzu H, Miki T, Miura T
- Organizer
  American Heart Association BCVS
- Place of Presentation
  Las Vegas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Mechanisms underlying mitochondrial translocation of GSK-3β, a crucial inducer of mitochondrial permeability transition : GSK-3βactivity, interaction with VDAC2 and a mitochondrial targeting sequence2013
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Ogasawara M, Tobisawa T, Murase H, Sato T, Kouzu H, Miki T, Miura T
- Organizer
  Basic Cardiovascular Sciences 2013 (AHA)
- Place of Presentation
  Las Vegas, NV, U.S.A.
- Year and Date
  2013-07-23
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] 地域一般住民における正常高値血糖と血圧高値との組み合わせによる新規糖尿病発症予測に関する検討-端野・壮瞥町研究より-2013
- Author(s)
  大西浩文、斎藤重幸、赤坂　憲、古川哲章、森　満、三浦哲嗣
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25460768
[Presentation] Mechanisms Underlying Mitochondrial Translocation Of GSK-3β, A Crucial Inducer Of Mitochondrial Permeability Transition: GSK-3β Activity, Interaction With VDAC2 And A Mitochondrial Targeting Sequence.2013
- Author(s)
  Tanno M, Kuno A, Ishikawa S, Ogasawara M, Tobisawa T, Murase H, Sato T, Kouzu H, Miki T, and Miura T
- Organizer
  American Heart Association BCVS 2013
- Place of Presentation
  Las Vegas, Nevada, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Role of SIRT3, a Mitochondrial Protein Deacetylase, in Type 2 Diabetic Myocardium2013
- Author(s)
  Kuno A, Itoh T, Sato T, Kouzu H, Tanno M, Miki T, Horio Y, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Type 2 diabetes induces ventricular electrical remodeling with a transmural gradient2013
- Author(s)
  Tobisawa T, Sato T, Yuda S, Miki T, Tanno M, Kuno A, Kobayashi T, Akasaka H, Tohse N, Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2013-09-02
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Insufficient ATP supply due to excessive degradation of adenine nucleotides underlies afterload-induced diastolic dysfunction in type 2 diabetic heart2013
- Author(s)
  Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Murase H, Tobisawa T, Ogasawara M, Miura T
- Organizer
  第17回日本心不全学会
- Place of Presentation
  大宮
- Year and Date
  2013-11-30
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Changes in Titin-based Ventricular Stiffness May Underlie Diastolic Dysfunction Unmasked by Acute Systolic Pressure Overloading in Type 2 Diabetic Hearts2013
- Author(s)
  Kouzu H, Kuno A, Miki T, Tanno M, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-16
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Interaction with VDAC2 promotes mitochondrial translocation of GSK-3beta in a kinase activity-dependent manner and induces cell death.2013
- Author(s)
  Masaya Tanno,Takayuki Miki, Atsushi Kuno , Hidemichi Kouzu, Takahito Itoh , Tatsuya Satoh, Satoko Ishikawa, Daisuke Sunaga, Tetsuji Miura
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the glucagon-like peptide-1 receptor restores myocardial autophagic flux and reduced mortality after myocardial infarction in diabetic rats2013
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T
- Organizer
  Scientific Sessions 2013, the American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Type 2 diabetes induces ventricular electrical remode ling with a transmural gradient2013
- Author(s)
  Tobisawa T, Sato T, Yuda S, Miki T, Tanno M, Kuno A, Kobayashi T, Akasaka H, Tohse N, Miura T.
- Organizer
  European Society of Cardiology
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Interaction of Cyclophilin D with Inorganic Phosphate Carrier during Ischemia Determines Threshold for mPTP Opening and Reperfusion-induced Cell Necrosis2013
- Author(s)
  Ito T, Miki T, Tanno M, Kuno A, Kouzu H, Sato T, Sunaga D, Murase H, Ishikawa S, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-16
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Mechanisms of mPTP re-closure by activation of the mitochondrial ATP-sensitive K+ channel : suppression of GSK-3β-Rieske interaction and ROS production after oxidative stress2013
- Author(s)
  Sunaga D, Tanno T, Ishikawa S, Kuno A, Sato T, Kouzu H, Miki T, Miura T
- Organizer
  The 50th International Society of Heart Research Japanese Section
- Place of Presentation
  San Diego, CA, U.S.A.
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] The role of mitochondria in organ protection2013
- Author(s)
