Ishioka Chikashi 石岡千加史

… Alternative Names

ISHIOKA Chikashi 石岡千加史

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Researcher Number	60241577
Other IDs
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Affiliation (Current)	2025: 東北大学, 大学病院, 学術研究員 2025: 東北大学, 医学系研究科, 教授 2025: 東北大学, 加齢医学研究所, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 医学系研究科, 教授 2019: 東北大学, 加齢医学研究所, 教授 2012 – 2017: 東北大学, 加齢医学研究所, 教授 2003 – 2010: Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 1996 – 2002: 東北大学, 加齢医学研究所, 助教授 … More 2001: 東北大, 加齢医学研究所, 助教授 1997: 東北大, 加齢医学研究所, 講師 1996 – 1997: 東北大学, 加齢医学研究所, 講師 Less
Review Section/Research Field	Principal Investigator Human genetics / Gastroenterology / Clinical oncology / Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics / Molecular biology / Laboratory medicine Except Principal Investigator Gastroenterology / Medium-sized Section 35:Polymers, organic materials, and related fields … More / Medical sociology / Human genetics / 内科学一般 / Laboratory medicine Less
Keywords	Principal Investigator hMLH1 / 大腸癌 / p53 / MLH1 / 機能診断 / DNAメチル化 / 薬剤耐性 / 抗EGFR抗体薬 / 高DNAメチル化型大腸癌 / second-site suppressor … More / super p53 / genetic diagnosis / APC / hMSH2 / functional analysis / Saccharomyces cerevisiae / 遺伝子診断 / 遺伝性大腸癌 / 出芽酵母 / ミスマッチ修復 / 分子標的治療薬 / missense mutation / MYH / BRCA1 / ミスセンス変異 / 機能解析 / PTEN / 機能 / 遺伝子変異 / 診断と治療 / 分子機構 / 免疫学的微小環境 / シグナル伝達異常 / 薬剤抵抗性克服 / DNA高メチル化型大腸癌 / miR-193a-3p / 薬剤感受性 / BRAF変異型大腸癌 / エピジェネティクス / バイオマーカー / 抗がん薬 / gastrointestinal cancer / 消化器癌 / comprehensive mutation library / 診断 / DNAミスマッチ修復 / 網羅的変異ライブラリー / 遺伝子診断法 / hereditary colon cancer / HNPCC / misnatch repair / 遺伝子機能 / 合成致死 / 変異p53 / HDAC / PI3K / がん / 創薬 / ＨＤＡＣ阻害薬 / PI3K阻害薬 / 感受性予測 / 再発予測 / 分子マーカー / 予後予測 / 抗がん剤感受性予測 / 腫瘍検査学 / 変異 / TP53 / 腫瘍関連遺伝子 / がん抑制遺伝子 / がん関連遺伝子 / BRCA2 / p63 … More Except Principal Investigator APC / p53 / APC遺伝子 / P53 / ナノ薬剤 / 抗がん剤 / 再沈法 / ドラッグデリバリーシステム / 意思決定 / 抗がん剤治療 / 腫瘍内科 / 病状認識 / コミュニケーション / 医師 / 化学療法 / 終末期医療 / がん / 緩和ケア / promoter / Sacharomyces Cererisiae / tumor suppressor geae p53 / 転写機能 / プロモーター / 出芽酵母 / 腫瘍抑制遺伝子p53 / beta-Catenin / APC gene / 大腸癌 / Wntシグナル / β-Catenin / stop codon assay / colorectal tumor / mismatch repair system / carcinogen / tumor suppressor gene / SC assay / Yeast / ストップコドンアッセイ法 / MSH2 / ミスマッチ修復遺伝子 / Immunohistochemistory / Rheumatoid arthritis / 免疫組織化学 / 慢性関節リウマチ / SaOS2,SF126 / 培養細胞 / 96穴プレート / ChIPアッセイ Less

がん細胞特有の刺激に応答し薬物を放出する新規抗がん薬ナノ粒子の開発
- Principal Investigator
  
  笠井均
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 35:Polymers, organic materials, and related fields
- Research Institution
  Tohoku University
Research on pathogenesis of DNA-highly methylated type colorectal cancer and the development of diagnosis and treatment methodsPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
End-of-life discussion between advanced cancer patients and physicians.
- Principal Investigator
  
  MIYASHITA MITSUNORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  Tohoku University
Study on anti-EGFR antibody-resistant conquest of high DNA methylation type colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Ishioka Chikashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
A search and optimization of the novel cancer molecules target drugs with PI3K/HDAC dual inhibitionPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Tohoku University
Search of mutant p53-specific target of cancer cellsPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Clinical oncology
- Research Institution
  Tohoku University
Screening molecular markers for prediction of recurrence and prognosis of colorectal cancer.Principal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
Development of functional assays for tumor-related genesPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
臨床応用に向けたクロマチン免疫沈降PCR法を用いたp53機能解析法の開発
- Principal Investigator
  
  加藤俊介
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
Development of p53-associated molecular devices for diagnosis and treatment of gastrointestinal cancerPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Changing of the promater selectivity by p53 point nutations
- Principal Investigator
  
  KATO Shunsuke
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
がん関連遺伝子変異の検出および機能評価法の開発Principal Investigator
- Principal Investigator
  
  石岡千加史
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
腫瘍関連遺伝子における遺伝子変異の機能評価Principal Investigator
- Principal Investigator
  
