nakayama masamichi 中山正道

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Nakayama Masamichi 中山正道

NAKAYAMA Masamichi 中山正道

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Researcher Number	00338980
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東京女子医科大学, 医学部, 講師 2018 – 2022: 東京女子医科大学, 医学部, 講師 2008 – 2016: Tokyo Women's Medical University, 医学部, 講師 2015: 東京女子医科大学, 医学部薬, 講師 2007: Tokyo Women's Medical University, 医学部, 助教 2002 – 2006: 東京女子医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / Biomedical engineering/Biomaterial science and engineering / Basic Section 90120:Biomaterials-related / Basic Section 90110:Biomedical engineering-related / Biomedical engineering/Biological material science Except Principal Investigator Digestive surgery / Biomedical engineering/Biological material science / Basic Section 90120:Biomaterials-related / General surgery / Science and Engineering
Keywords	Principal Investigator ポリ(N-イソプロピルアクリルアミド) / 薬物キャリア / ドラッグデリバリーシステム / 高分子ミセル / 細胞シート / コーティング / 組織工学 / ブロックコポリマー / 温度応答性 / RAFT重合 … More / 温度応答性高分子 / 灌流培養 / 担癌モデル動物 / 腫瘍モデル / がん組織工学 / 過重力 / がん細胞 / 細胞パッチ / 細胞接着 / 疎水性表面 / スピロピラン / 細胞接着制御 / スピロベンゾピラン / フルオロポリマー / 光応答性 / バイオリアクター / バイオイメージング / 癌 / 薬剤反応性 / 薬剤応答性 / がんモデル / がん / ナノ相分離 / 細胞 / 細胞コーティング / 細胞内移行 / 蛍光標識 / ポリ(ルイソプロピルアクリルアミド) / pH応答性 / 表面機能化 / 薬物伝達システム / 可逆的負荷-開裂連鎖移動型ラジカル重合 / ターゲティング / 抗腫瘍効果 / 温度応答 / 局所加温 / 薬物治療 … More Except Principal Investigator 組織工学 / 再生医療 / 細胞シート / 分子標的治療 / 糖鎖医学 / 肝内胆管癌 / 遺伝子治療 / 血管前駆細胞 / 血管内皮前駆細胞 / mRNA送達 / 脈管形成 / 血管新生 / Cell growth factor / Temperature responsive cell culture dish / Serum free / Regenerative medicine / Tissue engineering / シナジー配列 / RGD / フィブロネクチン / インスリン / 細胞成長因子 / 温度応答性培養皿 / 無血清培養 / Nrf2 / 動物モデル / 転写因子 / 肝発癌 / 脂肪性肝炎 / 肥満 / 胆道癌モデル / バイオマーカー / 糖蛋白質 / レクチン / 糖鎖構造解析 / 胆道癌 / 細胞移植 / 血液凝固因子 / 細胞遺伝子治療 / 血友病 / 受容体 / サイトカイン / ハイブリッドペプチド / 胆道系悪性腫瘍 / フォトリソグラフィー / 肝様組織構造 / 微細加工 / 肝組織様構造 / 温度応答性高分子 / 微細加工技術 / 肝小葉 / 成長因子 / 肝細胞シート / 軟組織 / 共培養 / 温度応答性細胞培養表面 / 肝細胞 / 細胞シート工学 / 標的治療 / 糖鎖分子 / 悪性挙動 / 糖転移酵素 / 胆嚢癌 / 免疫隔離 / 細胞表面修飾 / 細胞治療 / 細胞・組織工学 Less

高度な細胞接着制御を実現する機能性高分子ナノコート界面の創製Principal Investigator
- Principal Investigator
  
  中山正道
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Women's Medical University
Development of innovative human tumor models using cell patch method for high-speed three-dimensional organizationPrincipal Investigator
- Principal Investigator
  
  Nakayama Masamichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tokyo Women's Medical University
Induction of vasculogenesis and angiogenesis in three-dimensional tissues by using protein expressions with mRNA delivery
- Principal Investigator
  