  Miura T
- Organizer
  10^<th> Meeting of Asian Society of Cardiothoracic Anesthesiologists
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the mitochondrial ATP-sensitive potassium channel achieves cell protection by promoting re-closure of the mPTP via suppression of GSK-3β-complex III interaction2013
- Author(s)
  Tanno M, Sunaga D, Miki T, Kuno A, Kouzu H, Sato T, Ishikawa S, Ogasawara M, Tobisawa T, Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2013-09-03
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Insufficient ATP supply due to excessive degradation of adenine nucleotides underlies afterload - induced diastolic dysfu nction in type 2 diabetic heart2013
- Author(s)
  Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Murase H, To bisawa T, Ogasawara M, Miura T
- Organizer
  日本心不全学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Type 2 diabetes induces subendocardium-predominant reduction of transient outward K+ current via downregulation of Kv4.2 and KChIP22013
- Author(s)
  Sato T, Kobayashi T, Kuno K, Murase H, Kouzu H, Tanno T, Miki T, Miura T, Tohse N
- Organizer
  The 50th International Society of Heart Research Japanese Section
- Place of Presentation
  San Diego, CA, U.S.A.
- Year and Date
  2013-06-29
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Activation of the Glucagon-Like Peptide-1 Receptor Restores Myocardial Autophagic Flux and Reduces Mortality After Myocardial Infarction in Diabetic Rats2013
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Tobisawa T, Ogasawara M, Ishikawa S, and Miura T.
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas, Texas, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Interaction with VDAC2 Promotes Mitochondrial Translocation of GSK3Βin a Kinase Activity-Dependent Manner and Induces Cell Death2013
- Author(s)
  Tanno M, Ishikawa S, Miki T, Kuno A, Kouzu H, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-16
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Interaction of cyclophilin D with inorganic phosphate carrier during ischemia determines threshold for mPTP opening and reperfusion-induced cell necrosis.2013
- Author(s)
  Takahito Ito,Hidemichi Kouzu , Takayuki Miki , Masaya Tanno , Atsushi Kuno , Tatsuya Satoh , Daisuke Sunaga , Hiromichi Murase , Satoko Ishikawa , Tetsuji Miura
- Organizer
  The 77th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the glucagon-like peptide-1 receptor restores myocardial autophagic flux and reduces mortality after myocardial infarction in diabetic rats2013
- Author(s)
  Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T
- Organizer
  American Heart Association 2013
- Place of Presentation
  Dallas, TX, U.S.A.
- Year and Date
  2013-11-17
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Interaction with VDAC2 promotes mitochondrial traslocation of GSK-3beta in a kinase activity-dependent manner and induces cell death2013
- Author(s)
  Tanno M, Miki T, Kuno A, Kouzu H, Itoh T, Sato T, Ishikawa S, Sunaga D, Miura
- Organizer
  The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of the mitochondrial ATP-sensitive potassium channel achieves cell protection by promoting re-closure of the mPTP via suppression of GSK-3beta - complex III interaction2013
- Author(s)
  Sunaga D, Tanno M, Miki T, Kuno A, Kouzu H, Sato T, Ishikawa S, Ogasawara M, Tobisawa T, and Miura T
- Organizer
  European Society of Cardiology Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] The Role of mTORC2 and Ribosomal Protein S6 in Cardioprotective Signaling2013
- Author(s)
  Yano T, Felito M, Tobisawa T, Ogasawara M, Murase H, Kuno A, Tanno M, Miki T, Steenbergen C, Miura T
- Organizer
  第17回日本心不全学会
- Place of Presentation
  大宮
- Year and Date
  2013-11-28
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Facilitated re-closure of the mitochondrial permeability transition pore underlies protection of cardiomyocytes from ROS-induced necrosis by activation of the mitochondrial ATP-sensitive K^+ channel2012
- Author(s)
  Suanga D, Kuno A, Ishikawa S, Miki T, Tanno M, Kouzu H, Itoh T, Sato T, Murase H, Miura T
- Organizer
  Scientific Sessions 2012, the American Heart Association
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Titin-isoform shift may underlie distinct ventricular responses to pressure and volume overloads in type 2 diabetic heart2012
- Author(s)
