Ashino Takashi 芦野隆

… Alternative Names

ASHINO Takashi 芦野隆

芦野隆アシノタカシ

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Researcher Number	00338534
Other IDs
Affiliation (Current)	2025: 昭和大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 昭和大学, 薬学部, 准教授 2016 – 2019: 昭和大学, 薬学部, 講師 2011 – 2015: 昭和大学, 薬学部, 助教 2007 – 2008: 昭和大学, 薬学部, 助教 2001 – 2004: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 59040:Nutrition science and health science-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Environmental pharmacy / Environmental pharmacy
Keywords	Principal Investigator 酸化ストレス / 血管平滑筋細胞 / 動脈硬化 / Nrf2 / 血管内膜肥厚 / 活性酸素 / マクロファージ / 炎症性サイトカイン / 肝線維化 / 非アルコール性脂肪性肝疾患 … More / Akt / PDGF / サルフェンイオウ / 活性イオウ分子 / IQGAP1 / 骨髄細胞 / Keap1 / Nrf2/Keap1 / アポトーシス / 細胞増殖 / 血小板由来増殖因子 / 細胞遊走 … More Except Principal Investigator シトクロムP450 / CYP2B / STAT / LPS / BCG / MAPK / サイトカイン / ヘムオキシゲナーゼ-1 / CAR / Nrf2 / Constitutive androstane receptor / Cocaine / Heine oxygenase-1 / HTLV-I Tg mouse / Lipopolysaccharide / Cytokine / Cytochrome P450 / オーラノフィン / 炎症性サイトカイン / 関節リウマチ / 肝障害 / 酸化ストレス / ヘムオシゲナーゼ-1 / コカイン / HTLV-I Tgマウス / リポポリサッカライド / oxidative stress / cytokine / heme oxygenese-1 / cytochromeP450 / IL-6 / TNFα / 酸化的ストレス / 血管平滑筋細胞 / 動脈硬化 / 肝傷害 / 硫化水素 / 一酸化炭素 / ガス状物質 / Cyp2b10 / マウス / NADPH:quinone oxidoreductase-1 / heme oxygenase-1 / 誘導型-酸化窒素合成酵素 / カドミウム / 5-フルオロウラシル / トキシコゲノミクス / ヘムオキシゲナーゼー1 Less

Protective role of the oxidative stress response system against liver fibrogenesis in NAFLD/NASHPrincipal Investigator
- Principal Investigator
  
  芦野隆
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Showa University
Role of reactive sulfur species in vascular redox regulation and inhibition of arteriosclerosisPrincipal Investigator
- Principal Investigator
  
  Ashino Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Showa University
Elucidation of a switching mechanism between production and extinction of reactive oxygen species on vascular remodeling after injuryPrincipal Investigator
- Principal Investigator
  
  Ashino Takashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Showa University
Mechanism of inhibition of vascular neointimal hyperplasia by oxidative stress responsive factor through functional reguration of vascular progenitor cellsPrincipal Investigator
- Principal Investigator
  
  Ashino Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Showa University
Role of the redox-sensitive transcription factor Nrf2 in vascular neointimal hyperplasiaPrincipal Investigator
- Principal Investigator
  
  ASHINO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Showa University
Mutual regulation of physiological gases by xenobiotics
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
トキシコゲノミクスを基盤とした新規生体防御因子の探索
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
Elucidation of defensive mechanism against xenobiotics in cytokine knock out and pathologic model mice
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
Changes in cytochrome P450 and stress responsive proteins under oxidative stress
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa university

[Journal Article] Toxicity manifestations and sex differences due to MARTA olanzapine2023
- Author(s)
  Natsumi Hattori-Usami, Asuka Kaizaki-Mitsumoto, Takashi Ashino, Masayuki Yamamoto, Satoshi Numazawa
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 4 Pages: 191-202
- DOI
  10.2131/jts.48.191
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08136, KAKENHI-PROJECT-23K08429
[Journal Article] Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes2023
- Author(s)
  Miyoshi Tatsuro、Keller Brian C.、Ashino Takashi、Numazawa Satoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 10 Pages: e0291905-e0291905
- DOI
  10.1371/journal.pone.0291905
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08429, KAKENHI-PROJECT-21K08136
[Journal Article] Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-62023
- Author(s)
  Ashino Takashi、Nakamura Yuki、Ohtaki Hirokazu、Iwakura Yoichiro、Numazawa Satoshi
- Journal Title
  