  石岡千加史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tohoku University
Establishment of a new strategy for colorectal cancer gene therapy by controlling Wnt-signal molecules
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Functional mapping of missens mutations in hMLH1 genePrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
Inactivation model of human Adenomatous Polyposis Coli gene by using budding yeast in vivo.
- Principal Investigator
  
  KANAMARU Ryonosuke
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Development of yeast-based screening method for cancer-related genes and its clinical applicationsPrincipal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  Tohoku University
Joint study on the DNA mismatch repair system : Functional analysis of the DNA mismatch repair genes using Saccharomyces cerevisiae.Principal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
Tumor inhibitory gene in rheumatoid arthritis
- Principal Investigator
  
  SHIBATA Shinobu, 高橋裕一
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Tohoku University
Development of a novel method for genetic diagnosis of hereditary colon cancer syndromes using yeast.Principal Investigator
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

[Book] がん分子標的治療薬開発におけるProof of concept日本がん分子標的治療学会, 曽根三郎, 鶴尾隆編がん分子標的治療研究実践マニュアル2009
- Author(s)
  石岡千加史
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17015002
[Book] 入門腫瘍内科学(編集委員), 秋田弘俊, 石岡千加史, 田村和夫, 中川和彦, 原田実根, 南博信編入門腫瘍内科学(直腸, 結腸癌)2009
- Author(s)
  秋田弘俊, 石岡千加史, 田村和夫, 中川和彦, 原田実根, 南博信
- Publisher
  篠原出版社
- Data Source
  KAKENHI-PROJECT-20390163
[Book] がん分子標的治療薬開発におけるProof of concept日本がん分子標的治療学会, 曽根三郎, 鶴尾隆編がん分子標的治療研究実践マニュアル2009
- Author(s)
  石岡千加史
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-20390163
[Book] 入門腫瘍内科学(編集委員), 秋田弘俊, 石岡千加史, 田村和夫, 中川和彦, 原田実根, 南博信編入門腫瘍内科学(直腸, 結腸癌)2009
- Author(s)
  秋田弘俊, 石岡千加史, 田村和夫, 中川和彦, 原田実根, 南博信
- Publisher
  篠原出版社
- Data Source
  KAKENHI-PROJECT-17015002
[Book] 第5章テーラーメイド医療の未来がんの個性と個別化帯刀益夫, 佐竹正延編加齢医学エイジング・ファイン2007
- Author(s)
  石岡千加史
- Publisher
  東北大学出版
- Data Source
  KAKENHI-PROJECT-17015002
[Book] A. プロテインキナーゼ阻害薬西條長宏編抗悪性腫瘍薬マニュアル2007
- Author(s)
  石岡千加史
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-17015002
[Book] 4. がん薬物療法の分子標的4)アポトーシス西條長宏編癌治療の新たな試み新編III2005
- Author(s)
  石岡千加史
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] A modified MethyLight assay predicts the clinical outcomes of anti-epidermal growth factor receptor treatment in metastatic colorectal cancer2022
- Author(s)
  Ouchi K, Takahashi S, Okita A, Sakamoto Y, Muto O, Amagai K, Okada T, Ohori H, Shinozaki E, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 3 Pages: 1057-1068
- DOI
  10.1111/cas.15252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03508
[Journal Article] Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer2021
- Author(s)
  Hiraide S, Takahashi M, Yoshida Y, Yamada H, Komine K, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 9 Pages: 3856-3870
- DOI
  10.1111/cas.15075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03508, KAKENHI-PROJECT-21K07169
[Journal Article] Advanced colorectal cancer subtypes (aCRCS) help select oxaliplatin-based or irinotecan-based therapy for colorectal cancer.2021
- Author(s)
  Takahashi S，Sakamoto Y，Denda T，Takashima A，Komatsu Y，Nakamura M，Ohori H，Yamaguchi T，Kobayashi Y，Baba H，Kotake M，Amagai K，Kondo H，Shimada K，Sato A，Yuki S，Okita A，Ouchi K，Komine K，Watanabe M，Morita S，Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 4 Pages: 1567-1578
- DOI
  10.1111/cas.14841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Journal Article] Consensus molecular subtypes classification of colorectal cancer2018
- Author(s)
  Okita, A.，Takahashi, S.，Ouchi, K.，Inoue, M.，Yamada, Y.，Ishioka, C.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 4 Pages: 18698-18711
- DOI
  10.1007/s10147-018-1261-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-16K07106
[Journal Article] microRNA-193a-3p is specifically down-regulated and acts as a tumor suppressor in BRAF-mutated colorectal cancer.2017
- Author(s)
  Takahashi, H.，Takahashi, M.，Ohnuma, S.，Unno, M.，Yoshino, Y.，Ouchi, K.，Takahashi, S.，Yamada, Y.，Shimodaira, H.，Ishioka, C.:
- Journal Title
  
