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Morimura Naoko  守村 直子

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MORIMURA Naoko  守村 直子

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Researcher Number 00349044
Other IDs
Affiliation (Current) 2025: 滋賀医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2022 – 2023: 滋賀医科大学, 医学部, 助教
2016 – 2021: 滋賀医科大学, 医学部, 特任助教
2015: 立命館大学, 総合科学技術研究機構, 研究員
2005: Riken, Brain Science Institute, Researcher, 脳科学総合研究センター, 研究員
2004 – 2005: 独立行政法人理化学研究所, 比較神経発生研究チーム, 研究員 … More
2004: 理化学研究所, 脳科学研究センター・比較神経発生チーム, 研究員
2003: 昭和大学, 歯学部・口腔生化学教室, 助手
2002 – 2003: Showa University School of Dentistry Research Associate, 歯学部, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 46010:Neuroscience-general-related / Neurochemistry/Neuropharmacology / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Morphological basic dentistry / Functional basic dentistry
Keywords
Principal Investigator
シナプス接着分子 / 非ヒト霊長類 / シナプス形成 / グリオーマ / 発達障害 / シナプス可塑性 / 神経発達障害 / シナプスオーガナイザー / 統合失調症 / 自閉症 … More / 可塑性 / 興奮性シナプス / 骨芽細胞 / CD44 / インテグリン / 細胞接着分子 … More
Except Principal Investigator
RANKL / インターロイキン-1 / ATDC5 / SST-REX method / Notch / 骨芽細胞 / 骨形成 / radicals / NADPH-oxidase / osteoarthritis / rheumatoid arthritis / cell death / synoviocytes / chondrocytes / nitric oxide / ネクローシス / ミトコンドリア / パーオキシナイトライト / スーパーオキサイド / 軟骨 / 生理活性 / 生体分子 / ストレス / シグナル伝達 / 細胞・組織 / ラジカル / NADPH-oxdiase / 変形性関節症 / 関節リウマチ / 細胞死 / 滑膜細胞 / 軟骨細胞 / 一酸化窒素 / Periodontal disease / Long bone / Bone mineral density / Bone resorption / alveolar bone / transgenic mice / Interleukin 1 / LPS / OPG / トランスジェニックマウス / ドライスカル / 口腔内細菌 / サイトカイン / トランスジェニック / 破骨細胞 / 歯根膜 / 歯周病 / 低カルシウム / 副甲状腺ホルモン / 骨吸収 / 歯槽骨 / Ossification / Chondrogenesis / Limb bud micromass culture / 軟骨基質 / Notch1 / Conditional deletion mutantマウス / 転写因子 / 遺伝子発現 / 内軟骨性骨化 / 細胞凝集 / 間葉系幹細胞 / マウス肢芽 / DAPT / Limb Bud Micromass Culture / 軟骨形成 / Limb bud micro-mass culture / CELL DIFFERENTIATION / MYOBLAST / OSTEOBLAST / BONE MORPHOGENETIC PROTEIN / GROWTH FACTOR / HORMONE / TRANSCRIPTION FACTOR / BONE FORMATION / 受容体 / 血清 / 転写調節因子 / 筋芽細胞 / 細胞分化 / 骨誘導因子 / 成長因子 / ホルモン Less
  • Research Projects

    (8 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (25 People)
  •  Molecular mechanism underlying synapse development between neurons and glioma cellsPrincipal Investigator

    • Principal Investigator
      守村 直子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Shiga University of Medical Science
  •  Molecular Mechanisms of Neurodevelopmental Disorders mediated by the Synapse Adhesion Molecule LRFN2Principal Investigator

    • Principal Investigator
      MORIMURA NAOKO
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      Shiga University of Medical Science
  •  Molecular function of a synaptic adhesion molecule, SALM/Lrfn in the brain.Principal Investigator

    • Principal Investigator
      Morimura Naoko
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Shiga University of Medical Science
      Ritsumeikan University
  •  On the regulation of survival and death of synoviocytes and chondrocytes by nitric oxide

    • Principal Investigator
      MIYAMOTO Yoichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  細胞接着分子POEMを介した骨および歯胚形成の分子メカニズムの解明Principal Investigator

