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ISHII Ken  石井 健

… Alternative Names

Ishii Ken  石井 健

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Researcher Number 00448086
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6728-3872
Affiliation (Current) 2025: 東京大学, 医科学研究所, 教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 東京大学, 医科学研究所, 教授
2018 – 2019: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, 招へいプロジェクトリーダー
2017: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 ワクチン・アジュバント研究センター, センター長
2017: 国立研究開発法人医薬基盤研究所, 教授
2015 – 2016: 国立研究開発法人医薬基盤・健康・栄養研究所, 創薬基盤研究部, プロジェクトリーダー … More
2014: 独立行政法人・医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー
2011: 大阪大学, 免疫学フロンティア研究センター, 教授
2010 – 2011: 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー
2010: 医薬基盤研究所, プロジェクトリーダー
2007 – 2010: Osaka University, 微生物病研究所, 准教授 Less
Review Section/Research Field
Principal Investigator
Immunology
Except Principal Investigator
Basic Section 53010:Gastroenterology-related / Parasitology (including Sanitary zoology) / Emergency medicine / General internal medicine and related fields / Gastroenterology / Hygiene and public health / Bacteriology (including Mycology) / Biological Sciences
Keywords
Principal Investigator
自然免疫 / アジュバント / ワクチン / CpG / ベータ グルカン / 核酸 / TLR7 / シグナル伝達 / インフルエンザ / 抗原提示 / 樹状細胞 / TLR / DNA … More
Except Principal Investigator
… More ワクチン / 自然免疫 / がん免疫 / 膵癌 / 消化器がん / 遺伝子多型 / マラリア / 光免疫療法 / TLR9 / CpG / 細菌性肺炎 / 急性肺傷害 / Ⅲ型分泌システム / 経鼻ワクチン / アジュバント / 経鼻 / 前臨床試験 / 動物モデル / 肺炎 / CpG oligonucleotide / PcrV / 三型分泌システム / 緑膿菌 / アレルギー / TALT / 感作 / 目 / IgE / アレルギー性炎症 / 眼免疫 / 肝細胞癌 / 肝がん / 消化器癌 / トルコ共和国 / 自己炎症疾患 / 環境因子 / 家族性地中海熱 / トルコ / インフラマソーム / ディフェロキサミン / リポカリン2 / mammalian siderophore / 免疫学 / プラスモディウム・ヨエリ / 貧血 / 感染症 / 鉄代謝 / リポカン2 / 遺伝子組換え / 遺伝子組み換え / マイクロサテライト / 組み換え / 流行度 / 多重感染 / 三日熱マラリア原虫 / SPR / QCM / 融合タンパク / 分子間相互作用 / センサー / 病原体 / TLR / SE36 マラリアワクチン / 多重族遺伝子群 / SE36マラリアワクチン / 多重遺伝子群 / Plasmodium Less
  • Research Projects

    (12 results)
  • Research Products

    (87 results)
  • Co-Researchers

    (34 People)
  •  光免疫療法を組み込んだin situワクチンによる消化器がんの術前免疫療法の開発

    • Principal Investigator
      高橋 健
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Kyoto University
  •  Preclinical study of near-infrared photoimmunotherapy for pancreatic cancer that incorporates nanoparticulate TLR9 agonist K3-SPG

    • Principal Investigator
      Ken Takahashi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      The Tazuke Kofukai
      Kyoto University
  •  Preclinical study of in situ vaccine immunotherapy for hepatocellular carcinoma targeting TLR9 and RIG-I

    • Principal Investigator
      TAKAHASHI Ken
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kyoto University
  •  Analysis of allergic inflammation triggered by eyes.

    • Principal Investigator
      Kuroda Etsushi
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Preclinical study of Pseudomonas aeruginosa PcrV-CpG(K3)-SPG Vaccine

    • Principal Investigator
      Sawa Teiji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  A comparative study of intrinsic factor activating inflammasome between Turkey and Japan

    • Principal Investigator
      Masumoto Junya
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene and public health
    • Research Institution
      Ehime University
  •  Intra-and inter-cellular vaccine-induced signaling pathwaysPrincipal Investigator

    • Principal Investigator
      ISHII Ken
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      独立行政法人医薬基盤研究所
      Osaka University
  •  Role of Lipocalin 2 during malaria infection

    • Principal Investigator
      COBAN Cevayir
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      Osaka University
  •  How P.vivax parasite maintains multiple infection in areas of low intensity malaria?