  Kobayashi Jun
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Women's Medical University
Photo-controlled surface water repellency for smart cell separation systemPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA MASAMICHI
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Women's Medical University
Cancer cell sheet tissue engineering for development of innovative three-dimensional cancer tissue modelsPrincipal Investigator
- Principal Investigator
  
  Nakayama Masamichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Women's Medical University
Nrf2 activation inhibits steatohepatitis and liver cancer in overeating-induced obese mice.
- Principal Investigator
  
  Ariizumi Syunnichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Tokyo Women's Medical University
Cell-based Therapies Toward Hemophilia Using Autologous Cells from Hemophilic Individuals
- Principal Investigator
  
  OHASHI KAZUO
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Osaka University
  Nara Medical University
  Tokyo Women's Medical University
Development of glycoprotein-biomrkers for biliary tract cancers and establishment of novel diagnostic system using the combination of these biomarkers
- Principal Investigator
  
  YAMAMOTO Masakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo Women's Medical University
Fabrication of structually comlicated soft tissue such as liver-tissues and understanding its biological function of teh fabricated liver-tissue
- Principal Investigator
  
  YAMATO MASAYUKI
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Women's Medical University
Development of novel bio-therapy using hybrid peptide against intrahepatic cholangiocarcinoma
- Principal Investigator
  
  ISHIGE Kazunori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
Exploration of carbohydrate molecules that regulate malignant behaviors of intrahepatic cholangiocarcinoma, and application for the development of novel molecular-targeting therapy
- Principal Investigator
  
  ARIIZUMI Syunnichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tokyo Women's Medical University
Development of liver-target therapy based on cellular modification technology
- Principal Investigator
  
  OHASHI Ohashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
Creation of thermoresponsive nano-phase separated surfaces for cell adhesion and detachmentPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Masamichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
Newly molecular design of outermost surface functionalized thermoresponsive nano-micelles for drug carrier systemsPrincipal Investigator
- Principal Investigator
  
  NAKAYAMA Masamichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
ガン局所加温により抗腫瘍効果を発現する高分子ミセル型薬物キャリアの分子設計Principal Investigator
- Principal Investigator
  
  中山正道
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
Development of novel intelligent tissue culture surfaces to accelerate cell proliferation and recover cell sheet under serum free conditions, using physiologically active peptides
- Principal Investigator
  
  OKANO Teruo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Woman's Medical University
温度刺激で高速に薬物を放出する高分子ミセルの分子設計Principal Investigator
- Principal Investigator
  
  中山正道
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University

[Book] Hyper Bio Assembler for 3D Cellular Systems2015
- Author(s)
  FUKUMORI Kazuhiro, TAKAHASHI Hironobu, KOBAYASHI Jun, NAKAYAMA Masamichi, AKIYAMA Yoshikatsu, YAMATO Masayuki
- Total Pages
  349
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23106009
[Book] DDS研究30年　温故知新2015
- Author(s)
  中山正道, 秋元淳, 岡野光夫
- Total Pages
  6
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-25282145
[Book]
- Author(s)
  中山正道, 岡野光夫
- Data Source
  KAKENHI-PROJECT-16700368
[Journal Article] Micropatterned Smart Culture Surfaces via Multi‐Step Physical Coating of Functional Block Copolymers for Harvesting Cell Sheets with Controlled Sizes and Shapes2020
- Author(s)
  Nakayama Masamichi、Toyoshima Yuki、Kikuchi Akihiko、Okano Teruo
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 21 Issue: 3 Pages: 2000330-2000330
- DOI
  10.1002/mabi.202000330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04454
[Journal Article] リビングラジカル重合-可逆的付加開裂連鎖移動重合2020
- Author(s)
  中山正道
- Journal Title
  
  Drug Delivery System
  
  Volume: 36 Pages: 69-71
- Data Source
  KAKENHI-PROJECT-19H04454
[Journal Article] Water stable nanocoatings of poly(N-isopropylacrylamide)-based block copolymers on culture insert membranes for temperature-controlled cell adhesion2020
- Author(s)
  Nakayama Masamichi、Toyoshima Yuki、Chinen Hiroshi、Kikuchi Akihiko、Yamato Masayuki、Okano Teruo
- Journal Title
  
