Uemura Kengo 植村健吾

… Alternative Names

UEMURA Kengo 植村健吾

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Researcher Number	00378663
Affiliation (Current)	2025: 京都大学, 医学研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2016: 京都大学, 医学研究科, 非常勤講師 2016: 京都大学, 医学研究科, 非常勤講師、客員研究員 2013 – 2015: 京都大学, 医学(系)研究科(研究院), その他 2011 – 2012: 京都大学, 医学(系)研究科(研究院), 助教 2007 – 2008: Kyoto University, Graduate School of Medicine, Assistant Professor 2006: 京都大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Nerve anatomy/Neuropathology / Biological Sciences
Keywords	Principal Investigator 認知症 / アルツハイマー病 / 脳、神経 / 神経分子病態学 / アミロイド前駆体蛋白 / 国際情報交流（アメリカ） / 神経変性疾患 / 脳・神経 / 痴呆 / 神経科学 … More Except Principal Investigator … More N-cadherin / シナプス / プレセニリン / アルツハイマー病 / シグナル伝達 / リン酸化 / カテニン / カドヘリン / シナプス可塑性 / catenin / cadherin / signal transduction / phosphorylation / synapse / presenilin / Alzheimer's disease / インスリン / 認知症 / 神経変性 / 老化 / GSK3β Less

The examination of AD pathology from the perspective of the astrocyte-neuron interaction: the participation of IGFBP-3 released by astrocytes.Principal Investigator
- Principal Investigator
  
  Uemura Kengo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
abcPrincipal Investigator
- Principal Investigator
  
  UEMURA Kengo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Analysis of the mechanism of pathological synaptic alterations in Alzheimer's disease
- Principal Investigator
  
  KINOSHITA Ayae
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto University
プレセニリン機能障害によるシナプス制御機構の破綻
- Principal Investigator
  
  KINOSHITA Ayae
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
プレセニリンを介したカドヘリンーカテニン複合体とシグナル伝達のクロストーク
- Principal Investigator
  
  木下彩栄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
アルツハイマー病原因遺伝子プレセリニン機能障害によるシナプス変性機構の解明Principal Investigator
- Principal Investigator
  
  植村健吾
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University
Investigation of the synaptic dissociation mechanism
- Principal Investigator
  
  KINOSHITA Ayae
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Kyoto University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.2015
- Author(s)
  Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R, Kinoshita A.
- Journal Title
  
  Mol Brain
  
  Volume: 4;8(1) Issue: 1 Pages: 82-82
- DOI
  10.1186/s13041-015-0174-2
- NAID
  120005708017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461270, KAKENHI-PLANNED-23111002
[Journal Article] High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.2015
- Author(s)
  Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M, Kubota M, Okawa K, Ihara M, Shimohama S, Uemura K, Kinoshita A.
- Journal Title
  
  PLoS One.
  
  Volume: 10(9) Issue: 9 Pages: e0131199-e0131199
- DOI
  10.1371/journal.pone.0131199
- NAID
  120005947169
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461270
[Journal Article] Idiopathic Normal Pressure Hydrocephalus has a Different Cerebrospinal Fluid Biomarker Profile from Alzheimer's Disease2014
- Author(s)
  Naoto Jingami, Megumi Asada-Utsugi, Kengo Uemura, Rio Noto, Makio Takahashi, Akihiko Ozaki, Takeshi Kihara, Takashi Kageyama, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita.
- Journal Title
  
  Jounral of Alzheimer's Disease
  
  Volume: 126（４） Issue: 1 Pages: 675-81
- DOI
  10.3233/jad-142622
- NAID
  120005593597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26461270, KAKENHI-PLANNED-23111002
[Journal Article] Copper enhances APP dimerization and promotes Aβproduction2013
- Author(s)
  Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K
- Journal Title
  
  Neurosci Lett
  
  Volume: 547 Pages: 10-5
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] Copper enhances APP dimerization and promotes Aβ production.2013
- Author(s)
  Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S, Takahashi R, Kinoshita A, Uemura K.
- Journal Title
  
  Neurosci Lett
  
  Volume: 547 Pages: 10-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.2012
- Author(s)
  Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A.
- Journal Title
  