  BMC Cancer
  
  Volume: 17 Issue: 1 Pages: 723-727
- DOI
  10.1186/s12885-017-3739-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-15K10128
[Journal Article] CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer.2016
- Author(s)
  Zhang, X.，Shimodaira, H.，Soeda, H.，Komine, K.，Takahashi, H.，Ouchi, K.，Inoue, M.，Takahashi, M.，Takahashi, S.，Ishioka, C.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 21 Issue: 6 Pages: 1091-1101
- DOI
  10.1007/s10147-016-1017-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04307, KAKENHI-PROJECT-26460958
[Journal Article] DNA methylation status as a biomarker of anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.2015
- Author(s)
  Ouchi K, Takahashi S, Yamada Y, Tsuji S, Tatsuno K, Takahashi H, Takahashi N, Takahashi M, Shimodaira H, Aburatani H, Ishioka C.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 12 Pages: 1722-1729
- DOI
  10.1111/cas.12827
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-26460958, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-15H04307
[Journal Article] Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors.2015
- Author(s)
  2.Saijo, K.，Imamura, J.，Narita, K.，Oda, A.，Shimodaira, H.，Katoh, T.，Ishioka, C.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.12585
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300339, KAKENHI-PROJECT-24590017, KAKENHI-PROJECT-25830110, KAKENHI-PROJECT-26460034, KAKENHI-PROJECT-15K07865
[Journal Article] Predicting the structures of complexes between phosphoinositide 3-kinase (PI3K) and romidepsin-related compounds for the drug design of PI3K/histone deacetylase dual inhibitors using computational docking and the ligand-based drug design approach.2014
- Author(s)
  Oda, A.，Saijo, K.，Ishioka, C.，Narita, K.，Katoh, T.，Watanabe, Y.，Fukuyoshi, S.，Takahashi, O.
- Journal Title
  
  J Mol Graph Model
  
  Volume: 54 Pages: 46-53
- DOI
  10.1016/j.jmgm.2014.08.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300339, KAKENHI-PROJECT-24590017, KAKENHI-PROJECT-26460034
[Journal Article] High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.2014
- Author(s)
  Imai H, Kato S, Sakamoto Y, Kakudo Y, Shimodaira H, Ishioka C.
- Journal Title
  
  Oncol Rep.
  
  Volume: 31 Issue: 3 Pages: 1043-1050
- DOI
  10.3892/or.2013.2953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501349, KAKENHI-PROJECT-24650642
[Journal Article] High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.2014
- Author(s)
  Imai H, Kato S, Sakamoto Y, Kakudo Y, Shimodaira H, Ishioka C.
- Journal Title
  
  Oncology Reports
  
  Volume: 31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650642
[Journal Article] Cur cumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis2011
- Author(s)
  Sato A, Kudo C, Yamakoshi H, Uehara Y, Ohori H, Ishioka C, Iwabuchi Y, Shibata H
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1045-51
- NAID
  10029293736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF1262011
- Author(s)
  Sakamoto Y, Kato S, Takahashi M, Okada Y, Yasuda K, Watanabe G, Imai H, Sato A, Ishioka C
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 799-807
- NAID
  10029292419
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination2010
- Author(s)
  Ransburgh, D. J., Chiba, N., Ishioka, C., Toland, A. E., Parvin, J. D
- Journal Title
  
  Cancer Res
  
  Volume: 70 Pages: 988-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination2010
- Author(s)
  Ransburgh, D.J., Chiba, N., Ishioka, C., Toland, A.E., Parvin, J. D
- Journal Title
  
  Cancer Res 70
  
  Pages: 988-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Phase II study of capecitabine and trastuzumab combination chemotherapy in patients with HER2 over expressing metastatic breast cancers resistant to both anthracyclines and taxanes2009
- Author(s)
  Ishida T, Kiba T, Takeda M, Matsuyama K, Teramukai S, Ishiwata R, Masuda N, Takatsuka Y, Noguchi S, Ishioka C, Fukushima M, Ohuchi N
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 64 Pages: 361-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] alphaB-crystallin : A novel p53-target gene required for p53-dependent apoptosis2009
- Author(s)
  Watanabe, G., Kato, S., Nakata, H., Ishida, T., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Pages: 2368-2375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] alphaB-crystallin: A novel p53-target gene required for p53-dependent apoptosis2009
- Author(s)
  Watanabe, G., Kato, S., Nakata, H., Ishida, T., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci 100
  
  Pages: 2368-2375
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer)patients using functional splicing assay2009
- Author(s)
  Naruse, H., Ikawa, N., Yamaguchi, K., Nakamura, Y., Arai, M., Ishioka, C., Sugano, K., Tamura, K., Tomita, N., Matsubara, N., Yoshida, T., Moriya, Y., Furukawa, Y
- Journal Title
  
  Fam Cancer
  
  Volume: 8 Pages: 509-517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Comparison of cisplatin and 5-fluorouracil chemotherapy protocols combined with concurrent radiotherapy for esophageal cancer2009
- Author(s)
  Sakayauchi T, Nemoto K, Ishioka C, Onishi H, Yamamoto M, Kazumoto T, Makino M, Yonekura R, Itami J, Sasaki S, Suzuki G, Hayabuchi N, Tamamura H, Onimaru R, Tamamoto T, Yamada S
- Journal Title
  
  Jpn J Radiol
  
  Volume: 27 Pages: 131-7
- NAID
  50007224857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Prospective comparison of surgery alone and chemo radiotherapy with selective surgery in resectable squamous cell carcinoma of the esophagus2009
- Author(s)
  Ariga H, Nemoto K, Miyazaki S, Yoshioka T, Ogawa Y, Sakayauchi T, Jingu K, Miyata G, Onodera K, Ichikawa H, Kamei T, Kato S, Ishioka C, Satomi S, Yamada S
- Journal Title
  
