KOBAYASHI Makoto 小林誠

… Alternative Names

小林誠コバヤシマコト

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Researcher Number	80186767
Affiliation (based on the past Project Information) *help	2003 – 2010: 昭和大学, 歯学部, 講師 1994 – 2000: 昭和大学, 歯学部, 講師 1998: Showa University,School of Dentistry lecturer, 医学部, 講師 1992: 昭和大学, 歯学部, 講師 1989 – 1990: 昭和大学, 歯学部・歯周治療学, 講師 1988: 昭和大学, 歯学部歯周治療学講座, 講師
Review Section/Research Field	Principal Investigator Conservative dentistry / Periodontal dentistry Except Principal Investigator Periodontal dentistry / Periodontal dentistry / Functional basic dentistry / Morphological basic dentistry / Conservative dentistry / 小児・社会系歯学
Keywords	Principal Investigator 歯根膜細胞 / 間葉系幹細胞 / 多分化能 / ICE / IL-1 / 腱・靭帯マーカー分子 / 培養ヒト歯根膜細胞 / 歯周組織再生 / Osteocalcin / Cyclic AMP … More / Alkaline phosphatase / Osteoblast / Periodontal ligament cell / 活性型ビタミンD_3 / アルカリフォスタァターゼ活性 / オステオカルシン / サイクリックAMP / アルカリフォスファタ-ゼ / 骨芽細胞 / potential of multi-lineage differentiation / mesenchymal stem cells / side population cells / periodontal ligament markers / ligament markers / tendon / periodontal ligament cells / 中胚葉系前駆細胞 / 幹細胞 / TGF-β3 / 軟骨分化誘導 / 骨髄間葉系幹細胞 / Side population細胞 / 歯根膜マーカー分子 / 腱・靱帯マーカー分子 / Multilineage Differentiation / Cell Surface Antigens / Mesenchymal Stem Cells / Human Periodontal Ligament Cells / Periodontal Regeneration / gene exression profile解析 / 細胞表層分子 / Caspase / apoptosis / gingival fibroblast / 線維芽細胞 / プロセッシング / IL-1Ra / IL-1β / IL-1α / 歯肉線維芽細胞 / caspase / アポトーシス / 歯肉線維に芽細胞 / Collagenase activity / Interleukin-1beta / Prostaglandin E_2 / Gingival Crevicular Fluid / Disease activity / Periodontitis / プロスタダランジンE_2 / 病変活動度 / 歯肉溝滲出液 / コラゲナーゼ活性 / インターロイキン-1β / プロスタグランディンE_2 / 歯周溝滲出液 / 疾病活動性 / 歯周炎 / Side Population 細胞 / ヒト歯根膜細胞 / 腱・靱帯マーカー / 組織幹細胞 / SP細胞 / decorin / biglycan / twist / BMPアンタゴニスト / 骨分化制御 / Side Population(SP)細胞 / ヒト歯根膜 … More Except Principal Investigator RANKL / 破骨細胞 / heterogeneity / BMP / 歯周病 / ヒトモノサイト / ヒト歯肉線維芽細胞 / Human Monocyte / Chemokine / Osteoclast / ケモカイン / Periodontal disease / Long bone / Bone mineral density / Bone resorption / alveolar bone / transgenic mice / Interleukin 1 / LPS / OPG / トランスジェニックマウス / ドライスカル / 口腔内細菌 / サイトカイン / トランスジェニック / 歯根膜 / 低カルシウム / 副甲状腺ホルモン / インターロイキン-1 / 骨吸収 / 歯槽骨 / cell function / Thy-1 antigen / Human gingival fibroblasts / IL-4 / IFN-γ / Thy-1 / 細胞機能 / Thy-1抗原 / osteoblast / Bone Formation / Bone regeneration / 再生 / 骨 / 骨芽細胞 / 骨形成 / 骨再生 / prostaglandin EィイD22ィエD2 production / intercellular 1L-1αproduction / cell growth / interleukin-1 / human gingibal fiibroblasto / c-fosgene / periodontitis / メタロプロテアーゼ / プロスタグランジンE_2 / 歯周病病態形成 / c-fos遺伝子発現 / メタロプロテアーゼ産生 / PGE_2産生 / c-fos / メタプロテアーゼ / プロスタグランディンE_2 / 細胞増殖 / C-fos / プロスタグランデン E_2産生 / 細胞画分IL-1α産生 / 細部増殖 / インターロイキンー1 / 歯肉線維芽細胞 / c-fos遺伝子 / 歯周炎 / 細胞内シグナル伝達機構 / リポポリサッカライド / インターフェロンγ / トゥーモルネクローシスファクターα / インターロイキン1β / 膜貫通型CD14 / 経年的観察 / パノラマX線写真 / 歯槽骨吸収 / 若年者 / 歯周疾患 Less

