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Ohishi Kohshi  大石 晃嗣

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OHISHI Kohshi  大石 晃嗣

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Researcher Number 00397506
Other IDs
Affiliation (Current) 2025: 三重大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help 2025: 三重大学, 医学部附属病院, 准教授
2018 – 2023: 三重大学, 医学部附属病院, 准教授
2013 – 2015: 三重大学, 医学部附属病院, 准教授
2009 – 2011: Mie University, 医学部附属病院, 講師
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Hematology
Except Principal Investigator
Basic Section 56020:Orthopedics-related
Keywords
Principal Investigator
LFA-1 / ストローマ細胞 / 樹状細胞 / リンパ球系分化 / human / B / リンパ球分化 / lymphopoiesis / Bリンパ球 / 腫瘍化 … More / 樹状細胞分化 / ヒト / c-kit / NK細胞 / B細胞 / Bリンパ球系細胞 / IL-7受容体 / 形質細胞様樹状細胞 / ヒトリンパ球系分化 / Dendiritic cell / Notch / B1B 細胞 / differentiation model / fluctutation / scRNAseq / plasmacytoid DC / lymphoid differentaition / リンパ球系細胞分化 / SDF-1 / thrombopoietin / ProT cell / ProB cell / stromal cell / differentiation / cord blood / hematopoiesis / T/NK cell precursors / ProB cells / stromal cells / NKリンパ球分化 / 細胞接着 / thombopoietin / stem cell factor / flt3 ligand / Tリンパ球分化 / Bリンパ球分化 / ヒト骨髄ストローマ細胞 / 分化 / Tリンパ球 … More
Except Principal Investigator
エクソソーム / 多血小板血漿 / 椎間板再生 Less
  • Research Projects

    (6 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (10 People)
  •  Notch非依存性ヒトT前駆細胞分化及びそれ由来単球系/自然リンパ球の特性解明Principal Investigator

    • Principal Investigator
      大石 晃嗣
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Mie University
  •  Intervertebral disc regeneration using platelet-rich plasma (PRP)-derived exosomes

    • Principal Investigator
      明田 浩司
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Mie University
  •  Biological role and differentiation mechanism of lymphoid-origin dendritic cells and B1B cellsPrincipal Investigator

    • Principal Investigator
      Ohishi Kohshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Mie University
  •  Study of human lymphopoiesis and neoplastic transformation with novel culture systemPrincipal Investigator

    • Principal Investigator
      Ohishi Kohshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Mie University
  •  Role of bone marrow niche in human early lymphopoiesisPrincipal Investigator

    • Principal Investigator
      Ohishi Kohshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University
  •  Understanding of mechanism of human lymphopoiesis and clinical application to cell therapyPrincipal Investigator

    • Principal Investigator
      OHISHI Kohshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Mie University

All 2020 2019 2018 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] 血液内科2013

    • Author(s)
      大石晃嗣、門間文彦、片山直之
    • Publisher
      科学評論者
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Journal Article] A novel FOXP1-PDGFRA fusion gene in myeloproliferative neoplasm with eosinophilia2015

    • Author(s)
      Sugimoto Y, Sada A, Shimokariya Y, Monma F, Ohishi K, Masuya M, Nobori T, Matsui T, Katayama N
    • Journal Title

      Cancer Genet

      Volume: 208 Issue: 10 Pages: 508-512

    • DOI

      10.1016/j.cancergen.2015.07.001

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461447
  • [Journal Article] Adoptive transfer of MAGE-A4 T-cell receptor gene-transduced lymphocytes in patients with recurrent esophageal cancer2015

    • Author(s)
      Kageyama S, Ikeda H, Miyahara Y, Imai N, Ishihara M, Saito K, Sugino S, Ueda S, Ishikawa T, Kokura S, Naota H, Ohishi K, Shiraishi T, Inoue N, Tanabe M, Kidokoro T, Yoshioka H, Tomura D, Nukaya I, Mineno J, Takesako K, Katayama N, Shiku H.
    • Journal Title

      Clinical Cancer Research

      Volume: in press Issue: 10 Pages: 2268-2277

    • DOI

      10.1158/1078-0432.ccr-14-1559

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591939, KAKENHI-PROJECT-25350612, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-15K10093, KAKENHI-PROJECT-15H04918, KAKENHI-PROJECT-25461447
  • [Journal Article] Monocytes infiltrate the pancreas via the MCP-1/CCR2 pathway and differentiate into stellate cells.2014

