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Horiuchi Keiko  堀内 恵子

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HORIUCHI Keiko  堀内 恵子

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Researcher Number 00456203
Other IDs
Affiliation (Current) 2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2021 – 2022: 横浜市立大学, 医学部, 助教
2020: 日本医科大学, 先端医学研究所, 助教
2013 – 2017: 東京大学, 先端科学技術研究センター, 助教
2012: 東京大学, 先端科学技術研究センター, 特任助教
2008 – 2009: The University of Tokyo, 先端科学技術研究センター, 特任助教
Review Section/Research Field
Principal Investigator
Basic Section 42030:Animal life science-related / Genome biology / Molecular biology
Except Principal Investigator
Biomolecular chemistry / Living organism molecular science
Keywords
Principal Investigator
RNAスプライシング / 細胞周期 / 精子形成 / RNAスプラシング / 骨髄異形成症候群 / マイナースプライシオソーム / スプライシング / ZRSR / スプラシイング / ZRSR1 … More / Targeted proteomics / プロテオミクス / exon definition / ZRSR2 / minor spliceosome / RNA seq / RNAseq / オルタナティブスプライシング / SUV420H2 / WTAP / 分子間相互作用 / プロテオミクス解析 / マイクロアレイ / プロテオーム / 発現制御 … More
Except Principal Investigator
RNAプロセッシング / 細胞周期 / スプライシング / コンピュータシミュレーション / 分子認識 / タンパク質相互作用 / ヒストン / 血管内皮細胞 / オルタナティブスプライシング / パターン認識受容体 / 自然免疫 / ペントラキシン / ヒストン障害 / 敗血症 / モノクローナル抗体 / 核タンパク質 / 軟X線顕微鏡 / 核内受容体 / 軟X線顕微鏡 / 生体イメージング / ヒストン修飾 / 核微細構造 / クロマチン修飾 / 核小体 / 核スペックル / 転写調節 / 複合体解析 / プロテオミクス Less
  • Research Projects

    (5 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (17 People)
  •  Study of splicing factor ZRSR1 in spermatogenesis for therapeutic applicationPrincipal Investigator

    • Principal Investigator
      HORIUCHI Keiko
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42030:Animal life science-related
    • Research Institution
      Yokohama City University
      Nippon Medical School
  •  Functional analysis of WTAP protein complex on alternative splicingPrincipal Investigator

    • Principal Investigator
      Horiuchi Keiko
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Genome biology
    • Research Institution
      The University of Tokyo
  •  Dynamics of Molecular Pattern Recognition in Protein Interaction

    • Principal Investigator
      HAMAKUBO TAKAO
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      The University of Tokyo
  •  Dynamic Proteomics of Transcriptional and Nuclear Architecture

    • Principal Investigator
      HAMAKUBO Takao
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Living organism molecular science
    • Research Institution
      The University of Tokyo
  •  The Dynamics of a novel protein complex involved in RNA processing and cell cycle regulationPrincipal Investigator

    • Principal Investigator
      HORIUCHI Keiko
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      The University of Tokyo

All 2022 2021 2016 2013 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development2022

    • Author(s)
      Gomez-Redondo Isabel、Pericuesta Eva、Navarrete-Lopez Paula、Ramos-Ibeas Priscila、Planells Benjamin、Fonseca-Balvis Noelia、Vaquero-Rey Aida、Fernandez-Gonzzlez Raul、Laguna-Barraza Ricardo、Horiuchi Keiko、Gutierrez-Adan Alfonso
    • Journal Title

      iScience

      Volume: 25 Issue: 2 Pages: 103860-103860

    • DOI

      10.1016/j.isci.2022.103860

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06448
  • [Journal Article] Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences2021

    • Author(s)
      Horiuchi Keiko、Kawamura Takeshi、Hamakubo Takao
    • Journal Title

      Journal of Biological Chemistry

      Volume: 297 Issue: 5 Pages: 101248-101248

    • DOI

      10.1016/j.jbc.2021.101248

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06448
  • [Journal Article] Suppression of Slit2/ROBO1 mediated HUVEC migration by Robo42016

    • Author(s)
      Enomoto S, Mitsui K, Kawamura T, Iwanari H, Daigo K, Horiuchi K, Minami T, Kodama T, Hamakubo T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 469 Issue: 4 Pages: 797-802

