Hayami Shinya 速水晋也

Researcher Number	00468290
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2025: 和歌山県立医科大学, 医学部, 講師 2018: 和歌山県立医科大学, 医学部, 助教 2017: 和歌山県立医科大学, 医学部, その他 2013 – 2017: 和歌山県立医科大学, 医学部, 学内助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Human genetics Except Principal Investigator Basic Section 55020:Digestive surgery-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Digestive surgery
Keywords	Principal Investigator メチル化 / 肝細胞癌 / メチル基転移酵素 / オルガノイド / CRISPR/Cas9 / リンパ節転移 / SMYD2 / 肝内胆管癌 / タンパクメチル化 / 脱メチル化酵素 … More / LSD1 / 脱メチル化 / 分子標的治療薬 / エピジェネティクス / 新規分子標的治療薬 / メチル基置換酵素 / SETD8 … More Except Principal Investigator 免疫チェックポイント阻害剤 / 肝細胞癌 / 腫瘍微小環境 / メチル化 / 膵癌 / 微生物由来細胞外小胞 / 胆管癌 / 癌ワクチン療法 / 脳内ホルモン / 仮想現実 / 緩和ケア / エクソソーム / 肝内胆管癌 / 癌微小環境 / 抗癌剤 / 癌 / ゲノム / 分子標的治療剤 / 原発性肝癌 Less

エピゲノム解析を用いたクロマチンダイナミクスに基づく肝細胞癌増殖メカニズムの解明Principal Investigator
- Principal Investigator
  
  速水晋也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
樹状細胞サブセットに注目した新規抗がんワクチンの胆道癌集学的治療への応用
- Principal Investigator
  
  宮本篤
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
微生物由来細胞外小胞と腫瘍免疫微小環境の関連性に関する探索的研究
- Principal Investigator
  
  上野昌樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
新規分子標的治療薬開発に向けたタンパクメチル化を介する膵癌増殖メカニズムの解明
- Principal Investigator
  
  吉村知紘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
オルガノイドを用いたメチル基転移酵素による肝内胆管癌リンパ節転移の機序解明Principal Investigator
- Principal Investigator
  
  速水晋也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
Innovation of palliative medicine using the technology of virtual reality in cancer patients
- Principal Investigator
  
  山上裕機
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Wakayama Medical University
Exploreatory research of drug resistance mechanisms based on exosome information in the cancer microenvironment
- Principal Investigator
  
  Ueno Masaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Wakayama Medical University
Exploratory research of driver gene mutation and drug sensitivity-related genes expression changes in hepatocellular carcinoma
- Principal Investigator
  
  UENO Masaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Wakayama Medical University
Development of the novel cancer agents targetting LSD1 for hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Hayami Shinya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  Wakayama Medical University
Discover of histone methyltransferase SETD8-targeting therapy for HCC patients.Principal Investigator
- Principal Investigator
  
  Hayami Shinya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human genetics
- Research Institution
  Wakayama Medical University

All 2024 2023 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

[Journal Article] Short-term serial circulating tumor DNA assessment predicts therapeutic efficacy for patients with advanced pancreatic cancer2024
- Author(s)
  Motobayashi Hideki、Kitahata Yuji、Okada Ken-ichi、Miyazawa Motoki、Ueno Masaki、Hayami Shinya、Miyamoto Atsushi、Shimizu Atsushi、Sato Masatoshi、Yoshimura Tomohiro、Nakamura Yuki、Takemoto Norio、Nakai Tomoki、Hyo Takahiko、Matsumoto Kyohei、Yamaue Hiroki、Kawai Manabu
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 150 Issue: 2 Pages: 35-35
- DOI
  10.1007/s00432-023-05594-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-20K09043, KAKENHI-PROJECT-21H04833
[Journal Article] Virtual Reality Images of the Home Are Useful for Patients With Hospital-Based Palliative Care: Prospective Observational Study With Analysis by Text Mining2023
- Author(s)
  Mukai Tomoyo、Tsukiyama Yoshi、Yamada Shinobu、Nishikawa Akinori、Hayami Shinya、Noguchi Rie、Yoshida Junko、Kashiwada Maki、Ohta Shigeru、Shimokawa Toshio、Yamaue Hiroki
- Journal Title
  
  Palliative Medicine Reports
  
  Volume: 4 Issue: 1 Pages: 214-219
- DOI
  10.1089/pmr.2023.0017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833
[Journal Article] Radiographic duodenal invasion is associated with poor prognosis and early recurrence in patients with pancreatic ductal adenocarcinoma2023
- Author(s)
  Miyazawa Motoki、Hirono Seiko、Kawai Manabu、Okada Ken-ichi、Kitahata Yuji、Motobayashi Hideki、Sato Masatoshi、Yoshimura Tomohiro、Ueno Masaki、Hayami Shinya、Miyamoto Atsushi、Shimizu Atsushi、Yamaue Hiroki
- Journal Title
  
