SHITASHIGE Miki 下重美紀

… Alternative Names

下重美紀シタシゲミキ

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Researcher Number	00392340
Affiliation (based on the past Project Information) *help	2015: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2012 – 2013: 長崎大学, 医学部, 准教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 2011: 独立行政法人国立がん研究センター, 研究所, 主任研究員 2011: 独立行政法人国立がん研究センター, 研究所, 主任研究官 2007: 国立がんセンター研究所及び東病院臨床開発センター, 化学療法部, 研究員 2005 – 2006: 国立がんセンター(研究所及び東病院臨床開発センター), 化学療法部, 研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Biological Sciences / Parasitology (including sanitary zoology) / Surgical dentistry
Keywords	Principal Investigator 遺伝子欠損マウスモデル / 副作用発現予測 / 分子標的治療薬 / 遺伝子欠損マウス Except Principal Investigator pre-mRNA splicing / β-catenin / 大腸がん / 感染 / 免疫制御 / Ｔ細胞 … More / マウス / 制御 / 免疫抑制 / 赤血球 / サイトカイン / マラリア / T細胞 / 抗体スクリーニング / リン酸化タンパク質発現プロファイル / 逆相タンパク質マイクロアレイ / 舌扁平上皮がん / キノームプロファイル / 抗体ライブラリー / 組織マイクロアレイ / 舌がん / 口腔扁平上皮がん / 抗体基盤プロテオミクス / 分子標的治療 / 口腔がん / キノーム / プロテオミクス / 質量分析 / T-cell factor-4 / splicing factor-1 / actinin-4 / splicing factor1(SF1) / Wnt シグナル / 大腸癌 / T-cell factor 4(TCF4) / E-cadherin / 細胞運動 / Actinin-4 / アクチン結合タンパク質 / 転移 Less

Role of novel regulatory T cells in malaria
- Principal Investigator
  
  YUI Katsuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Nagasaki University
Development of novel molecular targets for oral cancer with kinome profile by antibody-based proteomics
- Principal Investigator
  
  Kazufumi Honda
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  National Cancer Center Japan
ＴＮＩＫ遺伝子欠損マウス開発による大腸発がん制御機構解明と標的薬の副作用発現予測Principal Investigator
- Principal Investigator
  
  下重美紀
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
  National Cancer Center Japan
アクチニン4とβカテニンの作用による大腸がんの浸潤転移の分子機構解明
- Principal Investigator
  
  山田哲司
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Actinin-4によるアクチン細胞骨格の制御とがんの浸潤・転移の分子機構の解明
- Principal Investigator
  
  山田哲司
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2013 2012 2011 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] Targeting the Wnt Pathway in Cancer2011
- Author(s)
  Shitashige M, Yamada T. et al.
- Total Pages
  241
- Publisher
  Springer Science+Business Media
- Data Source
  KAKENHI-PROJECT-23590376
[Book] Annual Review呼吸器20072007
- Author(s)
  下重美紀, 他
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.2013
- Author(s)
  Honda K
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 43(2) Issue: 2 Pages: 103-109
- DOI
  10.1093/jjco/hys200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells2012
- Author(s)
  Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, Yamada T
- Journal Title
  
  Gastroenterology
  
  Volume: 42(3) Pages: 572-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] CHFR regulates the mitotic checkpoint via PARP-1.2012
- Author(s)
  Kashima L, Idogawa M, Mita H, Shitashige M. et al.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590376
[Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.2012
- Author(s)
  Satow R
- Journal Title
  
  Gastroenterology
  
  Volume: 142 Issue: 3 Pages: 572-581
- DOI
  10.1053/j.gastro.2011.11.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390197, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130006
[Journal Article] CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation2012
- Author(s)
  Kashima, L., Idogawa, M., Mita, H., Shitashige, M., Yamada, T., Ogi, K., Suzuki, H., Toyota, M., Ariga, H., Sasaki, Y., Tokino, T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Issue: 16 Pages: 12975-12984
- DOI
  10.1074/jbc.m111.321828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390014, KAKENHI-PROJECT-22790654, KAKENHI-PROJECT-22791293, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation.2012
- Author(s)
  Honda K
- Journal Title
  
  PLoS One
  
  Volume: 7(10) Issue: 10 Pages: e46908-e46908
- DOI
  10.1371/journal.pone.0046908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Functional genome survey of RCC.2011
- Author(s)
  Ito H,Honda K,Satow R,Arai E,Shitashige M. et al.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 41 Issue: 7 Pages: 847-853
- DOI
  10.1093/jjco/hyr060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-23790456
[Journal Article] Combined functional genome survey of therapeutic targets tor clear cell carcinoma of the kidney2011
- Author(s)
  Ito H, Honda K, Satow R, Arai E, Shitashige M, Ono M, Sakuma T, Sakano S, Naito K, Matsuyama H, Yamada T
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 41(7) Pages: 847-853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Wnt signaling inside the nucleus2008
- Author(s)
  Shitashige M, Hirohashi S, Yamada T
- Journal Title
  
