Hosokawa Masato 細川雅人

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HOSOKAWA Masato 細川雅人

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Researcher Number	00435116
Other IDs	https://orcid.org/0000-0003-2377-9232
Affiliation (Current)	2025: 福岡大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 福岡大学, 薬学部, 准教授 2020: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 主席研究員 2012 – 2020: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 2016: 公益財団法人東京都医学総合研究所, 認知症高次脳機能研究分野, 主席研究員 2011: 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 2010: (財)東京都医学総合研究所, 東京都精神医学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Psychiatric science
Keywords	Principal Investigator TDP-43 / 前頭側頭葉変性症 / ゲノム編集 / 認知症 / ノックインマウス / プリオン様伝播 / モデルマウス / モデル動物 / アルツハイマー病 / タウ … More / プログラニュリン / リードスルー活性 / 未成熟終止コドン / 動物モデル / ピック病 / 大脳皮質基底核変性症 / CRISPR/Cas9 / Tau / 神経変性疾患 / 病態モデル / CRISPR-Cas9 / C9orf72 / トランスジェニックマウス / グラニュリン / タンパク質異常凝集 / 疾患モデルマウス / tau / 筋萎縮性側索硬化症 / 脳脊髄液 / ELISA … More Except Principal Investigator TDP-43 / タウ / 認知症 / バイオマーカー / 脳梗塞 / プリオン / 筋萎縮性側索硬化症 / アグリソーム / プロフィリン１ / prion / seeding / LC3 / aggresome / mutation / ALS / Profilin1 / 異常蛋白蓄積 / 伝播 / 異常蓄積蛋白 / 病理 / 前頭側頭葉変性症 / FUS / アルツハイマー病 / グラニュリン / プロテイノパチー / 老年精神医学 Less

The exploration of new therapeutic agents for frontotemporal lobar degeneration focusing on read-through activity.Principal Investigator
- Principal Investigator
  
  細川雅人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fukuoka University
新規前頭側頭葉変性症モデルの作製とプリオン様伝播機構の解明Principal Investigator
- Principal Investigator
  
  細川雅人
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fukuoka University
Utilities of plasma protein as a biomarker for the progression of cerebral infarction
- Principal Investigator
  
  Irie Keiichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Fukuoka University
Elucidation of new pathogenic mechanisms of dementia and development of new therapeutic agentsPrincipal Investigator
- Principal Investigator
  
  Hosokawa Masato
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fukuoka University
  Tokyo Metropolitan Institute of Medical Science
Development of novel frontotemporal lobar degeneration model mice using genome editing.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Masato
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations
- Principal Investigator
  
  TANAKA Yoshinori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Creation of novel model mice for dementia research and development of new medicines for dementia treatment.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Masato
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The development of clinical diagnosis for frontotemporal lobar degenerationPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Masato
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research
Experimental research on the pathogenesis and pathophysiology of diseases that cause dementia
- Principal Investigator
  
  AKIYAMA Haruhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research

[Book] Progranulin and Central Nervous System Disorders2019
- Author(s)
  Hara, Hosokawa, Nakamura, Shimohata, Nishihara
- Total Pages
  183
- Publisher
  Springer Nature
- ISBN
  9789811361852
- Data Source
  KAKENHI-PROJECT-18K07618
[Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022
- Author(s)
  Hosokawa M, Masuda-Suzukake M, Shitara H, Shimozawa A, Suzuki G, Kondo H, Nonaka T, Campbell W, Arai T, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 145 Issue: 1 Pages: 349-361
- DOI
  10.1093/brain/awab289
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07618, KAKENHI-PROJECT-19K07860, KAKENHI-PROJECT-21K07288, KAKENHI-PROJECT-22K07362
[Journal Article] Therapeutic effect of anti-HMGB1 antibody in a mouse model of 4-h middle cerebral artery occlusion: comparison with tissue plasminogen activator2022
- Author(s)
  Nakano Takafumi、Tagashira Yui、Egashira Saki、Morimoto Mayuka、Irie Keiichi、Hosokawa Masato、Hayashi Toshinobu、Egawa Takashi、Hayakawa Kazuhide、Mishima Kenichi
- Journal Title
  
