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Takahashi Tetsuya  高橋 哲也

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… Alternative Names

高橋 哲也  タカハシ テツヤ

TAKAHASHI Tetsuya  高橋 哲也

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Researcher Number 00435942
Other IDs
Affiliation (based on the past Project Information) *help 2020 – 2023: 広島国際大学, 総合リハビリテーション学部, 教授
2019: 広島大学, 病院(医), 講師
2016 – 2017: 広島大学, 病院(医), 講師
2015: 広島大学, 大学病院, 講師
2014: 広島大学, 病院(医), 講師 … More
2013: 広島大学, 大学病院, 講師
2009 – 2011: Hiroshima University, 病院, 講師
2008 – 2009: 広島大学, 大学院・医歯薬学総合研究科, 助教
2006 – 2007: Hiroshima University, 病院, 助教
2006: 広島大学, 病院・助手
2006: Hiroshima University, Graduate School of Biomedical Sciences, Assistant professor Less
Review Section/Research Field
Principal Investigator
Neurology / Basic Section 52020:Neurology-related
Except Principal Investigator
Neurology / Basic Section 59010:Rehabilitation science-related / Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords
Principal Investigator
蛋白質 / 神経科学 / 脳神経疾患 / 細胞モデル / ナノ粒子 / リン脂質 / タウ蛋白 / エンドサイトーシス / アミロイドβペプチド / 低分子量GTPase … More / プロテオグリカン / 脂質ラフト / マクロピノサイトーシス / アミロイドβ / アミロイドベータ / アルツハイマー病 / protein / gene / neuroscience / neurological disorder / 遺伝子 / たんぱく質 … More
Except Principal Investigator
認知症 / 動物モデル / 虚血性脳損傷 / WWI-FPS/15 / アルツハイマー型認知症 / レビー小体型認知症 / パーキンソン病 / 軽度認知障害 / 思考緩慢 / ワゴンホイール効果 / アミロイドβ / APOE / アルツハイマー病 / 脳梗塞 / バイオマーカー / 脳卒中 / animal model / neuronal stem cell / ischemic brain injury / 神経幹細胞 / 筋委縮性側索硬化症 / NFkB / TRAF6 / NF-kB / autophagy / C2C12 / Optineurin / 筋萎縮 / 筋萎縮性側索硬化症 / 移植・再生医療 / 脳神経疾患 Less
  • Research Projects

    (9 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (19 People)
  •  ワゴンホイール効果を応用したパーキンソン病等による思考緩慢の測定法開発と臨床応用

    • Principal Investigator
      江里口 誠
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      SAGA-KEN MEDICAL CENTRE KOSEIKAN
  •  Harnessing brain cortex-derived molecular data to unravel the mechanism underlying the APOE4-associated development of dementia

    • Principal Investigator
      Yamazaki Yu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Hiroshima University
  •  Development of cellular models of Alzheimer-type tauopathy with tau aggregatesPrincipal Investigator

    • Principal Investigator
      Takahashi Tetsuya
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Hiroshima International University
      Hiroshima University
  •  Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke

    • Principal Investigator
      Hosomi Naohisa
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Hiroshima University
  •  The molecular functions of Optineurin in the ALS pathogenesis

    • Principal Investigator
      NAGANO YOSHITO
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University
  •  Analyses on the mode of proteolysis and aggregation of synphilin-1 that constitutes the core of Lewy bodiesPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Tetsuya
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University
  •  Optimal therapeutic approach on ischemic brain insult using bone marrow stromal cells cultured under simulated microgravity

    • Principal Investigator
      MATSUMOTO Masayasu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University
  •  Establishment of regenerative medical technique on ischemic brain injury through optimal manipulation ofintrinsic and/or ES derived neuronal stem cell

    • Principal Investigator
      MATSUMOTO Masayasu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University
  •  Analysis on aggregation formation by novel Lewy body component Siah-1 complementary to ParkinPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Tetsuya, 山下 拓史
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Hiroshima University

All 2022 2011 2010 2009 2008 2006

All Journal Article Presentation

  • [Journal Article] Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process2022

    • Author(s)
      Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki, Morino Hirofumi, Maruyama
    • Journal Title

      Frontiers in Molecular Neuroscience

      Volume: - Pages: 804702-804702

    • DOI

      10.3389/fnmol.2022.804702

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07974, KAKENHI-PROJECT-21K17512, KAKENHI-PROJECT-20H03578
  • [Journal Article] Lifetime risk of stroke and impact of hypertension : estimates from the adult health study in Hiroshima and Nagasaki2011

    • Author(s)
      Takahashi I, et al
    • Journal Title

      Hypertens Res

      Volume: 34 Issue: 5 Pages: 649-654

    • DOI

      10.1038/hr.2011.7

    • NAID

      10031163232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Lifetime risk of stroke and impact of hypertension : estimates from the adult health study in Hiroshima and Nagasaki2011

    • Author(s)
      Takahashi I, Geyer SM, Nishi N, Ohshita T, Takahashi T, Akahoshi M, Fujiwara S, Kodama K, Matsumoto M.
    • Journal Title