  Journal of Materials Chemistry B
  
  Volume: 8 Issue: 34 Pages: 7812-7821
- DOI
  10.1039/d0tb01113d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04454
[Journal Article] 生体に学ぶ3次元がん組織モデルへのアプローチ2015
- Author(s)
  秋元淳, 中山正道, 岡野光夫
- Journal Title
  
  バイオマテリアル
  
  Volume: 33 Pages: 236-245
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] A Biomimicking Tumor Tissue Model Using Hepatocellula Carcinoma Cell Sheet in a Collagen Sandwich System2015
- Author(s)
  Iwase Yuko, Nakayama Masamichi, Yamato Masayuki, Okano Teruo
- Journal Title
  
  Anticancer Research
  
  Volume: 35 Pages: 6481-6486
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Anisotropic cellular network formation in engineered muscle tissue through the self-organization of neurons and endothelial cells2015
- Author(s)
  Hironobu Takahashi, Tatsuya Shimizu, Masamichi Nakayama, Masayuki Yamato, Teruo Okano
- Journal Title
  
  Advanced Healthcare Materials
  
  Volume: 4 Issue: 3 Pages: 356-360
- DOI
  10.1002/adhm.201400297
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26702018, KAKENHI-PLANNED-23106009
[Journal Article] Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors2014
- Author(s)
  Akimoto Jun, Nakayama Masamichi, Okano Teruo
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 193 Pages: 2-8
- DOI
  10.1016/j.jconrel.2014.06.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Polymeric micelles with stimuli-triggering systems for advanced cancer drug targeting2014
- Author(s)
  Nakayama Masamichi, Akimoto Jun, Okano Teruo
- Journal Title
  
  Journal of Drug Targeting
  
  Volume: 22 Issue: 7 Pages: 584-599
- DOI
  10.3109/1061186x.2014.936872
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells2014
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K
- Journal Title
  
  Int J Hepatol
  
  Volume: 未定 Pages: 584650-584650
- DOI
  10.1155/2014/584650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300250, KAKENHI-PROJECT-24390323, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25293278, KAKENHI-PROJECT-26282191, KAKENHI-PROJECT-26293284
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells.2014
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami Y.
- Journal Title
  
  Int J Hepatol
  
  Volume: 10 Pages: 1155-1161
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293278
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in biliary tract cancer cells.2014
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami Y.
- Journal Title
  
  Int J Hepatol
  
  Volume: 10 Pages: 1155-1161
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390323
[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014
- Author(s)
  Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 74 Pages: 9-17
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390323
[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress.2014
- Author(s)
  Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 74 Pages: 9-17
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293278
[Journal Article] Peroxidoxin I plays a ptotective role against UVA irradiation through reduction of oxidative stress2014
- Author(s)
  Ito T, Kimura S, Seto K, Warabi E, Kawauchi Y, Shoda J, Tabuchi K, Yamagata K, Hasegawa S, Bukawa H, Ishii T, Yanagawa T
- Journal Title
  
  J Dermatol Sci
  
  Volume: 74 Pages: 9-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390318
[Journal Article] Facile cell sheet manipulation and transplantation by using in situ gelation method2014
- Author(s)
  Akimoto Jun, Arauchi Ayumi, Nakayama Masamichi, Kanaya Ryo, Iwase Yuko, Takagi Soichi , Yamato Masayuki, Okano Teruo
- Journal Title
  
  Journal of Biomedical Materials Research Part B: Applied Biomaterials
  
  Volume: 102B Issue: 8 Pages: 1659-1668
- DOI
  10.1002/jbm.b.33148
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25282145
[Journal Article] The use of anisotropic cell sheets to control orientation during the self-organization of 3D muscle tissue2013
- Author(s)
  Takahashi H, Shimizu T, Nakayama M, Yamato M, Okano T
- Journal Title
  
  Biomaterials
  
  Volume: 34 Issue: 30 Pages: 7372-7380
- DOI
  10.1016/j.biomaterials.2013.06.033
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23106009
[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
- Author(s)
  Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
- Journal Title
  