    • Principal Investigator
      HORII Toshihiro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      Osaka University
  •  Mechanism of nucleic ac id-based vaccine immunogenicityPrincipal Investigator

    • Principal Investigator
      ISHII Ken
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Osaka University
  •  Malaria genetic diversity as a basis for parasite growth and pathogenicity

    • Principal Investigator
      HORII Toshihiro
    • Project Period (FY)
      2006 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  リコンビナントTLR融合蛋白を用いた病原体バイオセンサーの開発

    • Principal Investigator
      鈴木 幸一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      National Institute of Infectious Diseases

All 2023 2022 2018 2017 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] Extracellular nucleic acids : Immune recognition of nucleic acids and their metabolites2010

    • Author(s)
      Koyama S, Akira S, Ishii KJ
    • Total Pages
      250
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Book] Nucleic Acids in Innate Immun i ty2008

    • Author(s)
      Ken J. Ishii
    • Total Pages
      286
    • Publisher
      CRC press
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Book] Willey Publisher2008

    • Author(s)
      Ishii KJ, Koyama S and Akira S.
    • Publisher
      "Overview : Innate immune response to nucleic acids" Immune response to gene therapy(edited by Roland Herzog)
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Book] "Nucleic Acids in Innate Immunity" Editor in chief2008

    • Author(s)
      Ishii KJ and Akira S.
    • Publisher
      CRC press
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Book] Weyand, Frew2007

    • Author(s)
      Ishii KJ, Akira S.
    • Publisher
      "Innate Immunity" Clinical Immunology 3rd Ed.(Edited by Rich, Shearer, Fleisher, Schroeder)
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Book] Eurekah and Landes Bioscience2007

    • Author(s)
      Coban C, Ishii KJ, Akira S.
    • Publisher
      "Immune intervention of human diseases through Toll-like receptors" Pharmaceutical Biotechnology edited by Carlos A. Guzman and Giora Feuerstein
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy2022

    • Author(s)
      Okada H, Takahashi K, Yaku H, Kobiyama K, Iwaisako K, Zhao X, Shiokawa M, Uza N, Kodama Y, Ishii KJ, Seno H.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 2132-2132

    • DOI

      10.1038/s41598-022-05702-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03659, KAKENHI-PROJECT-20K08996, KAKENHI-PROJECT-21K20802, KAKENHI-PROJECT-20K08329
  • [Journal Article] Efficacy comparison of adjuvants in PcrV vaccine against Pseudomonas aeruginosa pneumonia.2017

    • Author(s)
      Hamaoka S, Niato Y, Katoh H, Shimizu M, Kinoshita M, Kainuma A, Akiyama K, Sawa T.
    • Journal Title

      Microbial Immunol

      Volume: 61 Issue: 2 Pages: 64-74

    • DOI

      10.1111/1348-0421.12467

    • NAID

      40021166122

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H05008, KAKENHI-PROJECT-17H07015, KAKENHI-PROJECT-26670791
  • [Journal Article] Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms2011

    • Author(s)
      Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y
    • Journal Title

      Immunity

      Volume: 34(4) Pages: 514-526

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] マラリアヘモゾインに対するTLR9での反応と免疫増強効果2011

    • Author(s)
      津久井利広、Coban, Cevayir, 八木正典、大畑敬一、猪狩義勝、福井真人、堀井俊宏、審良静男、石井健
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 55(1) Pages: 28-34

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax2011

    • Author(s)
      Yildiz Zeyrek F, Palacpac N, Yuksel F, Yagi M, Honjo K, Fujita Y, Arisue N, Takeo S, Tanabe K, Horii T, Tsuboi T, Ishii KJ, Coban C*
    • Journal Title

      PLoS ONE

      Volume: 6(11)

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Novel Strategies to Improve DNA Vaccine Immunogenicity2011

