TAKAHASHI MASANOBU 高橋雅信

… Alternative Names

TAKAHASHI Masanobu 高橋雅信

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Researcher Number	00447161
Other IDs
Affiliation (Current)	2025: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 医学系研究科, 准教授 2017 – 2021: 東北大学, 加齢医学研究所, 准教授 2014 – 2016: 東北大学, 大学病院, 講師 2013: 東北大学, 大学病院, 助教 2008 – 2011: 東北大学, 病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 53010:Gastroenterology-related / Gastroenterology / Tumor diagnostics Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Gastroenterology / Laboratory medicine
Keywords	Principal Investigator BRAF / 大腸がん / miRNA / 大腸癌 / 治療開発 / non-coding RNA / BRAF阻害薬 / Mcl1 / colorectal cancer / 発がん … More / BRAF変異 / 抗EGFR抗体 / microRNA / BRAF遺伝子 / 大腸がん発がん / MSI / CIMP … More Except Principal Investigator 大腸癌 / DNAメチル化 / 薬剤耐性 / 抗EGFR抗体薬 / 高DNAメチル化型大腸癌 / エピジェネティクス / 診断と治療 / 分子機構 / 免疫学的微小環境 / シグナル伝達異常 / 薬剤抵抗性克服 / DNA高メチル化型大腸癌 / miR-193a-3p / 薬剤感受性 / BRAF変異型大腸癌 / 分子標的治療薬 / バイオマーカー / 抗がん薬 / メチル化 / 下部消化管学 / 感受性予測 / 再発予測 / 分子マーカー / 予後予測 / 抗がん剤感受性予測 / 腫瘍検査学 Less

Developing new molecularly targeted therapy for BRAF-mutated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  高橋雅信
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Identification of alterations in non-coding RNA and development of novel therapeutic strategy for BRAF-mutated colorectal cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI MASANOBU
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Research on pathogenesis of DNA-highly methylated type colorectal cancer and the development of diagnosis and treatment methods
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Analysis of non-coding RNA involved in tumorigenesis of colorectal cancer with poor prognosis, and discovery of novel therapy using non-coding-RNA-related mechanismPrincipal Investigator
- Principal Investigator
  
  Takahashi Masanobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku University
Functional analysis of small RNAs involved in tumorigenesis of a new molecular subtype of colorectal cancer, and investigation of their new molecular targetsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI MASANOBU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Study on anti-EGFR antibody-resistant conquest of high DNA methylation type colorectal cancer
- Principal Investigator
  
  Ishioka Chikashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
Identification and functional analysis of miRNAs that are involved in carcinogenesis of a new molecular subgroup of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Masanobu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tohoku University
Development of predictive marker of drug therapy for colorectal cancer by epigenetic analysis of circulating DNA
- Principal Investigator
  
  SHIMODAIRA Hideki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Screening molecular markers for prediction of recurrence and prognosis of colorectal cancer.
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University

[Journal Article] Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)2024
- Author(s)
  Hiroo Imai, Chikashi Ishioka et al.
- Journal Title
  
  BMC Cancer
  
  Volume: 24(1) Issue: 1 Pages: 260-260
- DOI
  10.1186/s12885-024-11973-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07293, KAKENHI-PROJECT-21K07169
[Journal Article] Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer2023
- Author(s)
  Yoshino T.、Cervantes A.、Bando H.、other 24 authors.、Takahashi M.、et al.
- Journal Title
  
  ESMO Open
  
  Volume: 8 Issue: 3 Pages: 101558-101558
- DOI
  10.1016/j.esmoop.2023.101558
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07169
[Journal Article] TP53 Gain-of-Function Mutation is a Poor Prognostic Factor in High-Methylated Metastatic Colorectal Cancer.2023
- Author(s)
  Wakayama S, Ouchi K, Takahashi S, Yamada Y, Komatsu Y, Shimada K, Yamaguchi T, Shirota H, Takahashi M, Ishioka C.
- Journal Title
  
