tadokoro yuko 田所優子

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TADOKORO Yuko 田所優子

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Researcher Number	00447343
Other IDs
Affiliation (Current)	2025: 金沢大学, がん進展制御研究所, 助教
Affiliation (based on the past Project Information) *help	2025: 金沢大学, がん進展制御研究所, 助教 2011 – 2023: 金沢大学, がん進展制御研究所, 助教 2007 – 2010: Kanazawa University, がん研究所, 助教
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Transformative Research Areas, Section (III) / Dermatology Except Principal Investigator Hematology / Dermatology
Keywords	Principal Investigator 幹細胞 / 造血幹細胞 / ニッチ / 自己複製 / 加齢 / 細胞競合 / 老化 / アクチン / カロリー制限 / 細胞内ATP … More / がん / 幹細胞ニッチ / 白血病幹細胞 / 色素 / 皮膚 / 分化 / 発生 / 再生 … More Except Principal Investigator 幹細胞クローン / 造血幹細胞 / 加齢 / 毛包 / 色素細胞 / 分化 / 白髪 / 老化 / 色素幹細胞 / 幹細胞 Less

造血幹細胞の不均一性による造血加齢変容進展メカニズムの解明Principal Investigator
- Principal Investigator
  
  田所優子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
加齢に伴う造血幹細胞ニッチ変容の解明Principal Investigator
- Principal Investigator
  
  田所優子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
造血の加齢変化における幹細胞競合パラドックスの解明Principal Investigator
- Principal Investigator
  
  田所優子
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kanazawa University
Study of the regulatory mechanisms of hematopoietic stem cell homeostasis mediated by alterations in the nutritional environmentPrincipal Investigator
- Principal Investigator
  
  TADOKORO Yuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa University
Study of the regulation of hematopoietic stem cell self-renewal mediated by the control of actin polymerizationPrincipal Investigator
- Principal Investigator
  
  TADOKORO Yuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Regulation of hematopoietic stem cell function by calorie restrictionPrincipal Investigator
- Principal Investigator
  
  Tadokoro Yuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Mechanisms of expansion of hematopoietic stem cell clones
- Principal Investigator
  
  HIRAO Atsushi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Regulations of hematopoietic stem cell system by the control ofintracellular ATPPrincipal Investigator
- Principal Investigator
  
  TADOKORO Yuko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Analysis of hematopoietic stem cell and leukemic stem cell niche by focusing on Spred-1 functionsPrincipal Investigator
- Principal Investigator
  
  TADOKORO Yuko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
色素幹細胞の質的変化に着目した白髪の発症機序の解明
- Principal Investigator
  
  西村栄美
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Analysis of functions of Spred-1 in melanocyte stem cells and common molecular mechanisms in tissue-specific stem cell regulations.Principal Investigator
- Principal Investigator
  
  TADOKORO Yuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University

[Book] 別冊・医学の歩み、治療標的としてのがん幹細胞、Spred1による造血幹細胞制御と白血病化2021
- Author(s)
  田所　優子、平尾　敦
- Total Pages
  127
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K08860
[Book] 週刊　医学の歩み、治療標的としてのがん幹細胞、Spred1による造血幹細胞制御と白血病化2020
- Author(s)
  田所　優子、平尾　敦
- Total Pages
  479
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19K08860
[Book] 臨床血液2018
- Author(s)
  田所優子, 平尾敦
- Publisher
  日本血液学会
- Data Source
  KAKENHI-PROJECT-16K09824
[Book] 実験医学2018
- Author(s)
  田所優子, 平尾敦
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16K09824
[Book] 血液内科2018
- Author(s)
  田所優子, 平尾敦
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16K09824
[Book] 再生医療 "組織幹細胞システムにおける幹細胞ニッチ"2011
- Author(s)
  田所優子, 平尾敦
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23791076
[Book] 再生医療　"組織幹細胞システムにおける幹細胞ニッチ"2011
- Author(s)
  田所優子
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-23791076
[Book] 幹細胞研究の最近の進歩(後篇)組織幹細胞2009
- Author(s)
  田所優子
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-21790910
[Book] 幹細胞研究の最近の進歩(後篇)組織幹細胞「毛包における幹細胞とそのニッチ」2009
- Author(s)
  田所優子, 西村栄美
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-21790910
[Journal Article] Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation2023
- Author(s)
  Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A.
- Journal Title
  