  Kouzu H, Kuno A, Miki T, Tanno M, Itoh T, Sato T, Sunaga D, Murase H, Miura T
- Organizer
  Scientific Sessions 2012, the American Heart Association
- Place of Presentation
  Los Angeles, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Facilitated Re-Closure of the Mitochondrial Permeability Transition Pore Underlies Protection of Cardiomyocytes from ROS-Induced Necrosis by Activation of the Mitochondrial ATP-Sensitive K+ Channel2012
- Author(s)
  Daisuke Sunaga, Atsushi Kuno, Satoko Ishikawa, Takayuki Miki, Masaya Tannno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Hiromichi Murase, and Tetsuji Miura
- Organizer
  Scientific Sessions 2012, the American Heart Assocaition
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Resveratrol, a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down-regulation of p3002012
- Author(s)
  Kuno A, Tanno M, Miki T, Ishikawa S, Horio Y, Miura T.
- Organizer
  European Society of Cardiology Congress 2012
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Titin-isoform Shift May Underlie Distinct Ventricular Responses to Pressure and Volume Overloads in Type 2 Diabetic Heart2012
- Author(s)
  Hidemichi Kouzu, Atsushi Kuno, Takayuki Miki, Masaya Tanno, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga, Hiromichi Murase, and Tetsuji Miura
- Organizer
  Scientific Sessions 2012, the American Heart Assocaition
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Mitochondria and cardioprotection2012
- Author(s)
  Miura T
- Organizer
  The 64^<th> Annual Meeting of Korean Physiological Society
- Place of Presentation
  Busan, Korea
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down- regulation of p3002012
- Author(s)
  Kuno A, Tanno M, Miki T, Ishikawa S, Horio Y, Miura T
- Organizer
  European Society of Cardiology Congress 2012
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-08-26
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Phosphorylation of GSK-3b at Ser9 inhibits its translocation to mitochondria and attenuates lethal ROS production by mitochondria2012
- Author(s)
  Masaya Tanno, Takayuki Miki, Atsushi Kuno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga and Tetsuji Miura
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Mitochondria and cardioprotection2012
- Author(s)
  Tetsuji Miura
- Organizer
  The 64th Annual Meeting of Korean Physiological Society
- Place of Presentation
  Busan, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] UPR In Endoplasmic Reticulum vs. UPR In Mitochondria In Diabetic Myocardium: Which Is Responsible For Deficient Regulation Of Mitochondrial Permeability Transition Pores?2011
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno T, Kuno A, Sato T, Sunaga D, Ishikawa S, Miura T
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] GSK-3beta translocation to mitochodnria by oxidant stress in a kinase activity-dependent manner and contributes to lethal ROS production2011
- Author(s)
  Tanno M, Kuno A, Itoh T, Sato T, Ishikawa S, Sunaga D, Miura T
- Organizer
  Scientific Sessions 2011, the American Heart Association
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] GSK-3β Translocates to Mitochondria by Oxidant Stress in a Kinase Activity-Dependent Manner and Contributes to Lethal ROS Production2011
- Author(s)
  Tanno M, Kuno A, Kouzu H, Itoh T, Sato T, Ishikawa S, Sunaga D, Miura T.
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] GSK-3b translocates to mitochondria by oxidant stress in a kinase activity-dependent manner and contributes to lethal ROS production2011
- Author(s)
  Masaya Tanno, Takayuki Miki, Atsushi Kuno, Hidemichi Kouzu, Takahito Itoh, Tatsuya Sato, Daisuke Sunaga and Tetsuji Miura
- Organizer
  Scientific Sessions 2011, American Heart Association
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] UPR in endoplasmic reticulum vs. in mitochondria in diabetic myocardium : which is responsible for deficient regulation of mitochondrial permeability transition pores?2011
- Author(s)
  Itoh T, Kouzu H, Miki T, Tanno M, Kuno A, Sato T, Sunaga D, Ishikawa S, Miura
- Organizer
  Scientific Sessions 2011, the American Heart Association
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-23591086
[Presentation] Activation of Sirt1 suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via p roteasome-mediated p300 degradation.2010
- Author(s)
