Horiuchi Keiko 堀内恵子

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HORIUCHI Keiko 堀内恵子

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Researcher Number	00456203
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 横浜市立大学, 医学部, 助教 2020: 日本医科大学, 先端医学研究所, 助教 2013 – 2017: 東京大学, 先端科学技術研究センター, 助教 2012: 東京大学, 先端科学技術研究センター, 特任助教 2008 – 2009: The University of Tokyo, 先端科学技術研究センター, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 42030:Animal life science-related / Genome biology / Molecular biology Except Principal Investigator Biomolecular chemistry / Living organism molecular science
Keywords	Principal Investigator RNAスプライシング / 細胞周期 / 精子形成 / RNAスプラシング / 骨髄異形成症候群 / マイナースプライシオソーム / スプライシング / ZRSR / スプラシイング / ZRSR1 … More / Targeted proteomics / プロテオミクス / exon definition / ZRSR2 / minor spliceosome / RNA seq / RNAseq / オルタナティブスプライシング / SUV420H2 / WTAP / 分子間相互作用 / プロテオミクス解析 / マイクロアレイ / プロテオーム / 発現制御 … More Except Principal Investigator RNAプロセッシング / 細胞周期 / スプライシング / コンピュータシミュレーション / 分子認識 / タンパク質相互作用 / ヒストン / 血管内皮細胞 / オルタナティブスプライシング / パターン認識受容体 / 自然免疫 / ペントラキシン / ヒストン障害 / 敗血症 / モノクローナル抗体 / 核タンパク質 / 軟X線顕微鏡 / 核内受容体 / 軟Ｘ線顕微鏡 / 生体イメージング / ヒストン修飾 / 核微細構造 / クロマチン修飾 / 核小体 / 核スペックル / 転写調節 / 複合体解析 / プロテオミクス Less

Study of splicing factor ZRSR1 in spermatogenesis for therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Keiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  Yokohama City University
  Nippon Medical School
Functional analysis of WTAP protein complex on alternative splicingPrincipal Investigator
- Principal Investigator
  
  Horiuchi Keiko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  The University of Tokyo
Dynamics of Molecular Pattern Recognition in Protein Interaction
- Principal Investigator
  
  HAMAKUBO TAKAO
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  The University of Tokyo
Dynamic Proteomics of Transcriptional and Nuclear Architecture
- Principal Investigator
  
  HAMAKUBO Takao
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
The Dynamics of a novel protein complex involved in RNA processing and cell cycle regulationPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Keiko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo

All 2022 2021 2016 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development2022
- Author(s)
  Gomez-Redondo Isabel、Pericuesta Eva、Navarrete-Lopez Paula、Ramos-Ibeas Priscila、Planells Benjamin、Fonseca-Balvis Noelia、Vaquero-Rey Aida、Fernandez-Gonzzlez Raul、Laguna-Barraza Ricardo、Horiuchi Keiko、Gutierrez-Adan Alfonso
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 2 Pages: 103860-103860
- DOI
  10.1016/j.isci.2022.103860
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06448
[Journal Article] Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences2021
- Author(s)
  Horiuchi Keiko、Kawamura Takeshi、Hamakubo Takao
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 5 Pages: 101248-101248
- DOI
  10.1016/j.jbc.2021.101248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06448
[Journal Article] Suppression of Slit2/ROBO1 mediated HUVEC migration by Robo42016
- Author(s)
  Enomoto S, Mitsui K, Kawamura T, Iwanari H, Daigo K, Horiuchi K, Minami T, Kodama T, Hamakubo T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 469 Issue: 4 Pages: 797-802
- DOI
  10.1016/j.bbrc.2015.12.075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01348, KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-26640069, KAKENHI-PROJECT-26290035
[Journal Article] Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.2013
- Author(s)
  Horiuchi K, Kawamura T, Iwanari H, Ohashi R, Naito M, Kodama T, Hamakubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 46 Pages: 33292-33302
- DOI
  10.1074/jbc.m113.500397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108007, KAKENHI-PROJECT-25220205
[Presentation] Interaction of major and minor spliceosomes in regulating splicing of U12-type introns2022
- Author(s)
  堀内恵子、高橋秀尚、Juan Valcarcel
- Organizer
  第45回日本分子生物学会年会（サイエンスピッチに採択）
- Data Source
  KAKENHI-PROJECT-20K06448
[Presentation] WTAP複合体によるオルタナティブスプライシング/ポリアデニレーション制御とG-quadruplex配列の関与、Identification of WTAP complex-regulated alternative splicing/polyadenylation reveals potential G-quadruplex-forming sequences at splice sites2021
- Author(s)
  堀内恵子
- Organizer
  第44回日本分子生物学会年会、【ワークショップ：[3AW-07]機能性RNAネットワークによる生体恒常性の維持】
- Data Source
  KAKENHI-PROJECT-20K06448
[Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression2012
- Author(s)
  Keiko Horiuchi
- Organizer
  Gordon conference, The biology of post-transcriptionalgene regulation
- Place of Presentation
  アメリカ
- Year and Date
  2012-07-17
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression.2012
- Author(s)
  Keiko Horiuchi
- Organizer
  Gordon conference, The biology of post-transcriptional gene regulation .
- Place of Presentation
  ロードアイランド（アメリカ）
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] WTAP複合体の同定及び機能解析2011
- Author(s)
  堀内恵子
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] プロセツシングおよび細胞周期を制御する新規複合体の機能解析2010
- Author(s)
  堀内恵子, 川村猛, 浜窪隆雄
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] プロセッシングおよび細胞周期を制御する新規複合体の機能解析2010
- Author(s)
  堀内恵子, 川村猛, 浜窪隆雄
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] CDGAPはROBO1と相互作用して血管内皮細胞のSLIT2依存的な遊走に関与する2010
- Author(s)
  根本悟士, 川村猛, 岩成宏子, 太期健二, 堀内恵子, 南敬, 児玉龍彦, 浜窪隆雄
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009
- Author(s)
  堀内恵子
- Organizer
  第21回高遠シンポジウム
- Place of Presentation
  長野県伊那市
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20770134
[Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009
- Author(s)
  堀内恵子
- Organizer
  第21回高遠シンポジウム
- Place of Presentation
  長野
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20221010
[Presentation] 核内因子WTAPは cyclin A2 mRNAを安定化しG2/M期移行を制御する2009
- Author(s)
  堀内恵子
- Organizer
  第21回高遠シンポジウム
- Place of Presentation
  長野県伊那市
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20770134
[Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009
- Author(s)
  堀内恵子
- Organizer
  第21回高遠シンポジウム
- Place of Presentation
  高遠さくらホテル
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20221010

1. HAMAKUBO Takao (90198797)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. IWANARI Hiroko (20176556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. KAWAMURA Takeshi (70306835)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. DAIGO Kenji (20466866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. NAITO Makoto (30045786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYOSHI Motosuke (40345137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IHARA Shigeo (30345136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MOCHIZUKI Yasuhiro (80282523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SAKIHAMA Toshiko (70187061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHTA Yoshihiro (80436592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OHASHI Riuko (20447600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Fujitani Hideaki (50417151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Nagatoishi Satoru (30550248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Yamashita Takefumi (50615622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 篠田恵子 (80646951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 津本浩平 (90271866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 南敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Horiuchi Keiko 堀内 恵子

HORIUCHI Keiko 堀内 恵子

Research Projects

Research Products

Co-Researchers

Study of splicing factor ZRSR1 in spermatogenesis for therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of WTAP protein complex on alternative splicingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamics of Molecular Pattern Recognition in Protein Interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dynamic Proteomics of Transcriptional and Nuclear Architecture

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Dynamics of a novel protein complex involved in RNA processing and cell cycle regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Suppression of Slit2/ROBO1 mediated HUVEC migration by Robo42016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Interaction of major and minor spliceosomes in regulating splicing of U12-type introns2022

Author(s)

Organizer

Data Source

[Presentation] WTAP複合体によるオルタナティブスプライシング/ポリアデニレーション制御とG-quadruplex配列の関与、Identification of WTAP complex-regulated alternative splicing/polyadenylation reveals potential G-quadruplex-forming sequences at splice sites2021

Author(s)

Organizer

Data Source

[Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The WTAP complex is a novel RNA processing factor required for cell cycle progression.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] WTAP複合体の同定及び機能解析2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

Horiuchi Keiko 堀内恵子

HORIUCHI Keiko 堀内恵子

[Presentation] 核内因子WTAPはcyclin A2 mRNAを安定化しG2/M期移行を制御する2009