    • Author(s)
      Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ
    • Journal Title

      Review, Current Gene Therapy

      Volume: 11(6) Pages: 479-484

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] DNA released from dying host cells mediates aluminum adjuvant activity2011

    • Author(s)
      Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ
    • Journal Title

      Nature Medicine

      Volume: 17(8) Pages: 996-1002

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Novel Strategies to Improve DNA Vaccine Immunogenicity2011

    • Author(s)
      Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ
    • Journal Title

      Current Gene Therapy

      Volume: 11(6) Pages: 479-484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Innate and adaptive immune responses to viral infection and vaccination2011

    • Author(s)
      Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ
    • Journal Title

      Curr Opin Virol

      Volume: 1(4) Issue: 4 Pages: 226-32

    • DOI

      10.1016/j.coviro.2011.07.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390152, KAKENHI-PROJECT-22790461
  • [Journal Article] DNA released from dying host cells mediates aluminum adjuvant activity2011

    • Author(s)
      Marichal T, Ohata K, Bedoret D, Mesnil C, Sabatel C, Kobiyama K, Lekeux P, Coban C, Akira S, Ishii KJ, Bureau F, Desmet CJ
    • Journal Title

      Nat Med

      Volume: 17(8) Issue: 8 Pages: 996-1002

    • DOI

      10.1038/nm.2403

    • Data Source
      KAKENHI-PROJECT-21390152
  • [Journal Article] Serologic Markers in Relation to Parasite Exposure History Help to Estimate Transmission Dynamics of Plasmodium vivax2011

    • Author(s)
      Yildiz Zeyrek F, Palacpac N, Yuksel F, Yagi M, Honjo K, Fujita Y, Arisue N, Takeo S, Tanabe K, Horii T, Tsuboi T, Ishii KJ, Coban C
    • Journal Title

      PLoS ONE

      Volume: 6(11) Issue: 11 Pages: e28126-e28126

    • DOI

      10.1371/journal.pone.0028126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Evidences of Protection Against Blood-stage Infection of Plasmodium falciparum by the Novel Protein Vaccine SE362010

    • Author(s)
      Horii T, Shirai H, Jie L, Ishii KJ, Palacpac NQ, Tougan T, Hato M, Ohta N, Bobogare A, Arakaki N, Matsumoto Y, Namazue J, Ishikawa T, Ueda S, Takahashi M
    • Journal Title

      Parasitol Int.

      Volume: 59(3) Pages: 380-386

    • NAID

      10029825230

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] Immunogenicity of Whole Parasite Vaccines Against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR92010

    • Author(s)
      Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nunez G, Ishii KJ, Akira S
    • Journal Title

      Cell Host and Microbe

      Volume: 7(1) Pages: 50-61

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.2010

    • Author(s)
      Reimer T, Shaw MH, Franchi L, Coban C, Ishii KJ, Akira S, Horii T, Rodriguez A, Nunez G.
    • Journal Title

      Eur J Immunol 40(3)

      Pages: 764-769

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine2010

    • Author(s)
      Coban C, Horii T, Akira S, Ishii KJ
    • Journal Title

      Expert Rev Vaccines

      Volume: 9(7) Pages: 775-784

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] The malarial metabolite hemozoin and its potential use as a vaccine adjuvant2010

    • Author(s)
      Coban C*, Yagi M, Ohata K, Igari Y, Tsukui T, Horii T, Ishii KJ, Akira S
    • Journal Title

      Review, Allergology International

      Volume: 59(2)(in press)

    • NAID

      10029669847

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes2010

    • Author(s)
      S.Koyama, T.Aoshi, T.Tanimoto, Y.Kumagai, K.Kobiyama, T.Tougan, K.Sakurai, C.Coban, T.Horii, S.Akira, K.J.Ishii
    • Journal Title

      Sci.Transl.Med. 2(In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Journal Article] Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9.2010

    • Author(s)
      Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nunez G, Ishii KJ, Akira S.
    • Journal Title

      Cell Host Microbe. 21(7)

      Pages: 50-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] TLR9 and Endogenous Adjuvants of the Whole Blood-stage Malaria Vaccine2010

