Asao Hironobu 浅尾裕信

… Alternative Names

Researcher Number	80250744
Other IDs
Affiliation (Current)	2019 : 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2019 : 山形大学, 医学部, 教授 2010 – 2012 : 山形大学, 医学部, 教授 2003 – 2006 : Yamagata University, Fuculty of Medicine, Professor, 医学部, 教授 1999 – 2002 : Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2001 : 東北大学, 大学院・医学系研究所, 助教授 1994 – 1996 : 東北大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Immunology / 寄生虫学(含医用動物学) / Basic Section 49070:Immunology-related Except Principal Investigator Immunology / Immunology / Virology / Basic Section 49010:Pathological biochemistry-related / Tumor biology / Urology / Pediatrics
Keywords	Principal Investigator サイトカイン / サイトカイン情報伝達 / Hgs / Hrs / Grf40 / STAM / IL-21 / Smad / TNF-α / アポトーシス … More Except Principal Investigator OX40リガンド / IL-2 / 抗原提示細胞 / 制御性T細胞 / サイトカイン / IL-2受容体 / apoptosis / ヒト・パルボウイルス / 慢性関節リウマチ / 胎児水腫 / OX40 / CD4陽性T細胞 / 免疫寛容 / アポトーシス / シグナル伝達 / OX40L / XSCID / IL-2 receptor / T細胞 / γ鎖 / OX40L欠損マウス / OX40 ligand / リウマチ / IL-7 / 免疫制御 / 増殖シグナル / T細胞補助シグナル / Cytokine / 抗腫瘍活性 / FLIT / Transplantation immunity / G2 arrest / 免疫学 / rheumatoid arthritis / 癌 / 細胞周期制御 / Inflammatory bowel disease / Hrs / インターロイキン2(IL-2) / 抗原提示 / OX40L-deficient mice / Antigen presenting cell / 間質性肺炎 / 免疫抑制 / NS1非構造蛋白分子 / knockout mice / tyrosine kinase / 移植免疫 / Leishmania Major感染症 / 腫瘍学 / parvovirus / T cell costimulatory signal / hydrops fetalis / 伝染性紅斑 / OX40L-transgenic mice / 非免疫性胎児水腫 / Human parvovirus B19 / 自己免疫病 / Monoclonal antibody / 転写活性化因子 / IL-21 / TCR / γc鎖 / T-cell costimulatory signals / T cell differntiation and growth / 好中球 / interleukin 2 (IL-2) / インスリン抵抗性 / 実験的自己免疫性脳脊髄炎 / OX40L導入マウス / 5-アミノレブリン酸 / 小胞輸送 / 蛋白分解 / gene targetting mouse / regulatory T cells / 5'RACE / 自己免疫疾患 / 可溶化型 / JAK1,3 / 炎症反応 / FISH / T細胞補助刺激 / メタボリックシンドローム / Inflammation / 細胞内小胞輸送 / G-band / 全ゲノムシークエンス / チロシンキナーゼ / CD4^+ T cell / Interstitial pneumonia / マクロファージ / ALK関連腫瘍 / T細胞分化増殖 / ALK転座 / CD4 T cell / マウス / vesicle trafficking / Experimental autoimmune encephalomyelitis (EAE) / SARA / インターロイキン2 (IL-2) / CD4^+ T cells / Smad / Immune suppression / IBD / Hgs / 自己免疫 / 炎症 / サイイトカイン / STAM / 単クロン抗体 / non-immune hydrops fetalis / 樹状細胞 / 新生児間質性肺腫瘍 / γ鎖ノックアウトマウス / パルボウイルス / cytokine / Immunological tolerance / 膀胱がん / transgenic mice / NS1 / 膀胱癌 / 慢性炎症 / STAMs / TGF-β / ノックアウトマウス / 抗DNA抗体 Less

A novel model of the non-obese diabetes and investigation of immune abnormalityOngoing
- Principal Investigator
  