  Cell Death Disease
  
  Volume: 14 Issue: 9 Pages: 642-642
- DOI
  10.1038/s41419-023-06168-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18298, KAKENHI-PROJECT-23K14729, KAKENHI-PROJECT-21K08396, KAKENHI-PROJECT-22K06896, KAKENHI-PROJECT-22K08448, KAKENHI-PROJECT-23K06629, KAKENHI-PROJECT-23K06672, KAKENHI-PROJECT-23K07855, KAKENHI-PUBLICLY-22H05622, KAKENHI-PROJECT-23K27437, KAKENHI-PROJECT-23K27624
[Journal Article] Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma2022
- Author(s)
  Jing Yongwei、Kobayashi Masahiko、Vu Ha Thi、Kasahara Atsuko、Chen Xi、Pham Loc Thi、Kurayoshi Kenta、Tadokoro Yuko、Ueno Masaya、Todo Tomoki、Nakada Mitsutoshi、Hirao Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 8 Pages: 2716-2726
- DOI
  10.1111/cas.15451
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08448, KAKENHI-PUBLICLY-22H05622, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-22H00483, KAKENHI-PROJECT-20K07565, KAKENHI-PROJECT-20K07566, KAKENHI-PROJECT-21K19502, KAKENHI-PROJECT-21K16264
[Journal Article] The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life2022
- Author(s)
  Yuko Tadokoro and Atsushi Hirao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1574-1589
- DOI
  10.3390/ijms23031574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08860, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-21K19502
[Journal Article] RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia2022
- Author(s)
  Pham Loc Thi、Peng Hui、Ueno Masaya、Kohno Susumu、Kasada Atuso、Hosomichi Kazuyoshi、Sato Takehiro、Kurayoshi Kenta、Kobayashi Masahiko、Tadokoro Yuko、Kasahara Atsuko、Shoulkamy Mahmoud I.、Xiao Bo、Worley Paul F.、Takahashi Chiaki、Tajima Atsushi、Hirao Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 621 Pages: 74-79
- DOI
  10.1016/j.bbrc.2022.06.089
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08448, KAKENHI-PUBLICLY-22H05622, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-19H01356, KAKENHI-PROJECT-20H03509, KAKENHI-PROJECT-20K07565, KAKENHI-PROJECT-20K07566, KAKENHI-PROJECT-20K07612, KAKENHI-PROJECT-21K19502, KAKENHI-PROJECT-21K16264, KAKENHI-PUBLICLY-21H00342
[Journal Article] Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner2021
- Author(s)
  Nomura Naho、Ito Chiaki、Ooshio Takako、Tadokoro Yuko、Kohno Susumu、Ueno Masaya、Kobayashi Masahiko、Kasahara Atsuko、Takase Yusuke、Kurayoshi Kenta、Si Sha、Takahashi Chiaki、Komatsu Masaaki、Yanagawa Toru、Hirao Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1666-1679
- DOI
  10.1038/s41598-021-81076-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06657, KAKENHI-PROJECT-19K08860, KAKENHI-PROJECT-20K07566, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-20H03509, KAKENHI-PROJECT-19K22555, KAKENHI-PROJECT-19K17824, KAKENHI-PROJECT-19H03846, KAKENHI-PROJECT-20K07565, KAKENHI-PROJECT-20K07612, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K07558
[Journal Article] Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples2020
- Author(s)
  Ueno Masaya、Tomita Takuya、Arakawa Hiroshi、Kakuta Takahiro、Yamagishi Tada-aki、Terakawa Jumpei、Daikoku Takiko、Horike Shin-ichi、Si Sha、Kurayoshi Kenta、Ito Chiaki、Kasahara Atsuko、Tadokoro Yuko、Kobayashi Masahiko、Fukuwatari Tsutomu、Tamai Ikumi、Hirao Atsushi、Ogoshi Tomoki
- Journal Title
  