  Clin Colorectal Cancer
  
  Volume: 22(3) Issue: 3 Pages: 327-328
- DOI
  10.1016/j.clcc.2023.06.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07183, KAKENHI-PROJECT-21K07169
[Journal Article] Management of patients with presumed germline pathogenic variant from tumor-only genomic sequencing: A retrospective analysis at a single facility2023
- Author(s)
  Kawamura Maako.....Yasuda Jun, et al.
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 68 Issue: 6 Pages: 399-408
- DOI
  10.1038/s10038-023-01133-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-22K07183, KAKENHI-PROJECT-21K07169
[Journal Article] Clinical decisions by the molecular tumor board on comprehensive genomic profiling tests in Japan: A retrospective observational study.2023
- Author(s)
  Shirota H, Komine K, Takahashi M, Takahashi S, Miyauchi E, Niizuma H, Tada H, Shimada M, Niihori T, Aoki Y, Sugiyama I, Kawamura M, Yasuda J, Suzuki S, Iwaya T, Saito M, Saito T, Shibata H, Furukawa T, Ishioka C.
- Journal Title
  
  Cancer Med.
  
  Volume: 12(5) Pages: 6170-6181
- DOI
  10.3389/fonc.2023.1230731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07183, KAKENHI-PROJECT-21K07169
[Journal Article] Phase II study of biweekly cetuximab plus mFOLFOX6 or mFOLFIRI as second-line treatment for metastatic colorectal cancer and exploratory analysis of associations between DNA methylation status and the efficacy of the anti-EGFR antibody: T-CORE12012023
- Author(s)
  Takahashi Shin、Ouchi Kota、Sakamoto Yasuhiro、et al.
- Journal Title
  
  Journal of Gastrointestinal Oncology
  
  Volume: 14 Issue: 2 Pages: 676-691
- DOI
  10.21037/jgo-22-862
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07248, KAKENHI-PROJECT-18K09270, KAKENHI-PROJECT-21K07169
[Journal Article] FOLFIRI Chemotherapy for Patients With Metastatic Urachal Carcinoma.2023
- Author(s)
  Taniguchi SH, Komine K, Takenaga N, Yoshida Y, Sasaki K, Kawamura Y, Kasahara Y, Ouchi K, Imai H, Saijo K, Shirota H, Takahashi M, Ishioka C.
- Journal Title
  
  Anticancer Res.
  
  Volume: 43(12) Issue: 12 Pages: 5699-5704
- DOI
  10.21873/anticanres.16775
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07183, KAKENHI-PROJECT-21K07169
[Journal Article] A modified MethyLight assay predicts the clinical outcomes of anti-epidermal growth factor receptor treatment in metastatic colorectal cancer2022
- Author(s)
  Ouchi K, Takahashi S, Okita A, Sakamoto Y, Muto O, Amagai K, Okada T, Ohori H, Shinozaki E, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 3 Pages: 1057-1068
- DOI
  10.1111/cas.15252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03508
[Journal Article] Advanced colorectal cancer subtypes (aCRCS) help select oxaliplatin-based or irinotecan-based therapy for colorectal cancer.2021
- Author(s)
  Takahashi S，Sakamoto Y，Denda T，Takashima A，Komatsu Y，Nakamura M，Ohori H，Yamaguchi T，Kobayashi Y，Baba H，Kotake M，Amagai K，Kondo H，Shimada K，Sato A，Yuki S，Okita A，Ouchi K，Komine K，Watanabe M，Morita S，Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 4 Pages: 1567-1578
- DOI
  10.1111/cas.14841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Journal Article] Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer2021
- Author(s)
  Hiraide S, Takahashi M, Yoshida Y, Yamada H, Komine K, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 9 Pages: 3856-3870
- DOI
  10.1111/cas.15075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03508, KAKENHI-PROJECT-21K07169
[Journal Article] Consensus molecular subtypes classification of colorectal cancer2018
- Author(s)
  Okita, A.，Takahashi, S.，Ouchi, K.，Inoue, M.，Yamada, Y.，Ishioka, C.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 4 Pages: 18698-18711
- DOI
  10.1007/s10147-018-1261-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-16K07106
[Journal Article] The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: A retrospective, single institutional study.2017
- Author(s)
  Takahashi M, Takahashi M, Komine K, Yamada H, Kasahara Y, Chikamatsu S, Okita A, Ito S, Ouchi K, Okada Y, Imai H, Saijo K, Shirota H, Takahashi S, Mori T, Shimodaira H, Ishioka C.
- Journal Title
  
