SAMEJIMA Keijiro 鮫島啓二郎

… Alternative Names

鮫島敬二郎サメジマケイジロウ

鮫島啓二郎サメジマケイジロウ

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Researcher Number	00072413
Other IDs
Affiliation (Current)	2022: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員
Affiliation (based on the past Project Information) *help	2001 – 2004: 城西大学, 薬学部, 教授 1995 – 1997: 城西大学, 薬学部, 教授 1987 – 1993: 城西大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Physical pharmacy
Keywords	Principal Investigator スペルミジン合成酵素 / 活性部位構造 / ポリアミンアナログ / 脱炭酸化S-アデノシルメチオニン / スペルミン合成酵素 / Spermidine synthase / MALDI-TOF-MS / spermidine synthase / 阻害剤 / IS-MS … More / PCNA / trans-4-methylcyclohexylamine / 5-カルボキシスペルミン / HTC細胞 / ハイプシン / アポトーシス / スペルミジン / ジアステレオマーの分離 / 細胞の増殖 / 標識誘導体 / 標識透導体 / 5-Carboxyspermine / HTC cells / Polyamine analogues / Hypusine / Apoptosis / spermidine / DEcarboxylated S-adnosylmethionine / アミノ酸配列 / SH試薬 / 二機能性試薬 / 二機能性試験薬 / amino acid sequence / active site structure / SH-reagent / two functional reagent / decarboxylated S-adenosylmethionine / ポリアミン / 再生肝 / 安定同位体 / トランス-4-メチルシクロヘキシルアミン / マススペクトロメトリー / 体内動態 / 癌 / イオンスプレーイオン化 / 質量分析 / トレーサー実験 / ホモロジーモデリング / ジアセチルスペルミン / polyamine / inhibitor / regenerating liver / stable isotope / 基質特異性 / アフィニティ吸着体 / ポリアミン親和性蛋白 / 酵素の精製 / ポリアミン結合部位 / アミノプロピル基転移反応 / アミノプロピルトランスフェラ-ゼ / スペルミジン結合部位 / 拮抗阻害剤 / アフィニティ-吸着体 / アミノプロピルトランスフェラーゼ / 阻害剤のデザイン / Spermine synthase / Active site structure / Inhibitor / Substrate specificity / Affinity adsorbent / Polyamine binding protein / Purification of enzyme … More Except Principal Investigator ポリアミン / ポリアミン合成阻害剤 / 制がん剤 / オルニチン脱炭酸酵素 / スペルミジン / スペルミン / Sーアデノシルメチオニン脱炭酸酵素 / S-アデノシルメチオニン脱炭酸酵素 / 転移抑制 / 学術用語 / 薬学用語 / 標準化 / Scientific terms / Terms in pharmaceutical sciences / Standerdization Less

Development of methodology to study in vivo changes in polyamines levels and its applicationPrincipal Investigator
- Principal Investigator
  
  SAMEJIMA Keijiro
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Studies on steric structure of substrate binding site of rat spermidine synthasePrincipal Investigator
- Principal Investigator
  
  SAMEJIMA Keijiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
Investigation for the Standardization of Terms on Pharmaceutical Sciences
- Principal Investigator
  
  SUGA Tetsuya
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Institution
  Tokyo College of Pharmacy
Development of methodology for investigation of polyamine-macromolecule interaction in living cellsPrincipal Investigator
- Principal Investigator
  
  SAMEJIMA Keijiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  JOSAI UNIVERSITY
Study on Binding Site of Polyamine Binding ProteinPrincipal Investigator
- Principal Investigator
  
  SAMEJIMA Keijiro
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Josai University
ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究
- Principal Investigator
  
  林伸一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jikei University School of Medicine
ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究
- Principal Investigator
  
  林伸一
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jikei University School of Medicine

All 2005 2004 2003 2002

All Journal Article

[Journal Article] Control of Spermidine and Spermine Levels in Rat Tissues by trans-4-Methylcyclohexylamine, a Spermidine-Synthase Inhibitor.2005
- Author(s)
  M.Kobayashi, T.Watanabe, Y.J.Xu, M.Tatemori, H.Goda, M.Niitsu, A.Shirahata, K.Samejima
- Journal Title
  
  Biol.Pharm.Bull. 28(4)
  