  Kuno A, Tanno M, Ishikawa S, Horio Y, Miura T.
- Organizer
  83^<rd> Scientific Session of American Heart Association
- Place of Presentation
  Chicago,U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Activation of Sirtl suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via proteasome-mediated p300 degradation.2010
- Author(s)
  Kuno A, Tanno M, Ishikawa S, Horio Y, Miura T.
- Organizer
  83^<rd> Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Increased ER stress is a fundamental mechanism for impairment of cardioprotective signaling in type 2 diabetes.2010
- Author(s)
  Kouzu H, Itoh T, Miki T. Tanno M, Yano Y, Sato T, Takada A, Sunaga D, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Ventricular dysfunction and blunted response to adrenergic stimulation in obese type 2 diabetes predispose to fatal heart failure after infarction : Possible involvement of microRNA-1 down-regulation.2010
- Author(s)
  Takada A, Miki T Tanno M, Suzuki H, Yano T, Kuno A, Itoh T, Sato T, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Enhancement of cyclophilin-D-ANT interaction upon reperfusion in hypertensive hypertrophied hearts : a target of cardioprotection against ischemia/reperfusion injury.2010
- Author(s)
  Yano T, Tanno M Itoh T, Miura T.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Mitochondria is a critical compartment for phospho-GSK-3β to afford cytoprotection against ischemia/reperfusion injury.2010
- Author(s)
  Sato T, Miura T, Tanno M, Miki T, Takada A, Itch T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Regulation of mitochondrial GSK-3β for cell survival is impaired by multiple mechanisms in the diabetic myocardium2010
- Author(s)
  Tetsuji Miura
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin43-dependent mitochondrial GSK-3β phosphorylation in protection of cardiomyocyte against necrosis.2010
- Author(s)
  Ishikawa S, Miki T, Tanno M, Miura T.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Glycogen synthase kinase-3β as a therapeutic target for cardiomyocyte protection.2010
- Author(s)
  Miura T. Miki T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin-43 contributes to transmission of MitoK_ATP channel-derived redox signal to Akt-GSK-3β pathway in cardiomyocyte protection afforded by G protein-coupled receptors.2010
- Author(s)
  Ishikawa S, Kuno A, Miki T, Tanno T. Yano T, Kouzu H, Sato T, Sunaga D, Miura T.
- Organizer
  83rd Scientific Sessions of American Heart Association.
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Role of GSK-3β in negative regulation of the mPTPs by the mitochondrial K_ATP channel.2010
- Author(s)
  Itch T, Terashima Y, Miki T, Miura T, Shimamoto K.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Activation of histone/protein deacetylase SIRT1 by resveratrol induces MnSOD up-regulation via FOXO3a and improves survival of heart failure animals.2009
- Author(s)
  Kuno A, Tanno M, Miura T, Horio Y, Shimamoto K.
- Organizer
  31^<st> Congress of the European Society of Cardiology
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Jak2-mediated cardioprotective signaling is impaired in diabetic hearts by AT_1 receptormediated up-regulation of calcineurin.2009
- Author(s)
  Miura T, Hotta H, Miki T, Yano T, Ishikawa S, Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Enhanced ANT-cyclophilin-D interaction underlies reduced anti-infarct tolerance and loss of protective response to erythropoietin in hypertensive hypertrophied hearts.2009
- Author(s)
  Miki T. Yano T, Miura T, Tanno M. Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] The SIRT1 activator resveratrol suppresses cardiomy ocyte hypertrophy by promoting histone H3 Lys9 deacetylation and tri-methylation.2009
- Author(s)
  Kuno A, Tanno M, Yano T, Takada A, Miura T, Horio Y, Shimamoto K.
- Organizer
  82^<nd> Scientific Session of American Heart Association
- Place of Presentation
  Orlando, U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Role of GSK-3β in negative regulation of mitochondrial permeability transition pore by the mitochondrial K_ATP channel.2009
- Author(s)
  Miura T, Terashima Y, Maas O, Miki T, Tanno M, Ishikawa S, Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Activation of histone/protein deacetylase SIRTI by resveratrol induces MnSOD upregulation via FOXO3a and improves survival of heart failure animals.2009
