Igarashi Kazuei 五十嵐一衛

… Alternative Names

五十嵐一衛イガラシカズエイ

IGARASHI Kazuei 五十嵐一衛

五十嵐一衞イガラシカズエイ

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Researcher Number	60089597
Other IDs
Affiliation (Current)	2023: 株式会社アミンファーマ研究所, その他部局等, 代表取締役
Affiliation (based on the past Project Information) *help	2021: 株式会社アミンファーマ研究所, その他部局等, 代表取締役 2017: 千葉大学, 大学院薬学研究院, 名誉教授研究 2013 – 2014: 株式会社アミンファーマ研究所, その他部局等, 代表取締役社長 2012: 株式会社アミンファーマ研究所, その他部局等, その他 2011: 株式会社アミンファーマ研究所, 代表取締役社長 … More 2007 – 2009: Chiba University, 名誉教授 2001 – 2005: 千葉大学, 大学院・薬学研究院, 教授 1990 – 2000: 千葉大学, 薬学部, 教授 1994: 千葉大学, ・薬学部, 教授 1987 – 1988: 千葉大学, 薬学部, 教授 1987: 千葉大学, 葉学部, 教授 1986: 千葉大, 生物活性研究所, 教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Biological pharmacy / 医薬分子機能学 / Structural biochemistry Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Drug development chemistry / Living organism molecular science
Keywords	Principal Investigator ポリアミン / スペルミン / Polyamine / スペルミジン / Spermine / NMDA受容体 / NMDA receptor / Spermidine / アンチザイム / プトレスシン … More / RF2 / eIF4G / ポリアミン輸送蛋白質 / 細胞増殖 / 蛋白質合成 / モジュロン / eIF5A / SD配列 / 蛋白質合成開始 / ポリアミン輸送 / チャネルブロッカー / Channel blocker / アンタゴニスト / Putrescine / σ^<38> / eIF4E / フレームシフト / デオキシスパーガリン / Modulon / R-domain / イフェンプロジル / σ^<28> / ATP / Aminoglycoside / アミノグリコシド / Mg^<2+> / Site-directed mutagenesis / 部位突然変異 / Antagonist / ポリアミン結合部位 / 輸送 / オルニチン脱炭酸酵素 / 脳梗塞 / アクロレイン / バイオテクノロジー / 脳・神経 / 生理活性 / 生体分子 / Fis / ポリアミンモジュロン / ハイプシン / IRES / Cap / OppA / 結合部位 / 抗がん効果 / ビスエチルポリアミン誘導体 / cell proliferation / Thymidine kinase / polyamine induced (PI) protein / polyamine transport protein / 膜透過酵素 / ポリアミン輸送蛋白 / 蛋白合成促進 / Stroke / Acrolein / Anthraquinone spermidine / AQポリアミン / チトクロムc / アントラキノンスペルミジン / Frameshift / Anthraquinon derivative / Ototoxicity / Regulatory domain / アントラキノン誘導体 / 難聴 / 調節領域 / Vacuolar membrane / Polyamine transport protein / Adenylate cyclase / 液胞膜 / アデニレートシクラーゼ / SD sequence / Polyamine transport / protein kinase / Binding site / 活性調節 / 部位突然異変 / Agonist / ビスエチルポリアミン / ポリアンミン / チャンネルブロッカー / アゴニスト / Polyamine binding site / Polyamine transprt system / プロテインキナーゼ / ATPase / Cell differentiation / Cell proliferation / Transport / Protein synthesis / 細胞分化 / 5'-Untranslated region / Ornithine decarboxylase / Antizyme / ヘリカーゼ / eIF-4E / 5'-untranslated region / 5′-untranslated region / transport gene / polyamine transport / spermidine / putrescine / polyamine / クロ-ニング / ポリアミン輸送タンパク質 / 遺伝子発現調節 / クローニング / 3-HPMA / マクロファージの泡沫化 / GAPDH / Aβ40/42 / CRP / IL-6 / アルツハイマー病 / 細胞障害 / グルタチオン / 核酸 / FecI / 生存率 / Fecl / Cra / FecI (σ^<18>) / FecI(σ^<18>) / ODC mRNA / 開始コドンUUG / Cya mRNA / 5'-UTR / 開始コドンAUG / OppA mRNA / s'-UTR / 開始コンドAUG / OppAmRNA / スキャニング / RNAヘリカーゼ / RMF / チャネルブロック / 活性促進 / site-directed mutagenesis … More Except Principal Investigator ポリアミン / NMDA受容体 / アクロレイン / スペルミン / スペルミジン / オルニチン脱炭酸酵素 / 制がん剤 / ポリアミン合成阻害剤 / 構造活性相関 / 脳機能改善薬 / 老化防止薬 / 遺伝子発現制御 / アクロレイン除去剤 / ヒストン脱メチル化酵素 / ヒストン修飾 / 翻訳 / 脳虚血 / MMP9 / ヘパリン / ヒアルロニダーゼ / ヘパラナーゼ / 酸化ストレス / 脳梗塞 / コンドロイチン硫酸 / ヘパラン硫酸 / 糖衣 / pharmacy education / drug safety / mechanism of drug action / evaluation / pharmaceutical / synthetic drug / natural resources / new drug development / 安全性 / 体内動態 / 薬理学的研究 / 天然薬用資源 / 薬学教育 / 薬物の安全性 / 薬効発現機構 / 薬効評価 / 合成医薬品 / 天然資源 / 新薬開発 / 転移抑制 / S-アデノシルメチオニン脱炭酸酵素 / Sーアデノシルメチオニン脱炭酸酵素 / 能機能改善薬 / チャネルブロッカー / インドール / 認知症 / 脳機能 / オピオイド / リコポジウム / 全合成 / 不斉全合成 / 成分探索 / アルカロイド / 鎮痛薬 / 基質結合蛋白質 / チャネルブロック / 活性促進 / site-directed mutagenesis / 結合部位 Less

