Asao Hironobu 浅尾裕信

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ASAO Hironobu 浅尾裕信

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Researcher Number	80250744
Other IDs
Affiliation (Current)	2025: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 山形大学, 医学部, 教授 2010 – 2012: 山形大学, 医学部, 教授 2003 – 2006: Yamagata University, Fuculty of Medicine, Professor, 医学部, 教授 1999 – 2002: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2001: 東北大学, 大学院・医学系研究所, 助教授 1994 – 1996: 東北大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Immunology / Immunology / Basic Section 50010:Tumor biology-related / Basic Section 49070:Immunology-related / 寄生虫学(含医用動物学) Except Principal Investigator Immunology / Basic Section 56030:Urology-related / Virology / Immunology … More / Basic Section 49010:Pathological biochemistry-related / Urology / Tumor biology / Pediatrics Less
Keywords	Principal Investigator サイトカイン / IL-21 / サイトカイン情報伝達 / TNF-α / Grf40 / Smad / Hrs / Hgs / アポトーシス / STAM … More / アロマターゼ / 乳癌 / 抗腫瘍免疫 / ADAM / ADAM17 / IL-12 / hepatic granuloma / neutrophil / S.Mansoni / サイトカイン産生 / 肝肉芽腫瘍手形成 / 好中球枯渇 / cマウス / BALB / 肝肉芽腫 / 好中球 / マンソン住血吸虫 / signal transduction / Grb2 family / TCR / Gads / Gbr2 / LAT / SLP76 / T細胞受容体情報伝達 / 炎症性腸疾患 / 炎症性発癌 / AID / インターロイキン21 / 炎症性発がん / TH17 / 炎症性腸炎 / Ape1/Ref-1 / 自己免疫疾患 / エピジェネティクス / EGF受容体 / SMAD / HGS / T細胞特異的遺伝子欠損マウス / 2 / STAM1 / アクチビン / AMSH / 細胞内シグナル伝達 / サイトカイン受容体共通γ鎖 / IL-2受容体 / チロシンキナーゼ … More Except Principal Investigator OX40リガンド / 好中球 / 抗腫瘍活性 / 炎症 / 抗原提示細胞 / IL-2 / サイトカイン / 制御性T細胞 / 免疫チェックポイント阻害剤治療 / 免疫抑制活性 / 腎癌 / 膀胱癌 / MDSCｓ / MDSCs / BCG / CD4陽性T細胞 / OX40L / OX40 / OX40L欠損マウス / apoptosis / 慢性関節リウマチ / ヒト・パルボウイルス / 胎児水腫 / アポトーシス / シグナル伝達 / XSCID / IL-2 receptor / γ鎖 / IL-2受容体 / 免疫抑制 / 免疫寛容 / T細胞 / 末梢血 / 腎がん / 免疫チェックポイント阻害剤 / 脂肪組織 / LPS / マクロファージ / 加齢 / 活性酸素種 / リポポリサッカライド / 炎症性サイトカイン / 自然免疫 / 5-アミノレブリン酸 / メタボリックシンドローム / 慢性炎症 / インスリン抵抗性 / 糖尿病 / 腫瘍学 / 膀胱がん / 免疫学 / 癌 / マイクロアレイ解析 / マウス / IL-21 / インターロイキン（IL-）21 / 樹状細胞 / インターロイキン２１ / G-band / 全ゲノムシークエンス / 5'RACE / FISH / A2M-ALK / ALK関連腫瘍 / FLIT / 新生児間質性肺腫瘍 / ALK転座 / T-cell costimulatory signals / regulatory T cells / Antigen presenting cell / CD4^+ T cell / Immunological tolerance / 自己免疫疾患 / T細胞補助刺激 / Inflammation / CD4 T cell / T cell costimulatory signal / vesicle trafficking / Cytokine / TCR / IL-7 / STAM / 自己免疫 / 蛋白分解 / 小胞輸送 / Hrs / STAMs / γc鎖 / 抗原提示 / 炎症反応 / T細胞補助シグナル / 細胞内小胞輸送 / Inflammatory bowel disease / Interstitial pneumonia / CD4^+ T cells / OX40L-transgenic mice / 自己免疫病 / 抗DNA抗体 / IBD / 間質性肺炎 / OX40L導入マウス / G2 arrest / non-immune hydrops fetalis / NS1 / transgenic mice / Human parvovirus B19 / 細胞周期制御 / NS1非構造蛋白分子 / Experimental autoimmune encephalomyelitis (EAE) / OX40L-deficient mice / OX40 ligand / Leishmania Major感染症 / 実験的自己免疫性脳脊髄炎 / hydrops fetalis / rheumatoid arthritis / parvovirus / 非免疫性胎児水腫 / 伝染性紅斑 / 転写活性化因子 / リウマチ / パルボウイルス / knockout mice / tyrosine kinase / T cell differntiation and growth / cytokine / interleukin 2 (IL-2) / JAK1,3 / γ鎖ノックアウトマウス / サイイトカイン / インターロイキン2 (IL-2) / ノックアウトマウス / チロシンキナーゼ / T細胞分化増殖 / インターロイキン2(IL-2) / Transplantation immunity / Monoclonal antibody / Immune suppression / 増殖シグナル / 可溶化型 / 免疫制御 / 移植免疫 / 単クロン抗体 / gene targetting mouse / SARA / Hgs / Smad / TGF-β Less