    • Author(s)
      Coban C*, Horii T, Akira S, Ishii KJ
    • Journal Title

      Review, Expert Reviews of Vaccines

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-22790394
  • [Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes2010

    • Author(s)
      Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ
    • Journal Title

      Sci Transl Med

      Volume: 2 Issue: 25 Pages: 24-25

    • DOI

      10.1126/scitranslmed.3000759

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390152, KAKENHI-PROJECT-22700455, KAKENHI-PROJECT-22790461
  • [Journal Article] The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant2010

    • Author(s)
      Coban C, Yagi M, Ohata K, Igari Y, Tsukui T, Horii T, Ishii KJ, Akira S
    • Journal Title

      Allergol Int.

      Volume: 59(2) Pages: 115-124

    • NAID

      10029669847

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] 細胞内DNA 受容体2009

    • Author(s)
      小山正平、審良静男、石井健
    • Journal Title

      Medical Science Digest 1月号

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Innate immune control of nucleic acid-based vaccine immunogenicity.2009

    • Author(s)
      Koyama S, Coban C, Aoshi T, Horii T, Akira S, Ishii KJ*.
    • Journal Title

      Exp.Rev.Vaccines 8

      Pages: 1099-1107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Journal Article] Molecular and cellular mechanisms of DNA vaccines2008

    • Author(s)
      Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ.
    • Journal Title

      Hum Vaccin 4(6)(Corresponding author)

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines2008

    • Author(s)
      Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S.
    • Journal Title

      Nature 451(7179)(Co-corresponding author)

      Pages: 725-9

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Innate immune response to viral infection2008

    • Author(s)
      Koyama S, Ishii KJ, Coban C, Akira S.
    • Journal Title

      Cytokine 43(3)

      Pages: 336-41

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Molecular and cellular mechanisms of DNA vaccines.2008

    • Author(s)
      Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ*.
    • Journal Title

      Hum Vaccine. 4(6).

      Pages: 453-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] TANK-binding kinase-1 delineates innate and adaptiveimmune responses to DNA vaccines.2008

    • Author(s)
      Ishii KJ, et. al.
    • Journal Title

      NATURE 451(7179)

      Pages: 725-729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Intracellular DNA sensors in immunity2008

    • Author(s)
      Takeshita F, Ishii KJ.
    • Journal Title

      Curr Opin Immunol 20(4)(Corresponding author)

      Pages: 383-8

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Host innate immune receptors and beyond : making sense ofmicrobial infections.2008

    • Author(s)
      Ishii KJ*, Koyama S, Nakagawa A, Coban C, Akira s.
    • Journal Title

      Cell Host Microbe. 3(6)

      Pages: 352-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] DNAワクチンのあらたな免疫学的作用機序2008

    • Author(s)
      青枝大貴、小山正平、チョバン・ジェヴァイア、石井健
    • Journal Title

      医学のあゆみ 227(5)

      Pages: 387-392

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] ウイルス感染防御におけるTLRとRLRの役割2008

    • Author(s)
      小山正平、審良静男、石井健
    • Journal Title

      臨床免疫・アレルギー科 50(6)

      Pages: 715-720

    • NAID

      40016414674

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 52008

    • Author(s)
      Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S.
    • Journal Title

      Nat Immunol 9(7)

      Pages: 769-76

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] DNAワクチン作用機序の鍵としてのTANK-binding kinase-1(TBK1)2008

    • Author(s)
      石井健
    • Journal Title

      感染炎症免疫 Vol.38.(3)

      Pages: 275-277

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Intracellular DNA sensors in immunity2008

    • Author(s)
      Takeshita F, Ishii KJ*
    • Journal Title

      Curr Opin Immunol. 20(4)

      Pages: 383-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] ウイルスワクチン用のアジュバント2008

    • Author(s)
      小山正平、ジェバイアチョバン、審良静男、堀井俊宏、石井健
    • Journal Title

      VIRUS REPORT Vol.5 No.1

      Pages: 74-81

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Host innate immune receptors and beyond : making sense of microbial infections2008

    • Author(s)
      Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S.
    • Journal Title

      Cell Host Microbe 3(6)(Co-corresponding author)

