HAMANA Hiroshi 浜名洋

Researcher Number	00383472
Affiliation (based on the past Project Information) *help	2006 – 2011: 千葉科学大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Biological pharmacy / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 構造活性相関 / NMDA受容体 / アダマンタン / メマンチン / パーキンソン病 / アルツハイマー病 / プロモアダマンタン / MK-801 / 光学活性なアダマンタン / 臭素化 … More / アミノアダマンタン / ネラマキサン / 合成 / ネラメキサム酸 / 治療薬 / 結合測定法 / 抗グルタメート作用 / アマンタジン / アダマンタン骨格 / アルツハイマー / NMDA 受容体 … More Except Principal Investigator アルツハイマー病 / 神経変性疾患 / パーキンソン病 / ケミカルシャペロン / 小胞体ストレス / 細胞死 / 神経変改疾患 / ケミカルシャベロン / Parkin / Aβ / APP / Dorfin / 不溶化 / 構造活性相関 / 酸化ストレス / 神経細胞死 / ユビキチンリガーゼ / ERAD Less

The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery
- Principal Investigator
  
  NOMURA Yasuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Yokohama College of Pharmacy
DEGRADATION OF ABNORMAL PROTEIN/ANTIAGRIGATION SUBSTANCE, REGARDING ENDOPLASMIC RETICULUM ASSOCIATED MOLECULE AS A TARGET OF THERAPEUTIC AGENT ON NEURODEGERERATIVE DISEASE
- Principal Investigator
  
  OKUMA Yasunobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba Institute of Science
Development of new anti-AlzheimerPrincipal Investigator
- Principal Investigator
  
  HAMANA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Chiba Institute of Science
Function of endoplasmic reticulum stress-related molecule, and effects of chemical chaperon involved in neurodegenerative disease
- Principal Investigator
  
  OKUMA Yasunobu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba Institute of Science
Synthesis and mechanism of action of NMDA inhibitor memantine derivativesPrincipal Investigator
- Principal Investigator
  
  HAMANA Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Chiba Institute of Science

All 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Protective effects of 4-PBA(phenylbutyrate) derivatives on the neuronal cell death and endoplasmic reticulum stress2012
- Author(s)
  Mimori, S., Okuma, Y., Kaneko, M., Kawada, K., Hosoi, T., Ozawa, K., Nomura, Y. and Hamana, H.
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35 Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300142
[Journal Article] Protective effects of 4-Phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress2012
- Author(s)
  Seisuke Mimori, Yasunobu Okuma, Masayuki Kaneko, Koichi Kawada, Toru Hosoi, Koichiro Ozawa, Yasuyuki Nomura, Hiroshi Hamana
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35(1) Pages: 84-90
- NAID
  130001872347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590120
[Journal Article] Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress2012
- Author(s)
  Mimori S、Okuma Y、Kaneko M、Kawada K、Hosoi T、Ozawa K、Nomura Y、Hamana H
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 1 Pages: 84-90
- DOI
  10.1248/bpb.35.84
- NAID
  130001872347
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300142, KAKENHI-PROJECT-21590101, KAKENHI-PROJECT-22590100, KAKENHI-PROJECT-23790088, KAKENHI-PROJECT-23790095
[Journal Article] Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain2011
- Author(s)
  Kawada K、Kaneko M、Nomura Y、Mimori S、Hamana H、Ogita K、Murayama T、Fujino H、 Okuma Y
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 117 Issue: 3 Pages: 208-212
- DOI
  10.1254/jphs.11120SC
- NAID
  10030453464
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300142, KAKENHI-PROJECT-21590101, KAKENHI-PROJECT-21590111, KAKENHI-PROJECT-21590120, KAKENHI-PUBLICLY-22020032, KAKENHI-PROJECT-23790095
[Journal Article] Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain2011
- Author(s)
  Kawada, K., Kaneko, M., Nomura, Y., Mimori, S., Hamana, H., Ogita, K., Murayama, T., Fujino, H. and Okuma, Y.
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 117 Pages: 208-212
- NAID
  10030453464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300142
[Journal Article] Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain2011
- Author(s)
  Kawada K, Kaneko, M, Nomura Y, Mimori, S, Hamana, H, Ogita, K, Murayama, T, Fujino, H, Okuma Y
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 117(3) Pages: 208-12
- NAID
  10030453464
- Data Source
  KAKENHI-PROJECT-21590101
[Journal Article] Ca^<2+>Inhibits the Association of Memantine with N-Methyl-D-aspartate(NMDA)Receptor-Gated Ion Channels2008
- Author(s)
  M. Fujimoto, H. Iida, T. Homma, I. Kimura, M. Mori, H. Hamana
- Journal Title
  