  PLoS One.
  
  Volume: 12(6) Issue: 6 Pages: e0179694-e0179694
- DOI
  10.1371/journal.pone.0179694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07106, KAKENHI-PROJECT-16K19304, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-16K10488
[Journal Article] Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis.2017
- Author(s)
  Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.
- Journal Title
  
  PLoS One.
  
  Volume: 12(5) Issue: 5 Pages: e0176972-e0176972
- DOI
  10.1371/journal.pone.0176972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07106, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-16K10488
[Journal Article] Efficacy and safety of denosumab versus zoledronic acid in delaying skeletal-related events in patients with gastrointestinal cancer, pancreas-biliary system cancer, and other rare cancers.2017
- Author(s)
  Imai H, Saijo K, Yamada H, Ohuchi K, Okada Y, Komine K, Takahashi M, Takahashi S, Takahashi M, Shimodaira H, Ishioka C.
- Journal Title
  
  J Bone Oncol
  
  Volume: 6 Pages: 37-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08962
[Journal Article] microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.2017
- Author(s)
  Takahashi, H.，Takahashi, M.，Ohnuma, S.，Unno, M.，Yoshino, Y.，Ouchi, K.，Takahashi, S.，Yamada, Y.，Shimodaira, H.，Ishioka, C.:
- Journal Title
  
  BMC Cancer
  
  Volume: 17 Issue: 1 Pages: 723-727
- DOI
  10.1186/s12885-017-3739-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-15K10128
[Journal Article] CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer.2016
- Author(s)
  Zhang, X.，Shimodaira, H.，Soeda, H.，Komine, K.，Takahashi, H.，Ouchi, K.，Inoue, M.，Takahashi, M.，Takahashi, S.，Ishioka, C.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 21 Issue: 6 Pages: 1091-1101
- DOI
  10.1007/s10147-016-1017-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-26460958
[Journal Article] DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.2015
- Author(s)
  Ouchi K, Takahashi S, Yamada Y, Tsuji S, Tatsuno K, Takahashi H, Takahashi N, Takahashi M, Shimodaira H, Aburatani H, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 12 Pages: 1722-1729
- DOI
  10.1111/cas.12827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-26460958, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-15H04307
[Journal Article] Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia coli Strain.2015
- Author(s)
  Komine K, Shimodaira H, Takao M, Soeda H, Zhang X, Takahashi M, Ishioka C.
- Journal Title
  
  Human Mutation
  
  Volume: 36 Issue: 7 Pages: 704-711
- DOI
  10.1002/humu.22794
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-26460958
[Journal Article] Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF1262011
- Author(s)
  Sakamoto Y, Kato S, Takahashi M, Okada Y, Yasuda K, Watanabe G, Imai H, Sato A, Ishioka C
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 799-807
- NAID
  10029292419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Phase I/II study of sequential therapy with irinotecan and S-1 for metastatic colorectal cancer2009
- Author(s)
  Yoshioka T, Kato S, Gamoh M, Chiba N, Suzuki T, Sakayori N, Kato S, Shibata H, Shimodaira H, Otsuka K, Kakudo Y, Takahashi S, Ishioka C
- Journal Title
  