インターロイキン21によるエストロゲン産生と乳がん発生機構の解明Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yamagata University
Clinical application of cancer immunity-induced neutrophils and immunosuppressive neutrophils
- Principal Investigator
  
  武田裕司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yamagata University
Search for TPO for immunotherapy using immunosuppressive neutrophils and cancer immune-promoting neutrophils
- Principal Investigator
  
  Takeda Yuji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Yamagata University
A novel model of the non-obese diabetes and investigation of immune abnormality
- Principal Investigator
  
  Saitoh Shinichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Yamagata University
Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)Principal Investigator
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Yamagata University
Enhancement of antitumor effect of IL-21 by improving cancer microenvironment
- Principal Investigator
  
  Nara Hidetoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Ishinomaki Senshu University
  Yamagata University
Establishment of separation method for immunosuppressive neutrophils and antitumor neutrophils in renal cancer and bladder cancer
- Principal Investigator
  
  Takeda Yuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Yamagata University
Identification of novel ALK rearrangements in neonates with fetal lung interstitial tumor
- Principal Investigator
  
  Onoda Tadashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Yamagata University
IL-21-induced colitis-associated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Asao Hironobu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
TH17 cell induction through IL-21-Ape1/Ref-1 pathwayPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Yamagata University
T細胞補助刺激分子を介した調節性T細胞機能制御
- Principal Investigator
  
  石井直人
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Immunological tolerance regulated by the interaction between T cell and antigen-presenting cell
- Principal Investigator
  
  ISHII Naoto
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Smads活性化因子Hgs/Hrsの細胞増殖・がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Signal transducing pathways in immune cells and immunological disorders caused by their dysfunctions
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Functional analysis of neutrophils that infiltrated in the S.mansoni-induced hepatic granulomaPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu, 渡邊正
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  寄生虫学(含医用動物学)
- Research Institution
  Yamagata University
STAM1・STAM2二重欠損マウスにおけるT細胞分化異常の研究Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Smads活性化因子Hgs/Hrsの細胞増殖がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
新規シグナル分子"AMSH"の遺伝子欠損による脳神経特異的なアポトーシス誘導Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Smads活性化に関わるチロシンリン酸化分子Hgsの細胞増殖がん化における役割Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Analysis of transgenic mice expressing human parvovirus non-stractual (NS1) protein
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
Regulation of autoimmune diseases by OX40-OX40L interact
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Smads活性化に関わるチロシンリン酸化分子Hrsの細胞増殖がん化における役割
- Principal Investigator
  
  竹下敏一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Grf40, A Novel Grb2 Family Member, Is Involved in T Cell SignalingPrincipal Investigator
- Principal Investigator
  
  ASAO Hironobu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Immune regulation by OX40/OX40 ligand system
- Principal Investigator
  
  ISHII Naoto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Establishment of Model Mice of Rheumatoid Arthritis by using nonstructural protein 1 (NS1) of parvovirus B19
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tohoku University
インターロイキン2受容体γ鎖欠損マウスの解析Principal Investigator
- Principal Investigator
  
  浅尾裕信
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Study of mechanism of X-licombined immunodeficiency caused by mutations of the IL-2 receptor gamma chain
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tohoku University
Development of immunosuppressant drugs based on inhibition of IL-2 function
- Principal Investigator
  