  NeuroReport
  
  Volume: 33 (7) Issue: 7 Pages: 297-303
- DOI
  10.1097/wnr.0000000000001780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07215, KAKENHI-PROJECT-19K16432
[Journal Article] プログラニュリン2019
- Author(s)
  細川雅人
- Journal Title
  
  非定型パーキンソニズム-基礎と臨床-
  
  Volume: 0 Pages: 209-215
- Data Source
  KAKENHI-PROJECT-18K07618
[Journal Article] Prion-like Propagation Model of Tau2019
- Author(s)
  細川雅人、長谷川成人
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 7 Pages: 1021-1025
- DOI
  10.1248/yakushi.18-00165-6
- NAID
  130007670809
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-07-01
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-18K07618
[Journal Article] タウのプリオン様伝播動物モデル2019
- Author(s)
  細川雅人
- Journal Title
  
  Dementia Japan
  
  Volume: 33 Pages: 306-317
- Data Source
  KAKENHI-PROJECT-18K07618
[Journal Article] Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice2018
- Author(s)
  Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M
- Journal Title
  
  Exp. Anim.
  
  Volume: 67 Issue: 1 Pages: 63-70
- DOI
  10.1538/expanim.17-0060
- NAID
  130006339997
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Clinical features of behavioral variant of frontotemporal dementia useful for predicting underlying pathological subtypes of frontotemporal lobar degeneration2018
- Author(s)
  Kobayashi Z, Arai T, Kawakami I, Yokota O, Hosokawa M, Oshima K, Niizato K, Shiraishi A, Akiyama H, Mizusawa H
- Journal Title
  
  Psychogeriatrics
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850
[Journal Article] Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation2017
- Author(s)
  Hosokawa M, Arai T. Kondo H. Serrano GE. Beach TG. Robinson AC. Mann DM. Akiyama H. Haesgawa M
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1513-1513
- DOI
  10.1038/s41598-017-01587-6
- NAID
  120007129118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.2017
- Author(s)
  Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 969-988
- DOI
  10.1093/hmg/ddx011
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-15K18370, KAKENHI-PROJECT-16K21650, KAKENHI-PROJECT-15K09850, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356
[Journal Article] iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons2017
- Author(s)
  Imamura K, Izumi Y, 他24名, Hosokawa M, Akiyama H, Ayaki T, Ito H, Takahashi R, Yamanaka S, Inoue H
- Journal Title
  
  Science Translational Medicine
  
  Volume: 9 Issue: 391 Pages: 391-391
- DOI
  10.1126/scitranslmed.aaf3962
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-16K09681, KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-17KT0108, KAKENHI-PUBLICLY-17H05670, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H05019, KAKENHI-PROJECT-17H06622, KAKENHI-PROJECT-15K06921, KAKENHI-PLANNED-26114009
[Journal Article] Chorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration.2016
- Author(s)
  Kawakami I, Kobayashi Z, Arai T, Yokota O, Nonaka T, Aoki N, Niizato K, Oshima K, Higashi S, Katsuse O, Hosokawa M, Hasegawa M, Akiyama H.
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 4 Issue: 1 Pages: 36-36
- DOI
  10.1186/s40478-016-0304-9
- NAID
  120007135517
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09822, KAKENHI-PROJECT-15K09850, KAKENHI-PUBLICLY-26111730, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-15K19757, KAKENHI-PROJECT-26461752
[Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method2016
- Author(s)
  Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S
- Journal Title
  
  American Journal of Pathology
  
  Volume: 186 Issue: 2 Pages: 398-409
- DOI
  10.1016/j.ajpath.2015.10.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09850, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26117004, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-25290024, KAKENHI-PROJECT-16K07060, KAKENHI-PROJECT-16H06277
[Journal Article] Progranulin reduction is associated with tau phosphorylation in P301L tau transgenic mice2015
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Kondo H, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Journal Title
  
  J Neuropahol Exp Neurol
  
  Volume: 74 Issue: 2 Pages: 158-165
- DOI
  10.1097/nen.0000000000000158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Moderate maternal food restriction in mice impairs physical growth, behaviors, and neurodevelopment of offspring2015
- Author(s)
  Akitake Y, Katsuragi S, Hosokawa M, Mishima K, Ikeda T, Miyazato M, Hosoda H
- Journal Title
  