    • Principal Investigator
      守村 直子
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      The Institute of Physical and Chemical Research
      Showa University
  •  Studies on molecular mechanisms involved in differentiation of chondrocyte/osteoblast by Notch

    • Principal Investigator
      HOZUMI Nobumichi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Tokyo University of Science
  •  Mechanisms of bone resorption in alveolar bone of IL-1 transgenic mice

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nihon Pharmaceutical University
      Showa University
  •  CHARACTERIZATION OF THE BONE FORMING FACTORS IN SERUM

    • Principal Investigator
      KATAGIRI Takenobu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      SHOWA UNIVERSITY

All 2024 2023 2022 2021 2019 2018 2017 2003

All Journal Article Presentation

  • [Journal Article] Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina2022

    • Author(s)
      Abdullah Asmaa、Hayashi Yoshitaka、Morimura Naoko、Kumar Akhilesh、Ikenaka Kazuhiro、Togayachi Akira、Narimatsu Hisashi、Hitoshi Seiji
    • Journal Title

      Neurochemical Research

      Volume: 47 Issue: 9 Pages: 2793-2804

    • DOI

      10.1007/s11064-022-03651-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07758, KAKENHI-PROJECT-22K06429
  • [Journal Article] Lrtm2 controls protein sorting in the striatal projection system and its deficiency causes disturbances in motor responses and monoamine dynamics2022

    • Author(s)
      Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Jun Aruga
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: - Pages: 856315-856315

    • DOI

      10.3389/fnmol.2022.856315

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06905, KAKENHI-PROJECT-20K21605, KAKENHI-PROJECT-19H03327, KAKENHI-PROJECT-22K06429
  • [Journal Article] Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation2022

    • Author(s)
      Katayama Kei-ichi、Morimura Naoko、Kobayashi Katsunori、Corbett Danielle、Okamoto Takehito、Ornthanalai Veravej G.、Matsunaga Hayato、Fujita Wakako、Matsumoto Yoshifumi、Akagi Takumi、Hashikawa Tsutomu、Yamada Kazuyuki、Murphy Niall P.、Nagao Soichi、Aruga Jun
    • Journal Title

      iScience

      Volume: 25 Issue: 7 Pages: 104604-104604

    • DOI

      10.1016/j.isci.2022.104604

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07275, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-23K23985
  • [Journal Article] Conformational change of RNA-helicase DHX30 by ALS/FTD-linked FUS induces mitochondrial dysfunction and cytosolic aggregates2022

    • Author(s)
      Hikiami R, Morimura T, Ayaki T, Tsukiyama T, Morimura N, Kusui M, Wada H, Minamiyama S, Shodai A, Asada-Utsugi M, Muramatsu SI, Ueki T, Takahashi R, Urushitani M.
    • Journal Title

      Scxeintific Reports

      Volume: 12 Issue: 1 Pages: 16030-16046

    • DOI

      10.1038/s41598-022-20405-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06391, KAKENHI-PROJECT-22K06429, KAKENHI-PROJECT-22K19246, KAKENHI-ORGANIZER-20H05760, KAKENHI-PLANNED-20H05763, KAKENHI-PROJECT-19K16277, KAKENHI-PROJECT-23K23794, KAKENHI-PROJECT-23K24211
  • [Journal Article] Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG2021

    • Author(s)
      Oura Seiya、Noda Taichi、Morimura Naoko、Hitoshi Seiji、Nishimasu Hiroshi、Nagai Yoshitaka、Nureki Osamu、Ikawa Masahito
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-021-02304-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06905, KAKENHI-PLANNED-19H05750, KAKENHI-PROJECT-21H04753, KAKENHI-PROJECT-20H03172, KAKENHI-PROJECT-19J21619, KAKENHI-PLANNED-20H05927
  • [Journal Article] FGF-2 suppresses expression of nephronectin via JNK and PI3K pathways2018

    • Author(s)
      Kato Tadashi、Yamada Atsushi、Ikehata Mikiko、Yoshida Yuko、Sasa Kiyohito、Morimura Naoko、Sakashita Akiko、Iijima Takehiko、Chikazu Daichi、Ogata Hiroaki、Kamijo Ryutaro
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 5 Pages: 836-842