  SUGAMURA Kazuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  TOHOKU UNIVERSITY

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All Journal Article Presentation Book

[Book] Mehods in Molecular Biology 1916, Pre-Clinical Models2019
- Author(s)
  Takeda Y, Asao H, Wakabayashi I.
- Total Pages
  343
- Publisher
  Springer
- ISBN
  9781493989935
- Data Source
  KAKENHI-PROJECT-17K11122
[Book] IL-21レセプターからのシグナル伝達分子2013
- Author(s)
  浅尾裕信
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma2023
- Author(s)
  Saima Sabrina, Yuji Takeda, Tomoyuki Kato, Sei Naito, Hiromi Ito, Yuki Takai, Masaki Ushijima, Takafumi Narisawa, Hidenori Kanno, Toshihiko Sakurai, Shinichi Saitoh, Akemi Araki, Norihiko Tsuchiya and Hironobu Asao
- Journal Title
  
  Biomedicines
  
  Volume: 11 Issue: 5 Pages: 1296-1296
- DOI
  10.3390/biomedicines11051296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09554, KAKENHI-PROJECT-22K09440, KAKENHI-PROJECT-23K08751
[Journal Article] Five Patterns of Cell Signaling Associated with Cell Behavior2022
- Author(s)
  akeda Yuji, Kawano Kazuharu, Ma Rui, Saitoh Shinichi, Asao Hironobu
- Journal Title
  
  山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal
  
  Volume: 40 Issue: 1 Pages: 1-20
- DOI
  10.15022/00005304
- NAID
  120007193319
- URL
  https://yamagata.repo.nii.ac.jp/records/5379
- Year and Date
  2022-02-22
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09554
[Journal Article] GPI-80 Augments NF-κB Activation in Tumor Cells2021
- Author(s)
  Takeda Yuji、Kurota Yuta、Kato Tomoyuki、Ito Hiromi、Araki Akemi、Nara Hidetoshi、Saitoh Shinichi、Tanaka Nobuyuki、Tsuchiya Norihiko、Asao Hironobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 21 Pages: 12027-12027
- DOI
  10.3390/ijms222112027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07380, KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-20K08580, KAKENHI-PROJECT-20K09554
[Journal Article] IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019
- Author(s)
  Araki Akemi、Jin Lianjin、Nara Hidetoshi、Takeda Yuji、Nemoto Nobuhito、Gazi Md Yeashin、Asao Hironobu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 11 Pages: 3326-3333
- DOI
  10.4049/jimmunol.1800550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma2019
- Author(s)
  Tomoyuki Kato, Yuji Takeda, Hiromi Ito, Yuta Kurota, Atsushi Yamagishi, Toshihiko Sakurai, Sei Naito, Akemi Araki, Hidetoshi Nara, Hironobu Asao, Norihiko Tsuchiya
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 249 Issue: 3 Pages: 203-212
- DOI
  10.1620/tjem.249.203
- NAID
  130007751389
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09704, KAKENHI-PROJECT-17K11122
[Journal Article] Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL-212018
- Author(s)
  Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
- Journal Title
  
  Cytokine
  
  Volume: 110 Pages: 194-203
- DOI
  10.1016/j.cyto.2018.05.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153, KAKENHI-PROJECT-17K11122
[Journal Article] nterleukin-21 attenuates FITC-induced contact hypersensitivity response via regulation of dendritic cell function2018
- Author(s)
  Nara H, Komatsu M, TekedaY, Araki A, Akhter N, Asao H
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 印刷中 Issue: 10 Pages: 2174-2184
- DOI
  10.1016/j.jid.2018.03.1508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] Systemic neutrophil migration and rapid consumption of neutrophils in the spleen2018
- Author(s)
  Takeda Yuji、Kato Tomoyuki、Nemoto Nobuhito、Araki Akemi、Gazi Mohammad Yeashin、Nara Hidetoshi、Asao Hironobu
- Journal Title
  
  Data in Brief
  
  Volume: 20 Pages: 680-682
- DOI
  10.1016/j.dib.2018.08.090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07153
[Journal Article] Analysis of signal transducers using flow cytometry is useful for detection of contractive and fluctuating signals2017
- Author(s)
  Takeda Y, Nara H, Asao H.
- Journal Title
  