  Neutrition Research
  
  Volume: 35 Issue: 1 Pages: 76-87
- DOI
  10.1016/j.nutres.2014.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-24592495, KAKENHI-PROJECT-24791128
[Journal Article] Tau accumulation in the nucleus accumbens in tangle-predominant dementia2014
- Author(s)
  Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Katsuse O, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: Commun 2 Issue: 1 Pages: 40-40
- DOI
  10.1186/2051-5960-2-40
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014
- Author(s)
  Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 23 Issue: 16 Pages: 4345-56
- DOI
  10.1093/hmg/ddu152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-24700370, KAKENHI-PUBLICLY-25123726, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] Differential diagnosis of amyotrophic lateral sclerosis from Guillain-Barré syndrome by quantitative determination of TDP-43 in cerebrospinal fluid.2014
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Masuda-Suzukake M, Tamaoka A, Hasegawa M, Akiyama H.
- Journal Title
  
  Int. J. Neurosci.
  
  Volume: 124 Issue: 5 Pages: 344-349
- DOI
  10.3109/00207454.2013.848440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] Pathological alpha-synuclein propagates through neural networks2014
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M
- Journal Title
  
  Acta Neuropathol Commun
  
  Volume: 2 Issue: 1 Pages: 88-88
- DOI
  10.1186/preaccept-1296467154135944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005
[Journal Article] An autopsied case of corticobasal degeneration showing severe cerebral atrophy over a protracted disease course of 16 years2014
- Author(s)
  Kondo D, Hino H, Shibuya K, Fujisawa K, Kosaka K, Hirayasu Y, Yamamoto R, Kasanuki K, Minegishi M, Sato K, Hosokawa M, Arai T, Arai H, Iseki E
- Journal Title
  
  Neuropathology
  
  Volume: Epub ahead of print Issue: 3 Pages: 280-288
- DOI
  10.1111/neup.12188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-15K09850
[Journal Article] Atypical FTLD-FUS associated with ALS-TDP : a case report2013
- Author(s)
  Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H
- Journal Title
  
  Neuropathology
  
  Volume: 33 Issue: 1 Pages: 83-86
- DOI
  10.1111/j.1440-1789.2012.01325.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738
[Journal Article] Microsomal prostaglandin E synthase-1 is induced in Alzheimer's disease and its deletion mitigates Alzheimer's disease-like pathology in a mouse model2013
- Author(s)
  Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 91(7) Issue: 7 Pages: 909-919
- DOI
  10.1002/jnr.23217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390036, KAKENHI-PROJECT-23790099, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24590582, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23116515
[Journal Article] Prion-like spreading of pathological alpha-synuclein in brain.2013
- Author(s)
  Masuda-Suzukake M, Nonaka T, Hosokawa M., Oikawa T, Arai T, Akiyama H, Mann D, Hasegawa M
- Journal Title
  
  Brain
  
  Volume: 136 Issue: 4 Pages: 1128-38
- DOI
  10.1093/brain/awt037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PUBLICLY-24111556, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738, KAKENHI-PUBLICLY-23110526
[Journal Article] Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases.2013
- Author(s)
  Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.
- Journal Title
  
  Neurol. Sci.
  
  Volume: 335 Issue: 1-2 Pages: 89-95
- DOI
  10.1016/j.jns.2013.08.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591714, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-25110738
[Journal Article] Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice.2012
- Author(s)
  Hosokawa M
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 12 Pages: e52389-e52389
- DOI
  10.1371/journal.pone.0052389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in AβPP and AβPP/tau transgenic mice2012
- Author(s)
  Akiyama H, Hosokawa M, Kametani F, Kondo H, Chiba M, Fukushima M, Tabira T
- Journal Title
  
  Neuropathology
  
  Volume: (in press) Issue: 4 Pages: 390-397
- DOI
  10.1111/j.1440-1789.2011.01274.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-22791157, KAKENHI-PROJECT-24591738
[Journal Article] Molecular analysis and biochemical classification of TDP-43 proteinopathy2012
- Author(s)
  Tsuji H
- Journal Title
  