      Pages: 352-63

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] ワクチンとアジュバント2008

    • Author(s)
      小山正平、石井健、審良静男
    • Journal Title

      インフルエンザ 9(4)

      Pages: 283-291

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Potential link between the immune system and metabolism of nucleic acids2008

    • Author(s)
      Ishii KJ, Akira S.
    • Journal Title

      Curr Opin Immunol 20(5)(Corresponding author)

      Pages: 524-9

    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Toll or toll-free adjuvant path toward the optimalvaccine development.2007

    • Author(s)
      Ishii KJ, Akira S.
    • Journal Title

      J Clin Immunol. 27(4)

      Pages: 363-371

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Journal Article] Pathological role of Toll-like receptor signaling in cerebral malaria.2007

    • Author(s)
      Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S
    • Journal Title

      Int Immunol. 19

      Pages: 67-79

    • NAID

      10020112335

    • Data Source
      KAKENHI-PLANNED-18073013
  • [Journal Article] 皮膚スメア検査のアンケート2007

    • Author(s)
      石井 則久
    • Journal Title

      日本ハンセン病学会誌 76

      Pages: 227-227

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659128
  • [Journal Article] 2006年における世界のハンセン病の現況について2007

    • Author(s)
      石井 則久
    • Journal Title

      日本ハンセン病学会誌 76

      Pages: 19-19

    • Data Source
      KAKENHI-PROJECT-18659128
  • [Journal Article] ハンセン病制圧後のハンセン病対策戦略。2006

    • Author(s)
      石井則久
    • Journal Title

      日本ハンセン病学会誌 75

      Pages: 239-239

    • Data Source
      KAKENHI-PROJECT-18659128
  • [Journal Article] 世界のハンセン病の現況。2006

    • Author(s)
      石井則久
    • Journal Title

      日本ハンセン病学会誌 75

      Pages: 41-41

    • Data Source
      KAKENHI-PROJECT-18659128
  • [Journal Article] 新たな結核検査 クオンティフェロン^【○!R】TB-2G。2006

    • Author(s)
      石井則久
    • Journal Title

      皮膚科の臨床 48

      Pages: 1377-1377

    • Data Source
      KAKENHI-PROJECT-18659128
  • [Journal Article] らい菌の遺伝子診断の現状。2006

    • Author(s)
      石井則久
    • Journal Title

      日本ハンセン病学会誌 75

      Pages: 261-261

    • Data Source
      KAKENHI-PROJECT-18659128
  • [Patent] 病原性グラム陰性菌に対するワクチン2018

    • Inventor(s)
      佐和貞治、石井健、濱岡早枝子、内藤慶史
    • Industrial Property Rights Holder
      佐和貞治、石井健、濱岡早枝子、内藤慶史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-15H05008
  • [Patent] 新規マラリアワクチン及びアジュバント2009

    • Inventor(s)
      堀井俊宏、石井 健、東岸任弘
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Filing Date
      2009-04-28
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Patent] 新規マラリアワクチン及びアジュバント2009

    • Inventor(s)
      堀井俊宏、石井健、東岸任弘
    • Industrial Property Rights Holder
      国立大学法人大阪大学
    • Filing Date
      2009-04-30
    • Overseas
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Patent] 新規アジュバント2007

    • Inventor(s)
      審良静男, 石井 健, チョバンジェヴィイア, 津久井利広
    • Industrial Property Rights Holder
      国立大学法人大阪大学日本全薬工業
    • Industrial Property Number
      2007-285737
    • Filing Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Patent] Zc3ch12機能抑制物質および自然免疫賦活剤を用いた

    • Inventor(s)
      審良静男、竹内理、松下一史、石井健
    • Industrial Property Number
      2009-046990
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Patent] 新規アジュバント

    • Inventor(s)
      審良静男、石井健、チョバンジェヴァイア、津久井利広
    • Industrial Property Rights Holder
      国立大学法人大阪大学、日本全薬工業
    • Industrial Property Number
      2007-285737
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] In situ vaccine combining TLR9 nanoligand K3-SPG and near-infrared photoimmu notherapy evokes potent antitumor immunity2023