  Br J Cancer
  
  Volume: 101 Pages: 1972-7
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Newly synthesized cur cumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009
- Author(s)
  Shibata, H., Yamakoshi, H., Sato, A., Ohori, H., Kakudo, Y., Kudo, C., Takahashi, Y., Watanabe, M. , Takano, H. , Ishioka, C. , Noda, T. , Iwabuchi, Y
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Pages: 956-60
- NAID
  10025146044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Prediction of breast cancer prognosis by gene expression profile of TP53 status2008
- Author(s)
  Takahashi, S., Moriya, T., Ishida, T., Shibata, H., Sasano, H., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci
  
  Volume: 99 Pages: 324-32
- NAID
  10024002457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Patent] 特許権2022
- Inventor(s)
  高橋雅信
- Industrial Property Rights Holder
  高橋雅信
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K07169
[Patent] がんの予後予測方法2009
- Inventor(s)
  石岡千加史、高橋信
- Industrial Property Rights Holder
  東北大学
- Acquisition Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] Tretinoin enhances the efficacy of combined BRAF, MEK, and EGFR inhibition in BRAFV600E colorectal cancer cells2024
- Author(s)
  吉田裕也, 高橋雅信, 沼倉龍之助, 谷口桜, 小峰啓吾, 石岡千加史
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07169
[Presentation] The functional roles of miRNA-193a-3p in colorectal cancer2021
- Author(s)
  Sakura Hiraide, Masanobu Takahashi, Yuya Yoshida, Keigo Komine, Chikashi Ishioka
- Organizer
  AACR2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07993
[Presentation] The functional roles of miRNA-193a-3p in colorectal cancer.2021
- Author(s)
  Hiraide S, Takahashi M, Yoshida Y, Komine K, Ishioka C.
- Organizer
  AACR Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] miR-X acts as a tumor-suppressor and sensitizes BRAF-mutated colorectal cancer cell lines to dabrafenib and trametinib2020
- Author(s)
  平出桜、高橋雅信、小峰啓吾、石岡千加史
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07993
[Presentation] 高メチル化大腸がんが抗EGFR抗体薬抵抗性となる分子生物学的メカニズムの探索2020
- Author(s)
  大内康太，高橋信，沖田啓，大槻泰史，石岡千加史
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Analysis of consensus molecular subtypes (CMS) classification in the TRICOLORE trial: A randomized phase 3 trial of S-1 and irinotecan plus bevacizumab versus mFOLFOX6 or CapeOX plus bevacizumab as first-line treatment for metastatic colorectal cancer．2020
- Author(s)
  1.Yuki S，Gamoh M，Denda T，Takashima A，Takahashi S，Nakamura M，Ohori H，Yamaguchi T，Kobayashi Y，Baba H，Kotake M，Amagi K，Kondo H，Shimada K，Sato A，Ishioka C，Komine K，Ouchi K，Morita S，Komatu Y
- Organizer
  ASCO 2020 Gastrointestinal Cancers Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Development of an in vitro diagnostic test to predict the clinical outcome of anti-EGFR treatment based on DNA methylation status.2020
- Author(s)
  Ouchi K，Takahashi S，Ishioka C
- Organizer
  7th US-Japan Workshop on Biomarkers for Cancer Early Detection.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Development of novel in vitro diagnostics to predict the efficacy of anti-EGFR treatment based on DNA methylation status．2019
- Author(s)
  4.大内康太，高橋信，沖田啓，坂本康寛，武藤理，天貝賢二，岡田恭穂，大堀久詔，篠崎英司，蒲生真紀夫，石岡千加史
- Organizer
  第 17 回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] The consensus molecular subtypes of colorectal cancer as a predictive factor for chemotherapies against metastatic colorectal cancer．2018
- Author(s)
  Okita, A.，Takahashi, S.，Ouchi, K.，Inoue, M.，Yamada, Y.，Ishioka, C
- Organizer
  2018 Gastrointestinal Cancers Symposium，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] Consensus molecular subtypes（CMS）に基づく、進行・再発大腸癌に対する最適な化学療法の検討2017
- Author(s)
  沖田啓，高橋信，大内康太，山田英晴，笠原佑記，近松園子，高橋秀和，高橋雅信，下平秀樹，石岡千加史
- Organizer
  第15回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] 大腸がんに対する抗EGFR抗体薬の効果を予測する新規バイオマーカー・DNAメチル化状態診断キットの開発．2017
- Author(s)
  石岡千加史，高橋信，大内康太，高橋雅信，永江玄太
- Organizer
  ジャパン・キャンサーリサーチ・プロジェクト　平成28年度企業向け成果発表会
- Place of Presentation