  Brain
  
  Volume: 135(11) Issue: 11 Pages: 3380-91
- DOI
  10.1093/brain/aws230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-22590968, KAKENHI-PROJECT-23240050, KAKENHI-PROJECT-23500435, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-23700433, KAKENHI-PROJECT-24300133, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591249, KAKENHI-PROJECT-24591738, KAKENHI-PUBLICLY-23110526
[Journal Article] Localization of fused in sarcoma(FUS) protein to the post synaptic density in the brain2012
- Author(s)
  Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H
- Journal Title
  
  Acta Neuropathol
  
  Volume: (in press) Issue: 3 Pages: 383-94
- DOI
  10.1007/s00401-012-0984-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591536, KAKENHI-PROJECT-22591292, KAKENHI-PROJECT-23791008, KAKENHI-PROJECT-23791346, KAKENHI-PROJECT-24500429
[Journal Article] ALS-D-FTLD-MND-FTLD-U2011
- Author(s)
  新井哲明、小林禅、細川雅人、長谷川成人、秋山治彦
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 995-998
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] Long-term oral intake of aluminium or zinc does not accelerate Alzheimer pathology in APP and APP/tau transgenic mice2011
- Author(s)
  Haruhiko Akiyama, Masato Hosokawa, Fuyuki Kamentani, Hiromi Kondo, Momoko Chiba, Masako Fukushima, Takeshi Tabira
- Journal Title
  
  Neuropathology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] TDP-43分子による新たな認知症群2011
- Author(s)
  新井哲明、細川雅人、長谷川成人、秋山治彦、朝田隆
- Journal Title
  
  精神神経学雑誌
  
  Volume: 第113巻第6号 Pages: 574-583
- NAID
  10029576302
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] 前頭側頭葉変性症の分子病理2011
- Author(s)
  新井哲明、山下万貴子、細川雅人, 他5名
- Journal Title
  
  Dementia Japan
  
  Volume: 25 Pages: 120-127
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] Phosphorylated and cleaved TDP-43 in ALS/FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy2010
- Author(s)
  Arai T, Hasegawa M, Nonoka T, et al
- Journal Title
  
