Tsuzuki Shinobu 都築忍

… Alternative Names

TSUZUKI Shinobu 都築忍

都筑忍

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Researcher Number	00342965
Other IDs
Affiliation (Current)	2023: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 愛知医科大学, 医学部, 教授 2015: 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 2011 – 2012: 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 2010: 愛知県がんセンター(研究所), 遺伝子診療研究部, 室長 2005 – 2009: 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 … More 2004: Aichi Cancer Center, Division of Molecular Medicine, Senior Researcher, 遺伝子医療研究部, 主任研究員 2003: Aichi Cancer Center, Molecular Medicine, Princpal Investigator, 遺伝子医療研究部, 主任研究員 2002 – 2003: 愛知県がんセンター, 遺伝子医療研究部, 主任研究員 Less
Review Section/Research Field	Principal Investigator Hematology / Basic Section 49030:Experimental pathology-related / Biological Sciences Except Principal Investigator Biological Sciences / Hematology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator TEL-AML1 / アレイCGH / 小児白血病 / アイソフォーム / GATA-2 / 白血病 / マウスモデル / siRNA / ライブラリー / 造血幹細胞 … More / 臍帯血 / AML1 / 前白血病 / 白血病性幹細胞 / レチノイン酸受容体 / プロB細胞 / retinoic acid receptor / leukemia / pro-B cells / ETV6-RUNX1 / array-CGH / genomic imbalances / second hits / leukemogenesis / mouse model / retrovirus / childhood leukemia / array-based CGH / isoform / 悪性リンパ腫 / レトロウイルス / 遺伝子導入 / 遺伝子変異 / CARD11 / BCL6 / 急性リンパ性白血病 / MEF2D / CRLF2 / 融合遺伝子 / クロマチン免疫沈降 / 転写因子ネットワーク / 多段階発癌 / B細胞 / 急性リンパ性 / ドライバー … More Except Principal Investigator MALT1 / API2-MALT1 / MALTリンパ腫 / API2 / Tissue-FISH / マントル細胞リンパ腫 / びまん性大細胞型B細胞リンパ腫 / NK / T白血病・リンパ / BIM / TNFAIP3 / アレイCGH / ゲノム異常 / 6q欠失 / AP12-MALT / CD40ligand / B細胞 / 長期培養 / BIM遺伝子 / NOXA / BCL2 / DLBCL / MCL / T白血病・リンパ腫 / CCND3 / BYSL / c-REL / BCL11A / 悪性リンパ腫 / T細胞性リンパ腫 / 染色体転座 / ゲノム / 転座関連遺伝子 / T細胞リンパ腫 / T / NKリンパ腫 / Lymphoma / T-cell lymphoma / MALT Lymphoma / Ebf3 / shRNA / ノックダウン / 脂肪細胞分化 / 骨髄造血微小環境 / 間葉系幹細胞 / メタボローム解析 Less

隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明Principal Investigator
- Principal Investigator
  
  都築忍
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Aichi Medical University
脂肪組織由来間葉系幹細胞-造血幹細胞における代謝経路解析：抗加齢作用に注目して
- Principal Investigator
  
  中山享之
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Aichi Medical University
Deciphering leukemia development and maintenance from the perspective of functions of fusion genesPrincipal Investigator
- Principal Investigator
  
  Tsuzuki Shinobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Aichi Medical University
Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model systemPrincipal Investigator
- Principal Investigator
  
  Tsuzuki Shinobu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Medical University
  Aichi Cancer Center Research Institute
Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemiaPrincipal Investigator
- Principal Investigator
  
  TSUZUKI Shinobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center Research Institute
Modeling human leukemia/lymphoma, and ex vivo expansion of hematopoietic stem cells and granulocytesPrincipal Investigator
- Principal Investigator
  
  TSUZUKI Shinobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center Research Institute
siRNA/がん遺伝子デュアル発現システムによる新規発がん機構の解明Principal Investigator
- Principal Investigator
  
  都築忍
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
Molecular mechanisms of lymphomagenesis
- Principal Investigator
  
  SETO Masao
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of multi-step processes of leukemia-genesis in childhood leukemia.Principal Investigator
- Principal Investigator
  
  TSUZUKI Shinobu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center Research Institute
Roles of GATA-2/retinoic acid receptor pathways and TEL-AML1 translocation in leukemiaPrincipal Investigator
- Principal Investigator
  
  TSUZUKI Shinobu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center
Roles of translocation junction genes for proliferation and differentiation of hemotolymphoid cell
- Principal Investigator
  
  SETO Masao
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Aichi Cancer Center