細胞増殖因子ポリアミンの生理機能解析とその毒性代謝物アクロレインの除去剤の探索
- Principal Investigator
  
  柏木敬子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Chiba Institute of Science
Degradation of glycosaminoglycans in cerebral infarction
- Principal Investigator
  
  Higashi Kyohei
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Elucidation of molecular mechanism of cellular toxicity of acrolein and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Amine Pharma Research Institute Co., Ltd.
新規NMDA受容体チャネルブロッカー探索による脳機能改善薬の創製
- Principal Investigator
  
  高山廣光
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Chiba University
Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.
- Principal Investigator
  
  TAKAYAMA Hiromitsu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Chiba University
Elucidation of function of polyamines and regulation of their contents in cellsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
ポリアミンモジュロンによる細胞増殖と生存率の調節Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Regulation of cell growth and brain function by polyaminesPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
ポリアミンモジュロンによる細胞増殖と生存率の調節Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ポリアミンレギュロンによる細胞増殖と生存率の調節Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ポリアミンによるRNA機能のモジュレーションPrincipal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Modulation of cellular functions by polyamines through polyamine interaction with RNA and proteinsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
蛋白質合成開始因子eIF4E,4G及び5Aによる遺伝子発現調節Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
蛋白質合成素過程の解析とポリアミンの役割Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
蛋白質合成開始因子eIF4E、4G及び5Aによる遺伝子発現調節Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
蛋白質合成素過程の解析とポリアミンの役割Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
Polyamines as biomodulators - regulation of their contents and their physiological functionsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
Polyamines as biomodulators - regulation of their contents and their physiological functionsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
ポリアミン代謝拮抗に基づく抗がん剤の分子設計Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
蛋白質合成開始素過程の解析とポリアミンの役割Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Chiba University
ポリアミン輸送系とNMDA受容体の構造・機能協関
- Principal Investigator
  
  柏木敬子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
シナプス可塑性に果たすポリアミンの役割Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
ポリアミンによる蛋白質合成開始調節機序Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Regulation of glutamate receptors by polyaminesPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
Regulation of polyamine contents in cells and their physiological functionsPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
ビスエチルポリアミン誘導体の抗がん効果Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Regulation of NMDA receptor by polyamine and its derivativesPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Regulation of polyamine contents in cells and their effects on protein synthesisPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
Search for polyamine agonists and antagonists acting on NMDA receptor.Principal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
ビスエチルポリアミン誘導体の抗がん効果Principal Investigator
- Principal Investigator
  
  五十嵐一衛
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Chiba University
Role of polyamines on cell proliferation and differentiationPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
Physiological functions of polyamines and its transportPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Chiba University
Cloning of the genes for polyamine transport proteins and regulation of its expressionPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University
General Studies on the Development of Novel Materials and their Evaluation as new Drugs
- Principal Investigator
  
  SUZUKI Tokuji
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University
ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究
- Principal Investigator
  
  林伸一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jikei University School of Medicine
ポリアミンの特異的役割を利用した制がん剤の開発に関する基礎的ならびに臨床的研究
- Principal Investigator
  
  林伸一
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jikei University School of Medicine
Molecular mechanism of polyamine effect on cell proliferationPrincipal Investigator
- Principal Investigator
  
  IGARASHI Kazuei
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University

All 2021 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

[Journal Article] Functional roles of polyamines and their metabolite acrolein in eukaryotic cells2021
- Author(s)
  Igarashi Kazuei、Kashiwagi Keiko
- Journal Title
  
  Amino Acids
  
  Volume: 53 Issue: 10 Pages: 1473-1492
- DOI
  10.1007/s00726-021-03073-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714
[Journal Article] Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines2021
- Author(s)
  Sakamoto A, Terui Y, Uemura T, Igarashi K, Kashiwagi K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22(3) Issue: 3 Pages: 1307-1307
- DOI
  10.3390/ijms22031307
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16357, KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Reduction of Spermidine Content Resulting from Inactivation of Two Arginine Decarboxylases Increases Biofilm Formation in Synechocystis sp. PCC 68032018
- Author(s)
  Kota Kera, Tatsuya Nagayama, Kei Nanatani, Chika Saeki-Yamoto, Akira Tominaga, Satoshi Souma, Nozomi Miura, Kota Takeda, Syunsuke Kayamori, Eiji Ando, Kyohei Higashi, Kazuei Igarashi and Nobuyuki Uozumi
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 9 Issue: 9 Pages: 664-706
- DOI
  10.1128/jb.00664-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18670, KAKENHI-PROJECT-15K08068, KAKENHI-PROJECT-18K06652, KAKENHI-PROJECT-16H04906, KAKENHI-PLANNED-16H06558
[Journal Article] Determination of 3-hydroxypropylmercapturic acid in urine by three column-switching high-performance liquid chromatography with electrochemical detection using a diamond electrode.2017
- Author(s)
  Higashi K, Shibasaki M, Kuni K, Uemura T, Waragai M, Uemura K, Igarashi K, Toida T.
- Journal Title
  