  International Immunopharmacology
  
  Volume: 117 Pages: 110039-110039
- DOI
  10.1016/j.intimp.2023.110039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19737, KAKENHI-PROJECT-22K09317, KAKENHI-PROJECT-21K08136, KAKENHI-PROJECT-23K21623
[Journal Article] Interleukin-6 regulates the expression of hepatic canalicular efflux drug transporters after cecal ligation and puncture-induced sepsis: A comparison with lipopolysaccharide treatment2023
- Author(s)
  Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
- Journal Title
  
  Toxicology Letters
  
  Volume: 374 Pages: 40-47
- DOI
  10.1016/j.toxlet.2022.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08136, KAKENHI-PROJECT-22K09317, KAKENHI-PROJECT-22K19737, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-23K21623
[Journal Article] Reactive sulfur species inhibit the migration of PDGF-treated vascular smooth muscle cells by blocking the reactive oxygen species-regulated Akt signaling pathway2021
- Author(s)
  Ishii Shunichi、Ashino Takashi、Fujimori Hiroki、Numazawa Satoshi
- Journal Title
  
  Free Radical Research
  
  Volume: - Issue: 2 Pages: 1-12
- DOI
  10.1080/10715762.2021.1887485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06633, KAKENHI-PROJECT-21K08136
[Journal Article] Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality2021
- Author(s)
  Yoshitaka Yamazaki, Mikako Terashima-Hasegawa, Atsufumi Manabe, Toshikazu Shiba, Yumi Kawazoe, Takashi Ashino, Masahiro Hosonuma, Satoshi Numazawa
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 8 Issue: 3 Pages: 89-96
- DOI
  10.2131/fts.8.89
- NAID
  130008068071
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K24079, KAKENHI-PROJECT-21K08136
[Journal Article] Regulation of cytochrome P450 expression in oxidative stress-associated pathological conditions2021
- Author(s)
  芦野隆
- Journal Title
  
  Journal of The Showa University Society
  
  Volume: 81 Issue: 5 Pages: 387-394
- DOI
  10.14930/jshowaunivsoc.81.387
- NAID
  130008142372
- ISSN
  2187-719X, 2188-529X
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08136
[Journal Article] Nrf2 Antioxidative System is Involved in Cytochrome P450 Gene Expression and Activity: A Delay in Pentobarbital Metabolism in Nrf2-Deficient Mice2020
- Author(s)
  Ashino Takashi、Yamamoto Masayuki、Numazawa Satoshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 48 Issue: 8 Pages: 673-680
- DOI
  10.1124/dmd.120.000010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K06633, KAKENHI-PROJECT-18K08115
[Journal Article] Inorganic polyphosphate protects against lipopolysaccharide-induced lethality and tissue injury through regulation of macrophage recruitment2019
- Author(s)
  Terashima-Hasegawa Mikako、Ashino Takashi、Kawazoe Yumi、Shiba Toshikazu、Manabe Atsufumi、Numazawa Satoshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 159 Pages: 96-105
- DOI
  10.1016/j.bcp.2018.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06633, KAKENHI-PROJECT-18K08115
[Journal Article] Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffolding protein: role in PDGF-induced VSMC migration and vascular remodeling2018
- Author(s)
  Ashino Takashi、Kohno Takashi、Sudhahar Varadarajan、Ash Dipankar、Ushio-Fukai Masuko、Fukai Tohru
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 315 Issue: 6 Pages: C850-C862
- DOI
  10.1152/ajpcell.00230.2018
- NAID
  130007431918
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08115
[Journal Article] Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injuryNrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury2016
- Author(s)
  Ashino T, Yamamoto M, Numazawa S.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 26291-26291
- DOI
  10.1038/srep26291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15K07973, KAKENHI-PROJECT-15K19398
[Journal Article] Chemical-induced coordinated and reciprocal changes in heme metabolism, cytochrome P450 synthesis and others in the liver of humans and rodents2016
- Author(s)
  Yoshida T, Ashino T, Kobayashi Y
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: Special Pages: SP89-SP103
- DOI
  10.2131/jts.41.SP89
- NAID
  130005450522
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19398
[Journal Article] Nrf2酸化ストレス応答系による血管内膜肥厚制御2015
- Author(s)
  芦野隆、沼澤聡
- Journal Title
  