  Cancer Sci Apr;99(4)
  
  Pages: 631-637
- NAID
  10024004204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Increased susceptibility of Sfl(+/-)mice to azoxymethane-induced colon tumorigenesis2007
- Author(s)
  Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, Yamada T
- Journal Title
  
  Cancer Sci Dec;98(12)
  
  Pages: 1862-1867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Involvement of splicing factor-1 in β-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing2007
- Author(s)
  下重美紀, 他
- Journal Title
  
  Gastroenterology 132(3)
  
  Pages: 1039-1054
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Functional Interaction of DNA Topoisomerase IIα with the S-Catenin and T-Cell Factor-4 Complex2007
- Author(s)
  Huang L, Shitashige M, Satow R, Honda K, Ono M, YunJ I, Tomida A, Tsuruo T, Hirohashi S, Yamada T
- Journal Title
  
  Gastroenterology Nov;133(5)
  
  Pages: 1569-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas
- Author(s)
  Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige K, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J, Hirohashi S, Yamada T
- Journal Title
  
  Clin Cancer Res (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Distinct Gene-expression-defined Classes of Gastrointestinal Stromal Tumor
- Author(s)
  Yamaguchi U, Nakayama R, Honda K, Ichikawa H, Hasegawa T, Shitashige M, Ono M, Shoji A, Sakuma T, Ruwabara H, Shimada Y, Sasako M, Shimoda T, Kawai A, Hirohashi S, Yamada T
- Journal Title
  
  J CIin Oncol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Journal Article] Regulation of Wnt Signaling by the Nuclear Pore Complex.
- Author(s)
  ShitashigeM, Satow R, Honda K, Ono M, Hirohashi S, Y amada T.
- Journal Title
  
  Gastroenterology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013052
[Patent] SCREENIBG METHOD FOR ANTICANCER DRUG.2012
- Inventor(s)
  山田哲司、下重美紀、廣橋説雄
- Industrial Property Rights Holder
  山田哲司、下重美紀、廣橋説雄
- Industrial Property Rights Type
  特許
- Filing Date
  2012-12-04
- Acquisition Date
  2012-12-04
- Overseas
- Data Source
  KAKENHI-PROJECT-23590376
[Patent] NOVEL BICYCLIC THIAZOLE COMPOUNDS.2012
- Inventor(s)
  澤匡明、山田哲司、下重美紀、森山英樹、川瀬裕介、宇野佑子
- Industrial Property Rights Holder
  澤匡明、山田哲司、下重美紀、森山英樹、川瀬裕介、宇野佑子
- Industrial Property Rights Type
  特許
- Filing Date
  2012-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23590376
[Patent] 肝癌特異的発現遺伝子による肝癌の検査方法並びに肝癌の治療及び予防剤2008
- Inventor(s)
  山田哲司、下重美紀、佐藤礼子、廣橋説雄
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Filing Date
  2008-03-12
- Data Source
  KAKENHI-PROJECT-18013052
[Patent] 抗癌剤のスクリーニング法2008
- Inventor(s)
  山田哲司、下重美紀、廣橋説雄
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Filing Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-18013052
[Patent] 大腸がんの治療に用いられる薬物のスクリーニング法2007
- Inventor(s)
  山田哲司、下重美紀、黄琳、他
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Filing Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] beta-catenin Inhibits Promyelocytic Leukemia Protein Tumor Suppressor　Function in Colorectal Cancer Cells.2012
- Author(s)
  Satow R, Shitashige M, Fukami K, Yamada T.
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590376
[Presentation] Identifying new therapeutic targets for personalized medicine2011
- Author(s)
  Yamada T, Honda K, Masuda M, Shitashige M, Ono M
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場、名古屋市
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23390469
[Presentation] 癌の診断・治療や個別化医療に用いる腫瘍マーカーの現状と問題点2011
- Author(s)
  山田哲司、増田万里、下重美紀、尾野雅哉、本田一文
- Organizer
  第31回日本分子腫瘍マーカー研究会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23590376
[Presentation] Identifying new targets for personalized medicine.2011
- Author(s)
  Yamada T, Honda K, Masuda M, Shitashige M, Ono M.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23590376
[Presentation] Actinin-4-mediated inhibition of cell proliferation and mass spectrometry analysis of the native proteincomplex containing actinin-4 inprostate cancer cells2007
- Author(s)
  Tomohiko Hara, Kazufumi Honda, Miki Shitashige, Masaya Ono, Hideyasu Matsuyama, Katsusuke Naito, Setsuo Hirohashi, Tesshi Yamada
- Organizer
  The 98th annual meeting, American Association for Cancer Research
- Place of Presentation
  米国(ロサンゼルス)
- Year and Date
  2007-04-14
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Splicing factorl (SF1) deficiency enhances colon tumorigenesis in mice2007
- Author(s)
  Miki Shitashige, Reiko Satow, Setsuo Hirohashi, Tesshi Yamada
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  神奈川県 (横浜市)
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Large-scale identification of proteins whose expression is regulated by the β-catenin and T-cell factor-4(TCF4) complex in colorectal cancer cells2007
- Author(s)
  Miki Shitashige, Kazufumi Honda, Masaya Ono, Setsuo Hirohashi, and Tesshi Yamada
- Organizer
  The 6th Annual World Congress, HumanProtedme Organization
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Biomarker Discovery by 2-Dimensional Image Converted Analysis of Liquid Chromatography and Mass Spectrometry (2DICAL)2007
- Author(s)
  Ayako Negishi, Masaya Ono, Junichi Matsubara, Emiko Chikui, Kazufumi Honda, Miki Shitashige, Ken Omura, Setsuo Hirohashi, and Tesshi Yamada
- Organizer
  The 6th Annual World Congress, Human Proteome Organization
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2007-10-08
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] I dentification of biomarkers and therapy targets by oncogenomics and oncoproteomcs2007
- Author(s)
  Tesshi Yamada, Kazufumi Honda, Miki Shitashige, Masaya Ono, Setsuo Hirohashi
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  神奈川県(横浜市)
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Whole-genomeexon-level transcriptome survey of human hepatocellular carcinoma2007
- Author(s)
  Reiko Satow, Miki Shitashige, Kazufumi Honda, Yae Kanai, Setsuo Hirohashi, Tesshi Yamada
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  神奈川県(横浜市)
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] プロテオーム解析によるバイオマーカー探索と臨床応用.2007
- Author(s)
  山田哲司、本田一文、下重美紀、尾野雅哉
- Organizer
  第58回目本電気泳動学会総会
- Place of Presentation
  山口県(宇部市)
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Mass spectrometry analysis of the native protein complexcontaining actinin-4 in prostate cancer cells.-Arole of actinin-4protein complex in the intracellular traffickingof cell surface proteins-2007
- Author(s)
  Kazufumi Honda, Miki Shitashige, Masaya Ono, Setsuo Hirohashi, Tesshi Yamada
- Organizer
  The 6th Annual World Congress, Human ProteomeOrganization
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Proteomic analysis of β-catenin-mediated colorectal,carcinogeneses2007
- Author(s)
  Tesshi Yamada, Miki Shitashige, Kazufki Honda, Masaya Ono, Setsuo Hirohashi
- Organizer
  The 6th Annual World Congress, Human Proteme Organizaeion
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-18013052
[Presentation] Peptide alignment of nano-flow liquid chromatography and mass spectrometry(LC-MS) enables large-scale comparisons of the human plasmal proteome2007
- Author(s)
  Masaya Ono, Ayako Negishi, Miki Shitashige, Kazufumi Honda, Setsuo Hirohashi, Tesshi Yamada
- Organizer
  The 6th Annual World Congress, Human Proteome Organization
- Place of Presentation
  韓国(ソウル)
- Year and Date
  2007-10-09
- Data Source
  KAKENHI-PROJECT-18013052

