HASEGAWA Hiroo 長谷川寛雄

Researcher Number	00398166
Other IDs
Affiliation (Current)	2025: 長崎大学, 病院(医学系), 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 長崎大学, 病院(医学系), 准教授 2017: 長崎大学, 医学部, 准教授 2015 – 2017: 長崎大学, 病院(医学系), 講師 2011 – 2013: 長崎大学, 大学病院, 講師 2011: 長崎大学, 病院, 講師 … More 2011: 長崎大学, 長崎大学病院, 講師 2009 – 2010: 長崎大学, 医歯薬学総合研究科, 助教 2007 – 2010: Nagasaki University, Graduate School of Biomedical Sciences, Research Associate 2007: Nagasaki University, 大学院・医歯薬学総舗究科, 助教 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手 2006: 長崎大学, 大学院医歯薬学総合研究科, 助教 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Applied pharmacology / Laboratory medicine Except Principal Investigator Laboratory medicine / Tumor biology / Tumor diagnostics / Applied pharmacology
Keywords	Principal Investigator HTLV-1 / ATL / 遺伝子検査 / 組み込み部位 / 成人T細胞白血病 / 組込み部位 / 成人T 細胞白血病 / クロナリティ検査 / 発症クローン / 成人T細胞白血病・リンパ腫（ATL） … More / バイオマーカー / 遺伝子発現解析 / 表面抗原 / 分子標的 / 細胞株 / 抗ウィルス薬 / 新規抗がん剤 / 分子標的治療薬 / 抗HTLV-1薬 / 天然物質 / 天然由来物質 / TRAIL / 分子標的薬 / 成人T細胞白血病・リンパ腫 / アポトーシス / 分子標的治療 … More Except Principal Investigator p53 / HTLV-1 / HTLV / Mdm2 / ATL / マウスモデル / ATLL / ATL発症原因遺伝子 / 実験動物 / 実験動物モデル / 腫瘍検査・診断 / 腫瘍マーカー / HTLV-1変異解析 / HTLV-1挿入部位解析 / ATLリスク評価法 / 腫瘍診断学 / RAISING / 成人T細胞白血病 / クロナリティ / HTLV-1挿入部位 / HTLV-1変異 / ATLL患者 / HAM/TSP患者 / キャリア / バイオテクノロジー / ウィルス / ゲノム / 癌 / 遺伝子 / 遺伝子増幅 / レンチウイルスベクター / アデノ随伴ウイルスベクター / レンチウイルス / 自己削除型ベクター / 「自己削除型」レンチウイルスベクター / 遺伝子ノックアウト / 遺伝子治療 / CRISPR/Cas9 / AAV(アデノ随伴ウイルスベクター)ベクター / 自己削除型レンチウイルスベクター / ゲノム編集 / Malignancy / Proteasome / Ubiauitin / 悪性腫瘍 / プロテアソーム / ユビキチン / 個性化治療 / 血漿核酸 / EZH2 / 癌治療標的分子 / がんシグナル / 個別化治療 / miR155 / microRNA / 癌治療標的 / Ras / 遺伝子検査 / oncogenomics / IFN-r / Genediagnostics / IL28B / Bio-marker / SNP / Genomic Test / 分子標的療法 / IL-28B / 個別化医療 / 腫瘍検査学 / アポトーシス / ATM / Hzf / 放射線 / 臨床検査医学 / laboratory test / phagocyte / laboratory / Treg cell / dendritic cell / immunology Less

Establishment of a new test method detecting HTLV-1 clonality for capture the onset of ATLPrincipal Investigator
- Principal Investigator
  
  長谷川寛雄
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
Establishment of individualized test method for HTLV-1 carriers based on identification and analysis of ATL-onset clonesPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
Development of ATLL and B-cell lymphoma risk assesment method
- Principal Investigator
  
  Saito Masumichi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institute of Infectious Diseases
Development of gene therapy using self-destructive lentivirus vectors
- Principal Investigator
  
  HAYASHI Hideki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
Exploration new biomarkers based on HTLV-1 carrier clone analysisPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Identification of ATLL-associated genes in Rapid ATLL model mouse
- Principal Investigator
  
  Saito Masumichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  National Institute of Infectious Diseases
Possibility of a new synthetics from lamellarins: anti-leukemic and integrase-inhibitory effects against HTLV-1-related leukemia cells.Principal Investigator
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
Development of Pharmacogenomics in Clinical Oncology
- Principal Investigator
  
  KAMIHIRA Shimeru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
がん治療標的分子は血漿にUbiquitousか
- Principal Investigator
  
  上平憲
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Establishment of a new laboratory test for radiation sensitivity targeting p53 signal transduction system
- Principal Investigator
  
  YAMADA Yasuaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Natural compounds that enhance TRAIL-induced apoptosis : a novel molecular targeted cancer therapyPrincipal Investigator
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
免疫学的チューター、樹状細胞による新免疫機能検査
- Principal Investigator
  
  上平憲
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Establishment of a laboratory system for the analysis of ubiquitin-proteasome pathway in malignancy
- Principal Investigator
  
  YAMADA Yasuaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University

[Journal Article] Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations2023
- Author(s)
  Kuramitsu M, Momose H, Uchida Y, Ishitsuka K, Kubota R, Tokunaga M, Utsunomiya A, Umekita K, Hashikura Y, Nosaka K, Koh K-R, Nakamura H, Sagara Y, Sobata R, Satake M, Nagata K, Hasegawa Y, Sasaki D, Hasegawa H, Sato T, Yamano Y, Hiraga K, Tezuka K, Ikebe E, Matsuoka S, Okuma K, Watanabe T, Miura K, Hamaguchi I.
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 6 Pages: 1-10
- DOI
  10.1128/spectrum.02078-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15312, KAKENHI-PROJECT-21K09497, KAKENHI-PROJECT-22K08594, KAKENHI-PROJECT-22K09622, KAKENHI-PROJECT-23K06954, KAKENHI-PROJECT-23K24233, KAKENHI-PROJECT-23K24248, KAKENHI-PROJECT-23K24380
[Journal Article] Therapeutic efficacy of the resorcylic acid lactone LL‐Z1640‐2 for adult T‐cell leukaemia/lymphoma2023
- Author(s)
  Oura M、Harada T、Oda A、Teramachi J、Nakayama A、Sumitani R、Inoue Y、Maeda Y、Sogabe K、Maruhashi T、Takahashi M、Fujii S、Nakamura S、Miki H、Nakamura M、Hara T、Yamagami H、Kurahashi K、Endo I、Hasegawa H、Fujiwara H、Abe M
- Journal Title
  