  Communications Chemistry
  
  Volume: 3 Issue: 1 Pages: 1-10
- DOI
  10.1038/s42004-020-00430-w
- NAID
  120006939157
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06657, KAKENHI-PROJECT-19K08860, KAKENHI-PROJECT-20K07565, KAKENHI-PROJECT-19H00909, KAKENHI-PROJECT-19H01033, KAKENHI-PROJECT-19K17824, KAKENHI-PROJECT-19K18691
[Journal Article] Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress2018
- Author(s)
  Tadokoro Yuko、Hoshii Takayuki、Yamazaki Satoshi、Eto Koji、Ema Hideo、Kobayashi Masahiko、Ueno Masaya、Ohta Kumiko、Arai Yuriko、Hara Eiji、Harada Kenichi、Oshima Masanobu、Oshima Hiroko、Arai Fumio、Yoshimura Akihiko、Nakauchi Hiromitsu、Hirao Atsushi
- Journal Title
  
  Cell Stem Cell
  
  Volume: 22 Issue: 5 Pages: 713-725
- DOI
  10.1016/j.stem.2018.04.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09919, KAKENHI-PUBLICLY-17H05638, KAKENHI-PUBLICLY-18H05095, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-17K19585, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04164
[Journal Article] Regulation of hematopoietic stem cell homeostasis by Spred12018
- Author(s)
  Yuko Tadokoro and Atsushi Hirao
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 59 Issue: 11 Pages: 2441-2448
- DOI
  10.11406/rinketsu.59.2441
- NAID
  130007528403
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09824
[Journal Article] Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells2018
- Author(s)
  Hui Peng, Atsuo Kasada, Masaya Ueno, Takayuki Hoshii, Yuko Tadokoro, Naho Nomura, Chiaki Ito, Yusuke Takase, Ha Thi Vu, Masahiko Kobayashi, Bo Xiao, Paul F. Worley, Atsushi Hirao
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 1129-1135
- DOI
  10.1016/j.bbrc.2017.11.140
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-17K07160, KAKENHI-PROJECT-17K09919, KAKENHI-PROJECT-17K19585, KAKENHI-PUBLICLY-16H01199, KAKENHI-PUBLICLY-17H05638, KAKENHI-PROJECT-15H02361
[Journal Article] Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.2018
- Author(s)
  Vu HT, Kobayashi M, Hegazy AM, Tadokoro Y, Ueno M, Kasahara A, Takase Y, Nomura N, Peng H, Ito C, Ino Y, Todo T, Nakada M, Hirao A
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 8 Pages: 2497-2508
- DOI
  10.1111/cas.13695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07160, KAKENHI-PROJECT-17K09919, KAKENHI-PUBLICLY-17H05638, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-17K19585, KAKENHI-PROJECT-17K17758, KAKENHI-PROJECT-16H06276
[Journal Article] Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression2017
- Author(s)
  Ali Mohamed A. E.、Fuse Kyoko、Tadokoro Yuko、Hoshii Takayuki、Ueno Masaya、Kobayashi Masahiko、Nomura Naho、Vu Ha Thi、Peng Hui、Hegazy Ahmed M.、Masuko Masayoshi、Sone Hirohito、Arai Fumio、Tajima Atsushi、Hirao Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 11442-11442
- DOI
  10.1038/s41598-017-11909-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09824, KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K09919, KAKENHI-PROJECT-17K19585, KAKENHI-PUBLICLY-16H01199, KAKENHI-PUBLICLY-17H05638, KAKENHI-PROJECT-15H02361, KAKENHI-PROJECT-17H04208
[Journal Article] Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.2014
- Author(s)
  Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 450 Issue: 1 Pages: 837-843
- DOI
  10.1016/j.bbrc.2014.06.066
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24240119, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25340028, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-26460361, KAKENHI-PROJECT-26640070
[Journal Article] Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals.2014
- Author(s)
  Yamada D, Hoshii T, Tanaka S, Hegazy AM, Kobayashi M, Tadokoro Y, Ohta K, Ueno M, Ali MAE, Hirao A.
- Journal Title
  
  J Biochem.
  
  Volume: 155 Issue: 4 Pages: 227-33
- DOI
  10.1093/jb/mvt112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25340028, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25861263, KAKENHI-PROJECT-26460361
[Journal Article] Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors2013
- Author(s)
  Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A.
- Journal Title
  
  Am. J. Pathol.
  