  Biological and Phrmaceutical Bulletin 31(9)
  
  Pages: 1813-1815
- NAID
  110006878976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] Ca^<2+> Inhibits the Association of Memantine with N-Methyl-D-aspartate (NMDA) Receptor-Gated Ion Channels2008
- Author(s)
  M. Fujimoto, H. Iida, T. Homma, I. Kimura, M. Mori and H. Hamana,
- Journal Title
  
  Biologica and Phrmaceutical Bulletin 31(9)
  
  Pages: 1813-1815
- NAID
  110006878976
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] An efficient conjugate hydrocyanation of chalcones and related enones with TMSCN under solvent-and additive-free microwave conditions2007
- Author(s)
  H.Iida, T.Moromizato, H.Hamana, K.Matsumoto
- Journal Title
  
  Tetrahedron Letters 48.11
  
  Pages: 2037-2039
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] A Highly Efficient Cyanosilylation of Aldehaydes and Ketones under Microwave,Solvent-free, and Lewis acid-free Conditions2007
- Author(s)
  H.Iida, H.Hamana, K.Matsumoto
- Journal Title
  
  Synthetic Communications 印刷中
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] X-Ray Structures and Molecular Orbital Calculations of 6-phospha-pentacyclo[6.3.1.0^<2,4>.0^<3,7>.0^<5,10>]dodecane 6-Oxides2007
- Author(s)
  K.Matsumoto, M.Toda, H.Iid, H.Hamana, K.Kahehi
- Journal Title
  
  Heterocyclic Communications 13(4)
  
  Pages: 199-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] Nitrogen 14 NMR and correlations of oxidation potentials of dibenzo[a,d]cycl[2.2.3]azines with the corresponding HOMOs:Further evidences for peripheral systems2007
- Author(s)
  K.Matsumoto, H.Iida, S.Mimori, H.Hamana, and T.Uchida
- Journal Title
  
  Heterocycles 73
  
  Pages: 883-889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] is there any effect of pressure on metal cation extraction properties of 7,13-bis(2-'-thiazolyl)-1,4,10-trioxa-7,13-diazacyclopentadecane?2007
- Author(s)
  K.Matsumoto, M.Toda, H.Iida, H.Hamana
- Journal Title
  
  Heterocyclic Communications 13.1
  
  Pages: 13-16
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] An efficient conjugate hydrocyanation of chalcones and related enones with TMSCN under solvent-and additive-free microwave conditions2007
- Author(s)
  H.Iida, T.Moromizato, H.Hamana, and K.Matsumoto
- Journal Title
  
  Tetrahedron Letters 48(11)
  
  Pages: 2037-2039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590104
[Journal Article] Hilbert-Johnson Reaction under High Pressure : A Facile Preparation of 2-Pyridones2007
- Author(s)
  K.Matsumoto, Y.Ikemi, M.Suda, H.Iida, H.Hamana
- Journal Title
  