  Journal of The Showa University Society
  
  Volume: 75 Issue: 2 Pages: 120-125
- DOI
  10.14930/jshowaunivsoc.75.120
- NAID
  130005108373
- ISSN
  2187-719X, 2188-529X
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07973, KAKENHI-PROJECT-15K19398
[Journal Article] Inhibitory effect of synthetic cannabinoids on CYP1A activity in mouse liver microsomes2014
- Author(s)
  Ashino T, Hakukawa K, Itoh Y, Numazawa S
- Journal Title
  
  J Toxicol Sci
  
  Volume: 39 Pages: 815-820
- NAID
  130004704487
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790785
[Journal Article] Possible involvementof nuclear factor erythroid 2-related factor 2in the gene expression of Cyp2b10and Cyp2a52014
- Author(s)
  Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, Numazawa S
- Journal Title
  
  Redox Biology
  
  Volume: 10 Pages: 284-288
- DOI
  10.1016/j.redox.2013.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790785
[Journal Article] IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury2013
- Author(s)
  Kohno T, Urao N, Ashino T, Sudhahar V, Inomata H, Yamanaka-Tojo M, McKinney RD, Fukai T, Ushio-Fukai M
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 305 Issue: 6 Pages: C591-C600
- DOI
  10.1152/ajpcell.00011.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790785
[Journal Article] Redox-sensitive transcription factor Nrf2 regulates vascular smooth muscle cell migration and neointimal hyperplasia2013
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 33 Issue: 4 Pages: 760-768
- DOI
  10.1161/atvbaha.112.300614
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590143, KAKENHI-PROJECT-23659068, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790785
[Journal Article] Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.2013
- Author(s)
  Kohno T
- Journal Title
  
  Arterioscler Thromb Vasc Biol.
  
  Volume: Apr; 33　(4) Issue: 4 Pages: 805-813
- DOI
  10.1161/atvbaha.112.300862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20221010, KAKENHI-PROJECT-24790785, KAKENHI-PROJECT-25220205
[Journal Article] Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.2012
- Author(s)
  Kojima M, Ashino T, Yoshida T, Iwakura Y, Degawa M.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35 Pages: 246-250
- NAID
  130001872300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice2012
- Author(s)
  Kojima M, Ashino T, Yoshida T, Iwakura Y, Degawa M
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(2) Pages: 246-250
- NAID
  130001872300
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22382320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver2011
- Author(s)
  Kojima M, Ashino T, Yoshida T, Iwakura Y, Degawa M
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34(10) Pages: 1644-1647
- NAID
  130001086603
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21963511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1.2011
- Author(s)
  Ashino T, Sugiuchi J, Uehara J, Naito-Yamamoto Y, Kenmotsu S, Iwakura Y, Shioda S, Numazawa S, Yoshida T.
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36 Pages: 635-643
- NAID
  10029481491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver.2011
- Author(s)
  Kojima M, Ashino T, Yoshida T, Iwakura Y, Degawa M.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 1644-1647
- NAID
  130001086603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-12011
- Author(s)
  Ashino T, Sugiuchi J, Uehara J, Naito-Yamamoto Y, Kenmotsu S, Iwakura Y, Shioda S, Numazawa S, Yoshida T
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36(5) Pages: 635-643
- NAID
  10029481491
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22008538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659068
[Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages2008
- Author(s)
  T. Ashino, R. Yamanaka, M. Yamamoto, H. Shimokawa, K. Sekikawa, Y. Iwakura, S. Shioda, S. Numazawa, T. Yoshida
- Journal Title
  
  Molecular Immunology 45
  
  Pages: 2106-2115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659030
[Journal Article] Negaive Feedbavk regulation of lipopolysaccharide-induced inducible nitric oxide synthase gane expression by heme oxygenase-l induction2008
- Author(s)
  T. Ashino, R. Yamanaka, et. al
- Journal Title
  
  Molecular Immunology 45
  
  Pages: 2105-2115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659030
[Journal Article] Involvement of interleukin-G and tumor necrosis factor a in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T
- Journal Title
  