  eJHaem
  
  Volume: 4 Issue: 3 Pages: 667-678
- DOI
  10.1002/jha2.758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19626, KAKENHI-PROJECT-23K21485, KAKENHI-PROJECT-23K24233, KAKENHI-PROJECT-23K27455
[Journal Article] Genome-wide CRISPR screens identify CD48 defining susceptibility to NK cytotoxicity in peripheral T-cell lymphomas2022
- Author(s)
  Chiba Masahiro、Shimono Joji、Ishio Takashi、Takei Norio、Kasahara Kohei、Ogasawara Reiki、Ara Takahide、Goto Hideki、Izumiyama Koh、Otsuguro Satoko、Perera Liyanage P.、Hasegawa Hiroo、Maeda Michiyuki、Hashino Satoshi、Maenaka Katsumi、Teshima Takanori、Waldmann Thomas A.、Yang Yibin、Nakagawa Masao
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 18 Pages: 1951-1963
- DOI
  10.1182/blood.2022015646
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02775, KAKENHI-PROJECT-23K24233
[Journal Article] RAISING is a high-performance method for identifying random transgene integration sites.2022
- Author(s)
  Wada Y, Sato T, Hasegawa H, Matsudaira T, Nao N, Coler-Reilly ALG, Tasaka T, Yamauchi S, Okagawa T, Momose H, Tanio M, Kuramitsu M, Sasaki D, Matsumoto N, Yagishita N, Yamauchi J, Araya N, et al.
- Journal Title
  
  Commun Biol
  
  Volume: 5(1) Issue: 1 Pages: 535-535
- DOI
  10.1038/s42003-022-03467-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07427, KAKENHI-PROJECT-21K08386, KAKENHI-PROJECT-22K07507, KAKENHI-PROJECT-22K19232, KAKENHI-PROJECT-22K15420, KAKENHI-PROJECT-23K23768, KAKENHI-PROJECT-23K24233, KAKENHI-PROJECT-23K24248, KAKENHI-PROJECT-22H04923
[Journal Article] Acute type adult T-cell leukemia cells proliferate in the lymph nodes rather than in peripheral blood2022
- Author(s)
  Mariko Mizuguchi, Mitsuyoshi Takatori, Shugo Sakihama, Manami Yoshita-Takahashi, Naoki Imaizumi, Yoshiaki Takahashi, Hiroo Hasegawa, Kennosuke Karube, Takuya Fukushima, Masataka Nakamura, Yuetsu Tanaka
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: - Issue: 11 Pages: 1570-1577
- DOI
  10.1038/s41417-022-00475-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08843, KAKENHI-PROJECT-23K24233
[Journal Article] Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma2022
- Author(s)
  Ishio Takashi、Kumar Sarvesh、Shimono Joji、Daenthanasanmak Anusara、Dubois Sigrid、Lin Yuquan、Bryant Bonita、Petrus Michael N.、Bachy Emmanuel、Huang Da Wei、Yang Yandan、Green Patrick L.、Hasegawa Hiroo、Maeda Michiyuki、Goto Hideki、Endo Tomoyuki、Yokota Takashi、Hatanaka Kanako C.、Hatanaka Yutaka、Tanaka Shinyaら
- Journal Title
  
  Blood
  
  Volume: 139 Issue: 10 Pages: 1541-1556
- DOI
  10.1182/blood.2021012734
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-21H02775, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-23K24233
[Journal Article] TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia2021
- Author(s)
  Ikebe Emi、Shimosaki Shunsuke、Hasegawa Hiroo、Iha Hidekatsu、Tsukamoto Yoshiyuki、Wang Yu、Sasaki Daisuke、Imaizumi Yoshitaka、Miyazaki Yasushi、Yanagihara Katsunori、Hamaguchi Isao、Morishita Kazuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 684-696
- DOI
  10.1111/cas.15204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-23K21375
[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.2021
- Author(s)
  Endo Y, Fukui S, Koga T, Sasaki D, Hasegawa H, Yanagihara K, Okayama A, Nakamura T, Kawakami A, Nakamura H. Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.
- Journal Title
  
  J Int Med Res.
  
  Volume: 49 Issue: 3 Pages: 1-10
- DOI
  10.1177/03000605211002083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08884, KAKENHI-PROJECT-19K08886, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19K17888
[Journal Article] Flow cytometry assay for the detection of single-copy DNA in human lymphocytes2020
- Author(s)
  Uno Naoki、Kaku Norihito、Morinaga Yoshitomo、Hasegawa Hiroo、Yanagihara Katsunori
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 48 Issue: 15 Pages: e86-e86
- DOI
  10.1093/nar/gkaa515
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02728, KAKENHI-PROJECT-18H02733
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma2020
- Author(s)
  Yamakawa T, Uno N, Sasaki D, Kaku N, Sakamoto K, Kosai K, Hasegawa H, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 19 Pages: 463-473
- DOI
  10.1016/j.omtm.2020.10.015
- NAID
  120006980751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-18H02733
[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020
- Author(s)
  Saito M, Hasegawa H, Yamauchi S, Nakagawa S, Sasaki D, Nao N, Tanio M, Wada Y, Matsudaira T, Momose H, Kuramitsu M, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Imaizumi Y, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 3 Pages: 300-306
- DOI
  10.1007/s12185-020-02935-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08868, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] The Effect of In Vitro Hemolysis on Measurement of Cell-Free DNA2019
- Author(s)
  Nishimura F, Uno N, Chiang PC, Kaku N, Morinaga Y, Hasegawa H, Yanagihara K
- Journal Title
  
