Ohishi Kohshi 大石晃嗣

… Alternative Names

OHISHI Kohshi 大石晃嗣

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Researcher Number	00397506
Other IDs
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2025: 三重大学, 医学部附属病院, 准教授 2018 – 2023: 三重大学, 医学部附属病院, 准教授 2013 – 2015: 三重大学, 医学部附属病院, 准教授 2009 – 2011: Mie University, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator LFA-1 / ストローマ細胞 / 樹状細胞 / リンパ球系分化 / human / B / リンパ球分化 / lymphopoiesis / Bリンパ球 / 腫瘍化 … More / 樹状細胞分化 / ヒト / c-kit / NK細胞 / B細胞 / Bリンパ球系細胞 / IL-7受容体 / 形質細胞様樹状細胞 / ヒトリンパ球系分化 / Dendiritic cell / Notch / B1B 細胞 / differentiation model / fluctutation / scRNAseq / plasmacytoid DC / lymphoid differentaition / リンパ球系細胞分化 / SDF-1 / thrombopoietin / ProT cell / ProB cell / stromal cell / differentiation / cord blood / hematopoiesis / T/NK cell precursors / ProB cells / stromal cells / NKリンパ球分化 / 細胞接着 / thombopoietin / stem cell factor / flt3 ligand / Tリンパ球分化 / Bリンパ球分化 / ヒト骨髄ストローマ細胞 / 分化 / Tリンパ球 … More Except Principal Investigator エクソソーム / 多血小板血漿 / 椎間板再生 Less

Notch非依存性ヒトT前駆細胞分化及びそれ由来単球系/自然リンパ球の特性解明Principal Investigator
- Principal Investigator
  
  大石晃嗣
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
Intervertebral disc regeneration using platelet-rich plasma (PRP)-derived exosomes
- Principal Investigator
  
  明田浩司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Mie University
Biological role and differentiation mechanism of lymphoid-origin dendritic cells and B1B cellsPrincipal Investigator
- Principal Investigator
  
  Ohishi Kohshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
Study of human lymphopoiesis and neoplastic transformation with novel culture systemPrincipal Investigator
- Principal Investigator
  
  Ohishi Kohshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
Role of bone marrow niche in human early lymphopoiesisPrincipal Investigator
- Principal Investigator
  
  Ohishi Kohshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
Understanding of mechanism of human lymphopoiesis and clinical application to cell therapyPrincipal Investigator
- Principal Investigator
  
  OHISHI Kohshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University

All 2020 2019 2018 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

[Book] 血液内科2013
- Author(s)
  大石晃嗣、門間文彦、片山直之
- Publisher
  科学評論者
- Data Source
  KAKENHI-PROJECT-25461447
[Journal Article] A novel FOXP1-PDGFRA fusion gene in myeloproliferative neoplasm with eosinophilia2015
- Author(s)
  Sugimoto Y, Sada A, Shimokariya Y, Monma F, Ohishi K, Masuya M, Nobori T, Matsui T, Katayama N
- Journal Title
  
  Cancer Genet
  
  Volume: 208 Issue: 10 Pages: 508-512
- DOI
  10.1016/j.cancergen.2015.07.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461447
[Journal Article] Adoptive transfer of MAGE-A4 T-cell receptor gene-transduced lymphocytes in patients with recurrent esophageal cancer2015
- Author(s)
  Kageyama S, Ikeda H, Miyahara Y, Imai N, Ishihara M, Saito K, Sugino S, Ueda S, Ishikawa T, Kokura S, Naota H, Ohishi K, Shiraishi T, Inoue N, Tanabe M, Kidokoro T, Yoshioka H, Tomura D, Nukaya I, Mineno J, Takesako K, Katayama N, Shiku H.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: in press Issue: 10 Pages: 2268-2277
- DOI
  10.1158/1078-0432.ccr-14-1559
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591939, KAKENHI-PROJECT-25350612, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-15K10093, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-25461447
[Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.2014
- Author(s)
  Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1371/journal.pone.0084889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013
- Author(s)
  Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
- Journal Title
  
  Exp Hematol
  
  Volume: - Issue: 4 Pages: 367-376
- DOI
  10.1016/j.exphem.2012.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390206, KAKENHI-PROJECT-23300354, KAKENHI-PROJECT-24591390, KAKENHI-PROJECT-24659494, KAKENHI-PUBLICLY-25118712, KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
[Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : A principal role for flt3 ligand in lymphopoiesis2012
- Author(s)
  Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
- Journal Title
  