  J Neuroscience
  
  Volume: 33 Pages: 14767-14777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293278
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
- Journal Title
  
  Oncology Report
  
  Volume: 29 Pages: 2147-2153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390323
[Journal Article] Terminal-Functionality Effect of Poly (N-isopropylacrylamide) Brush Surfaces on T emperature-Controlled Cell Adhesion/Detachment2013
- Author(s)
  Naoki Matsuzaka
- Journal Title
  
  Biomacromolecules
  
  Volume: 14 Issue: 9 Pages: 3164-3171
- DOI
  10.1021/bm400788p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07141, KAKENHI-PLANNED-23106009
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
- Journal Title
  
  Oncology Report
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22591530
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
- Journal Title
  
  Oncology Report
  
  Volume: 29 Pages: 2147-2153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390318
[Journal Article] Negative expression of N-acetylglucosaminyltransferase V in oral squamous cell carcinoma correlates with poor prognosis.2013
- Author(s)
  Seto K, Uchida F, Baba O, Miyoshi E,et.al.
- Journal Title
  
  Springerplus
  
  Volume: 2 Issue: 1 Pages: 657-657
- DOI
  10.1186/2193-1801-2-657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249038, KAKENHI-PROJECT-23300250, KAKENHI-PROJECT-23390318, KAKENHI-PROJECT-23500835, KAKENHI-PROJECT-24390323, KAKENHI-PROJECT-24650436, KAKENHI-PROJECT-24659104, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25293278
[Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013
- Author(s)
  Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K: Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma
- Journal Title
  
  Oncology Report
  
  Volume: 29 Pages: 2147-2153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293278
[Journal Article] Thermoresponsive poly (N-isopropylacrylamide)- based block copolymer coating for optimizing cell sheet fabrication2012
- Author(s)
  Nakayama M, Yamada N, Kumashiro Y, Kanazawa H, Yamato M, Okano T.
- Journal Title
  
  Macromol Biosci
  
  Volume: 12 Pages: 751-60
- Data Source
  KAKENHI-PROJECT-22591530
[Journal Article] Amelioration of cisplatin-induced nephrotoxicity in Peroxiredoxin I-deficient mice2012
- Author(s)
  Okada K, Ma D, Warabi E, Morito N, Akiyama K, Yamagata K, Bukawa H, Shoda J, Ishii T, Yanagawa T
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 71 Pages: 503-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390318
[Journal Article] Proton beam therapy for hepatocellular carcinoma located adjacent to the alimentary tarct2011
- Author(s)
  Nakayama H, Sugahara S, Fukuda K, Abei M, Shoda J, T okita M, Sakurai H, T suboi K, Matsuzaki Y, T okuue K
- Journal Title
  
  Int J Radiat Oncol Biol Phys
  
  Volume: 80 Pages: 992-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390318
[Journal Article] Micropatterned thermoresponsive polymer brush surfaces for fabricating cell sheets with well-controlled orientational structures2011
- Author(s)
  Takahashi H, Nakayama M, Itoga K, Yamato M, Okano T.
- Journal Title
  
  Biomacromolecules
  
  Volume: 12 Pages: 1414-8
- Data Source
  KAKENHI-PROJECT-22591530
[Journal Article] Thermally controlled intracellular uptake system of polymeric micelles possessing poly (N-isopropylacrylamide)-based outer coronas2010
- Author(s)
  Akimoto J, Nakayama M, Sakai K, Okano T.
- Journal Title
  
  Mol Pharm
  
  Volume: 7 Pages: 926-35
- Data Source
  KAKENHI-PROJECT-22591530
[Journal Article] Molecular Design of Outermost Surface Functionalized Thermoresponsive Polymeric Micelles with Biodegradable Cores2008
- Author(s)
  Jun Akimoto, Masamichi Nakayama, Kiyotaka Sakai, Teruo Okano
- Journal Title
  
  J. Polym. Sci., Part A, Polym. Chem. 46
  
  Pages: 7127-7137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Molecular Design of Outermost Surface Functionalized Thermo-responsive Polymeric Micelles with Biodegradable Cores2008
- Author(s)
  J. Akimoto, M. Nakayama, K. Sakai, T. Okano
- Journal Title
  