    • DOI

      10.1002/2211-5463.12421

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09737, KAKENHI-PROJECT-18K19655, KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-16K15782
  • [Journal Article] Nephronectin Expression is Inhibited by Inorganic Phosphate in Osteoblasts2018

    • Author(s)
      Kato Tadashi、Yamada Atsushi、Sasa Kiyohito、Yoshimura Kentaro、Morimura Naoko、Ogata Hiroaki、Sakashita Akiko、Kamijo Ryutaro
    • Journal Title

      Calcified Tissue International

      Volume: 104 Issue: 2 Pages: 201-206

    • DOI

      10.1007/s00223-018-0484-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09737, KAKENHI-PROJECT-18K09512, KAKENHI-PROJECT-18K09528, KAKENHI-PROJECT-18K19655, KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-15K11051, KAKENHI-PROJECT-16K15782
  • [Journal Article] Wnt/β-catenin signaling activates nephronectin expression in osteoblasts.2017

    • Author(s)
      Ikehata M, Yamada A, Morimura N, Itose M, Suzawa T, Shirota T, Chikazu D, Kamijo R
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 484 Issue: 2 Pages: 231-234

    • DOI

      10.1016/j.bbrc.2017.01.053

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05016, KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-15K11051, KAKENHI-PROJECT-16K15782
  • [Journal Article] IL-1β suppresses nephronectin expression in osteoblasts via ERK1/2 and JNK2017

    • Author(s)
      Iezumi Yuka、Yamada Atsushi、Minami Erika、Ikehata Mikiko、Yoshida Yuko、Kato Tadashi、Morimura Naoko、Ogata Hiroaki、Sakashita Akiko、Iijima Takehiko、Chikazu Daichi、Kamijo Ryutaro
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 493 Issue: 1 Pages: 773-775

    • DOI

      10.1016/j.bbrc.2017.08.104

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-15K11051, KAKENHI-PROJECT-16K15782, KAKENHI-PROJECT-15H05016
  • [Journal Article] Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice2017

    • Author(s)
      Morimura Naoko、Yasuda Hiroki、Yamaguchi Kazuhiko、Katayama Kei-ichi、Hatayama Minoru、Tomioka Naoko H.、Odagawa Maya、Kamiya Akiko、Iwayama Yoshimi、Maekawa Motoko、Nakamura Kazuhiko、Matsuzaki Hideo、Tsujii Masatsugu、Yamada Kazuyuki、Yoshikawa Takeo、Aruga Jun
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 15800-15800

    • DOI

      10.1038/ncomms15800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K06789, KAKENHI-PROJECT-17K01982, KAKENHI-PROJECT-16K18878, KAKENHI-PROJECT-15H04889, KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-26430003, KAKENHI-PROJECT-26590161, KAKENHI-PROJECT-15K09814
  • [Journal Article] Suppression of differentiation and proliferation of early chondrogenic cells by Notch.2003

    • Author(s)
      Watanabe, N., Tezuka, Y., Matsuno, K., Miyatani, S., Morimura, N., Yasuda, M., Fujimaki, R., Kuroda, K., Hiraki, Y., Hozumi, N., Tezuka, K.
    • Journal Title

      J.Bone Miner.Metab. 21

      Pages: 344-352

    • NAID

      10014445248

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390557
  • [Presentation] Functional role of a synaptic adhesion-like molecule, LRFN2, in gliomagenesis.2024

    • Author(s)
      Takuma Yoshizawa, Kenny Anak Daun, Tadateru Fukami, Naoko Morimura, Seiji Hitoshi
    • Organizer
      第101回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-22K06429
  • [Presentation] Expression and malignant role of an extracellular matrix integrin a8b1 ligand, POEM/NPNT in glioblastoma.2023

    • Author(s)
      Naoko Morimura, Kenny Anak Daun, Yui Igarashi, Tadateru Fukami, Seiji Hitoshi
    • Organizer
      ISN-ESN2023
    • Data Source
      KAKENHI-PROJECT-22K06429
  • [Presentation] POEM/NPNTはグリオブラストーマの新規悪性化因子である2023

    • Author(s)
      五十嵐唯, Kenny Daun, 深見忠輝, 山田篤, 上條竜太郎, 等誠司, 守村直子
    • Organizer
      第46回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-22K06429
  • [Presentation] Kruppel-like factors 4 and 5 have opposing effects on the determination of neural precursor cell fate in the developing mammalian brain.2023