      Hypertens Res

      Volume: 34(5) Pages: 649-54

    • NAID

      10031163232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Simulated Microgravity Maintains the Undifferentiated State and Enhances the Neural Repair Potential of Bone Marrow Stromal Cells2011

    • Author(s)
      Yuge L, Sasaki A, Kawahara Y, Wu SL, Matsumoto M, Manabe T, Kajiume T, Takeda M, Magaki T, Takahashi T, Kurisu K, Matsumoto M.
    • Journal Title

      Stem Cells Dev

      Volume: 20(5) Pages: 893-900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Granulo vacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurode generative disorders2011

    • Author(s)
      Yamazaki Y, Matsubara T, Takahashi T, Kurashige T, Dohi E, Hiji M, NaganoY, Yamawaki T, Matsumoto M.
    • Journal Title

      PLoS One

      Volume: 6(11)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] The pathophysiology of prospective memory failure after diffuse axonal injury-lesion-symptom analysis using diffusion tensor imaging2010

    • Author(s)
      Kondo K, Maruishi M, Ueno H, SawadaK, Hashimoto Y, Ohshita T, TakahashiT, Ohtsuki T, Matsumoto M.
    • Journal Title

      BMC Neurosci

      Volume: 11 Pages: 147-147

    • NAID

      120002753723

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Yuge L, Sasaki A, Kawahara Y, Wu SL, Matsumoto M, Manabe T, Kajiume T, Takeda M, Magaki T, Takahashi T, Kurisu K, Matsumoto M.2010

    • Author(s)
      Yuge L, Sasaki A, Kawahara Y, Wu SL, Matsumoto M, Manabe T, Kajiume T, Takeda M, Magaki T, Takahashi T, Kurisu K, Matsumoto M.
    • Journal Title

      20

      Pages: 893-900

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] SakaiN. Mutant protein kinase C gamma that causes spinocerebellar ataxia type 14(SCA14) is selectively degraded by autophagy2010

    • Author(s)
      Yamamoto K, Seki T, Adachi N, Takahashi T, Tanaka S, Hide I, Saito N.
    • Journal Title

      Genes Cells

      Volume: 15(5) Pages: 425-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] The pathophysiology of prospective memory failure after diffuse axonal injury-lesion-symptom analysis using diffusion tensor imaging.2010

    • Author(s)
      Kondo K, Maruishi M, Ueno H, Sawada K, Hashimoto Y, Ohshita T, Takahashi T, Ohtsuki T, Matsumoto M.
    • Journal Title

      BMC Neurosci 11

      Pages: 147-147

    • NAID

      120002753723

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] Immunopositivity for ESCRT-IIIsubunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer' s disease hippocampus2010

    • Author(s)
      Yamazaki Y, Takahashi T, Hiji M, Kurashige T, Izumi Y, Yamawaki T, Matsumoto M.
    • Journal Title

      Neurosci Lett

      Volume: 477(2) Pages: 86-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Deletion of Herp facilitates degradation of cytosolic proteins2010

    • Author(s)
      Miura H, Hashida K, Sudo H, Awa Y, Takarada-Iemata M, Kokame K, Takahashi T, Matsumoto M, Kitao Y, Hori O.
    • Journal Title

      Genes Cells

      Volume: 15(8) Pages: 843-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar de generation of neurons in the Alzheimer's disease hippocampus2010

    • Author(s)
      Yamazaki, Takahashi, et al.
    • Journal Title

      Neuroscience Letters (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11) C-AC-5216.2009

    • Author(s)
      Miyoshi M, Ito H, Arakawa R, Takahashi H, Takano H, Higuchi M, Okumura M, Otsuka T, Kodaka F, Sekine M, Sasaki T, Fujie S, Seki C, Maeda J, Nakao R, Zhang MR, Fukumura T, Matsumoto M, Suhara T.
    • Journal Title

      J Nucl Med 50

      Pages: 1095-1101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] Diagonal ear-lobe crease is correlated with atherosclerotic changes in carotid arteries.2009

    • Author(s)
      Shrestha I, Ohtsuki T, Takahashi T, Nomura E, Kohriyama T, Matsumoto M.
    • Journal Title

      Circ J. 73

      Pages: 1945-1949

    • NAID

      10025936498

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] Association between central systolic blood pressure, white matter lesions in cerebral MRI and carotid atherosclerosis.2009

    • Author(s)
      Shrestha I, Takahashi T, Nomura E, Ohtsuki T, Ohshita T, Ueno H, Kohriyama T, Matsumoto M.
    • Journal Title

      Hypertens Res 32

      Pages: 869-874

    • NAID

      10026123715

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] 脳血管障害のゲノミックス2009

    • Author(s)
      高橋哲也, 松本昌泰
    • Journal Title

      老年精神医学雑誌 20

      Pages: 980-988

    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] 脳梗塞の分子病態と標的分子2009

    • Author(s)
      高橋哲也, 松本昌泰
    • Journal Title

      実験医学 27

      Pages: 949-954

    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Diagonal ear-lobe crease is correlated with at herosclerotic changes in carotid arteries2009