  J. Polvm. Polvm., Part A, Polym. Chem 46
  
  Pages: 7127-7137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Unique Thermoresponsive Polymeric Micelle Behavior via Cooperative Polymer Corona Phase Transitions2008
- Author(s)
  Masamichi Nakayama, Teruo Okano
- Journal Title
  
  Macromolecules 41
  
  Pages: 504-507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Unique Thermoresponsive Polymeric Micelle Behavior via Cooperative Polymer Corona Phase Transitions2008
- Author(s)
  M. Nakayama and T. Okano
- Journal Title
  
  Macromolecules 41
  
  Pages: 504-507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Thermal modulation of intracellular drug distribution using thermoresponsive poly meric micelles2007
- Author(s)
  M. Nakayama, J. E. Chung, T. Miyazaki, M. Yokoyama, T. Okano
- Journal Title
  
  Reactive & Functional Polymers 67
  
  Pages: 1398-1407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Thermal modulation of intracellular drug distribution using thermoresponsive polymeric micelles2007
- Author(s)
  Masamichi Nakayama, Joo Eun Chung, Takanari Miyazaki, Masayuki Yokoyama, Teruo Okano
- Journal Title
  
  Reactive & Functional Polymers 67
  
  Pages: 1398-1407
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Polymer Terminal Group Effects on Properties of Thermoresponsive Polymeric Micelles with Controlled Outer-Shell Chain Lengths2005
- Author(s)
  Masamichi Nakayama, Teruo Okano
- Journal Title
  
  Biomacromolecules 6
  
  Pages: 2320-2327
- Data Source
  KAKENHI-PROJECT-16700368
[Journal Article] Temperature-Induced Intracellular Uptake of Thermoresponsive Polymeric
- Author(s)
  Jun Akimoto, Masamichi Nakayama, Kiyotaka Sakai, Teruo Okano
- Journal Title
  
  Biomacromolecules (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Journal Article] Temperature-Modulated Intracellular Localization of Thermores-nonsive Polymeric Micelles
- Author(s)
  J. Akimoto, M. Nakayama, K. Sakai, T. Okano
- Journal Title
  