- Author(s)
  Kuno A, Tanno M. Miura T, Horio Y, Shimamoto K.
- Organizer
  31st Congress of the European Society of Cardiology.
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Resveratrol, an activator of protein deacetylase SIRT1, suppresses oxidative stress-induced cell death by upregulating MnSOD expression through transactivation of Foxo3a.2008
- Author(s)
  Kuno A, Tanno M Miura T, Horio Y, Shimamoto K.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] ER stress contributes to dysregulation of GSK-3β-mediated suppression of mitochondrial permeability transition in diabetic hearts.2008
- Author(s)
  Miki T, Tanno M, Kuno A, Yano T, Sato T, Hotta H, Ichikawa S, Miura T.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Resveratrol, an activator of protein deacetylase SIRT1, suppresses oxidative stress-induced cell death by upregulating MnSOD expression through transactivation of FOXO3a .2008
- Author(s)
  Kuno A, Tanno M, Miura T, Horio Y, Shimamoto K.
- Organizer
  81^<st> Scientific Session of America n Heart Association
- Place of Presentation
  New Orleans,U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Connexin43-dependent and-independent mechanisms of mitochondrial GSK-3β phosphorylation in protection of cardiomyocyte against necrosis.2008
- Author(s)
  Tetsuji Miura
- Organizer
  Scientific Sessions 2008 of the American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-10
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Connexin43-dependent and-independent mechanisms of mitochondrial GSK-3β phosphorylation in protection of cardiomyocyte against necrosis.2008
- Author(s)
  Ishikawa S, Miura T, Tanno M, Kuno A, Sato T, Hotta H, Terashima Y, Miki T.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Activation of a protein deacetylase,SIRT1, by resveratrol suppresses progression of heart failure and improves survival by up-regulation of Mn-SOD.2008
- Author(s)
  Tanno M, Kuno A, Miki T, Miura T, Horio Y, Shimamoto K.
- Organizer
  81^<st> Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Activation of a protein deacetylase, SIRTI, by Resveratol suppresses progression of heart failure and improves survival by up-regulation of Mn-SOD.2008
- Author(s)
  Tanno M Kuno A, Miki T. Miura T. Horio Y, Shimamoto K.
- Organizer
  81st Scientific Sessions of American Heart Association.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-20590870
[Presentation] Roles of p38MAPK and PKC in connexin43-mediated gap junction modulation by ischemic preconditioning.2007
- Author(s)
  Tetsuji Miura, et al.
- Organizer
  19^<th> World Congress of the International Society for Heart Keseareh
- Place of Presentation
  Bologna, Italy
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Roles of p38MAPK and PKC in connexin43-mediated gap junction modulation by ischemic preconditioning.2007
- Author(s)
  Tetsuji Miura, et al.
- Organizer
  19^<th> World Congress of the International Society for Heart Research
- Place of Presentation
  Bologna, Italy
- Year and Date
  2007-06-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590781
[Presentation] Role of mitochondrial GSK-3beta in myocardial ischemia/reperfusion injury
- Author(s)
  Miura T
- Organizer
  ESC 2nd International Symposium on “Frontiers in Cardio-vascular Research
- Place of Presentation
  Huatulco-Oaxaca, Mexico
- Year and Date
  2014-11-23 – 2014-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-26461133
[Presentation] Mitochondrial translocation of GSK-3β, a trigger of mitochondrial permeability transition, is mediated by its N-terminal domain and promoted by interaction with VDAC2.
- Author(s)
  Tanno M, Ishikawa S, Miki T, Kuno A, Kouzu H, Yano T, Miura T
- Organizer
  Frontiers in Cardiovascular Biology, 3rd meeting of the ESC council on basic cardiovascular science
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-26461132
[Presentation] Accumulation of p62 by dysregulation of autophagy induces RIP1-dependent necroptosis in cardiomyocytes: a novel interplay between autophagy and necroptosis.
- Author(s)
  Ogasawara M, Yano T, Miki T, Tanno M, Kuno A, Kouzu H, Murase H, Tobisawa T, Muratsubaki S, Nishizawa K, Mizuno M, Ishikawa S, Miura T.
- Organizer
  American Heart Association, Scientific Sessions 2014
- Place of Presentation
  Chicago, Illinois, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461133