  Int J Radiat Oncol Biol Phys
  
  Volume: 75 Pages: 348-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009
- Author(s)
  Shibata, H., Yamakoshi, H., Sato, A., Ohori, H., Kakudo, Y., Kudo, C., Takahashi, Y., Watanabe, M., Takano, H., Ishioka, C., Noda, T., Iwabuchi, Y
- Journal Title
  
  Cancer Sci 100
  
  Pages: 956-60
- NAID
  10025146044
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Phase I/II study of sequential therapy with irinotecan and S-1 for metastatic colorectal cancer2009
- Author(s)
  Yoshioka T, Kato S, Gamoh M, Chiba N, Suzuki T, Sakayori N, Kato S, Shibata H, Shimodaira H, Otsuka K, Kakudo Y, Takahashi S, Ishioka C
- Journal Title
  
  Br J Cancer
  
  Volume: 101 Pages: 1972-7
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Determination of splice-site mutations in Lynch syndrome (hereditary non-polyposis colorectal cancer) patients using functional splicing assay2009
- Author(s)
  Naruse, H., Ikawa, N., Yamaguchi, K., Nakamura, Y., Arai, M., Ishioka, C., Sugano, K., Tamura, K., Tomita, N., Matsubara, N., Yoshida, T., Moriya, Y., Furukawa, Y
- Journal Title
  
  Fam Cancer 8
  
  Pages: 509-517
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Newly synthesized cur cumin analog has improved potential to prevent colorectal carcinogenesis in vivo2009
- Author(s)
  Shibata, H., Yamakoshi, H., Sato, A., Ohori, H., Kakudo, Y., Kudo, C., Takahashi, Y., Watanabe, M. , Takano, H. , Ishioka, C. , Noda, T. , Iwabuchi, Y
- Journal Title
  
  Cancer Sci
  
  Volume: 100 Pages: 956-60
- NAID
  10025146044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Analysis of p53 mutation status in human cancer cell lines: a paradigm for cell line cross-contamination2008
- Author(s)
  Berglind, H., Pawitan, Y., Kato, S., Ishioka, C., Soussi, T
- Journal Title
  
  Cancer Biol Ther 7
  
  Pages: 699-708
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Analysis of p53 mutation status in human cancer cell lines : a paradigm for cell line cross-contamination2008
- Author(s)
  Berglind, H., Pawitan, Y., Kato, S., Ishioka, C., Soussi, T
- Journal Title
  
  Cancer Biol Ther
  
  Volume: 7 Pages: 699-708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Prediction of breast cancer prognosis by gene expression profile of TP53 status2008
- Author(s)
  Takahashi, S., Moriya, T., Ishida, T., Shibata, H., Sasano, H., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci
  
  Volume: 99 Pages: 324-32
- NAID
  10024002457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku802008
- Author(s)
  Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C., Chiba, N
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 7380-93
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Prediction of breast cancer prognosis by gene expression profile of TP53 status2008
- Author(s)
  Takahashi, S., Moriya, T., Ishida, T., Shibata, H., Sasano, H., Ohuchi, N., Ishioka, C
- Journal Title
  
  Cancer Sci 99
  
  Pages: 324-32
- NAID
  10024002457
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku802008
- Author(s)
  Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C., Chiba, N
- Journal Title
  
  Mol Cell Biol
  
  Volume: 28 Pages: 7380-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390163
[Journal Article] The screening of the second-site suppressor mutations of the common p53 mutants2007
- Author(s)
  Otsuka, K., Kato, S., Kakudo, Y., Mashiko, S., Shibata, H., Ishioka, C
- Journal Title
  
  Int J Cancer 121
  
  Pages: 559-66
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Alpha-catenin is essential in intestinal adenoma formation2007
- Author(s)
  Shibata, H., Takano, H., Ito, M., Shioya, H., Hirota, M., Matsumoto, H., Kakudo, Y., Ishioka, C., Akiyama, T., Kanegae, Y., Saito, I., Noda, T
- Journal Title
  
  Proc Natl Acad Sci U S A 104
  
  Pages: 18199-204
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database2007
- Author(s)
  Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S.V., Hainaut, P., Olivier, M
- Journal Title
  
  Hum Mutat 28
  
  Pages: 622-9
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Functional analysis of human MLH1 variants using yeast and in vitro mismatch repair assays2007
- Author(s)
  Takahashi, M., Shimodaira, H., Andreutti-Zaugg, C., Iggo, R., Kolodner, R.D., Ishioka, C
- Journal Title
  
  Cancer Res 67
  
  Pages: 4595-604
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Predicting the Transactivation Activity of p53 Missense Mutants Using a Four-Body Potential Score Derived From Delaunay Tessellations2006
- Author(s)
  Mathe, E., Olivier, M., Kato, S., Ishioka, C., Vaisman, I., Hainaut, P
- Journal Title
  
  Hum Mutat 27
  
  Pages: 163-172
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods2006
- Author(s)
  Mathe, E., Olivier, M., Kato, S., Ishioka, C., Hainaut, P., Tavtigian, S. V
- Journal Title
  
  Nucleic Acids Res 34
  
  Pages: 1317-25
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection2006
- Author(s)
  Soussi, T., Asselain, B., Hamroun, D., Kato, S., Ishioka, C., Claustres, M., Beroud, C
- Journal Title
  