Investigation for establishment of periodontal regenerative therapy using stem cells in cultured periodontal ligament cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
Identification of the unknown periodontal ligament-related moleculesPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
A study of the role of chemokine in regulation of human osteoclast differentiation
- Principal Investigator
  
  OKAMATSU Yoshimasa
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
Determination of the specific phenotype markers of ex vivo expanded human peridontal ligament cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makoto
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
Mechanisms of bone resorption in alveolar bone of IL-1 transgenic mice
- Principal Investigator
  
  SHINKI Toshimasa
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nihon Pharmaceutical University
  Showa University
膜貫通型CD14発現のサイトカインによる制御および歯周病病型診断への応用の可能性
- Principal Investigator
  
  HASEGAWA Kohoji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
Study of Human Gingival Fibroblasts Heterogeneity. Comparison of the function in each stbsets cloned by cell surface molecule
- Principal Investigator
  
  MIYAZAWA Yasushi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Showa University
Corelation of IL-1B wnverting engyme with IL-1 production and Apoptosis in fibroblaPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makato
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  SHOWA UNIVERSITY
Development of a therapeutic method of bone repair using BMP responding mesencbymal cells
- Principal Investigator
  
  YAMAGUCHI Akira
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Participation of c-fosgene with pathogenesis of periodontitis
- Principal Investigator
  
  HASEGAWA Kohoji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University
Detection of the indicator of disease activity in gingival crevicular fluidPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makoto
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University
パノラマX線写真による若年者の歯槽骨吸収状態の経年的観察
- Principal Investigator
  
  鈴木康生
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  小児・社会系歯学
- Research Institution
  Showa University
The Possibility that Periodontal Ligament Cells can Differentiate into OsteoblastsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Makoto
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Showa University

All 2009 2008 2007

All Journal Article Presentation

[Journal Article] ヒト歯根膜細胞中に存在するアルカリフォスファターゼ陽性細胞と陰性細胞の特徴2009
- Author(s)
  鶴見亜有子, 小林誠, 村山怜一郎ら, (2番目)
- Journal Title
  
  Dental Med Res
  
  Volume: 29(1) Pages: 28-39
- NAID
  10025646140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592436
[Journal Article] 培養ヒト歯根膜細胞における各種腱・靱帯マーカー遺伝子の発現制御2008
- Author(s)
  三井将, 小林誠, 森高俊一郎ら, (2番目)
- Journal Title
  
  Dental Med Res
  
  Volume: 28(3) Pages: 137-149
- NAID
  10025645815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592436
[Journal Article] 培養ヒト歯根膜細胞におけるTwistと各種BMP antagonistの発現制御2008
- Author(s)
  森高俊一郎, 小林誠, 三井将ら, (2番目)
- Journal Title
  
  Dental Med Res
  
  Volume: 28(2) Pages: 67-76
- NAID
  10024381940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592436
[Journal Article] The changes of the tendon/ligament markers expression by induction of chondrogenic differentiation and TGF-β3 treatment in human periodontal ligament cells2008
- Author(s)
  Mitsui M, Kobayashi M, et al.
- Journal Title
  
  Dental Med Res 28(3)
  
  Pages: 137-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Journal Article] 培養ヒト歯根膜細胞における各種腱・靭帯マーカー遺伝子の発現制御.2008
- Author(s)
  三井将, 小林誠, ら
- Journal Title
  