[Journal Article] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2020
- Author(s)
  Shinobu Tsuzuki, Takahiko Yasuda, Shinya Kojima, Masahito Kawazu, Koshi Akahane, Takeshi Inukai, Masue Imaizumi, Takanobu Morishita, Masashi Sanada,　Hideki Muramatsu, Yoshiyuki Takahashi, Yasushi Miyazaki, Itaru Matsumura, Hitoshi Kiyoi, Yoshitaka Hosokawa, Hiroyuki Mano, Fumihiko Hayakawa
- Journal Title
  
  Blood Cancer Discovery
  
  Volume: 1 Pages: 82-95
- DOI
  10.1158/2643-3230.bcd-19-0080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02645
[Journal Article] Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity2019
- Author(s)
  Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H.
- Journal Title
  
  Oncogene.
  
  Volume: 38 Pages: 2263-2274
- DOI
  10.1038/s41388-018-0573-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09921, KAKENHI-PROJECT-18K16103, KAKENHI-PROJECT-18H02645, KAKENHI-PROJECT-18H02835
[Journal Article] B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia2016
- Author(s)
  Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Pages: 4723-31
- DOI
  10.1074/jbc.m115.637835
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09472, KAKENHI-PROJECT-15K09492, KAKENHI-PROJECT-25293218
[Journal Article] STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas.2015
- Author(s)
  Yoshida N, Tsuzuki S, Karube K, Takahara T, Suguro M, Miyoshi H, Nishikori M, Shimoyama M, Tsukasaki K, Ohshima K, Seto M.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Pages: 1455-1462
- DOI
  10.1111/cas.12742
- NAID
  120005767013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09474, KAKENHI-PROJECT-15K09492
[Journal Article] TEL0ETV6)・AML1(RUNxl) Initiates Self-renewing Fetal Pro-B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice2013
- Author(s)
  Tsuzuki S and Seto M.
- Journal Title
  
  Stem Cells
  
  Volume: 31 Pages: 236-247
- DOI
  10.1002/stem.1277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591054, KAKENHI-PROJECT-24390249
[Journal Article] Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML12012
- Author(s)
  Tsuzuki S and Seto M.
- Journal Title
  
  Blood
  
  Volume: 119(3) Pages: 727-735
- DOI
  10.1182/blood-2011-06-362277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591054, KAKENHI-PROJECT-24390249
[Journal Article] Promotion and maintenance of leukemia by ERG2011
- Author(s)
  Tsuzuki S
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 3858-3868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591054
[Journal Article] Promotion and maintenance of leukemia by ERG.2011
- Author(s)
  Tsuzuki S, Taguchi O, Seto M.
- Journal Title
  
  Blood.
  
  Volume: 117(14) Pages: 3858-3868
- DOI
  10.1182/blood-2010-11-320515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591054
[Journal Article] TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas.2009
- Author(s)
  Honma, K, Tsuzuki, S. Seto, M., 他4名, Last Author
- Journal Title
  
  Blood 114
  
  Pages: 2467-2475
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] TNFAIP3 is the target gene of chromosome band 6q23. 3-q24. 1 loss in cular. Adnexal marginal zone B cell lymphoma.2008
- Author(s)
  Honma, K., Tsuzuki, S., Nakagawa, M., Seto, M., 他6名, Last Author
- Journal Title
  
  Genes Chrom. Cancer 47
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1.2007
- Author(s)
  Tsuzuki S
- Journal Title
  
  PLoS Med. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591149
[Journal Article] Isoform-specific potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX12007
- Author(s)
  Tsuzuki S
- Journal Title
  
  Plos Medicine (印刷中)
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Isoform-specific potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX12007
- Author(s)
  Tsuzuki S, Hong D, Rajeev G, Matsuo K, Seto M, Enver T
- Journal Title
  
  Plos Medicine (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AMLl acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization2007
- Author(s)
  Tsuzuki S, Karnan S, Horibe K, Matsumoto K, Kato K, Inukai T, Goi K, Sugita K, Nakazawa S, Kasugai Y, Ueda R, Seto M
- Journal Title
  
  Cancer Science
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development.2007
- Author(s)
  Tagawa, H., Karube, K., Tsuzuki, S., Ohshima, K., Seto, M.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 1482-1490
- NAID
  10019999091
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1.2007
- Author(s)
  Tsuzuki, S., Hong, D., Gupta, R., Matsuo, K., Seto, M., Enver, T.
- Journal Title
  
  PLoS Med. 4
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Genetic abormalities involved om t(12:21) TEL-AML1 acute lymphoblastic leukemia: analysis by means of array-based comparative genomic hybridization.2007
- Author(s)
  Tsuzuki S.
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 698-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012056
[Journal Article] Isoform- Specific Potentiation of Stem and Progellitor Cell Engraftment by AMLl1RUNX1.2007
- Author(s)
  Tsuzuki, S.
- Journal Title
  