  Neurobiol Aging
  
  Volume: 33
- NAID
  120003988394
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice2012
- Author(s)
  Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, ShimohamaS, Kihara T, Kinoshita A
- Journal Title
  
  Neurobiology of Aging
  
  Volume: 33 Issue: 5 Pages: 11-23
- DOI
  10.1016/j.neurobiolaging.2011.10.028
- NAID
  120003988394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500336, KAKENHI-PROJECT-23390233, KAKENHI-PROJECT-23591243, KAKENHI-PROJECT-23650182, KAKENHI-PUBLICLY-24111524
[Journal Article] Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling2012
- Author(s)
  Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A.
- Journal Title
  
  J Neurochem
  
  Volume: 121 Issue: 6 Pages: 964-973
- DOI
  10.1111/j.1471-4159.2012.07741.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659529, KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23591243, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-24111524
[Journal Article] Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling2012
- Author(s)
  Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A
- Journal Title
  
  J Neurochem
  
  Volume: 121(6) Pages: 964-73
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice.2012
- Author(s)
  Maesako M
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 27 Pages: 23024-23033
- DOI
  10.1074/jbc.m112.367011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390232, KAKENHI-PROJECT-23591243, KAKENHI-ORGANIZER-23111001, KAKENHI-PLANNED-23111002, KAKENHI-PUBLICLY-24111524
[Journal Article] N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβproduction2011
- Author(s)
  Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A
- Journal Title
  
  J Neurochem
  
  Volume: 119(2) Pages: 354-63
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein : implications for neurodegeneration in Alzheimer disease2011
- Author(s)
  Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 7619-7628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage.2011
- Author(s)
  Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A
- Journal Title
  
  Neuroscience 177
  
  Pages: 298-307
- NAID
  120002970866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.2011
- Author(s)
  Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A.
- Journal Title
  
  J Neurochem.
  
  Volume: 119 Pages: 354-63
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] Insight into "synaptopathy" in Alzheimer's disease2011
- Author(s)
  Kuzuya A, Uemura K, Kinoshita A
- Journal Title
  
  Journal of Alzheimer's Disease Research
  
  Volume: In press
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Effect of glycogen synthase kinase 3 β-mediated presenilin 1 phosphorylation on amyloid β production is negatively regulated by insulin receptor cleavage2011
- Author(s)
  Maesako M, Uemura K, Kubota M, Hiyoshi K, Ando K, Kuzuya A, Kihara T, Asada M, Akiyama H, Kinoshita A
- Journal Title
  
  Neuroscience
  
  Volume: 177 Pages: 298-307
- NAID
  120002970866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein : implications for neurodegeneration in Alzheimer disease.2011
- Author(s)
  Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
- Journal Title
  
  J Biol Chem 286
  
  Pages: 7619-7628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism.2011
- Author(s)
  Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Kihara T, Kinoshita A.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Pages: 25309-16
- Data Source
  KAKENHI-PROJECT-23591243
[Journal Article] The cleavage of N-cadherin is essential for chondrocyte differenciaten.2010
- Author(s)
  Nakazora N, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A.
- Journal Title
  
  Biochem Biophys Res Commun 400
  
  Pages: 493-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity.2010
- Author(s)
  Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A, Takahashi R.
- Journal Title
  
  Biochem Biophys Res Commun 391
  
  Pages: 1240-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Insulin regulates Presenilin 1 localization via PI3K/Akt signaling.2010
- Author(s)
  Maesako M, Uemura K, Kubota M, Ando K, Kuzuya A, Kihara T, Kinoshita A
- Journal Title
  
  Nerosci Lett 483
  
  Pages: 157-161
- NAID
  120002484938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] The cleavage of N-cadherin is essential for chondrocyte differentiation2010
- Author(s)
  Nakazora S, Matsumine A, Iino T, Hasegawa M, Kinoshita A, Uemura K, Niimi R, Uchida A, Sudo A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 400 Pages: 493-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Insulin regulates Presenilin 1 localization via PI3K/Akt signaling2010
- Author(s)
  Maesako M, Uemura K, Kubota M, Ando K, Kuzuya A, Asada M, Kihara T, Kinoshita A
- Journal Title
  