  Dental Med Res 28
  
  Pages: 137-149
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] Characteristics of side population cells existing in periodontal ligament cells.2008
- Author(s)
  Koide Y, Kobayashi M, et al.
- Organizer
  86th General Session & Exhibition of the IADR and 32nd Annual Meeting of the CADR
- Place of Presentation
  Toronto, Canada
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] ヒト歯根膜細胞中のアルカリフォスファターゼ陰性細胞の特徴2008
- Author(s)
  鶴見亜有子, 小林誠, 奥津朋彦ら
- Organizer
  第129回日本歯科保存学会秋期学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-20592436
[Presentation] Characteristics of side population cells existing in human periodontal ligament cells2008
- Author(s)
  Koide Y, Kobayashi M, et al.
- Organizer
  86th General Session & Exhibition of the IADR and 32nd Annual Meeting of the CADR
- Place of Presentation
  Toronto, Canada
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] Characteristics of side cell population cells existing in periodontal ligament cells2008
- Author(s)
  Koide Y, Kobayashi M, et al.
- Organizer
  The 86th General Session % Exhibition of the IADR
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-20592436
[Presentation] Characteristics of side population cells existing in human periodontal ligament cells2008
- Author(s)
  Koide Y, Kobayashi M, et al.
- Organizer
  The 7^<TH> annual meeting of Japanese Society for regenerative medicine
- Place of Presentation
  Nagoya, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] 培養ヒト歯根膜細胞中に存在するSide Population細胞の特徴.2008
- Author(s)
  小出容子, 小林誠, ら
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] 培養ヒト歯根膜細胞中に存在するSide Population細胞の特徴2008
- Author(s)
  小出容子, 小林誠ら
- Organizer
  第7回日本再生医療学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20592436
[Presentation] Characteristics of side cell population cells existing in periodontal ligament cells2008
- Author(s)
  Koide Y, Kobayashi M, et al.
- Organizer
  The 86th General Session & Exhibition of the IADR
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-20592436
[Presentation] 培養ヒト歯根膜細胞における各種腱・靱帯マーカー遺伝子の発現制御.2007
- Author(s)
  三井将, 小林誠, ら
- Organizer
  第49回日本歯科基礎医学会
- Place of Presentation
  札幌
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592269
[Presentation] Regulation of expression of tendon/ligament marker molecules in human periodontal ligament cells2007
- Author(s)
  Mitsui M, Kobayashi M, et al.
- Organizer
  The 49^<TH> annual meeting of Japanese Association for Oral Biology
- Place of Presentation
  Sapporo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592269

1. MIYAGAWA Yasushi (90219775)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. OKAMATSU Yoshimasa (50286845)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. HASEGAWA Kohoji (70014024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKADA Takatora (20384323)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. OHAZAMA Atsushi (40266169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKIGUCHI Takashi (60317576)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 鈴木康生 (80107309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 角尾明美 (00227456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 向山賢一郎 (60190849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山下登 (00129876)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. USUI Michihiko (10453630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SHIONOME Manabu (50245809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NISHIHARA Tatsuji (80192251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YAMAGUCHI Akira (00142430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KATAOKA Hiroko (60286846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OHNO Kousuke (30112725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SAKAMOTO Keizou (50119195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 池田通 (00211029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SHINKI Toshimasa (90138420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIYAMOTO Youichi (20295132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SAKURADA Chikai (30279244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TAKAMI Masamichi (80307058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KAMIJYO Ryutaro (70233939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 守村直子 (00349044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. MURAKAMI Shinya (70239490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 野嶋直美 (50159951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBAYASHI Makoto 小林 誠

小林 誠 コバヤシ マコト

Research Projects

Research Products

Co-Researchers

Investigation for establishment of periodontal regenerative therapy using stem cells in cultured periodontal ligament cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of the unknown periodontal ligament-related moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of the role of chemokine in regulation of human osteoclast differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of the specific phenotype markers of ex vivo expanded human peridontal ligament cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of bone resorption in alveolar bone of IL-1 transgenic mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膜貫通型CD14発現のサイトカインによる制御および歯周病病型診断への応用の可能性

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of Human Gingival Fibroblasts Heterogeneity. Comparison of the function in each stbsets cloned by cell surface molecule

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Corelation of IL-1B wnverting engyme with IL-1 production and Apoptosis in fibroblaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a therapeutic method of bone repair using BMP responding mesencbymal cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Participation of c-fosgene with pathogenesis of periodontitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of the indicator of disease activity in gingival crevicular fluidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

パノラマX線写真による若年者の歯槽骨吸収状態の経年的観察

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Possibility that Periodontal Ligament Cells can Differentiate into OsteoblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

KOBAYASHI Makoto 小林誠

小林誠コバヤシマコト