  J Appl Lab Med
  
  Volume: 4(2) Issue: 2 Pages: 235-240
- DOI
  10.1373/jalm.2018.027953
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08986, KAKENHI-PROJECT-18H02733
[Journal Article] Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality2019
- Author(s)
  Toriyama E, Imaizumi Y, Tsuruda K, Itonaga H, Sato S, Ando K, Sawayama Y, Hasegawa H, Hata T, Niino D, Yanagihara K, Miyazaki Y
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 15 Pages: 2213-2217
- DOI
  10.2169/internalmedicine.2472-18
- NAID
  130007686846
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10050, KAKENHI-PROJECT-17K16189, KAKENHI-PROJECT-18K16121, KAKENHI-PROJECT-18H02733
[Journal Article] Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model2019
- Author(s)
  Morinaga Y, Take Y, Sasaki D, Ota K, Kaku N, Uno N, Sakamoto K, Kosai K, Miyazaki T, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K
- Journal Title
  
  PLoS One
  
  Volume: 14(9) Issue: 9 Pages: e0222589-e0222589
- DOI
  10.1371/journal.pone.0222589
- NAID
  120006988400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733
[Journal Article] Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan2018
- Author(s)
  Kuramitsu M、Okuma K、Nakashima M、Sato T、Sasaki D、Hasegawa H、Umeki K、Kubota R、Sasada K、Sobata R、Matsumoto C、Kaneko N、Tezuka K、Matsuoka S、Utsunomiya A、Koh KR、Ogata M、Ishitsuka K、Taki M、Nosaka K、Uchimaru K、Iwanaga M、Sagara Y、Yamano Y、Okayama A、Miura K et al
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 62 Issue: 10 Pages: 673-676
- DOI
  10.1111/1348-0421.12644
- NAID
  40021702629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H06277
[Journal Article] Natural course of HTLV-1 proviral DNA levels in carriers during pregnancy2018
- Author(s)
  Fuchi N, Miura K, Tsukiyama T, Sasaki D, Ishihara K, Tsuruda K, Hasegawa H, Miura S, Yanagihara K, Masuzaki H
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 217 Issue: 9 Pages: 1383-1389
- DOI
  10.1093/infdis/jiy017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-16K20198, KAKENHI-PROJECT-17K11283, KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-18H02733
[Journal Article] Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan2018
- Author(s)
  Fukumoto T, Ikebe E, Ogata M, Kohno K, Kuramitsu M, Sato Y, Fife N, Matsumoto T, Yahiro T, Ikeda M, Kusano S, Okayama A, Hori M, Hijiya N, Tsukamoto Y, Hirashita Y, Moriyama M, Ahmed K, Hasegawa H, Nishizono A, Saito M, Iha H
- Journal Title
  
  Genome Announcements
  
  Volume: 6 Issue: 25
- DOI
  10.1128/genomea.00090-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08695, KAKENHI-PROJECT-18K06992, KAKENHI-PROJECT-18H02631, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K08651, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production2018
- Author(s)
  Nomura Hajime、Umekita Kunihiko、Hashikura Yuuki、Umeki Kazumi、Yamamoto Ikuo、Aratake Yatsuki、Saito Mineki、Hasegawa Hiroo、Yanagihara Katsunori、Okayama Akihiko
- Journal Title
  
  Human Cell
  
  Volume: 32 Issue: 2 Pages: 185-192
- DOI
  10.1007/s13577-018-00231-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-18K07541
[Journal Article] Infection of defective human T-lymphotropic virus type 12017
- Author(s)
  Hashikura Yuuki、Umeki Kazumi、Umekita Kunihiko、Nomura Hajime、Yamada Akiteru、Yamamoto Ikuo、Hasegawa Hiroo、Yanagihara Katsunori、Okayama Akihiko
- Journal Title
  
  Human Cell
  
  Volume: 30 Issue: 2 Pages: 117-123
- DOI
  10.1007/s13577-016-0156-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08647
[Journal Article] Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.2017
- Author(s)
  Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, et al.
- Journal Title
  
  J Clin Microbiol.
  
  Volume: 55(9) Issue: 9 Pages: 2838-2849
- DOI
  10.1128/jcm.00659-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-17K15044, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-15K08647, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-15K14388, KAKENHI-PROJECT-16H06277
[Journal Article] Tumor necrosis factor alpha inhibitors have no effect on a human T-lymphotropic virus type-I (HTLV-I)-infected cell line from patients with HTLV-I-associated myelopathy.2017
- Author(s)
  Fukui S, Nakamura H, Takahashi Y, Iwamoto N, Hasegawa H, Yanagihara K, Nakamura T, Okayama A, Kawakami A.
- Journal Title
  
  BMC Immunol.
  
  Volume: 18 Issue: 1 Pages: 1-10
- DOI
  10.1186/s12865-017-0191-2
- NAID
  120006987561
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19605, KAKENHI-PROJECT-15K08647
[Journal Article] Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.2016
- Author(s)
  Hasegawa H, Bissonnette RP, Gillings M, Sasaki D, Taniguchi H, Kitanosono H, Tsuruda K, Kosai K, Uno N, Morinaga Y, Imaizumi Y, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 8 Pages: 1124-33
- DOI
  10.1111/cas.12971
- NAID
  120006987664
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08647
[Journal Article] Relevance of molecular tests for HTLV-1 infection as confirmatory tests after the first sero-screening2014
- Author(s)
  Ishihara K, Inokuchi N, Tsushima Y, Tsuruda K, Morinaga Y, Hasegawa H, Yanagihara K, Kamihira S
- Journal Title
  
  J Immunoassay Immunochem
  
  Volume: 35(1) Pages: 74-82
- NAID
  120006986762
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Relationships of diverse apoptotic death process patterns to mitochondrial membrane potential (Δψ(m)) evaluated by three-parameter flow cytometric analysis.2013
- Author(s)
  Suzuki Y, Hasegawa H, Tsuji T,et al
- Journal Title
  
  Cytotechnology
  
  Volume: 65(1) Issue: 1 Pages: 59-70
- DOI
  10.1007/s10616-012-9455-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] 成人T細胞白血病の細胞免疫形質診断へのアプローチ2013
- Author(s)
  鶴田一人,長谷川寛雄,佐々木大介,森沙耶香,濵﨑典子,松野貴子,本村裕美子,渕上麻衣,岡本南,津島裕子,西村典孝,木下知美,森勇人,松本成良,宇野直輝,森永芳智,上平憲,栁原克紀
- Journal Title
  
  Cytometry Research
  
  Volume: 23(2) Pages: 23-31
- NAID
  10031201111
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice2013
- Author(s)
  Ikebe E, Kawaguchi A, Tezuka K, Taguchi S, Hirose S, Matsumoto T, Mitsui T, Senba K, Nishizono A, Hori M, Hasegawa H, Yamada Y, Ueno T, Tanaka Y, Sawa H, Hall W, Minami Y, Jeang KT, Ogata M, Morishita K, Hasegawa H, Fujisawa J, Iha H
- Journal Title
  