    • Author(s)
      Seiji Hitoshi, Takahiro Fuchigami, Yoshitaka Hayashi, Zakiyyah MM Zaki, Anri Kuroda, Naoko Morimura, Yasuhiro Go, Takuya Azami, Masatsugu Ema
    • Organizer
      ISN-ESN2023
    • Data Source
      KAKENHI-PROJECT-22K06429
  • [Presentation] グリオーマ幹細におけるエピゲノム因子 RNF20 の機析2022

    • Author(s)
      Kenny Daun, 守村直子(発表者), 深見忠輝, 谷垣健二, 椎野顯彦, 野崎和彦, 等誠司
    • Organizer
      第9回Neuro-Oncology West
    • Data Source
      KAKENHI-PROJECT-19K06905
  • [Presentation] RNF20 as an epigenetic regulator for GBM stem-like cells maintenance and regulation.2022

    • Author(s)
      Daun K, Morimura N, Fukami T, Hayashi Y, Koyama N, Tanigaki T, Shiino A, Nozaki K, Hitoshi S
    • Organizer
      第18回成体脳ニューロン新生懇談会
    • Data Source
      KAKENHI-PROJECT-19K06905
  • [Presentation] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.2019

    • Author(s)
      NAOKO MORIMURA, HIROKI YASUDA, KAZUHIKO YAMAGUCHI, KEI-ICHI KATAYAMA, NAOKO H. TOMIOKA, KAZUYUKI YAMADA, SEIJI HITOSHI, TAKEO YOSHIKAWA, JUN ARUGA.
    • Organizer
      The 10th IBRO World Congress of Neuroscience IBRO2019
    • Data Source
      KAKENHI-PROJECT-19K06905
  • [Presentation] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice2018

    • Author(s)
      Jun Aruga, Naoko Morimura, Hiroki Yasuda, Kei-ichi Katayama, Minoru Hatayama, Takeo Yoshikawa
    • Organizer
      第91回日本薬理学会年会 第18回国際薬理学・臨床薬理学会議
    • Data Source
      KAKENHI-PROJECT-15K06789
  • [Presentation] RNF20/BRE1a regulates proliferation and differentiation of GBM cancer stem-like cells2018

    • Author(s)
      Kenny Daun, Naoko Morimura, Toshihiro Yokoi, Kazuhiko Nozaki, Kenji Tanigaki, Seiji Hitoshi
    • Organizer
      15th Meeting of the Asian-Pacific Society For Neurochemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06789
  • [Presentation] シナプス接着分子Lrfn2/SALM1 から発達障害を考える. Lrfn2 遺伝子欠損マウスにみられた自閉症様行動と記憶機能およ びシナプス可塑性の向上2018

    • Author(s)
      守村 直子
    • Organizer
      第19回運動器科学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K06789
  • [Presentation] Autism-like behaviors and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice2017

    • Author(s)
      Morimura N., et al.
    • Organizer
      第60回日本神経化学会大会
    • Data Source
      KAKENHI-PROJECT-15K06789
  • [Presentation] 加齢マウスにおける不安行動の増大および海馬のシナプス分子の減少2017

    • Author(s)
      横川拓海, 守村直子, 他
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-15K06789
  • 1.  KAMIJO Ryutaro (70233939)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 2.  SHINKI Toshimasa (90138420)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  MIYAMOTO Youichi (20295132)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKAMI Masamichi (80307058)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KATAGIRI Takenobu (80245802)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  HOZUMI Nobumichi (60051744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  SUZUKI Mitsuhiro (00321662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SAKURADA Chikai (30279244)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KOBAYASHI Makoto (80186767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高橋 直之 (90119222)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  宇田川 信之 (70245801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  香山 雅子 (80318229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  赤池 孝章 (20231798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Aruga Jun
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  Mishina Masami
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Hitoshi Seiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  Yasuda Hiroki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 18.  Yoshikawa Takeo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  Yanaga Aki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  OGATA Hiroaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  HAMABE Wakako
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  林 義剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  山田 篤
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  漆谷 真
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  守村 敏史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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