  J. Chromatogr. A
  
  Volume: 1517 Pages: 79-85
- DOI
  10.1016/j.chroma.2017.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08068
[Journal Article] Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.2016
- Author(s)
  Imamura M, Higashi K, Yamaguchi K, Asakura K, Furihata T, Terui Y, Satake T, Maegawa J, Yasumura K, Ibuki A, Akase T, Nishimura K, Kashiwagi K, Linhardt RJ, Igarashi K, Toida T
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 33549-33549
- DOI
  10.1038/srep33549
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07921, KAKENHI-PROJECT-15K08068, KAKENHI-PROJECT-16K08244
[Journal Article] Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase2016
- Author(s)
  S. Sugiyama, S. Ishikawa, H. Tomitori, M. Niiyama, M. Hirose, Y. Miyazaki, K. Higashi, M. Murata, H. Adachi, K. Takano, S. Murakami, T. Inoue, Y. Mori, K. Kashiwagi, K. Igarashi, H. Matsumura
- Journal Title
  
  Int. J. Biochem. Cell Biol.
  
  Volume: 76 Pages: 87-97
- DOI
  10.1016/j.biocel.2016.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00783, KAKENHI-PROJECT-25282230, KAKENHI-PROJECT-15K08068, KAKENHI-PROJECT-16K07270
[Journal Article] Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein2016
- Author(s)
  Higashi K, Igarashi K, Toida T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 6 Pages: 915-919
- DOI
  10.1248/bpb.b15-01022
- NAID
  130005155127
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Data Source
  KAKENHI-PROJECT-15K08068
[Journal Article] Association between components of exudates and periwound moisture-associated dermatitis in breast cancer patients with malignant fungating wounds.2016
- Author(s)
  Tamai N, Akase T, Minematsu T, Higashi K, Toida T, Igarashi K, Sanada H.
- Journal Title
  
  Biol. Res. Nurs.
  
  Volume: 18 Issue: 2 Pages: 199-206
- DOI
  10.1177/1099800415594452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08068, KAKENHI-PROJECT-15H05066
[Journal Article] A novel putrescine exporter SapBCDF of Escherichia coli.2016
- Author(s)
  Y. Sugiyama, A. Nakamura, M. Matsumoto, A. Kanbe, H. Suzuki, M. Sakanaka, K. Higashi, K. Igarashi, T. Katayama, and S. Kurihara.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 51 Pages: 26343-26351
- DOI
  10.1074/jbc.m116.762450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07357, KAKENHI-PROJECT-15K08068
[Journal Article] Spermidine and Ca2+, but not Na+, can permeate NMDA receptors consisting of GluN1 and GluN2A or GluN2B in the presence of Mg2+.2015
- Author(s)
  Hirose T, Saiki R, Yoshizawa Y, Imamura M, Higashi K, Ishii I, Toida T, Williams K, Kashiwagi K, Igarashi K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 463 Issue: 4 Pages: 1190-1195
- DOI
  10.1016/j.bbrc.2015.06.081
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Journal Article] Polyamines and their metabolites as diagnostic markers of human diseases.2013
- Author(s)
  Park, M. H. and Igarashi, K.
- Journal Title
  
  Biomol. Ther.
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.4062/biomolther.2012.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390038
[Journal Article] Protein-conjugated acrolein as a biochemical marker of brain infarction2011
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Mol.Nutr.Food Res.
  
  Volume: 55(Review article) Issue: 9 Pages: 1332-1341
- DOI
  10.1002/mnfr.201100068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390038, KAKENHI-PROJECT-23590088
[Journal Article] Identification and assays of polyamine transport systems in Escherichia coli and Saccharomyces cerevisiae2011
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Methods Mol.Biol.
  
  Volume: 720(Review article) Pages: 295-308
- DOI
  10.1007/978-1-61779-034-8_18
- ISBN
  9781617790331, 9781617790348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390038, KAKENHI-PROJECT-23590088
[Journal Article] Characterization of genes for polyamine modulon2011
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Methods Mol.Biol.
  
  Volume: 720(Review article) Pages: 51-65
- DOI
  10.1007/978-1-61779-034-8_3
- ISBN
  9781617790331, 9781617790348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390038, KAKENHI-PROJECT-23590088
[Journal Article] Use of polyamine metabolites as markers for stroke and renal failure2011
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Methods Mol.Biol.
  
  Volume: 720(Review article) Pages: 395-408
- DOI
  10.1007/978-1-61779-034-8_25
- ISBN
  9781617790331, 9781617790348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390038, KAKENHI-PROJECT-23590088
[Journal Article] Identification of acrolein-conjugated protein in plasma of patients with brain infarction2010
- Author(s)
  Yoshida, M., Higashi, K., Jin, L., Machi, Y., Suzuki, T., Masuda, A., Dohmae, N., Suganami, A., Tamura, Y., Nishimura, K., Toida, T., Tomitori, H., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 391
  
  Pages: 1234-1239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Modulation of cellular function by polyamines2010
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 42
  
  Pages: 39-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Modulation of cellular function by polyamines.(Review article)2010
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 42
  
  Pages: 39-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Intense correlation between protein-conjugated acrolein and primary Sjogren's syndrome2010
- Author(s)
  Higashi, K., Yoshida, M., Igarashi, A., Ito, K., Wada, Y., Murakami, S., Kobayashi, D., Nakano, M., Sohda, M., Nakajima, T., Narita, I., Toida, T., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Clin.Chim.Acta 41
  
  Pages: 359-363
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Characteristics of cellular polyamine transport in prokaryotes and eukaryotes.(Review article)2010
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Plant Physiol.Biochem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Polyamine binds to regulatory domain of NMDA receptor2009
- Author(s)
  Kazuei Igarashi
- Journal Title
  