  Neuroscience Letters
  
  Volume: 483 Pages: 157-161
- NAID
  120002484938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Cronic cerebral hypoperfusion accelerates amyloid β deposition in APPSweInd transgenic mouse.2009
- Author(s)
  Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, Kihara T, Asada-Utsugi M, Kinoshita A, Takahashi R.
- Journal Title
  
  Brain Research 1294
  
  Pages: 202-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] N-cadherin-based adhesion enhances Abeta release and decreased Abeta42/40 ratio2009
- Author(s)
  Uemura K, Lill CM, Banks M, Aoyagi N, Ando K, 久保田正和, 木原武士, Nishimoto T, Sugimoto H, 高橋良輔, Hyman BT, Shimohama S, 木下彩栄
- Journal Title
  
  Journal of Neurochemistry 156
  
  Pages: 350-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] N-cadherin-based adhesion enhances Aβ release and decrerased Aβ42/40 ratio.2009
- Author(s)
  Uemura, K, Lill CM, Banks M, Aoyagi N, Ando, K., Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A
- Journal Title
  
  J Neurochem 156
  
  Pages: 350-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.2009
- Author(s)
  Uemura K, et al.
- Journal Title
  
  Journal of Neurochemistry 108
  
  Pages: 350-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwedish transgenic mouse2009
- Author(s)
  Kitaguchi H, Tomimoto H, Ihara M, Shibata M, Uemura K, Kalaria RN, 木原武士, Asada-Utsugi M, 木下彩栄, 高橋良輔
- Journal Title
  
  Brain Research 1294
  
  Pages: 202-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] γセクレターゼとシナプス機能2008
- Author(s)
  植村健吾、安藤功一、久保田正和、木下彩栄
- Journal Title
  
  Cognition and Dementia 7
  
  Pages: 46-54
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Gamma-secretase and synaptic function2008
- Author(s)
  Kengo, Uemura, Koichi, Ando, Masakazu, Kubota, Ayae, Kinoshita
- Journal Title
  
  Cognition and Dementia 7
  
  Pages: 46-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] γセクレターゼとシナプス機能2008
- Author(s)
  植村健吾、安藤功一、久保田正和、木下彩栄
- Journal Title
  
  Cognition and Dementia 7
  
  Pages: 46-54
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] γセクレターゼとシナプス機能2008
- Author(s)
  植村健吾, 他3名
- Journal Title
  
  Cognition and Dementia 7
  
  Pages: 46-54
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] γセクレターゼとシナプス機能2008
- Author(s)
  植村健吾、安藤功一、久保田正和、木下彩栄
- Journal Title
  
  Cognition and Dementia 7
  
  Pages: 46-54
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] GSK3beta activity modifies the localization and function of presenilin 1.2007
- Author(s)
  Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S,
- Journal Title
  
  J Biol Chem 282
  
  Pages: 15823-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790594
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherinvia down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., & Kinoshita, A.
- Journal Title
  
  Neuroscience 145
  
  Pages: 5-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] GSK3beta activity modifies the localization and function of presenilin12007
- Author(s)
  Uemura, K., Kuzuya, A., Shimozono, Y., Aoyagi, N., Ando, K., Shimohama, S., Kinoshita, A
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 15823-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] GSK3beta activity modifies the localization and function of presenilinl.2007
- Author(s)
  Uemura K., Kuzuya A., Shimozono Y., Aoyagi N., Ando K., Shimohama S., & Kinoshita A.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 15823-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023021
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherinvia down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., & Kinoshita, A.
- Journal Title
  
  Neuroscience 145
  
  Pages: 510-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023021
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura K, Kuzuya A, Aoyagi N, Ando K, Shimozono Y, Ninomiya H, Shimohama S, Kinoshita A
- Journal Title
  
  Neuroscience. 145(1)(5月10日)
- Data Source
  KAKENHI-PROJECT-18790594
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., Kinoshita, A.
- Journal Title
  
  Neuroscience 145
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., & Kinoshita, A.
- Journal Title
  
  Neuroscience 145
  
  Pages: 5-10
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] GSK3beta activity modifies the localization and function of presenilinl.2007
- Author(s)
  Uemura K., Kuzuya A., Shimozono Y., Aoyagi N., Ando K., Shimohama S., & Kinoshita A.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 15823-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H, Shimohama, S., Kinoshita, A.
- Journal Title
  