  斉藤真一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Yamagata University
膜結合型インターロイキン12（IL-12）による抗腫瘍免疫増強作用Principal InvestigatorOngoing
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yamagata University
IL-21のがん微小環境改善による抗腫瘍効果の増強Ongoing
- Principal Investigator
  
  奈良英利
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Yamagata University
腎癌と膀胱癌における免疫抑制型好中球と抗腫瘍型好中球の分類法確立Ongoing
- Principal Investigator
  
  武田裕司
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yamagata University
新生児肺腫瘍 (FLIT) における ALK と発症機序の解明Ongoing
- Principal Investigator
  
  小野田正志
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Yamagata University
IL-21-induced colitis-associated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Asao Hironobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
TH17 cell induction through IL-21-Ape1/Ref-1 pathwayPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
T細胞補助刺激分子を介した調節性T細胞機能制御
- Principal Investigator
  
  石井直人
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Immunological tolerance regulated by the interaction between T cell and antigen-presenting cell
- Principal Investigator
  
  ISHII Naoto
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Smads活性化因子Hgs/Hrsの細胞増殖・がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Functional analysis of neutrophils that infiltrated in the S.mansoni-induced hepatic granulomaPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu, 渡邊正
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Yamagata University
STAM1・STAM2二重欠損マウスにおけるT細胞分化異常の研究Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Smads活性化因子Hgs/Hrsの細胞増殖がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新規シグナル分子"AMSH"の遺伝子欠損による脳神経特異的なアポトーシス誘導Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Smads活性化に関わるチロシンリン酸化分子Hgsの細胞増殖がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Analysis of transgenic mice expressing human parvovirus non-stractual (NS1) protein
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
Regulation of autoimmune diseases by OX40-OX40L interact
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Grf40, A Novel Grb2 Family Member, Is Involved in T Cell SignalingPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Immune regulation by OX40/OX40 ligand system
- Principal Investigator
  
  ISHII Naoto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
インターロイキン2受容体γ鎖欠損マウスの解析Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Study of mechanism of X-licombined immunodeficiency caused by mutations of the IL-2 receptor gamma chain
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Development of immunosuppressant drugs based on inhibition of IL-2 function
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY

All 2018 2017 2016 2013 2012 2011 2010 2005 2003

All Journal Article Presentation Book

[Book] IL-21レセプターからのシグナル伝達分子2013
- Author(s)
  浅尾裕信
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] nterleukin-21 attenuates FITC-induced contact hypersensitivity response via regulation of dendritic cell function2018
- Author(s)
  Nara H, Komatsu M, TekedaY, Araki A, Akhter N, Asao H
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume : 印刷中
- DOI
  10.1016/j.jid.2018.03.1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals2017
- Author(s)
  Takeda Y, Nara H, Asao H.
- Journal Title
  
  Bulletin of the Yamagata University. Medical science : Yamagata medical journal
  
  Volume : 35 Pages : 21-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11122
[Journal Article] IL-21 isoform is a membrane-bound ligand and activatesdirectly interacted cells2013
- Author(s)
  Nara H, Rahman M, Araki A, Jin L, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume : 61 Pages : 656-663
- DOI
  10.1016/j.cyto.2012.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Role of Interleukin-21 isoform in dextran sulfate sodium (DSS)-inducedcolitis2013
- Author(s)
  Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, Jin L, Murata K, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume : 62 Pages : 262-271
- DOI
  10.1016/j.cyto.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] purinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2012
- Author(s)
  Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T and Asao H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume : 420 Pages : 628-634
- DOI
  10.1016/j.bbrc.2012.03.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PUBLICLY-23114707, KAKENHI-PROJECT-23590569
[Journal Article] WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor2011
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Cell Immunol
  
  Volume : 269 Pages : 54-59
- DOI
  10.1016/j.cellimm.2011.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PROJECT-22591925
[Journal Article] Regulation of interleukin-21 receptor expression and its signal transduction by WSB-22010
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume : 392 Pages : 171-177
- DOI
  10.1016/j.bbrc.2010.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2.2005
- Author(s)
  Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura K.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages : 10468-10477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Journal Article] Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.2003
- Author(s)
  Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309
  