  Blood Cancer J
  
  Volume: 3
- NAID
  120006986112
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Use of diagnostic and therapeutic biomarkers in personalized oncology based on adult T-cell leukemia/lymphoma research2013
- Author(s)
  Hasegawa H, Kamihira S
- Journal Title
  
  Personalized Medicine Universe
  
  Volume: 2 Pages: 7-11
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Transient proliferation of donor-derived ATL cell-like lymphocytes early after allogeneic stem cell transplantation in an adult T-cell leukemia/lymphoma patient2013
- Author(s)
  Taguchi M, Imaizumi Y, Taguchi J, Imanishi D, Sasaki D, Hasegawa H, Tsushima H, Hata T, Miyazaki Y
- Journal Title
  
  Blood
  
  Volume: 121(21) Pages: 4428-30
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus2012
- Author(s)
  Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, Hasegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
- Journal Title
  
  Epub ahead of print
  
  Volume: Virol J 9(1) Pages: 40-40
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia2012
- Author(s)
  Ishihara K, Sasaki D, Tsuruda K, Inokuchi N, Nagai K, Hasegawa H, Yanagihara K, Kamihira S
- Journal Title
  
  Cancer Epidemiol
  
  Volume: 36(6) Pages: 560-5
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia : continuity from carrier status to smoldering ATL2012
- Author(s)
  Kamihira S, Iwanaga M, Doi Y, Sasaki D, Mori S, Tsurda K, Nagai K, Uno N, Hasegawa H, Yanagihara K, Morinaga Y, Tsukasaki K, Taniguchi H
- Journal Title
  
  Int J Hematol
  
  Volume: 95(4) Pages: 399-408
- NAID
  10030632587
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article]2011
- Author(s)
  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE,Hayashi T, Yanagihara K, Moriwaki Y,Miyazaki Y, Kamihira S, Yamada Y,
- Journal Title
  
  Haematologica
  
  Volume: 96 Issue: 5 Pages: 712-719
- DOI
  10.3324/haematol.2010.028605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300326, KAKENHI-PROJECT-23590641
[Journal Article] Nationwide survey of adult T-cell leukemia/ lymphoma(ATL) in Japan2011
- Author(s)
  Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52(11) Pages: 1765-71
- NAID
  10030462510
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy2011
- Author(s)
  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
- Journal Title
  
  Haematologica
  
  Volume: 96(5) Pages: 712-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant overexpression of membrane-associatedmucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells2011
- Author(s)
  Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 52 Issue: 6 Pages: 1108-1117
- DOI
  10.3109/10428194.2011.559671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591065, KAKENHI-PROJECT-23590641
[Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/ lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011
- Author(s)
  Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
- Journal Title
  
  Leukemia
  
  Volume: 25(4) Pages: 575-87
- NAID
  120006984803
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells2011
- Author(s)
  Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 52(6) Pages: 1108-17
- NAID
  120006984995
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011
- Author(s)
  Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
- Journal Title
  
  Leukemia
  
  Volume: 25(4) Pages: 575-87
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011
- Author(s)
  Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
- Journal Title
  
  Leukemia
  
  Volume: 25(4) Pages: 575-87
- NAID
  120006984803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells2011
- Author(s)
  Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 52(6) Pages: 1108-17
- NAID
  120006984995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Nationwide survey of adult T-cell leukemia/lymphoma (ATL) in Japan2011
- Author(s)
  Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52(11) Pages: 1765-71
- NAID
  10030462510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] leukemia/ lymphoma as a target for epigenetic therapy2011
- Author(s)
  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
- Journal Title
  
  Haematologica
  
  Volume: 96(5) Pages: 712-9
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/ lymphoma cells2011
- Author(s)
  Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 52(6) Pages: 1108-17
- NAID
  120006984995
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway2011
- Author(s)
  Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
- Journal Title
  
  Leukemia
  
  Volume: 25 Issue: 4 Pages: 575-587
- DOI
  10.1038/leu.2010.315
- NAID
  120006984803
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591065, KAKENHI-PROJECT-23590641
[Journal Article] Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy2011
- Author(s)
  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
- Journal Title
  
  Haematologica
  
  Volume: 96(5) Pages: 712-9
- Data Source
  KAKENHI-PROJECT-23590641
[Journal Article] Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.2011
- Author(s)
  Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez V, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y.
- Journal Title
  
  Hematologica in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590580
[Journal Article] High human T cell leukemia virus type-1 (HTLV-1) provirus load in patients with HTLV-1 carriers complicated with HTLV-1-unrelated disorders.2010
- Author(s)
  Sasaki D, Doi Y, Hasegawa H, Yanagihara K, Tsukasaki K, Iwanaga M, Yamada Y, Watanabe T, Kamihira S.
- Journal Title
  
  Virology Journal 28;7:81(電子ジャーナル)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590580
[Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2010
- Author(s)
  Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
- Journal Title
  
  J Med Virol 2010
  
  Volume: 82(4) Pages: 668-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/ lymphoma in Nagasaki, Japan2010
- Author(s)
  Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
- Journal Title
  
  J Med Virol
  
  Volume: 82(4) Pages: 668-74
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Trends in HTLV-I prevalence and incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2010
- Author(s)
  Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
- Journal Title
  
  J Med Virol 2010
  
  Volume: 82(4) Pages: 668-674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer2009
- Author(s)
  Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  J Cancer Res Clin Oncol
  
  Volume: 135(3) Pages: 371-7
- NAID
  120006983957
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death.2009
- Author(s)
  Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Int J Lab Hematol 31(3)
  
  Pages: 307-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.2009
- Author(s)
  Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y
- Journal Title
  
  European Journal of Haematology 82巻
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590580
[Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene2009
- Author(s)
  Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
- Journal Title
  
  Int J Hematol
  
  Volume: 90(1) Pages: 37-43
- NAID
  10025162376
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.2009
- Author(s)
  Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.
- Journal Title
  
  Leukemia 23(11)
  
  Pages: 2090-2101
- NAID
  120006983888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations2009
- Author(s)
  Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y.
- Journal Title
  