  Seitai no Kagaku 60
  
  Pages: 360-361
- Data Source
  KAKENHI-PROJECT-20659016
[Journal Article] Intense correlation between brain infarction and protein-conjugated acrolein2009
- Author(s)
  Saiki, R., Nishimura, K., Ishii, I., Omura, T., Okuyama, S., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Stroke 40
  
  Pages: 3356-3361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Polyamine-modulon in yeast―stimulation of COX4 synthesis by spermidine at the level of translation2009
- Author(s)
  Uemura, T., Higashi, K., Takigawa, M., Toida, T., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 41
  
  Pages: 2538-2545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Identification of proteins whose synthesis is preferentially enhanced by polyamines at the level of translation in mammalian cells2009
- Author(s)
  Nishimura, K., Okudaira, H., Ochiai, E., Higashi, K., Kaneko, M., Ishii, I., Nishimura, T., Dohmae, N., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Int.J.Biochem.Cell Biol. 41
  
  Pages: 2251-2261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Acrolein, IL-6 and CRP as markers of silent brain infarction2009
- Author(s)
  Yoshida, M., Tomitori, H., Machi, Y., Katagiri, D., Ueda, S., Horiguchi, K., Kobayashi, E., Saeki, N., Nishimura, K., Ishii, I., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Atherosclerosis 203
  
  Pages: 557-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Acrolein toxicity : comparison with reactive oxygen species2009
- Author(s)
  Yoshida, M., Tomitori, H., Machi, Y., Hagihara, M., Higashi, K., Goda, H., Ohya, T., Niitsu, M., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 378
  
  Pages: 313-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in Escherichia coli under heat shock conditions2009
- Author(s)
  Terui, Y., Higashi, K., Tabei, Y., Tomitori, H., Yamamoto, K., Ishihama, A., Igarashi, K., Kashiwagi, K.
- Journal Title
  
  J.Bacteriol. 191
  
  Pages: 5348-5357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Selective structural change by spermidine of the bulged-out region of double-stranded RNA and its effect on RNA function2008
- Author(s)
  Higashi, K., Terui, Y., Suganami, A., Tamura, Y., Nishimura, K., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 32989-32994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Selective structural change of bulged-out region of double-stranded RNA containing bulged nucleotides by spermidine2008
- Author(s)
  Higashi, K., Terui, Y., Inomata, E., Katagiri, D., Nomura, Y., Someya, T., Nishimura, K., Kashiwagi, K., Kawai, G., Igarashi, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 370
  
  Pages: 572-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Identification of a spermidine excretion protein complex (MdtJI) in Escherichia coli2008
- Author(s)
  Higashi, K., Ishigure, H., Demizu, R., Uemura, T., Nishino, K., Yamaguchi, A., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Bacteriol. 190
  
  Pages: 872-878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine2008
- Author(s)
  Jin, L., Miyazaki, M., Mizuno, S., Takigawa, M., Hirose, T., Nishimura, K., Toida, T., Williams, K., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 327
  
  Pages: 68-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-Daspartate receptor2008
- Author(s)
  Han, X., Tomitori, H., Mizuno, S., Higashi, K., Full, C., Fukiwake, T., Terui, Y., Leewanich, P., Nishimura, K., Toida, T., Williams, K., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Neurochem. 107
  
  Pages: 1566-1577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Minor contribution of an internal ribosome entry site in the 5'-UTR of ornithine decarboxylase mRNA on its translation2007
- Author(s)
  Nishimura, K., Sakuma, A., Yamashita, T., Hirokawa, G., Imataka, H., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 364
  
  Pages: 124-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Comparative studies of anthraquinone-and anthracenetetraamines as blockers of N-methyl-D-aspartate receptors2007
- Author(s)
  Jin, L., Sugiyama, H., Takigawa, M., Katagiri, D., Tomitori, H., Nishimura, K., Kaur, N., Phanstiel IV, O., Kitajima, M., Takayama, H., Okawara, T., Williams, K., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 320
  
  Pages: 47-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Enhancement of the synthesis of RpoN, Cra and H-NS by polyamines at the level of translation in Escherichia coli cultured with glucose and glutamate2007
- Author(s)
  Terui, Y., Higashi, K., Taniguchi, S., Shigemasa, A., Nishimura, K., Yamamoto, K., Kashiwagi, K., Ishihama, A., Igarashi, K.
- Journal Title
  
  J.Bacteriol. 189
  
  Pages: 2359-2368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Anthraquinone polyamines : novel channel blockers of N-methyl-D-aspartate receptors2007
- Author(s)
  Kashiwagi, K., Williams, K., Igarashi, K.
- Journal Title
  
  Amino Acids 33
  
  Pages: 299-304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Design, Synthesis and Biological Evaluation of Tricyclic Heterocycle-Tetraamine Conjugates as Potent NMDA Channel Blockers2007
- Author(s)
  H. Takayama, Y. Yaegashi, M. Kitajima, X. Han, K. Nishimura, S. Okuyama, K. Igarashi
- Journal Title
  
  Bioorg.Med.Chem.Lett. 17
  
  Pages: 4729-4732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19310137
[Journal Article] Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae2007
- Author(s)
  Uemura, T., Kashiwagi, K., Igarashi, K.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 7733-7741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Journal Article] Characteristics of cellular polyamine transport in prokaryotes and eukaryotes
- Author(s)
  Igarashi, K., Kashiwagi, K.
- Journal Title
  