  Neuroscience 145
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor2007
- Author(s)
  Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., Kinoshita, A
- Journal Title
  
  Neuroscience 145
  
  Pages: 5-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] GSK3beta activity modifies the localization and function of presenilin1.2007
- Author(s)
  Uemura K., Kuzuya A., Shimozono Y., Aoyagi N., Ando K., Shimohama S., & Kinoshita A.
- Journal Title
  
  Journal of Biological Chemistry 282
  
  Pages: 15823-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., Kinoshita, A.
- Journal Title
  
  Neuroscience 145
- Data Source
  KAKENHI-PROJECT-18023021
[Journal Article] Amyloid beta inhibits ectodomain shedding of N-cadherinvia down-regulation of cell-surface NMDA receptor.2007
- Author(s)
  Uemura, K., Kuzuya, A., Aoyagi, N., Ando, K., Shimozono, Y., Ninomiya, H., Shimohama, S., & Kinoshita, A.
- Journal Title
  
  Neuroscience 145
  
  Pages: 510-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin.2006
- Author(s)
  Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H, *Kinoshita A, Shimohama S.
- Journal Title
  
  Biochem Biophys Res Commun. 345
  
  Pages: 951-958
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Modulation of beta-catenin nuclear signaling via epsilon-cleavage of N-cadherin.2006
- Author(s)
  Uemura, K., Kihara T., Kuzuya, A., Okawa, K., Bito H, Ninomiya H, Sugimoto H, Kinoshita, A*, Shimohama S.* (*shared last author)
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 951-958
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Modulation of beta-catenin nuclear signaling via epsilon-cleavage of N-cadherin.2006
- Author(s)
  Uemura, K., Kihara T., Kuzuya, A., Okawa, K., Bito H, Ninomiya H, Sugimoto H, Kinoshita, A*, Shimohama S.* (*shared last author)
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 951-958
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin.2006
- Author(s)
  Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S
- Journal Title
  
  Biochem Biophys Res Commun. 345(3)
  
  Pages: 951-958
- Data Source
  KAKENHI-PROJECT-18790594
[Journal Article] Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.2006
- Author(s)
  Uemura K, Kihara T, Kuzuya A, OKawa K, Nishimoto T, Ninomiya H, Sugimoto H, Kinoshita A, Shimohama S
- Journal Title
  
  Neurosci Lett. 402(3)
  
  Pages: 278-283
- Data Source
  KAKENHI-PROJECT-18790594
[Journal Article] Characterization of N-cadherin cleavage by ADAM10 and Presenilin 1.2006
- Author(s)
  Uemura, K., Kihara T, Kuzuya, A., Okawa, K., Sugimoto H, Kinoshita, A*, Shimohama S.*(*shared last author)
- Journal Title
  
  Neuroscience Letters 402
  
  Pages: 278-283
- Data Source
  KAKENHI-PROJECT-18023021
[Journal Article] Characterization of N-cadherin cleavage by ADAM10 and Presenilin 1.2006
- Author(s)
  Uemura, K., Kihara T, Kuzuya, A., Okawa, K., Sugimoto H, Kinoshita, A*, Shimohama S.* (*shared last author)
- Journal Title
  
  Neuroscience Letters 402
  
  Pages: 278-283
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Characterization of N-cadherin cleavage by ADAM10 and Presenilin 1.2006
- Author(s)
  Uemura, K., Kihara T, Kuzuya, A., Okawa, K., Sugimoto H, Kinoshita, A*, Shimohama S.* (*shared last author)
- Journal Title
  
  Neuroscience Letters 402
  
  Pages: 278-283
- Data Source
  KAKENHI-PROJECT-18059019
[Journal Article] The regulatory mechanism of synaptic protein translation By PS1/gamma-secretase2006
- Author(s)
  Ayae, Kinoshita, Kengo, Uemura, Koichi, Ando
- Journal Title
  