  Clin Cancer Res 12
  
  Pages: 62-69
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] MUT-TP53: a versatile matrix for TP53 mutation verification and publication2006
- Author(s)
  Soussi, T., Rubio-Nevado, J.M., Ishioka, C
- Journal Title
  
  Hum Mutat 27
  
  Pages: 1151-1154
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] The UMD TP53 database and website: update and revisions2006
- Author(s)
  Hamroun, D., Kato, S., Ishioka, C., Claustres, M., Beroud, C., Soussi, T
- Journal Title
  
  Hum Mutat 27
  
  Pages: 14-20
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] The Clinical Value of Somatic TP53 Gene Mutations in 1, 794 Patients with Breast Cancer2006
- Author(s)
  Olivier, M., Langerod, A., Carrieri, P., (other authors), Kato, S., Ishioka, C., Hainaut, P., Borresen-Dale, A
- Journal Title
  
  Clin Cancer Res 12
  
  Pages: 1157-1167
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Locus-specific mutation databases: pitfalls and good practice based on the p53 experience2006
- Author(s)
  Soussi, T., Ishioka, C., Claustres, M., Beroud, C
- Journal Title
  
  Nat Rev Cancer 6
  
  Pages: 83-90
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer2006
- Author(s)
  Ohori, H., Yamakoshi, H., Tomizawa, M., Shibuya, M., Kakudo, Y., Takahashi, A., Takahashi, S., Kato, S., Suzuki, T., Ishioka, C., Iwabuchi, Y., Shibata, H
- Journal Title
  
  Mol Cancer Ther 2006 5
  
  Pages: 2563-2571
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study2006
- Author(s)
  Iacopetta, B., Russo, A., Bazan, V., (other authors), Kato, S., Ishioka, C
- Journal Title
  
  Ann Oncol 17
  
  Pages: 842-847
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s2005
- Author(s)
  Kakudo, Y., Shibata, H., Otsuka, K., Kato, S., Ishioka, C
- Journal Title
  
  Cancer Res 65
  
  Pages: 2108-14
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] The relationship among p53 oligomer formation, structure and transcriptional activity using a comprehensive missense mutation library2005
- Author(s)
  Kawaguchi, T., Kato, S., Otsuka, K., Watanabe, G., Kumabe, T., Tominaga, T., Yoshimoto, T., Ishioka, C
- Journal Title
  
  Oncogene 24
  
  Pages: 6976-81
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations2005
- Author(s)
  Soussi, T., Kato, S., Levy, P.P., Ishioka, C
- Journal Title
  
  Hum Mutat 25
  
  Pages: 6-17
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II2005
- Author(s)
  Starita, L.M., Horwitz, A.A., Keogh, M.C., Ishioka, C., Parvin, J.D., Chiba, N
- Journal Title
  