  Plant Physiol.Biochem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390016
[Patent] 3-HPMAを指標とした脳卒中及び/又は脳梗塞の判定方法2012
- Inventor(s)
  五十嵐一衛、柏木敬子、吉田円、溝井睦美、斎木遼太郎
- Industrial Property Rights Holder
  株式会社アミンファーマ研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2012-06-11
- Data Source
  KAKENHI-PROJECT-23390038
[Patent] Compound having activity of blocking NMDA receptor channel, and pharmaceutical agent using the same2007
- Inventor(s)
  Igarashi, K., Takayama, H.
- Industrial Property Rights Holder
  Kozai, T.
- Filing Date
  2007-04-26
- Overseas
- Data Source
  KAKENHI-PROJECT-19310137
[Patent] Compound Having Activity of Blocking NMDA Receptor Channel, and Pharmaceutical Agent Using the Same2007
- Inventor(s)
  Kazuei Igarashi, Hiromitsu Takayama
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-19310137
[Patent] アクレイン、インターロイキン-6及びCRPの含有量、並びに被験者の年齢を指標とした脳卒中・無症候性脳梗塞の検出方法2007
- Inventor(s)
  五十嵐一衛並木信重郎吉田円
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2007-132239
- Filing Date
  2007-05-18
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] ポリアミンによる翻訳促進に基づく遺伝子発現調節2021
- Author(s)
  柏木　敬子、坂本　明彦、照井　祐介、植村　武史、五十嵐　一衛
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06714
[Presentation] 脳梗塞急性期におけるグリコサミノグリカン損傷機構の解明2018
- Author(s)
  服部奈津子, 東恭平, 高健太, 石川涼太, 梅原健太, 降幡知巳, 五十嵐一衛, 戸井田敏彦
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] Polyamines reverse the RNA G-quadruplex mediated inhibition during the translation initiation of chondroitin synthase-12017
- Author(s)
  Higashi K, Yamaguchi K, Imamura M, Asakura K, Furihata T, Nishimura K, Sakamoto T, Linhardt RJ, Igarashi K, and Toida T
- Organizer
  Gordon research conference on polyamines (Waterville Valley, NH, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 脳梗塞急性期における糖衣分解機構の解明.2017
- Author(s)
  石川　涼太, 東　恭平, 服部　奈津子, 望月　龍, 今村　正隆, 伊藤　大地, 降幡　知己, 五十嵐　一衛, 戸井田　敏彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明2017
- Author(s)
  朝倉希里生, 東恭平, 今村正隆, 山口勝利, 降幡知巳, 西村和洋, 五十嵐一衛, 戸井田敏彦
- Organizer
  日本薬学会第138年会 (金沢)
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 加齢による脳梗塞悪化とアクロレインの関係並びに新規脳保護薬の開発.2017
- Author(s)
  渡辺健太, 植村武史, 東恭平, 小暮紀行, 北島満里子, 高山廣光, 高尾浩一, 杉田義昭, 西村和洋, 五十嵐一衛, 戸井田敏彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] ポリアミンによるグリコサミノグリカン合成調節機構の解明.2017
- Author(s)
  今村　正隆, 東　恭平, 山口　勝利, 朝倉　希里生, 降幡　知巳, 照井　祐介, 佐武　利彦, 前川　二郎, 安村　和則, 伊吹　愛, 赤瀬　智子, 西村　和洋, 柏木　敬子, Robert J.Linhardt, 五十嵐　一衛, 戸井田　敏彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.2016
- Author(s)
  Kyohei Higashi, Masataka Imamura, Katsutoshi Yamaguchi, Kiryu Asakura, Tomomi Furihata, Yusuke Terui, Toshihiko Satake, Jiro Maegawa, Kazunori Yasumura, Ai Ibuki, Tomoko Akase, Kazuhiro Nishimura, Keiko Kashiwagi, Robert J. Linhardt, Kazuei Igarashi & Toshihiko Toida.
- Organizer
  Gordon Research Conference (Proteoglycans)
- Place of Presentation
  Andover, NH, USA.
- Year and Date
  2016-07-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明.2016
- Author(s)
  朝倉希里生, 東　恭平, 今村正隆, 山口勝利, 降幡知己, 西村和洋, 五十嵐一衛, 戸井田敏彦
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 脳梗塞急性期におけるヘパラン硫酸分解機構の解明.2016
- Author(s)
  石川涼太, 東恭平, 服部奈津子, 降幡知巳, 藤吉正哉, 石井伊都子, 五十嵐一衛, 戸井田敏彦.
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 急性期脳梗塞時におけるヘパラン硫酸分解機構の解明.2016
- Author(s)
  石川涼太, 東恭平, 服部奈津子, 降幡知巳, 藤吉正哉, 石井伊都子, 五十嵐一衛, 戸井田敏彦.
- Organizer
  千葉大学リーディング研究育成プログラム「細胞間クロノ・コミュニケーション」シンポジウム「時間軸から迫る脳機能」
- Place of Presentation
  千葉
- Year and Date
  2016-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] ポリアミンによるコンドロイチン硫酸合成調節機構の解明2016
- Author(s)
  山口勝利, 東　恭平, 今村　正隆, 西村　和洋, 柏木　敬子, 五十嵐　一衛, 戸井田敏彦.
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] Polyamines increase in response to hyperglycemia and protect organisms from sugar toxicity.2015
- Author(s)
  Matsumoto Y, Higashi K, Ishii M, Igarashi K and Sekimizu K.
- Organizer
  Gordon Research Conference (Polyamines)
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] スペルミジンとCa2+はMg2+存在下においてもNMDA受容体を透過できる.2015
- Author(s)
  廣瀬　直雄、東　恭平、斎木　遼太郎、吉沢　祐基、今村　正隆、石井　伊都子、戸井田　敏彦、Williams, Keith、柏木　敬子、五十嵐　一衛
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 糖尿病合併症に対する生体内ポリアミンの防御作用2015
- Author(s)
  松本靖彦，東恭平，石井雅樹、五十嵐一衛，関水和久
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] Effect of polyamines on the synthesis of chondroitin sulfate in mammalian cells2015
- Author(s)
  Higashi K, Yamaguchi K, Imamura M, Furihata T, Terui Y, Kashiwagi K, Linhardt RJ, Igarashi K, and Toida T
- Organizer
  Gordon Research Conference (Polyamines)
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08068
[Presentation] 脳梗塞及び無症候性脳梗塞の血漿中バイオマーカーの開発.2014
- Author(s)
  五十嵐一衛
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Polyamine stimulation of protein synthesis in both prokaryotes and eukaryotes.2014
- Author(s)
  Igarashi, K. et al.
- Organizer
  Third International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
- Place of Presentation
  Ubatuba-SP, Brazil
- Year and Date