    • Author(s)
      Hiroaki Yaku, Ken Takahashi, Hirokazu Okada, Kouji Kobiyama, Masahiro Shiokawa, Norimitsu Uza, Ken J. Ishii, Hiroshi Seno
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K07386
  • [Presentation] Endo- and Exogenous Adjuvant for Influenza Vaccination2011

    • Author(s)
      Ishii KJ
    • Organizer
      Keystone Symposia Pathogenesis of Influenza : Virus-Host Interactions
    • Place of Presentation
      Hong Kong(招待講演)
    • Year and Date
      2011-05-26
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Lipocalin 2 and the iron metabolism during malaria infection2011

    • Author(s)
      Coban C, Zhao H, Yagi M, Aoshi T, Horii T, Ishii KJ, Akira S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)(Oral presentation)
    • Data Source
      KAKENHI-PROJECT-22790394
  • [Presentation] Lipocalin 2 and the iron metabolism during malaria infection2011

    • Author(s)
      Coban C, Zhao H, Yagi M, Aoshi T, Horii T, Ishii KJ, Akira S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Data Source
      KAKENHI-PROJECT-22790394
  • [Presentation] Endo-and Exogenous Adjuvant for Influenza Vaccination2011

    • Author(s)
      Ishii KJ
    • Organizer
      Keystone Symposia Pathogenesis of Influenza : Virus-Host Interactions
    • Place of Presentation
      Hong Kong
    • Year and Date
      2011-05-26
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Innate immune signaling pathways essential for DNA and viral vaccines2010

    • Author(s)
      Ken J.Ishii
    • Organizer
      KEYSTONE SYMPOSIA
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Innate Immune Mechanisms of Vaccines2010

    • Author(s)
      Ken J.Ishii
    • Organizer
      The 2010 Fall Conference of The Korean Association of Immunologists
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-11-20
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Innate control of vaccine immunogenicity by nucleic acid adjuvants2010

    • Author(s)
      Ken J.Ishii
    • Organizer
      Cold Spring Harbor Meeting China
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-11-07
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Plasmacytoid dendritic cells in influenza vaccine response2010

    • Author(s)
      Ken J.Ishii
    • Organizer
      4^<th> European Congress of Virology
    • Place of Presentation
      Como, Italy
    • Year and Date
      2010-04-08
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR92010

    • Author(s)
      M.Yagi, T.Horii T., Tougan, T.Arisue, N.Palacpac M.Q, K.J.Ishii, C.Coban
    • Organizer
      The 4th International RIMD-CVRDC Joint Symposium
    • Place of Presentation
      岡山市、岡山/日本
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PLANNED-18073013
  • [Presentation] Manipulation of vaccine immunogenicity by innate immune mechanisms2009

    • Author(s)
      Ishii KJ
    • Organizer
      CVRDC-RIMD Symposium
    • Place of Presentation
      Korea
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] Innate immune control of influenza vaccine immunogenicity2009

    • Author(s)
      ISHII KJ
    • Organizer
      3^<rd> Vaccine global congress
    • Place of Presentation
      シンガポール
    • Year and Date
      2009-11-03
    • Data Source
      KAKENHI-PROJECT-21390152
  • [Presentation] Innate immunity and vaccine development2008

    • Author(s)
      Ishii, KJ
    • Organizer
      Primate Research Forum
    • Place of Presentation
      Tsukuba, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] Immune recognition of nucleic acids and vaccine development2008

    • Author(s)
      Ishii, KJ.
    • Organizer
      National Target Protein Research Program Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] TLR-based adjuvants and their molecular mechanisms2008

    • Author(s)
      Ishii, KJ
    • Organizer
      Vaccine forum
    • Place of Presentation
      Osaka Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] DNA vaccines and vaccine adjuvants2008

    • Author(s)
      Ishii, KJ.
    • Organizer
      AJMITR conference
    • Place of Presentation
      Hanoi, Vietnam
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] Pivotal role of innate immune recognition and signaling pathways in vaccine immunogenicity2008

    • Author(s)
      Ishii, KJ
    • Organizer
      Symposium, Annual meeting of Japanese society of Biochemistry and Molecular Biology (BMB2008)
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] Innate and adaptive immune recognition of DNA vaccines2008