  Volume: 183 Issue: 2 Pages: 592-603
- DOI
  10.1016/j.ajpath.2013.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25293082, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25670147
[Journal Article] Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.2013
- Author(s)
  Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 111 Issue: 10 Pages: 3805-3810
- DOI
  10.1073/pnas.1320265111
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22118004, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24249057, KAKENHI-PROJECT-24689042, KAKENHI-PROJECT-24790967, KAKENHI-PUBLICLY-25118710, KAKENHI-PUBLICLY-25118732, KAKENHI-PUBLICLY-25130705, KAKENHI-PROJECT-25460602, KAKENHI-PROJECT-25461411, KAKENHI-PROJECT-25670236, KAKENHI-PROJECT-25670447, KAKENHI-PROJECT-221S0001
[Journal Article] mTORC1is essential for leukemia propagation but not stem cell self-renewal.2012
- Author(s)
  Hoshii. T
- Journal Title
  
  J Clin Invest.
  
  Volume: 122 Issue: 6 Pages: 2114-2129
- DOI
  10.1172/jci62279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06332, KAKENHI-PROJECT-22790906, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23791076, KAKENHI-PROJECT-24240119, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-22134007, KAKENHI-PUBLICLY-23118511, KAKENHI-PUBLICLY-23130507, KAKENHI-PUBLICLY-23134507, KAKENHI-PUBLICLY-24115712
[Journal Article] NKX2.2Suppresses Self-Renewal of Glioma-Initiating Cells.2011
- Author(s)
  Teruyuki Muraguchi, Shingo Tanaka, Daisuke Yamada, Akira Tamase, Mitsutoshi Nakada, Hideo Nakamura, Takayuki Hoshii, Takako Ooshio, Yuko Tadokoro, Kazuhito Naka, Yasushi Ino, Tomoki Todo, Jun-ichi Kuratsu, Hideyuki Saya, Jun-ichiro Hamada, Atsushi Hirao
- Journal Title
  
  Cancer Research 71(3)
  
  Pages: 1135-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790910
[Journal Article] Nishimura.Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells.2011
- Author(s)
  Shintaro Tanimura, Yuko Tadokoro(co-first author), Ken Inomata, Nguyen Thanh Binh, Wataru Nishie, Satoshi Yamazaki, Hiromitsu Nakauchi, Yoshio Tanaka, James R.McMillan, Daisuke Sawamura, Kim Yancey, Hiroshi Shimizu, Emi K.
- Journal Title
  
  Cell Stem Cell 8(2)
  
  Pages: 177-187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790910
[Journal Article] Molecular pathology of tumor-initiating cells : lessons from Philadelphia chromosome-positive leukemia2011
- Author(s)
  Naka K, Hoshii T, Tadokoro Y, Hirao A.
- Journal Title
  
  Pathol Int
  
  Volume: 61 Issue: 9 Pages: 501-8
- DOI
  10.1111/j.1440-1827.2011.02688.x
- NAID
  10031185122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390290, KAKENHI-PROJECT-22790906, KAKENHI-PUBLICLY-23118511, KAKENHI-PUBLICLY-23130507, KAKENHI-PROJECT-23650593, KAKENHI-PROJECT-23791076
[Journal Article] TGF-β.FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia.2010
- Author(s)
  Kazuhito Naka, Takayuki Hoshii, Teruyuki Muraguchi, Yuko Tadokoro, Takako Ooshio, Yukio Kondo, Shinji Nakao, Noboru Motoyama, Atsushi Hirao
- Journal Title
  
  Nature 463
  
  Pages: 676-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790910
[Journal Article] Structural and functional changes of sulfated glycosaminoglycans in Xenopus laevis during embryogenesis.2009
- Author(s)
  Shuhei Yamada, Masako Onishi, Reiko Fujinawa, Yuko Tadokoro, Koji Okabayashi, Makoto Asashima and Kazuyuki Sugahara
- Journal Title
  
  Glycobiology 19(5)
  
  Pages: 488-498
- NAID
  120002087034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790775
[Journal Article] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.2007
- Author(s)
  Yuko Tadokoro, Hideo Ema, Masaki Okano, En Li, and Hiromitsu Nakauchi
- Journal Title
  
  The Journal of Experimental Medicine 204(4)
  
  Pages: 715-722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790775
[Journal Article] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells2007
- Author(s)
  Yuko Tadokoro
- Journal Title
  
  The Journal of Experimental Medicine 204(4)
  