    • Author(s)
      Ino K, Masuya M, Tawara I, Miyata E, Oda K, Nakamori Y, Suzuki K, Ohishi K, Katayama N.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1371/journal.pone.0084889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
  • [Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013

    • Author(s)
      Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
    • Journal Title

      Exp Hematol

      Volume: - Issue: 4 Pages: 367-376

    • DOI

      10.1016/j.exphem.2012.12.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390206, KAKENHI-PROJECT-23300354, KAKENHI-PROJECT-24591390, KAKENHI-PROJECT-24659494, KAKENHI-PUBLICLY-25118712, KAKENHI-PROJECT-25460951, KAKENHI-PROJECT-25461413, KAKENHI-PROJECT-25461447
  • [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors : A principal role for flt3 ligand in lymphopoiesis2012

    • Author(s)
      Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
    • Journal Title

      British Journal of haematology

      Volume: (In Press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Journal Article] Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors A principal role for flt3 ligand in lymphopoiesis2012

    • Author(s)
      Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N
    • Journal Title

      Br J Haematol

      Volume: 157(6) Pages: 674-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated megakaryopoiesis and erythropoiesis2010

    • Author(s)
      Liu B, Ohishi K, Yamamura K, Suzuki K, Monma F, Ino K, Nishii K, Masuya M, Sekine T, Heike Y, Takaue Y, Katayama N
    • Journal Title

      Exp Hematol

      Volume: 38 Pages: 685-695

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Journal Article] A potential activity of valproic acid in the stimulation of interleukin-3-mediated meoakaryopoiesis and erythropoiesis.2010

    • Author(s)
      Liu B, Ohishi K, et al.
    • Journal Title

      Exp Hematol

      Volume: 38 Pages: 685-695

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Journal Article] Diagnostic value of PCR analysis of bacteria and fungi from blood in empiric-therapy-resistant febrile neutropenia.2010

    • Author(s)
      Nakamura A, Sugimoto Y, Ohishi K, et al.
    • Journal Title

      J Clin Microbiol.

      Volume: 48 Pages: 2030-2036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Journal Article] Effect of washing solution on platelet counts following transfusion with twice-washed platelets : a single-patient experience.2010

    • Author(s)
      Tanaka Y, Ohishi K, et al.
    • Journal Title

      Transfus Med.

      Volume: 20 Pages: 358-360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] ヒトリンパ系分化 路におけるproBとpDCの新たな関連性についての検討2020

    • Author(s)
      永春圭規、大石晃嗣、片山直之
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08322
  • [Presentation] Novel lymphoid pathway of human dendritic cells2019

    • Author(s)
      Keiki Nagaharu, Kohshi Ohishi, Naoyuki Katayama
    • Organizer
      The 10th JSH international symposium 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08322
  • [Presentation] ヒト形質細胞様樹状細胞の分化におけるストローマ細胞の役割2018

    • Author(s)
      永春圭規、南博仁、大石晃嗣、片山直之
    • Organizer
      第10回血液疾患免疫療法学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08322
  • [Presentation] Stromal cell-derived factor-1 plays important roles in the regulation of human early B- and T/NK-lineage lymphoid differentaition in different manners2015

    • Author(s)
      Hirohito Minami, Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
    • Organizer
      20th European Hematology Association
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-06-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] SDF-1 is involved in human early B- and T/NK-lineage lymphoid differentiation in a different manner2015

    • Author(s)
      Hirohito Minami, Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
    • Organizer
      第77回 日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] LFA-1-Mediated Adhesion to ICAM-2 Is Critical for Stromal Cell-Dependent Early T-Lymphoid Differentiation from Human Hematopoietic Precursors2015

    • Author(s)
      Hirohito Minami,Kohshi Ohishi, Masahiro Masuya, Naoyuki Katayama
    • Organizer
      57th American Society of Hematology Annual Meeting
    • Place of Presentation
      Orlando, Florida, USA
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] ヒトリンパ球の初期分化制御におけるヒト骨髄ストローマ細胞の役割2013

    • Author(s)
      南 博仁, 大石 晃嗣, 中森 良樹, 鈴木 圭, 桝屋 正浩, 片山 直之
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      さっぽろ芸文館
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] ROLE OF BONE MARROW STROMAL CELLS IN THE REGULATION OF HUMAN EARLY LYMPHOPOIESIS2013