  2014-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Mechanism of polyamine stimulation of proteinsynthesis in eukaryotes.2013
- Author(s)
  Igarashi, K.
- Organizer
  Federation of European Biochemical Societies Congress 2013
- Place of Presentation
  St. Petersburg, Russia
- Invited
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] 原核細胞と真核細胞のポリアミンモジュロン:ポリアミンによる遺伝子発現制御の包括的理解2011
- Author(s)
  柏木敬子, 五十嵐一衛
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Correlation of acrolein produced from polyamines with brain infarction-induced cell damage2011
- Author(s)
  Igarashi, K.
- Organizer
  2011 Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2011-06-21
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Strong correlation between brain infarction and acrolein produced from polyamines2011
- Author(s)
  Igarashi, K., et al
- Organizer
  The 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine
- Place of Presentation
  Rhodes Island, Greece
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Polyamine effect on protein synthesis and its mechanism.2009
- Author(s)
  Kashiwagi, K., Terui, Y., Higashi, K., Okudaira, H., Ochiai, E., Tomitori, H., Nishimura, K., Yamamoto, K., Ishihama, A., Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] アフリカツメガエル初期発生に対するポリアミンの影響(1)嚢胚期でのアポトーシス様反応の誘発.2009
- Author(s)
  塩川光一郎、近藤剛士、高橋宣治、五十嵐一衛
- Organizer
  第3回トランスグルタミナーゼ研究会&ポリアミン研究会合同学術集会
- Place of Presentation
  理化学研究所神戸研究所
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Polyamine transport in Escherichia coli and yeast.2009
- Author(s)
  Igarashi, K. et al.
- Organizer
  Polyamines: Forty years of mammalian ornithine decarboxylase
- Place of Presentation
  Kuopio, Finland
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Identification and function of amino acid residues on PotB and PotC involved in spermidine uptake activity.2009
- Author(s)
  Higashi, K., Sakamaki, Y., Uemura, T., Herai, E., Demizu, R., Zenda, R., Toida, T., Kashiwagi, K., Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Binding of spermine and ifenprodil to a regulatory domain (R-domain) of the N-methyl-D-aspartate (NMDA) receptor and the role of R-domain on the activity of NMDA receptor2009
- Author(s)
  Kashiwagi, K., Han, X., Mizuno, S., Tomitori, H., Higashi, K., Terui, Y., Nishimura, K., Toida, T., Williams, K., Igarashi, K.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター場
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 脳梗塞のアクロレイン産生におけるトランスグルタミナーゼ2の役割.2009
- Author(s)
  斎木遼太郎、東恭平、石井伊都子、西村和洋、戸井田敏彦、辰川英樹、小嶋聡一、柏木敬子、五十嵐一衛
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Acrolein as biomarkers in stroke2009
- Author(s)
  Igarashi, K.
- Organizer
  Biogenic Amines : Biochemical, Physiological, and Clinical Aspects
- Place of Presentation
  Bertinoro, Italy
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 細胞周期進行におけるポリアミンの役割解析2009
- Author(s)
  柏木敬子, 山下智子, 西村和洋, 奥平宏之, 當銘真悠子, 東恭平, 藤原邦雄, 五十嵐一衛
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Polyamine effect on protein synthesis and its mechanism2009
- Author(s)
  Kashiwagi, K., Terui, Y., Higashi, K., Okudaira, H., Ochiai, E., Tomitori, H., Nishimura, K., Yamamoto, K., Ishihama, A., Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] ポリアミン酸化により産生されるアクロレインの毒性:活性酸素種との比較.2009
- Author(s)
  富取秀行、吉田円、町佳樹、萩原基文、東恭平、合田ひとみ、大谷武司、新津勝、柏木敬子、五十嵐一衛
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] スペルミン及びイフェンプロジルのNMDA受容体調節領域への結合能2009
- Author(s)
  韓霞, 富取秀行, 水野聡美, 東恭平, 吹譯友秀, 照井祐介, 西村和洋, 戸井田敏彦, 柏木敬子, 五十嵐一衛
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] ポリアミンか産生されるアクロレインの脳梗塞形成に及ぼす効果.2009
- Author(s)
  斎木遼太郎、東恭平、石井伊都子、西村和洋、戸井田敏彦、池口文彦、A.E.Pegg、柏木敬子、五十嵐一衛
- Organizer
  東京慈恵会医科大学学外共同研究シンポジウムポリアミンと核酸の共進化第8回合同シンポジウム
- Place of Presentation
  東京慈恵会医科大学
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] ポリアミン酸化により産生されるアクロレインの毒性 : 活性酸素種との比較2009
- Author(s)
  富取秀行, 吉田円, 町佳樹, 萩原基文, 東恭平, 合田ひとみ, 大谷武司, 新津勝, 柏木敬子, 五十嵐一衛
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Polyamine stimulation of the synthesis of RpoE and StpA at the level of translatiohn in Escherichia coli under heat shock conditions.2009
- Author(s)
  Terui, Y., Tabei, Y., Higashi, K., Tomitori, H., Yamamoto, K., Ishihama, A., Igarashi, K., Kashiwagi, K.
- Organizer
  Biogenic Amines : Biochemical, Physiological, and Clinical Aspects
- Place of Presentation
  Bertinoro, Italy
- Year and Date
  2009-05-14
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Binding of spermine and ifenprodil to a regulatory domain (R-domain) of the N-methyl-D-aspartate (NMDA) receptor and the role of R-domain on the activity of NMDA receptor.2009
- Author(s)
  Kashiwagi, K., Han, X., Mizuno, S., Tomitori, H., Higashi, K., Terui, Y., Nishimura, K., Toida, T., Williams, K., Igarashi, K.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学コンベンションセンター
- Year and Date
  2009-12-01
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Intense correlation between brain infarction and protein-conjugated acrolein.2009
- Author(s)
