Nara Hidetoshi 奈良英利

… Alternative Names

奈良英利ナラヒデトシ

NARA Hidetoshi 奈良英利

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Researcher Number	00375338
Other IDs
Affiliation (Current)	2025: 石巻専修大学, 理工学部, 教授
Affiliation (based on the past Project Information) *help	2023: 石巻専修大学, 理工学部, 教授 2018 – 2022: 石巻専修大学, 理工学部, 准教授 2014 – 2017: 山形大学, 医学部, 助教 2010 – 2012: 山形大学, 医学部, 助教 2005 – 2006: 山形大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Tumor biology Except Principal Investigator Immunology / Basic Section 56030:Urology-related / Basic Section 49070:Immunology-related / Urology
Keywords	Principal Investigator 免疫学 / 癌 / マイクロアレイ解析 / マウス / IL-21 / 免疫抑制 / インターロイキン（IL-）21 / 樹状細胞 / インターロイキン２１ Except Principal Investigator サイトカイン … More / 抗腫瘍活性 / 好中球 / 炎症 / 免疫チェックポイント阻害剤治療 / 免疫抑制活性 / 腎癌 / 膀胱癌 / MDSCｓ / MDSCs / BCG / IL-21 / 末梢血 / 腎がん / 免疫チェックポイント阻害剤 / 抗腫瘍免疫 / ADAM / ADAM17 / IL-12 / 腫瘍学 / 膀胱がん / 炎症性腸疾患 / 炎症性発癌 / AID / インターロイキン21 / 炎症性発がん / TH17 / 炎症性腸炎 / Ape1/Ref-1 / 自己免疫疾患 / エピジェネティクス Less

Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils
- Principal Investigator
  
  武田裕司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yamagata University
Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils
- Principal Investigator
  
  Takeda Yuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yamagata University
Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yamagata University
Enhancement of antitumor effect of IL-21 by improving cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Nara Hidetoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Ishinomaki Senshu University
  Yamagata University
Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer
- Principal Investigator
  
  Takeda Yuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yamagata University
IL-21-induced colitis-associated colorectal cancer
- Principal Investigator
  
  Asao Hironobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
TH17 cell induction through IL-21-Ape1/Ref-1 pathway
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Yamagata University

All 2024 2021 2019 2018 2017 2016 2013 2012 2011 2010 2005

All Journal Article Presentation

[Journal Article] GPI-80 Augments NF-κB Activation in Tumor Cells2021
- Author(s)
  Takeda Yuji、Kurota Yuta、Kato Tomoyuki、Ito Hiromi、Araki Akemi、Nara Hidetoshi、Saitoh Shinichi、Tanaka Nobuyuki、Tsuchiya Norihiko、Asao Hironobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 12027-12027
- DOI
  10.3390/ijms222112027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07380, KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-20K08580, KAKENHI-PROJECT-20K09554
[Journal Article] IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019
- Author(s)
  Araki Akemi、Jin Lianjin、Nara Hidetoshi、Takeda Yuji、Nemoto Nobuhito、Gazi Md Yeashin、Asao Hironobu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 11 Pages: 3326-3333
- DOI
  10.4049/jimmunol.1800550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma2019
- Author(s)
  Tomoyuki Kato, Yuji Takeda, Hiromi Ito, Yuta Kurota, Atsushi Yamagishi, Toshihiko Sakurai, Sei Naito, Akemi Araki, Hidetoshi Nara, Hironobu Asao, Norihiko Tsuchiya
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 249 Issue: 3 Pages: 203-212
- DOI
  10.1620/tjem.249.203
- NAID
  130007751389
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-17K11122
[Journal Article] Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-212018
- Author(s)
  Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
- Journal Title
  
  Cytokine
  
  Volume: 110 Pages: 194-203
- DOI
  10.1016/j.cyto.2018.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153, KAKENHI-PROJECT-17K11122
[Journal Article] nterleukin-21 attenuates FITC-induced contact hypersensitivity response via regulation of dendritic cell function2018
- Author(s)
  Nara H, Komatsu M, TekedaY, Araki A, Akhter N, Asao H
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 印刷中 Issue: 10 Pages: 2174-2184
- DOI
  10.1016/j.jid.2018.03.1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] Systemic neutrophil migration and rapid consumption of neutrophils in the spleen2018
- Author(s)
  Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
- Journal Title
  
  Data in Brief
  
  Volume: 20 Pages: 680-682
- DOI
  10.1016/j.dib.2018.08.090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals2017
- Author(s)
  Takeda Y, Nara H, Asao H.
- Journal Title
  