  Neuropathology
  
  Volume: 30 Issue: 2 Pages: 170-181
- DOI
  10.1111/j.1440-1789.2009.01089.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500339, KAKENHI-PROJECT-21591536
[Journal Article] 認知症臨床に役立つ生物学的精神医学第3回前頭側頭葉変性症と遺伝要因2010
- Author(s)
  細川雅人、新井哲明、秋山治彦、朝田隆
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 第21巻第12号 Pages: 1387-1398
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] 前頭側頭葉変性症と遺伝要因2010
- Author(s)
  細川雅人、新井哲明、秋山治彦、朝田隆
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 21 Pages: 1387-1398
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] 認知症の発症にかかわる遺伝子TDP-432010
- Author(s)
  細川雅人、新井哲明、秋山治彦
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 第21巻第5号 Pages: 561-571
- Data Source
  KAKENHI-PROJECT-22791157
[Journal Article] 認知症の発症に関わる遺伝子 TDP-432010
- Author(s)
  細川雅人、新井哲明、秋山治彦
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 21 Pages: 561-571
- Data Source
  KAKENHI-PROJECT-22791157
[Patent] METHOD OF PRODUCING A NOVEL DISEASE MODEL ANIMAL FOR TAUOPATHIES2020
- Inventor(s)
  細川雅人、設樂浩志、長谷川成人
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18K07618
[Patent] 新規タウオパチーモデル動物の作製方法2019
- Inventor(s)
  細川雅人、設樂浩志、長谷川成人
- Industrial Property Rights Holder
  公益財団法人東京都医学総合研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-037753
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] 脳梗塞モデルマウスにおけるSerum Amyloid A(SAA)の動態2023
- Author(s)
  江頭早紀、真崎有裕子、向井梨恵、中野貴文、細川雅人、亀谷富由樹、入江圭一、佐藤朝光、山下郁太、佐野和憲、三島健一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07215
[Presentation] 中大脳動脈閉塞マウスを用いた脳梗塞遅延期におけるanti-HMGB1抗体の治療効果2022
- Author(s)
  田頭祐依、江頭早紀、森本麻友香、江口幸臣、中野貴文、入江圭一、細川雅人、山下郁太、佐野和憲、三島健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07215
[Presentation] 脳梗塞モデルマウスにおける血中タンパク質の動態2022
- Author(s)
  江頭早紀、中野貴文、田頭祐依、仲村佳彦、江口幸臣、亀谷富由樹、細川雅人、佐藤朝光、入江圭一、山下郁太、佐野和憲、三島健一
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07215
[Presentation] Dynamics of plasma Serine protease inhibitor A3N (Serpina3n) level following focal cerebral ischemia in mice2022
- Author(s)
  Saki Egashira, Hiroshi Kashiwagi, Minami Mori, Takafumi Nakano, Keichi Irie, Masato Hosokawa, Fuyuki Kametani, Yoshiriko Nakamura, Shunya Otsubo, Tomomitsu Satho, Yuta Yamashita, Kazunori Sano, Kenichi Mishima
- Organizer
  NEURO 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07215
[Presentation] Development of tau propagation mice model2021
- Author(s)
  Hosokawa M
- Organizer
  Asian Pacific Prion Symposium 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウのプリオン様伝播の病態－モデルマウスの解析から2020
- Author(s)
  細川雅人、鈴掛雅美、長谷川成人
- Organizer
  第39回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] Animal model of tauopathy and tau propagation2020
- Author(s)
  細川雅人、長谷川成人
- Organizer
  第61回日本神経病理学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウオパチーとタウ伝播のマウスモデル2020
- Author(s)
  細川雅人、鈴掛雅美、長谷川成人
- Organizer
  第92回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウのプリオン様伝播モデルマウス2019
- Author(s)
  細川雅人、下沢明希、鈴掛雅美、設楽浩志、新井哲明、長谷川成人
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] ALSモデルマウスの作製と治療薬開発2019
- Author(s)
  細川雅人
- Organizer
  第3回せりか基金
- Invited
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウ伝播モデルマウスの作製2019
- Author(s)
  細川雅人、下沢明希、鈴掛雅美、長谷川成人
- Organizer
  第92回日本薬理学会
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease mouse model2019
- Author(s)
  Hosokawa M, Tanaka Y, Arai T, Kondo H, Akiyama H, Hasegawa M
- Organizer
  ADPD2019 The 14th International Conference on Alzheimer's & Parkinson's Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] Development of tau propagation mice model2019
- Author(s)
  Hosokawa M, Hasegawa M
- Organizer
  6th Congress of Asian College of Neuropsychopharmacology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウのプリオン様伝播モデルマウス2019
- Author(s)
  細川雅人、下沢明希、鈴掛雅美、設楽浩志、新井哲明、長谷川成人
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウの伝播モデル動物2018
- Author(s)
  細川雅人、長谷川成人
- Organizer
  第37回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07618
[Presentation] タウのプリオン様伝播モデル2018
- Author(s)
  細川雅人
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] TDP-43 proteinopathyモデルマウスの作製2017
- Author(s)
  細川雅人、新井哲明、野中隆、亀谷富由樹、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  2017年度　生命科学系学会合同年会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパクの重複蓄積2017
- Author(s)
  細川雅人、長谷川成人、小久保康昌
- Organizer
  日本医療研究開発機構研究費（難治性疾患実用化研究事業）紀伊ALS/PDC診療ガイドラインの作製と臨床研究の推進班　平成28年度班会議
- Place of Presentation
  愛知県産業労働センター（愛知県名古屋市）
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] タウのプリオン様伝播モデルマウスの作製2017
- Author(s)
  細川雅人、下沢明希、鈴掛雅美、新井哲明、設楽浩志、長谷川成人
- Organizer
  第1回伝播性タンパク研究会
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] プログラニュリンのハプロ不全はADモデルマウスにおけるAβの蓄積を減少する2017
- Author(s)
  細川雅人、田中良法、新井哲明、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] TDP-43 proteinopathyモデルマウスの作製2017