  Bulletin of the Yamagata University. Medical science : Yamagata medical journal
  
  Volume: 35 Pages: 21-32
- NAID
  120006334923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11122
[Journal Article] Role of Interleukin-21 isoform in dextran sulfate sodium (DSS)-inducedcolitis2013
- Author(s)
  Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana FM, Jin L, Murata K, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume: 62 Issue: 2 Pages: 262-271
- DOI
  10.1016/j.cyto.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] IL-21 isoform is a membrane-bound ligand and activatesdirectly interacted cells2013
- Author(s)
  Nara H, Rahman M, Araki A, Jin L, Takeda Y and Asao H
- Journal Title
  
  Cytokine
  
  Volume: 61 Issue: 2 Pages: 656-663
- DOI
  10.1016/j.cyto.2012.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2012
- Author(s)
  Juliana FM, Nara H, Onoda T, Rahman M, Araki A, Jin L, Fujii H, Tanaka N, Hoshino T and Asao H
- Journal Title
  
  Biochem. Biophys. Res.Commun
  
  Volume: 420 Issue: 3 Pages: 628-634
- DOI
  10.1016/j.bbrc.2012.03.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PUBLICLY-23114707, KAKENHI-PROJECT-23590569
[Journal Article] WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor2011
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Cell Immunol
  
  Volume: 269 Issue: 1 Pages: 54-59
- DOI
  10.1016/j.cellimm.2011.03.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432, KAKENHI-PROJECT-22591925
[Journal Article] Regulation of interleukin-21 receptor expression and its signal transduction by WSB-22010
- Author(s)
  Nara H, Onoda T, Rahman M, Araki A, Juliana FM, Tanaka N and Asao H
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 392 Issue: 2 Pages: 171-177
- DOI
  10.1016/j.bbrc.2010.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590432
[Journal Article] Hrs, a mammalian master molecule in vesicular transport and protein-sorting, suppresses the degradation of ESCRT proteins STAM1 and STAM2.2005
- Author(s)
  Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura K.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 10468-10477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Journal Article] Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.2003
- Author(s)
  Kikuchi, K., Ishii, N., Asao, H., Sugamura, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 306
  
  Pages: 637-643
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Journal Article] Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.2003
- Author(s)
  Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., Sugamura, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 309
  