  J Biol Chem 280
  
  Pages: 24498-505
- Data Source
  KAKENHI-PROJECT-17015002
[Patent] Novel phosphatidylinositol-3-kinase inhibitor and pharmaceutical composition2014
- Inventor(s)
  西條憲、石岡千加史、加藤正
- Industrial Property Rights Holder
  東北大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-05-27
- Overseas
- Data Source
  KAKENHI-PROJECT-24300339
[Patent] 新規ホスファチジルイノシトール3キナーゼ阻害剤及び医薬組成物2012
- Inventor(s)
  西條憲, 石岡千加史, 加藤正
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2012-09-25
- Overseas
- Data Source
  KAKENHI-PROJECT-24300339
[Patent] がんの予後予測方法2009
- Inventor(s)
  石岡千加史、高橋信
- Industrial Property Rights Holder
  東北大学
- Acquisition Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-17015002
[Patent] がんの予後予測方法2009
- Inventor(s)
  石岡千加史、高橋信
- Industrial Property Rights Holder
  東北大学
- Acquisition Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-20390163
[Patent] がんの予後予測方法2009
- Inventor(s)
  石岡千加史、高橋信
- Industrial Property Rights Holder
  東北大学
- Filing Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-17015002
[Patent] がんの予後予測方法2005
- Inventor(s)
  石岡千加史, 高橋信
- Industrial Property Rights Holder
  東北大学
- Industrial Property Number
  2005-181388
- Filing Date
  2005-06-22
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] The functional roles of miRNA-193a-3p in colorectal cancer.2021
- Author(s)
  Hiraide S, Takahashi M, Yoshida Y, Komine K, Ishioka C.
- Organizer
  AACR Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] The Advanced Research Center for Innovations in Next-Generation Medicine(INGEM) and personalised medicine．2020
- Author(s)
  Ishioka C
- Organizer
  UK-Japan Symposium on Data-Driven Health: Data strategies to predict risk, prevent and manage disease in individuals and populations.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] 高メチル化大腸がんが抗EGFR抗体薬抵抗性となる分子生物学的メカニズムの探索2020
- Author(s)
  大内康太，高橋信，沖田啓，大槻泰史，石岡千加史
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Development of an in vitro diagnostic test to predict the clinical outcome of anti-EGFR treatment based on DNA methylation status.2020
- Author(s)
  Ouchi K，Takahashi S，Ishioka C
- Organizer
  7th US-Japan Workshop on Biomarkers for Cancer Early Detection.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Analysis of consensus molecular subtypes (CMS) classification in the TRICOLORE trial: A randomized phase 3 trial of S-1 and irinotecan plus bevacizumab versus mFOLFOX6 or CapeOX plus bevacizumab as first-line treatment for metastatic colorectal cancer．2020
- Author(s)
  1.Yuki S，Gamoh M，Denda T，Takashima A，Takahashi S，Nakamura M，Ohori H，Yamaguchi T，Kobayashi Y，Baba H，Kotake M，Amagi K，Kondo H，Shimada K，Sato A，Ishioka C，Komine K，Ouchi K，Morita S，Komatu Y
- Organizer
  ASCO 2020 Gastrointestinal Cancers Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] Development of novel in vitro diagnostics to predict the efficacy of anti-EGFR treatment based on DNA methylation status．2019
- Author(s)
  4.大内康太，高橋信，沖田啓，坂本康寛，武藤理，天貝賢二，岡田恭穂，大堀久詔，篠崎英司，蒲生真紀夫，石岡千加史
- Organizer
  第 17 回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03508
[Presentation] The consensus molecular subtypes of colorectal cancer as a predictive factor for chemotherapies against metastatic colorectal cancer．2018
- Author(s)
  Okita, A.，Takahashi, S.，Ouchi, K.，Inoue, M.，Yamada, Y.，Ishioka, C
- Organizer
  2018 Gastrointestinal Cancers Symposium，
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] Consensus molecular subtypes（CMS）に基づく、進行・再発大腸癌に対する最適な化学療法の検討2017
- Author(s)
  沖田啓，高橋信，大内康太，山田英晴，笠原佑記，近松園子，高橋秀和，高橋雅信，下平秀樹，石岡千加史
- Organizer
  第15回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] 進行大腸癌の新しい分子標的薬とバイオマーカーの開発．2017
- Author(s)
  石岡千加史，西條憲，高橋信，大内康太，今井源，高橋雅信
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] 大腸がんに対する抗EGFR抗体薬の効果を予測する新規バイオマーカー・DNAメチル化状態診断キットの開発．2017
- Author(s)
  石岡千加史，高橋信，大内康太，高橋雅信，永江玄太
- Organizer
  ジャパン・キャンサーリサーチ・プロジェクト　平成28年度企業向け成果発表会
- Place of Presentation
  アキバホール（東京都・秋葉原）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] ヒト軟部肉腫細胞に対するHDAC/PI3K二重阻害剤としてのデプシペプチド類化合物の抗腫瘍効果の検討2016
- Author(s)
  西條憲，成田紘一，加藤正，石岡千加史
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター（大分県・別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] microRAN-193a-3p acts as a tumor suppressor in BRAF-mutated colorectal cancer．2016
- Author(s)
  Takahashi, H.，Takahashi, M.，Takahashi, S.，H., S.，Ishioka, C.
- Organizer
  AACR 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] デプシペプチド類縁体のPI3K阻害剤としての特性に関する検討2015
- Author(s)
  西條憲，成田紘一，下平秀樹，加藤正，石岡千加史
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] In vivo antitumor activity of FK-A11, a depsipeptide analog targeting both histone deacetylase and phosphoinositide 3-kinase2015
- Author(s)
  Saijo, K.，Narita, K.，Katoh, T.，Ishioka, C.
- Organizer
  ESMO Asia 2015
- Place of Presentation
  Singapore
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] デプシペプチド類縁体のPI3K阻害活性についての検討2015
- Author(s)
  西條憲，成田紘一，下平秀樹，加藤正，石岡千加史
- Organizer
  日本がん分子標的治療学会第19回学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15H04307
[Presentation] 新規HDAC/PI3K 2重阻害剤としてのデプシペプチド類縁体の抗腫瘍活性の検討2014
- Author(s)
  西條憲，李仁，成田紘一，加藤正，下平秀樹，石岡千加史
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] In vitroおよびin vivoにおけるPI3K/HDAC 2重阻害剤としてのFK228類縁体の抗腫瘍効果の評価2014
- Author(s)
  李仁，西條憲，下平秀樹，成田紘一，加藤正，石岡千加史
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] 457. HDAC/PI3K dual inhibitorとしてのRomidepsin(FK228)新規類縁体の開発と最適化2013
- Author(s)
  李仁, 西條憲, 下平秀樹, 成田紘一, 加藤正, 石岡千加史
- Organizer
  第17回日本がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300339
[Presentation] High throughput RNAi screening of synthetic lethal genes interacting with the common TP53 mutation R175H2012
- Author(s)
  Imai, H.,Kato, S.,Sakamoto, Y.,Takahashi, S.,Kakudo Y.,Shimodaira H.,Ishioka C.
- Organizer
  The 103rd Annual Meeting of American Association of Cancer Research
- Place of Presentation
  Chicago, IL, U.S.A.
- Year and Date
  2012-04-02
- Data Source
  KAKENHI-PROJECT-24650642
[Presentation] A randomized pilot study comparing safety and efficacy of irinotecan plus S-1 (IRIS)plus bevacizumab (BV)and modified (m)FOLFIRI plus BV in patients (pts)with metastatic colorectal cancer (marc): First report of T-CORE07022011
- Author(s)
  Kato, S. , Andoh, H. , Gamoh, M. , Yamaguchi, T. , Murakawa, Y. , Sasaki, Y. , Takahashi, S. , Shimodaira, H. , Yoshioka, T. , Ishioka, C.
- Organizer
  2011 Gastrointestinal Cancers Symposium
- Place of Presentation
  Florida・Orland world Center Marriott.General Poster Session C