  Seikagaku 78
  
  Pages: 965-972
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Modulation of beta-catenin nuclear signaling via epsilon-cleavage of N-cadherin.2006
- Author(s)
  Uemura, K., Kihara T., Kuzuya, A., Okawa, K., Bito H, Ninomiya H, Sugimoto H, Kinoshita, A*, Shimohama S.* (*shared last author)
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 951-958
- Data Source
  KAKENHI-PROJECT-18023021
[Journal Article] Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin2006
- Author(s)
  Uemura, K., Kihara, T., Kuzuya, A., Okawa, K., Nishimoto, T., Bito, H., Ninomiya, H., Sugimoto, H., Kinoshita, A., Shimohama, S
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 951-958
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] プレセニリン・γセクレターゼによるシナプスタンパク質転写制御機構2006
- Author(s)
  木下彩栄、植村健吾、安藤功一
- Journal Title
  
  生化学 78
  
  Pages: 965-972
- NAID
  10018335119
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Characterization of sequential N-cadherin cleavage by ADAMIO. and PS12006
- Author(s)
  Uemura, K., Kihara, T., Kuzuya, A., Okawa, K., Nishimoto, T., Bito, H., Ninomiya, H., Sugimoto, H., Kinoshita, A., Shimohama, S
- Journal Title
  
  Neurosci Lett 402
  
  Pages: 278-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] Characterization of sequential N-cadherin cleavage by ADAM10 and PSl.2006
- Author(s)
  Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Ninomiya H, Sugimoto H, *Kinoshita A, Shimohama S.
- Journal Title
  
  Neurosci Lett. 402
  
  Pages: 278-283
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500263
[Journal Article] J Neurochemistry N-cadherin enhances APP dimerization at the extracellular domain and modulates Abeta production.
- Author(s)
  Megumi Asada-Utsugi, Kengo Uemura, Yashuha Noda, Akira Kuzuya, Masato Maesako, Koichi Ando, Masakazu Kubota, Kiwamu Watanabe, Makio Takahashi, Takeshi Kihara, Shun Shimohama, Ryosuke Takahashi, Oksana Berezovska, Ayae Kinoshita
- Journal Title
  
  J Neurochemistry(accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Insight into 'synaptopathy' in Alzheimer's disease : From lifestyle to PS1/N-cadherin interaction.
- Author(s)
  Kuzuya A, Kinoshita A, Uemura K.
- Journal Title
  
  Alzheimer's Disease Research Journal 2011 (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Journal Article] Presenilin regulates insulin signaling via gamma-secretase independent mechanism.
- Author(s)
  Masato Maesako, Kengo Uemura, Akira Kuzuya, Megumi Asada, Kazuki Sasaki, Kiwamu Watanabe, Koichi Ando, Masakazu Kubota, Takeshi Kihara, Ayae Kinoshita
- Journal Title
  