  Pages: 715-722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790775
[Patent] Methods for inhibiting hair depigmentation and hair loss2008
- Inventor(s)
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Industrial Property Rights Holder
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Filing Date
  2008-02-22
- Overseas
- Data Source
  KAKENHI-PROJECT-19790775
[Patent] Methods for inhibiting hair depigmentation and hair loss2008
- Inventor(s)
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Industrial Property Rights Holder
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Filing Date
  2008-02-22
- Overseas
- Data Source
  KAKENHI-PROJECT-19790775
[Patent] XVII型コラーゲンに関する分化抑制剤2007
- Inventor(s)
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Industrial Property Rights Holder
  西村栄美、清水宏、谷村心太郎、田所優子、澤村大輔、西江渉
- Industrial Property Number
  2007-202319
- Filing Date
  2007-08-02
- Data Source
  KAKENHI-PROJECT-19790775
[Presentation] 免疫調節による造血幹細胞エイジング制御機構の解明2024
- Author(s)
  田所優子、平尾敦
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PUBLICLY-22H05622
[Presentation] 造血幹細胞の恒常性維持機構の解明とその制御による健康寿命延伸を目指して2024
- Author(s)
  田所優子
- Organizer
  文部科学省共同利用・共同研究システム形成事業学際領域展開ハブ形成プログラムキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H05622
[Presentation] 造血幹細胞の恒常性維持機構の解明とその制御による健康寿命延伸を目指して2024
- Author(s)
  田所優子
- Organizer
  文部科学省共同利用・共同研究システム形成事業学際領域展開ハブ形成プログラムキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K08448
[Presentation] 免疫調節による造血幹細胞エイジング制御機構の解明2024
- Author(s)
  田所優子、平尾敦
- Organizer
  第28回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-22K08448
[Presentation] Regulation of hematopoietic stem cell aging by adaptive immunity2023
- Author(s)
  Yuko Tadokoro, Atsushi Hirao
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-22K08448
[Presentation] Regulation of hematopoietic stem cell aging by adaptive immunity2023
- Author(s)
  Yuko Tadokoro, Atsushi Hirao
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H05622
[Presentation] 加齢に伴う免疫変化による造血幹細胞エイジング進展機構2022
- Author(s)
  田所　優子、平尾　敦
- Organizer
  第32回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08448
[Presentation] 加齢に伴う免疫変化による造血幹細胞エイジング進展機構2022
- Author(s)
  田所　優子、平尾　敦
- Organizer
  第32回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PUBLICLY-22H05622
[Presentation] 造血器腫瘍制御に寄与する食物栄養依存性代謝物の探索2021
- Author(s)
  陳　茜、田所　優子、司　沙、本田　浩章、平尾　敦
- Organizer
  第25回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] 加齢に伴う造血の変化―造血幹細胞エイジングに着目して―2021
- Author(s)
  田所優子
- Organizer
  第43回日本生物学的精神医学会・第51回日本神経精神薬理学会　合同年会　BPNP2021 サテライトシンポジウム　B6J Aged研究会　第3回講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.2019
- Author(s)
  田所　優子
- Organizer
  第15回血液学若手研究者勉強会（麒麟塾）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] 腸内細菌由来代謝物による造血幹細胞の機能制御2019
- Author(s)
  田所　優子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] Regulation of hematopoietic stem cell fate by gut microbiota-derived metabolites2019
- Author(s)
  Yuko Tadokoro
- Organizer
  International symposium on tumor biology in Kanazawa 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] Regulation of hematopoietic stem cell fate by gut microbiota-derived metabolites2019
- Author(s)
  Yuko Tadokoro
- Organizer
  Joint Symposium on Tumor Microenvironment and Precision Oncology Between SNU-GCRC and KU-CRI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08860
[Presentation] Spred1 protects hematopoietic stem cell homeostasis against high fat diet-induced systemic stress2018
- Author(s)
  田所　優子
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] 栄養環境ストレスとSpred1による造血幹細胞の恒常性維持機構2018
- Author(s)
  田所　優子
- Organizer
  新学術領域「幹細胞老化と疾患」「細胞競合」総括班主催「若手の会」
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Spred1 protects hematopoietic homeostasis against high-fat diet-induced systemic stress2018
- Author(s)
  Yuko Tadokoro
- Organizer
  The 37th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] 造血幹細胞の自己複製制御機構と発がん2018
- Author(s)
  田所　優子
- Organizer
  第１回　金沢大学がん進展制御研究所・国立がん研究センター研究所若手研究発表会
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] 栄養環境ストレスと造血幹細胞の恒常性維持機構2018
- Author(s)
  田所　優子
- Organizer
  北海道大学遺伝子病制御研究所・金沢大学がん進展制御研究所ジョイントシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] 栄養環境ストレスとSpred1による造血幹細胞の恒常性維持機構2018
- Author(s)
  田所　優子
- Organizer
  第22回造血器腫瘍研究会
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Diet-induced stress and homeostasis maintenance in hematopoietic stem cells2018
- Author(s)
  Yuko Tadokoro
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Regulation of hematopoietic stem cell self-renewal and leukemogenesis by diet-induced stress2018
- Author(s)
  Yuko Tadokoro
- Organizer
  International Symposium on Tumor Biology in Kanazawa
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Spred1による造血幹細胞の恒常性維持機構と発がん2017
- Author(s)
  田所　優子
- Organizer
  金沢大学がん進展制御研究所　共同利用・共同研究拠点シンポジウム
- Place of Presentation
  金沢東急ホテル　（石川県）
- Year and Date
  2017-02-14
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Self-renewal control and tumorigenesis of hematopoietic stem cells by regulation of actin polymerization2016
- Author(s)
  Yuko Tadokoro
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川県）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] アクチン重合調節を介した幹細胞の自己複製制御機構と発がん2016