    • Author(s)
      Ishii, KJ
    • Organizer
      73rd Japanese Society of interferon and cytokine research symposium
    • Place of Presentation
      Sapporo, Hokkaido Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] "Innate Recognition Receptors and Signaling Pathways" Plenary talk2007

    • Author(s)
      Ishii KJ
    • Organizer
      1st International Congress of Society of Innate Immunity
    • Place of Presentation
      Ankara, Turkey
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] "Immune recognition of nucleic acids and vaccine development" Plenary talk2007

    • Author(s)
      Ishii, KJ.
    • Organizer
      The 39th annual meeting of Japanese Society of Pediatric Infectious Diseases
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-11-01
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] 拡散による自然免疫制御とワクチン開発2007

    • Author(s)
      石井 健
    • Organizer
      日本小児感染症学会 特別講演
    • Place of Presentation
      東京
    • Year and Date
      2007-11-10
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] "Innate immunity and vaccine development" Bio business seminar2007

    • Author(s)
      Ishii, KJ.
    • Organizer
      The Osaka Chamber of Commerce and Industry
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] "Innate immunity and vaccine development" Bioscience seminar2007

    • Author(s)
      Ishii, KJ.
    • Organizer
      National Institute for Biomedical Innovation
    • Place of Presentation
      Osaka, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.2007

    • Author(s)
      石井 健, 他
    • Organizer
      日本免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] TLR, DNA hemozoin and beyond2007

    • Author(s)
      Ishii KJ
    • Organizer
      Awaji International meeting
    • Place of Presentation
      Awaji Hyogo Japan
    • Year and Date
      2007-09-04
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] Innate immune recognition2007

    • Author(s)
      Ishii KJ
    • Organizer
      1st International innate immunity congress Key note speaker
    • Place of Presentation
      Ankara Turkey
    • Year and Date
      2007-05-14
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] TLR9 recognition of DNA and hemozoin, and beyond2007

    • Author(s)
      Ishii, KJ
    • Organizer
      The 7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji island, Japan
    • Data Source
      KAKENHI-PROJECT-19390139
  • [Presentation] TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.2007

    • Author(s)
      石井 健, 他
    • Organizer
      Naito Conference
    • Place of Presentation
      Hayama Kanagawa Japan
    • Year and Date
      2007-10-12
    • Data Source
      KAKENHI-PROJECT-19390139
  • 1.  HORII Toshihiro (80142305)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 18 results
  • 2.  COBAN Cevayir (00397712)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 21 results
  • 3.  TAKAHASHI Ken (60594372)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  TANABE Kazuyuki (40047410)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  ARISUE Nobuko (00242339)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  TOUGAN Takahiro (20379093)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  TAI Kumiko (00187907)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  YAGI Masanori (60452463)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 9.  TAKESHITA FUMIHIKO (60333572)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 10.  AKIRA Shizuo (50192919)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 27 results
  • 11.  HAYAKAWA Toshiyuki (80418681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Masumoto Junya (20334914)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Kuroda Etsushi (10299604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Sawa Teiji (10206013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  鈴木 幸一 (20206478)
    # of Collaborated Projects: 1 results
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  • 16.  伊藤 有紀 (10608334)
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  • 17.  澤崎 達也 (50314969)
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  • 18.  上松 一永 (60262721)
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  • 19.  右田 清志 (60264214)
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  • 20.  大澤 春彦 (90294800)
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  • 21.  森山 潔 (10296717)
    # of Collaborated Projects: 1 results
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  • 22.  天谷 文昌 (60347466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  中屋 隆明 (80271633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  宇座 徳光 (30447958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 25.  KOYAMA Shohei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 26.  KAWAGOE Tatsukata
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 27.  Ozoren Nesrin
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  Kaneko Naoe
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  PALACPAC Nirianne M. Q.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  ZEYREK Fadile Yildiz
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  UDOMSANGPETCH Rachanee
    # of Collaborated Projects: 1 results
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  • 32.  SATTABONGKOT Jetsumon
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  • 33.  CULLETON Richard
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  • 34.  妹尾 浩
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