  Drug Metabolism and Disposition 32(7)
  
  Pages: 707-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
- Journal Title
  
  Drug Metabolism and Disposition Vol.32, No.7
  
  Pages: 707-714
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
- Journal Title
  
  Drug Metabolism and Disposition Vol.32,No.7
  
  Pages: 707-714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Presentation] NAFLD/NASHによる炎症性サイトカイン非依存的シトクロムP450遺伝子発現低下2024
- Author(s)
  芦野隆，千葉莉沙子，村田百奈美，柴田佳太，野部浩司，岩倉洋一郎，沼澤聡
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 盲腸結紮穿刺誘発敗血症による肝薬物トランスポーター遺伝子発現低下におけるインターロイキン-6の関与2023
- Author(s)
  芦野隆，中村祐輝，大滝博和，岩倉洋一郎，沼澤聡
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] Inhibitory role of reactive sulfur species in PDGF-induced vascular smooth muscle cell migration2023
- Author(s)
  Ashino T, Ishii S, Numazawa S
- Organizer
  10th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] メカニカルストレス付与による化学療法誘発性末梢神経障害モデルマウスにおけるオキシトシン発現の解析2023
- Author(s)
  渡辺佳愛子，篠内良介，佐々木晶子，柴田佳太，古林創史，芦野隆，辻まゆみ，木内祐二，野部浩司
- Organizer
  第149回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 5-フルオロウラシル誘発骨髄抑制におけるNrf2酸化ストレス応答系の役割2023
- Author(s)
  芦野隆，赤池哉太，千葉莉沙子，山本雅之，沼澤聡
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] メカニカルストレスによる化学療法誘発性末梢神経障害モデルマウスの皮膚構造改善効果の検討2023
- Author(s)
  篠内良介，佐々木晶子，柴田佳太，古林創史，芦野隆，高木孝士，辻まゆみ，木内祐二，野部浩司
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 化学療法誘発性末梢神経障害 (CIPN) モデルマウスを用いたハンドセラピー施術による神経障害改善機序の検討2022
- Author(s)
  村﨑帆乃香，篠内良介，佐々木晶子，柴田佳太，古林創史，芦野隆，坂井信裕，山口真帆，佐藤ゆり絵，細沼雅弘，髙木孝士，辻まゆみ，野部浩司，木内祐二
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 敗血症モデルマウスを用いた肝シトクロム450遺伝子発現低下におけるインターロイキン-6の役割2022
- Author(s)
  芦野隆，中村祐輝，大滝博和，岩倉洋一郎，沼澤聡
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 化学療法誘発性末梢神経障害 (CIPN) モデルマウスを用いたハンドセラピー施術による神経障害改善効果の解明2021
- Author(s)
  篠内良介，佐々木晶子，柴田佳太，古林創史，芦野隆，坂井信裕，山口真帆，佐藤ゆり絵，細沼雅弘，髙木孝士，辻まゆみ，野部浩司，木内祐二
- Organizer
  第53回日本臨床分子形態学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] 血小板由来増殖因子による血管平滑筋細胞遊走におけるサルフェンイオウの役割2021
- Author(s)
  芦野隆，石井俊一，沼澤聡
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K08136
[Presentation] MARTAオランザピン誘発酸化ストレスへの応答性には性差がある2021
- Author(s)
  服部夏実，光本（貝崎）明日香，芦野隆，山本雅之，沼澤聡
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 盲腸結紮穿刺誘発敗血症による肝シトクロムP450発現変動における炎症性サイトカインの役割2020
- Author(s)
  芦野隆，中村祐輝，大滝博和，岩倉洋一郎，沼澤聡
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 血小板由来増殖因子による血管平滑筋細胞遊走における活性イオウの役割と抑制メカニズム2020
- Author(s)
  石井　俊一、渡部　真由、芦野　隆、沼澤　聡
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 血小板由来増殖因子による血管平滑筋遊走における活性イオウ分子の遊走抑制のメカニズム2020
- Author(s)
  石井俊一，藤森央基，渡部真由，芦野隆，沼澤聡
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 盲腸結紮穿刺誘発敗血症による肝薬物排泄トランスポーター発現変動における炎症性サイトカインの役割2020
- Author(s)
  芦野　隆、石坂　優太、栁町　有人、中村　祐輝、大滝　博和、岩倉　洋一郎、沼澤　聡
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] Nrf2/Keap1 oxidative stress-responsive system inhibits neointimal hyperplasia response to vascular injury by regulating vascular smooth muscle cell migration and apoptosis2019
- Author(s)
  Ashino T, Yamamoto M, Numazawa S
- Organizer
  IUTOX 15th International Congress of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 腹膜炎モデルにおける長鎖分割ポリリン酸の致死率改善効果2019
- Author(s)
  山崎　喜貴、芦野　隆、川添　祐美、柴　肇一、沼澤　聡
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 酸化ストレス防御因子Nrf2によるマクロファージおよび血管平滑筋細胞の接着、遊走制御を介した動脈硬化抑制機能2019
- Author(s)
  芦野　隆、山本　雅之、沼澤　聡
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 炎症性サイトカイン遺伝子欠損マウスを用いた盲腸結紮穿刺誘発性敗血症におけるシトクロムP450変動の検討2019
- Author(s)
  中村　祐輝、芦野　隆、大滝　博和、渡邊　潤、岩倉　洋一郎、沼澤　聡
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 長鎖ポリリン酸のマクロファージ活性化抑制作用とエンドトキシンショックモデルの致死率改善効果2018