1. TANNO Masaya (00398322)

# of Collaborated Projects: 9 results

# of Collaborated Products: 123 results
2. MIKI Takayuki (00336405)

# of Collaborated Projects: 8 results

# of Collaborated Products: 84 results
3. 矢野俊之 (40444913)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
4. HORIO Yoshiyuki (30181530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. OGAWA Takashi (80240927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Ohnishi Hirofumi (20359996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. UNO Kikuya (50305223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKAMOTO Jun (40336392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 森満 (50175634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 斉藤重幸 (60253994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUNO Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
12. 佐藤達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 古橋眞人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 斎藤重幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田中希尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 神津英至

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Miura Tetsuji 三浦 哲嗣

MIURA Tetsuji 三浦 哲嗣

Research Projects

Research Products

Co-Researchers

Intracellular signal transduction regulating necroptosis of cardiomyocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Cross-talk of cardiomyocyte necroptosis and autophagy in heart failurePrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Development of novel therapeutic approach for diabetic cardiomyopathy by modification of AMP deaminase activity.

Principal Investigator

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Novel therapeutic approach for heart failure by suppression of mitochondrial translocation of GSK-3beta

Principal Investigator

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Role of mitochondrial permeability transition in necroptosis of the cardiomyocytePrincipal Investigator

Principal Investigator

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Research Institution

Establishment of classification and regression tree model for assessing of a risk for future occurence of life-style related disease using a community-based cohort data.

Principal Investigator

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Research Institution

Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protein kinases regulating the mitochondrial permeability transition porePrincipal Investigator

Principal Investigator

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Research Institution

Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure

Principal Investigator

Project Period (FY)

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Research Institution

Role of connexin-43 in protective signaling incardiomyocytePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Roles of connexin-43 in cardiomyocyte tolerance against ischemic injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Intracellular Signaling Mechanisms Regulating Functions and Expression of the Gap Junction in Ischemic MyocardiumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modification of gap junctions during myocardial ischemia and its significance in myocardial necrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Miura Tetsuji 三浦哲嗣

MIURA Tetsuji 三浦哲嗣