  Pages: 848-856
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390155
[Presentation] IL-21 isoform transgenic mice spontaneously develop mammary tumors2024
- Author(s)
  Akemi Araki, Shinichi Saitoh, Yuji Takeda, Saima Sabrina, Risako Yamaguchi, Mikako Nagashima, Yusuke Nouchi, Hironobu Asao
- Organizer
  Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-23K06606
[Presentation] Initial myeloid cell status is associated with clinical outcomes of renal cell carcinoma2024
- Author(s)
  Saima Sabrina, Yuji Takeda, Tomoyuki Kato, Shinichi Saitoh, Akemi Araki, Mikako Nagashima, Hidetoshi Nara, and Hironobu Asao
- Organizer
  The 52th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-23K08751
[Presentation] IL-21 isoform transgenic mice spontaneously develop breast cancer2024
- Author(s)
  Akemi Araki, Shinichi Saitoh, Yuji Takeda, Naing Ye Aung, Masahiro Yamamoto, Saima Sabrina, Risako Yamaguchi, Mikako Nagashima, Yusuke Nouchi, Mitsuru Futakuchi, Hironobu Asao
- Organizer
  The 52th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-23K08751
[Presentation] 好中球の活性化パターンは、シグナル伝達分子の変動係数と関連する：シミュレーションによる細胞挙動の検証2023
- Author(s)
  武田裕司、大和田真帆、Sabrina Saima、野内雄介、永嶋美華子、荒木明美、斉藤真一、浅尾裕信
- Organizer
  第34回日本生体防御学会
- Data Source
  KAKENHI-PROJECT-23K08751
[Presentation] 5-アミノレブリン酸生合成不全マウスは炎症反応性が低下する2022
- Author(s)
  斉藤真一、武田裕司、Koen van Wijk、岡野聡、中島修、浅尾裕信
- Organizer
  第10回ポルフィリン-ALA学会年会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] MDSCs function analysis as a prediction of therapeutic effect for patients with advanced renal cell carcinoma2022
- Author(s)
  Saima S, Kato T, Takeda Y, Naito S, Ito H, Takai Y, Ushijima M, Ozawa M, Narisawa T, Kanno H, Sakurai T, Tsuchiya N, and Asao H
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K09554
[Presentation] The role of GPI-80 as a predicting marker of the therapeutic efficacy during immune checkpoint inhibition therapy in advanced renal cell carcinoma　patients2022
- Author(s)
  Sabrina S, Takeda Y, Kato T, Naito S, Ito H, Takai Y, Narisawa T, Kanno H, Sakurai T, Shinichi S, Akemi A, Tsuchiya N, and Asao H
- Organizer
  第74回　日本細菌学会東北支部会　学術集会
- Data Source
  KAKENHI-PROJECT-20K09554
[Presentation] Anti-tumor response during intravesical immunotherapy with BCG for non-muscle invasive bladder cancer2021
- Author(s)
  Takeda Y, Kato T, Shinichi S, Akemi A, Asao H
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K09554
[Presentation] 5-aminolevulinic acid (5-ALA) synthesis deficient mice display an immune abnormality and reduced cytokine release2021
- Author(s)
  Saitoh S, Takeda Y, van Wijk K, Nakajima O, Asao H.
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] Heterogeneity of neutrophils in renal cell and urothelial carcinoma patients during immune checkpoint inhibition therapy2021
- Author(s)
  Saima S, Kato T, Takeda Y, Naito S, Ito H, Takai Y, Ushijima M, Ozawa M, Narisawa T, Kanno H,Sakurai T, Tsuchiya N, Asao H
- Organizer
  第80回日本癌学会
- Data Source
  KAKENHI-PROJECT-20K09554
[Presentation] 5-アミノレブリン酸(5-ALA)生合成不全マウスにおける非肥満型インスリン抵抗性の発症と免疫応答・サイトカイン産生能の低下2021
- Author(s)
  斉藤真一、武田裕司、Koen van Wijk、中島修、浅尾裕信
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] 膀胱癌BCG膀胱内注入治療時に出現する抗腫瘍型好中球の同定2021
- Author(s)
  武田裕司, 加藤智幸, Sabrina Saima, 内藤整, 伊藤裕美, 牛島正毅, 成澤貴史, 黒田悠太, 菅野秀典, 斉藤真一, 土谷順彦, 浅尾裕信
- Organizer
  山形大学医学部実験動物セミナー・第32回研究成果発表会
- Data Source
  KAKENHI-PROJECT-20K09554
[Presentation] Function of GPI-80 on prostate cancer cell line, PC3 cells2019
- Author(s)
  Takeda Yuji, Kurota Yuta, Kato Tomoyuki, Araki Akemi, Saitoh Shinichi, and Asao Hironobu:
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] Immune abnormality in 5-aminolevulinic acid (ALA) synthesis deficient mice, which is a novel model of the non-obese diabetes2019
- Author(s)
  Saitoh Shinichi, Takeda Yuji, Wijk Koen van, Kimura Tomohiro, Okano Satoshi, Nakajima Osamu, and Hironobu Asao
- Organizer
  The 7th International ALA and Porphyrin Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] Myeloid cell heterogeneity indicating appearance of myeloid derived suppressor cells (MDSCs)in peripheral blood of metastatic renal cell carcinoma (mRCC)2019
- Author(s)
  Tomoyuki Kato, Yuji Takeda, Yuta Kurota, Sei Naito, Hiromi Ito, Akemi Araki, Hironobu Asao, Norihiko Tsuchiya
- Organizer
  ASCO GU－Genitourinary Cancers Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] 5-ALA生合成不全マウスにおける非肥満型糖尿病モデルの検討と免疫異常の解析2019
- Author(s)
  斉藤真一、荒木明美、武田裕司、Koen van Wijk、木村朋寛、岡野聡、中島修、浅尾裕信
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] IL-21isoform過剰発現マウスにおける高脂肪食性肥満の抑制と脂肪組織異常2019
- Author(s)
  斉藤真一、荒木明美、武田裕司、浅尾裕信
- Organizer
  第73回日本細菌学会東北支部総会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] ALA生合成不全マウ糖代謝異常の分子機構解析2019
- Author(s)
  斉藤真一、武田裕司、Koen van Wijk、木村朋寛、岡野聡、尾崎司、浅尾裕信、中島修
- Organizer
  第９回ポルフィリン-ALA学会年会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] Increased Development of Colitis-Associated Colon Cancer in IL-21-isoform transgenic mice: Possible Involvement of Activation-Induced Cytidine Deaminase Expression2019
- Author(s)
  Araki Akemi, Jin Lianjin, Nara Hidetoshi, Takeda Yuji, Saitoh Shinichi, Nemoto Nobuhito, Md Yeashin Gazi, and Asao Hironobu
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07380
[Presentation] Analysis of urinary leukocytes during intravesical immunotherapy with BCG for non-muscle invasive bladder cancer2018
- Author(s)
  Takeda Yuji, Kato Tomoyuki, Kurota Yuta, Ito Hiromi, Akemi Araki, Tsuchiya Norihiko, and Asao Hironobu
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] Interleukin21 arrests bone marrow derived dendritic cells PD-L1 high immunosuppressive state2017
- Author(s)
  Nara H, TAKEDA Y, Md. GAZI Y, NEMOTO N, ARAKI A, ASAO H.
- Organizer
  第46回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07153
[Presentation] GPI-80, a useful marker of MDSC in mRCC patients, is a reference for the search for new MDSC markers2017
- Author(s)
  Tomoyuki Kato, Yuji Takeda, Hitomi Ito, Yuta Kurota, Mayu Yagi, Toshihiko Sakurai, Sei Naito, Hisashi Kawazoe, Osamu Ichiyanagi, Norihiko Tsuchiya, Hironobu Asao
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] 転移性腎細胞癌患者における末梢血中GPI-80発現は予後因子となりうる2017
- Author(s)
  加藤智幸，武田裕司，伊藤裕美，黒田悠太，奈良英利，櫻井俊彦，西田隼人，内藤整，川添久，荒木明美，一柳統，浅尾裕信，土谷順彦
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11122
[Presentation] 慢性炎症から発がんへのメカニズム解析　-大腸がん誘導マウスを用いて-2016
- Author(s)
  荒木明美, 金蓮今, 奈良英利, 武田裕司, 浅尾裕信
- Organizer
  日本細菌学会東北支部総会
- Place of Presentation
  北里大学獣医学部、十和田市
- Year and Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-26460568
[Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction throughERK1/2pathway2011
- Author(s)
  Hironobu Asao
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22590432
[Presentation] Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ape1/Ref-1) is essential for IL-21-induced signal transduction through ERK1/2 pathway2011
- Author(s)
  Hironobu Asao, et al.
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-22590432