    • Author(s)
      Isha S, Ohtsuki T, Takahashi T, Nomura E, Kohriyama T, Matsumoto M
    • Journal Title

      Circulation J

      Volume: 73 Pages: 1945-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Association betweencentral systolic blood pressure, whitematter lesions in cerebral MRI and carotid atherosclerosis2009

    • Author(s)
      Shrestha I, Takahashi T, Nomura E, Ohtsuki T, Ohshita T, Ueno H, Kohriyama T, Matsumoto M.
    • Journal Title

      Hypertens Res

      Volume: 32 : 8 Pages: 69-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] 新規GFAP遺伝子変異(S398F)を認めた成人型 Alexander 病の1例2009

    • Author(s)
      末田芳雅, 高橋哲也, ら
    • Journal Title

      臨床神経学 49

      Pages: 358-363

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] 新規GFAP遺伝子変異(S398F)を認めた成人型Alexander病の1例2009

    • Author(s)
      末田芳雅, 高橋哲也, 越智一秀, 大槻俊輔, 滑川道人, 郡山達男, 瀧山嘉久, 松本昌泰
    • Journal Title

      臨床神経

      Volume: 49(6) Pages: 358-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Journal Article] Synphilin-1 transgenic mice exhibit mild motor impairments.2008

    • Author(s)
      Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M.
    • Journal Title

      Neurosci Lett. 445

      Pages: 12-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] Abundance of aspargynyl-hydroxylase FIH is regulated by Siah-1 under normoxic conditions.2008

    • Author(s)
      Fukuba H, Takahashi T, Jin HG, Kohriyama T, Matsumoto M.
    • Journal Title

      Neurosci Lett 433

      Pages: 209-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease : TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin.2008

    • Author(s)
      Hiji M, Takahashi T, Fukuba H, Yamashita H, Kohriyama T, Matsumoto M.
    • Journal Title

      Acta Neuropathol. 116

      Pages: 183-191

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390246
  • [Journal Article] Interactions of Synphilin-1 with phospholipids and lipid membranes.2006

    • Author(s)
      Takahashi T
    • Journal Title

      FEBS Lett. 580(18)

      Pages: 4479-4484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590880
  • [Journal Article] Interactions of Synphilin-1 with phospholipids and lipid membranes.2006

    • Author(s)
      Takahashi T, et al.
    • Journal Title

      FEBS Lett. 580(18)

      Pages: 4479-4484

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590880
  • [Journal Article] Interactions of Synphilin-1 with phospholipids and lipid membranes2006

    • Author(s)
      Takahashi T et al.
    • Journal Title

      FEBS Letters 580

      Pages: 4479-4484

    • Data Source
      KAKENHI-PROJECT-18390258
  • [Presentation] 顆粒空胞変性は神経原線維変化の随伴所見か2011

    • Author(s)
      高橋哲也、倉重毅志、山崎雄、日地正典、山脇健盛、松本昌泰
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] 顆粒空胞変性は神経原線維変化の随伴所見か?2011

    • Author(s)
      高橋哲也
    • Organizer
      第52回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] 後骨間神経に「くびれ」を呈し、神経剥離術が有効であった1症例2010

    • Author(s)
      高橋哲也、砂川融、越智一秀、山脇健盛、郡山達男、松本昌泰
    • Organizer
      第28回日本神経治療学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] Granulovacuolar degenerations areassociated with taupathology2010

    • Author(s)
      Tomoyasu Matsubara, TetsuyaTakahashi, Takashi Kurashige, YuuYamazaki, Masanori Hiji, YuishinIzumi, Takemori Yamawaki, Masayasu Matsumoto
    • Organizer
      International congress ofneuropathology
    • Place of Presentation
      Salzburg, Austria
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] 運動ニューロン病におけるエンドソーム関連蛋白の免疫染色性2009

    • Author(s)
      高橋哲也, ら
    • Organizer
      日本神経学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] パーキンソン病患者におけるGERD(gastro-esophagealreflux disease)有病率について2009

    • Author(s)
      高橋哲也
    • Organizer
      第3回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21591085
  • [Presentation] 運動ニューロン病におけるエンドソーム関連蛋白の免疫染色性2009

    • Author(s)
      高橋哲也、日地正典、郡山達男、松本昌泰
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-21591085
  • 1.  MATSUMOTO Masayasu (20192346)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 23 results
  • 2.  OHTSUKI Toshiho (20418792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  YAMASHITA Hiroshi (20311813)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 4.  YUGE Rui (20263676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  TAHARA Hidetoshi (00271065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAGANO YOSHITO (50397973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAWAKAMI Hideshi (70253060)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HATTORI Nobutaka (80218510)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  Hosomi Naohisa (70363190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Yamazaki Yu (70866243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  辻田 麻紀 (10253262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  神沼 修 (80342921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  田中 茂 (20512651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  大古 善久 (10304007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  江里口 誠 (70404134)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  永山 寛 (00322511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  堀川 悦夫 (10155004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  高守 史子 (20833528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  YAO Tso-Pang
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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