  Saiki, R., Nishimura, K., Ishii, I., Omura, T., Okuyama, S., Kashiwagi, K., Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 脳梗塞時のアクロレイン産生におけるトランスグルタミナーゼ2の役割2009
- Author(s)
  斎木遼太郎, 東恭平, 石井伊都子, 西村和洋, 戸井田敏彦, 辰川英樹, 小嶋聡一, 柏木敬子, 五十嵐一衛
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] マウス神経芽細胞腫Neuro2aにおけるアクロレイン耐性機構の探索.2009
- Author(s)
  坂本明彦、富取秀行、中村瑞穂、照井祐介、吉田円、柏木敬子、五十嵐一衛
- Organizer
  東京慈恵会医科大学学外共同研究シンポジウムポリアミンと核酸の共進化第8回合同シンポジウム
- Place of Presentation
  東京慈恵会医科大学
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] アクロレイン耐性細胞の樹立とそのアクロレイン毒性除去機構.2009
- Author(s)
  中村瑞穂、富取秀行、照井祐介、吉田円、柏木敬子、五十嵐一衛
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Acrolein as biomarkers in stroke.2009
- Author(s)
  Igarashi, K.
- Organizer
  Biogenic Amines : Biochemical, Physiological, and Clinical Aspects
- Place of Presentation
  Bertinoro, Italy
- Year and Date
  2009-05-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Isolation and characterization of an acrolein tolerant mutant of FM3A cells.2009
- Author(s)
  Tomitori, H., Nakamura, M., Yoshida, M., Kashiwagi, K., Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2009-06-24
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] スペルミンによるNMDA受容体活性促進効果とチャネルブロック作用に影響するチャネル領域の同定2008
- Author(s)
  柏木敬子, 金麗花, 宮崎真紀, 水野聡美, 瀧川美紀, 廣瀬直雄, 西村和洋, 戸井田敏彦, K. Williams, 五十嵐一衛
- Organizer
  第30回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2008-08-08
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 大腸菌OppAmRNA及びラット肝lle-tRNAにおける二重鎖RNAのバルジ構造のスペルミンによる選択的な構造変化2008
- Author(s)
  東恭平,菅波晃子,田村裕,照井裕介,西村和彦,柏木敬子,五十嵐一衛
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 定常期におけるポリアミンの大腸菌の生存率維持に果たす役割2008
- Author(s)
  照井裕介,東恭平,田部井譲,秋山真律子,富取秀行,山本兼由,石浜明,五十嵐一衛,柏木敬子
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 大腸菌スペルミジン優先取り込み系の膜貫通蛋白質 PotB及び PotCの性質2008
- Author(s)
  出水梨沙, 東恭平, 酒巻善春, 植村武史, 戸来江美子, 善田理沙, 西村和洋, 柏木敬子, 五十嵐一衛
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] アフリカツメガエル胚発生に対するポリアミンの作用2008
- Author(s)
  塩川光一郎,近藤剛士,麻生舞,高井惇一,田久保繁樹,見村朋美,高橋宜治,梶谷正行,照井裕介,五十嵐一衛
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ボートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 大腸菌 OppA mRNA及びラット肝Ile-tRNAにおける二重鎖RNAのバルジ構造のスペルミンによる選択的な構造変化2008
- Author(s)
  東恭平, 菅波晃子, 田村裕, 照井裕介, 西村和洋, 柏木敬子, 五十嵐一衛
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 大腸菌スペルミジン優先取り込み系の膜貫通蛋白質PodB及びPotCの性質2008
- Author(s)
  出水梨沙,東恭平,酒巻善春,植村武史,戸来江美子,善田理沙,西村和彦,柏木敬子,五十嵐一衛,木敬子,五十嵐一衛
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] NMDA受容体の膜領域の構造の解析2008
- Author(s)
  金麗花, 田村真紀, 瀧川美紀, 廣瀬直雄, 西村和洋, 戸井田敏彦, K. Williams, 柏木敬子, 五十嵐一衛
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] Acrolein toxicity : its mechanism and comparison of toxicity with reactive oxygen species2007
- Author(s)
  Yoshida, M., Hagihara, M., Tomitori, H., Nishimura, K., Kashiwagi, K., Igarashi, K.
- Organizer
  International Congress on Biogenic Amines : Biological and Clinical Perspectives
- Place of Presentation
  Sicily, Italy
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] A unifying model for the role of polyamines in bacterial cell growth, the polyamine modulon2007
- Author(s)
  Igarashi, K.
- Organizer
  Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2007-07-17
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 三環性複素環とポリアミンのハイブリッド型構造を有する新規NMDA受容体阻害剤の創製研究2007
- Author(s)
  八重樫優一, 北島満里子, 韓霞, 西村和洋, 奥山茂, 五十嵐一衛, 高山廣光
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-29
- Data Source
  KAKENHI-PROJECT-19310137
[Presentation] A unifying model for the role of polyamines in bacterial cell growth, polyamine modulon2007
- Author(s)
  Igarashi, K
- Organizer
  Polyamine Gordon Research Conference
- Place of Presentation
  Waterville Valley, NH, USA
- Year and Date
  2007-06-17
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 動物細胞のポリアミンにより翻訳レベルで合成促進を受ける蛋白質の同定2007
- Author(s)
  落合絵里子, 奥平宏之, 西村和洋, 柏木敬子, 堂前直, 西村友枝, 瀧尾擴士, 五十嵐一衛
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19390016
[Presentation] 細胞傷害時にポリアミンから産生されるアクロレインの毒性とその臨床応用.
- Author(s)
  五十嵐一衛
- Organizer
  日本ポリアミン学会第5回年会
- Place of Presentation
  千葉科学大学マリーナキャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Toxicity of acrolein produced from polyamines during brain infarction.
- Author(s)
  Igarashi, K.
- Organizer
  2013 Gordon Research Conference on Polyamines
- Place of Presentation
  Waterville Valley, NH, USA
- Invited
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Estimation of brain stroke by acrolein derivatives in plasma and urine.
- Author(s)
  Igarashi, K.
- Organizer
  International Congress on “Polyamines: Biological and Clinical Perspectives”
- Place of Presentation
  Istanbul, Turky
- Invited
- Data Source
  KAKENHI-PROJECT-23390038
[Presentation] Biochemistry of polyamines: molecules modulating diverse cellular function in all living organisms.
- Author(s)
  Igarashi, K.
- Organizer
  13th FAOBMB
- Place of Presentation
  Bangkok, Thailand
- Invited
- Data Source
  KAKENHI-PROJECT-23390038