- Author(s)
  寺島　実華子、芦野　隆、川添　祐美、柴　肇一、沼澤　聡、真鍋　厚史
- Organizer
  第149回日本歯科保存学会2018年度秋季学術大会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 無機ポリリン酸によるマクロファージ遊走抑制を介したリポポリサッカライド誘発致死性ショック保護作用2018
- Author(s)
  芦野　隆、寺島　実華子、川添　祐美、柴　肇一、真鍋　厚史、沼澤　聡
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] 銅トランスポーターATP7Aによるスキャホールドタンパク質IQGAP1結合を介した血管平滑筋細胞遊走制御と新生内膜肥厚への役割2018
- Author(s)
  芦野　隆、河野　隆志、Sudhahar V、Ash D、深井　真寿子、深井　透
- Organizer
  第４５回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K08115
[Presentation] エンドトキシンショックによる多臓器障害における長鎖分割ポリリン酸の保護効果2018
- Author(s)
  芦野隆、寺島実華子、川添祐美、柴肇一、真鍋厚史、沼澤聡
- Organizer
  日本薬学会第１３８年会
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] エンドトキシンショックにおける長鎖分割ポリリン酸の致死率低下効果2017
- Author(s)
  寺島実華子、芦野隆、田中大貴、瀧上彩香、川添祐美、柴肇一、真鍋厚史、沼澤聡
- Organizer
  第４４回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Nrf2欠損による薬物代謝能低下とシトクロムP450誘導能の低下2017
- Author(s)
  芦野隆、山本雅之、沼澤聡
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Nrf2 欠損マウスにおけるペントバルビタールの薬効延長とCYP2B遺伝子発現低下2017
- Author(s)
  芦野　隆、山本　雅之、沼澤　聡
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際センター（仙台）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Nrf2欠損によるペントバルビタール代謝遅延とシトクロムP450遺伝子発現抑制2017
- Author(s)
  芦野隆、山本雅之、沼澤聡
- Organizer
  第４４回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Nrf2/Keap1酸化ストレス応答システムによるマクロファージおよび血管平滑筋細胞遊走制御を介した血管内膜肥厚抑制機構2016
- Author(s)
  綿山　真由、甘利　美佳、吉川　佳那、芦野　隆、山本　雅之、沼澤　聡
- Organizer
  フォーラム２０１６衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学（東京）
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Nrf2 システムによる血管細胞アポトーシス調節を介した血管内膜肥厚抑制機能2016
- Author(s)
  芦野　隆、山本　雅之、沼澤　聡
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] Monocyte chemotactic protein-1による単球/マクロファージ浸潤、遊走におけるレドックス感受性転写因子Nrf2の役割2016
- Author(s)
  芦野　隆、山本　雅之、沼澤　聡
- Organizer
  第４３回日本毒性学会学術年会
- Place of Presentation
  ウインクあいち（名古屋）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] 血管傷害後内膜肥厚形成段階の血管平滑筋細胞アポトーシスにおけるKeap1/Nrf2システムの役割2015
- Author(s)
  芦野　隆、山本　雅之、沼澤　聡
- Organizer
  第４２回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（金沢）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15K19398
[Presentation] MCP-1によるマクロファージ遊走におけるNrf2の役割2014
- Author(s)
  渡邊円香、芦野　隆、山本雅之、沼澤　聡
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本大学（熊本）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 転写因子Nrf2のROS-ERK経路を介した血管傷害後のリモデリング調節機構2013
- Author(s)
  芦野　隆、山本雅之、吉田武美、沼澤　聡
- Organizer
  第４０回日本毒性学会学術年会
- Place of Presentation
  幕張メッセ国際会議場（千葉）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] Regulatory mechanism of neointimal formation after vascular injury by redox-sensitive transcription factor Nrf22013
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Coex（ソウル）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 血管内膜肥厚における酸化ストレス応答性転写因子Nrf2 の役割2012
- Author(s)
  小柴郁,芦野隆,山本雅之,吉田武美,沼澤聡
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] 血管平滑筋細胞遊走および血管リモデリングにおけるレドックス感受性転写因子Nrf2の役割2012
- Author(s)
  芦野隆,山本雅之,吉田武美,沼澤聡
- Organizer
  第39回日本毒性学会
- Place of Presentation
  仙台
- Year and Date
  2012-07-17
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] The redox-sensitive transcription factor Nrf2 regulates reactive oxygen species-dependent vascular smooth muscle cell migration and neointimal hyperplasia2012
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Organizer
  The 10th Korea-Japan Joint Symposium on Vascular Biology
- Place of Presentation
  徳島
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-12012
- Author(s)
  Ashino T, Sugiuchi J, Uehara J, Naito-Yamamoto Y, Kenmotsu S, Iwakura Y, Shioda S, Numazawa S, Yoshida T
- Organizer