  British Journal of haematology
  
  Volume: (In Press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors A principal role for flt3 ligand in lymphopoiesis2012
- Author(s)
  Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
- Journal Title
  
  Br J Haematol
  
  Volume: 157(6) Pages: 674-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis2010
- Author(s)
  Liu B, Ohishi K, Yamamura K, Suzuki K, Monma F, Ino K, Nishii K, Masuya M, Sekine T, Heike Y, Takaue Y, Katayama N
- Journal Title
  
  Exp Hematol
  
  Volume: 38 Pages: 685-695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated meoakaryopoiesis and erythropoiesis.2010
- Author(s)
  Liu B, Ohishi K, et al.
- Journal Title
  
  Exp Hematol
  
  Volume: 38 Pages: 685-695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Journal Article] Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia.2010
- Author(s)
  Nakamura A, Sugimoto Y, Ohishi K, et al.
- Journal Title
  
  J Clin Microbiol.
  
  Volume: 48 Pages: 2030-2036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Journal Article] Effect of washing solution on platelet counts following transfusion with twice-washed platelets : a single-patient experience.2010
- Author(s)
  Tanaka Y, Ohishi K, et al.
- Journal Title
  
  Transfus Med.
  
  Volume: 20 Pages: 358-360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] ヒトリンパ系分化路におけるproBとpDCの新たな関連性についての検討2020
- Author(s)
  永春圭規、大石晃嗣、片山直之
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08322
[Presentation] Novel lymphoid pathway of human dendritic cells2019
- Author(s)
  Keiki Nagaharu, Kohshi Ohishi, Naoyuki Katayama
- Organizer
  The 10th JSH international symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08322
[Presentation] ヒト形質細胞様樹状細胞の分化におけるストローマ細胞の役割2018
- Author(s)
  永春圭規、南博仁、大石晃嗣、片山直之
- Organizer
  第１０回血液疾患免疫療法学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08322
[Presentation] Stromal cell-derived factor-1 plays important roles in the regulation of human early B- and T/NK-lineage lymphoid differentaition in different manners2015
- Author(s)
  Hirohito Minami, Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
- Organizer
  20th European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] SDF-1 is involved in human early B- and T/NK-lineage lymphoid differentiation in a different manner2015
- Author(s)
  Hirohito Minami, Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
- Organizer
  第77回日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] LFA-1-Mediated Adhesion to ICAM-2 Is Critical for Stromal Cell-Dependent Early T-Lymphoid Differentiation from Human Hematopoietic Precursors2015
- Author(s)
  Hirohito Minami,Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
- Organizer
  57th American Society of Hematology Annual Meeting
- Place of Presentation
  Orlando, Florida, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] ヒトリンパ球の初期分化制御におけるヒト骨髄ストローマ細胞の役割2013
- Author(s)
  南　博仁, 大石　晃嗣, 中森　良樹, 鈴木　圭, 桝屋　正浩, 片山　直之
- Organizer
  第７５回日本血液学会総会
- Place of Presentation
  さっぽろ芸文館
- Invited
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] ROLE OF BONE MARROW STROMAL CELLS IN THE REGULATION OF HUMAN EARLY LYMPHOPOIESIS2013
- Author(s)
  Ohishi K, Nakamori Y, Katayama N
- Organizer
  The 18th Congress of European Hematology Association
- Place of Presentation
  Stockholm, Sweden
- Invited
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] LFA-1-Mediated Adhesion Of Human Hematopoietic Progenitors To Bone Marrow Stromal Cells Enhances B-Lineage Differentiation Toward CD19+ ProB Cells, While The Generation Of CD7+CD56-CD45RA+ Multipotent Lymphoid and CD10+CD19- B-Biased Progenitors Is Supported By Soluble Factors Produced From Stromal Cells2013
- Author(s)
  Minami H, Ohishi K, Nakamori Y, Masuya M, Katayama N
- Organizer
  55th ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] ヒトB・Tリンパ球系細胞初期分化におけるヒトストローマ細胞の役割2013
- Author(s)
  大石晃嗣、片山直之
- Organizer
  第７２回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25461447
[Presentation] Evaluation of Role for flt3L in Human Early B and T/NK Lymphopoiesis in a Novel Stromal Cell Culture System2011
- Author(s)
  Nakamori Y, Ohishi K, Liu B, Masuya M, Mamada H, Katayama N
- Organizer
  53^<rd> ASH annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Evaluation of role for flt3 ligand in human lymphopoiesis with telomerized human stromal cells2011
- Author(s)
  中森良樹大石晃嗣劉氷桝屋正浩濱田洋文片山直之
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Evaluation of Role for flt3L in Human Early B and T/NK Lymphopoiesis in a Novel Stromal Cell Culture System2011
- Author(s)
  Nakamori Y, Ohishi K, Liu B, Masuya M, Hamada H, Katayama N
- Organizer
  53rd ASH annual Meeting and Exposition
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Important role for flt3 Ligand in the generation of early B and T cell precursors from human primitive hematopoietic progenitors, revealed by telomerized human stromal cells.2010
- Author(s)
  Liu B, Ohishi K, Masuya M, Hamada H, Katayama N
- Organizer
  54nd American Society of Hematology Meeting
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Important role for flt3 Ligand in the generation of early B and T cell precursors from human primitive hematopoietic progenitors, revealed by telomerized human stromal cells2010
- Author(s)
  Liu B, Ohishi K, Masuya M, Hamada H, Katayama N
- Organizer
  54nd American Society of Hematology Meeting
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Crucial role of flt3 ligand in human early B/T lymphopoiesis revealed by telomerized stromal cells2009
- Author(s)
  Liu B, Ohishi K, Suzuki K, Masuya M, Hamada H, Nishikawa H, Shiku H, and Katayama N
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] HDAC inhibitors exert stimulatory effects on human megakaryopoiesis or erythropoiesis in the presence of IL-3 or GM-CSF2009
- Author(s)
  Ohishi K
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Valproic acid, in combination with IL-3, stimulates human megakaryopoiesis as well as erythropoiesis2009
- Author(s)
  Ryuu H, Ohishi K, et al
- Organizer
  第71回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Evaluation of potential role for Valproic Acid in IL-3-mediated megakaryopoiesis and erythropoiesis in serum-free and serum-containing cultures2009
- Author(s)
  Ohishi K, Liu B, Masuya M, Heike Y, Takaue Y, Katayama N
- Organizer
  51st ASH Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Evaluation of potential role for Valproic Acid in IL-3-mediated megakary opoiesis and erythropoiesis in serum-free and serum-containing cultures2009
- Author(s)
  Ohishi K, et al
- Organizer
  51st ASH Annual Meeting
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-21591240
[Presentation] Important role for LFA-1 in early stage of human T lymphopoiesis
- Author(s)
  Minami F, Ohishi K, Nakamori Y, Masuya M, Katayama N
- Organizer
  日本血液学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25461447