  Biomacromolecules (accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700407
[Presentation] ポリスチレン表面改質が温度応答性培養基材の細胞接着性に及ぼす影響とその応用2022
- Author(s)
  中山正道、岡野光夫
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Micropatterned Thermoresponsive Surfaces via Physical Block Copolymer Coatings for Fabricating Cell Sheets with Designed Morphological Structures2022
- Author(s)
  Nakayama Masamichi, Tonegawa Junichi, Kikuchi Akihiko, Okano Teruo
- Organizer
  2022 Hawaii-Joint Symposium-SFB+JSB
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] ポリスチレンベース基材の表面改質が温度応答性ナノ薄膜表面への細胞接着に及ぼす影響2022
- Author(s)
  中山正道、岡野光夫
- Organizer
  第44回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Micropatterned Smart Surfaces via Physical Polymer Coatings for Fabricating Cell Sheets with On-demand Morphological Structures2021
- Author(s)
  Nakayama Masamichi, Tonegawa Junichi, Kikuchi Akihiko, Okano Teruo
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Biomaterials and the 8th Asian Biomaterials Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] ポリマースタンプ法で作製したパターン化スマート表面を用いた細胞シートの構造制御2020
- Author(s)
  中山正道、利根川純一、菊池明彦、大和雅之、岡野光夫
- Organizer
  第15回ナノ・バイオメディカル学会大会
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Transplantation of sheet-like cancer cell tissues for orthotopic tumor-bearing animal models2020
- Author(s)
  Nakayama Masamichi、Akimoto Jun、Okano Teruo
- Organizer
  47th Annual Meeting of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] 親水性基を導入した温度応答性ブロック共重合体コート表面における細胞接着/脱着挙動2020
- Author(s)
  北嶋健太郎、中山正道、菊池明彦、岡野光夫
- Organizer
  第69回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Stimuli-responsive polymer nanocoatings on culture substrates for smart cell adhesion control2020
- Author(s)
  Nakayama Masamichi
- Organizer
  The 30th Frontier Scientists Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Controlled structure of cell sheets using micropatterned thermoresponsive surfaces prepared by polymer stamping method2019
- Author(s)
  Masamichi Nakayama, Junichi Tonegawa, Akihiko Kikuchi, Teruo Okano
- Organizer
  30th Annual Conference of the European Society for Biomaterials
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04454
[Presentation] Visible light-triggered cell recovery system from intelligent fluoropolymer coated surface2016
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  3rd International Conference on Biomaterials Science
- Place of Presentation
  東京大学伊藤国際学術センター（東京都文京区）
- Year and Date
  2016-11-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12547
[Presentation] Photo-responsive fluoropolymer coated surface for cell adhesion control2016
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  10th World Biomaterials Congress
- Place of Presentation
  モントリオール（カナダ）
- Year and Date
  2016-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12547
[Presentation] Light-sensitive Fluoropolymer Coated Surfaces for Smart Cell Recovery System2016
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  BIT’s 2nd Annual World Congress of Smart Materials-2016
- Place of Presentation
  シンガポール
- Year and Date
  2016-03-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Visible light-triggered cell detachment system using smart fluoropolymer coated surface2016
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  11th SPSJ International Polymer Conference
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-12-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12547
[Presentation] Visible-light induced cell detachment system using smart fluoropolymer-coated surface2016
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  10th World Biomaterials Congress
- Place of Presentation
  モントリオール（カナダ）
- Year and Date
  2016-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12547
[Presentation] Effective Fabrication of Tumor-bearing Animal Models by Cancer Cell Sheet Transplantation2015
- Author(s)
  Masamichi Nakayama, Jun Akimoto, Masayuki Yamato, Teruo Okano
- Organizer
  The 42nd CRS Annual Meeting & Exposition
- Place of Presentation
  エジンバラ（スコットランド）
- Year and Date
  2015-07-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Light-responsive fluoropolymer coated surface for dynamic control of cell adhesion2015
- Author(s)
  Nakayama Masamichi, Kanno Tomonori, Kikuchi Akihiko, Okano Teruo
- Organizer
  4th International Conference on Multifunctional, Hybrid and Nanomaterials
- Place of Presentation
  Sitges, Spain
- Year and Date
  2015-03-09
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Photo-responsive Fluoropolymer Coated Surface for Cell Adhesion Control2015
- Author(s)
  Masamichi Nakayama, Tomonori Kanno, Akihiko Kikuchi, Teruo Okano
- Organizer
  The 27th European Conference on Biomaterials
- Place of Presentation
  クラクフ（ポーランド）
- Year and Date
  2015-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Light-sensitive Fluoropolymer Coated Surface for Control of Cell Adhesion Behavior2015
- Author(s)
  Nakayama M, Kanno T, Kikuchi A, and Okano T
- Organizer
  Society for Biomaterials 2015 Annual Meeting & Exposition (SFB2015)
- Place of Presentation
  Charlotte, USA
- Year and Date
  2015-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] 温度応答性ブロック共重合体コーティングによる多孔性培養基材の作製と特性評価2015
- Author(s)
  豊島侑樹, 中山正道, 菊池明彦, 大和雅之, 岡野光夫
- Organizer
  第37回バイオマテリアル学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-10
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] 細胞シート工学の基礎研究と将来展望2014
- Author(s)
  中山正道