1. KASHIWAGI Keiko (80169424)

# of Collaborated Projects: 20 results

# of Collaborated Products: 55 results
2. KAKINUMA Yoshimi (80134394)

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# of Collaborated Products: 0 results
3. SHIRAHATA Akira (50150107)

# of Collaborated Projects: 5 results

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4. NISHIMURA Kazuhiro (60302569)

# of Collaborated Projects: 4 results

# of Collaborated Products: 30 results
5. KOBAYASHI Hiroshi (00090473)

# of Collaborated Projects: 4 results

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6. JAMARI F.

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8. FRIESEN

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47. 鈴木不二男 (40028717)

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48. 山根靖弘 (40009155)

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49. 仲井由宣 (80009159)

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50. 細谷東一郎 (10019648)

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51. STEFANIA Biondi

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52. NELLO Bagni

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53. BIGGS D. F.

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54. KNAUS E. E.

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55. LOCOCK R. A.

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56. PASUTTO F. M.

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57. FRIESEN A. J. D.

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58. COUTTS R. T.

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59. TAM Y. K.

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60. NOUJAIM A. A.

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61. WOLOWYK M. W.

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62. MICETICH R. G.

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63. MOSKALYK R. E.

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64. WIEBE L. I.

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65. COUTIS

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66. 解良康太

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67. 松村浩由

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68. 鈴木秀之

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69. 坂本明彦

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Igarashi Kazuei 五十嵐 一衛

五十嵐 一衛 イガラシ カズエイ

IGARASHI Kazuei 五十嵐 一衛

五十嵐 一衞 イガラシ カズエイ

Research Projects

Research Products

Co-Researchers

細胞増殖因子ポリアミンの生理機能解析とその毒性代謝物アクロレインの除去剤の探索

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Degradation of glycosaminoglycans in cerebral infarction

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Elucidation of molecular mechanism of cellular toxicity of acrolein and its clinical applicationPrincipal Investigator

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新規NMDA受容体チャネルブロッカー探索による脳機能改善薬の創製

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Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.

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Elucidation of function of polyamines and regulation of their contents in cellsPrincipal Investigator

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ポリアミンモジュロンによる細胞増殖と生存率の調節Principal Investigator

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Regulation of cell growth and brain function by polyaminesPrincipal Investigator

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ポリアミンモジュロンによる細胞増殖と生存率の調節Principal Investigator

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ポリアミンレギュロンによる細胞増殖と生存率の調節Principal Investigator

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ポリアミンによるRNA機能のモジュレーションPrincipal Investigator

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Modulation of cellular functions by polyamines through polyamine interaction with RNA and proteinsPrincipal Investigator

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蛋白質合成開始因子eIF4E,4G及び5Aによる遺伝子発現調節Principal Investigator

Igarashi Kazuei 五十嵐一衛

五十嵐一衛イガラシカズエイ

IGARASHI Kazuei 五十嵐一衛

五十嵐一衞イガラシカズエイ