1. NOSAKA Tetsuya (30218309)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. NISHIKAWA Hiroyoshi (10444431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. Tawara Isao (80378380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 永春圭規 (80883462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 明田浩司 (20422826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 島岡要 (40281133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 須藤啓広 (60196904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASUYA Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 影山慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小埜良一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohishi Kohshi 大石 晃嗣

OHISHI Kohshi 大石 晃嗣

Research Projects

Research Products

Co-Researchers

Notch非依存性ヒトT前駆細胞分化及びそれ由来単球系/自然リンパ球の特性解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intervertebral disc regeneration using platelet-rich plasma (PRP)-derived exosomes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological role and differentiation mechanism of lymphoid-origin dendritic cells and B1B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of human lymphopoiesis and neoplastic transformation with novel culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of bone marrow niche in human early lymphopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding of mechanism of human lymphopoiesis and clinical application to cell therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 血液内科2013

Author(s)

Publisher

Data Source

[Journal Article] A novel FOXP1-PDGFRA fusion gene in myeloproliferative neoplasm with eosinophilia2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adoptive transfer of MAGE-A4 T-cell receptor gene-transduced lymphocytes in patients with recurrent esophageal cancer2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : A principal role for flt3 ligand in lymphopoiesis2012

Author(s)

Journal Title

Data Source

[Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors A principal role for flt3 ligand in lymphopoiesis2012

Author(s)

Journal Title

Data Source

[Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis2010

Author(s)

Journal Title

Data Source

[Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated meoakaryopoiesis and erythropoiesis.2010

Author(s)

Journal Title

Ohishi Kohshi 大石晃嗣

OHISHI Kohshi 大石晃嗣

[Presentation] ヒトリンパ系分化路におけるproBとpDCの新たな関連性についての検討2020