  Eur J Haematol 82(4)
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations2009
- Author(s)
  Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y
- Journal Title
  
  Eur J Haematol
  
  Volume: 82(4) Pages: 301-7
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.2009
- Author(s)
  Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
- Journal Title
  
  Int J Hematol 90(1)
  
  Pages: 37-43
- NAID
  10025162376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death2009
- Author(s)
  Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Int J Lab Hematol
  
  Volume: 31(3) Pages: 307-14
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia.2009
- Author(s)
  Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S.
- Journal Title
  
  Intern Med 48(22):
  
  Pages: 1967-71
- NAID
  130000122220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia2009
- Author(s)
  Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S
- Journal Title
  
  Intern Med
  
  Volume: 48(22) Pages: 1967-71
- NAID
  130000122220
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer.2009
- Author(s)
  Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  J Cancer Res Clin Oncol 135(3)
  
  Pages: 371-7
- NAID
  120006983957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer.2009
- Author(s)
  Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  J Cancer Res Clin Oncol 135(3)
  
  Pages: 371-7
- NAID
  120006983957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.2009
- Author(s)
  Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.
- Journal Title
  
  Leukemia 23(11)
  
  Pages: 2090-2101
- NAID
  120006983888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications.2009
- Author(s)
  Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Tohoku J Exp Med 218(2)
  
  Pages: 99-105
- NAID
  10025106239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications2009
- Author(s)
  Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 218(2) Pages: 99-105
- NAID
  10025106239
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.2009
- Author(s)
  Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
- Journal Title
  
  Int J Hematol 90(1)
  
  Pages: 37-43
- NAID
  10025162376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells2009
- Author(s)
  Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S
- Journal Title
  
  Leukemia
  
  Volume: 23(11) Pages: 2090-101
- NAID
  120006983888
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations2009
- Author(s)
  Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y.
- Journal Title
  
  Eur J Haematol 82(4)
  
  Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death.2009
- Author(s)
  Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Int J Lab Hematol 31(3)
  
  Pages: 307-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659149
[Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications.2009
- Author(s)
  Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
- Journal Title
  
  Tohoku J Exp Med 218(2)
  
  Pages: 99-105
- NAID
  10025106239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390182
[Journal Article] Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells2008
- Author(s)
  臼井哲也、柳原克己、塚崎邦弘、村田健、長谷川寛雄, 山田恭暉, 上平憲
- Journal Title
  
  Retrovirology 5
  
  Pages: 34-34
- NAID
  120006981409
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] Foxp3 expression on normal and leukemic CD4+CD25+T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells2008
- Author(s)
  安部安樹, 鶴田一人, 尾坂明美, 柳原克己, 塚崎邦弘, 長谷川寛雄, 山田恭暉, 上平憲
- Journal Title
  
  Eur J Haematol 81(3)
  
  Pages: 209-17
- NAID
  120006982421
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12,14 prostaglandin J2 production.2007
- Author(s)
  Hasegawa Hiroo
- Journal Title
  
  Blood 110
  
  Pages: 1664-1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590494
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative(Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumnor necrosis factor related apoptosis- inducing ligand(TRAIL) through 15-deoxy-Delta 12, 14 prosaglandin J2 production.2007
- Author(s)
  Hasegawa, H., et. al.
- Journal Title
  
  Blood 110
  
  Pages: 1664-1674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590494
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12,14 prostaglandin J2 production.2007
- Author(s)
  H.Hasegawa
- Journal Title
  
  blood 100
  
  Pages: 1664-1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma2007
- Author(s)
  赤松紀彦、山田恭暉、長谷川寛雄、真壁幸樹、浅野竜太郎、熊谷泉、村田健、今泉芳孝、塚崎邦弘、鶴田一人、菅原和行、跡上直、柳原克己、上平憲
- Journal Title
  
  Cancer Lett 256(2)
  
  Pages: 196-206
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] A novel natural compound,a cycloanthranilylproline derivative(Fuligocandin B),sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand(TRAIL)through 15-deoxy-Delta 12,14 prostaglandin J2 production2007
- Author(s)
  Hasegawa Hiroo
- Journal Title
  
  Blood 110
  
  Pages: 1664-1674
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590494
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production.2007
- Author(s)
  Hasegawa H, Kamihira S., et. al.
- Journal Title
  
  Blood 110(5)
  
  Pages: 1664-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659163
[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007
- Author(s)
  長谷川寛雄, 山田恭暉, 小宮山寛機, 林正彦, 石橋正巳, 砂塚敏明, 菅原和行, 鶴田一人, 増田昌人, 高須信行, 塚崎邦弘, 朝長万左男, 上平憲
- Journal Title
  
  Blood 110(5)
  
  Pages: 1664-74
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] Dihydroflavonol BB-1,an extract of natural plant Blumea Balsamifera,abrogates TRAIL resistance in leukemia cells2006
- Author(s)
  Hasegawa Hiroo
- Journal Title
  
  Blood 107
  
  Pages: 679-688
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590494
[Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.2006
- Author(s)
  H.Hasegawa
- Journal Title
  
  blood 107(2)
  
  Pages: 679-688
- Data Source
  KAKENHI-PROJECT-18590510
[Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea Balsamifera, abrogates TRAIL resistance in leukemia cells.2006
- Author(s)
  Hasegawa, H., et. al.
- Journal Title
  
  Blood 107
  
  Pages: 679-688
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590494
[Journal Article] Dihydroflavonol BB-1, an extract of natural plant Blumea Balsamifera, abrogates TRAIL resistance in leukemia cells.2006
- Author(s)
  Hasegawa Hiroo
- Journal Title
  
  Blood 107(2)
  