  Pages: 569-573
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261
[Journal Article] Mammalian Spermidine Synthase-Identification of Cysteine Residues and Investigation of the Putrescine Binding Site-2004
- Author(s)
  H.Goda, T.Watanabe, N.Takeda, K.Kobayashi, M.Wada, H.Hosoda, A.Shirahata, K.Samejima
- Journal Title
  
  Biol.Pharm.Bull. 27(9)
  
  Pages: 1327-1332
- NAID
  110003608971
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261
[Journal Article] Fate of Orally Administered ^<15>N-Labeled Polyamines in Rats Bearing Solid Tumors.2003
- Author(s)
  M.Kobayashi, Y.J.Xu, K.Samejima, H.Goda, M.Niitsu, M.Takahashi, Y.Hashimoto
- Journal Title
  
  Biol.Pharm.Bull. 26(3)
  
  Pages: 285-288
- NAID
  110004639235
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261
[Journal Article] Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases.2003
- Author(s)
  H.Dejima, M.Kobayashi, H.Takasaki, N.Takeda, A.Shirahata, K.Samejima
- Journal Title
  
  Biol.Pharm.Bull. 26(7)
  
  Pages: 1005-1008
- NAID
  110004639236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261
[Journal Article] Mass Spectrometric Separation and Determination of N^1,N^<12>-Diacetylspermine in Cancer Patients.2002
- Author(s)
  M.Kobayashi, K.Samejima, K.Hiramatsu, M.Kawakita
- Journal Title
  
  Biol.Pharm.Bull. 25(3)
  
  Pages: 372-374
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261
[Journal Article] Simultaneous Determination of Endogenous and Orally Administered ^<15>N-labeled polyamines in rat organs.2002
- Author(s)
  Y.J.Xu, T.Kara, K.Samejima, H.Sasaki, M.Kobayashi, A.Takahashi, M.Niitsu
- Journal Title
  
  Anal.Biochem. 301(2)
  
  Pages: 255-260
- NAID
  110004622953
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13672261

1. SHIRAHATA Akira (50150107)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. NIITSU Masaru (00077976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 林伸一 (50028297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 五十嵐一衛 (60089597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 森沢成司 (90046813)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 大島泰郎 (60167301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUGA Tetsuya (20057318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. RIKIHISA Tadaaki (70012622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMANOUCHI Sakae (20059249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOSHIDA Takemi (20138415)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MISAWA Miwa (20061294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGAI Tuneji (40061270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMIOKA Kiyoshi (50114575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. GODA Hitomi (30170690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 永津俊治 (40064802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鈴木不二男 (40028717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐用博照 (70068302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三川潮 (60012613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 首藤紘一 (50012612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 北澤式文 (50026887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 辻章夫 (80053784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 寺尾允男 (60012605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 粟津荘司 (60012621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 野村靖幸 (00034041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 狐塚寛 (60092748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 濱田昭 (50053781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 三輪亮寿

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAMEJIMA Keijiro 鮫島 啓二郎

鮫島 敬二郎 サメジマ ケイジロウ

鮫島 啓二郎 サメジマ ケイジロウ

Research Projects

Research Products

Co-Researchers

Development of methodology to study in vivo changes in polyamines levels and its applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on steric structure of substrate binding site of rat spermidine synthasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the Standardization of Terms on Pharmaceutical Sciences

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Development of methodology for investigation of polyamine-macromolecule interaction in living cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Binding Site of Polyamine Binding ProteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Journal Article] Control of Spermidine and Spermine Levels in Rat Tissues by trans-4-Methylcyclohexylamine, a Spermidine-Synthase Inhibitor.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mammalian Spermidine Synthase-Identification of Cysteine Residues and Investigation of the Putrescine Binding Site-2004

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Fate of Orally Administered ^<15>N-Labeled Polyamines in Rats Bearing Solid Tumors.2003

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases.2003

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Mass Spectrometric Separation and Determination of N^1,N^<12>-Diacetylspermine in Cancer Patients.2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] Simultaneous Determination of Endogenous and Orally Administered ^<15>N-labeled polyamines in rat organs.2002

Author(s)

Journal Title

NAID

Description

Data Source

SAMEJIMA Keijiro 鮫島啓二郎

鮫島敬二郎サメジマケイジロウ

鮫島啓二郎サメジマケイジロウ