  Society of Toxicology 2012 Annual Meeting
- Place of Presentation
  サンフランシスコ(アメリカ合衆国)
- Year and Date
  2012-03-12
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-12012
- Author(s)
  Ashino T, Sugiuchi J, Uehara J, Naito-Yamamoto Y, Kenmotsu S, Iwakura Y, Shioda S, Numazawa S, Yoshida T.
- Organizer
  SOT 2012 Annual Meeting
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] オーラノフィンによるヘムオキシゲナーゼ-1誘導を介したコカイン誘発肝障害防御作用2012
- Author(s)
  芦野隆,上原淳奈,杉内仁子,岩倉洋一郎,塩田清二,沼澤聡,吉田武美
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] Role of the redox-sensitive transcription factor Nrf2 in vascular smooth muscle cell migration and vascular remodeling2012
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] ニコチン脳室内投与によるマウス海馬における神経毒性発現に関連するmiRNAの変動2011
- Author(s)
  瀧憲二,丸茂瑠佳,芦野隆,田中佐知子,沼澤聡,吉田武美
- Organizer
  38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] 血管平滑筋細胞遊走と血管リモデリングにおける銅トランスポーターATP7Aの新規役割2011
- Author(s)
  芦野隆，Sudhahar Varadarajan，浦尾紀文，押川仁，Gin-Fu Chen，Ronald D. McKinney，深井真寿子，深井透
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] ニコチン脳室内投与によるマウス海馬における神経毒性発現に関連するmiRNAの変動2011
- Author(s)
  瀧憲二，丸茂瑠佳，芦野隆，田中佐知子，沼澤聡，吉田武美
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] Induction of CYP2B10 and CYP2A gene expressions by Nrf2 activators2007
- Author(s)
  H. Ohkubo, T. Ashino, M. Yamamoto, S. Numazawa, T. Yoshida
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  仙台
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19659030
[Presentation] 危険ドラッグ含有合成カンナビノイドによる薬物代謝酵素シトクロムP450 阻害作用
- Author(s)
  芦野　隆、伯川加菜絵、桜井彩華、伊藤有香、沼澤　聡
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  デザイン・クリエイティブセンター（神戸）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 血管平滑筋細胞遊走および血管リモデリングにおけるレドックス感受性転写因子Nrf2の役割
- Author(s)
  芦野　隆、山本雅之、吉田武美、沼澤　聡
- Organizer
  第３９回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23659068
[Presentation] 血管平滑筋細胞遊走および血管リモデリングにおけるレドックス感受性転写因子Nrf2の役割
- Author(s)
  芦野　隆、山本雅之、吉田武美、沼澤　聡
- Organizer
  第３９回日本毒性学会学術年会
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 血管内膜肥厚における酸化ストレス応答性転写因子Nrf2 の役割
- Author(s)
  小柴　郁、芦野　隆、山本雅之、吉田武美、沼澤　聡
- Organizer
  第５６回日本薬学会関東支部大会
- Place of Presentation
  昭和大学（東京）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] The redox-sensitive transcription factor Nrf2 regulates reactive oxygen species-dependent vascular smooth muscle cell migration and neointimal hyperplasia
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Organizer
  The 10th Korea-Japan Joint Symposium on Vascular Biology
- Place of Presentation
  あわぎんホール（徳島）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] Role of the redox-sensitive transcription factor Nrf2 in vascular smooth muscle cell migration and vascular remodeling
- Author(s)
  Ashino T, Yamamoto M, Yoshida T, Numazawa S
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  仙台国際センター（仙台）
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 合成カンナビノイドによる薬物代謝酵素シトクロムP450 1A阻害作用
- Author(s)
  芦野　隆、伊藤有香、伯川加菜絵、沼澤　聡
- Organizer
  第４１回日本毒性学会学術年会
- Place of Presentation
  神戸コンベンションセンター（神戸）
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] Novel role of Kelch-like ECH-associated protein 1/NF-E2-related factor 2 system in vascular smooth muscle cell apoptosis following vascular injury
- Author(s)
  Ashino T, Yamamoto M, Numazawa S
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  McCormick Place（シカゴ）
- Year and Date
  2014-11-15 – 2015-11-19
- Data Source
  KAKENHI-PROJECT-24790785
[Presentation] 血管内膜肥厚における酸化ストレス応答性転写因子Nrf2 の役割
- Author(s)
  小柴　郁、芦野　隆、山本雅之、吉田武美、沼澤　聡
- Organizer
  第５６回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659068