  PLoS Med. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: Analysis by means of array-based comparative genomic hybridization.2007
- Author(s)
  Tsuzuki, S., Karnan, S., Seto, M., 他9名, Last Author
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 698-706
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia- Analysis by means of array-based comparative genomic hybridization2007
- Author(s)
  Tsuzuki S, 12名
- Journal Title
  
  Cancer Science 98
  
  Pages: 698-706
- Data Source
  KAKENHI-PROJECT-19591149
[Journal Article] Genetic abnormalities involved in t(12;2l) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization2007
- Author(s)
  Tsuzuki S, Karnan S, Horibe K, Matsumoto K, Kato K, Inukai T, Goi K, Sugita K, Nakazawa S, Kasugai Y, Ueda R, Seto M
- Journal Title
  
  Cancer Science (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Genetic abnormalities involved in t(12;21)TEL-AM-L1 acute lymphoblastic leukemia:Analysis by means of array-based comparative genomic hybridization.2007
- Author(s)
  Tsuzuki, S
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 698-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Tsuzuki S, 6名 ^Isoform-specific potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX12007
- Author(s)
  Tsuzuki S, 6名
- Journal Title
  
  Plos Medicine 4
- Data Source
  KAKENHI-PROJECT-19591149
[Journal Article] Isform-soecufic potentiation of stem and progenitor cell engraftment by AMl1/Runx1.2007
- Author(s)
  Tsuzuki S.
- Journal Title
  
  PLoS Med. 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012056
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization2007
- Author(s)
  Tsuzuki S
- Journal Title
  
  Cancer Science (印刷中)
- Data Source
  KAKENHI-PROJECT-18012056
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization2007
- Author(s)
  Tsuzuki S
- Journal Title
  
  Cancer Science (印刷中)
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia:analysis by means of array-based comparative genomic hybridization.2007
- Author(s)
  Tsuzuki S
- Journal Title
  
  Cancer Sci. 98
  
  Pages: 698-706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591149
[Journal Article] Isoform-specific potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX12007
- Author(s)
  Tsuzuki S
- Journal Title
  
  Plos Medicine (印刷中)
- Data Source
  KAKENHI-PROJECT-18012056
[Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.2006
- Author(s)
  Karnan, S., Tsuzuki, S., Seto, M., 他4名, 6番目
- Journal Title
  
  Genes Chrom. Cancer 45
  
  Pages: 420-425
- Data Source
  KAKENHI-PROJECT-17015050
[Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.2006
- Author(s)
  Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T
- Journal Title
  
  Genes Chromosomes Cancer. 45
  
  Pages: 420-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma.2005
- Author(s)
  Tagawa H, Suguro M, Tsuzuki S, Matsuo K, Karnan S, Oshima K, Okamoto M, Morishima Y, Nakamura S, Seto M
- Journal Title
  
  Blood 106
  
  Pages: 1770-1777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL1O.2005
- Author(s)
  Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, Asaka M, Seto M
- Journal Title
  
  Blood 106
  
  Pages: 4210-4216
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Developmental impact of leukemic fusion genes on stem cell fate.2005
- Author(s)
  Enver T, Tsuzuki S, Brown J, Hong D, Gupta R, Ford T, Egucchi MI, Egucchi M, Greaves M.
- Journal Title
  
  Ann N Y Acad Sci. 1044
  
  Pages: 16-23
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Developmental impact of leukemic fusion genes on stem cell fate.2005
- Author(s)
  Eriver T, Tsuzuki S, Greaves M
- Journal Title
  
  Ann N Y Acad Sci. 1044
  
  Pages: 16-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10.2005
- Author(s)
  Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, Asaka M, Seto M
- Journal Title
  
  Blood 106
  
  Pages: 4210-4216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Developmental impact of leukemia fusion genes on stem cell fate.2005
- Author(s)
  Enver T, Tsuzuki S, Greaves M
- Journal Title
  
  Ann N Y Acad Sci. 1044
  
  Pages: 16-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma.2005
- Author(s)
  Tagawa H, Suguro M, Tsuzuki S, Matsuo K, Karnan S, Ohshima K, Okamoto M, Morishima Y, Nakamura S, Seto M.
- Journal Title
  
  Blood. 106
  
  Pages: 1770-1777
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10.2005
- Author(s)
  Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, Asaka M, Seto M.
- Journal Title
  