- Author(s)
  田所　優子
- Organizer
  金沢女性がん研究者フォーラム
- Place of Presentation
  金沢医科大学　（石川県）
- Year and Date
  2016-06-21
- Data Source
  KAKENHI-PROJECT-16K09824
[Presentation] Spred1 regulates the self-renewal activity of hematopoietic stem cells2015
- Author(s)
  Yuko Tadokoro, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（石川県）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Quality control of undifferentiated status in hematopoietic stem cells during cell division by Spred12015
- Author(s)
  Yuko Tadokoro, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  The 13th Stem Cell Research Symposium
- Place of Presentation
  東京大学　伊藤国際学術研究センター（東京）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Role of Spred1 in the regulation of self-renewal and aging of hematopoietic stem cells2015
- Author(s)
  Yuko Tadokoro, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  ISEH 44rd Annual Scientific Meeting
- Place of Presentation
  国立京都国際会館（京都府）
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Spred1 regulates the self-renewal activity in hematopoietic stem cells2015
- Author(s)
  Yuko Tadokoro, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  The 10th International Symposium of the Institute Network
- Place of Presentation
  北海道大学遺伝子病制御研究所（北海道）
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Spred-1 regulates the competitive advantage of hematopoietic stem cells in the bone marrow microenvironment2014
- Author(s)
  Yuko Tadokoro, Atsushi Hirao, Takayuki Hoshii, Kazuhito Naka, Koji Eto, Hideo Ema, Satoshi Yamazaki, Akihiko Yoshimura, Hiromitsu Nakauchi
- Organizer
  International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discovery in Academics
- Place of Presentation
  金沢エクセルホテル東急（石川県）
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] A competitive advantage ofhematopoietic stem cells in the bone marrow controlled by Spred-12012
- Author(s)
  Yuko Tadokoro
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] A competitive advantage of hematopoietic stem cells in the bone marrow controlled by Spred-12012
- Author(s)
  Yuko Tadokoro
- Organizer
  第74回　日本血液学会学術集会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] A competitive advantage ofhematopoietic stem cells in the bone marrow controlled by Spred-12012
- Author(s)
  Yuko Tadokoro
- Organizer
  The 10thStem Cell Research Symposium
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] A competitive advantage of hematopoietic stem cells in the bone marrow microenvironment controlled by Spred-12012
- Author(s)
  Yuko Tadokoro
- Organizer
  The 10th Stem Cell Research Symposium
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川県)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-1.2011
- Author(s)
  Yuko Tadokoro
- Organizer
  USA-Japan Cooperative Cancer Research Workshop
- Place of Presentation
  湘南国際村センター(神奈川県)
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-21790910
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  The 6th International Symposium of Institute Network
- Place of Presentation
  東京医科歯科大学（東京）
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  泉ガーデンギャラリー（東京）
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  The 9thStem Cell Research Symposium
- Place of Presentation
  泉ガーデンギャラリー(東京)
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  USA-Japan Cooperative Cancer Research Workshop
- Place of Presentation
  湘南国際村センター(神奈川県)
- Year and Date
  2011-02-26
- Data Source
  KAKENHI-PROJECT-21790910
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-12011
- Author(s)
  Yuko Tadokoro
- Organizer
  The 6thInternational Symposium of Institute Network
- Place of Presentation
  東京医科歯科大学(東京)
- Data Source
  KAKENHI-PROJECT-23791076
[Presentation] Inhibitory effect of Spred1 on self-renewal activity mediated by cell-cell interaction determines size of hematopoietic stem cell pool
- Author(s)
  Yuko Tadokoro, Takayuki Hoshii, Kazuhito Naka, Koji Eto, Hideo Ema, Satoshi Yamazaki, Akihiko Yoshimura, Hiromitsu Akauchi, Atsushi Hirao
- Organizer
  12th Stem Cell Research Symposium
- Place of Presentation
  九州大学百年講堂（福岡県）
- Year and Date
  2014-05-30 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Control of self-renewal activity of hematopoietic stem cells by Spred1
- Author(s)
  Yuko Tadokoro, Koji Eto, Hideo Ema, Satoshi Yamazaki, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム
- Place of Presentation
  石川県立音楽堂交流ホール（石川県）
- Year and Date
  2015-01-21 – 2015-01-22
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Control of self-renewal activity of hematopoietic stem cells by Spred1
- Author(s)
  Yuko Tadokoro, Koji Eto, Hideo Ema, Satoshi Yamazaki, Akihiko Yoshimura, Hiromitsu Nakauchi, Atsushi Hirao
- Organizer
  ISEH 43rd Annual Scientific Meeting
- Place of Presentation
  Montreal, Canada
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461411
[Presentation] Enhanced competitive repopulation ability of hematopoietic stem cells by inhibition of Spred-1
- Author(s)
  Yuko Tadokoro
- Organizer
  日本分子生物学会　第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂（石川県）
- Data Source
  KAKENHI-PROJECT-23791076
[]
[]