1. YOSHIDA Takemi (20138415)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
2. TANAKA Sachiko (00197419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. YOSHIDA Takemi (90006354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NUMAZAWA Satoshi (80180686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. 貝崎明日香 (70407443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安富祖文香 (30349039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 大滝博和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ashino Takashi 芦野 隆

ASHINO Takashi 芦野 隆

芦野 隆 アシノ タカシ

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Protective role of the oxidative stress response system against liver fibrogenesis in NAFLD/NASHPrincipal Investigator

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Role of reactive sulfur species in vascular redox regulation and inhibition of arteriosclerosisPrincipal Investigator

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Elucidation of a switching mechanism between production and extinction of reactive oxygen species on vascular remodeling after injuryPrincipal Investigator

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Mechanism of inhibition of vascular neointimal hyperplasia by oxidative stress responsive factor through functional reguration of vascular progenitor cellsPrincipal Investigator

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Role of the redox-sensitive transcription factor Nrf2 in vascular neointimal hyperplasiaPrincipal Investigator

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Mutual regulation of physiological gases by xenobiotics

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トキシコゲノミクスを基盤とした新規生体防御因子の探索

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Elucidation of defensive mechanism against xenobiotics in cytokine knock out and pathologic model mice

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Changes in cytochrome P450 and stress responsive proteins under oxidative stress

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[Journal Article] Toxicity manifestations and sex differences due to MARTA olanzapine2023

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[Journal Article] Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes2023

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[Journal Article] Downregulation of the gene expression of Cyp2c29 and Cyp3a11 by cecal ligation and puncture-induced sepsis is associated with interleukin-62023

Author(s)

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DOI

Data Source

[Journal Article] Interleukin-6 regulates the expression of hepatic canalicular efflux drug transporters after cecal ligation and puncture-induced sepsis: A comparison with lipopolysaccharide treatment2023

Author(s)

Journal Title

Ashino Takashi 芦野隆

ASHINO Takashi 芦野隆

芦野隆アシノタカシ