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] Phase II trial of cetuximab plus irinotecan for FOLFOX and FOLFIRI-refractory patients with EGFR-positive advanced and/or metastatic colorectal cancer : Evaluation of the efficacy and safety based on KRAS mutation status (T-CORE0801)2011
- Author(s)
  Shimodaira, H. , Soeda, H. , Gamoh, M. , Andoh, H. , Yamaguchi, T. , Watanabe, M. , Isobe, H. , Sudo, T. , Kato, S. , Ishioka, C.
- Organizer
  2011 Gastrointestinal Cancers Symposium
- Place of Presentation
  Florida・Orland world Center Marriott.General Poster Session C
- Year and Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] Cytoplasmically localized wild-type p53 and S121F super p53 still retains apoptosis inducible abilities2009
- Author(s)
  Yasuda, K., Kato, S., Sakamoto, Y., Watanabe, G., Kakudo, Y., Ishioka, C.
- Organizer
  2009 AACR Annual Meeting
- Place of Presentation
  Denver Colorado USA(Poster)
- Year and Date
  2009-04-19
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 大腸癌治療の分子マーカー2009
- Author(s)
  石岡千加史
- Organizer
  宮城大腸癌セミナー
- Place of Presentation
  仙台ホテルモントレ(仙台市)
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Cytoplasmically localized wild-type p53 and S121F super p53 still retains apoptosis inducible abilities2009
- Author(s)
  Yasuda, K. , Kato, S. , Sakamoto, Y. , Watanabe, G. , Kakudo, Y. , Ishioka, C
- Organizer
  2009 AACR Annual Meeting
- Place of Presentation
  Denver Colorado USA.Poster
- Year and Date
  2009-04-19
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] 固形がんの治療と分子マーカー2009
- Author(s)
  石岡千加史
- Organizer
  第3回医学研究セミナー
- Place of Presentation
  金沢医科大学(金沢市)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 大腸癌治療の分子マーカー2009
- Author(s)
  石岡千加史
- Organizer
  宮城大腸癌セミナー
- Place of Presentation
  仙台ホテルモントレ(仙台市)
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] がんの診断・治療と疾患オミックス2009
- Author(s)
  石岡千加史
- Organizer
  第12回シンポジウムゲノム創薬フォーラム
- Place of Presentation
  日本薬学会館長井記念ホール(東京都)
- Year and Date
  2009-11-09
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] がん薬物療法と分子マーカー2009
- Author(s)
  石岡千加史
- Organizer
  第1回北海道臨床腫瘍研究会
- Place of Presentation
  札幌グランドホテル(札幌市)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 仮説に基づくマーカーと仮説に基づかないマーカー2009
- Author(s)
  石岡千加史
- Organizer
  第47回日本癌治療学会総会シンポジウム20日本癌学会、日本癌治療学会、日本臨床腫瘍学会合同シンポジウム「がんのバイオマーカーと分子標的薬」
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] がん薬物療法と分子マーカー2009
- Author(s)
  石岡千加史
- Organizer
  第1回北海道臨床腫瘍研究会
- Place of Presentation
  札幌グランドホテル(旭川市)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] 大腸癌薬物療法の進歩、日本の標準と国際標準の違いと将来2008
- Author(s)
  Ishioka, C
- Organizer
  中日胃腸腫瘍総合治療学術シンポジウム
- Place of Presentation
  北京・中日友好病院臨床研究所講学庁
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 大腸癌薬物療法の進歩2008
- Author(s)
  Ishioka, C
- Organizer
  日本の標準と国際標準の違いと将来
- Place of Presentation
  北京・中日友好病院臨床研究所講学庁. 招聘講演
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-20390163
[Presentation] Two cases of breast cancer responding to trastuzumab monotherapy.. Asia Pacific Medical Education Initiative2007
- Author(s)
  Chiba, N., Yoshioka, T., Takahashi, S., Shibata, H., Kato, S., Shimodaira, H., Otsuka, K., Kakudo, Y., Takahashi, M., Yasuda, K., Sakamoto, Y., Ishioka, C
- Organizer
  3rd Asia Pacific Workshop, Molecular targeted Therapy of Cancer
- Place of Presentation
  Shanghai China
- Year and Date
  2007-03-10
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Functional evaluation of genetic variants in hereditary colon cancer predispose genes2007
- Author(s)
  Shimodaira, H., Takahashi, M., Ishioka, C
- Organizer
  The 66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama・Pacifico-Yokohama(International Sesseions)
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Domain-dependent accumulation of BRCA1 at the sites of DNA damage2007
- Author(s)
  Chiba, N., Ishioka, C
- Organizer
  AACR-NCI-EORTC International conference Molecular targets and Cancer Therapeutics
- Place of Presentation
  San Francisco・U.S. A(poster)
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] αB crystallin is a novel p53-target gene and required for p53-dependent apoposis2007
- Author(s)
  Watanabe, G., Kato, S., Ishioka, C
- Organizer
  The 98th American Association for Cancer Research Annual Meeting
- Place of Presentation
  Los Angeles USA(Minisymposium)
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Evaluation of prognostic significance of TP53 expression signature in breast cancer2006
- Author(s)
  Ishioka, C., Shibata, H., Takahashi, S
- Organizer
  The 11th International Congress of Metastasis Research Society Jointed with the 15th Annual Meetng of Japanese Association for Metastasis Research (Plenary Sessions)
- Place of Presentation
  Tokushima Japan
- Year and Date
  2006-09-06
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Interaction site of the mismatch repair protein PMS2 with the proapoptotic protein p732006
- Author(s)
  Shimodaira, H., Takahashi, M., Ishioka, C
- Organizer
  The 97th American Association for Cancer Research Annual Meeting
- Place of Presentation
  Washington, DC., USA(poster)
- Year and Date
  2006-04-04
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Expression signature of p53 status (p53 signature) for the prediction of TP53 mutation and prognosis in breast cancer2006
- Author(s)
  Ishioka, C., Takahashi, S
- Organizer
  42nd American Society of Clinical Oncology Annual Meeting
- Place of Presentation
  Atlanta, GA(poster)
- Year and Date
  2006-06-03
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Functional characterization of hMLH1 missense mutations using yeast and in vitro assays2006
- Author(s)
  Takahashi, M., Shimodaira, H., Ishioka, C
- Organizer
  11th International Congress of Human Genetics
- Place of Presentation
  Brisbane, Australia(poster session)
- Year and Date
  2006-08-09
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Functional analysis of hMLH1 mutations using yeast and in vitro mismatch repair assays2006
- Author(s)
  Takahashi, M., Shimodaira, H., Kanamaru, R., Ishioka, C
- Organizer
  The 97th American Association for Cancer Research Annual Meeting
- Place of Presentation
  Washington, DC., USA(poster)
- Year and Date
  2006-04-03
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Analysis of relationship between p53-dependent transcriptional activity and its ability to induce apoptosis2005
- Author(s)
  Kakudo, Y., Shibata, H., Otsuka, K., Kato, S., Ishioka, C
- Organizer
  The 96th American Association for Cancer Research Annual Meeting
- Place of Presentation
  Anaheim U.S. A(Poster Session)
- Year and Date
  2005-04-19
- Data Source
  KAKENHI-PROJECT-17015002

