YOSHIDA Takemi 吉田武美

Researcher Number	20138415
Affiliation (based on the past Project Information) *help	2007 – 2008: Showa University, 薬学部, 教授 1992 – 2004: Sch.Pharm.Sci., Professor Showa University, 薬学部, 教授 1991: 昭和大学, 薬学部, 助教授 1986: Associate-Professor, School of Pharmaceutical Sciences, 薬学部毒物学, 助教授
Review Section/Research Field	Principal Investigator Environmental pharmacy / Biological pharmacy / Biological Sciences / Environmental pharmacy Except Principal Investigator Conservative dentistry / Biological pharmacy / Conservative dentistry
Keywords	Principal Investigator 分化誘導 / ブファリン / Na^+,K^+-ATPase / シトクロムP450 / アポトーシス / 酸化的ストレス / 白血病細胞 / U937細胞 / CAR / ヘムオキシゲナーゼ … More / メタロチオネイン / スチルベンオキシド / チトクロム P-450 / グルタチオン枯渇 / Metallothionein / oxidative stress / Cytochrome P450 / ヘムオキシゲナーゼ-1 / サイトカイン / MAPK / BCG / LPS / STAT / CYP2B / ブファジエノリド / 癌遺伝子 / 抗腫瘍作用 / MAPキナーゼ / THP-1細胞 / ウワバイン / 血管新生 / カゼインキナーゼ2 / トポイソメラーゼII / ERK / P38 / PKC / カルシウムイオン / 遺伝子発現 / シグナル伝達 / Nrf2 / ヘムオキシゲナーゼー1 / トキシコゲノミクス / 5-フルオロウラシル / カドミウム / 誘導型-酸化窒素合成酵素 / heme oxygenase-1 / NADPH:quinone oxidoreductase-1 / マウス / Cyp2b10 / グルタチオン / チトクロムP-450 / 酵素誘導 / 肝臓 / ヘムオキシゲナ-ゼ / チトクロムPー450 / Glutathione / Oxidative Stress / Heme Oxygenase / Cytochrome P-450 / Enzyme Induction / Stilbene Oxide / Liver / HepG2細胞 / フォロン / ジピリジル系化合物 / シトクロム P450 / ストレス応答 / 熱ショックタンパク質 / Glutathione depletion / Heme oxygenase / HepG2 cell / Phorone / Dipyridyls / TNFα / IL-6 / cytochromeP450 / heme oxygenese-1 / cytokine / リポポリサッカライド / HTLV-I Tgマウス / コカイン / ヘムオシゲナーゼ-1 / 酸化ストレス / 肝障害 / 関節リウマチ / 炎症性サイトカイン / オーラノフィン / Cytokine / Lipopolysaccharide / HTLV-I Tg mouse / Heine oxygenase-1 / Cocaine / Constitutive androstane receptor … More Except Principal Investigator contact dermatitis / HEMA / dentin primer / Maximization Test / TNFα / LPS / MAPK / BCG / CYP / 2-HEMA / GM / 学術用語 / 薬学用語 / 標準化 / Scientific terms / Terms in pharmaceutical sciences / Standerdization / delayed Allergy / Maximization test / デイティンプライマー / アレルギー反応 / GPMT / delayd Allergy / サイトカイン / ヘムオキシゲナーゼ / メタロチオネイン / 酸化ストレス / ノックアウトマウス / cytokine / heme oxygenase / metallothionein / ガスクロマトグラフィー / 遅延型 / 2-HEMA抗体 / 特異染色 / allergy / delayed / 変色 / 象牙質 / 原子吸光度 / Discoloration / Dentin / 肝小胞体 / スピンラベル / 酵素誘導 / チトクロームP-450 / 膜流動性 / 電子スピン共鳴 / フェノバルビタール / 生体膜 / rat liver microsomes / spin-label / ESR / biomembrane / phenobarbirtal / cytochrome P-450 Less

トキシコゲノミクスを基盤とした新規生体防御因子の探索Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
Elucidation of defensive mechanism against xenobiotics in cytokine knock out and pathologic model micePrincipal Investigator
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa University
Development of the protein caused by discoloration teeth resolution enzyme.
- Principal Investigator
  
  MANABE Atsufumi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University
Na^+,K^+-ATPase阻害剤による抗癌作用機構解明とその臨床応用Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
The influence of the dental monomer to the dentin and a oral mucose
- Principal Investigator
  
  MANABE Atsufumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University
Changes in cytochrome P450 and stress responsive proteins under oxidative stressPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa university
Study on possible role of cytokines in response to oxidative stress by using cytokine knock out mice
- Principal Investigator
  
  OGURO Takiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa university
Na,K-ATPase阻害と癌細胞分化やアポトーシス誘導への情報伝達機構解明Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
ブファリンの標的Na,K-ATPase阻害と分化や細胞死の誘導機構解明と抗癌剤開発Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
Na^+,K^+-ATPaseを標的とするブファリンの分化誘導機構解明と抗癌剤としての開発Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Showa University
The investigation of side dffects to the fingertips caused by dental adhesive monomers.
- Principal Investigator
  
  MANABE Atsufumi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University
生薬センソ成分ブファリンの癌細胞分化誘導機構解明と新たな制癌剤としての開発研究Principal Investigator
- Principal Investigator
  