1. HIRAO Atsushi (90343350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 西村栄美 (70396331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 阿部理一郎 (60344511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 西村泰行 (30314181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 曽我朋義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 上野将也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 笠原敦子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 河本宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小林昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

tadokoro yuko 田所 優子

TADOKORO Yuko 田所 優子

Research Projects

Research Products

Co-Researchers

造血幹細胞の不均一性による造血加齢変容進展メカニズムの解明Principal Investigator

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加齢に伴う造血幹細胞ニッチ変容の解明Principal Investigator

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造血の加齢変化における幹細胞競合パラドックスの解明Principal Investigator

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Study of the regulatory mechanisms of hematopoietic stem cell homeostasis mediated by alterations in the nutritional environmentPrincipal Investigator

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Study of the regulation of hematopoietic stem cell self-renewal mediated by the control of actin polymerizationPrincipal Investigator

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Regulation of hematopoietic stem cell function by calorie restrictionPrincipal Investigator

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Mechanisms of expansion of hematopoietic stem cell clones

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Regulations of hematopoietic stem cell system by the control ofintracellular ATPPrincipal Investigator

Principal Investigator

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Analysis of hematopoietic stem cell and leukemic stem cell niche by focusing on Spred-1 functionsPrincipal Investigator

Principal Investigator

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色素幹細胞の質的変化に着目した白髪の発症機序の解明

Principal Investigator

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Analysis of functions of Spred-1 in melanocyte stem cells and common molecular mechanisms in tissue-specific stem cell regulations.Principal Investigator

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[Book] 別冊・医学の歩み、治療標的としてのがん幹細胞、Spred1による造血幹細胞制御と白血病化2021

Author(s)

Total Pages

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Data Source

[Book] 週刊 医学の歩み、治療標的としてのがん幹細胞、Spred1による造血幹細胞制御と白血病化2020

Author(s)

Total Pages

Publisher

tadokoro yuko 田所優子

TADOKORO Yuko 田所優子

[Book] 週刊　医学の歩み、治療標的としてのがん幹細胞、Spred1による造血幹細胞制御と白血病化2020

[Book] 再生医療　"組織幹細胞システムにおける幹細胞ニッチ"2011