1. SHIBATA Hiroyuki (50260071)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
2. KATO Shunsuke (40312657)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
3. KANAMARU Ryunosuke (70152783)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TAKAHASHI Masanobu (00447161)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
5. TAKAHASHI Shin (20431570)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
6. CHIBA Natuko (50361192)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. SAKAYORI Masato (20344666)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SAIJO Ken (70636729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
9. SHIBATA Shinobu (00271932)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SUZUKI Takao (90292276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 大内康太 (50781291)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
12. SHIMODAIRA Hideki (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
13. KATO Tadashi (50382669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. SASAKI Takeshi (50110656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KATO Shunsuke (60333887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIYASHITA MITSUNORI (90301142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高橋裕一 (80261535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 笠井均 (30312680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 雲林院宏 (40519352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 根本知己 (50291084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小関良卓 (80780634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. LI Jin

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. IMAI Hiroo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. FRIEND Stephen H

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. KOLODNER Richard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YOKOYAMA Yasunobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OKITA Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. KOBAYASHI Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 森田良治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. TAKAHASHI Hidekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 角道祐一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishioka Chikashi 石岡 千加史

ISHIOKA Chikashi 石岡 千加史

Research Projects

Research Products

Co-Researchers

がん細胞特有の刺激に応答し薬物を放出する新規抗がん薬ナノ粒子の開発

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Research on pathogenesis of DNA-highly methylated type colorectal cancer and the development of diagnosis and treatment methodsPrincipal Investigator

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End-of-life discussion between advanced cancer patients and physicians.

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Study on anti-EGFR antibody-resistant conquest of high DNA methylation type colorectal cancerPrincipal Investigator

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A search and optimization of the novel cancer molecules target drugs with PI3K/HDAC dual inhibitionPrincipal Investigator

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Search of mutant p53-specific target of cancer cellsPrincipal Investigator

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Screening molecular markers for prediction of recurrence and prognosis of colorectal cancer.Principal Investigator

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Development of functional assays for tumor-related genesPrincipal Investigator

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臨床応用に向けたクロマチン免疫沈降PCR法を用いたp53機能解析法の開発

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Development of p53-associated molecular devices for diagnosis and treatment of gastrointestinal cancerPrincipal Investigator

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Changing of the promater selectivity by p53 point nutations

Principal Investigator

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がん関連遺伝子変異の検出および機能評価法の開発Principal Investigator

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腫瘍関連遺伝子における遺伝子変異の機能評価Principal Investigator

Principal Investigator

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Ishioka Chikashi 石岡千加史

ISHIOKA Chikashi 石岡千加史

[Book] がん分子標的治療薬開発におけるProof of concept日本がん分子標的治療学会, 曽根三郎, 鶴尾隆編がん分子標的治療研究実践マニュアル2009

[Book] 入門腫瘍内科学(編集委員), 秋田弘俊, 石岡千加史, 田村和夫, 中川和彦, 原田実根, 南博信編入門腫瘍内科学(直腸, 結腸癌)2009

[Book] 4. がん薬物療法の分子標的4)アポトーシス西條長宏編癌治療の新たな試み新編III2005