  Pages: 679-688
- Data Source
  KAKENHI-PROJECT-17590494
[Patent] 非ホジキンリンパ腫発症のリスク判定補助方法2016
- Inventor(s)
  斎藤益満、伊波英克、長谷川寛雄
- Industrial Property Rights Holder
  斎藤益満、伊波英克、長谷川寛雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-150300
- Filing Date
  2016-07-29
- Acquisition Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K14388
[Presentation] 長崎県HTLV-1母子感染防止事業の結果解析2023
- Author(s)
  加勢田富士子, 小佐井康介, 柳原克紀, 吉田麻衣子, 臼井哲也, 佐々木大介, 長谷川寛雄, 三浦清徳
- Organizer
  第38回日本環境感染学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2023
- Author(s)
  松本成良, 佐々木大介, 長谷川寛雄, 小佐井康介, 加勢田富士子, 太田賢治, 柳原克紀
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] HTLV-1クロナリティのRAISING法による追跡調査2023
- Author(s)
  松本成良, 佐々木大介, 山内俊輔, 斎藤益満, 加藤丈晴, 今泉芳孝, 長谷川寛雄, 宮﨑泰司, 栁原克紀
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] 抗HTLV-1抗体検査結果と確認検査結果の比較検討2023
- Author(s)
  吉田麻衣子, 加勢田富士子, 長谷川寛雄, 太田賢治, 小佐井康介, 木村由美子, 柳原克紀, 三浦清徳
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] イムノクロマト法による新規HTLV-1抗体検査法の性能評価―多施設共同研究2022
- Author(s)
  倉光球, 石塚賢治, 久保田龍二, 佐藤知雄, 山野嘉久, 橋倉悠輝, 梅北邦彦, 野坂生郷, 長谷川寛雄, 長谷川ゆり, 三浦清徳, 宇都宮與, 高起良, 相良康子, 蕎麦田理英子, 佐竹正博, 百瀬暖佳, 手塚健太, 池辺詠美, 松岡佐保子, 大隈和, 浜口功
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] Hsp90阻害剤TAS-116 (pimitespib)のATL前臨床試験評価における有効性2022
- Author(s)
  伊波英克, 池辺詠美, 下崎俊介, 長谷川寛雄, 塚本善之, Yu Wang, 佐々木大介, 今泉芳孝, 宮﨑泰司, 柳原克紀, 森下和弘
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2022
- Author(s)
  松本成良, 長谷川寛雄, 斎藤益満,佐々木大介, 山内俊輔, 今泉芳孝, 宮﨑泰司, 栁原克紀
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] HTLV-1クロナリティ定量検査RAISING-CLOVAを用いたATL発症リスク評価法の開発2022
- Author(s)
  佐藤知雄, 斎藤益満, 和田悠作, 長谷川寛雄, 松平崇弘, 今泉芳孝, 内丸薫, 渡邊俊樹, 山野嘉久
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] 新規 HTLV-1 クロナリティ解析法（RAISING 法）による ATL の病態解析2021
- Author(s)
  松本成良、斎藤益満、佐々木大介、山内俊輔、今泉芳孝、長谷川寛雄、宮﨑泰司、栁原克紀
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 新規開発した HTLV-1 クロナリティ解析技術の ATL リスク評価法としての検討2021
- Author(s)
  斎藤益満、和田悠作、佐藤知雄、長谷川寛雄、松平崇弘、直亨則、今泉芳孝、森下和広、渡邊俊樹、山野嘉久
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 新規開発したHTLV-1クロナリティ解析技術のATLリスク評価法としての検討2021
- Author(s)
  斎藤益満、和田悠作、佐藤知雄、長谷川寛雄、松平崇弘、直亨則、今泉芳孝、森下和広、渡邊俊樹、山野嘉久
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H03594
[Presentation] 成人T細胞白血病/リンパ腫のクローン構成を評価する新規方法の開発2021
- Author(s)
  山川智弘, 佐々木大介, 太田賢治, 加勢田富士子, 長谷川寛雄, 柳原克紀
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 寛解 17 年後に再発した成人 T 細胞白血病・リンパ腫2021
- Author(s)
  西村紗央里、加藤丈晴、村山直也、佐藤信也、安東恒史、松本成良、佐々木大介、澤山靖、三好寛明、今泉芳孝、長谷川寛雄、柳原克紀、大島孝一、宮﨑泰司
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] AML with t(8;21)(q22;q22.1)における細胞抗原発現の解析2020
- Author(s)
  林田章也、長谷川寛雄、鶴田一人、森沙耶香、渕上麻衣、山内俊輔、岡本南、高田侑実、松本慧介、柳原克紀
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法(RAIS1)の開発2020
- Author(s)
  山内俊輔、斎藤益満,、長谷川寛雄、佐々木大介、渕上麻衣、森沙耶香、鶴田一人、今泉芳孝、宮崎泰司、柳原克紀
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1キャリアに対する血漿miRNAを用いたATL発症スクリーニング検査の確立2020
- Author(s)
  新野大介、佐々木大介、山内俊介、長谷川寛雄、柳原克紀、岩永正子
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1のモノクローナル組込みと挿入部位を同定する新しい検査法2019
- Author(s)
  長谷川寛雄、斎藤益満、今泉芳孝、宮﨑泰司
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] ランダムインテグレーション評価法（RAIS2）の開発と検査・解析サービスの展開2019
- Author(s)
  斎藤益満、長谷川寛雄、佐々木大介、山内俊輔、和田　悠作、松平　崇弘
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03594
[Presentation] ランダムインテグレーション評価法（RAIS2）の開発と検査・解析サービスの展開2019
- Author(s)
  斎藤益満、長谷川寛雄、佐々木大介、山内俊輔、和田悠作、松平崇弘
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1 クロナリティ解析法(RAIS1)の開発とその進捗2019
- Author(s)
  山内俊輔、長谷川寛雄、斎藤益満、佐々木大介、今泉芳孝、柳原克紀
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] Combination of lenalidomide and epigenetic drug against hematologic malignancies2019
- Author(s)
  伊波英克、池辺詠美、下﨑俊介、ファイフニコール、ファジャードリンゼイ、堀光雄、長谷川寛雄、泥谷直樹、塚本義之、守山正胤、草野秀一、斎藤益満、森下和宏
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1感染におけるモノクロナリティと挿入部位を同定する新しい検査法2019
- Author(s)
  長谷川寛雄、斎藤益満、今泉芳孝、宮﨑泰司
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1 ウイルス組み込み配列の決定およびクローン特異的定量PCR 法の開発2019
- Author(s)
  山川智弘、宇野直輝、賀来敬仁、坂本啓、森永芳智、長谷川寛雄、栁原克紀
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] キャリア妊婦におけるHTLV-1 経胎盤感染の実態解明の試み2019
- Author(s)
  手塚健太、淵直樹、大隈和、築山尚史、長谷川ゆり、長谷川寛雄、佐々木大介、三浦生子、東島愛、佐々木永太、水上拓郎、倉光球、松岡佐保子、増﨑英明、三浦清徳、浜口功
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法の開発2018
- Author(s)
  山内俊輔、斎藤益満、長谷川寛雄、佐々木大介、賀来敬仁、宇野直輝、森永芳智、今泉芳孝、宮﨑泰司、栁原克紀
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1 クロナリティ解析法の開発とその応用に向けて2018
- Author(s)
  斎藤益満、山内俊輔、佐々木大介、長谷川寛雄
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法の開発とその応用に向けて2018
- Author(s)
  斎藤益満、山内俊輔、佐々木大介、長谷川寛雄
- Organizer
  第４回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03594
[Presentation] 成人T細胞白血病・リンパ腫患者におけるHTLV-1/EBV共感染B細胞の存在意義2017
- Author(s)
  斎藤益満（さいとう　ますみち）１）、伊波英克（いは　ひでかつ）2）、長谷川寛雄（はせがわ　ひろお）3）、他35名
- Organizer
  第４回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-17H03594
[Presentation] 成人T細胞白血病・リンパ腫患者におけるHTLV-1/EBV共感染B細胞の存在意義2017
- Author(s)
  斎藤益満、伊波英克、長谷川寛雄、他35名
- Organizer
  4第回日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-15K14388
[Presentation] 2.妊婦スクリーニング検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  淵直樹，三浦清徳，佐々木大介，鶴田一人，長谷川寛雄，栁原克紀，増崎英明
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 1.臨床検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  佐々木大介，長谷川寛雄，淵直樹，三浦清徳，上野友郁，吉田彩香，松本成良，山川嘉美，賀来敬仁，小佐井康介，宇野直輝，増崎英明，栁原克紀
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 3.成人T細胞白血病・リンパ腫患者におけるHTLV-1/EBV共感染B細胞の存在意義2017
- Author(s)
  斎藤益満，伊波英克，長谷川寛雄
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 成人T細胞白血病・リンパ腫（ATL）細胞に対する新規経口HDAC阻害剤HBI-8000 (Chidamide)の効果2016
- Author(s)
  長谷川　寛雄
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  市町村自治会館(鹿児島県、鹿児島市）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] Induction of apoptosis by an HDAC inhibitor HBI8000 in ATL cells through activation of Bim and NLRP32016
- Author(s)
  長谷川　寛雄
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県、横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] Comprehensive analysis of cell lines established from carriers, smoldering, and acute ATL patients2015
- Author(s)
  長谷川寛雄
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ANAクラウンプラザホテル金沢 (石川県・金沢市)
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] EZH2 Inhibitor DZNep Induces Apoptosis In Adult T-Cell Leukemia/Lymphoma Cells By BCL2 Suppression Via Regulation Of Mir-181a2013
- Author(s)
  Sasaki Daisuke, Hasegawa Hiroo, Taniguchi Hiroaki, Yoshitaka Imaizumi, Uno Naoki, Morinaga Yoshitomo, Yasushi Miyazaki, and Yanagihara Katsunori
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  NewOrleans, LA, USA