1. ISHII Naoto (60291267)

# of Collaborated Projects: 9 results

# of Collaborated Products: 3 results
2. NARA Hidetoshi (00375338)

# of Collaborated Projects: 8 results

# of Collaborated Products: 14 results
3. Takeda Yuji (90302299)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
4. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. Saitoh Shinichi (90536674)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
6. ASAO Naoki (60241519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
7. TANAKA Nobuyuki (60280872)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 竹下敏一 (60212023)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 加藤智幸 (40396560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
10. SATOMI Susumu (00154120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SASAKI Takeshi (50110656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KASAI Noriyuki (60001947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KONNO Tasuke (00004846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Onoda Tadashi (10582562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 仁木賢 (60241626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大保和之 (70250751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 森田英嗣 (70344653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 渡邊正 (60113990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 荒木慶彦 (70250933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 黒田悠太 (00594326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 土谷順彦 (70282176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. 中島修 (80312841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
23. 内藤整 (00431643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. ARAKI AKEMI

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Asao Hironobu 浅尾 裕信

ASAO Hironobu 浅尾 裕信

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インターロイキン21によるエストロゲン産生と乳がん発生機構の解明Principal Investigator

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Enhancement of anti-tumor immunity with membrane-bound interleukin 12 (IL-12)Principal Investigator

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IL-21-induced colitis-associated colorectal cancerPrincipal Investigator

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TH17 cell induction through IL-21-Ape1/Ref-1 pathwayPrincipal Investigator

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インターロイキン21とその受容体発現に対するエピジェネティックな制御系の解析Principal Investigator

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Smads活性化因子Hgs/Hrsの細胞増殖・がん化における役割Principal Investigator

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Asao Hironobu 浅尾裕信

ASAO Hironobu 浅尾裕信