- Author(s)
  細川雅人、新井哲明、野中隆、亀谷富由樹、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  第137回　日本薬学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] TDP-43 proteinopathyモデルマウスの作製2017
- Author(s)
  細川雅人、新井哲明、野中隆、亀谷富由樹、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  第47回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] Phosphorylated tau and α-synuclein accumulation in familial granulin mutation cases2016
- Author(s)
  Hosokawa M, Arai T, Kondo H, Serrano GE, Beach TG, Hasegawa M, Akiyama H
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント（カナダ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパクの重複蓄積2016
- Author(s)
  細川雅人
- Organizer
  第1回　プログラニュリン研究会
- Place of Presentation
  岐阜大学サテライトキャンパス（岐阜県岐阜市）
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] Multiple accumulation of neurodegenerative disease-related proteins in familial granulin mutation brains2016
- Author(s)
  Hosokawa M, Arai T, Kondo H, Serrano GE, Beach TG, Hasegawa M, Akiyama H
- Organizer
  10th International Conference on Frontotemporal Dementias
- Place of Presentation
  ミュンヘン（ドイツ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] Progranulin overexpression decrease levels of the matured form of cathepsin D due to enhancement of lysosomal acidificaition.2016
- Author(s)
  Tanaka Y, Suzuki G, Hosokawa M, Kametani F, Hasegawa M, Nishihara M.
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-15K18370
[Presentation] TDP-43 proteinopathyモデルマウスの作製2016
- Author(s)
  細川雅人、新井哲明、野中隆、亀谷富由樹、近藤ひろみ、秋山治彦、長谷川成人
- Organizer
  第35回　日本認知症学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] Multiple accumulation of neurodegenerative disease-related proteins in familial granulin mutation brains2016
- Author(s)
  Hosokawa M, Arai T, Kondo H, Serrano GE, Beach TG, Hasegawa M, Akiyama H
- Organizer
  30th CINP World Congress of Neuropsychopharmacology
- Place of Presentation
  ソウル（韓国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパクの重複蓄積2016
- Author(s)
  細川雅人、新井哲明、近藤ひろみ、長谷川成人、秋山治彦
- Organizer
  第46回　日本神経精神薬理学会
- Place of Presentation
  ソウル（韓国）
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] The abundance of nonphosphorylated tau among heterogeneously phosphorylated tau species in vivo in mice and human brains2015
- Author(s)
  木村妙子、初田裕幸、鈴掛－増田雅美、細川雅人、石黒幸一、秋山治彦、村山繁雄、長谷川成人、久永眞市
- Organizer
  第58回　日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ（埼玉県・さいたま市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] グラニュリン変異脳における神経変性疾患関連タンパク質の重複蓄積2015
- Author(s)
  細川雅人，新井哲明，近藤ひろみ，長谷川成人，秋山治彦
- Organizer
  第34回日本認知症学会
- Place of Presentation
  リンクステーション青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] プログラニュリン変異脳における神経変性疾患関連タンパク質の重複蓄積2015
- Author(s)
  細川雅人、新井哲明、近藤ひろみ、長谷川成人、秋山治彦
- Organizer
  第34回　日本認知症学会
- Place of Presentation
  リンクステーションホール青森（青森県・青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] グラニュリン変異例における神経変性疾患関連タンパクの重複蓄積2015
- Author(s)
  細川雅人、新井哲明、近藤ひろみ、長谷川成人、秋山治彦
- Organizer
  異常タンパク伝播仮説に基づく神経疾患の画期的治療法の開発平成27年度　成果報告会
- Place of Presentation
  東京都医学総合研究所（東京都・世田谷区）
- Year and Date
  2015-12-17
- Data Source
  KAKENHI-PROJECT-15K09850
[Presentation] タウトランスジェニックマウスにおいてプログラニュリンの減少はタウのリン酸化に影響を与える2014
- Author(s)
  細川雅人、新井哲明、増田－鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第61回　日本実験動物学会
- Place of Presentation
  札幌　札幌コンベンションセンター
- Year and Date
  2014-05-15
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] プログラニュリンの減少はタウのリン酸化を亢進させる2014
- Author(s)
  細川雅人、新井哲明、増田－鈴掛雅美、近藤ひろみ、松脇貴志、西原真杉、長谷川成人、秋山治彦
- Organizer
  第33回　日本認知症学会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 妊婦の摂取栄養が子供の脳と精神に及ぼす影響2014
- Author(s)
  秋武義治、桂木真司、細川雅人、池田智明、細田洋司
- Organizer
  第3回　日本DOHaD研究会学術集会
- Place of Presentation
  東京　国立成育医療研究センター
- Year and Date
  2014-07-25
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Analysis of Tau phosphorylation in Tauopathy using Phos-tag SDS-PAGE2014
- Author(s)
  木村妙子、細川智永、堤弘次、初田裕幸、鈴掛－増田雅美、細川雅人、福島寛美、石黒幸一、秋山治彦、村山繁雄、長谷川成人、久永眞市
- Organizer
  第55回　日本神経病理学会
- Place of Presentation
  東京　学術総合センター
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2013
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Nonaka T, Yamashita M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] アルツハイマー病脳における神経炎症2013
- Author(s)
  秋山治彦, 下村洋子, 近藤ひろみ, 羽賀千恵, 細川雅人
- Organizer
  第32回　日本認知症学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 蓄積αシヌクレインはマウス脳内でプリオン様の伝播能を示す2013
- Author(s)
  鈴掛雅美、野中隆、細川雅人、笈川貴行、新井哲明、David M. A. Mann、秋山治彦、長谷川成人
- Organizer
  第86回　日本生化学会
- Place of Presentation
  横浜　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] タウオパチー病理変化の基礎2013
- Author(s)
  新井哲明, 河上緒, 小林禅, 野中隆, 長谷川成人, 細川雅人, 秋山治彦, 池田研二, 朝田隆
- Organizer
  第32回　日本認知症学会
- Place of Presentation
  松本　キッセイ文化ホール
- Invited
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] レビー小体型認知症患者脳不溶性画分の脳内接種は野生型マウス脳にレビー小体様病理を形成させる2013