  European Journal of Surgical Oncology
  
  Volume: 49 Issue: 10 Pages: 106960-106960
- DOI
  10.1016/j.ejso.2023.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-22K08782, KAKENHI-PROJECT-21K08803, KAKENHI-PROJECT-21H04833
[Journal Article] Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.2023
- Author(s)
  Kato Hirotaka、Hayami Shinya、Ueno Masaki、Suzaki Norihiko、Nakamura Masashi、Yoshimura Tomohiro、Miyamoto Atsushi、Shigekawa Yoshinobu、Okada Ken‐Ichi、Miyazawa Motoki、Kitahata Yuji、Ehata Shogo、Hamamoto Ryuji、Yamaue Hiroki、Kawai Manabu
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 2 Pages: 385-400
- DOI
  10.1111/cas.16038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833
[Journal Article] Response Prediction Model of Atezolizumab plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Multicenter Retrospective Study2023
- Author(s)
  Ueno Masaki、Kosaka Hisashi、Iida Hiroya、Ida Yoshiyuki、Aoi Kazunori、Mori Haruki、Miyamoto Atsushi、Nishida Yuko、Hayami Shinya、Kawai Manabu、Kaibori Masaki
- Journal Title
  
  Oncology
  
  Volume: 101 Issue: 9 Pages: 565-574
- DOI
  10.1159/000531317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09043
[Journal Article] Radiological Shape of the Tumor Predicts Progression and Survival in Resected Extrahepatic Cholangiocarcinoma.2023
- Author(s)
  Okada KI, Kawai M, Hirono S, Miyazawa M, Kitahata Y, Ueno M, Hayami S, Ikoma A, Sonomura T, Wan K, Shimokawa T, Yamaue H.
- Journal Title
  
  J Gastrointest Surg
  
  Volume: - Issue: 6 Pages: 1113-1121
- DOI
  10.1007/s11605-023-05614-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08803, KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-20K09043, KAKENHI-PROJECT-21H04833
[Journal Article] Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets2022
- Author(s)
  Fujita Masashi、Chen Mei-Ju May、Siwak Doris Rieko、Sasagawa Shota、Oosawa-Tatsuguchi Ayako、Arihiro Koji、Ono Atsushi、Miura Ryoichi、Maejima Kazuhiro、Aikata Hiroshi、Ueno Masaki、Hayami Shinya、Yamaue Hiroki、Chayama Kazuaki、Lee Ju-Seog、Lu Yiling、Mills Gordon B.、Liang Han、Nishizuka Satoshi S.、Nakagawa Hidewaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6481-6481
- DOI
  10.1038/s41467-022-34249-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19694, KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-23K24324
[Journal Article] Circulating Tumor DNA as a Potential Prognostic Marker in Patients with Borderline-Resectable Pancreatic Cancer Undergoing Neoadjuvant Chemotherapy Followed by Pancreatectomy.2022
- Author(s)
  Kitahata Y, Kawai M, Hirono S, Okada KI, Miyazawa M, Motobayashi H, Ueno M, Hayami S, Miyamoto A, Yamaue H.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 29 Issue: 3 Pages: 1596-1605
- DOI
  10.1245/s10434-021-10985-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04833, KAKENHI-PROJECT-21K08803, KAKENHI-PROJECT-20K09043
[Journal Article] Prognostic impact of adjuvant chemolipiodolization and treatment frequency on patients with hepatocellular carcinoma after hepatectomy: Prospective study with historical control group2021
- Author(s)
  Masaki Ueno, Shinya Hayami, Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Yuji Kitahata, Atsushi Miyamoto, Norihiko Suzaki, Masashi Nakamura, Hiroki Yamaue
- Journal Title
  
  Surg Oncol.
  
  Volume: 36 Pages: 99-105
- DOI
  10.1016/j.suronc.2020.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10675
[Journal Article] Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations.2020
- Author(s)
  Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H.
- Journal Title
  
  EBioMedicine
  
  Volume: 53 Pages: 102659-102659
- DOI
  10.1016/j.ebiom.2020.102659
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-18K19426, KAKENHI-PROJECT-18H04049, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-18H02680, KAKENHI-PROJECT-18H02696, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-18K19575, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-19K09206
[Journal Article] Effective Response of Intrahepatic Cholangiocarcinoma to Pembrolizumab: A Case Report2020
- Author(s)
  Masashi Nakamura, Masaki Ueno, Shinya Hayami, Manabu Kawai, Atsushi Miyamoto, Norihiko Suzaki, Seiko Hirono, Ken-Ichi Okada, Motoki Miyazawa, Yuji Kitahata, Ryohei Kobayashi, Fumiyoshi Kojima, Hiroki Yamaue
- Journal Title
  
  Anticancer Res.
  