  Bulletin of the Yamagata University. Medical science : Yamagata medical journal
  
  Volume: 35 Pages: 21-32
- NAID
  120006334923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11122
[Journal Article] Role of Interleukin-21 isoform in dextran sulfate sodium (DSS)-inducedcolitis2013
- Author(s)
  Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, Jin L, Murata K, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume: 62 Issue: 2 Pages: 262-271
- DOI
  10.1016/j.cyto.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] IL-21 isoform is a membrane-bound ligand and activatesdirectly interacted cells2013
- Author(s)
  Nara H, Rahman M, Araki A, Jin L, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume: 61 Issue: 2 Pages: 656-663
- DOI
  10.1016/j.cyto.2012.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2012
- Author(s)
  Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T and Asao H
- Journal Title
  
  Biochem. Biophys. Res.Commun
  
  Volume: 420 Issue: 3 Pages: 628-634
- DOI
  10.1016/j.bbrc.2012.03.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PUBLICLY-23114707, KAKENHI-PROJECT-23590569
[Journal Article] WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor2011
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Cell Immunol
  
  Volume: 269 Issue: 1 Pages: 54-59
- DOI
  10.1016/j.cellimm.2011.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PROJECT-22591925
[Journal Article] WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor2011
- Author(s)
  Hidetoshi NARA, et al
- Journal Title
  
  Cellular Immunology
  
  Volume: 269 Pages: 54-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Regulation of interleukin-21 receptor expression and its signal transduction by WSB-22010
- Author(s)
  Hidetoshi NARA, et al
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 392 Pages: 171-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Regulation of interleukin-21 receptor expression and its signal transduction by WSB-22010
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 392 Issue: 2 Pages: 171-177
- DOI
  10.1016/j.bbrc.2010.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Novel polymorphism of the canine dopamine receptor D4 gene intron II region.2005
- Author(s)
  Nara H
- Journal Title
  
  Anim. Sci. J. 76
  
  Pages: 81-86
- NAID
  10017100281
- Data Source
  KAKENHI-PROJECT-17659139
[Presentation] Initial myeloid cell status is associated with clinical outcomes of renal cell carcinoma2024
- Author(s)
  Saima Sabrina, Yuji Takeda, Tomoyuki Kato, Shinichi Saitoh, Akemi Araki, Mikako Nagashima, Hidetoshi Nara, and Hironobu Asao
- Organizer
  The 52th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-23K08751
[Presentation] Interleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive state2017
- Author(s)
  Nara H, TAKEDA Y, Md. GAZI Y, NEMOTO N, ARAKI A, ASAO H.
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07153
[Presentation] 転移性腎細胞癌患者における末梢血中GPI-80発現は予後因子となりうる2017
- Author(s)
  加藤智幸，武田裕司，伊藤裕美，黒田悠太，奈良英利，櫻井俊彦，西田隼人，内藤整，川添久，荒木明美，一柳統，浅尾裕信，土谷順彦
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] 慢性炎症から発がんへのメカニズム解析　-大腸がん誘導マウスを用いて-2016
- Author(s)
  荒木明美, 金蓮今, 奈良英利, 武田裕司, 浅尾裕信
- Organizer
  日本細菌学会東北支部総会
- Place of Presentation
  北里大学獣医学部、十和田市
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-26460568
[Presentation] The unique action mechanism of IL-21 isoform2012
- Author(s)
  Hidetoshi Nara
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-22590432
[Presentation] The unique actionmechanism of IL-21 isoform2012
- Author(s)
  Hidetoshi Nara
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-22590432
[Presentation] IL-21 isoformactivates STAT3 without secretion2011
- Author(s)
  Hidetoshi Nara
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22590432
[Presentation] WSB family differentially regulate Interleukin-21 receptor expression and its signal transduction2010
- Author(s)
  Hidetoshi Nara
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe 24^<th> International Exhibition Hall, Japan
- Data Source
  KAKENHI-PROJECT-22590432

1. ASAO Hironobu (80250744)

# of Collaborated Projects: 8 results

# of Collaborated Products: 15 results
2. Takeda Yuji (90302299)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
3. ASAO Naoki (60241519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 加藤智幸 (40396560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 斉藤真一 (90536674)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 黒田悠太 (00594326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 土谷順彦 (70282176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 内藤整 (00431643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ARAKI AKEMI

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Nara Hidetoshi 奈良 英利

奈良 英利 ナラ ヒデトシ

NARA Hidetoshi 奈良 英利

Research Projects

Research Products

Co-Researchers

Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhancement of antitumor effect of IL-21 by improving cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-21-induced colitis-associated colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TH17 cell induction through IL-21-Ape1/Ref-1 pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GPI-80 Augments NF-κB Activation in Tumor Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-212018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] nterleukin-21 attenuates FITC-induced contact hypersensitivity response via regulation of dendritic cell function2018

Author(s)

Journal Title

Nara Hidetoshi 奈良英利

奈良英利ナラヒデトシ

NARA Hidetoshi 奈良英利

[Presentation] 慢性炎症から発がんへのメカニズム解析　-大腸がん誘導マウスを用いて-2016