- Author(s)
  鈴掛雅美、野中隆、細川雅人、笈川貴行、新井哲明、秋山治彦、マン　デイビッド、長谷川成人
- Organizer
  第54回　日本神経病理学会
- Place of Presentation
  東京　タワーホール船堀
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] 全経過16年で高度な大脳萎縮を呈した皮質基底核変性症の1剖検例2013
- Author(s)
  近藤大三, 井関栄三, 笠貫浩史, 峯岸道子, 新井平伊, 細川雅人, 新井哲明, 日野博昭, 藤澤浩四郎, 小阪憲司
- Organizer
  第32回　日本認知症学会
- Place of Presentation
  松本　キッセイ文化ホール
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Methylene blue reduced tau phosphorylation and aggregation in P301L transgenic mice2012
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Hasegawa M, Akiyama H
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver, BC, Canada
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Changes in progranulin expression following focal cerebral ischemia associated with microglial activation in mice2012
- Author(s)
  Furukawa A, Irie K, Akitake Y, Hosokawa M, 他12名
- Organizer
  第89回日本生理学会
- Place of Presentation
  松本
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討2012
- Author(s)
  細川雅人、新井哲明、野中隆, 他5名
- Organizer
  第132回日本薬学会
- Place of Presentation
  札幌(北海道大学)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders2011
- Author(s)
  Masato Hosokawa, Tetsuaki Arai, Makiko Yamashita, Hiroshi Tsuji, Takashi Nonaka, Masato Hasegawa, Haruhiko Akiyama
- Organizer
  International Conference on Alzheimer's Disease 2011
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] メチレンブルーによるリン酸化タウ蓄積抑制効果の検討2011
- Author(s)
  細川雅人、新井哲明、野中隆, 他4名
- Organizer
  第30回日本認知症学会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] Histopathological analysis of progranulin knockout mice2011
- Author(s)
  Arai T, Mizukami K, Nishihara M, Hosokawa M, 他6名
- Organizer
  ICAD 2011
- Place of Presentation
  Paris (France)
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative disorders2011
- Author(s)
  Hosokawa M, Arai T, Yamashita M, Tsuji H, Nonaka T, Hasegawa M, Akiyama H
- Organizer
  International Conference on Alzheimer's Disease 2011
- Place of Presentation
  Paris France
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Quantitative determination of TDP-43 in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and other neurodegenerative2011
- Author(s)
  Hosokawa M, Arai T, Yamashita M, 他4名
- Organizer
  ICAD 2011
- Place of Presentation
  Paris (France)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, 他6名
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington D.C.(USA)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22791157
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington D. C., USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice2011
- Author(s)
  Hosokawa M, Arai T, Nonaka T, Yamashita M, Suzukake M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington D.C.USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Screening for FUS proteinopathy in the institutional brain collection2010
- Author(s)
  Akiyama H, Kobayashi Z, Arai T, Hosokawa M, Tsuchiya K, Yokota O, Shimomura Y, Kondo H, Haga C, Hasegawa M
- Organizer
  The 7th International Conference on Frontotemporal Dementias
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21591536
[Presentation] Three Autopsy Cases of FTD-MND with Progressive Aphasia
- Author(s)
  Kawakami I, Higashi S, Aoki N, Niizato K, Oshima K, Katsuse O, Togo T, Kobayashi Z, Hosokawa M, Tsuji H, Tamaoka A, Hasegawa M, Arai T, Tsuchiya K, Hirayasu Y, Akiyama H
- Organizer
  8th International Conference on FTD
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Does frontotemporal dementia associated with chorea suggest the diagnosis of frontotemporal lobar degeneration with fused in sarcoma positive inclusions of the basophilic inclusion body disease subtype?
- Author(s)
  Kawakami I, Kobayashi Z, Arai T, Yokota O, Niizato K, Oshima K, Hosokawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Vancouver, B.C. Canada
- Year and Date
  2014-10-23 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-24591738
[Presentation] Localization of Fused in Sarcoma (FUS) Protein to the Post Synaptic Density in the Brain
- Author(s)
  Akiyama H, Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Togo T, Hirayasu Y
- Organizer
  8th International Conference on FTD
- Place of Presentation
  Manchester, UK
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] アルツハイマー病脳における神経炎症
- Author(s)
  秋山治彦，下村洋子，近藤ひろみ，羽賀千恵，細川雅人
- Organizer
  日本認知症学会
- Place of Presentation
  松本市
- Invited
- Data Source
  KAKENHI-PROJECT-24500429
[Presentation] Progranulin reduction affects tau phosphorylation in P301L tau transgenic mice
- Author(s)
  Hosokawa M, Arai T, Masuda-Suzukake M, Nonaka T, Yamashita M, Matsuwaki T, Nishihara M, Hasegawa M, Akiyama H
- Organizer
  The 11th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Firenze, Italy.
- Data Source
  KAKENHI-PROJECT-24500429