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学芝共立キャンパス（東京都・港区）
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Nano-scale surface coating of Poly(N-isopropylacrylamide)-based block copolymers for cell sheet harvest2014
- Author(s)
  Nakayama Masamichi, Kimura Yurika, Kanazawa Hideko, Yamato Masayuki, Okano Teruo
- Organizer
  15th IUMRS-International Conference in Asia
- Place of Presentation
  福岡大学（福岡県・福岡市）
- Year and Date
  2014-08-26
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] Construction of cell sheet-based 3D tissues with designed cell orientation using anisotropic cell sheets2014
- Author(s)
  Hironobu Takahashi, Tatsuya Shimizu, Masamichi Nakayama, Masayuki Yamato, Teruo Okano
- Organizer
  5th 2014 International Symposium on Micro-NanoMechatronics and Human Science
- Place of Presentation
  Nagoya, Aichi
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] 光スイッチングにより細胞接着・脱着制御を実現する撥水性ポリマーコーティング表面の構築2014
- Author(s)
  菅野智規, 中山正道, 菊池明彦, 岡野光夫
- Organizer
  第63回高分子討論会
- Place of Presentation
  長崎大学文教キャンパス（長崎県・長崎市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] 温度応答性高分子材料を用いたDDS研究へのアプローチ2014
- Author(s)
  中山正道, 岡野光夫
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学芝共立キャンパス（東京都・港区）
- Year and Date
  2014-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] 細胞の接着・脱着を制御する温度応答性ブロック共重合体コーティング表面の構築2011
- Author(s)
  山田奈央子, 中山正道, 金澤秀子, 岡野光夫
- Organizer
  第59回高分子討論会
- Place of Presentation
  北海道札幌市
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] インテリジェント細胞培養表面のための温度応答性ブロック共重合体コーティング技術の確立2011
- Author(s)
  中山正道・山田奈央子・金澤秀子・岡野光夫
- Organizer
  第20回インテリジェント材料/システムシンポジウム
- Place of Presentation
  東京女子医科大学・早稲田大学連携先端生命医科学研究教育施設
- Year and Date
  2011-01-06
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] インテリジェント細胞培養表面のための温度応答性ブロック共重合体コーティング技術の確立2011
- Author(s)
  中山正道, 山田奈央子, 金澤秀子, 岡野光夫
- Organizer
  第20回インテリジェント材料/システムシンポジウム
- Place of Presentation
  東京都新宿区
- Year and Date
  2011-01-06
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] Outermost surface functionalized thermoresponsive polymeric micelles for biomedical applications2010
- Author(s)
  Masamichi Nakayama, Yayoi Kawahara, Hideko Kanazawa, Teruo Okano
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ホノルル(アメリカ)
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] Outermost surface functionalized thermoresponsive polymericmicelles for biomedical applications2010
- Author(s)
  Masamichi Nakayama, Yayoi Kawahara, Hideko Kanazawa, Teruo Okano
- Organizer
  The 2010 International Chemical Congress of Pacific Basin Societies
- Place of Presentation
  ホノルル(アメリカ)
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] 細胞の接着・脱着を制御する温度応答性ブロック共重合体コーティング表面の構築2010
- Author(s)
  山田奈央子・中山正道・金澤秀子・岡野光夫
- Organizer
  第59回高分子討論会
- Place of Presentation
  北海道大学
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-21700493
[Presentation] Molecular Design of Thermoresponsive Polymeric Micelles with Surface DH-Responsive Sulfonamide Moieties2009
- Author(s)
  M. Nakayama, Y. Kawahara, H. Kanazawa, T. Okano
- Organizer
  14th International Symposium on Recent A dvances in Drug Delivery Systems
- Place of Presentation
  ソルトレイクシティ(アメリカ)
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-19700407
[Presentation] Molecular Design of Thermoresponsive Polymeric Micelles with Surface pH-Responsive Sulfonamide Moieties2009
- Author(s)
  Masamichi Nakayama, Yayoi Kawahara, Hideko Kanazawa, Teruo Okano
- Organizer
  14th International Symposium on Recent Advances in Drug Delivery Systems
- Place of Presentation
  ソルトレイクシティ(USA)
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-19700407
[Presentation] Surface Functionalization and Characterization of Thermoresponsive Polymeric Micelles2007
- Author(s)
  Masamichi Nakayama, Jun Akimoto, Kiyotaka Sakai, Teruo Okano
- Organizer
  1st Asian Biomaterials Congress
- Place of Presentation
  茨城県つくば市
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19700407
[Presentation] Nano-scale Physical Surface Coating of Temperature-responsive Polymers for Cell Sheet Fabrication
- Author(s)
  Masamichi Nakayama, Yurika Kimura, Hideko Kanazawa, Masayuki Yamato, Teruo Okano
- Organizer
  25th 2014 International Symposium on Micro-NanoMechatronics and Human Science
- Place of Presentation
  Noyori Conference Hall, Nagoya University (Nagoya)
- Year and Date
  2014-11-09 – 2014-11-12
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] End-functional poly(N-isopropylacrylamide) brushes for efficiently promoting cell adhesion and detachment
- Author(s)
  Nakayama Masamichi, Kanno Tomonori, Kikuchi Akihiko, Okano Teruo
- Organizer
  Society For Biomaterials 2014 Annual Meeting & Exposition
- Place of Presentation
  Denver, USA
- Year and Date
  2014-04-16 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-25282145
[Presentation] 表面フェニルボロン酸基の特性を利用した温度応答性高分子ミセルの相転移制御
- Author(s)
  中山正道、秋元淳、岡野光夫
- Organizer
  第63回高分子討論会
- Place of Presentation
  長崎大学（長崎県長崎市）
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] 細胞培養基材表面への温度応答性ブロック共重合体コーティングによる細胞シートの作製技術
- Author(s)
  中山正道、木村友梨香、豊島侑樹、金澤秀子、菊池明彦、大和雅之、岡野光夫
- Organizer
  第63回高分子討論会
- Place of Presentation
  長崎大学（長崎県長崎市）
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Nano-scale Surface Coating of Thermoresponsive Block Copolymers for Thermally Regulating Cell Adhesion/Detachment Behavior
- Author(s)
  Nakayama Masamichi, Kimura Yurika, Yamada Naoko, Kanazawa Hideko, Okano Teruo
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25282145