  Pages : 848-856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Journal Article] Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.2003
- Author(s)
  Kikuchi, K., Ishii, N., Asao, H., Sugamura, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 306
  
  Pages : 637-643
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Presentation] 転移性腎細胞癌患者における末梢血中GPI-80発現は予後因子となりうる2017
- Author(s)
  加藤智幸，武田裕司，伊藤裕美，黒田悠太，奈良英利，櫻井俊彦，西田隼人，内藤整，川添久，荒木明美，一柳統，浅尾裕信，土谷順彦
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] GPI-80, a useful marker of MDSC in mRCC patients, is a reference for the search for new MDSC markers2017
- Author(s)
  Tomoyuki Kato, Yuji Takeda, Hitomi Ito, Yuta Kurota, Mayu Yagi, Toshihiko Sakurai, Sei Naito, Hisashi Kawazoe, Osamu Ichiyanagi, Norihiko Tsuchiya, Hironobu Asao
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] Interleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive state2017
- Author(s)
  Nara H, TAKEDA Y, Md. GAZI Y, NEMOTO N, ARAKI A, ASAO H.
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07153
[Presentation] 慢性炎症から発がんへのメカニズム解析　-大腸がん誘導マウスを用いて-2016
- Author(s)
  荒木明美, 金蓮今, 奈良英利, 武田裕司, 浅尾裕信
- Organizer
  日本細菌学会東北支部総会
- Place of Presentation
  北里大学獣医学部、十和田市
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-26460568
[Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction throughERK1/2pathway2011
- Author(s)
  Hironobu Asao
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22590432
[Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2011
- Author(s)
  Hironobu Asao, et al.
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22590432

1. ISHII Naoto (60291267)

# of Collaborated Projects : 9results

# of Collaborated Products : 3results
2. NARA Hidetoshi (00375338)

# of Collaborated Projects : 6results

# of Collaborated Products : 10results
3. SUGAMURA Kazuo (20117360)

# of Collaborated Projects : 6results

# of Collaborated Products : 0results
4. 武田裕司 (90302299)

# of Collaborated Projects : 5results

# of Collaborated Products : 5results
5. ASAO Naoki (60241519)

# of Collaborated Projects : 2results

# of Collaborated Products : 9results
6. TANAKA Nobuyuki (60280872)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. 竹下敏一 (60212023)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
8. SATOMI Susumu (00154120)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. SASAKI Takeshi (50110656)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. KASAI Noriyuki (60001947)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KONNO Tasuke (00004846)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. 仁木賢 (60241626)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 大保和之 (70250744)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 森田英嗣 (70344653)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 渡邊正 (60113990)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 荒木慶彦 (70250933)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 小野田正志 (10582562)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 黒田悠太 (00594326)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
19. 加藤智幸 (40396560)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
20. 土谷順彦 (70282176)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
21. 斉藤真一 (90536674)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. 中島修 (80312841)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. ARAKI AKEMI

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
24. 藤井穂高

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Asao Hironobu 浅尾 裕信

ASAO Hironobu 浅尾 裕信

Research Projects

Research Products

Co-Researchers

A novel model of the non-obese diabetes and investigation of immune abnormalityOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膜結合型インターロイキン12（IL-12）による抗腫瘍免疫増強作用Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IL-21のがん微小環境改善による抗腫瘍効果の増強Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎癌と膀胱癌における免疫抑制型好中球と抗腫瘍型好中球の分類法確立Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新生児肺腫瘍 (FLIT) における ALK と発症機序の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-21-induced colitis-associated colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

TH17 cell induction through IL-21-Ape1/Ref-1 pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析Principal Investigator

Principal Investigator

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Smads活性化因子Hgs/Hrsの細胞増殖・がん化における役割Principal Investigator

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Functional analysis of neutrophils that infiltrated in the S.mansoni-induced hepatic granulomaPrincipal Investigator

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Asao Hironobu 浅尾裕信

ASAO Hironobu 浅尾裕信