1. Kazufumi Honda (10260936)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
2. Sekine Shigeki (10321879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山田哲司 (30221659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. MORI Taisuke (00296708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HIRAOKA Nobuyoshi (40276217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. WATABE Yukio (50733490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IZUMO Toshiyuki (80322709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YUI Katsuyuki (90274638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KIMURA Daisuke (50423637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOSHIDA Hiroki (40260715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 尾野雅哉 (00270900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
12. 八木原一博 (00538126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 有賀寛芳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHITASHIGE Miki 下重 美紀

下重 美紀 シタシゲ ミキ

Research Projects

Research Products

Co-Researchers

Role of novel regulatory T cells in malaria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel molecular targets for oral cancer with kinome profile by antibody-based proteomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ＴＮＩＫ遺伝子欠損マウス開発による大腸発がん制御機構解明と標的薬の副作用発現予測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アクチニン4とβカテニンの作用による大腸がんの浸潤転移の分子機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Actinin-4によるアクチン細胞骨格の制御とがんの浸潤・転移の分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Targeting the Wnt Pathway in Cancer2011

Author(s)

Total Pages

Publisher

Data Source

[Book] Annual Review呼吸器20072007

Author(s)

Publisher

Data Source

[Journal Article] Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells2012

Author(s)

Journal Title

Data Source

[Journal Article] CHFR regulates the mitotic checkpoint via PARP-1.2012

Author(s)

Journal Title

Data Source

[Journal Article] β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CHFR regulates the mitotic checkpoint by targeting PARP-1 for ubiquitination and degradation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional genome survey of RCC.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined functional genome survey of therapeutic targets tor clear cell carcinoma of the kidney2011

Author(s)

Journal Title

SHITASHIGE Miki 下重美紀

下重美紀シタシゲミキ

[Presentation] beta-catenin Inhibits Promyelocytic Leukemia Protein Tumor Suppressor　Function in Colorectal Cancer Cells.2012