1. SHODA Junichi (90241827)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. YAMAMOTO Masakazu (60220498)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. ARIIZUMI Syunnichi (40277158)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. AKIYAMA Yoshikatsu (20349640)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. NAGASE Kenichi (10439838)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OHASHI Ohashi (40364062)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MIZUGUCHI Hiroyuki (50311387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. UTSUNOMIYA Hirohuto (60264876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TATSUMI Kohei (70555432)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. IWATA Hiroo (30160120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TAKEUCHI Kaoru (00192162)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. YAMATO MASAYUKI (40267117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
13. KOBAYASHI Jun (20385404)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. SHIMIZU Tatsuya (40318100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
15. YANAGAWA Toru (10312852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
16. AKIMOTO Jun (80649682)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
17. HARAGUCHI Yuji (80272251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. KIKUCHI Akihiko (40266820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
19. 増田信奈子 (30342851)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. TAKAHAHI Hironobu (00710039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIMIZU Tatsuya (70468867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. ISHIGE Kazunori (20597918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. KAWAKAMI Koji (70422318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. SUGIMOTO Mitsuhiko (80192128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. IWASE YUKO (80406371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. GOTO NAOHIRO (60323854)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. WARABI EIJI (70396612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
28. OKANO Teruo (00130237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 串田愛 (10338981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 山岡哲二 (50243126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 関根秀一 (60541737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KANNO Tomonori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
33. TOYOSHIMA Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. 高橋宏信

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
35. 三善英知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

nakayama masamichi 中山 正道

Nakayama Masamichi 中山 正道

NAKAYAMA Masamichi 中山 正道

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高度な細胞接着制御を実現する機能性高分子ナノコート界面の創製Principal Investigator

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Development of innovative human tumor models using cell patch method for high-speed three-dimensional organizationPrincipal Investigator

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Photo-controlled surface water repellency for smart cell separation systemPrincipal Investigator

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Cancer cell sheet tissue engineering for development of innovative three-dimensional cancer tissue modelsPrincipal Investigator

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Creation of thermoresponsive nano-phase separated surfaces for cell adhesion and detachmentPrincipal Investigator

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Newly molecular design of outermost surface functionalized thermoresponsive nano-micelles for drug carrier systemsPrincipal Investigator

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nakayama masamichi 中山正道

Nakayama Masamichi 中山正道

NAKAYAMA Masamichi 中山正道

[Book] DDS研究30年　温故知新2015