  Volume: 40 Issue: 7 Pages: 4123-4129
- DOI
  10.21873/anticanres.14411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10675
[Journal Article] Prognostic Analysis of Hepatocellular Carcinoma With Hepatitis C Virus Infection Using Epithelial-Mesenchymal Transition Gene Profiles.2020
- Author(s)
  Ueno M, Kawai M, Park JY, Hirono S, Okada KI, Hayami S, Wang HJ, Yamaue H.
- Journal Title
  
  J Surg Res.
  
  Volume: 245 Pages: 302-308
- DOI
  10.1016/j.jss.2019.07.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10675
[Journal Article] Low lymphocyte monocyte ratio after neoadjuvant therapy predicts poor survival after pancreatectomy in patients with borderline resectable pancreatic cancer.2019
- Author(s)
  Kawai M, Hirono S, Okada KI, Miyazawa M, Shimizu A, Kitahata Y, Kobayashi R, Ueno M, Hayami S, Tanioka K, Yamaue H.
- Journal Title
  
  Surgery
  
  Volume: 165 Issue: 6 Pages: 1151-1160
- DOI
  10.1016/j.surg.2018.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-18K08655
[Journal Article] Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.2018
- Author(s)
  Shigekawa Y, Hayami S, Ueno M, Miyamoto A, Suzaki N, Kawai M, Hirono S, Okada KI, Hamamoto R, Yamaue H.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 76 Pages: 34320-34335
- DOI
  10.18632/oncotarget.26144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PUBLICLY-18H04908, KAKENHI-PROJECT-17H01580, KAKENHI-PROJECT-16K15623
[Journal Article] Indocyanine green fluorescence imaging techniques and interventional radiology during laparoscopic anatomical liver resection (with video)2017
- Author(s)
  Ueno Masaki、Hayami Shinya、Sonomura Tetsuo、Tanaka Ryota、Kawai Manabu、Hirono Seiko、Okada Ken-ichi、Yamaue Hiroki
- Journal Title
  
  Surgical Endoscopy
  
  Volume: 32 Issue: 2 Pages: 1051-1055
- DOI
  10.1007/s00464-017-5997-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-17H01580
[Journal Article] Partial clamping of the infrahepatic inferior vena cava for blood loss reduction during anatomic liver resection: A prospective, randomized, controlled trial.2017
- Author(s)
  Ueno M, Kawai M, Hayami S, Hirono S, Okada KI, Uchiyama K, Yamaue H.
- Journal Title
  
  Surgery.
  
  Volume: in press Issue: 6 Pages: 1502-1513
- DOI
  10.1016/j.surg.2016.12.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293308, KAKENHI-PROJECT-17K10675
[Journal Article] Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors2017
- Author(s)
  Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Gotoh K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, Nakagawa H
- Journal Title
  
  J Hepatol
  
  Volume: 66(2) Issue: 2 Pages: 363-373
- DOI
  10.1016/j.jhep.2016.09.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-26293308, KAKENHI-PROJECT-15K19915, KAKENHI-PROJECT-17K10675, KAKENHI-PROJECT-26430196, KAKENHI-PROJECT-15H04814
[Presentation] Overexpression of SETD8 promotes early recurrence in hepatocellular carcinoma2015
- Author(s)
  Shinya Hayami
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25870638

1. 川井学 (40398459)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. UENO Masaki (90405465)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. 山上裕機 (20191190)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
4. 宮本篤 (00756570)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 北畑裕司 (00535338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 吉村知紘 (70908764)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 月山淑 (90264895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 向友代 (20939847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 山田忍 (20611057)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 下川敏雄 (00402090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 勝田将裕 (50464673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 西川彰則 (70618199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 太田茂 (60160503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 清水敦史 (00637910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIRONO Seiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. MIYAZAWA Motoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. SHIRAISHI Yuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 岡田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
19. 井元清哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayami Shinya 速水 晋也

Research Projects

Research Products

Co-Researchers

エピゲノム解析を用いたクロマチンダイナミクスに基づく肝細胞癌増殖メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

樹状細胞サブセットに注目した新規抗がんワクチンの胆道癌集学的治療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

微生物由来細胞外小胞と腫瘍免疫微小環境の関連性に関する探索的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規分子標的治療薬開発に向けたタンパクメチル化を介する膵癌増殖メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オルガノイドを用いたメチル基転移酵素による肝内胆管癌リンパ節転移の機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovation of palliative medicine using the technology of virtual reality in cancer patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploreatory research of drug resistance mechanisms based on exosome information in the cancer microenvironment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research of driver gene mutation and drug sensitivity-related genes expression changes in hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the novel cancer agents targetting LSD1 for hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discover of histone methyltransferase SETD8-targeting therapy for HCC patients.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Short-term serial circulating tumor DNA assessment predicts therapeutic efficacy for patients with advanced pancreatic cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Virtual Reality Images of the Home Are Useful for Patients With Hospital-Based Palliative Care: Prospective Observational Study With Analysis by Text Mining2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiographic duodenal invasion is associated with poor prognosis and early recurrence in patients with pancreatic ductal adenocarcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.2023

Hayami Shinya 速水晋也