  Blood. 106
  
  Pages: 4210-4216
- Data Source
  KAKENHI-PROJECT-17591024
[Journal Article] Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.2004
- Author(s)
  Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M.
- Journal Title
  
  Cancer Res. 64(9)
  
  Pages: 3087-3095
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma.2004
- Author(s)
  Kameoka Y, Tagawa H, Tsuzuki S, Karnan S, Ota A, Suguro M, Suzuki R, Yamaguchi M, Morishima Y, Nakamura S, Seto M.
- Journal Title
  
  Oncogene 23(56)
  
  Pages: 9148-9154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Identification and characterization of a novel gene, C13orf25,as a target for 13q31-q32 amplification in malignant lymphoma.2004
- Author(s)
  Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M.
- Journal Title
  
  Cancer Res. 64(9)
  
  Pages: 3087-3095
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Identification and characterization of a novel gene, C13orf25, as target 13q31-q32 amplification in malignant lymphoma.2004
- Author(s)
  Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M.
- Journal Title
  
  Cancer Res. 64(9)
  
  Pages: 3087-3095
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Modeling‘first hit' functions of the t(12;21) TEL-AML1 translocation in mice.2004
- Author(s)
  Tsuzuki S, Seto M, Greaves M, Enver T
- Journal Title
  
  Proc Natl Acad Sci U S A. 101(22)
  
  Pages: 8443-8448
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma : comparison between CD5-positive and CD5-negative cases.2004
- Author(s)
  Tagawa H, Tsuzuki S, Suzuki R, Karnan S, Ota A, Kameoka Y, Suguro M, Matsuo K, Yamaguchi M, Okamoto M, Morishima Y, Nakamura S, Seto M.
- Journal Title
  
  Cancer Res. 64(17)
  
  Pages: 5948-5955
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Crosstalk between retinoic acid signaling and transcription factor GATA-2.2004
- Author(s)
  Tsuzuki S, Kitajima K, Nakano T, Glasow A, Zelent A, Enver T
- Journal Title
  
  Mol Cell Biol. 24(15)
  
  Pages: 6824-6836
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Modeling ‘first hit' functions of the t(12;21) TEL-AML1 translocation in mice.2004
- Author(s)
  Tsuzuki S, Seto M, Greaves M, Enver T
- Journal Title
  
  Proc Natl Acad Sci USA. 101(22)
  
  Pages: 8443-8448
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Modeling ‘first hit' functions of the t(12;21) TEL-AML1 translocation in mice.2004
- Author(s)
  Tsuzuki S, Seto M, Greaves M, Enver T
- Journal Title
  
  Proc Natl Acad Sci U S A. 101(22)
  
  Pages: 8443-8448
- Data Source
  KAKENHI-PROJECT-15591037
[Journal Article] Isoform-specific potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1
- Author(s)
  Tsuzuki S, Hong D, Rajeev G, Matsuo K, Seto M, Enver T
- Journal Title
  