  J Biological Chemistry (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] 銅はAPPダイマー化を促進し、アミロイド産生に影響する2012
- Author(s)
  植村健吾他
- Organizer
  日本臨床神経学会
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-23591243
[Presentation] N-カドヘリンはAPPの細胞外ドメインダイマー化を促進し、Abeta産生を促進する2011
- Author(s)
  浅田めぐみ、植村健吾、木下彩栄他
- Organizer
  神経科学会
- Place of Presentation
  (ポスター発表)
- Data Source
  KAKENHI-PROJECT-23591243
[Presentation] Effects of Presenilin 1 phosphorylation on Insulin Receptor2010
- Author(s)
  前迫真人、植村健吾、久保田正和、安藤功一、葛谷聡、山田奈央、浅田めぐみ、秋山治彦、木下彩栄
- Organizer
  神経科学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] Effects of Presenilin 1 phosphorylation on Insulin Receptor.2010
- Author(s)
  前迫真人、植村健吾、久保田正和、安藤功一、葛谷聡、山田奈央、浅田めぐみ、秋山治彦、木下彩栄
- Organizer
  神経科学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] インスリンシグナルがプレセニリンの局在・機能に与える影響の解明2010
- Author(s)
  木下彩栄、前迫真人、浅田めぐみ、葛谷聡、安藤功一、久保田正和、植村健吾、秋山治彦
- Organizer
  日本神経学会総会
- Place of Presentation
  東京
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] Analysis of N-cadherin interacting proteins in Alzheimer's disease.2010
- Author(s)
  Koichi A, Maesako M, Asada M, Aoyagi N, Kubota M, Kuzuya A, Uemura K, Kawamata J, Takahashi R, Kinoshita A
- Organizer
  International Conference of Alzheimer's disease.
- Place of Presentation
  米国ハワイ州
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] Analysis of N-cadherin interacting proteins in Alzheimer's disease2010
- Author(s)
  Koichi A, Maesako M, Asada M, Aoyagi N, Kubota M, Kuzuya A, Uemura K, Kawamata J, Takahashi R, Kinoshita A
- Organizer
  International Conference of Alzheimer's disease
- Place of Presentation
  米国ハワイ州ホノルル
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] APPシスダイマー化におけるN-cadherin、ネクチン1の影響2010
- Author(s)
  浅田めぐみ、植村健吾、葛谷聡、山田奈央、前迫真人、安藤功一、渡辺究、久保田正和、Oksana Berezovska, Brad Hyman, 下浜俊、高橋良輔、木下彩栄
- Organizer
  神経科学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] インスリンシグナルがPS1に与える影響の解明2010
- Author(s)
  前迫真人、植村健吾、佐々木和樹、安藤功一、葛谷聡、浅田めぐみ、久保田正和、秋山治彦、木下彩栄
- Organizer
  日本認知症学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] APPシスダイマー化におけるN-cadherin2010
- Author(s)
  浅田めぐみ、植村健吾、葛谷聡、山田奈央、前迫真人、安藤功一、渡辺究、久保田正和、Oksana Berezovska, Brad Hyman, 下浜俊、高橋良輔、木下彩栄
- Organizer
  ネクチン1の影響神経科学会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] インスリンシグナルを介したプレセニリン1の機能制御2009
- Author(s)
  前迫真人, 植村健吾, 久保田正和, 青柳信寿, 葛谷聡, 安藤功一, 池内健, 浅田めぐみ, 木下彩栄
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] プレセニリンのリン酸化がインスリン受容体の切断に与える影響2009
- Author(s)
  前迫真人, 植村健吾, 久保田正和, 安藤功一, 葛谷聡, 浅田めぐみ, 渡辺拡人, 山田奈央, 秋山治彦, 木下彩栄
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] アルツハイマー病におけるN-カドヘリン関連たんぱく質の解析2009
- Author(s)
  安藤功一, 前迫真人, 浅田めぐみ, 久保田正和, 青柳信寿, 植村健吾, 葛谷聡, 川又純, 高橋良輔, 木下彩栄
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] APPダイマー化におけるN-カドヘリンの影響2009
- Author(s)
  浅田めぐみ, 植村健吾, 葛谷聡, 渡辺拡人, 久保田正和, 下濱俊, 高橋良輔, 木下彩栄
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] 細胞内たんぱく質分解系がPS1によるAPPの切断に及ぼす影響の検討2009
- Author(s)
  渡辺拡人, 葛谷聡, 浅田めぐみ, 植村健吾, 渡辺拡人, 前迫真人, 久保田正和, 高橋良輔, 木下彩栄
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] APPダイマー化に対するN-カドヘリンの影響2009
- Author(s)
  浅田めぐみ, 植村健吾, 葛谷聡, 久保田正和, 下浜俊, 高橋良輔, 木下彩栄
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] N-カドヘリンのプレセニリン・γセクレターセクレターゼ機能に与える影響2008
- Author(s)
  植村健吾, 青柳信寿, 安藤功一, 浅田めぐみ, 下浜俊, 高橋良輔, 木下
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio2008
- Author(s)
  Uemura K, et al.
- Organizer
  11th International Congress of Alzheimer's desease
- Place of Presentation
  Chicago, USA
- Year and Date
  2008-07-28
- Data Source
  KAKENHI-PROJECT-20300124
[Presentation] カドヘリン切断に対するアミロイドβ蛋白の影響2007
- Author(s)
  植村健吾、葛谷聡、青柳信寿、安藤功一、下濱俊、木下彩栄
- Organizer
  第48回日本神経学会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-18023021
[Presentation] Tne N-cadherin enhances extracelluar secretion of Abeta and modulates Ab40/42 ratio2007
- Author(s)
  Uemura, K., Aoyagi, N., Ando, K., Takahashi, R., Shimohama, S., Kinoshita, A
- Organizer
  26th Japan Society for Dementia
- Place of Presentation
  Osaka
- Year and Date
  2007-10-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Presentation] N-cadherin enhances extracellular secretion of Abeta and modulates Abeta42/40 ratio.2007
- Author(s)
  植村健吾、青柳信寿、安藤功一、高橋良輔、下濱俊、木下彩栄
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Year and Date
  2007-10-07
- Data Source
  KAKENHI-PROJECT-18023021
[Presentation] カドヘリン切断に対するアミロイドβ蛋白の影響2007
- Author(s)
  植村健吾、葛谷聡、青柳信寿、安藤功一、下濱俊、木下彩栄
- Organizer
  第48回日本神経学会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-18059019
[Presentation] カドヘリン切断に対するアミロイドβ蛋白の影響2007
- Author(s)
  植村健吾、青柳信寿、安藤功一、高橋良輔、下濱俊、木下彩栄
- Organizer
  第48回日本神経学会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Presentation] N-cadherin enhances extracellular secretion of Abeta and modulates Abeta42/40 ratio.2007
- Author(s)
  植村健吾、青柳信寿、安藤功一、高橋良輔、下濱俊、木下彩栄
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Year and Date
  2007-10-07
- Data Source
  KAKENHI-PROJECT-18059019
[Presentation] N-cadherin enhances extracellular secretion of Abeta and modulates Abeta42/40 ratio2007
- Author(s)
  植村健吾、青柳信寿、安藤功一、高橋良輔、下濱俊、木下彩栄
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-18790594
[Presentation] The effect of amyloid beta protein on cadherin cleavage2007
- Author(s)
  Uemura, K., Aoyagi, N., Ando, K., Takahashi, R., Shimohama, S., Kinoshita, A
- Organizer
  48th Japan Society of Neurologica
- Place of Presentation
  Nagoya
- Year and Date
  2007-05-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Presentation] N-cadherin enhances extracellular secretion of Abeta and modulates Abeta42/40 ratio.2007
- Author(s)
  植村健吾、青柳信寿、安藤功一、高橋良輔、下濱俊、木下彩栄
- Organizer
  第26回日本認知症学会
- Place of Presentation
  大阪
- Year and Date
  2007-10-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500263
[Presentation] カドヘリン切断に対するアミロイドβ蛋白の影響2007
- Author(s)
  植村健吾、葛谷聡、青柳信寿、安藤功一、下濱俊、木下彩栄
- Organizer
  第48回日本神経学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-18790594