  吉田武美
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Showa University
Multiple Oxidative Stress Responses for Hepatic Glutathione Depletion Evoked by Drugs and chemicalsPrincipal Investigator
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Investigation for the Standardization of Terms on Pharmaceutical Sciences
- Principal Investigator
  
  SUGA Tetsuya
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Institution
  Tokyo College of Pharmacy
Specific Induction of Enzymes in the Liver Accompanying by Oxidative Stress after Glutathione depletion and Its Significance.Principal Investigator
- Principal Investigator
  
  YOSHIDA Takemi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
Studies on the relation between the biological function and the dynamic properties of rat liver plasma and microsomal membranes
- Principal Investigator
  
  UTSUMI Hideo
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University

All 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages2008
- Author(s)
  T. Ashino, R. Yamanaka, M. Yamamoto, H. Shimokawa, K. Sekikawa, Y. Iwakura, S. Shioda, S. Numazawa, T. Yoshida
- Journal Title
  
  Molecular Immunology 45
  
  Pages: 2106-2115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659030
[Journal Article] Redox reguration of a transcriptional repressor Bach12005
- Author(s)
  Ishikawa M, Numazawa S, Yoshida T.
- Journal Title
  
  Free Radical Biology and Medicine (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Involvement of interleukin-G and tumor necrosis factor a in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T
- Journal Title
  
  Drug Metabolism and Disposition 32(7)
  
  Pages: 707-714
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
- Journal Title
  
  Drug Metabolism and Disposition Vol.32,No.7
  
  Pages: 707-714
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Nrf2-dependent gene expressions: A molecular toxicological aspect2004
- Author(s)
  T Yoshida, S Numazawa
- Journal Title
  
  The journal of toxicological sciences 29
- NAID
  110001812860
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15592030
[Journal Article] Involvement of interleukin-6 and tumor necrosis factor α in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver2004
- Author(s)
  Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T.
- Journal Title
  
  Drug Metabolism and Disposition Vol.32, No.7
  
  Pages: 707-714
- Data Source
  KAKENHI-PROJECT-15390041
[Journal Article] Redox reguratiorn of a transcriptional repressor Bach1
- Author(s)
  Ishikawa M, Numazawa S, Yoshida T
- Journal Title
  
  Free Radical Biology and Medicine (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390041
[Presentation] Induction of CYP2B10 and CYP2A gene expressions by Nrf2 activators2007
- Author(s)
  H. Ohkubo, T. Ashino, M. Yamamoto, S. Numazawa, T. Yoshida
- Organizer
  8th International ISSX Meeting
- Place of Presentation
  仙台
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19659030

1. NUMAZAWA Satoshi (80180686)

# of Collaborated Projects: 8 results

# of Collaborated Products: 5 results
2. ASHINO Takashi (00338534)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. OGURO Takiko (10185572)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MANABE Atsufumi (40199906)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TANAKA Sachiko (00197419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NAKAYAMA Sadao (00054007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ITOH Kazuo (30129811)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUGA Tetsuya (20057318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. RIKIHISA Tadaaki (70012622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMANOUCHI Sakae (20059249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MISAWA Miwa (20061294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGAI Tuneji (40061270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMIOKA Kiyoshi (50114575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAMEJIMA Keijiro (00072413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IIJIMA Masafumi (20010449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SASA Ryuzi (20014201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAEDA Masako (00053869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OGUCHI Katsuzi (50129821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. UTSUMI Hideo (20101694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山元俊憲 (30112741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 中谷一泰 (40053855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 黒岩幸雄 (20053796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 黒沢雅広 (10297020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 渡部正彦 (90301788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 貝崎明日香 (70407443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 佐用博照 (70068302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 三川潮 (60012613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 首藤紘一 (50012612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 北澤式文 (50026887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 辻章夫 (80053784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 寺尾允男 (60012605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 粟津荘司 (60012621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 野村靖幸 (00034041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 狐塚寛 (60092748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 濱田昭 (50053781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 安富祖文香 (30349039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 三輪亮寿

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOSHIDA Takemi 吉田 武美

Research Projects

Research Products

Co-Researchers

トキシコゲノミクスを基盤とした新規生体防御因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of defensive mechanism against xenobiotics in cytokine knock out and pathologic model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the protein caused by discoloration teeth resolution enzyme.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Na^+,K^+-ATPase阻害剤による抗癌作用機構解明とその臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The influence of the dental monomer to the dentin and a oral mucose

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Changes in cytochrome P450 and stress responsive proteins under oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on possible role of cytokines in response to oxidative stress by using cytokine knock out mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Na,K-ATPase阻害と癌細胞分化やアポトーシス誘導への情報伝達機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ブファリンの標的Na,K-ATPase阻害と分化や細胞死の誘導機構解明と抗癌剤開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Na^+,K^+-ATPaseを標的とするブファリンの分化誘導機構解明と抗癌剤としての開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

The investigation of side dffects to the fingertips caused by dental adhesive monomers.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生薬センソ成分ブファリンの癌細胞分化誘導機構解明と新たな制癌剤としての開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Multiple Oxidative Stress Responses for Hepatic Glutathione Depletion Evoked by Drugs and chemicalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the Standardization of Terms on Pharmaceutical Sciences

Principal Investigator

YOSHIDA Takemi 吉田武美