  Heterocycles 72
  
  Pages: 187-190
- NAID
  40015348799
- Data Source
  KAKENHI-PROJECT-18590104
[Presentation] 経変性疾患治療薬を目指した低分子化合物の合成と評価(2)2012
- Author(s)
  三森盛亮、荒野直紀、藤平幸祐、山森正嗣、溝井健太、川田浩一、金子雅幸、大熊康修、村上泰興、浜名洋
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590101
[Presentation] 経変性疾患治療薬を目指した低分子化合物の合成と評価(2)2012
- Author(s)
  三森盛亮、荒野直紀、藤平幸祐、山森正嗣、溝井健太、川田浩一、金子雅幸、大熊康修、村上泰興、浜名洋
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21300142
[Presentation] 神経変性疾患治療薬を目指した低分子化合物の合成と評価(2)2012
- Author(s)
  三森盛亮, 荒野直紀, 藤平幸祐, 山森正嗣, 溝井健太, 川田浩一, 金子雅幸, 大熊康修, 村上泰興, 浜名洋
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21300142
[Presentation] 神経変性疾患治療薬を目指した低分子化合物の合成と評価(2)2012
- Author(s)
  三森盛亮, 荒野直紀, 藤平幸祐, 山森正嗣, 溝井健太, 川田浩一, 金子雅幸, 大熊康修, 村上泰興, 浜名洋
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590101
[Presentation] ナフタレン誘導体の合成とケミカルシャペロン活性2011
- Author(s)
  三森盛亮、浜名洋, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21590120
[Presentation] Synthesis and Evaluation of Small Molecules for Therapeutic Agents of Neurodegenerative Disease2011
- Author(s)
  三森盛亮、浜名洋, 他
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-21590120
[Presentation] Synthesis and Evaluation of Small Molecules for Therapeutic Agents of Neurodegenerative Disease2011
- Author(s)
  Mimori S、Koshikawa Y、Mizoi K、Saito K、Kaneko M、Okuma Y、Murakami Y、Hamana H
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21300142
[Presentation] A New Synthetic Method of Pyridone and Pyridine Using Intramolecular Hosomi-Sakurai Reaction of Nitriles2011
- Author(s)
  川島裕也、浜名洋, 他
- Organizer
  23^<rd> International Congress on Heterocyclic Chemistry (ICHC2011)
- Place of Presentation
  グラスゴー
- Year and Date
  2011-08-02
- Data Source
  KAKENHI-PROJECT-21590120
[Presentation] Synthesis and Evaluation of Small Molecules for Therapeutic Agents of Neurodegenerative Disease2011
- Author(s)
  Mimori S、Koshikawa Y、Mizoi K、Saito K、Kaneko M、Okuma Y、Murakami Y、Hamana H
- Organizer
  8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
- Place of Presentation
  東京
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21590101
[Presentation] アダマンタンダイマーの合成と細胞増殖への影響2011
- Author(s)
  荒野直紀、浜名洋, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590120
[Presentation] 4-フェニル酪酸誘導体の合成と構造活性相関2010
- Author(s)
  三森盛亮、浜名洋, 他
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-21590120
[Presentation] 4-フェニル酪酸構造類似体の合成と解析2009
- Author(s)
  三森盛亮、飯田博一、清水真希、金子雅幸、田窪裕介、齋藤弓子、池永枝里花、大村友博、大熊康修、浜名洋
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-19590073
[Presentation] 4-フェニル酪酸構造類似体の合成とそのケミカルシャペロン活性の解析2008
- Author(s)
  三森盛亮、飯田博一、五十嵐麻美子、浜名洋、金子雅幸、坪山沙有里、齋藤弓子、大村友博、大熊康修、松本澄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19590073
[Presentation] マイクロ波による合成研究IV:無触媒・無溶媒マイクロ波照射Hilbert-Johnson反応2007
- Author(s)
  飯田博一、雨宮健太、中島閲子、袴塚寛子、諸見里達哉、三森誠亮、浜名洋、松本澄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18590104

1. IIDA Hirokazu (10335797)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. OKUMA Yasunobu (20127939)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. FUJIMOTO Masafumi (30406798)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. NOMURA Yasuyuki (00034041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KANEKO Masayuki (10322827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. SHINOZUKA Tatsuo (70095610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IZUMO Nobuo (70368976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TONOOKA Keiko (20521884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MIMORI Eisuke (70433688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. 松本澄 (20026818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. 友部浩二 (80460286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HAMANA Hiroshi 浜名 洋

Research Projects

Research Products

Co-Researchers

The inhibitory mechanism of unfolded protein accumulation in the endoplasmic reticulum : Studies on anti-neurodegeneration drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEGRADATION OF ABNORMAL PROTEIN/ANTIAGRIGATION SUBSTANCE, REGARDING ENDOPLASMIC RETICULUM ASSOCIATED MOLECULE AS A TARGET OF THERAPEUTIC AGENT ON NEURODEGERERATIVE DISEASE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new anti-AlzheimerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of endoplasmic reticulum stress-related molecule, and effects of chemical chaperon involved in neurodegenerative disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and mechanism of action of NMDA inhibitor memantine derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protective effects of 4-PBA(phenylbutyrate) derivatives on the neuronal cell death and endoplasmic reticulum stress2012

Author(s)

Journal Title

Data Source

[Journal Article] Protective effects of 4-Phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain2011

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Ca^<2+>Inhibits the Association of Memantine with N-Methyl-D-aspartate(NMDA)Receptor-Gated Ion Channels2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Ca^<2+> Inhibits the Association of Memantine with N-Methyl-D-aspartate (NMDA) Receptor-Gated Ion Channels2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] An efficient conjugate hydrocyanation of chalcones and related enones with TMSCN under solvent-and additive-free microwave conditions2007

HAMANA Hiroshi 浜名洋