    • Author(s)
      Ohishi K, Nakamori Y, Katayama N
    • Organizer
      The 18th Congress of European Hematology Association
    • Place of Presentation
      Stockholm, Sweden
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] LFA-1-Mediated Adhesion Of Human Hematopoietic Progenitors To Bone Marrow Stromal Cells Enhances B-Lineage Differentiation Toward CD19+ ProB Cells, While The Generation Of CD7+CD56-CD45RA+ Multipotent Lymphoid and CD10+CD19- B-Biased Progenitors Is Supported By Soluble Factors Produced From Stromal Cells2013

    • Author(s)
      Minami H, Ohishi K, Nakamori Y, Masuya M, Katayama N
    • Organizer
      55th ASH Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] ヒトB・Tリンパ球系細胞初期分化におけるヒトストローマ細胞の役割2013

    • Author(s)
      大石晃嗣、片山直之
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-25461447
  • [Presentation] Evaluation of Role for flt3L in Human Early B and T/NK Lymphopoiesis in a Novel Stromal Cell Culture System2011

    • Author(s)
      Nakamori Y, Ohishi K, Liu B, Masuya M, Mamada H, Katayama N
    • Organizer
      53^<rd> ASH annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Evaluation of role for flt3 ligand in human lymphopoiesis with telomerized human stromal cells2011

    • Author(s)
      中森良樹大石晃嗣劉氷桝屋正浩濱田洋文片山直之
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Evaluation of Role for flt3L in Human Early B and T/NK Lymphopoiesis in a Novel Stromal Cell Culture System2011

    • Author(s)
      Nakamori Y, Ohishi K, Liu B, Masuya M, Hamada H, Katayama N
    • Organizer
      53rd ASH annual Meeting and Exposition
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Important role for flt3 Ligand in the generation of early B and T cell precursors from human primitive hematopoietic progenitors, revealed by telomerized human stromal cells.2010

    • Author(s)
      Liu B, Ohishi K, Masuya M, Hamada H, Katayama N
    • Organizer
      54nd American Society of Hematology Meeting
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Important role for flt3 Ligand in the generation of early B and T cell precursors from human primitive hematopoietic progenitors, revealed by telomerized human stromal cells2010

    • Author(s)
      Liu B, Ohishi K, Masuya M, Hamada H, Katayama N
    • Organizer
      54nd American Society of Hematology Meeting
    • Place of Presentation
      Orland, FL, USA
    • Year and Date
      2010-12-05
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Crucial role of flt3 ligand in human early B/T lymphopoiesis revealed by telomerized stromal cells2009

    • Author(s)
      Liu B, Ohishi K, Suzuki K, Masuya M, Hamada H, Nishikawa H, Shiku H, and Katayama N
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] HDAC inhibitors exert stimulatory effects on human megakaryopoiesis or erythropoiesis in the presence of IL-3 or GM-CSF2009

    • Author(s)
      Ohishi K
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Valproic acid, in combination with IL-3, stimulates human megakaryopoiesis as well as erythropoiesis2009

    • Author(s)
      Ryuu H, Ohishi K, et al
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Evaluation of potential role for Valproic Acid in IL-3-mediated megakaryopoiesis and erythropoiesis in serum-free and serum-containing cultures2009

    • Author(s)
      Ohishi K, Liu B, Masuya M, Heike Y, Takaue Y, Katayama N
    • Organizer
      51st ASH Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Evaluation of potential role for Valproic Acid in IL-3-mediated megakary opoiesis and erythropoiesis in serum-free and serum-containing cultures2009

    • Author(s)
      Ohishi K, et al
    • Organizer
      51st ASH Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Data Source
      KAKENHI-PROJECT-21591240
  • [Presentation] Important role for LFA-1 in early stage of human T lymphopoiesis

    • Author(s)
      Minami F, Ohishi K, Nakamori Y, Masuya M, Katayama N
    • Organizer
      日本血液学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-25461447
  • 1.  NOSAKA Tetsuya (30218309)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  NISHIKAWA Hiroyoshi (10444431)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  Tawara Isao (80378380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  永春 圭規 (80883462)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  明田 浩司 (20422826)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  島岡 要 (40281133)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  須藤 啓広 (60196904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MASUYA Masahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  影山 慎一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  小埜 良一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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