1. AKIYAMA Haruhiko (20231839)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. HASEGAWA Masato (10251232)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. ARAI Tetsuaki (90291145)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
4. Irie Keiichi (50509669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. TANAKA Yoshinori (00747933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. NONAKA Takashi (30356258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAMETANI Fuyuki (70186013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SUZUKI Genjiro (60466034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 三島健一 (00320309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 仲村佳彦 (20632201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 中野貴文 (40804539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 佐野和憲 (50534343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 佐藤朝光 (90369025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 山下郁太 (90823964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 盛田友里絵 (41001928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUWAKI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. HIGASHI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 西原真杉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中谷良人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 原俊太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 平井宏和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 山下俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 長谷川寿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 岡戸晴生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosokawa Masato 細川 雅人

HOSOKAWA Masato 細川 雅人

Research Projects

Research Products

Co-Researchers

The exploration of new therapeutic agents for frontotemporal lobar degeneration focusing on read-through activity.Principal Investigator

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新規前頭側頭葉変性症モデルの作製とプリオン様伝播機構の解明Principal Investigator

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Utilities of plasma protein as a biomarker for the progression of cerebral infarction

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Elucidation of new pathogenic mechanisms of dementia and development of new therapeutic agentsPrincipal Investigator

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Development of novel frontotemporal lobar degeneration model mice using genome editing.Principal Investigator

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The mechanism of cytotoxicity from ALS-linked Profilin 1 mutations

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Creation of novel model mice for dementia research and development of new medicines for dementia treatment.Principal Investigator

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Pathological study of abnormal protein accumulation and its propagation in the brain of patients with dementia

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The development of clinical diagnosis for frontotemporal lobar degenerationPrincipal Investigator

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Experimental research on the pathogenesis and pathophysiology of diseases that cause dementia

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[Book] Progranulin and Central Nervous System Disorders2019

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[Journal Article] Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms2022

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[Journal Article] Therapeutic effect of anti-HMGB1 antibody in a mouse model of 4-h middle cerebral artery occlusion: comparison with tissue plasminogen activator2022

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Hosokawa Masato 細川雅人

HOSOKAWA Masato 細川雅人