    • DOI

      10.1016/j.bbrc.2015.12.075

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01348, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-26640069, KAKENHI-PROJECT-26290035
  • [Journal Article] Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.2013

    • Author(s)
      Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 46 Pages: 33292-33302

    • DOI

      10.1074/jbc.m113.500397

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205
  • [Presentation] Interaction of major and minor spliceosomes in regulating splicing of U12-type introns2022

    • Author(s)
      堀内恵子、高橋秀尚、Juan Valcarcel
    • Organizer
      第45回日本分子生物学会年会(サイエンスピッチに採択)
    • Data Source
      KAKENHI-PROJECT-20K06448
  • [Presentation] WTAP複合体によるオルタナティブスプライシング/ポリアデニレーション制御とG-quadruplex配列の関与、Identification of WTAP complex-regulated alternative splicing/polyadenylation reveals potential G-quadruplex-forming sequences at splice sites2021

    • Author(s)
      堀内恵子
    • Organizer
      第44回日本分子生物学会年会、【ワークショップ:[3AW-07]機能性RNAネットワークによる生体恒常性の維持】
    • Data Source
      KAKENHI-PROJECT-20K06448
  • [Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression2012

    • Author(s)
      Keiko Horiuchi
    • Organizer
      Gordon conference, The biology of post-transcriptionalgene regulation
    • Place of Presentation
      アメリカ
    • Year and Date
      2012-07-17
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression.2012

    • Author(s)
      Keiko Horiuchi
    • Organizer
      Gordon conference, The biology of post-transcriptional gene regulation .
    • Place of Presentation
      ロードアイランド(アメリカ)
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] WTAP複合体の同定及び機能解析2011

    • Author(s)
      堀内恵子
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-09-24
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] プロセツシングおよび細胞周期を制御する新規複合体の機能解析2010

    • Author(s)
      堀内恵子, 川村猛, 浜窪隆雄
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] プロセッシングおよび細胞周期を制御する新規複合体の機能解析2010

    • Author(s)
      堀内恵子, 川村猛, 浜窪隆雄
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] CDGAPはROBO1と相互作用して血管内皮細胞のSLIT2依存的な遊走に関与する2010

    • Author(s)
      根本悟士, 川村猛, 岩成宏子, 太期健二, 堀内恵子, 南敬, 児玉龍彦, 浜窪隆雄
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009

    • Author(s)
      堀内恵子
    • Organizer
      第21回高遠シンポジウム
    • Place of Presentation
      長野県伊那市
    • Year and Date
      2009-08-27
    • Data Source
      KAKENHI-PROJECT-20770134
  • [Presentation] 核内因子WTAPはcyclin A2 mRNAを安定 化しG2/M期移行を制御する2009

    • Author(s)
      堀内恵子
    • Organizer
      第21回高遠シンポジウム
    • Place of Presentation
      長野
    • Year and Date
      2009-08-27
    • Data Source
      KAKENHI-PROJECT-20221010
  • [Presentation] 核内因子WTAPは cyclin A2 mRNAを安定化しG2/M期移行を制御する2009

    • Author(s)
      堀内恵子
    • Organizer
      第21回高遠シンポジウム
    • Place of Presentation
      長野県伊那市
    • Year and Date
      2009-08-27
    • Data Source
      KAKENHI-PROJECT-20770134
  • [Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009

    • Author(s)
      堀内恵子
    • Organizer
      第21回高遠シンポジウム
    • Place of Presentation
      高遠さくらホテル
    • Year and Date
      2009-08-27
    • Data Source
      KAKENHI-PROJECT-20221010
  • 1.  HAMAKUBO Takao (90198797)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 2.  IWANARI Hiroko (20176556)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  KAWAMURA Takeshi (70306835)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  DAIGO Kenji (20466866)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  NAITO Makoto (30045786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIYOSHI Motosuke (40345137)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  IHARA Shigeo (30345136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MOCHIZUKI Yasuhiro (80282523)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SAKIHAMA Toshiko (70187061)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OHTA Yoshihiro (80436592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OHASHI Riuko (20447600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Fujitani Hideaki (50417151)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Nagatoishi Satoru (30550248)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Yamashita Takefumi (50615622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  篠田 恵子 (80646951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  津本 浩平 (90271866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  南 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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