  アキバホール（東京都・秋葉原）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] 進行大腸癌の新しい分子標的薬とバイオマーカーの開発．2017
- Author(s)
  石岡千加史，西條憲，高橋信，大内康太，今井源，高橋雅信
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] microRAN-193a-3p acts as a tumor suppressor in BRAF-mutated colorectal cancer．2016
- Author(s)
  Takahashi, H.，Takahashi, M.，Takahashi, S.，H., S.，Ishioka, C.
- Organizer
  AACR 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] microRNA-193a-3p acts as a tumor suppressor in BRAF-mutated colorectal cancer2016
- Author(s)
  1.Takahashi H, Takahashi M, Takahashi S, Shimodaira H, Ishioka, C
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08962
[Presentation] BRAF変異陽性大腸癌において癌抑制miRNAとして機能するmiRNA-Xの同定2014
- Author(s)
  高橋秀和, 高橋雅信, 下平秀樹, 高橋信, 石岡千加史
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25870048
[Presentation] A randomized pilot study comparing safety and efficacy of irinotecan plus S-1 (IRIS)plus bevacizumab (BV)and modified (m)FOLFIRI plus BV in patients (pts)with metastatic colorectal cancer (marc): First report of T-CORE07022011
- Author(s)
  Kato, S. , Andoh, H. , Gamoh, M. , Yamaguchi, T. , Murakawa, Y. , Sasaki, Y. , Takahashi, S. , Shimodaira, H. , Yoshioka, T. , Ishioka, C.
- Organizer
  2011 Gastrointestinal Cancers Symposium
- Place of Presentation
  Florida・Orland world Center Marriott.General Poster Session C
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] 石岡千加史:大腸癌におけるEGFRシグナル伝達経路の変異とオキサリプラチン、イリノテカンの治療成績2011
- Author(s)
  添田大司, 下平秀樹, 渡辺みか, 森隆弘, 角道祐一, 高橋信, 秋山聖子, 小峰啓吾, 加藤俊介
- Organizer
  第108回日本内科学会学術講演会
- Place of Presentation
  東京で予定されていた学術講演会は、震災のため開催されず
- Year and Date
  2011-02-20
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] EGFR陽性の治癒切除不能な進行再発結腸・直腸癌に対するcetuximabおよび塩酸イリノテカン併用療法のKRAS変異有無による有効性、安全性の前向き試験2011
- Author(s)
  森隆弘、添田大司、蒲生真紀夫、高橋信、角道祐一、天貝賢二、鈴木貴夫、村川康子、加藤誠之、伊藤重豪、渡邊みか、山口拓洋、下平秀樹、加藤俊介、石岡千加史
- Organizer
  第9回日本臨床腫瘍学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] 石岡千加史:大腸癌における抗EGFR抗体薬のバイオマーカーEGFRシグナル伝達因子検索の意義2010
- Author(s)
  添田大司, 下平秀樹, 小峰啓吾, 加藤俊介, 森隆弘, 角道祐一, 大堀久詔, 高橋信, 秋山聖子, 鈴木貴夫, 蒲生真紀夫, 渡辺みか, 岩間憲行, 鈴木博義
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] 東北大学病院化学療法カンファレンスの現状と課題2010
- Author(s)
  下平秀樹、森隆弘、角道祐一、高橋信, 他
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-28
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] MSH2のintron5のsplice donor siteに変異を認めたHNPCCの一家系2009
- Author(s)
  高橋雅信
- Organizer
  第15回日本家族性腫瘍学会学術集会
- Place of Presentation
  秋葉原コンベンションホール(東京都)
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] Status of EGFR related signal transduction for predicting response to anti-EGFR therapy in advanced colorectal cancer2009
- Author(s)
  Shimodaira, H., Soeda, H., Takahashi, M., Ishioka, C.
- Organizer
  The 68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] 仮説に基づくマーカーと仮説に基づかないマーカー2009
- Author(s)
  石岡千加史, 高橋信, 添田大司, 下平秀樹
- Organizer
  第47回日本癌治療学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] Status of EGFR related signal transduction for predicting response to anti-EGFR therapy in advanced colorectal cancer.2009
- Author(s)
  Shimodaira H., Soeda H., Komine K., Takahashi M., Ishioka C
- Organizer
  68th Annual Meeting of the Japanese Cancer Association International Sessions
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] Genetic alterations in colorectal cancer associated with the efficacy of anti-EGFR antibody or cancer predisposition.2009
- Author(s)
  Shimodaira, H., Soeda, H., Takahashi, M., et al.
- Organizer
  The 14^<th> Korea-Japan Cancer Research Workshop
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] 当院における進行・再発大腸癌に対するKRAS遺伝子解析の実際.2009
- Author(s)
  添田大司, 下平秀樹, 高橋雅信, 小峰啓吾, 加藤俊介, 他
- Organizer
  第47回日本癌治療学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21590802
[Presentation] Genetic alterations in colorectal cancer associated with the efficacy of anti-EGFR antibody or cancer predisposition2009
- Author(s)
  Shimodaira, H., Soeda, H., Takahashi, M., Ishioka, C.
- Organizer
  The 14th Korea-Japan Cancer Research Workshop
- Place of Presentation
  金沢
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-21590802

1. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
2. TAKAHASHI Shin (20431570)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. 大内康太 (50781291)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. KOBAYASHI Akihiro

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIMODAIRA Hideki (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. TAKAHASHI Hidekazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. OKITA Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 城田英和

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 今井源

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 安田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI MASANOBU 高橋 雅信

TAKAHASHI Masanobu 高橋 雅信

Research Projects

Research Products

Co-Researchers

Developing new molecularly targeted therapy for BRAF-mutated colorectal cancerPrincipal Investigator

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Identification of alterations in non-coding RNA and development of novel therapeutic strategy for BRAF-mutated colorectal cancerPrincipal Investigator

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Research on pathogenesis of DNA-highly methylated type colorectal cancer and the development of diagnosis and treatment methods

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Analysis of non-coding RNA involved in tumorigenesis of colorectal cancer with poor prognosis, and discovery of novel therapy using non-coding-RNA-related mechanismPrincipal Investigator

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Functional analysis of small RNAs involved in tumorigenesis of a new molecular subtype of colorectal cancer, and investigation of their new molecular targetsPrincipal Investigator

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Study on anti-EGFR antibody-resistant conquest of high DNA methylation type colorectal cancer

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Identification and functional analysis of miRNAs that are involved in carcinogenesis of a new molecular subgroup of colorectal cancerPrincipal Investigator

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Development of predictive marker of drug therapy for colorectal cancer by epigenetic analysis of circulating DNA

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Screening molecular markers for prediction of recurrence and prognosis of colorectal cancer.

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[Journal Article] Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)2024

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[Journal Article] Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer2023

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[Journal Article] TP53 Gain-of-Function Mutation is a Poor Prognostic Factor in High-Methylated Metastatic Colorectal Cancer.2023

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[Journal Article] Management of patients with presumed germline pathogenic variant from tumor-only genomic sequencing: A retrospective analysis at a single facility2023

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[Journal Article] Clinical decisions by the molecular tumor board on comprehensive genomic profiling tests in Japan: A retrospective observational study.2023

TAKAHASHI MASANOBU 高橋雅信

TAKAHASHI Masanobu 高橋雅信