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] EZH2 Inhibitor DZNep Induces Apoptosis In Adult T-Cell Leukemia/Lymphoma Cells By BCL2 Suppression Via Regulation Of Mir-181a2013
- Author(s)
  Daisuke Sasaki, Hiroo Hasegawa, Hiroaki Taniguchi, et al
- Organizer
  55th American Society of Hematology Annual Meeting,
- Place of Presentation
  NewOrleans, LA, USA
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] 成人T細胞白血病リンパ腫に対するHeat shock protein 90阻害薬NVP-AUY922の抗腫瘍効果2013
- Author(s)
  谷口広明、長谷川寛雄、今泉芳孝、塚崎邦弘、森直樹、宮崎泰司
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] Heat Shock Protein 90 Inhibitor NVP-AUY922 Has Potent Anti-Tumor Activity With Adult T-Cell Leukemia-Lymphoma Cells2013
- Author(s)
  Hiroaki Taniguchi, Hiroo Hasegawa, Daisuke Sasaki, Koji Ando, Yasushi Sawayama, Yoshitaka Imaizumi, Daisuke Imanishi, Jun Taguchi, Tomoko Hata, Kunihiro Tsukasaki, Katsunori Yanagihara, , Naoki Mori, and Yasushi Miyazaki
- Organizer
  55th American Society of Hematology Annual Meeting
- Place of Presentation
  NewOrleans, LA, USA
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] Heat Shock Protein 90 Inhibitor NVP-AUY922 Has Potent Anti-Tumor Activity With Adult T-Cell Leukemia-Lymphoma Cells2013
- Author(s)
  Hiroaki Taniguchi, Hiroo Hasegawa, Daisuke Sasaki, et al
- Organizer
  55th American Society of Hematology Annual Meeting,
- Place of Presentation
  NewOrleans, LA, USA
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] EZH2阻害剤DZNepはATL細胞のBCL2発現を抑制しアポトーシスを誘導する2013
- Author(s)
  佐々木大介、長谷川寛雄、今泉芳孝、宮崎泰司、上平憲
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] 成人T 細胞白血病リンパ腫に対するHeat shock protein 90 阻害薬NVP-AUY922 の抗腫瘍効果2013
- Author(s)
  谷口広明、長谷川寛雄、今泉芳孝、塚崎邦弘、森直樹、宮崎泰司
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] EZH2 阻害剤DZNep はATL 細胞のBCL2 発現を抑制しアポトーシスを誘導する2013
- Author(s)
  佐々木大介、長谷川寛雄、今泉芳孝、宮崎泰司、上平憲
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] 成人T細胞白血病リンパ腫に対するHSP 90阻害薬NVP-AUY922の抗腫瘍効果2013
- Author(s)
  谷口広明、長谷川寛雄、佐々木大介、安東恒史、澤山靖、今西大介、今泉芳孝、田口潤、波多智子、塚崎邦弘、森直樹、栁原克紀、宮崎泰司
- Organizer
  第6回HTLV-1研究会・シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] CD26 antigen act as a predictive biomarker in the evolution from early to overt smoldering ATL2012
- Author(s)
  長谷川寛雄、鶴田一人、佐々木大介、森沙耶香、土井裕子、石原香織、長井一浩、栁原克紀、塚崎邦弘、宮崎康司、上平憲
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] HTLV-1感染細胞の早期腫瘍バイオマーカーとしてのCD26抗原2012
- Author(s)
  長谷川寛雄、塚崎邦弘、宮崎康司、上平憲
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590641
[Presentation] Membrane-associated mucin MUC1 is overexpressed in adult T-cell leukemia/lymphoma cells and contributes to anti-apoptotic properties.2010
- Author(s)
  Hasegawa H, Yamada Y, Kamihira S, et al
- Organizer
  15th Congress of European Hematology Association
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-20590580
[Presentation] Membrane-associated mucin MUC1 is overexpressed in adult T-cell leukemia/lymphoma cells and contributes to anti-apoptotic properties.2010
- Author(s)
  Hasegawa H, et al.
- Organizer
  15th Congress of European Hematology Association
- Place of Presentation
  バルセロナ、スペイン
- Year and Date
  2010-06-12
- Data Source
  KAKENHI-PROJECT-20590580
[Presentation] A novel natural compound,a cycloanthranilylproline-derivative(FCB),sensitizes leukemia cells to TRAIL-induced apoptosis through 15D-PJ2 production2007
- Author(s)
  Hasegawa Hiroo
- Organizer
  36th Annual Scientific Meeting of the International Society of Experimental Hematology
- Place of Presentation
  Hamburg,Germany
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590494
[Presentation] A novel natural compound, a cycloanthranilylproline-derivative(FCB), sensitizes leukemia cells to TRAIL-induced apoptosis through 15D-PJ2 production.2007
- Author(s)
  Hasegawa, H., et. al.
- Organizer
  36th, Annual Scientific Meeting of the International Society of Experimental Hematology
- Place of Presentation
  Hamburg, Germany
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590494
[Presentation] A novel natural compound, cycloanthranilylproline derivative (FCB), sensitizes leukemia cells to TRAIL-induced apoptosis through 15-d-PG J2 production2007
- Author(s)
  長谷川寛雄
- Organizer
  Annual meeting of International society for Experimental Hematology
- Place of Presentation
  Hamburg, Germany
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] A novel natural compound, a cycloanthranilylproline-derivative (FCB), sensitizes leukemia cells to TRAIL-induced apoptosis through 15D-PJ2 production2007
- Author(s)
  Hasegawa Hiroo
- Organizer
  36^<th> Annual Scientific Meeting of The International Society of Experimental Hematology
- Place of Presentation
  Hamburg,Germany
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-17590494
[Presentation] A novel natural compound, FCB, sensitizes leukemia cells to TRAIL-induced apoptosis through 15-d-PG J2 production2007
- Author(s)
  長谷川寛雄
- Organizer
  日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] A novel natural compound,FCB,sensitizes leukemia cells to TRAIL-induced apoptsis through 15D-PGJ2 production2007
- Author(s)
  長谷川寛雄
- Organizer
  日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] A novel natural compound,a cycloanthranilylproline derivative(FCB),sensitizes leukemia cells to TRAIL-induced apoptsis through 15D-PGJ2 production2007
- Author(s)
  長谷川寛雄
- Organizer
  Intemational Society of Experimental Hematology
- Place of Presentation
  Hamburg,Germany
- Year and Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] Nutlin-3a, an MDM2 antagonist, induces p53-mediated cellular senescence and apoptosis in Adult T-cell Leukemia/Lymphoma cells.2006
- Author(s)
  長谷川寛雄
- Organizer
  Annual meeting of American society of hematology
- Place of Presentation
  Orlando, USA
- Year and Date
  2006-12-10
- Data Source
  KAKENHI-PROJECT-18590510
[Presentation] Effect of Nutlin, an p53-Mdm2, binding inhibitor, on Adult T-cell leukemia-lymphoma(ATLL) cells.2006
- Author(s)
  Hasegawa, H., et. al.
- Organizer
  Combined Annual Meeting of the 68th Japanese Society of Hematology and 48th Japanese Society of Clinical Hematology
- Place of Presentation
  Fukuoka
- Year and Date
  2006-10-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590494
[Presentation] 成人T細胞白血病・リンパ腫(ATLL)細胞に対するp53-MDM2結合阻害剤Nutlinの効果2006
- Author(s)
  長谷川寛雄
- Organizer
  第68回日本血液学会・第48回日本臨床血液学会合同総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2006-10-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590494