  Plos Medicine (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591024
[Patent] MEF2D融合型急性リンパ性白血病を治療するための医薬組成物2020
- Inventor(s)
  都築　忍
- Industrial Property Rights Holder
  都築　忍
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-020730
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18H02645
[Patent] MEF2D融合型急性リンパ性白血病を治療するための医薬組成物2020
- Inventor(s)
  都築　忍
- Industrial Property Rights Holder
  都築　忍
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-020729
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18H02645
[Presentation] ZNF384融合遺伝子による急性リンパ性白血病発症機構の解明2018
- Author(s)
  山本秀行、早川文彦、安田貴彦、南川友香、丹下直幸、平野大希、小島勇貴、都築　忍、間野博行、直江知樹、清井仁
- Organizer
  第80回　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02645
[Presentation] 成人B細胞性急性リンパ性白血病のゲノム学的・臨床的な特徴2018
- Author(s)
  安田貴彦、西島大、小島進也、河津正人、上野俊秀、都築忍、清井仁、松村到、宮崎泰司、堀部敬三、間野博行、直江知樹、真田昌、早川文彦
- Organizer
  第80回　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02645
[Presentation] The rs3779620 in the PBK gene is closely associated with myeloma cell growth2017
- Author(s)
  Ota Akinobu, Karnan Sivasundaram, Md Wahiduzzaman, Mizuno Shohei, Uchino Kaori, Kanasugi Jo, Horio Tomohiro, Murakami Satsuki, Suzuki Susumu, Tsuzuki Shinobu, Konishi Hiroyuki, Ueda Ryuzo, Hosokawa Yoshitaka, Takami Akiyoshi
- Organizer
  第79会　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09492
[Presentation] High expression of MEF2D-fusion protein by escaping from the regulation by microRNA2017
- Author(s)
  Hirano Daiki, Hayakawa Fumihiko, Yasuda Takahiko, Yamamoto Hideyuki, Kojima Yuki, Morishita Takanobu, Imoto Naoto, Tsuzuki Shinobu, Mano Hiroyuki, Naoe Tomoki, Kiyoi Hitoshi
- Organizer
  第79会　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09492
[Presentation] Synergistic activity of Card11 mutant and Bcl6 genes in the development of diffuse large B cell lymphoma in a mouse model2016
- Author(s)
  高原大志　中村栄男　松尾恵太朗　瀬戸正夫　都築忍
- Organizer
  Korean-Japanese Lymphoreticular Workshop 2016
- Place of Presentation
  MAYFIELD Hotel(韓国　ソウル市)
- Year and Date
  2016-01-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09492
[Presentation] マウスモデルを用いたDiffuse large B cell lymphoma（DLBCL）関連遺伝子の機能解析2015
- Author(s)
  高原大志　都築忍
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K09492
[Presentation] Cooperation of altered AML1/RUNX1 with BCR-ABL in inducing blast crisis-like disease of chronic myelogenous leukemia.2012
- Author(s)
  都築忍
- Organizer
  第71回日本癌学会総会
- Place of Presentation
  ロイトン札幌(札幌)
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-22591054
[Presentation] Altered differentiation and enhanced self-renewal activity of B cells by the leukemia-associated TEL (ETV6)-AML1 (RUNX1) fusion gene2011
- Author(s)
  都築忍
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22591054
[Presentation] Altered differentiation and enhanced self-renewal activity of B cells by the leukemia-associated TEL(ETV6)-AML1(RUNX1) fusion gene2011
- Author(s)
  Shinobu Tsuzuki
- Organizer
  第70回2011 日本癌学会学術集会シンポジウム(International Symposium: Dysregulated differentiation program in cancer)
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22591054
[Presentation] ERG発現による白血病化2010
- Author(s)
  都築忍
- Organizer
  第6回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22591054
[Presentation] ERG発現による白血病化2010
- Author(s)
  都築忍
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22591054
[Presentation] 急性リンパ性白血病の前白血病期におけるTEL-AML1の役割.2009
- Author(s)
  都築忍
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-17015050
[Presentation] TEL-AML1白血病におけるTEL欠失の作用2008
- Author(s)
  都築忍
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19591149
[Presentation] TEL-AML1白血病におけるTEL欠失の作用2008
- Author(s)
  都築忍
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19591149
[Presentation] TEL-AML1自血病におけるTEL欠失の作用.(ポスター)2008
- Author(s)
  都築忍
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17015050
[Presentation] t(12;21)染色体転座により形成されるTEL・AMLI合遺伝子の機能解析2007
- Author(s)
  都築忍
- Organizer
  第66回日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18012056
[Presentation] t(12;21)染色体転座により形成されるTEL-AML1融合遺伝子の機能解析2007
- Author(s)
  都築忍
- Organizer
  第回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19591149

1. SETO Masao (80154665)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 安田貴彦 (20723977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 中山享之 (00456659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NISHIKORI Momoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 清井仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 早川文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 直江知樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuzuki Shinobu 都築 忍

TSUZUKI Shinobu 都築 忍

都筑 忍

Research Projects

Research Products

Co-Researchers

隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明Principal Investigator

Principal Investigator

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Research Institution

脂肪組織由来間葉系幹細胞-造血幹細胞における代謝経路解析：抗加齢作用に注目して

Principal Investigator

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Research Institution

Deciphering leukemia development and maintenance from the perspective of functions of fusion genesPrincipal Investigator

Principal Investigator

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Review Section

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Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model systemPrincipal Investigator

Principal Investigator

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Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemiaPrincipal Investigator

Principal Investigator

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Modeling human leukemia/lymphoma, and ex vivo expansion of hematopoietic stem cells and granulocytesPrincipal Investigator

Principal Investigator

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siRNA/がん遺伝子デュアル発現システムによる新規発がん機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Molecular mechanisms of lymphomagenesis

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Analysis of multi-step processes of leukemia-genesis in childhood leukemia.Principal Investigator

Principal Investigator

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Roles of GATA-2/retinoic acid receptor pathways and TEL-AML1 translocation in leukemiaPrincipal Investigator

Principal Investigator

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Research Institution

Roles of translocation junction genes for proliferation and differentiation of hemotolymphoid cell

Principal Investigator

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[Journal Article] Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity2019

Author(s)

Journal Title

Tsuzuki Shinobu 都築忍

TSUZUKI Shinobu 都築忍

都筑忍