1. KINOSHITA Ayae (80321610)

# of Collaborated Projects: 6 results

# of Collaborated Products: 79 results
2. KUBOTA Masakazu (80452267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
3. 伊東秀文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 高橋良輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uemura Kengo 植村 健吾

UEMURA Kengo 植村 健吾

Research Projects

Research Products

Co-Researchers

The examination of AD pathology from the perspective of the astrocyte-neuron interaction: the participation of IGFBP-3 released by astrocytes.Principal Investigator

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abcPrincipal Investigator

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Analysis of the mechanism of pathological synaptic alterations in Alzheimer's disease

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プレセニリン機能障害によるシナプス制御機構の破綻

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プレセニリンを介したカドヘリンーカテニン複合体とシグナル伝達のクロストーク

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アルツハイマー病原因遺伝子プレセリニン機能障害によるシナプス変性機構の解明Principal Investigator

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Investigation of the synaptic dissociation mechanism

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[Journal Article] The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.2015

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[Journal Article] High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.2015

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[Journal Article] Idiopathic Normal Pressure Hydrocephalus has a Different Cerebrospinal Fluid Biomarker Profile from Alzheimer's Disease2014

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[Journal Article] Copper enhances APP dimerization and promotes Aβproduction2013

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[Journal Article] Copper enhances APP dimerization and promotes Aβ production.2013

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[Journal Article] Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.2012

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[Journal Article] Environmental enrichment ameliorated high fat diet-induced Aβdeposition and memory deficit in APP transgenic mice2012

Author(s)

Uemura Kengo 植村健吾

UEMURA Kengo 植村健吾