1. KAMIHIRA Shimeru (80108290)

# of Collaborated Projects: 7 results

# of Collaborated Products: 53 results
2. YAMADA Yasuaki (60145232)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
3. Saito Masumichi (20571045)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. 今泉芳孝 (40404305)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
5. 柳原克紀 (40315239)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
6. 佐々木大介 (90624784)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
7. HIDEKATSU Iha (50242631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 小宮山寛機 (00106676)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 林正彦 (20164965)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 日吉真照 (40448519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. IWAO Masatomo (00100892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HAYASHI Hideki (10218589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 波多智子 (10346968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 宮崎泰司 (40304943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 緒方正男 (10332892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 谷生道一 (10416662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 百瀬暖佳 (70415488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKAO Kazuhiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KUBO Yoshinao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
21. MIURA Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. NAKAGAWA Masao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. TERAMACHI Jyumpei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. NAKAMURA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. SATO Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. IWAMOTO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 宇野直輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 塚崎邦弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 八木下尚子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 坂本啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 池辺詠美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 川上純

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 田中勇悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 水口真理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 泥谷直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 守山正胤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 田中伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASEGAWA Hiroo 長谷川 寛雄

Research Projects

Research Products

Co-Researchers

Establishment of a new test method detecting HTLV-1 clonality for capture the onset of ATLPrincipal Investigator

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Establishment of individualized test method for HTLV-1 carriers based on identification and analysis of ATL-onset clonesPrincipal Investigator

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Exploration new biomarkers based on HTLV-1 carrier clone analysisPrincipal Investigator

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Possibility of a new synthetics from lamellarins: anti-leukemic and integrase-inhibitory effects against HTLV-1-related leukemia cells.Principal Investigator

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Natural compounds that enhance TRAIL-induced apoptosis : a novel molecular targeted cancer therapyPrincipal Investigator

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[Journal Article] Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations2023

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[Journal Article] Therapeutic efficacy of the resorcylic acid lactone LL‐Z1640‐2 for adult T‐cell leukaemia/lymphoma2023

HASEGAWA Hiroo 長谷川寛雄

[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.2021